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Study of Traditional Drug Ethnopharmacology Used for The Treatment of Metabolic Disorders in Pamona Puselemba District 帕莫纳普塞勒巴地区治疗代谢性疾病的传统药物民族药理学研究
IF 0.4 Pub Date : 2023-07-20 DOI: 10.52365/jond.v3i1.662
A. Masyita, Arwinda Alitsia Hasyim, Yuliet Yuliet, Ritha Pratiwi
People in Pamona Puselemba Subdistrict in Poso Regency have used various plant species to maintain health and prevent various diseases, one of which is metabolic disorders. This study aims to determine the types and parts of plants, processing methods, use, duration of treatment, frequency of use, and chemical content contained in plants that are efficacious as drugs for metabolic disorders. The research was conducted descriptively using qualitative methods and the technique of taking informants (Hattra and sufferers) with the purposive sampling method. The results obtained were 32 types of plants, consisting of 24 families, for the treatment of metabolic disorders. The plant parts used were 49% leaves, 12% stems, 21% fruit, 6% tubers, 3% flowers, 3% rhizomes, 3% seeds, and 3% hair. Processing method: 77%, blended, brewed 13%, without processing 77%. How to use: drink 89%, eat directly 11%, duration of treatment 1 week, and frequency of use 2 times a day. The content of compounds contained in medicinal plants is very diverse, such as flavonoids, terpenoids, saponins, tannins, alkaloids, allisin, and other chemical compounds that can be used in the treatment of metabolic disorders. People in Pamona sub-district still use traditional medicine to treat metabolic diseases.
Poso摄政区Pamona Puselemba街道的人们使用各种植物来保持健康和预防各种疾病,其中之一是代谢紊乱。本研究旨在确定植物的种类和部位、加工方法、用途、治疗时间、使用频率以及植物中所含的化学成分对代谢紊乱有疗效的药物。本研究采用定性方法和有目的抽样的方法,采用描述性方法,并采用举报人(哈特拉和患者)的技术。结果获得治疗代谢紊乱的植物32种,隶属于24科。使用的植物部位是49%的叶子,12%的茎,21%的果实,6%的块茎,3%的花,3%的根茎,3%的种子和3%的毛。加工方法:77%,混合,酿造13%,未加工77%。使用方法:饮用89%,直接食用11%,疗程1周,使用频率每日2次。药用植物中所含化合物的含量非常多样化,如黄酮类化合物、萜类化合物、皂苷、单宁、生物碱、蒜素以及其他可用于治疗代谢紊乱的化合物。帕莫纳街道的人们仍然使用传统药物治疗代谢性疾病。
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引用次数: 0
Prediksi Toksisitas dan Farmakokinetika untuk mendapatkan Kandidat Obat Analgesik 对毒性和药理的预测,以获得任何抗镇痛药物的候选人
IF 0.4 Pub Date : 2023-05-24 DOI: 10.52365/jond.v3i1.654
Okta Nursanti, Abdul Aziz, Ginayanti Hadisoebroto
Salah satu upaya penemuan obat baru untuk mengobati nyeri yang sering terjadi di masyarakat adalah dengan penapisan senyawa bioaktif yang berasal dari alam. Flavonoid merupakan salah senyawa bioaktif alami yang memiliki berbagai khasiat dalam pengobatan seperti sebagai antibakteri, antijamur, antivirus, antioksidan, antiinflamasi, antialergi, antinyeri dan antitumor. Senyawa bioaktif yang terdapat di flavonoid yang memiliki aktivitas sebagai antinyeri seperti gingerol, linalool, limonen, zingeron, zingiberol, anthocyanin, dan melatonin. Untuk mengetahui besarnya interaksi senyawa bioaktif dengan target dilakukan dengan penapisan virtual melalui Protox II Web Server untuk mengetahui toksisitas dan PkCSM untuk mengetahui ADMET. Dari penelitian ini diperoleh seluruh senyawa uji sangat aman, terbukti dengan hasil dari toksisitas, kesamaan dan organ target.One of the efforts to find new drugs to treat pain that often occurs in the community is by screening bioactive compounds derived from nature. Flavonoids are natural bioactive compounds that have various medicinal properties such as antibacterial, antifungal, antiviral, antioxidant, anti-inflammatory, antiallergic, anti-pain, and antitumor properties. Bioactive compounds contained in flavonoids that have anti-pain activity, such as gingerol, linalool, limonen, zingeron, zingiberol, anthocyanins, and melatonin, To determine the magnitude of the interaction of bioactive compounds with targets, virtual screening was carried out through the Protox II Web Server to determine toxicity and PkCSM to determine ADMET. From this research, it was determined that all test compounds were very safe, as evidenced by the results of toxicity, similarity, and target organs.
一种用于治疗社会中常见疼痛的新药的尝试之一,就是从自然中提取一种生物活性化合物。黄酮是一种天然的生物活性化合物,具有抗菌、抗真菌药、抗病毒药、抗氧化剂、抗氧化药、抗过敏药、过敏药和镇定剂等治疗功效。在类黄酮中发现的一种生物活性化合物,如姜醇、二醇、柠檬醇、锌、锌、苯酚和褪黑素。要了解通过模态II Web服务器进行的虚拟合成作用的强度,了解毒性和PkCSM (ADMET)。从这项研究中获得了一种高度安全的化合物试验,可以证明其毒性、相似性和目标器官的结果。寻找一种新的药物来缓解社区中十次发生的疼痛的努力是通过筛选出大自然的生物活性化合物。黄麻黄素是一种天然的生物活性化合物,具有多种药物性质,如抗菌、抗fungal、抗病毒剂、抗氧化剂、抗炎药、抗过敏药、抗痛苦药和抗疼痛药等。由具有抗疼痛耐药性的物质组成的flavonoids, such as gingerol, linalool, limonen, zingiberon, zingiberin,从这项研究来看,所有的测试都是非常安全的,因为这些测试被毒性、模拟和有机微生物的结果所证明。
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引用次数: 0
Edukasi Diet DASH dalam menurunkan Tekanan Darah pada Pasien Hipertensi di Wilayah Kerja Puskesmas Kabila 在Puskesmas Kabila工作地区,DASH饮食指导高血压患者降低血压
IF 0.4 Pub Date : 2023-05-24 DOI: 10.52365/jond.v3i1.640
Fakhriatul Falah, Rista Apriana
Penyakit hipertensi merupakan penyakit tidak menular peringkat pertama terbanyak di Provinsi Gorontalo selama empat tahun berturut-turut dengan 29.391 kasus pada tahun 2020. 60% penderita hipertensi mengalami komplikasi stroke, penyakit ginjal, dan kebutaan. Hal ini disebabkan kurangnya kemampuan pasien hipertensi dalam melakukan manajemen diet. Salah satu jenis pendekatan diet yang dapat diterapkan pada pasien hipertensi adalah diet DASH (Dietary Approach to Stop Hipertension) . Tujuan kegiatan pengabdian masyarakat ini adalah meningkatkan pengetahuan pasien hipertensi terkait penerapan metode DASH dalam mengatur diet pasien hipertensi. Kegiatan pengabdian masyarakat ini dilakukan dengan metode edukasi terstruktur terhadap 20 orang pasien hipertensi. Sebelum dan setelah kegiatan, dilakukan pengukuran tekanan darah pada pasien hipertensi. Setelah kegiatan, didapatkan penurunan tekanan darah sistolik dari 159 mmHg menjadi 18 mmHg dan tekanan darah diastolik dari 91 mmHg menjadi 80 mmHg . Metode diet DASH dapat dijadikan sebagai alternatif pendekatan diet dalam menurunkan tekanan darah pada pasien hipertensi.Hypertension has been the top-ranked non-communicable disease in Gorontalo Province for four consecutive years, with 29,391 cases in 2020. 60% of hypertension sufferers experience complications from stroke, kidney disease, and blindness. This is due to the patients' lack of ability to carry out diet management. One type of dietary approach that can be applied to hypertensive patients is the DASH (Dietary Approach to Stop Hypertension) diet. The purpose of this community service activity is to increase the knowledge of hypertensive patients regarding the application of the DASH method in managing their diet. This community service activity was carried out using a structured educational method for 20 hypertension patients. Before and after the activity, blood pressure was measured in hypertensive patients. After the activity, there was a decrease in systolic blood pressure from 159 mmHg to 128 mmHg and diastolic blood pressure from 91 mmHg to 80 mmHg. The DASH diet method can be used as an alternative dietary approach to lowering blood pressure in hypertensive patients.
高血压是Gorontalo省连续四年的非传染性疾病,2020年有29391例。60%的高血压患者患有中风并发症、肾病和失明。这是由高血压患者缺乏饮食管理能力造成的。针对高血压患者的一种可行的饮食方法是饮食失调。这些社区奉献活动的目的是增加高血压患者在控制高血压患者饮食方面应用的知识。这是一项针对20名高血压患者的结构性教育活动。手术前后,为高血压患者量血压。活动结束后,收缩压从159 mmHg下降到18 mmHg,舒张压从91 mmHg下降到80 mmHg。DASH的饮食方法可以作为降低高血压患者血压的替代饮食方法。高血压一直是Gorontalo省四年内的主要非通信疾病,2020年有29391次访问。60%的退行性高血压患者经历中风、肾疾病和失明。这是有资格承担节食管理的后果。一种饮食可以应用于过度疲劳的饮食。这个社区服务的目的是增加高强度病人的知识,以补充他们饮食中的应用方法。这个社区服务的活动是用20种高强度病人的标准教育方法解决的。在行动之前和之后,血液压力被称为高血压。在行动之后,从159 mmHg到128 mmHg和舒张血液压力从91 mmHg到80 mmHg有一个decrease。低血糖的饮食方法可以用作一种替代饮食方法来治疗高血压。
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引用次数: 0
Review: Potensi Bioaktivitas Tumbuhan Alam Gambut Sebagai Bahan Baku Obat 回顾:泥炭天然植物的生物活性作为药物原料
IF 0.4 Pub Date : 2023-05-04 DOI: 10.52365/jond.v3i1.673
Muhammad Irmawan, Septaria Yolan Kalalinggi, Y. Nainggolan
Indonesia merupakan negara kepulauan di kawasan Asia Tenggara dengan sumber daya alam yang melimpah. Salah satu sumber daya alam hayati yang memiliki potensi bernilai tinggi adalah lahan gambut. Lahan gambut merupakan lahan yang terbentuk dari sisa-sisa bahan organik yang tertimbun dalam jangka waktu yang lama sehingga hanya tumbuhan tertentu yang dapat hidup di lahan tersebut. Tanah lahan gambut berbeda dengan tanah mineral, dimana lahan gambut memiliki karakteristik tersendiri sehingga hanya beberapa tumbuhan yang dapat hidup di kawasan lahan gambut. Review ini bertujuan untuk mengeksplorasi potensi tumbuhan kelakai, bajakah dan bawang dayak dari lahan gambut yang memiliki bioaktivitas untuk bahan baku obat, dengan menggunakan metode literature review. Hasil yang diperoleh menunjukkan bahwa tumbuhan tersebut memiliki bioaktivitas seperti antioksidan, antikanker, antibakteri, larvasida, afrodisiaka dan berpotensi dalam mengurangi gejala anemia. Kedepannya dilakukan penelitian lebih lanjut mengenai bioaktivitas spesifik yang dimiliki oleh tumbuhan tersebut.Indonesia is an archipelagic state in Southeast Asia with abundant natural resources. One of the biological natural resources that has high potential value is peat land. Peatland is formed from the remains of organic matter that has accumulated over a long period of time, so only certain plants can live on the land. Peatland soil is different from mineral soil peatland has its own characteristics, so only a few plants can live in peatland areas. This review aims to explore the potential of peatland peat plants, which have bioactivity as medicinal raw materials, using the literature review method. The results obtained indicate that these plants have bioactivities such as antioxidants, anticancer, antibacterial, larvicidal, and aphrodisiac properties. These plants also have the potential to reduce the symptoms of anemia. In the future, further research will be carried out regarding the specific bioactivity possessed by these plants.
印度尼西亚是东南亚的一个岛国,拥有丰富的自然资源。其中一种潜在的高价值生物资源是泥炭地。泥炭地是由长期积累的有机物质的残留物形成的,因此只有某些植物才能在土壤中生存。泥炭地不同于矿物土壤,泥炭地有其独特的特征,只有少数植物能在泥炭沼泽地区生存。该评论的目的是利用对原料进行生物活性的药物分析,探索泥炭沼泽的草本植物、犁和葱的潜力。取得的结果表明,该植物具有抗氧化剂、抗癌、抗菌、杀虫剂、春药和潜在的贫血症状。未来对该植物的特定生物活性进行进一步研究。印度尼西亚是东南部拥有天然资源的群岛国家。拥有高度潜力的有机资源是peat土地。高原是由存在已经过了一段时间的有机物的遗迹所保留的,所以只有最确定的植物才能在陆地上生存。Peatland soil和矿物soil Peatland是不同的它有自己的特点,所以只有很少的植物可以生活在Peatland地区。这项评估包括利用阅读材料检阅方法,探索可能的peatland peat plants。这些植物的结果使其具有诸如抗氧化物和抗氧化物、抗癌症、抗菌、菌属和抗氧化物性质等生物活动。这些植物还有可能减少贫血的症状。在未来,进一步的研究将考虑这些植物赋予的特殊生物活动。
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引用次数: 0
The Effect of Murottal Therapy on Blood Pressure in Elderly Patients With Hypertension at Jambidan Posyandu, Banguntapan 1 Community Health Center 在Jambidan Posyandu, Banguntapan 1社区卫生中心Murottal治疗对老年高血压患者血压的影响
IF 0.4 Pub Date : 2023-04-30 DOI: 10.52365/jond.v3i1.440
Arita Muwarni, S. Anggoro
Hypertension is a non-communicable disease that poses a threat to people in developing countries. Hypertension is a cause of death, called the silent killer, and is mostly suffered by the elderly. This is caused by physiological factors, namely decreased body function due to the aging process, so that non-communicable diseases attack many elderly people. The global health standard does not only rely on curative measures because most diseases can be prevented by healthy lifestyles and avoiding risky lifestyles. This study aims to determine the effect of murottal therapy on blood pressure in the elderly with hypertension. This study used a quasi-experimental research design using a one-group pre-post test design and a sample size of 34 elderly with the sampling technique of purposive sampling and bivariate analysis using the Wilcoxon test. The result is that murottal therapy has an effect on reducing blood pressure in elderly people with hypertension, with a Wilcoxon signed rank test p-value of 0.000 (P <0.05), so there is an effect of murottal therapy on blood pressure in the elderly with hypertension.
高血压是一种对发展中国家人民构成威胁的非传染性疾病。高血压是一种导致死亡的原因,被称为“无声的杀手”,患者多为老年人。这是由生理因素引起的,即由于衰老过程导致身体功能下降,因此非传染性疾病袭击了许多老年人。全球卫生标准不仅依赖于治疗措施,因为大多数疾病可以通过健康的生活方式和避免危险的生活方式来预防。本研究旨在探讨穆罗妥治疗对老年高血压患者血压的影响。本研究采用准实验研究设计,采用单组前后测试设计,样本量为34名老年人,采用目的抽样的抽样技术,采用Wilcoxon检验的双变量分析。结果表明,莫罗妥尔治疗对老年高血压患者血压有降低作用,Wilcoxon sign rank检验P值为0.000 (P <0.05),说明莫罗妥尔治疗对老年高血压患者血压有降低作用。
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引用次数: 0
Gambaran Implementasi Program Promosi Kesehatan Sebagai Upaya Penanggulangan Kejadian Stunting di Puskesmas Gladak Pakem 概述了在Gladak Pakem Puskesmas绝技计划的实施
IF 0.4 Pub Date : 2023-04-25 DOI: 10.52365/jond.v3i1.541
Erin Arifah Wijaya, Yennike Tri Herawati
Stunting merupakan salah satu masalah yang dapat menghambat perkembangan manusia. Prevalensi stunting di Indonesia pada tahun 2022 yaitu 21,6%. Penelitian ini dilakukan untuk menggambarkan pelaksanaan program promosi kesehatan sebagai salah satu upaya penanggulangan kejadian stunting yang terjadi di Puskemas Gladak Pakem Kabupaten Jember. Jenis penelitian ini adalah deskripstif kualitatif. Informan penelitian ini adalah Kepala Puskemas serta penanggung jawab progam promosi kesehatan di Puskemas Gladak Pakem. Teknik pengumpulan data menggunakan metode wawancara, observasi serta dokumentasi. Instrumen penelitian ini adalah lembar panduan wawancara, lembar observasi dan lembar dokumentasi. Teknik analisis data penelitian ini menggunakan teknik triangulasi. Hasil penelitian ini diperoleh bahwa pelaksanaan program promosi kesehatan sebagai upaya penanggulangan kejadian stunting yang ditinjau dari beberapa aspek menunjukkan bahwa komunikasi serta penyampaian informasi yang dilakukan pimpinan kepada para pelaksana program telah dilaksanakan dengan baik dan benar, meskipun tidak jarang terjadi kesalahpaham informasi yang disebabkan penyampaian informasi yang kurang maksimal. Para pelaksana program juga berkomitmen dengan baik dalam melaksanakan tugas yang didukung oleh sarana prasarana serta pembiayaan program yang cukup. Meskipun belum terdapat Standar Operasional Prosedur (SOP) yang menjadi pedoman pelaksanaan program tetapi Puskesmas Gladak Pakem tetap memiliki petunjuk teknis sebagai pedoman dalam melaksanakan kegiatan promosi kesehatan sebagai upaya penanggulangan kejadian stunting.Stunting is a problem that can hinder human development. The prevalence of stunting in Indonesia in 2022 will be 21.6%. This research was conducted to describe the implementation of a health promotion program as an effort to overcome stunting that occurred at the Gladak Pakem Health Center, Jember Regency. This type of research is quanlitative and descriptive. The informants of this study were the head of the public health center and the person in charge of the health promotion program at the Gladak Pakem health center. Data collection techniques using interviews, observation, and documentation. The research instruments were interview guide sheets, observation sheets, and documentation sheets. The data analysis technique used in this research is a triangulation technique. The results of this study found that the implementation of the health promotion program as an effort to overcome stunting was successful in several aspects, including the communication and delivery of information by the leadership to program implementers, although it was not uncommon for misunderstandings to occur due to misinformation not maximal. The program implementers are also well committed to carrying out their duties, supported by adequate infrastructure and program funding. Even though there is no standard operating procedures (SOP) to guide the implementation of the program, the Gladak Pakem He
替身是阻碍人类发展的问题之一。2022年印度尼西亚的特技流行是21.6%。本研究将卫生促进计划的实施描述为应对Jember区的Gladak Pakem区的任何特技活动的对策之一。这种研究是描述性的定性。本研究的线人是首席猫,也是格拉达帕克猫的健康促进计划负责人。采用访谈法、观察和文档收集数据的技术。本研究工具为采访指南、观察表和文件表提供了研究工具。用三角法分析研究数据的技术。这项研究结果,实施健康促进项目(united nations high commissioner for refugees)表示作为发育事件的对策的努力表明,某些方面传递这一信息的沟通和管理对执行者的做这个项目已经执行的善良和真诚,虽然不是罕见的kesalahpaham最大信息传递这一信息的缺乏造成的。项目执行人员还很好地完成了由基础设施支持的任务和足够的项目资金。虽然目前还没有标准的操作程序程序指导方针,但Gladak Pakem Puskesmas作为指导方针,在执行卫生促进活动,以应对特技。这一特技是一个可以实现人类发展的问题。2022年印尼特技表演的发生率将是21.6%。这项研究的目的是描述美国努力促进美国健康促进计划的实施,该计划将在剑兰Pakem健康中心的风险增加。这是研究的性质是共性和描述的。这项研究的信息是公共卫生中心的负责人,也是格兰达帕克健康中心(Gladak Pakem health center)健康推广项目的负责人。数据收集技术使用面试、观察和文档。研究工具是访谈指南,观察表和文件表。研究中使用的技术分析数据是一个技术三角分析。The results of The implementation》这个研究发现那个美国卫生项目景观发育努力to overcome是成功的在好几个aspects, communication and分娩》在内的信息由implementers项目的领导,虽然是音符》misunderstandings to occur帐款来说misinformation不是最高。执行计划还得到了adequate基础设施和funding计划的支持。尽管没有标准操作程序(SOP)来指导该计划的实施,但Gladak Pakem Health Center仍然有技术工具作为指导,以将健康促进作为努力捕获特技。
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引用次数: 0
Relationship between parity and breast cancer risk: A critical review of evidence (with focus on sub-Saharan Africa) 胎次与乳腺癌风险之间的关系:对证据的批判性审查(重点是撒哈拉以南非洲)
IF 0.4 Pub Date : 2023-04-01 DOI: 10.4103/jncd.jncd_6_23
S. Azubuike
The association between parity and breast cancer has been widely investigated in high-income countries. However, in sub-Saharan African (SSA) region, only a few studies have investigated this association. The aim of this study was to critically review the available evidence, highlighting their strength and weakness, thereby providing a basis for more studies in SSA on the topic. A literature search in MEDLINE, Scopus, PubMed, Google Scholar, and reference list of published studies was conducted. Key case control and cohort studies published between 2000 and 2018 were selected for detailed review based on sample size, geographical distributions, and relevance of the findings. Nonanalytical studies were excluded. The findings were summarized using the tables and forest plots based on R Statistical Software version 3.4.0 (2017). This was primarily to provide visual overview of the reviewed studies and not necessarily to provide a pooled estimate. The conclusion was drawn by comparing the number of observed significant findings (assessed based on confidence intervals) with the number of nonsignificant findings across countries and SSA taking into considerations their strengths and weaknesses. Twenty-six case − control studies and 12 cohort studies across the four regions of the world North America, Europe, Asia, and Africa were reviewed. A reduced risk of breast cancer (especially estrogen receptor [ER] positive breast cancer) was observed in most studies, especially studies from high-income countries. While several studies that reported a nonsignificant observation in SSA were limited in sample size, the few that observed a reduced risk of breast with parity among all women were subject to confounding. Nevertheless, recent studies suggest that the role of parity may be modified by ER status and menopausal status. Further investigation of these suggestions will be needed for a clearer understanding of the relationship between parity and breast cancer in SSA.
胎次与乳腺癌之间的关系在高收入国家得到了广泛的调查。然而,在撒哈拉以南非洲(SSA)地区,只有少数研究调查了这种关联。本研究的目的是批判性地回顾现有证据,突出其优势和不足,从而为更多关于该主题的SSA研究提供基础。在MEDLINE、Scopus、PubMed、谷歌Scholar中检索文献,并检索已发表研究的参考文献。根据样本量、地理分布和研究结果的相关性,选择2000年至2018年间发表的关键病例对照和队列研究进行详细审查。非分析性研究被排除在外。使用基于R统计软件3.4.0(2017)版本的表格和森林图对研究结果进行总结。这主要是为了提供所审查研究的直观概述,而不一定是为了提供汇总估计。通过比较各国和SSA中观察到的显著发现的数量(根据置信区间评估)与不显著发现的数量,并考虑到它们的优缺点,得出了结论。我们回顾了北美、欧洲、亚洲和非洲四个地区的26项病例对照研究和12项队列研究。大多数研究,特别是来自高收入国家的研究,都观察到乳腺癌(特别是雌激素受体[ER]阳性乳腺癌)的风险降低。虽然有几项研究报告了SSA的不显著观察结果,但样本量有限,少数观察到所有妇女的乳房产次风险降低的研究受到混淆。然而,最近的研究表明,胎次的作用可能会因ER状态和绝经状态而改变。为了更清楚地了解SSA中胎次与乳腺癌之间的关系,需要对这些建议进行进一步的调查。
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引用次数: 0
Medical emergencies and comorbidities in the elderly and very elderly patients in North India 北印度老年人和高龄患者的医疗紧急情况和合并症
IF 0.4 Pub Date : 2023-04-01 DOI: 10.4103/jncd.jncd_15_23
A. Poddar, Suresh Selvam, A. Saroch, A. Pannu, P. Mathen, Mohan Kumar, D. Dhibar, N. Sharma
Objective: Older patients are rapidly increasing in the emergency department in low-middle-income countries and have poor outcomes. The present study aimed to find the spectrum of comorbidities, medical emergencies, and prognosis in geriatric patients and compare the elderly with very elderly patients in North India. Methodology: A prospective cohort study was conducted on patients aged ≥60 years admitted at Postgraduate Institute of Medical Education and Research, Chandigarh (India). The elderly and very elderly age was defined as 60–74 years and ≥75 years, respectively. Results: Of 935 enrolled patients, 763 (81.6%) were elderly, and 172 (18.4%) were very elderly. Very elderly more frequently required admission in the red area (65.7% vs. 57.4%, P = 0.045). 85.2% (n = 796) of patients had preexisting comorbidities, hypertension (44.5%) and diabetes (34.8%) being the most common. The most comorbidities and the Charlson comorbidity index score distribution were similar to the two age groups; however, hypertension was more in the elderly (52.3% vs. 42.7%, P = 0.022). Overall, gastrointestinal (25.7%), neurological (20.7%), and cardiovascular (19.0%) emergencies were common; however, the very elderly patients more frequently had neurological illnesses (30.8% vs. 18.5%, P < 0.001). Pulmonary infections were the most prevalent infections in both age groups. The frequency of urinary tract infections was higher in the very elderly (17.5% vs. 6.1%, P = 0.023). In-hospital survival was 82.7% (n = 773) and significantly low in the very elderly (76.7% vs. 84.0%, P = 0.023). The survival was predicted by quick sequential organ failure assessment but not by the Charlson comorbidity index. Conclusion: Very elderly patients more frequently have hypertension, neurological emergencies, urinary tract infections, and poor outcomes.
目的:中低收入国家急诊科老年患者数量迅速增加,且预后较差。本研究旨在发现老年患者的合并症、医疗紧急情况和预后,并将老年患者与印度北部的老年患者进行比较。方法:对印度昌迪加尔医学教育与研究研究生院收治的年龄≥60岁的患者进行前瞻性队列研究。老年和极老年年龄分别定义为60-74岁和≥75岁。结果:935例入组患者中,763例(81.6%)为老年人,172例(18.4%)为非常老年人。非常高龄患者在红色区域就诊较多(65.7% vs. 57.4%, P = 0.045)。85.2% (n = 796)的患者既往存在合并症,其中高血压(44.5%)和糖尿病(34.8%)最为常见。两组患者的合并症及Charlson合并症指数得分分布相似;老年人高血压发生率较高(52.3%比42.7%,P = 0.022)。总的来说,胃肠道(25.7%)、神经系统(20.7%)和心血管(19.0%)急症很常见;然而,老年患者更常出现神经系统疾病(30.8%比18.5%,P < 0.001)。肺部感染是两个年龄组中最常见的感染。中老年患者尿路感染发生率较高(17.5%比6.1%,P = 0.023)。住院生存率为82.7% (n = 773),高龄患者的住院生存率较低(76.7% vs. 84.0%, P = 0.023)。通过快速序贯器官衰竭评估来预测生存,而不是通过Charlson合并症指数。结论:高龄患者高血压、神经系统急症、尿路感染发生率高,预后差。
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引用次数: 1
Dietary patterns among chronic kidney disease patients and their impact on their clinical course: A longitudinal study from rural Kanyakumari 慢性肾病患者的饮食模式及其对临床病程的影响:一项来自Kanyakumari农村的纵向研究
IF 0.4 Pub Date : 2023-04-01 DOI: 10.4103/jncd.jncd_48_22
Sundhareshwaran Chandrasekaran, R. Mookambika, Vishnu Ashok, Priya Panicker, G. Nithya
Background: Nonpharmacological management of chronic kidney disease (CKD) by dietary modifications is an integral part in preventing the disease progression into renal failure. Fish has been recommended as a substitute protein instead of meat in renal diets. However, sardines and dried fish which are a staple diet in coastal areas may cause more harm than benefit. Hence, this study was designed to analyze dietary patterns of sardines, dried fish, meat and salt consumption and its impact among CKD patients. Materials and Methods: This longitudinal study was carried out among 100 CKD patients in Nephrology department, excluding seriously ill patients or those on hemodialysis. Dietary patterns were assessed using food frequency questionnaire. Renal parameters and clinical staging were estimated at the beginning of the study and after 2 months. Results: The mean age of the CKD patients was 55.29 years. The mean quantities of sardines, dried fish, meat, and salt consumed per week were 375 g, 70.1 g, 115.7 g, and 39.54 g, respectively. There was a statistically significant increase in the mean values of all renal parameters. Patients who had elevated creatinine and potassium levels had a statistically significant higher mean consumption of sardines and salt, respectively. Conclusion: The consumption of sardines, meat and salt was very high among the CKD patients. Worsening of disease was seen in almost half the study population. Culturally appropriate dietary guidelines are required for diet modifications in CKD patients.
背景:通过饮食调整对慢性肾脏疾病(CKD)进行非药物治疗是预防疾病进展为肾衰竭的一个组成部分。在肾脏饮食中,鱼类被推荐作为替代蛋白质,而不是肉类。然而,沿海地区的主食沙丁鱼和干鱼可能弊大于利。因此,本研究旨在分析CKD患者沙丁鱼、干鱼、肉类和盐的饮食模式及其影响。材料和方法:这项纵向研究在肾病科的100名CKD患者中进行,不包括重病患者或血液透析患者。饮食模式采用食物频率问卷进行评估。在研究开始时和2个月后评估肾脏参数和临床分期。结果:CKD患者的平均年龄为55.29岁。每周消耗的沙丁鱼、干鱼、肉和盐的平均量分别为375克、70.1克、115.7克和39.54克。所有肾脏参数的平均值均有统计学意义的增加。肌酸酐和钾水平升高的患者对沙丁鱼和盐的平均摄入量分别具有统计学意义。结论:CKD患者对沙丁鱼、肉和盐的摄入量较高。在几乎一半的研究人群中发现疾病恶化。CKD患者的饮食调整需要符合文化的饮食指南。
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引用次数: 0
Is dual bronchodilator therapy the new GOLD standard for initiating treatment for chronic obstructive pulmonary disease? 双支气管扩张剂治疗是开始治疗慢性阻塞性肺病的新GOLD标准吗?
IF 0.4 Pub Date : 2023-04-01 DOI: 10.4103/jncd.jncd_58_23
A. Aggarwal
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引用次数: 0
期刊
International Journal of Noncommunicable Diseases
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