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Is dual bronchodilator therapy the new GOLD standard for initiating treatment for chronic obstructive pulmonary disease? 双支气管扩张剂治疗是开始治疗慢性阻塞性肺病的新GOLD标准吗?
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-04-01 DOI: 10.4103/jncd.jncd_58_23
A. Aggarwal
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引用次数: 0
Pretransplant hemodialysis: Lived experiences 移植前血液透析:生活经验
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-04-01 DOI: 10.4103/jncd.jncd_34_23
Priya, D. Kenwar, M. Dutta
Introduction: End-stage renal disease (ESRD) is a rapidly increasing global health problem where the kidney damage is irreversible. Worldwide, hemodialysis is the most common kidney replacement therapy which increases longevity but is not the ultimate cure, and at the same time, there are multiple complications associated with this treatment modality making life miserable for these patients. Plenty of literature is available on patient education, side effects, and complications of hemodialysis, but very few attempts have been made to understand patients' experiences living on dialysis. Materials and Methods: A phenomenological research design was adopted to explore lived experiences of patients on hemodialysis. Using purposive sampling technique, adult (60 years) posttransplant patients who had hemodialysis at least for 6 months during pretransplantation phase were enrolled. Data were collected through semi-structured interviews, analyzed using descriptive statistics for quantitative and Colaizzi's method for qualitative data. Results: The most common medical diagnosis was unknown chronic glomerulonephritis, and the prevalent comorbid condition was hypertension. Based on participants' verbatim, total 5 themes and 13 subthemes were extracted after data analysis. The main themes emerged were disease- and dialysis-associated problems, emotional turmoil, financial burden, social isolation, and changes in lifestyle. Conclusion: The present study concluded that ESRD patients on haemodialysis experienced physiological disturbances, emotional distress and financial burden. Social isolation, financial constraints, and changes in lifestyle were major challenges faced by patients. Professionals need empathic attitude to deal with patients on hemodialysis to minimize their sufferings.
终末期肾病(ESRD)是一个快速增长的全球性健康问题,其中肾脏损害是不可逆转的。在世界范围内,血液透析是最常见的肾脏替代疗法,它可以延长寿命,但不是最终的治愈方法,同时,这种治疗方式有多种并发症,使这些患者的生活变得痛苦。关于患者教育、副作用和血液透析并发症的文献很多,但很少有人尝试了解透析患者的生活经历。材料与方法:采用现象学研究设计,探讨血液透析患者的生活体验。采用有目的的抽样技术,纳入了在移植前阶段进行血液透析至少6个月的成人(60岁)移植后患者。数据通过半结构化访谈收集,定量数据采用描述性统计,定性数据采用Colaizzi方法进行分析。结果:内科诊断以不明原因慢性肾小球肾炎最为常见,常见的合并症为高血压。根据被试的逐字记录,经过数据分析,共提取出5个主题和13个副主题。出现的主要主题是与疾病和透析相关的问题、情绪动荡、经济负担、社会孤立和生活方式的变化。结论:经血液透析治疗的ESRD患者存在生理障碍、情绪困扰和经济负担。社会孤立、经济拮据和生活方式改变是患者面临的主要挑战。专业人员需要以共情的态度对待血液透析患者,以尽量减少他们的痛苦。
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引用次数: 0
Effectiveness of educational interventions on knowledge and behavioral practices of adolescents for prevention of noncommunicable diseases in low- and middle-income countries: A systematic review protocol 低收入和中等收入国家青少年预防非传染性疾病知识和行为实践教育干预的有效性:一项系统审查方案
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-04-01 DOI: 10.4103/jncd.jncd_20_23
Sugandha Jauhari, Pratyaksha Pandit, M. Agarwal, P. Bajpai, Abhishek Singh, D. James
Introduction: The rising burden of noncommunicable diseases (NCDs) is a dominating public health crisis, globally causing 38 million of 57 million deaths annually, with 85% of these deaths occurring in low- and middle-income countries (LMICs). However, while addressing NCDs, adolescents have been largely overlooked, who have a notable share in the NCD burden globally. Adolescents are vulnerable for developing high-risk behaviors, which puts them at high risk of NCDs such as ischemic heart diseases, diabetes, and stroke. Objective: The objective of this systematic review will be to identify the effectiveness of educational interventions on the knowledge and behavioral practices of adolescents for the prevention of NCDs in LMICs. Methodology: Five electronic databases such as PubMed, the Cochrane Central Register of Controlled Trials, Google Scholar, Embase, and Scopus will be utilized for generating pooled evidence. Two reviewers will individually screen the titles and abstracts for eligibility, and in case of any disagreement, the help of a third reviewer will be taken. Recognized studies will be critically appraised for methodological quality using the Cochrane risk-of-bias tool. Data will be extracted from the studies included in the review for author's name, year of study, study setting, study design, study participants and their age, sample size in the intervention group, NCD domain covered by the study intervention, intervention details, measure of outcome, etc. For data synthesis, studies will be pooled using RevMan software and effect sizes will be depicted using forest plots. The Grading of Recommendations, Assessment, Development, and Evaluation approach to grade the certainty of evidence will be followed for assessing the quality of evidence. Publication bias will also be checked using funnel plots and Egger's test. Clinical Relevance: To the best of our knowledge, this will be the first systematic review that will assess the empirical evidence and evaluate the effectiveness of educational interventions for the prevention of NCDs among adolescents of LMICs. This review will assist the public health experts and policymakers in designing effective intervention for preventing NCDs among adolescents. Results and Conclusion: The results of this systematic review will provide an in-depth insight of the existing country-specific educational policies and interventions for the prevention of NCDs among adolescents in various LMICs. This will help in the replication of such cost-effective educational models or interventions in other LMICs followed by advocacy in their school policy reforms and other related programs focusing on NCDs.
非传染性疾病(ncd)负担的不断上升是一项主要的公共卫生危机,每年在全球5700万人死亡中造成3800万人死亡,其中85%发生在低收入和中等收入国家。然而,在应对非传染性疾病的同时,青少年在很大程度上被忽视了,他们在全球非传染性疾病负担中占有显著份额。青少年很容易养成高风险行为,这使他们面临罹患缺血性心脏病、糖尿病和中风等非传染性疾病的高风险。目的:本系统综述的目的是确定教育干预对中低收入国家青少年预防非传染性疾病的知识和行为实践的有效性。方法:5个电子数据库,如PubMed, Cochrane Central Register of Controlled Trials,谷歌Scholar, Embase和Scopus将被用于生成汇总证据。两位审稿人将分别对标题和摘要进行筛选,如有异议,将接受第三位审稿人的帮助。认可的研究将使用Cochrane风险偏倚工具对方法学质量进行严格评价。数据将从纳入综述的研究中提取,包括作者姓名、研究年份、研究设置、研究设计、研究参与者及其年龄、干预组样本量、研究干预所涵盖的非传染性疾病领域、干预细节、结果测量等。在数据合成方面,研究将使用RevMan软件汇总,效应大小将使用森林图来描述。对证据的确定性进行分级的建议、评估、发展和评价方法将被用于评估证据的质量。发表偏倚也将使用漏斗图和Egger检验进行检查。临床相关性:据我们所知,这将是评估经验证据和评估教育干预措施在中低收入国家青少年中预防非传染性疾病有效性的第一个系统综述。本综述将有助于公共卫生专家和决策者设计有效的干预措施,预防青少年非传染性疾病。结果和结论:本系统综述的结果将深入了解不同中低收入国家预防青少年非传染性疾病的现有国家具体教育政策和干预措施。这将有助于在其他中低收入国家复制这种具有成本效益的教育模式或干预措施,然后在其学校政策改革和其他以非传染性疾病为重点的相关方案中进行宣传。
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引用次数: 0
The prevalence of metabolic syndrome and its components among South Indian Chenchu tribal adults 南印度陈楚部落成年人代谢综合征的患病率及其组成部分
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-04-01 DOI: 10.4103/jncd.jncd_38_23
C. Luc, Kara Herrera, R. Allam, Sabitha Gandhamalla, Ramkishan Dharmakari, M. Dinaker, V. Yeldandi
Background: Dietary patterns are paramount in the prevention and management of metabolic syndrome (MetS) yet the definition and criteria for MetS diagnosis varies. This analysis aims to estimate the prevalence of MetS among the adult Chenchu tribal population comparing International Diabetes Federation (IDF) and Adult Treatment Panel (ATP) definitions of MetS and assess the relationship between dietary patterns and MetS. Materials and Methods: Demographics, medical history, nutrition, and physical activity were collected among 337 South Indian Chenchu tribal adults. The prevalence ratios and 95% confidence intervals of MetS using ATP and IDF definitions were estimated and associations between individual components of the MetS definitions, demographics, and dietary patterns were assessed. Pearson correlation coefficients (r) were calculated between the Modified Finnish Diabetic Risk Score (FINDRISC)-Bahasa Indonesia instrument and MetS definitions. Results: The prevalence of MetS was low by IDF (25, 7.4%) and ATP (22, 6.5%) definitions, while reporting vigorous physical activity (202, 59.9%) and a “vegetarian” dietary pattern (173, 51.3%) were high. Increasing age, high mutton consumption, and “empty-calorie” dietary pattern were associated with an increased prevalence of MetS, while vigorous physical activity and “vegetarian” dietary pattern were protective of MetS. The modified FINDRISC was not highly correlated with IDF MetS (r = 0.47; P < 0.0001) or ATP MetS (r = 0.11; P = 0.0683). Conclusions: Healthy behaviors, such as vigorous physical activity and high vegetable consumption, may contribute to the low prevalence of MetS in Chenchu tribal adults. Future efforts should continue to monitor dietary patterns and the prevalence of MetS in the understudied South Indian Chenchu tribal population.
背景:饮食模式在代谢综合征(MetS)的预防和管理中至关重要,但代谢综合征诊断的定义和标准各不相同。本分析旨在通过比较国际糖尿病联合会(IDF)和成人治疗小组(ATP)对MetS的定义,估计成年陈楚部落人群中MetS的患病率,并评估饮食模式与MetS之间的关系。材料和方法:收集337名南印度陈楚部落成年人的人口学、病史、营养和体力活动。使用ATP和IDF定义估计MetS的患病率和95%置信区间,并评估MetS定义的各个组成部分、人口统计和饮食模式之间的相关性。计算改良芬兰糖尿病风险评分(FINDRISC)-Bahasa Indonesia工具和MetS定义之间的Pearson相关系数(r)。结果:根据IDF(25.7.4%)和ATP(22.6.5%)的定义,代谢综合征的患病率较低,而报告的剧烈体育活动(20259.9%)和“素食”饮食模式(17351.3%)较高。年龄增长、高羊肉消费量和“空热量”饮食模式与代谢综合征患病率增加有关,而剧烈的体育活动和“素食”饮食模式对代谢综合征有保护作用。改良FINDRISC与IDF-MetS(r=0.47;P<0.0001)或ATP MetS(r=0.11;P=0.0683)无高度相关性。未来的工作应该继续监测饮食模式和MetS在研究不足的南印度陈楚部落人口中的流行情况。
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引用次数: 0
Noncommunicable diseases among tribal populations in India: A case of double jeopardy 印度部落人口中的非传染性疾病:双重危险的案例
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-01-01 DOI: 10.4103/jncd.jncd_24_23
Natasha Dawa, J. Narain
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引用次数: 0
Economic burden of road traffic injuries among hospitalized subjects in a tertiary care center in Bengaluru, India: A cost of illness study 印度班加罗尔三级医疗中心住院受试者的道路交通伤害经济负担:疾病成本研究
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-01-01 DOI: 10.4103/jncd.jncd_61_22
R. Kumar, F. Fathima, Twinkle Agrawal, D. Misquith, G. Gururaj
Background: Road traffic injuries (RTIs) are the major causes of mortality, morbidity, and disability among young adults and pose a significant economic burden to individuals, families, and communities. Objective: To estimate the cost of care at discharge, 3 months and 6 months among patients with RTIs admitted to a private tertiary hospital in Bengaluru, India. Methods: A cost-of-illness study from patient's perspective was done among 150 hospitalized injured subjects with RTIs admitted to a tertiary care hospital in Bengaluru city. A face validated, structured interview schedule was administered in local language at baseline (hospital discharge time), 1 month and at 6 months to capture data on direct medical costs, direct nonmedical costs, and indirect costs incurred by the RTI victims and their family members. Hospital bills were reviewed for all the patients included in the study. Results: Among the 150 study participants, majority were men (94.67%), with a mean age of 35.36 years ± 14.62 years and majority were two-wheeler riders/pillions and pedestrians. Our results show the median cost incurred for care of RTI to be INR 106,374 (inter quartile range [IQR] 57,402–163,250) (USD 1418 [IQR 765–2176]). Direct medical costs contributed to 66% of the costs, whereas direct nonmedical and indirect costs contributed to 21% and 13% of the total costs, respectively. Conclusion: RTIs contribute to significant economic burden to patients. While prevention should be our primary goal, health financing and risk protection mechanisms should be strengthened by streamlining insurance coverage mechanisms to reduce out-of-pocket expenditure.
背景:道路交通伤害(RTI)是年轻人死亡、发病和残疾的主要原因,对个人、家庭和社区构成了重大经济负担。目的:评估印度班加罗尔一家私立三级医院RTI患者出院时、3个月和6个月的护理费用。方法:从患者的角度对班加罗尔市一家三级护理医院收治的150名RTI住院受伤受试者进行疾病成本研究。在基线(出院时间)、1个月和6个月时,用当地语言进行人脸验证的结构化访谈,以获取RTI受害者及其家人产生的直接医疗费用、直接非医疗费用和间接费用的数据。对纳入研究的所有患者的医院账单进行了审查。结果:在150名研究参与者中,大多数是男性(94.67%),平均年龄为35.36岁±14.62岁,大多数是两轮车乘客/后座和行人。我们的研究结果显示,RTI的护理费用中位数为106374印度卢比(四分位数区间[IQR]57402–163250)(1418美元[IQR765–2176])。直接医疗费用占总费用的66%,而直接非医疗费用和间接费用分别占总成本的21%和13%。结论:RTI给患者带来了巨大的经济负担。虽然预防应该是我们的首要目标,但应该通过简化保险覆盖机制来加强医疗融资和风险保护机制,以减少自付支出。
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引用次数: 0
Acute sarcopenia and risk of new-onset diabetes in coronavirus disease 2019 patients 2019冠状病毒病患者急性肌肉减少症与新发糖尿病风险
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-01-01 DOI: 10.4103/jncd.jncd_17_23
T. Sathish
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引用次数: 0
Cervical cancer care cascade among women living with human immunodeficiency virus in 13 sub-Saharan Africa countries between 2019 and 2021: An ecological analysis of PEPFAR Panorama cervical cancer program data 2019年至2021年,13个撒哈拉以南非洲国家感染人类免疫缺陷病毒的妇女的癌症治疗级联:PEPFAR Panorama癌症宫颈癌项目数据的生态分析
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-01-01 DOI: 10.4103/jncd.jncd_14_23
W. Ng'ambi, Cosmas Zyambo
Introduction: Cervical cancer (CC) is the fourth main cause of death among women. Poor uptake of CC screening has indirect effects on increased mortality among women. Therefore, we employed the care cascade to understand the CC outcomes in sub-Saharan Africa (SSA) using the PEPFAR Panorama CC data collected between 2019 and 2021. Methods: A retrospective study using the PEPFAR Panorama CC data, from 13 countries from SSA, was performed. We calculated the proportions of women who were screened, those who were found to have positive results after screening for CC, and those who were linked to CC treatment. Results: A total of 2,312,541 were eligible for screening and of these, 1,429,925 (62%) were screened for CC. Of these, 162,758 (11%) were diagnosed with CC. Of these, 115,890 (71%) were provided with treatment. CC screening increased from 41% in 2019 to 90% in 2021. The CC diagnosis ranged from 8% in 2019 to 13% in 2021. CC treatment coverage increased from 64% in 2019 to 75% in 2021. Screening uptake, CC diagnosis, and CC treatment coverage varied by country and age of the women. Conclusion: There were variations in CC screening and treatment uptake for CC by country and age. With these inequalities in screening and coverage of treatment for CC, eliminating CC as stipulated in the sustainable development goals will remain a farfetched dream.
简介:癌症是女性死亡的第四大主要原因。CC筛查效果不佳对妇女死亡率增加有间接影响。因此,我们使用2019年至2021年间收集的PEPFAR Panorama CC数据,采用护理级联来了解撒哈拉以南非洲(SSA)的CC结果。方法:使用来自SSA 13个国家的PEPFAR Panorama CC数据进行回顾性研究。我们计算了接受筛查的女性、CC筛查后结果呈阳性的女性以及与CC治疗相关的女性的比例。结果:共有2312541人符合筛查条件,其中1429925人(62%)接受了CC筛查。其中162758人(11%)被诊断为CC。其中115890人(71%)接受了治疗。CC筛查从2019年的41%增加到2021年的90%。CC的诊断率从2019年的8%到2021年的13%不等。CC治疗覆盖率从2019年的64%增加到2021年的75%。筛查接受率、CC诊断和CC治疗覆盖率因国家和女性年龄而异。结论:CC的筛查和治疗效果因国家和年龄而异。由于CC的筛查和治疗覆盖率存在这些不平等,按照可持续发展目标的规定消除CC仍然是一个遥不可及的梦想。
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引用次数: 0
The world noncommunicable disease federation's international certification course of primary health-care physician in noncommunicable diseases: Key to strengthen primary health-care interventions in noncommunicable diseases 世界非传染性疾病联合会非传染性疾病初级保健医师国际认证课程:加强非传染性疾病初级保健干预措施的关键
Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-01-01 DOI: 10.4103/jncd.jncd_90_23
JS Thakur, Ronika Paika
Noncommunicable diseases (NCDs) have become a major global problem, accounting for approximately three-fifths of morbidity and mortality. Due to the epidemiological shift, the disease pattern in many developing nations is shifting from infectious to chronic NCDs.[1] NCDs cause 41 million deaths every year, accounting for 80.2% of all deaths worldwide. There are over 15 million (38%) premature NCD mortality that is avoidable and preventable. Around 77% of all NCD deaths occur in low-middle-income countries (LMICs).[2] Primary health care (PHC) is essential for achieving universal health coverage and reducing the prevalence of NCDs. However, there is a huge capacity gap, and the majority of primary care physicians are not competent to diagnose and treat NCDs, especially in LMICs.[3] A well-functioning primary care system, including ambulatory primary care administered through primary health centers, is cost-effective and can meet up to 90% of health-care demand in poor and middle-income countries, including NCDs.[4] Primary care is more than just a first point of contact; it is the base of a health-care system. It is available to all patients and can manage NCDs in their early stages by providing first contact, continuity, and integration of care. According to the World NCD Federation guidelines for NCDs in PHC settings and the WHO package of essential noncommunicable Package, high-impact important NCD interventions can be offered through PHC to improve early detection and treatment. Approximately 80% of disease conditions, according to estimates, can be handled at the primary care level with a primary care physician and a community health worker.[5] Almost 52% of all conditions, especially NCDs, can be managed at the primary care level.[6] The phrase “gatekeeping” refers to the role of primary care physicians or general practitioners in improving access, which has a significant impact on service utilization, health outcomes, health-care expenditures, and patient satisfaction. There is a lack of effective implementation of NCD services at the PHC level, due to a lack of trained health workforce and essential supplies for implementing comprehensive NCD care programs (standards of treatment protocols, referral, and follow-up for NCDs).[7] To address this huge capacity gap of PHC professionals, the World NCD Federation has initiated an International Course as “Certification of PHC physician in NCDs” which focuses on meeting the requirements of the Global NCD Agenda under the Global strategy for prevention and control of NCDs.[8] The World NCD Federation aimed to develop this e-learning course to provide simple and comprehensive guidance on the prevention, surveillance, and management of common NCDs to health-care professionals, including frontline workers, community health workers, and PHC doctors. The objective of the course includes the development and implementation of a certification course for primary health physicians in NCDs at the global level
非传染性疾病(NCDs)已成为一个主要的全球问题,约占发病率和死亡率的五分之三。由于流行病学的转变,许多发展中国家的疾病模式正在从传染性非传染性疾病转变为慢性非传染性疾病非传染性疾病每年造成4100万人死亡,占全世界死亡总数的80.2%。有超过1500万(38%)非传染性疾病过早死亡是可以避免和预防的。约77%的非传染性疾病死亡发生在中低收入国家初级卫生保健对于实现全民健康覆盖和减少非传染性疾病的流行至关重要。然而,存在巨大的能力缺口,大多数初级保健医生没有能力诊断和治疗非传染性疾病,特别是在中低收入国家一个运作良好的初级保健系统,包括通过初级卫生中心管理的流动初级保健,具有成本效益,可以满足贫穷和中等收入国家(包括非传染性疾病国家)高达90%的卫生保健需求初级保健不仅仅是第一个接触点;它是卫生保健系统的基础。它面向所有患者,并可通过提供初次接触、连续性和综合护理,在非传染性疾病的早期阶段进行管理。根据世界非传染性疾病联合会关于初级保健环境中非传染性疾病的指南和世卫组织基本非传染性一揽子措施,可以通过初级保健提供高影响的重要非传染性疾病干预措施,以改善早期发现和治疗。据估计,大约80%的疾病可以在初级保健一级由初级保健医生和社区卫生工作者处理几乎52%的疾病,特别是非传染性疾病,可以在初级保健一级得到控制"把关"一词是指初级保健医生或全科医生在改善可及性方面的作用,这对服务的利用、健康结果、保健支出和患者满意度有重大影响。由于缺乏训练有素的卫生人员和实施综合非传染性疾病护理方案(治疗方案标准、转诊和非传染性疾病后续治疗)所需的基本用品,初级保健一级缺乏有效实施非传染性疾病服务为了解决初级保健专业人员的这一巨大能力差距,世界非传染性疾病联合会启动了一门国际课程,名为“非传染性疾病初级保健医生认证”,重点是满足预防和控制非传染性疾病全球战略下的全球非传染性疾病议程的要求世界非传染性疾病联合会旨在开发这一电子学习课程,为包括一线工作者、社区卫生工作者和初级保健医生在内的卫生保健专业人员提供关于预防、监测和管理常见非传染性疾病的简单而全面的指导。该课程的目标包括为全球一级的初级保健医生制定和实施非传染性疾病认证课程,以及初级保健医生的能力建设,以了解和掌握主要非传染性疾病的技能。课程结构包括电子学习计划,包括12周的核心模块和3-4天的联系计划。核心模块将侧重于非传染性疾病的基础知识;健康促进和健康与福祉,包括综合办法、非传染性疾病的社会经济影响和卫生系统办法;非传染性疾病监测;非传染性疾病管理和标准治疗指南;制定和有效实施国家非传染性疾病规划和非传染性疾病多部门行动计划;非传染性疾病的姑息治疗和医疗紧急情况;设施一级/初级保健一级的全球监测框架和评价;以及临床决策支持系统与家庭医学的作用。联络计划包括技能发展,包括使用主要非传染性疾病的风险预测分数;非传染性疾病风险因素数据的收集和测量;血压监测和血糖仪使用情况;人体测量(身高、体重、体质指数、腰围、皮肤褶皱厚度);诊断非传染性疾病所需的调查;生化测量和解释;心电读数和解读;宫颈癌目视检查、口腔检查、临床/自乳检查。世界非传染性疾病联合会还发布了由几个国家和国际组织的专家制定的基于证据的非传染性疾病业务指南。该指南详细介绍了初级保健机构预防非传染性疾病、监测和管理9种非传染性疾病的政策和非政策方法。这些指南将成为各级卫生保健的执业医生和社区卫生专业人员提供有效的非传染性疾病预防和护理的关键基础工具。 [9]培训将得到认可,并将确保达到非传染性疾病目标和指标以及2030年可持续发展目标(sdg)所需的标准,这些目标旨在由各国实现。课程的注册是开放的,可以在网上(https://www.worldncdfederation.org/international-certification/)完成,也有一些全额奖学金。预计这门课程将有助于中低收入国家部分住院项目的能力建设、国家非传染性疾病规划的有效实施以及可持续发展目标的实现。
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引用次数: 0
Prevalence of resistant hypertension and its relation with plasma lipoprotein-associated phospholipase A2 顽固性高血压患病率及其与血浆脂蛋白相关磷脂酶A2的关系
IF 0.4 Q4 MEDICINE, GENERAL & INTERNAL Pub Date : 2023-01-01 DOI: 10.4103/jncd.jncd_80_22
Sriharsha Boppana, Nikhil Ravula, L. S. Simhachalam Kutikuppala, Nagarjuna Sivaraj, C. Raja Hamsa, Sidharth Mahajan, P. Chaitanya
Background: A major modifiable risk factor for cardiovascular disease is hypertension. Resistant hypertension is observed to be associated with an increased likelihood of deleterious effects such as cardiovascular events, cerebrovascular accident, and renal dysfunction. The raised levels of inflammatory cytokines in the plasma like the C-reactive protein (CRP) have previously been observed to be significantly raised in hypertensive patients, but the overlying mechanisms corresponding to these processes remain unknown. Materials and Methods: In essence, this was an observational study with data collected from a population at a specific moment in the time to assess the relationships between the variables analyzed. A total of 200 individuals with arterial hypertension took part in the study. Fasting venous blood was obtained to evaluate plasma lipoprotein-related phospholipase A2 (Lp-PLA2) activity, and baseline data were collected. To diagnose RH, a 24-h ambulatory blood pressure management was done. Results: RH was observed among 100 patients and found to be predominant among males and older individuals, who were smokers and having hypertension for a longer period of time with higher Lp-PLA2 activity. More RH patients used calcium channel blockers and diuretics, while a fewer used angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and statins (P 0.05 for all comparisons). Conclusion: The plasma Lp-PLA2 activity beyond a certain threshold suggests a raised risk of RH, and the statins can help in reducing the RH incidence among persons with high Lp-PLA2 levels.
背景:心血管疾病的一个主要可改变的危险因素是高血压。据观察,顽固性高血压与心血管事件、脑血管意外和肾功能障碍等有害影响的可能性增加有关。血浆中炎性细胞因子水平升高,如C反应蛋白(CRP),先前已观察到在高血压患者中显著升高,但与这些过程相对应的叠加机制尚不清楚。材料和方法:本质上,这是一项观察性研究,使用在特定时刻从人群中收集的数据来评估所分析变量之间的关系。共有200名动脉高压患者参与了这项研究。采集禁食静脉血以评估血浆脂蛋白相关磷脂酶A2(Lp-PLA2)活性,并收集基线数据。为了诊断RH,进行了24小时动态血压管理。结果:在100名患者中观察到RH,发现RH在男性和老年人中占主导地位,他们是吸烟者,高血压持续时间较长,Lp-PLA2活性较高。使用钙通道阻滞剂和利尿剂的RH患者较多,而使用血管紧张素转换酶抑制剂、血管紧张素受体阻滞剂和他汀类药物的患者较少(所有比较均为0.05)。结论:血浆Lp-PLA2活性超过一定阈值表明RH风险增加,他汀类药物有助于降低Lp-PLA2-高水平人群的RH发生率。
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International Journal of Noncommunicable Diseases
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