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Popliteal tendon impingement as a cause of pain following total knee arthroplasty: a systematic review. 腘肌腱撞击是全膝关节置换术后疼痛的原因:系统回顾。
IF 0.9 4区 医学 Q3 Medicine Pub Date : 2023-09-04 DOI: 10.1186/s42836-023-00201-7
Michael A Finsterwald, Victor Lu, Octavian Andronic, Gareth H Prosser, Piers J Yates, Christopher W Jones

Introduction: Popliteal tendon impingement (PTI) is an under-recognized cause of persistent pain following total knee arthroplasty (TKA). The purpose of the systematic review was to summarize and outline successful strategies in the diagnosis and management of PTI.

Methods: A systematic review following the PRISMA guidelines was performed for four databases: MEDLINE (Pubmed), Ovid EMBASE, Web of Science, and Cochrane Database. It was registered in the International Prospective Register for Systematic Reviews and Meta-analysis (PROSPERO) under the registration number: CRD42023398723. The risk of bias assessment was performed using the criteria of the methodological index for non-randomized studies (MINORS).

Results: A total of 8 studies were included. There were 2 retrospective case series and 6 case reports. The follow-up ranged from 6 to 30 months. Two studies described PTI as an intraoperative phenomenon during TKA with "snapping"; whilst 6 studies described indications and outcomes for arthroscopic tenotomy for PTI following TKA. In making the diagnosis, there was concurrence that the posterolateral pain should be focal and that dynamic ultrasonography and diagnostic injection play an important role. Two specific clinical tests have been described. There was no consistency regarding the need for imaging. There were no reports of instability following popliteal tendon tenotomy or other complications.

Conclusion: PTI should be suspected as a cause for persistent focal pain at the posterolateral knee following TKA. The diagnosis can be suspected on imaging and should be confirmed with dynamic ultrasonography and an ultrasound-guided diagnostic injection. An arthroscopic complete tenotomy of the tendon can reliably alleviate pain and relies on correct diagnosis. There is no evidence for clinically relevant negative biomechanical consequences following tenotomy.

Level of evidence: Systematic Review of Level IV and V studies.

引言:腘肌腱撞击(PTI)是全膝关节置换术(TKA)后持续疼痛的一个未被充分认识的原因。系统回顾的目的是总结和概述PTI诊断和管理的成功策略。方法:按照PRISMA指南对MEDLINE (Pubmed)、Ovid EMBASE、Web of Science和Cochrane Database四个数据库进行系统评价。该药物已在国际前瞻性系统评价和荟萃分析注册库(PROSPERO)注册,注册号为CRD42023398723。偏倚风险评估采用非随机研究(未成年人)的方法学指标标准。结果:共纳入8项研究。有2个回顾性病例系列和6个病例报告。随访6 ~ 30个月。两项研究将PTI描述为TKA术中出现的“咔嗒”现象;而6项研究描述了关节镜下肌腱切断术治疗TKA后PTI的适应症和结果。在诊断时,一致认为后外侧疼痛应是局灶性的,动态超声检查和诊断注射发挥重要作用。描述了两种具体的临床试验。关于成像的需要没有一致性。没有腘肌腱肌腱切开术后不稳定或其他并发症的报道。结论:应怀疑PTI是TKA后膝关节后外侧持续局灶性疼痛的原因。在影像学上可以怀疑诊断,应通过动态超声检查和超声引导下的诊断注射来确诊。关节镜下完全肌腱切断术可以可靠地减轻疼痛,并依赖于正确的诊断。肌腱切断术后没有临床相关的负生物力学后果的证据。证据水平:IV级和V级研究的系统评价。
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引用次数: 0
Standard versus short stem cemented Exeter® when used for primary total hip arthroplasty: a survivorship analysis. 标准与短柄骨水泥Exeter®用于初次全髋关节置换术:生存分析
IF 0.9 4区 医学 Q3 Medicine Pub Date : 2023-09-03 DOI: 10.1186/s42836-023-00200-8
Nick D Clement, Liam Z Yapp, Leo D Baxendale-Smith, Deborah MacDonald, Colin R Howie, Paul Gaston

Aims: The aims were to compare the survival of the cemented standard (150 mm) with the short (DDH [35.5 mm offset or less], number 1 short stem [125 mm options of 37.5 mm, 44 mm, 50 mm offset] and revision [44/00/125]) Exeter® V40 femoral stems when used for primary total hip arthroplasty (THA).

Methods: Patients were retrospectively identified from an arthroplasty database. A total of 664 short stem Exeter® variants were identified, of which 229 were DDH stems, 208 number 1 stems and 227 revision stems were implanted between 2011 and 2020. A control group of 698 standard Exeter® stems used for THA was set up, and were followed up for a minimum of 10 years follow-up (implanted 2011). All-cause survival was assessed for THA and for the stem only. Adjusted analysis was undertaken for age, sex and ASA grade.

Results: The median survival time for the short stems varied according to design: DDH had a survival time of 6.7 years, number 1 stems 4.1 years, and revision stems 7.2 years. Subjects in the short stem group (n = 664) were significantly younger (mean difference 5.1, P < 0.001) and were more likely to be female (odds ratio 1.89, 95% CI 1.50 to 2.39, P < 0.001), compared to the standard group. There were no differences in THA (P = 0.26) or stem (P = 0.35) survival at 5 years (adjusted THA: 98.3% vs. 97.2%; stem 98.7% vs. 97.8%) or 10 years (adjusted THA 97.0% vs. 96.0 %; stem 96.7% vs. 96.2%) between standard and short stem groups, respectively. At 5 years no differences were found in THA (DDH: 96.7%, number 1 97.5%, revision 97.3%, standard 98.6%) or stem (DDH: 97.6%, number 1 99.0%, revision 97.3%, standard 98.2%) survival between/among the different short stems or when compared to the standard group.

Conclusion: The Exeter® short stems offer equivocal survival when compared to the standard stem at 5- to 10-year follow-up, which does not seem to be influenced by the short stem design.

目的:目的是比较用于初次全髋关节置换术(THA)时,标准骨水泥(150 mm)与短(DDH [35.5 mm偏移或更少],1号短柄[37.5 mm, 44 mm, 50 mm偏移的125 mm选项]和改进型[44/0 /125])Exeter®V40股骨柄的生存率。方法:回顾性地从关节成形术数据库中确定患者。共鉴定出664个短茎Exeter®变体,其中在2011年至2020年期间植入了229个DDH茎,208个1号茎和227个修复茎。建立698个用于THA的标准Exeter®假体作为对照组,随访至少10年(植入2011年)。全因生存评估为THA和仅为干。对年龄、性别和ASA分级进行调整分析。结果:短茎的中位生存时间因设计而异:DDH的生存时间为6.7年,1号茎4.1年,翻修茎7.2年。与标准组相比,短茎组(n = 664)的受试者明显更年轻(平均差5.1,P < 0.001),并且更可能是女性(优势比1.89,95% CI 1.50至2.39,P < 0.001)。5年THA (P = 0.26)或stem (P = 0.35)生存率无差异(调整THA: 98.3% vs 97.2%;干98.7%对97.8%)或10年(调整后的THA 97.0%对96.0%;标准组和短茎组的差异分别为96.7%和96.2%。5年时,不同短茎之间或与标准组相比,THA (DDH: 96.7%,编号1 97.5%,修订97.3%,标准98.6%)或茎(DDH: 97.6%,编号1 99.0%,修订97.3%,标准98.2%)的生存率无差异。结论:在5- 10年的随访中,与标准支架相比,Exeter®短支架的生存率不确定,短支架的设计似乎不受其影响。
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引用次数: 0
Joint aspiration for diagnosis of chronic periprosthetic joint infection: when, how, and what tests? 关节抽吸诊断慢性假体周围关节感染:何时、如何以及哪些检查?
IF 0.9 4区 医学 Q3 Medicine Pub Date : 2023-09-02 DOI: 10.1186/s42836-023-00199-y
Nicole Durig Quinlan, Jason M Jennings

Diagnosing chronic periprosthetic joint infection (PJI) requires clinical suspicion in combination with both serological and synovial fluid tests, the results of which are generally applied to validated scoring systems or consensus definitions for PJI. As no single "gold standard" test exists, the diagnosis becomes challenging, especially in the setting of negative cultures or equivocal test results. This review aims to address the workup of chronic PJI and considerations for clinical evaluation to guide treatment. Following aspiration of the joint in question, a multitude of tests has been developed in an attempt to assist with diagnosis, including cell synovial white blood cell count, gram stain, cultures, leukocyte esterase, alpha-defensin, synovial C-reactive protein, multiplex polymerase chain reaction, next-generation sequencing, and interleukins. Each test has advantages and disadvantages and should be used in conjunction with the overall clinical picture to guide further clinical evaluation and treatment in this complex patient population.

诊断慢性假体周围关节感染(PJI)需要结合血清学和滑液检查进行临床怀疑,其结果通常应用于经过验证的评分系统或PJI的共识定义。由于不存在单一的“金标准”测试,诊断变得具有挑战性,特别是在阴性培养或模棱两可的测试结果的情况下。本综述旨在探讨慢性PJI的检查和临床评估的注意事项,以指导治疗。在有问题的关节抽吸后,已经开发了许多测试来帮助诊断,包括细胞滑膜白细胞计数、革兰氏染色、培养、白细胞酯酶、α -防御素、滑膜c反应蛋白、多重聚合酶链反应、新一代测序和白细胞介素。每种测试都有优点和缺点,应结合整体临床情况使用,以指导对这一复杂患者群体的进一步临床评估和治疗。
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引用次数: 0
Clinical outcomes of DAA and related techniques in hip arthroplasty. DAA及相关技术在髋关节置换术中的临床效果。
IF 0.9 4区 医学 Q3 Medicine Pub Date : 2023-09-01 DOI: 10.1186/s42836-023-00198-z
Adam Driesman, Charlie C Yang

Total hip arthroplasty (THA) has been one of the most successful surgical interventions in recent memory and is nicknamed by some the "Surgery of the Century". Over the past decade, there has been a drastic change in THA management with the rise of the direct anterior approach both globally and in the USA market. While many would remark that this has been driven by false marketing, it is clear that the direct anterior approach can be an effective and safe way to perform a THA.It is the goal of this review to highlight evidence of its outcomes and clinical advantages, in particular, how it can decrease dislocation, even in high-risk individuals, and result in faster recovery in the early postoperative period with decreased muscular inflammation. We will also highlight its major disadvantages, including but not limited to increased wound complications and risk for periprosthetic fracture. Hopefully, this review will provide up-to-date information on the current state of the direct anterior approach and provide recommendations on patients that would be optimal candidates for this technique.

全髋关节置换术(THA)是近年来最成功的手术干预之一,被一些人戏称为“世纪手术”。在过去的十年中,随着全球和美国市场直接前路入路的兴起,THA的管理发生了巨大的变化。虽然许多人会说这是由虚假营销驱动的,但很明显,直接前路入路是一种有效且安全的THA手术方式。本综述的目的是强调其结果和临床优势的证据,特别是它如何减少脱位,甚至在高危人群中,并在术后早期更快地恢复,减少肌肉炎症。我们还将强调其主要缺点,包括但不限于增加伤口并发症和假体周围骨折的风险。希望这篇综述能够提供关于直接前路入路现状的最新信息,并为该技术的最佳候选患者提供建议。
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引用次数: 0
Factors that impact the patellofemoral contact stress in the TKA: a review. 影响膝关节置换术中髌股接触应力的因素综述。
IF 0.9 4区 医学 Q3 Medicine Pub Date : 2023-08-05 DOI: 10.1186/s42836-023-00197-0
Zhenguo Yu, Hong Cai, Zhongjun Liu

Abnormal retro patellar stress is believed to contribute to patellofemoral complications after total knee arthroplasty (TKA), but the causal link between TKA and patellofemoral contact stress remains unclear. By reviewing the relevant studies, we found that both TKA implantation and additional patellar resurfacing increase retro patellar pressure. The rotation and size of the femoral component, thickness and position of the patellar component, installation of the tibial component, prosthesis design and soft tissue balance further influence patellofemoral stress. Specific measures can be applied to reduce stress, including the installation of the femoral prosthesis with an appropriate external rotation angle, placing the tibial component at a more posterior position and the patellar button at a more medial position, avoiding over-sized femoral and patellar components, selecting posterior-stabilized design rather than cruciate-retaining design, using gender-specific prosthesis or mobile-bearing TKA system, and releasing the lateral retinaculum or performing partial lateral facetectomy. Despite these measures, the principle of individualization should be followed to optimize the patellofemoral biomechanics.

异常的髌骨应力被认为是全膝关节置换术(TKA)后髌骨股并发症的原因之一,但TKA与髌骨股接触应力之间的因果关系尚不清楚。通过回顾相关研究,我们发现TKA植入和额外的髌骨表面置换都增加了髌骨逆行压力。股骨假体的旋转和大小、髌骨假体的厚度和位置、胫骨假体的安装、假体设计和软组织平衡进一步影响髌股应力。可以采取具体措施来减轻应力,包括以适当的外旋角度安装股骨假体,将胫骨假体放置在更后侧的位置,将髌骨钮扣放置在更内侧的位置,避免过大的股骨和髌骨假体,选择后稳定设计而不是保留十字架的设计,使用特定性别的假体或移动轴承TKA系统。释放外侧支持带或进行部分外侧面切除术。尽管采取了这些措施,但应遵循个体化原则来优化髌股生物力学。
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引用次数: 0
The role of telemedicine in joint replacement surgery? An updated review. 远程医疗在关节置换手术中的作用?最新的评论。
IF 0.9 4区 医学 Q3 Medicine Pub Date : 2023-08-04 DOI: 10.1186/s42836-023-00196-1
Ka Yau Li, Ping Keung Chan, Shun Shing Yeung, Amy Cheung, Wai Kwan Vincent Chan, Michelle Hilda Luk, Man Hong Cheung, Henry Fu, Kwong Yuen Chiu

The usage of telemedicine and telehealth services has grown tremendously and has become increasingly relevant and essential. Technological advancements in current telehealth services have supported its use as a viable alternative tool to conduct visits for consultations, follow-up, and rehabilitation in total joint arthroplasty. Such technology has been widely implemented, particularly during the coronavirus 2019 (COVID-19) pandemic, to deliver postoperative rehabilitation among patients receiving total joint arthroplasty (TJA), further demonstrating its feasibility with a lower cost yet comparable clinical outcomes when compared with traditional care. There remains ample potential to utilize telemedicine for prehabilitation to optimize the preoperative status and postoperative outcomes of patients with osteoarthritis. In this review, various implementations of telemedicine within total joint arthroplasty and future application of telemedicine to deliver tele-prehabilitation in TJA are discussed.

远程医疗和远程保健服务的使用已大大增加,并变得越来越相关和必不可少。目前远程保健服务的技术进步支持将其作为一种可行的替代工具,在全关节置换术中进行会诊、随访和康复。该技术已被广泛应用,特别是在2019冠状病毒(COVID-19)大流行期间,为接受全关节置换术(TJA)的患者提供术后康复服务,进一步证明了其可行性,与传统护理相比,其成本更低,但临床结果相当。利用远程医疗进行预康复以优化骨关节炎患者的术前状态和术后结果仍有很大的潜力。本文综述了远程医疗在全关节置换术中的各种应用,并讨论了远程医疗在全关节置换术中远程康复的未来应用。
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引用次数: 1
Mapping the course to recovery: a prospective study on the anatomic distribution of early postoperative pain after total knee arthroplasty. 绘制康复过程:全膝关节置换术后早期疼痛解剖分布的前瞻性研究。
IF 0.9 4区 医学 Q3 Medicine Pub Date : 2023-08-03 DOI: 10.1186/s42836-023-00194-3
Kevin L Mekkawy, Bo Zhang, Alyssa Wenzel, Andrew B Harris, Harpal S Khanuja, Robert S Sterling, Vishal Hegde, Julius K Oni

Introduction: Early postoperative pain following total knee arthroplasty significantly impacts outcomes and patient satisfaction. However, the characteristics and sources of early pain after total knee arthroplasty remain unclear. Therefore, the purpose of this study was to determine the anatomic distribution and course of postoperative pain in the acute and subacute period following total knee arthroplasty.

Methods: A prospective observational study of primary, elective unilateral total knee arthroplasty cases was conducted at our academic tertiary care medical center from January 2021 to September 2021. Preoperative variables were extracted from institutional electronic medical records. Postoperatively, patients utilized a knee pain map to identify the two locations with the most significant pain and rated it using the visual analog scale (VAS). The data were collected on day 0, at 2 weeks, 2 months, and 6 months after operation.

Results: This study included 112 patients, with 6% of patients having no pain at postoperative day 0, 22% at 2 weeks, 46% at 2 months, and 86% at 6 months after operation. In those who reported pain, the VAS score (mean ± standard deviation) was 5.8 ± 2.4 on postoperative day 0 and decreased at each follow-up time point (5.4 ± 2.3 at 2 weeks, 3.9 ± 2.2 at 2 months, and 3.8 ± 2.7 at 6 months). The majority of patients were able to identify distinct loci of pain. The most common early pain loci were patellae, thigh, and medial joint line, and this distribution dissipated by 6 months.

Conclusion: At 2 postoperative weeks, pain was primarily at the medial joint, and at 6 months postoperatively, pain was more likely to be at the lateral joint. No relationship was found between pain at six months and pain scores or location at postoperative day 0 or 2 weeks. Understanding the distribution and progression of knee pain following total knee arthroplasty may benefit patient education and targeted interventions.

Level of evidence: Level II, prospective observational study.

引言:全膝关节置换术后早期疼痛显著影响结果和患者满意度。然而,全膝关节置换术后早期疼痛的特征和来源尚不清楚。因此,本研究的目的是确定全膝关节置换术后急性和亚急性期疼痛的解剖分布和过程。方法:于2021年1月至2021年9月在我们的学术三级医疗中心对原发性、选择性单侧全膝关节置换术病例进行前瞻性观察研究。术前变量从机构电子病历中提取。术后,患者使用膝关节疼痛图来确定疼痛最明显的两个位置,并使用视觉模拟量表(VAS)进行评分。分别于术后第0天、第2周、第2个月和第6个月采集数据。结果:本研究纳入112例患者,术后0天无疼痛的患者占6%,术后2周无疼痛的患者占22%,术后2个月无疼痛的患者占46%,术后6个月无疼痛的患者占86%。在报告疼痛的患者中,VAS评分(平均值±标准差)在术后第0天为5.8±2.4,在每个随访时间点下降(2周时为5.4±2.3,2个月时为3.9±2.2,6个月时为3.8±2.7)。大多数患者能够识别不同的疼痛部位。最常见的早期疼痛部位是髌骨、大腿和内侧关节线,这种分布在6个月后消失。结论:术后2周时,疼痛主要发生在内侧关节,6个月时,疼痛更多发生在外侧关节。6个月时的疼痛与术后第0天或第2周的疼痛评分或位置没有关系。了解全膝关节置换术后膝关节疼痛的分布和进展可能有利于患者教育和有针对性的干预。证据等级:II级,前瞻性观察性研究。
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引用次数: 0
Arithmetic hip knee angle measurement on long leg radiograph versus computed tomography-inter-observer and intra-observer reliability. 长腿X光片与计算机断层扫描的髋膝关节角算术测量--观察者之间和观察者内部的可靠性。
IF 2.3 4区 医学 Q2 ORTHOPEDICS Pub Date : 2023-08-02 DOI: 10.1186/s42836-023-00193-4
Tom Jan Gieroba, Sofia Marasco, Sina Babazadeh, Claudia Di Bella, Dirk van Bavel

Background: Pre-operative alignment is important for knee procedures including total knee arthroplasty (TKA), especially when considering alternative alignments. The arithmetic Hip Knee Angle (aHKA) is a measure of coronal alignment calculated using the medial proximal tibial (MPTA) and lateral distal femoral angles (LDFA). Traditionally, aHKA is measured on long leg radiographs (LLR). This study assesses the reproducibility of aHKA measurement on LLR and robotic-assisted TKA planning CT.

Methods: Sixty-eight TKA patients with pre-operative LLR and planning CTs were included. Three observers measured the LDFA, MPTA and aHKA three times on each modality and intra-observer and inter-observer reliability was calculated. Statistical analysis was undertaken with Pearson's r and the Bland-Altman test.

Results: Mean intra-observer coefficient of repeatability (COR) for LLR vs. CT: MPTA 3.50° vs. 1.73°, LDFA 2.93° vs. 2.00° and aHKA 2.88° vs. 2.57° for CT. Inter-observer COR for LLR vs. CT: MPTA 2.74° vs. 1.28°, LDFA 2.31° vs. 1.92°, aHKA 3.56° vs. 2.00°. Mean intra-observer Pearson's r for MPTA was 0.93 for LLR and 0.94 for CT, LDFA 0.90 for LLR and 0.91 for CT and aHKA 0.92 for LLR and 0.94 for CT. Inter-observer Pearson's r for LLR compared to CT: MPTA 0.93 vs. 0.97, LDFA 0.91 vs. 0.90, aHKA 0.91 and 0.95.

Conclusion: When compared to LLR, CT measurements of MPTA, LDFA and aHKA are more reproducible and have a good correlation with LLR measurement. CT overcomes difficulties with positioning, rotation, habitus and contractures when assessing coronal plane alignment and may obviate the need for LLRs.

背景:术前对位对于包括全膝关节置换术(TKA)在内的膝关节手术非常重要,尤其是在考虑其他对位方式时。膝髋关节角度(aHKA)是通过胫骨内侧近端角(MPTA)和股骨外侧远端角(LDFA)计算得出的冠状位对齐度。传统上,aHKA 是通过长腿X光片(LLR)测量的。本研究评估了在 LLR 和机器人辅助 TKA 规划 CT 上测量 aHKA 的可重复性:方法:研究纳入了 68 名接受术前 LLR 和计划 CT 检查的 TKA 患者。三名观察者在每种模式下测量 LDFA、MPTA 和 aHKA 三次,并计算观察者内和观察者间的可靠性。统计分析采用 Pearson's r 和 Bland-Altman 检验:LLR与CT的平均观察者内重复性系数(COR):MPTA为3.50°,CT为1.73°;LDFA为2.93°,CT为2.00°;aHKA为2.88°,CT为2.57°。LLR 与 CT 的观察者间 COR:MPTA 2.74° vs. 1.28°,LDFA 2.31° vs. 1.92°,aHKA 3.56° vs. 2.00°。MPTA LLR 和 CT 的平均观测者内 Pearson's r 分别为 0.93 和 0.94,LDFA LLR 和 CT 的平均观测者内 Pearson's r 分别为 0.90 和 0.91,aHKA LLR 和 CT 的平均观测者内 Pearson's r 分别为 0.92 和 0.94。与 CT 相比,LLR 的观察者间皮尔逊 r:MPTA 为 0.93 vs. 0.97,LDFA 为 0.91 vs. 0.90,aHKA 为 0.91 和 0.95:与 LLR 相比,CT 对 MPTA、LDFA 和 aHKA 的测量具有更高的可重复性,并且与 LLR 测量具有良好的相关性。在评估冠状面排列时,CT 克服了定位、旋转、习性和挛缩方面的困难,因此可能不需要 LLR。
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引用次数: 0
Current relevance of biomarkers in diagnosis of periprosthetic joint infection: an update. 生物标志物在假体周围关节感染诊断中的当前相关性:最新进展。
IF 0.9 4区 医学 Q3 Medicine Pub Date : 2023-08-01 DOI: 10.1186/s42836-023-00192-5
Saksham Tripathi, Saad Tarabichi, Javad Parvizi, Ashok Rajgopal

With a significant rise in the number of arthroplasty procedures performed worldwide, the increasing revision burden posed by periprosthetic joint infection (PJI) is a matter of growing concern. In spite of various attempts to diagnose PJI, there are no defined tests that can be called a gold standard. Given the importance of early diagnosis in PJI, newer tests and biomarkers have been introduced to improve cumulative diagnostic accuracy. Novel biomarkers like calprotectin, lipocalcin, monocyte-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and platelet-to-mean platelet volume ratio have demonstrated a potential as diagnostic biomarkers for PJI. This article discusses the relevance of available and newly described diagnostic biomarkers to provide a perspective on the practical applicability in current medical practice, as well as highlights some recent advances in biomarkers for the diagnosis of PJI.

随着世界范围内关节置换术数量的显著增加,假体周围关节感染(PJI)带来的翻修负担日益增加,这是一个日益受到关注的问题。尽管有各种各样的尝试来诊断PJI,但没有定义的测试可以被称为金标准。鉴于PJI早期诊断的重要性,新的检测和生物标志物已被引入以提高累积诊断的准确性。新的生物标志物,如钙保护蛋白、脂钙素、单核细胞与淋巴细胞比率、中性粒细胞与淋巴细胞比率、血小板与淋巴细胞比率和血小板与平均血小板体积比,已被证明有潜力作为PJI的诊断生物标志物。本文讨论了可用的和新描述的诊断性生物标志物的相关性,提供了在当前医学实践中的实际适用性的观点,并重点介绍了生物标志物在PJI诊断中的一些最新进展。
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引用次数: 0
Outcomes of total hip and knee arthroplasty in special populations: a synopsis and critical appraisal of systematic reviews. 特殊人群全髋关节和膝关节置换术的结果:系统综述的摘要和关键评价。
IF 0.9 4区 医学 Q3 Medicine Pub Date : 2023-07-06 DOI: 10.1186/s42836-023-00190-7
Dimitris Challoumas, David Munn, Henrietta Stockdale, Nigel Ng, Michael McCormick, Tareq Altell, Shaheer Joiya, James Horton, Bryn Jones

Introduction: This study aimed to present and critically appraise the best available evidence investigating associations between some pre-defined patient-related characteristics and perioperative complications or other outcomes in THA and TKA.

Methods: Electronic databases were searched (Medline, EMBASE, Scopus, CENTRAL) for systematic reviews assessing the following pre-defined patient-related characteristics as possible risk factors for worse peri-operative outcomes in THA and TKA: smoking, alcohol excess, rheumatoid arthritis, human immunodeficiency virus infection, hepatitis C virus infection, mental health conditions, and solid organ transplantation. Our primary outcome was periprosthetic joint infection. Results were analysed separately for THA, TKA and THA/TKA (mixed data).

Results: Based on at least two systematic reviews being in agreement, the following patient-related characteristics were associated with increased incidence of complications as follows: a) Smoking for all-cause revision in THA, for periprosthetic joint infection in TKA and THA/TKA; b) alcohol excess for periprosthetic joint infection in THA/TKA; c) human immunodeficiency virus for periprosthetic joint infection in THA/TKA; d) hepatitis C virus for overall complications, periprosthetic joint infection and all-cause revision in THA and THA/TKA, and for overall complications in TKA. Our study found conflicting evidence for a) smoking as a risk factor for periprosthetic joint infection and aseptic loosening in THA; b) human immunodeficiency virus as a risk factor for all-cause revision for THA/TKA; c) hepatitis C virus as a risk factor for periprosthetic joint infection and all-cause revision in TKA. No certainty of evidence was assigned to these results as this was not assessed by the authors of the majority of the included systematic reviews.

Conclusion: We found that smoking, excess alcohol consumption, RA, and infection with HIV and HCV were associated with a higher incidence of periprosthetic joint infection in one or both of THA and TKA or mixed THA/TKA data. All our results should be interpreted and communicated to patients with caution as the quality of the included systematic reviews was generally poor.

简介:本研究旨在提出并批判性地评估现有的最佳证据,以调查THA和TKA中一些预先定义的患者相关特征与围手术期并发症或其他结局之间的关系。方法:检索电子数据库(Medline, EMBASE, Scopus, CENTRAL)进行系统评价,评估以下预先定义的患者相关特征作为THA和TKA围手术期预后较差的可能危险因素:吸烟、过量饮酒、类风湿关节炎、人类免疫缺陷病毒感染、丙型肝炎病毒感染、精神健康状况和实体器官移植。我们的主要结局是假体周围关节感染。分别对THA、TKA和THA/TKA(混合数据)的结果进行分析。结果:基于至少两项一致的系统评价,以下患者相关特征与并发症发生率增加相关:a)全因翻修THA中吸烟,全因翻修TKA和THA/TKA中假体周围关节感染;b) THA/TKA患者假体周围关节感染的酒精过量;c) THA/TKA患者假体周围关节感染的人类免疫缺陷病毒;d)丙型肝炎病毒导致THA和THA/TKA的总体并发症、假体周围关节感染和全因翻修,以及TKA的总体并发症。我们的研究发现了相互矛盾的证据:a)吸烟是THA患者假体周围关节感染和无菌性松动的危险因素;b)人类免疫缺陷病毒作为全因修订THA/TKA的危险因素;c)丙型肝炎病毒是TKA患者假体周围关节感染和全因修正的危险因素。这些结果没有确定的证据,因为大多数纳入的系统评价的作者没有对这些结果进行评估。结论:我们发现吸烟、过量饮酒、类风湿关节炎、HIV和HCV感染与THA和TKA中的一种或两种或混合THA/TKA数据中假体周围关节感染的发生率较高相关。我们所有的结果都应该谨慎地解释和告知患者,因为纳入的系统评价的质量通常很差。
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引用次数: 1
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Arthroplasty
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