{"title":"New-onset diabetes in COVID-19: An emerging threat to global health","authors":"T. Sathish","doi":"10.4103/jncd.jncd_83_22","DOIUrl":"https://doi.org/10.4103/jncd.jncd_83_22","url":null,"abstract":"","PeriodicalId":52935,"journal":{"name":"International Journal of Noncommunicable Diseases","volume":"7 1","pages":"196 - 197"},"PeriodicalIF":0.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41356876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of newer technologies in cancer research and its management","authors":"R. Kapoor","doi":"10.4103/jncd.jncd_95_22","DOIUrl":"https://doi.org/10.4103/jncd.jncd_95_22","url":null,"abstract":"","PeriodicalId":52935,"journal":{"name":"International Journal of Noncommunicable Diseases","volume":"7 1","pages":"147 - 151"},"PeriodicalIF":0.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42724281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Monica Gupta, Ruchika Saini, S. Jaswal, S. Lehl, Gautam Jesrani, Samiksha Gupta
Background: The risk of developing type 2 diabetes mellitus (T2DM) and associated metabolic abnormalities is higher in adult offspring of patients with T2DM. Various genetic and environmental influences play a facilitatory role. These determinants can lead to the early onset of hyperglycemia, unrecognized end-organ changes, and cardiovascular morbidity. Objective: The objective of this study was to identify the presence of undiagnosed diabetes and prediabetes in the otherwise healthy adult offspring of patients with T2DM and to study early metabolic abnormalities among these individuals. Materials and Methods: The study population consisted of 100 healthy offspring aged 18 years and above, of parents with T2DM, enrolled from the medicine outpatient area. Anthropometric characteristics, routine investigations and diabetes defining parameters, fasting plasma insulin, and homeostatic model assessment-estimated insulin resistance (HOMA-IR) were assessed. Results: The age and body mass index of participants were 32.30 ± 9.33 years and 25.08 ± 4.58 kg/m2, respectively. About 33.3% of males and 76.4% of females had abnormal waist circumference and metabolic syndrome was found in 26% of the offspring. Twenty-eight participants displayed dysglycemia, of which 10 were diagnosed with prediabetes and 18 with diabetes. C-reactive protein, total cholesterol, triglyceride values, apolipoprotein A, B, and their ratio, and HOMA-IR were significantly raised, and high-density lipoprotein was found significantly low in patients with this newly diagnosed T2DM. Conclusion: A significant number of asymptomatic offspring of patients with T2DM have incipient diabetes and prediabetes status, which is unidentified. Further, metabolic parameters are more deranged in those with newly diagnosed diabetes and prediabetes. Therefore, opportunistic screening for these offspring should be done routinely.
{"title":"Prevalence of risk factors for diabetes in adult offspring of type 2 diabetes mellitus patients","authors":"Monica Gupta, Ruchika Saini, S. Jaswal, S. Lehl, Gautam Jesrani, Samiksha Gupta","doi":"10.4103/jncd.jncd_82_22","DOIUrl":"https://doi.org/10.4103/jncd.jncd_82_22","url":null,"abstract":"Background: The risk of developing type 2 diabetes mellitus (T2DM) and associated metabolic abnormalities is higher in adult offspring of patients with T2DM. Various genetic and environmental influences play a facilitatory role. These determinants can lead to the early onset of hyperglycemia, unrecognized end-organ changes, and cardiovascular morbidity. Objective: The objective of this study was to identify the presence of undiagnosed diabetes and prediabetes in the otherwise healthy adult offspring of patients with T2DM and to study early metabolic abnormalities among these individuals. Materials and Methods: The study population consisted of 100 healthy offspring aged 18 years and above, of parents with T2DM, enrolled from the medicine outpatient area. Anthropometric characteristics, routine investigations and diabetes defining parameters, fasting plasma insulin, and homeostatic model assessment-estimated insulin resistance (HOMA-IR) were assessed. Results: The age and body mass index of participants were 32.30 ± 9.33 years and 25.08 ± 4.58 kg/m2, respectively. About 33.3% of males and 76.4% of females had abnormal waist circumference and metabolic syndrome was found in 26% of the offspring. Twenty-eight participants displayed dysglycemia, of which 10 were diagnosed with prediabetes and 18 with diabetes. C-reactive protein, total cholesterol, triglyceride values, apolipoprotein A, B, and their ratio, and HOMA-IR were significantly raised, and high-density lipoprotein was found significantly low in patients with this newly diagnosed T2DM. Conclusion: A significant number of asymptomatic offspring of patients with T2DM have incipient diabetes and prediabetes status, which is unidentified. Further, metabolic parameters are more deranged in those with newly diagnosed diabetes and prediabetes. Therefore, opportunistic screening for these offspring should be done routinely.","PeriodicalId":52935,"journal":{"name":"International Journal of Noncommunicable Diseases","volume":"7 1","pages":"177 - 182"},"PeriodicalIF":0.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42464028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The biological functioning of adiponectin (APN) has been well understood for two decades. Numerous clinical and animal studies have paved an understanding of the exposed physiological functions of APN in obesity and its related disorders. APN mediates its action through its receptors to achieve its function. Apart from its contribution to metabolism, APN also defends the cells from cell death and decreases the inflammation in various cell types through receptor-dependent mechanisms and also contributes to the reproductive function. APN communicates between adipose tissue and other organs and hence is a potential therapeutic target for obesity and its related pathogenesis.
{"title":"Adiponectin: A reliable marker","authors":"Geetha Bhaktha, S. Nayak B, M. Shantaram","doi":"10.4103/jncd.jncd_77_22","DOIUrl":"https://doi.org/10.4103/jncd.jncd_77_22","url":null,"abstract":"The biological functioning of adiponectin (APN) has been well understood for two decades. Numerous clinical and animal studies have paved an understanding of the exposed physiological functions of APN in obesity and its related disorders. APN mediates its action through its receptors to achieve its function. Apart from its contribution to metabolism, APN also defends the cells from cell death and decreases the inflammation in various cell types through receptor-dependent mechanisms and also contributes to the reproductive function. APN communicates between adipose tissue and other organs and hence is a potential therapeutic target for obesity and its related pathogenesis.","PeriodicalId":52935,"journal":{"name":"International Journal of Noncommunicable Diseases","volume":"7 1","pages":"152 - 160"},"PeriodicalIF":0.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45452427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Banerjee, D. Dutt, I. Saha, B. Paul, A. Lachyan
Background: Noncommunicable diseases (NCDs) are increasing, for which some behavioral risk factors are major concerns. mHealth has been found to be effective in changing these behavioral patterns. Objective: To assess effectiveness of mHealth technology in modification of dietary habits and physical activity, among individuals having NCDs or their risk factors, in primary healthcare settings in South East Asian Region Countries. Materials and Methods: A systematic review and meta-analysis was done with the primary outcome as effectiveness of mHealth for improving dietary practices and increasing physical activity. Articles were retrieved from PubMed, Cochrane Central, Google Scholar, and Pre-print servers followed by forward and backward searching. Quality and risk of bias of included studies were assessed. Meta-analysis was performed using RevMan v. 5.4.1 software. Heterogeneity was tested using χ2 test and measured using I2 statistic, with Forest plots as the final outcome. Results: Nine publications from seven studies, of which seven were conducted in India and two in Bangladesh, qualified for the review. All studies used varied mHealth interventions. Most studies reported beneficial effects in reducing inadequate/improper diet and insufficient/improving physical activity, at community/workplace settings, except two studies reporting no apparent impact, both being from Bangladesh. Meta-analysis revealed statistically significant differences between intervention and control groups for pooled estimates of reduced dietary energy and increased fruits/vegetables. Although heterogeneity is absent between studies considered for fruits/vegetables, both studies were compromised in quality and bias. Studies on dietary energy intake had high statistical heterogeneity, in addition to having high risk of bias. Hence, the results need to be interpreted with caution. No effect was observed on increasing physical activity. Conclusion: mHealth interventions have huge potential to facilitate behavior change. However, more research is needed before its potential scale-up.
{"title":"Effectiveness of mHealth for modification of dietary habits and physical activity among individuals at risk or suffering from noncommunicable diseases in primary healthcare settings in South East Asian Region countries – A systematic review and meta-analysis","authors":"B. Banerjee, D. Dutt, I. Saha, B. Paul, A. Lachyan","doi":"10.4103/jncd.jncd_59_22","DOIUrl":"https://doi.org/10.4103/jncd.jncd_59_22","url":null,"abstract":"Background: Noncommunicable diseases (NCDs) are increasing, for which some behavioral risk factors are major concerns. mHealth has been found to be effective in changing these behavioral patterns. Objective: To assess effectiveness of mHealth technology in modification of dietary habits and physical activity, among individuals having NCDs or their risk factors, in primary healthcare settings in South East Asian Region Countries. Materials and Methods: A systematic review and meta-analysis was done with the primary outcome as effectiveness of mHealth for improving dietary practices and increasing physical activity. Articles were retrieved from PubMed, Cochrane Central, Google Scholar, and Pre-print servers followed by forward and backward searching. Quality and risk of bias of included studies were assessed. Meta-analysis was performed using RevMan v. 5.4.1 software. Heterogeneity was tested using χ2 test and measured using I2 statistic, with Forest plots as the final outcome. Results: Nine publications from seven studies, of which seven were conducted in India and two in Bangladesh, qualified for the review. All studies used varied mHealth interventions. Most studies reported beneficial effects in reducing inadequate/improper diet and insufficient/improving physical activity, at community/workplace settings, except two studies reporting no apparent impact, both being from Bangladesh. Meta-analysis revealed statistically significant differences between intervention and control groups for pooled estimates of reduced dietary energy and increased fruits/vegetables. Although heterogeneity is absent between studies considered for fruits/vegetables, both studies were compromised in quality and bias. Studies on dietary energy intake had high statistical heterogeneity, in addition to having high risk of bias. Hence, the results need to be interpreted with caution. No effect was observed on increasing physical activity. Conclusion: mHealth interventions have huge potential to facilitate behavior change. However, more research is needed before its potential scale-up.","PeriodicalId":52935,"journal":{"name":"International Journal of Noncommunicable Diseases","volume":"7 1","pages":"161 - 176"},"PeriodicalIF":0.4,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48358191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-19DOI: 10.1101/2022.08.18.22278928
W. Ng'ambi, T. Mwase, J. Chinkhumba, M. Udedi, F. Chigaru, J. C. Banda, D. Nkhoma, J. Mfutso-Bengo
Introduction: By 2030, the non-communicable diseases (NCDs) are expected to overtake communicable, maternal, neonatal, and nutritional (CMNN) diseases combined as the leading cause of mortality in sub-Saharan Africa (SSA). With the increasing trend in NCDs, the NCD risk factors (NCDRF) need to be understood at local level in order to guide NCD risk mitigation efforts. Therefore, we provide a detailed analysis of some modifiable NCDRF and their determinants in Malawi using the 2017 Stepwise survey (STEPS). Methods: This is a secondary analysis of the Malawi 2017 STEPS. Data was analysed using frequencies, proportions, odds ratios (OR) and their associated 95% confidence intervals (95%CI). We fitted multiple logistic regression of the NCD risk factors on the explanatory variables using likelihood ratio test. The level of statistical significance was set at P< 0.05. Results: Of the 4187 persons, 9% were current smokers, 1% were taking alcohol, 16% had high salt intake, 64% had insufficient fruit intake, 21% had low physical activity, 25% had high blood sugar, and 11% had high blood pressure. Smoking odds increased with age but decreased with level of education. Females had lower odds of engaging in harmful alcohol use than males (AOR=0.04, 95%CI: 0.01-0.17, P<0.001). Females had lower odds of high salt uptake than the males (AOR=0.70, 95%CI: 0.58-0.84, P=0.0001). Persons in non-paid jobs had higher odds of salt uptake than those employed (AOR=1.70, 95%CI: 1.03-2.79, P=0.04). Females were 22% more likely to have insufficient fruit uptake compared to males (AOR=1.22, 95%CI: 1.06-1.41, P=0.007). Conclusion: The high prevalence of physical inactivity, high salt consumption, insufficient fruit intake, raised blood glucose and high relatively blood pressure calls for a sound public health approach. The Malawi Ministry of Health should devise multi-sectoral approaches that minimize exposure to modifiable NCD risk factors at population and individual levels.
{"title":"Prevalence of non-communicable diseases risk factors and their determinants in Malawi: Evidence from 2017 WHO STEPwise Survey","authors":"W. Ng'ambi, T. Mwase, J. Chinkhumba, M. Udedi, F. Chigaru, J. C. Banda, D. Nkhoma, J. Mfutso-Bengo","doi":"10.1101/2022.08.18.22278928","DOIUrl":"https://doi.org/10.1101/2022.08.18.22278928","url":null,"abstract":"Introduction: By 2030, the non-communicable diseases (NCDs) are expected to overtake communicable, maternal, neonatal, and nutritional (CMNN) diseases combined as the leading cause of mortality in sub-Saharan Africa (SSA). With the increasing trend in NCDs, the NCD risk factors (NCDRF) need to be understood at local level in order to guide NCD risk mitigation efforts. Therefore, we provide a detailed analysis of some modifiable NCDRF and their determinants in Malawi using the 2017 Stepwise survey (STEPS). Methods: This is a secondary analysis of the Malawi 2017 STEPS. Data was analysed using frequencies, proportions, odds ratios (OR) and their associated 95% confidence intervals (95%CI). We fitted multiple logistic regression of the NCD risk factors on the explanatory variables using likelihood ratio test. The level of statistical significance was set at P< 0.05. Results: Of the 4187 persons, 9% were current smokers, 1% were taking alcohol, 16% had high salt intake, 64% had insufficient fruit intake, 21% had low physical activity, 25% had high blood sugar, and 11% had high blood pressure. Smoking odds increased with age but decreased with level of education. Females had lower odds of engaging in harmful alcohol use than males (AOR=0.04, 95%CI: 0.01-0.17, P<0.001). Females had lower odds of high salt uptake than the males (AOR=0.70, 95%CI: 0.58-0.84, P=0.0001). Persons in non-paid jobs had higher odds of salt uptake than those employed (AOR=1.70, 95%CI: 1.03-2.79, P=0.04). Females were 22% more likely to have insufficient fruit uptake compared to males (AOR=1.22, 95%CI: 1.06-1.41, P=0.007). Conclusion: The high prevalence of physical inactivity, high salt consumption, insufficient fruit intake, raised blood glucose and high relatively blood pressure calls for a sound public health approach. The Malawi Ministry of Health should devise multi-sectoral approaches that minimize exposure to modifiable NCD risk factors at population and individual levels.","PeriodicalId":52935,"journal":{"name":"International Journal of Noncommunicable Diseases","volume":"1 1","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48015562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shalini Bassi, Tina Rawal, G. Nazar, P. Dhore, A. Bhatt, S. Deshpande, A. Unnikrishnan, M. Arora
Background: Diabetes is quickly reaching the status of a potential epidemic, with more than 74.2 million Indians diagnosed with the disease. With the majority of India's population residing in rural areas, the potential burden of diabetes is compounded by rising healthcare expenses, lower literacy, lack of awareness, limited access, and availability of healthcare. Objective: The process evaluation of project diabetes with dignity (DWD) aimed to test the feasibility and effectiveness of a model of enhanced diabetes care for adults, empowering Accredited Social Health Activists (ASHAs) in rural communities of Pune, Maharashtra. Methods: A community-based, quasi-experimental study was conducted with high-risk identified adults with Type 2 diabetes (n = 431, 30–70 years), in two Primary Health Centers of Baramati block of Pune district. ASHAs implemented six months' DWD intervention, including screening of subjects at risk of Type 2 diabetes using Indian diabetes risk score questionnaire, random blood glucose testing using glucometer, counseling, monthly house-to-house visits, and community-based awareness-raising activities about diabetes care-related issues. Results: Results indicated that the delivery, and reach of DWD intervention were favorable. The intervention was delivered as intended with a high degree of fidelity with dosage delivery, high attendance, and good participation rates. The participants were satisfied with intervention strategies activities and recognized to scale it up further. The engagement of ASHAs as a protagonist in the successful project implementation was emphasized. Conclusions: The findings on DWD intervention satisfaction, reach, and participation favored the capacity-building of ASHAs for diabetes screening, prevention, management, and referrals in rural Indian settings.
{"title":"Empowering Accredited Social Health Activist (ASHA) in a rural communities of Pune (Maharashtra): Process evaluation of a community-based intervention for diabetes care","authors":"Shalini Bassi, Tina Rawal, G. Nazar, P. Dhore, A. Bhatt, S. Deshpande, A. Unnikrishnan, M. Arora","doi":"10.4103/jncd.jncd_15_22","DOIUrl":"https://doi.org/10.4103/jncd.jncd_15_22","url":null,"abstract":"Background: Diabetes is quickly reaching the status of a potential epidemic, with more than 74.2 million Indians diagnosed with the disease. With the majority of India's population residing in rural areas, the potential burden of diabetes is compounded by rising healthcare expenses, lower literacy, lack of awareness, limited access, and availability of healthcare. Objective: The process evaluation of project diabetes with dignity (DWD) aimed to test the feasibility and effectiveness of a model of enhanced diabetes care for adults, empowering Accredited Social Health Activists (ASHAs) in rural communities of Pune, Maharashtra. Methods: A community-based, quasi-experimental study was conducted with high-risk identified adults with Type 2 diabetes (n = 431, 30–70 years), in two Primary Health Centers of Baramati block of Pune district. ASHAs implemented six months' DWD intervention, including screening of subjects at risk of Type 2 diabetes using Indian diabetes risk score questionnaire, random blood glucose testing using glucometer, counseling, monthly house-to-house visits, and community-based awareness-raising activities about diabetes care-related issues. Results: Results indicated that the delivery, and reach of DWD intervention were favorable. The intervention was delivered as intended with a high degree of fidelity with dosage delivery, high attendance, and good participation rates. The participants were satisfied with intervention strategies activities and recognized to scale it up further. The engagement of ASHAs as a protagonist in the successful project implementation was emphasized. Conclusions: The findings on DWD intervention satisfaction, reach, and participation favored the capacity-building of ASHAs for diabetes screening, prevention, management, and referrals in rural Indian settings.","PeriodicalId":52935,"journal":{"name":"International Journal of Noncommunicable Diseases","volume":"7 1","pages":"63 - 70"},"PeriodicalIF":0.4,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42462265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Sharma, N. Goel, S. Lehl, D. Walia, S. Puri, Kritee Shukla, Shreyas Mishra
Introduction: Hypertension is a chronic disease that needs to be treated adequately. Nonadherence to antihypertensive medicines can lead to coronary heart disease and stroke complications. The present study assessed the prevalence and predictors of medication nonadherence among hypertensive patients. Methodology: A cross-sectional study was conducted among hypertensive patients visiting the outdoor patient department of a tertiary care hospital in North India. Trained investigators interviewed the study participants after obtaining their written informed consent. A validated tool, namely the Brief Medication Questionnaire, was used to assess the medication nonadherence. Statistical analyses were performed using the Epi Info version for Windows. Results: A total of 400 hypertensive patients participated in the study. The mean age of study participants was 62.8 years (standard deviation = 11.0). Around half (55.0%) of the hypertensive patients suffered from comorbid disease conditions. The prevalence of antihypertensive medication nonadherence was 23.8%. The logistic regression model revealed that patients having a shorter duration of hypertension (odds ratio = 2.2 [1.2–3.9]) and those living in a joint family (odds ratio = 1.7 [1.1–2.8]) had higher medication nonadherence, as compared to their counterparts. Conclusion: Nearly one-fifth of the study participants were nonadherent to their antihypertension medication. There is a need for designing and implementing effective strategies by health-care providers for increasing antihypertensive medication adherence.
{"title":"Prevalence and predictors of medication nonadherence among hypertensive patients","authors":"D. Sharma, N. Goel, S. Lehl, D. Walia, S. Puri, Kritee Shukla, Shreyas Mishra","doi":"10.4103/jncd.jncd_11_22","DOIUrl":"https://doi.org/10.4103/jncd.jncd_11_22","url":null,"abstract":"Introduction: Hypertension is a chronic disease that needs to be treated adequately. Nonadherence to antihypertensive medicines can lead to coronary heart disease and stroke complications. The present study assessed the prevalence and predictors of medication nonadherence among hypertensive patients. Methodology: A cross-sectional study was conducted among hypertensive patients visiting the outdoor patient department of a tertiary care hospital in North India. Trained investigators interviewed the study participants after obtaining their written informed consent. A validated tool, namely the Brief Medication Questionnaire, was used to assess the medication nonadherence. Statistical analyses were performed using the Epi Info version for Windows. Results: A total of 400 hypertensive patients participated in the study. The mean age of study participants was 62.8 years (standard deviation = 11.0). Around half (55.0%) of the hypertensive patients suffered from comorbid disease conditions. The prevalence of antihypertensive medication nonadherence was 23.8%. The logistic regression model revealed that patients having a shorter duration of hypertension (odds ratio = 2.2 [1.2–3.9]) and those living in a joint family (odds ratio = 1.7 [1.1–2.8]) had higher medication nonadherence, as compared to their counterparts. Conclusion: Nearly one-fifth of the study participants were nonadherent to their antihypertension medication. There is a need for designing and implementing effective strategies by health-care providers for increasing antihypertensive medication adherence.","PeriodicalId":52935,"journal":{"name":"International Journal of Noncommunicable Diseases","volume":"7 1","pages":"71 - 75"},"PeriodicalIF":0.4,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43136185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Krishnamachari Srinivasan, Luke Joshua Salazar, Elsa Heylen, Maria L Ekstrand
We examined the association of elevated concentration of total homocysteine (tHcy) with the severity of depression in patients diagnosed with depression and comorbid chronic medical conditions in rural primary care settings in Karnataka. Participants were included from the control arm of a cluster-randomized controlled trial designed to evaluate the effects of using a collaborative care model to integrate screening and treatment of primary health center patients. tHcy was assayed at baseline, and depression severity scores were assessed using the Patient Health Questionnaire (PHQ-9) 6 months later. There was no difference in the mean PHQ-9 score between those with (mean PHQ = 7.4) and without (mean PHQ = 7.6) elevated tHcy levels (P = 0.67).
{"title":"Elevated homocysteine and depression outcomes in patients with comorbid medical conditions in rural primary care.","authors":"Krishnamachari Srinivasan, Luke Joshua Salazar, Elsa Heylen, Maria L Ekstrand","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We examined the association of elevated concentration of total homocysteine (tHcy) with the severity of depression in patients diagnosed with depression and comorbid chronic medical conditions in rural primary care settings in Karnataka. Participants were included from the control arm of a cluster-randomized controlled trial designed to evaluate the effects of using a collaborative care model to integrate screening and treatment of primary health center patients. tHcy was assayed at baseline, and depression severity scores were assessed using the Patient Health Questionnaire (PHQ-9) 6 months later. There was no difference in the mean PHQ-9 score between those with (mean PHQ = 7.4) and without (mean PHQ = 7.6) elevated tHcy levels (<i>P</i> = 0.67).</p>","PeriodicalId":52935,"journal":{"name":"International Journal of Noncommunicable Diseases","volume":"7 2","pages":"95-97"},"PeriodicalIF":0.4,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10372138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We examined the association of elevated concentration of total homocysteine (tHcy) with the severity of depression in patients diagnosed with depression and comorbid chronic medical conditions in rural primary care settings in Karnataka. Participants were included from the control arm of a cluster-randomized controlled trial designed to evaluate the effects of using a collaborative care model to integrate screening and treatment of primary health center patients. tHcy was assayed at baseline, and depression severity scores were assessed using the Patient Health Questionnaire (PHQ-9) 6 months later. There was no difference in the mean PHQ-9 score between those with (mean PHQ = 7.4) and without (mean PHQ = 7.6) elevated tHcy levels (P = 0.67).
{"title":"Elevated homocysteine and depression outcomes in patients with comorbid medical conditions in rural primary care","authors":"K. Srinivasan, L. Salazar, E. Heylen, M. Ekstrand","doi":"10.4103/jncd.jncd_18_22","DOIUrl":"https://doi.org/10.4103/jncd.jncd_18_22","url":null,"abstract":"We examined the association of elevated concentration of total homocysteine (tHcy) with the severity of depression in patients diagnosed with depression and comorbid chronic medical conditions in rural primary care settings in Karnataka. Participants were included from the control arm of a cluster-randomized controlled trial designed to evaluate the effects of using a collaborative care model to integrate screening and treatment of primary health center patients. tHcy was assayed at baseline, and depression severity scores were assessed using the Patient Health Questionnaire (PHQ-9) 6 months later. There was no difference in the mean PHQ-9 score between those with (mean PHQ = 7.4) and without (mean PHQ = 7.6) elevated tHcy levels (P = 0.67).","PeriodicalId":52935,"journal":{"name":"International Journal of Noncommunicable Diseases","volume":"7 1","pages":"95 - 97"},"PeriodicalIF":0.4,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45638262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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