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COVID-19 infection in pregnant women with preeclampsia and HELLP syndrome, with possible vertical transmission to the fetus: a case report 患有子痫前期和HELLP综合征的孕妇感染COVID-19,可能垂直传播给胎儿:1例报告
Pub Date : 2022-09-15 DOI: 10.30595/medisains.v20i2.14036
Sulistiari Retnowati, Alfaina Wahyuni, Nabila A Pramono
Background: During pregnancy, a woman's immune cells undergo cellular and functional alterations, rendering them more vulnerable to illness. Preeclampsia and HELLP syndromes are pregnancy problems and one of Indonesia's leading causes of maternal mortality; COVID-19 infection would exacerbate the situation. The evidence for COVID-19 vertical transmission is not well established, and the report on the incidence of vertical transmission, especially in Indonesia, is still limited.Case presentation: We discuss the case of a 26-year-old, 36 weeks of gestation, with preeclampsia and HELLP syndrome, who was infected with COVID-19 and got severe pneumonia and ARDS. The infant was born by cesarean section, and there was no contact between the infant and mother following delivery. Based on the results of the PCR examination, the baby was also confirmed to have COVID-19 without any symptoms.Conclusion: Vertical transmission during pregnancy is possible in women with a severe type of COVID-19 with preeclampsia and HELLP syndrome.
背景:在怀孕期间,妇女的免疫细胞经历细胞和功能的改变,使她们更容易生病。子痫前期和HELLP综合征是妊娠问题,也是印度尼西亚孕产妇死亡的主要原因之一;COVID-19感染将加剧这种情况。COVID-19垂直传播的证据尚未得到充分确立,关于垂直传播发生率的报告,特别是在印度尼西亚,仍然有限。病例介绍:我们讨论了一例26岁,妊娠36周,患有先兆子痫和HELLP综合征,感染COVID-19并出现严重肺炎和ARDS的病例。该婴儿是通过剖宫产出生的,分娩后婴儿和母亲之间没有接触。根据聚合酶链反应(PCR)检查结果,该婴儿也被确诊为新冠肺炎,但没有任何症状。结论:重症COVID-19合并子痫前期和HELLP综合征的妇女在妊娠期间可能存在垂直传播。
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引用次数: 0
Depression and prevention during the COVID-19 pandemic COVID-19大流行期间的抑郁与预防
Pub Date : 2022-09-15 DOI: 10.30595/medisains.v20i2.15066
Juli Widiyanto, Silvia Elki Putri
The impact of the COVID-19 pandemic affects all aspects, namely aspects of health, economy, education, and social life. Depression is a problem that everyone is at risk of experiencing during the COVID-19 pandemic. The condition of depression dramatically affects quality and productivity, primarily if it occurs at a productive age. Depression requires primary, secondary, and tertiary prevention at individual, family, group, and community levels.
COVID-19大流行的影响涉及卫生、经济、教育和社会生活等各个方面。在2019冠状病毒病大流行期间,抑郁症是每个人都有可能遇到的问题。抑郁症会极大地影响工作质量和工作效率,尤其是当它发生在一个有生产力的年龄时。抑郁症需要在个人、家庭、团体和社区层面进行一级、二级和三级预防。
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引用次数: 0
Drink combination made from Fenugreek seeds and Phoenix dac-tylifera to increase prolactin hormone levels in postpartum mothers and its impact on baby weight 由胡芦巴籽和凤凰花混合制成的饮料,可以提高产后母亲的催乳激素水平,并对婴儿体重产生影响
Pub Date : 2022-09-15 DOI: 10.30595/medisains.v20i2.14240
S. Halimah, Krisdiana Wijayanti, Taadi Taadi
Background: Breast milk is the best leading food for the growth and development of the baby; however, the production of breast milk produced by breastfeeding mothers is still lacking and impacts the baby's weight. One of the efforts is consuming a combination drink of Fenugreek seeds and Phoenix dactylifera containing galactagogue, which has never been done in this study before, to see an increase in breast milk production from indicators of prolactin hormone levels and its impact on baby weight.Purpose: Knowing the effect of giving drinks a combination of Fenugreek seeds and Phoenix dactylifera on the hormone prolactin and its impact on baby weight.Methods: This is an experimental study with a combination design, pretest-posttest, and posttest-only design. Respondents totaled 32 breastfeeding mothers, 16 were given drinks combination of Fenugreek seeds and Phoenix dactylifera, and 16 were given Phoenix dactylifera drinks. The intervention was given for 14 days, and the Mann-Whitney test analyzed prolactin hormone and baby weight using the Independent T-test.Results: Mean levels of the hormone prolactin in the intervention group were higher (279.52 ng/ml) than in the control group (263.31 ng/ml) with p>0.05. The average increase in body weight of infants of the intervention group (606.25 g) was higher than the control group (381.25 g) with a p<0.05.Conclusion: A drink combination made from Fenugreek seeds and Phoenix dactylifera can increase hormone prolactin. However, it is not statistically meaningful, and mothers who consume drinks have babies weighing higher than mothers who only give Phoenix dactylifera drinks.
背景:母乳是婴儿生长发育的最佳主导食物;然而,母乳喂养的母亲产生的母乳仍然缺乏,并影响婴儿的体重。其中一项努力是饮用含有催乳剂的胡芦巴籽和凤尾草的组合饮料,这在以前的研究中从未做过,通过催乳激素水平的指标及其对婴儿体重的影响来观察母乳产量的增加。目的:了解胡芦巴籽和凤凰花混合饮料对催乳素激素的影响及其对婴儿体重的影响。方法:采用组合设计、前测-后测设计和后测设计。调查对象共32名母乳喂养的母亲,其中16名给予葫芦巴籽和凤尾草混合饮料,16名给予凤尾草饮料。干预为期14天,曼-惠特尼检验使用独立t检验分析催乳素激素和婴儿体重。结果:干预组平均催乳素水平(279.52 ng/ml)高于对照组(263.31 ng/ml),差异有统计学意义(p < 0.05)。干预组婴儿体重平均增加606.25 g,高于对照组381.25 g,差异有p<0.05。结论:胡芦巴籽与凤凰花复方饮料可提高催乳素水平。然而,这在统计上没有意义,饮用饮料的母亲比只喝凤尾草饮料的母亲的婴儿体重更高。
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引用次数: 0
Progressive muscle relaxation application (PURE App) for dysmenorrhea 渐进式肌肉放松应用(PURE App)治疗痛经
Pub Date : 2022-09-15 DOI: 10.30595/medisains.v20i2.14351
Tharra Widadari Aldinda, S. Sumarni, D. K. Mulyantoro, M. Azam, S. Sudiyono
Background: The prevalence of primary dysmenorrhea in Indonesia is 54.89%. Progressive Muscle Relaxation (PMR) exercises have proven to decrease the symptoms of dysmenorrhea. Nowadays, the android application can be widely accessed anywhere and anytime, thus saving time and costs. There has never been a study that applies PMR, especially android-based dysmenorrhoea.Objective: The current study aimed to develop the PURE App, a PMR exercise android-based application, and to test the effectiveness of reducing the menstrual pain score of adolescents with primary dysmenorrhea.Method: This study conducted Research and Development (R&D), which consists of 4 stages, namely information collection, application design, expert validation and revision, and trial.Result: The PURE App has five features, ranging from pain screening to exercise. The trial results showed that the PURE App application effectively reduced menstrual pain in adolescents with dysmenorrhea. The treatment decreased pain score from 4.48±0.71 to 1.98±1.49 in the treatment group (p<0.001). The treatment group's post-measurement pain score was also significantly different compared to the control group, 1.98±1.49 and 4.90±1.10, respectively.Conclusion: The PURE App benefits teenagers, especially those with primary dysmenorrhea. This application will make it easier for teenagers to overcome pain because the exercises on the application can be accessed anytime and anywhere.
背景:印度尼西亚原发性痛经患病率为54.89%。渐进式肌肉放松(PMR)练习已被证明可以减少痛经的症状。如今,android应用程序可以随时随地广泛访问,从而节省了时间和成本。从未有研究应用PMR,特别是基于android的痛经。目的:本研究旨在开发基于android的PMR运动应用程序PURE App,测试其对青少年原发性痛经患者月经疼痛评分的降低效果。方法:本研究进行研究与开发(R&D),共分为信息收集、应用设计、专家验证与修改、试验4个阶段。结果:PURE应用程序有五个功能,从疼痛筛查到锻炼。试验结果表明,PURE App应用程序可有效减轻青少年痛经患者的月经疼痛。治疗组疼痛评分由4.48±0.71降至1.98±1.49 (p<0.001)。治疗组测量后疼痛评分与对照组比较差异有统计学意义,分别为1.98±1.49和4.90±1.10。结论:PURE App有利于青少年,尤其是原发性痛经患者。这个应用程序将使青少年更容易克服痛苦,因为应用程序上的练习可以随时随地访问。
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引用次数: 0
Models of antenatal classes for pregnant mothers 孕妇产前培训班模式
Pub Date : 2022-04-30 DOI: 10.30595/medisains.v20i1.12820
A. Sriatmi, S. Suwitri, Z. Shaluhiyah, S. Nugraheni
Introduction: Although it has proven to be helpful, the attendance of pregnant mothers in Antenatal Classes (AC) was still low, so an ineffective breakthrough application of AC was needed according to the mother's wishes and interests.Objective: The study aimed to compare various models of practical AC for pregnant mothers to improve behavior prevention of high-risk pregnancies.Method: This study is quasi-experimental with a nonequivalent control group and pre-posttest design. The population of all pregnant mothers in Semarang City, with 181 samples, was divided into three groups (Extended, Virtual and Conventional). Measurements were carried out four times to see the mean score increasing, and the results of the last measurement were analyzed using the One Way ANOVA test to compare the effectiveness of these three groups.Results: There was an increase in the mean value of all dimensions of the behavior of high-risk prevention based on its measurement stages. The extended model has the highest improvement, followed by the Virtual model. Statistically, there was a better chance in all behavioral dimensions after the intervention. There were differences in all dimensions of maternal behavior between the extended and the conventional model. In contrast, only knowledge and practice differed in the virtual model but not in attitudes, beliefs, and intentions.Conclusion: Extended and virtual models of AC effectively improved high-risk prevention behaviors better than conventional models. Although the increase was not as high as the extended model, the virtual model has an excellent opportunity to be developed as a strategy to overcome time constraints for mothers and health providers.
导读:虽然已被证明是有帮助的,但孕妇在产前班(AC)的出勤率仍然很低,因此需要根据母亲的意愿和兴趣进行无效的突破性应用。目的:比较不同型号的实用AC对孕妇高危妊娠行为的预防作用。方法:本研究采用准实验设计,采用非等效对照组和前后测试设计。三宝垄市所有孕妇人口共有181个样本,分为三组(扩展组、虚拟组和常规组)。测量进行了四次,看到平均得分增加,最后一次测量的结果使用One Way ANOVA检验来比较这三组的有效性。结果:高危预防行为各维度各测量阶段的均值均有增加。扩展模型的改进幅度最大,其次是虚拟模型。统计上,干预后在所有行为维度上都有更好的机会。扩展模型和传统模型在母亲行为的所有维度上都存在差异。相比之下,只有知识和实践在虚拟模型中不同,而在态度、信念和意图上没有差异。结论:AC扩展模型和虚拟模型比常规模型更有效地改善了高危预防行为。虽然增幅不如扩展模式高,但虚拟模式有很好的机会作为一种战略加以发展,以克服母亲和保健提供者的时间限制。
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引用次数: 0
Calcium supplementation from chicken eggshells to increase nitric oxide levels and control blood pressure in gestational hypertension 从鸡蛋壳中补充钙以增加一氧化氮水平和控制妊娠期高血压的血压
Pub Date : 2022-04-30 DOI: 10.30595/medisains.v20i1.13378
Aulia Agyanti Rahmah, S. Hadisaputro, EnyRetna Ambarwati
Background: Hypertension is one of the highest causes of death in pregnant women. Calcium deficiency can lead to hypertension. Chicken eggshell can be used as a natural calcium supplementation therapy in hypertension.Purpose: Analyze the effect of chicken eggshell on blood pressure through the increased nitric oxide level in gestational hypertension.Methods: This is Quasy experiment research with pretest and posttest with control group design. Respondents were ≥20 weeks pregnant women with gestational hypertension. Determination of respondents by purposive sampling obtained experimental group (n=12) and control group (n=12). 1.1 g/day of eggshell flour was given for 14 days.Result: Mean of systolic and diastolic blood pressure in experimental group decreased 14.25 mmHg or 9.5% (p=0.000) and 12.84 mmHg or 13.04% (p=0.000) after received chicken eggshell flour for 14 days compared to control group mean of systolic and diastolic blood pressure increased 1.92 mmHg or 1.35% (p=0.000) and 0.33 mmHg or 0,34% (p=0.121). Nitrit oxide level of experimental group increased 8.250 μmol/L or 20.93% (p=0.020) and control group decreased 3.083 μmol/L or 7.20% (p=0.488).Conclusion: Chicken eggshell flour affects increasing nitric oxide levels and controls systolic and diastolic blood pressure in gestational hypertension.
背景:高血压是孕妇死亡的最高原因之一。缺钙会导致高血压。鸡蛋壳可作为高血压的天然补钙疗法。目的:通过妊娠期高血压患者一氧化氮水平升高,分析蛋壳对血压的影响。方法:采用前测和后测相结合的Quasy实验研究,采用对照组设计。受试者为妊娠期高血压≥20周的孕妇。通过有目的的抽样确定受访者,获得实验组(n=12)和对照组(n=12中)。给予1.1g/天的蛋壳粉14天。结果:与对照组相比,实验组在服用蛋壳粉14天后收缩压和舒张压分别下降14.25 mmHg或9.5%(p=0.000)和12.84 mmHg或13.04%(p=0.0008.250μmol/L或20.93%(p=0.020),对照组降低3.083μmol/L或7.20%(p=0.0488)。
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引用次数: 0
In vivo study of cardioprotective effect of bay leaf (Syzygium polyanthum) extract 月桂叶提取物心脏保护作用的体内研究
Pub Date : 2022-04-30 DOI: 10.30595/medisains.v20i1.12502
Refi Ikhtiari, Laura Kartika Sari, A. N. Nasution, C. Ginting, Erwin Handoko, I. Lister
Background: The excessive use of chemotherapy drugs such as doxorubicin might induce cardiovascular diseases. Heart-specific biomarker enzymes such as LDH and BNP indicated the early signs of cardiotoxicity. However, there is no report on the effect of bay leaf on LDH and BNP nor its bioactive compounds and histopathology analysis.Objective: This study aims to determine the cardioprotective effect of Ethanol Extract of Bay Leaf (EEBL) based on phytochemical analysis, LDH and BNP levels, and cardiac histology of rats administered with doxorubicin.Methods: About 24 Wistar rats were divided into six groups treated with 100 mg/kg BW, 300 mg/kg BW, and 500 mg/kg BW of EEBL with CMC-Na 0.5 %, vitamin E, and doxorubicin. Preconditioning was 14 days, followed by 21 days of intraperitoneal administration. LDH and BNP parameters were measured on days 1st, 7th, 14th, and 20th. Histology analysis was conducted on day 21st.Results: Dark green EEBL showed sufficient physical quality and properties for practical application in pharmacy. EEBL has significantly affected LDH, BNP, and cardio recovery dose-dependent. The most effective doses were observed at 500 mg/kg BW, and its performance is not statistically different from those of the commercial vitamin E. The histopathological images revealed significant improvements in interstitial edema, wavy fibers, hemorrhage, intracellular vacuole, and inflammatory cell infiltration. Here we report six bioactive compounds obtained from EEBL have cardioprotective effects; Neophytadiene, squalane, phytol, methyl palmitate, stigmasterol, and  9,12-Octadecanoic acid methyl ester.Conclusion: This study has shown the promising potential of bay leaf extract as a cardioprotector with sufficient quality pharmacological standards.
背景:化疗药物如阿霉素的过量使用可能诱发心血管疾病。心脏特异性生物标志物酶如LDH和BNP表明心脏毒性的早期迹象。然而,目前还没有关于月桂叶对LDH和BNP的影响的报道,也没有关于其生物活性化合物和组织病理学分析的报道。目的:本研究旨在通过植物化学分析、LDH和BNP水平以及阿霉素给药大鼠的心脏组织学,来确定月桂叶乙醇提取物(EEBL)的心脏保护作用。方法:将约24只Wistar大鼠分为6组,分别用100 mg/kg、300 mg/kg和500 mg/kg的EEBL加0.5%羧甲基纤维素钠、维生素E和阿霉素处理。预处理为14天,然后腹膜内给药21天。在第1天、第7天、第14天和第20天测量LDH和BNP参数。第21天进行组织学分析。结果:深绿色EEBL具有足够的物理质量和性能,可在药学上实际应用。EEBL显著影响LDH、BNP和心功能恢复的剂量依赖性。观察到最有效的剂量是500 mg/kg BW,其性能与商业维生素E没有统计学差异。组织病理学图像显示间质水肿、波状纤维、出血、细胞内液泡和炎症细胞浸润有显著改善。在此,我们报道了从EEBL中获得的六种生物活性化合物具有心脏保护作用;新植酸酶、角鲨烷、植物醇、棕榈酸甲酯、豆甾醇和9,12-十八烷酸甲酯。结论:本研究显示月桂叶提取物作为一种具有足够质量药理学标准的心脏保护剂具有很好的潜力。
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引用次数: 0
Development of an electronic measuring device for body weight and nutritional status for children under two years old 研制两岁以下儿童体重和营养状况电子测量装置
Pub Date : 2022-04-30 DOI: 10.30595/medisains.v20i1.13143
Naimah Nasution, M. Widyawati, D. Ramlan
Background: Measurement of body weight and nutritional status in children under two years are still used manuals. Besides that, there is no tool to measure nutritional status, so it is necessary to develop a tool to make it easier.Purpose: The study aims to develop and test a measuring device for weight and nutritional status in children under two years.Methods: This study is Research and Development (R&D). It consisted of 5 stages, stage I (literature study), stage II (product development), stage III (expert validity and phase I trials), stage IV (product revision and final product), and stage V (phase II trials).Result: The electronic measuring device for weight and nutritional status has been created. The result is that the tool effectively determines the weight and nutritional status. The average value of tool testing is below 5%, which means the calibration value of the tool's sensitivity is valid in determining body weight. In addition, it can also determine nutritional status with a p=0,65, which means that there is no difference between measuring nutritional status using the tool and manually.Conclusion: The electronic measuring device effectively determines the weight and nutritional status.
背景:两岁以下儿童体重和营养状况的测量仍在使用手册。此外,目前还没有衡量营养状况的工具,因此有必要开发一种工具,使其更容易。目的:本研究旨在开发和测试一种两岁以下儿童体重和营养状况的测量装置。方法:本研究为研究与开发(R&D)。它包括5个阶段,第一阶段(文献研究)、第二阶段(产品开发)、第三阶段(专家效度和第一阶段试验)、第四阶段(产品修订和最终产品)和第五阶段(第二阶段试验)。结果:研制了体重和营养状况电子测量装置。结果是,该工具有效地确定了体重和营养状况。刀具测试的平均值在5%以下,说明刀具灵敏度的校准值在测定体重时是有效的。此外,它还可以确定营养状况,p=0,65,这意味着使用工具和手动测量营养状况没有区别。结论:该电子测量装置可有效测定体重和营养状况。
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引用次数: 0
From global to local action: rise from the pandemic, an efforts to increase routine immunization coverage 从全球行动到地方行动:从大流行中崛起,努力提高常规免疫覆盖率
Pub Date : 2022-04-30 DOI: 10.30595/medisains.v20i1.13586
D. Purwito
Since the first vaccine was developed (1796; smallpox vaccine), the world has seen its impact on health and well-being. Vaccines are one of the most influential scientific innovations of all time, helping to protect generations of people from infectious diseases throughout their lives. Parents need not worry too much about their children suffering from a deadly disease that has plagued previous generations because of vaccines. However, a top-down approach is needed so that vaccination becomes necessary for every people worldwide.
自从第一种疫苗被研制出来(1796年;天花疫苗),世界已经看到了它对健康和福祉的影响。疫苗是有史以来最具影响力的科学创新之一,有助于保护几代人在其一生中免受传染病的侵害。父母不必过于担心他们的孩子会因为疫苗而患上一种致命的疾病,这种疾病一直困扰着前几代人。然而,需要一种自上而下的方法,使全世界每个人都有必要接种疫苗。
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引用次数: 1
Frailty among hemodialysis patients 血液透析患者的虚弱
Pub Date : 2022-04-30 DOI: 10.30595/medisains.v20i1.12374
G. S. Adi, Eri Purba Utomo
Introduction: Hemodialysis patients have physical vulnerability due to the progressive decline of the body's systems. The physical changes in the patients can lead to haemostatics failure, known as frailty syndrome. The frail condition can cause maladaptive psychological responses due to changes that can cause anxiety in patients.Objective: This study aims to determine the prevalence of frailty in hemodialysis patients and to find out the different factor that correlates in frailty patients undergoing hemodialysis therapy.Method: This is a cross-sectional study involving 55 respondents who underwent hemodialysis therapy at the Jember Klinik Hospital. The instruments used in this study were the Edmonton Frail Scale (EFS) and the Hamilton Anxiety Rating Scale. Results: Moderate frailty was found in 23 patients (41.8%), followed by mild frailty in 18 patients (32.7%) and severe frailty in 14 patients (25.5%). In terms of anxiety, 18 patients (32.7%) had severe anxiety, 20 had moderate anxiety (36.4%), 12 (21.8%) had mild anxiety, and the other 7 (12.7%) were not anxious. The statistical analysis shows a significant difference in the average level of anxiety and the frailty status (p<0.001) among the patients. Conclusion: Frailty was highly prevalent in hemodialysis patients and had relations with anxiety and different sociodemographic characteristics of patients. The assessment of frailty should be considered when clinicians intervene and prevent worsening in patients.
引言:血液透析患者由于身体系统的逐渐衰退而存在身体脆弱性。患者的身体变化可能导致止血失败,称为虚弱综合征。虚弱的情况会导致适应不良的心理反应,因为这些变化会导致患者焦虑。目的:本研究旨在确定血液透析患者虚弱的患病率,并找出接受血液透析治疗的虚弱患者的不同相关因素。方法:这是一项横断面研究,涉及55名在詹伯·克林尼克医院接受血液透析治疗的受访者。本研究中使用的工具是埃德蒙顿虚弱量表(EFS)和汉密尔顿焦虑评定量表。结果:中度虚弱23例(41.8%),其次是轻度虚弱18例(32.7%)和重度虚弱14例(25.5%)。在焦虑方面,18例(31.7%)有严重焦虑,20例有中度焦虑(36.4%),12例(21.8%)有轻度焦虑,其余7例(12.7%)无焦虑。统计分析显示,患者的平均焦虑水平和虚弱状态存在显著差异(p<0.001)。结论:虚弱在血液透析患者中非常普遍,并与患者的焦虑和不同的社会人口学特征有关。当临床医生进行干预并防止患者病情恶化时,应考虑对虚弱的评估。
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引用次数: 0
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Medisains
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