{"title":"Sequence Diversity of FliC Protein from Enterobacteriaceae Family to Introducing a Promising Epitope-Delivery Platform","authors":"Sepideh Fereshteh, F. Badmasti","doi":"10.52547/vacres.7.2.85","DOIUrl":"https://doi.org/10.52547/vacres.7.2.85","url":null,"abstract":"","PeriodicalId":52727,"journal":{"name":"Vaccine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46382555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Justiz Vaillant, Ferrer Cosme, Fisher Smikle, O. Pérez
{"title":"Feeding Eggs from Hens Immunized with Specific KLH-Conjugated HIV Peptide Candidate Vaccines to Chicks Induces Specific Anti-HIV gp120 and gp41 Antibodies that Neutralize the Original HIV Antigens","authors":"Justiz Vaillant, Ferrer Cosme, Fisher Smikle, O. Pérez","doi":"10.52547/vacres.7.2.92","DOIUrl":"https://doi.org/10.52547/vacres.7.2.92","url":null,"abstract":"","PeriodicalId":52727,"journal":{"name":"Vaccine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47861440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Assessment of the 2017-2018 Post Measles Campaign Coverage Survey in the South-south Zone of Nigeria","authors":"O. Chime, Jennie Orji, C. Madu","doi":"10.52547/vacres.7.2.41","DOIUrl":"https://doi.org/10.52547/vacres.7.2.41","url":null,"abstract":"","PeriodicalId":52727,"journal":{"name":"Vaccine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47931418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vaccines are a major weapon to control the present COVID-19 pandemic. To achieve this goal, vaccines should confer a robust and long-lasting immunity against SARS-Cov-2. Breakthrough infections and waning immunity are currently observed in patients that recovered from COVID-19 as well as in the vaccinated people. Therefore, a highly effective vaccine is needed to control the present and future outbreaks. Exogenous Nacetyl- 5-methoxy-tryptamine or melatonin (MLT) is well known to potentiate an effective and equilibrated immune response in a variety of situation including viral and bacterial infections and vaccines against different microbial and cancer antigens. In regard to anti- SARS-Cov-2 vaccines, beside stimulating specific IgG production as well as specific CD4+ and CD8+ T cells, exogenous MLT might also enhance specific IgA and secretory IgA in the mucosae;hence, preventing the re-infection and/or asymptomatic transmission of the virus. Thus, a study is urgently proposed to evaluate the effects of MLT administration either before or after vaccination against SARS-Cov-2 to evaluate its effect on strength, quality and duration of the immunity. Las but not least, due to its powerful antioxidant and anti-inflammatory properties, MLT administration might minimize the occurrence of adverse events after the vaccination.
{"title":"The Well-Recognized Ability of Melatonin to Potentiate an Equilibrated Immune Response Calls for an Urgent Study about Its Use as an Adjuvant in Anti-SARS-Cov-2 Vaccines","authors":"G. Maestroni","doi":"10.52547/vacres.7.2.97","DOIUrl":"https://doi.org/10.52547/vacres.7.2.97","url":null,"abstract":"Vaccines are a major weapon to control the present COVID-19 pandemic. To achieve this goal, vaccines should confer a robust and long-lasting immunity against SARS-Cov-2. Breakthrough infections and waning immunity are currently observed in patients that recovered from COVID-19 as well as in the vaccinated people. Therefore, a highly effective vaccine is needed to control the present and future outbreaks. Exogenous Nacetyl- 5-methoxy-tryptamine or melatonin (MLT) is well known to potentiate an effective and equilibrated immune response in a variety of situation including viral and bacterial infections and vaccines against different microbial and cancer antigens. In regard to anti- SARS-Cov-2 vaccines, beside stimulating specific IgG production as well as specific CD4+ and CD8+ T cells, exogenous MLT might also enhance specific IgA and secretory IgA in the mucosae;hence, preventing the re-infection and/or asymptomatic transmission of the virus. Thus, a study is urgently proposed to evaluate the effects of MLT administration either before or after vaccination against SARS-Cov-2 to evaluate its effect on strength, quality and duration of the immunity. Las but not least, due to its powerful antioxidant and anti-inflammatory properties, MLT administration might minimize the occurrence of adverse events after the vaccination.","PeriodicalId":52727,"journal":{"name":"Vaccine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42066251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. A. Bahnamiry, H. Kaghazian, S. D. Mousavi-Nasab, M. Aghasadeghi, G. Bahramali
{"title":"Engineering and Development of VP4-VP7 Rotavirus Fusion Protein in Pichia pastoris","authors":"M. A. Bahnamiry, H. Kaghazian, S. D. Mousavi-Nasab, M. Aghasadeghi, G. Bahramali","doi":"10.52547/vacres.7.2.101","DOIUrl":"https://doi.org/10.52547/vacres.7.2.101","url":null,"abstract":"","PeriodicalId":52727,"journal":{"name":"Vaccine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42904585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ali Asadollahi-Amin, F. Ghiasvand, M. Hasibi, Simin Seyedpour, A. Barzegary, F. Ghadimi, Seyedahmad Seyedalinaghi, O. Dadras
We report a case series of nine patients with confirmed coronavirus disease 2019 (COVID-19) in Tehran, Iran. This paper also reports narrative information on the signs and symptoms of the patients and discusses the potential immunologic perspective of the disease, especially with respect to the cytokine storm.
{"title":"Patients with COVID‐19‐Associated Hematologic Abnormalities and the Potential Role of the Cytokine Storm: A Case Series Study","authors":"Ali Asadollahi-Amin, F. Ghiasvand, M. Hasibi, Simin Seyedpour, A. Barzegary, F. Ghadimi, Seyedahmad Seyedalinaghi, O. Dadras","doi":"10.52547/vacres.7.2.9","DOIUrl":"https://doi.org/10.52547/vacres.7.2.9","url":null,"abstract":"We report a case series of nine patients with confirmed coronavirus disease 2019 (COVID-19) in Tehran, Iran. This paper also reports narrative information on the signs and symptoms of the patients and discusses the potential immunologic perspective of the disease, especially with respect to the cytokine storm.","PeriodicalId":52727,"journal":{"name":"Vaccine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46616777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: There is a continued quest towards developing protective vaccines to halt and end the global pandemic of COVID-19 with the research predominantly driven by the developed world. Induction of herd immunity requires mass vaccination, and any avoidable delays would cause enormous health and economic losses. However, developing countries will experience extensive vaccine allocation challenges due to limited indigenous manufacturing and cold chain facilities.
{"title":"Ethical Considerations and Challenges Duringthe COVID-19 Vaccine Deployment: Experiences from an Indian Perspective","authors":"Basu Saurav","doi":"10.52547/vacres.7.2.56","DOIUrl":"https://doi.org/10.52547/vacres.7.2.56","url":null,"abstract":"Introduction: There is a continued quest towards developing protective vaccines to halt and end the global pandemic of COVID-19 with the research predominantly driven by the developed world. Induction of herd immunity requires mass vaccination, and any avoidable delays would cause enormous health and economic losses. However, developing countries will experience extensive vaccine allocation challenges due to limited indigenous manufacturing and cold chain facilities.","PeriodicalId":52727,"journal":{"name":"Vaccine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46984515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Milani, F. Rouhollah, Maryam Naseroleslami, A. Bolhassani
. After 48 hours, their transfection efficiency was evaluated using fluorescent microscopy and flow cytometry. Results: The pEGFP-nef , - hsp27, -hsp27-nef, -hsp70 and - hsp70 - nef constructs were successfully prepared in large scale and high purity. The results of cell transfection with each construct showed that the percentages of Nef-GFP, Hsp27-GFP, Hsp27-Nef-GFP, Hsp70-GFP, Hsp70-Nef-GFP, Hsp70-GFP + Nef-GFP and GFP expression were 53.1 0.2, 64.22 0.8, 57.1 0.7, 68.8 1.0, 61.7 0.7, 77.4 1.5 and 81.8 1.8, respectively. Conclusion: These data showed that the potency of Hsp70 was more than Hsp27 for increasing Nef-GFP expression in HEK-293T cells. Moreover, the delivery of pEGFP-nef along with pEGFP-hsp70 increased the rate of GFP population in the cells as compared to that in pEGFP-hsp70-nef. These constructs will be used for development of HIV-1 DNA vaccine in animal model in near Future.
{"title":"The Effects of Heat Shock Proteins on Delivery of HIV-1 Nef Antigen in Mammalian Cells","authors":"A. Milani, F. Rouhollah, Maryam Naseroleslami, A. Bolhassani","doi":"10.29252/vacres.7.1.54","DOIUrl":"https://doi.org/10.29252/vacres.7.1.54","url":null,"abstract":". After 48 hours, their transfection efficiency was evaluated using fluorescent microscopy and flow cytometry. Results: The pEGFP-nef , - hsp27, -hsp27-nef, -hsp70 and - hsp70 - nef constructs were successfully prepared in large scale and high purity. The results of cell transfection with each construct showed that the percentages of Nef-GFP, Hsp27-GFP, Hsp27-Nef-GFP, Hsp70-GFP, Hsp70-Nef-GFP, Hsp70-GFP + Nef-GFP and GFP expression were 53.1 0.2, 64.22 0.8, 57.1 0.7, 68.8 1.0, 61.7 0.7, 77.4 1.5 and 81.8 1.8, respectively. Conclusion: These data showed that the potency of Hsp70 was more than Hsp27 for increasing Nef-GFP expression in HEK-293T cells. Moreover, the delivery of pEGFP-nef along with pEGFP-hsp70 increased the rate of GFP population in the cells as compared to that in pEGFP-hsp70-nef. These constructs will be used for development of HIV-1 DNA vaccine in animal model in near Future.","PeriodicalId":52727,"journal":{"name":"Vaccine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48016767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arie Dwi Pratiwi, D. Endarti, T. Andayani, S. A. Kristina
Introduction: Parent’s knowledge on rotavirus diarrhea and vaccine might influence the decision to vaccinate a child. The purpose of this study was to examine knowledge level and to determine the factors that influence parents’ knowledge on rotavirus diarrhea and vaccine. Methods: The study applied an observational study design with a multi-center cross-sectional approach. The research instrument used a questionnaire to determine the sociodemographic variables and knowledge of respondents. Results: Data were collected from a survey of 500 parents in 5 provinces including Province of Central Kalimantan, Lampung, Central Sulawesi, West Java, and Yogyakarta in Indonesia using convenience sampling technique. Parents’ knowledge in this study was quite good with the average score of 78.2 ± 16.81. However, out of 500 respondents, only 158 (31.6%) parents knew that the rotavirus vaccine was not included in Indonesia's national health insurance program. There was a significant difference in the average of knowledge between the characteristics groups of age, education, monthly expenditure and experience of hearing diarrhea and rotavirus vaccine, vaccinating and source of disease information and vaccine (p <0.05). Conclusion: This study suggests the need of health promotion related to rotavirus diarrhea and vaccine in order to achieve equitable distribution of information and increase public knowledge to support future immunization programs. Citation: Pratiwi A D, Endarti D, Andayani T M, Kristina S A. Parent’s Knowledge on Rotavirus Diarrhea and Vaccine in Indonesia. vacres. 2020; 7 (1) :38-43. DOI: 10.29252/vacres.7.1.38
父母对轮状病毒腹泻和疫苗的了解可能会影响孩子接种疫苗的决定。本研究的目的是考察家长对轮状病毒腹泻和疫苗知识的了解程度，并确定影响家长对轮状病毒腹泻和疫苗知识的因素。方法:本研究采用多中心横断面观察性研究设计。研究工具使用问卷来确定社会人口变量和受访者的知识。结果:采用方便抽样法对印度尼西亚中加里曼丹省、楠榜省、中苏拉威西省、西爪哇省和日惹省5个省的500名家长进行了调查。家长对本次研究的认知程度较好，平均得分为78.2±16.81分。然而，在500名受访者中，只有158名(31.6%)家长知道轮状病毒疫苗不包括在印度尼西亚的国家健康保险计划中。年龄、受教育程度、月支出、耳鸣腹泻与轮状病毒疫苗接种经历、疫苗接种及疾病信息和疫苗来源等特征组的平均知识知晓程度差异有统计学意义(p <0.05)。结论:本研究提示有必要对轮状病毒腹泻和疫苗进行健康宣传，以实现信息的公平分配，增加公众知识，为未来的免疫规划提供支持。引文:Pratiwi A D, Endarti D, Andayani T M, Kristina S A.印度尼西亚家长对轮状病毒腹泻和疫苗的了解。vacres。2020;7(1):38-43。DOI: 10.29252 / vacres.7.1.38
{"title":"Parent’s Knowledge on Rotavirus Diarrhea and Vaccine in Indonesia","authors":"Arie Dwi Pratiwi, D. Endarti, T. Andayani, S. A. Kristina","doi":"10.29252/vacres.7.1.38","DOIUrl":"https://doi.org/10.29252/vacres.7.1.38","url":null,"abstract":"Introduction: Parent’s knowledge on rotavirus diarrhea and vaccine might influence the decision to vaccinate a child. The purpose of this study was to examine knowledge level and to determine the factors that influence parents’ knowledge on rotavirus diarrhea and vaccine. Methods: The study applied an observational study design with a multi-center cross-sectional approach. The research instrument used a questionnaire to determine the sociodemographic variables and knowledge of respondents. Results: Data were collected from a survey of 500 parents in 5 provinces including Province of Central Kalimantan, Lampung, Central Sulawesi, West Java, and Yogyakarta in Indonesia using convenience sampling technique. Parents’ knowledge in this study was quite good with the average score of 78.2 ± 16.81. However, out of 500 respondents, only 158 (31.6%) parents knew that the rotavirus vaccine was not included in Indonesia's national health insurance program. There was a significant difference in the average of knowledge between the characteristics groups of age, education, monthly expenditure and experience of hearing diarrhea and rotavirus vaccine, vaccinating and source of disease information and vaccine (p <0.05). Conclusion: This study suggests the need of health promotion related to rotavirus diarrhea and vaccine in order to achieve equitable distribution of information and increase public knowledge to support future immunization programs. Citation: Pratiwi A D, Endarti D, Andayani T M, Kristina S A. Parent’s Knowledge on Rotavirus Diarrhea and Vaccine in Indonesia. vacres. 2020; 7 (1) :38-43. DOI: 10.29252/vacres.7.1.38","PeriodicalId":52727,"journal":{"name":"Vaccine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44890095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Helminthiasis is a neglected public health challenge worldwide. The relevance of the important role of group 2 innate lymphoid cells (ILC2s) in the protection induced by type 2 immune responses against helminth infections has recently regained attention. The parasitic helminth infections remain as a major public health concern worldwide, particularly in tropical countries in several areas of Africa, Asia, and South America. It has been demonstrated in the experimental mouse models that ILC2s induce significant secretion of type 2 cytokines and develop protective immunity against parasitic helminths infections. However, the effects of helminth-induced immunity mediated by ILC2s have not yet been clearly defined. This review discusses the current status of the researches related to the evidence of ILC2s to improve the protective immunity in parasitic helminth infections and how these cells promote parasitic helminth expulsion. Citation: Méndez-Samperio P. The Importance of Group 2 Innate Lymphoid Cells to Improve the Protective Immunity in Parasitic Helminth Infections. vacres. 2020; 7 (1) :50-53. DOI: 10.29252/vacres.7.1.50
{"title":"The Importance of Group 2 Innate Lymphoid Cells to Improve the Protective Immunity in Parasitic Helminth Infections","authors":"P. Méndez-Samperio","doi":"10.29252/vacres.7.1.50","DOIUrl":"https://doi.org/10.29252/vacres.7.1.50","url":null,"abstract":"Helminthiasis is a neglected public health challenge worldwide. The relevance of the important role of group 2 innate lymphoid cells (ILC2s) in the protection induced by type 2 immune responses against helminth infections has recently regained attention. The parasitic helminth infections remain as a major public health concern worldwide, particularly in tropical countries in several areas of Africa, Asia, and South America. It has been demonstrated in the experimental mouse models that ILC2s induce significant secretion of type 2 cytokines and develop protective immunity against parasitic helminths infections. However, the effects of helminth-induced immunity mediated by ILC2s have not yet been clearly defined. This review discusses the current status of the researches related to the evidence of ILC2s to improve the protective immunity in parasitic helminth infections and how these cells promote parasitic helminth expulsion. Citation: Méndez-Samperio P. The Importance of Group 2 Innate Lymphoid Cells to Improve the Protective Immunity in Parasitic Helminth Infections. vacres. 2020; 7 (1) :50-53. DOI: 10.29252/vacres.7.1.50","PeriodicalId":52727,"journal":{"name":"Vaccine Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45154503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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