首页 > 最新文献

Medicina de Familia-SEMERGEN最新文献

英文 中文
Uso de la ecografía clínica en atención primaria: marcadores de congestión en la insuficiencia cardiaca congestiva 临床超声在初级保健中的应用:充血性心力衰竭中的充血性标志
IF 0.9 Q4 PRIMARY HEALTH CARE Pub Date : 2024-12-01 DOI: 10.1016/j.semerg.2024.102383
C. Montero Peña , F.J. Palma Maldonado , J. Fidalgo López , C. Casanova García
The patient with heart failure (HF) is a frequent scenario in primary care consultations. The presence of subclinical congestion is a predictor of rehospitalization and adverse events in these patients. The assessment of congestion is complex due to the low sensitivity of classic symptoms and signs, which leads to underdiagnosis, delayed initiation of treatment and a greater likelihood of complications. The family doctor should be familiar with new techniques for congestion assessment, such as the study of venous congestion with ultrasound and pulmonary ultrasound. This makes it possible to know the existence of subclinical congestion in a more realistic way. Clinical ultrasound in the hands of the family doctor individualizes decongestive therapy in patients with HF in an accurate, fast and safe way.
心力衰竭(HF)患者是一个常见的情况,在初级保健咨询。亚临床充血的存在是这些患者再次住院和不良事件的预测因子。由于对典型症状和体征的敏感性较低,充血的评估很复杂,这导致诊断不足、延迟开始治疗和更可能出现并发症。家庭医生应熟悉新的充血评估技术,如研究静脉充血超声和肺超声。这使得以更现实的方式了解亚临床充血的存在成为可能。家庭医生手中的临床超声为心衰患者提供了准确、快速、安全的个体化降血治疗。
{"title":"Uso de la ecografía clínica en atención primaria: marcadores de congestión en la insuficiencia cardiaca congestiva","authors":"C. Montero Peña ,&nbsp;F.J. Palma Maldonado ,&nbsp;J. Fidalgo López ,&nbsp;C. Casanova García","doi":"10.1016/j.semerg.2024.102383","DOIUrl":"10.1016/j.semerg.2024.102383","url":null,"abstract":"<div><div>The patient with heart failure (HF) is a frequent scenario in primary care consultations. The presence of subclinical congestion is a predictor of rehospitalization and adverse events in these patients. The assessment of congestion is complex due to the low sensitivity of classic symptoms and signs, which leads to underdiagnosis, delayed initiation of treatment and a greater likelihood of complications. The family doctor should be familiar with new techniques for congestion assessment, such as the study of venous congestion with ultrasound and pulmonary ultrasound. This makes it possible to know the existence of subclinical congestion in a more realistic way. Clinical ultrasound in the hands of the family doctor individualizes decongestive therapy in patients with HF in an accurate, fast and safe way.</div></div>","PeriodicalId":53212,"journal":{"name":"Medicina de Familia-SEMERGEN","volume":"50 9","pages":"Article 102383"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142745382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uso de la ecografía clínica en atención primaria: hematuria 临床超声在初级保健中的应用:血肿
IF 0.9 Q4 PRIMARY HEALTH CARE Pub Date : 2024-12-01 DOI: 10.1016/j.semerg.2024.102382
A. Segura Grau , C.A. Soto Castro , A.M. Sánchez Sempere , M. Mejías Gil
Hematuria is a frequent entity in primary care. The differential diagnosis covers multiple causes: physiological, pharmacological, false hematuria and urological pathologies, being fundamental in its study to assess the possible malignant neoplastic causes.
Urologic ultrasound is a non-invasive technique, using a 3.5-5 MHz concave probe, with the patient lying supine and the bladder full. After anamnesis, physical examination, study of urinarium sediment and laboratory analysis to determine renal function, ultrasound allows the family doctor to confirm or rule out a large number of processes related to the etiology of hematuria: cysts and kidney masses, renal lithiasis, nephrocalcinosis, benign prostatic hyperplasia, polyps or vesical masses... However, this alone is not sufficient to establish a firm diagnosis in all cases.
Currently, there is no general consensus about the most appropriate diagnostic sequence in the study of hematuria, and several clinical guidelines were chosen for the application of different strategies depending on the risk factors. However, ultrasound together with cystoscopy has been positioned as the most cost-effective diagnostic strategy in most cases.
The use of ultrasound in the evaluation of the patient with hematuria in primary care allows a valuable diagnostic approach to be made, detecting warning signs and properly orienting the patient's referral to other levels, if necessary, early.
血尿是初级保健中常见的疾病。鉴别诊断包括多种原因:生理、药理学、假血尿和泌尿病理学,是评估可能的恶性肿瘤病因的基础。泌尿系统超声是一种无创技术,使用3.5-5 MHz凹探头,患者仰卧,膀胱充满。经过记忆、体格检查、尿液沉淀物研究和实验室分析确定肾功能后,超声可以让家庭医生确认或排除大量与血尿病因相关的过程:囊肿和肾肿块、肾结石、肾钙质沉着症、良性前列腺增生、息肉或膀胱肿块……然而,仅凭这一点并不足以在所有病例中建立确定的诊断。目前,对于血尿研究中最合适的诊断顺序并没有普遍的共识,根据不同的危险因素选择了几种临床指南来应用不同的策略。然而,在大多数情况下,超声联合膀胱镜检查已被定位为最具成本效益的诊断策略。在初级保健中,使用超声对血尿患者进行评估,可以做出有价值的诊断方法,发现警告信号,并在必要时尽早适当地指导患者转诊到其他级别。
{"title":"Uso de la ecografía clínica en atención primaria: hematuria","authors":"A. Segura Grau ,&nbsp;C.A. Soto Castro ,&nbsp;A.M. Sánchez Sempere ,&nbsp;M. Mejías Gil","doi":"10.1016/j.semerg.2024.102382","DOIUrl":"10.1016/j.semerg.2024.102382","url":null,"abstract":"<div><div>Hematuria is a frequent entity in primary care. The differential diagnosis covers multiple causes: physiological, pharmacological, false hematuria and urological pathologies, being fundamental in its study to assess the possible malignant neoplastic causes.</div><div>Urologic ultrasound is a non-invasive technique, using a 3.5-5<!--> <!-->MHz concave probe, with the patient lying supine and the bladder full. After anamnesis, physical examination, study of urinarium sediment and laboratory analysis to determine renal function, ultrasound allows the family doctor to confirm or rule out a large number of processes related to the etiology of hematuria: cysts and kidney masses, renal lithiasis, nephrocalcinosis, benign prostatic hyperplasia, polyps or vesical masses... However, this alone is not sufficient to establish a firm diagnosis in all cases.</div><div>Currently, there is no general consensus about the most appropriate diagnostic sequence in the study of hematuria, and several clinical guidelines were chosen for the application of different strategies depending on the risk factors. However, ultrasound together with cystoscopy has been positioned as the most cost-effective diagnostic strategy in most cases.</div><div>The use of ultrasound in the evaluation of the patient with hematuria in primary care allows a valuable diagnostic approach to be made, detecting warning signs and properly orienting the patient's referral to other levels, if necessary, early.</div></div>","PeriodicalId":53212,"journal":{"name":"Medicina de Familia-SEMERGEN","volume":"50 9","pages":"Article 102382"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142757720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uso de la ecografía clínica en atención primaria: riesgo cardiovascular 临床超声在初级保健中的应用:心血管风险
IF 0.9 Q4 PRIMARY HEALTH CARE Pub Date : 2024-12-01 DOI: 10.1016/j.semerg.2024.102387
M. Román Garrido , I. Salcedo Joven , C. Montero-Peña , P. Madrigal Laguía
From primary care we work on the prevention and treatment of cardiovascular risk in our patients. The physical examination, the electrocardiogram and the analysis are the classic parameters and continue being the most efficient way to estimate the presence and control of cardiovascular factors and target organ damage, to optimize the cardiovascular risk stratification. The use of ultrasound by the primary care doctor to complete the clinical information is a reality that helps to strengthen the diagnostic suspicion, monitorize the clinical evolution and even decide the best therapeutic plan. This work proposes to establish the bases for the use of ultrasound for the diagnosis of carotid/femoral atheromatosis, the use of echocardioscopy, screening for abdominal aortic aneurysm, the assessment of hepatic steatosis and the study of the kidney in patients with chronic kidney disease.
在初级保健方面,我们致力于预防和治疗患者的心血管风险。体格检查、心电图和分析是经典参数,仍然是评估心血管因素和靶器官损害存在和控制、优化心血管危险分层的最有效方法。初级保健医生利用超声完成临床信息是一种现实,有助于加强诊断怀疑,监测临床进展,甚至决定最佳治疗方案。本工作拟为超声在颈动脉/股动脉粥样硬化诊断、超声心动图应用、腹主动脉瘤筛查、肝脂肪变性评估及慢性肾病患者肾脏研究中的应用奠定基础。
{"title":"Uso de la ecografía clínica en atención primaria: riesgo cardiovascular","authors":"M. Román Garrido ,&nbsp;I. Salcedo Joven ,&nbsp;C. Montero-Peña ,&nbsp;P. Madrigal Laguía","doi":"10.1016/j.semerg.2024.102387","DOIUrl":"10.1016/j.semerg.2024.102387","url":null,"abstract":"<div><div>From primary care we work on the prevention and treatment of cardiovascular risk in our patients. The physical examination, the electrocardiogram and the analysis are the classic parameters and continue being the most efficient way to estimate the presence and control of cardiovascular factors and target organ damage, to optimize the cardiovascular risk stratification. The use of ultrasound by the primary care doctor to complete the clinical information is a reality that helps to strengthen the diagnostic suspicion, monitorize the clinical evolution and even decide the best therapeutic plan. This work proposes to establish the bases for the use of ultrasound for the diagnosis of carotid/femoral atheromatosis, the use of echocardioscopy, screening for abdominal aortic aneurysm, the assessment of hepatic steatosis and the study of the kidney in patients with chronic kidney disease.</div></div>","PeriodicalId":53212,"journal":{"name":"Medicina de Familia-SEMERGEN","volume":"50 9","pages":"Article 102387"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142745379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uso de la ecografía clínica en atención primaria: adenopatías 临床超声在初级保健中的应用:腺病
IF 0.9 Q4 PRIMARY HEALTH CARE Pub Date : 2024-12-01 DOI: 10.1016/j.semerg.2024.102381
M.D. Jiménez Cremers , M.E. Montes Belloso , E. Viudas Sainz , E. Pejenaute Labari
Lymphadenopathy is the alteration in the consistency or size of a lymph node. It is often associated with benign diseases, although factors such as gender, location, comorbidities, and the patient's age can increase the percentage of malignancy. Infections, tumors, and systemic diseases are its most common causes. Ultrasound allows the study of superficial and some deep lymph nodes through transverse and longitudinal planes, also using color Doppler to examine their vascularization. The ultrasound characteristics of a normal lymph node include an oval shape, well-defined borders, a long/short axis ratio > 2 cm, hypoechoic and homogeneous cortex, echogenic and vascularized central hilum, and short axis < 1 cm, except in certain cases.
Ultrasound is a useful tool that, in conjunction with the medical history, physical examination, and laboratory tests, allows for a diagnostic approach in the study of lymphadenopathy. It helps differentiate them from other processes and to make an early referral if necessary.
淋巴结病是指淋巴结稠度或大小的改变。它通常与良性疾病有关,尽管性别、位置、合并症和患者年龄等因素可增加恶性肿瘤的百分比。感染、肿瘤和全身性疾病是其最常见的原因。超声可以通过横向和纵向平面研究浅表和一些深层淋巴结,也可以使用彩色多普勒检查它们的血管化。正常淋巴结的超声特征包括椭圆形,边界清晰,长/短轴比>;2厘米,低回声且均匀的皮层,回声和血管化的中央门,短轴;1厘米,在某些情况下除外。超声是一种有用的工具,结合病史、体格检查和实验室检查,可以在淋巴结病的研究中找到诊断方法。它有助于将其与其他过程区分开来,并在必要时进行早期转诊。
{"title":"Uso de la ecografía clínica en atención primaria: adenopatías","authors":"M.D. Jiménez Cremers ,&nbsp;M.E. Montes Belloso ,&nbsp;E. Viudas Sainz ,&nbsp;E. Pejenaute Labari","doi":"10.1016/j.semerg.2024.102381","DOIUrl":"10.1016/j.semerg.2024.102381","url":null,"abstract":"<div><div>Lymphadenopathy is the alteration in the consistency or size of a lymph node. It is often associated with benign diseases, although factors such as gender, location, comorbidities, and the patient's age can increase the percentage of malignancy. Infections, tumors, and systemic diseases are its most common causes. Ultrasound allows the study of superficial and some deep lymph nodes through transverse and longitudinal planes, also using color Doppler to examine their vascularization. The ultrasound characteristics of a normal lymph node include an oval shape, well-defined borders, a long/short axis ratio<!--> <!-->&gt;<!--> <!-->2<!--> <!-->cm, hypoechoic and homogeneous cortex, echogenic and vascularized central hilum, and short axis<!--> <!-->&lt;<!--> <!-->1<!--> <!-->cm, except in certain cases.</div><div>Ultrasound is a useful tool that, in conjunction with the medical history, physical examination, and laboratory tests, allows for a diagnostic approach in the study of lymphadenopathy. It helps differentiate them from other processes and to make an early referral if necessary.</div></div>","PeriodicalId":53212,"journal":{"name":"Medicina de Familia-SEMERGEN","volume":"50 9","pages":"Article 102381"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142745381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uso de la ecografía clínica en atención primaria: ecografía en dolor cara posterior de la pierna 【临床超声在初级保健中的应用:超声在后肢疼痛中的应用】。
IF 0.9 Q4 PRIMARY HEALTH CARE Pub Date : 2024-12-01 DOI: 10.1016/j.semerg.2024.102403
E. Minguela Puras , C.A. Soto Castro , C. Vale Varela , J. Lafuente Pérez
Back leg pain is a common complaint in primary care and is especially linked to the sports and work field. The most common cause is trauma, which can lead to injuries that can range from tendinosis to ruptures, although other causes may imply more complex and serious pathology, such as venous thrombosis or arterial injuries. This type of pathology is also important because it can be the manifestation of neoplastic, infectious, or rheumatic disease.
Current technical advances in ultrasound equipment, added to increased availability, good cost-effectiveness ratio, good patient tolerance, and the chance to execute a real-time dynamic assessment, have made ultrasonography the technique of choice in leg pathology evaluation. For this reason, our current objective is to carry out a clear description of the technique that allows it to extend its use in routine clinical practice.
后腿痛是初级保健中常见的主诉,尤其与运动和工作领域有关。最常见的原因是创伤,它可能导致从肌腱断裂到断裂的损伤,尽管其他原因可能意味着更复杂和严重的病理,如静脉血栓形成或动脉损伤。这种类型的病理也很重要,因为它可能是肿瘤、感染性疾病或风湿病的表现。目前超声设备的技术进步,加上可用性的提高,良好的成本效益比,良好的患者耐受性,以及进行实时动态评估的机会,使超声检查成为腿部病理评估的首选技术。因此,我们当前的目标是对该技术进行清晰的描述,以便将其扩展到常规临床实践中。
{"title":"Uso de la ecografía clínica en atención primaria: ecografía en dolor cara posterior de la pierna","authors":"E. Minguela Puras ,&nbsp;C.A. Soto Castro ,&nbsp;C. Vale Varela ,&nbsp;J. Lafuente Pérez","doi":"10.1016/j.semerg.2024.102403","DOIUrl":"10.1016/j.semerg.2024.102403","url":null,"abstract":"<div><div>Back leg pain is a common complaint in primary care and is especially linked to the sports and work field. The most common cause is trauma, which can lead to injuries that can range from tendinosis to ruptures, although other causes may imply more complex and serious pathology, such as venous thrombosis or arterial injuries. This type of pathology is also important because it can be the manifestation of neoplastic, infectious, or rheumatic disease.</div><div>Current technical advances in ultrasound equipment, added to increased availability, good cost-effectiveness ratio, good patient tolerance, and the chance to execute a real-time dynamic assessment, have made ultrasonography the technique of choice in leg pathology evaluation. For this reason, our current objective is to carry out a clear description of the technique that allows it to extend its use in routine clinical practice.</div></div>","PeriodicalId":53212,"journal":{"name":"Medicina de Familia-SEMERGEN","volume":"50 9","pages":"Article 102403"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quiste de Nuck: un caso clínico en atención primaria [初级保健中肛门管囊肿1例报告]。
IF 0.9 Q4 PRIMARY HEALTH CARE Pub Date : 2024-12-01 DOI: 10.1016/j.semerg.2024.102400
Nerea Sánchez-Varela, Miguel Vidal-Gómez, Manuel Portela-Romero
{"title":"Quiste de Nuck: un caso clínico en atención primaria","authors":"Nerea Sánchez-Varela,&nbsp;Miguel Vidal-Gómez,&nbsp;Manuel Portela-Romero","doi":"10.1016/j.semerg.2024.102400","DOIUrl":"10.1016/j.semerg.2024.102400","url":null,"abstract":"","PeriodicalId":53212,"journal":{"name":"Medicina de Familia-SEMERGEN","volume":"50 9","pages":"Article 102400"},"PeriodicalIF":0.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative effectiveness of three common SARS-COV-2 vaccines: A network meta-analysis of randomized trials 三种常见SARS-COV-2疫苗的比较有效性:随机试验的网络荟萃分析
IF 0.9 Q4 PRIMARY HEALTH CARE Pub Date : 2024-11-29 DOI: 10.1016/j.semerg.2024.102343
A.A. Syed , F. Eqbal , H.R. Shamsi , A.R.S. Syed , S.J. Zakir , M. Fawzy , K.S. Khan

Background

Moderna, Pfizer, and AstraZeneca SARS-CoV-2 vaccines for preventing COVID-19 have regulatory approval in most countries. We conducted a network meta-analysis to compare their effectiveness.

Methods

We searched PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), ICTRP, and Clinicaltrials.gov for the randomized controlled trials (RCTs) published between 1st January 2020 and 1st February 2024. Eligible RCTs evaluated the Moderna, Pfizer or AstraZeneca vaccines among healthy individuals and reported the effectiveness of vaccination versus control measured with the outcome occurrence of COVID-19. We performed study selection, data extraction, and quality (risk of bias) assessment in duplicate. Network meta-analysis with random effects models was used to generate odds ratios (OR) with 95% confidence intervals (CI), evaluating heterogeneity statistically using I2 for direct comparisons and ranking vaccines hierarchically using the surface under the cumulative ranking curve (SUCRA). This study was registered on PROSPERO, CRD42023457957.

Findings

Of the 1954 initial citation, 18 RCTs (272,724 participants; 151,034 received one of the vaccines and 121,690 controls) that reported the outcome occurrence of COVID-19 were selected. Of these, 2 (11%) were moderate and 5 (28%) were high in quality. In network meta-analysis, all three vaccines were effective compared directly with control (Moderna OR 0.13, 95% CI 0.07–0.26, I2 97%; Pfizer OR 0.10, 95% CI 0.05–0.19, I2 78%; AstraZeneca OR 0.38, 95% CI 0.25–0.59, I2 63%). Indirect comparison of vaccines using control as the common comparator showed that AstraZeneca was less effective than Moderna (OR 2.84, 95% CI 1.32–6.12) and Pfizer (OR 3.94, 95% CI 1.80–8.60), while Moderna versus Pfizer showed no difference (OR 1.39, 95% CI 0.56–3.46). Vaccine SUCRA probabilities were higher for Pfizer than Moderna and AstraZeneca (92%, 75% and 33% respectively compared to control).

Interpretations

Pfizer ranks highest followed by Moderna (without a statistically significant difference) and AstraZeneca vaccines for preventing symptomatic COVID-19.
现代(moderna)、辉瑞(Pfizer)和阿斯利康(AstraZeneca)用于预防COVID-19的SARS-CoV-2疫苗已在大多数国家获得监管机构的批准。我们进行了网络荟萃分析来比较它们的有效性。方法检索PubMed、Cochrane Central Register of Controlled Trials (Central)、ICTRP和Clinicaltrials.gov,检索2020年1月1日至2024年2月1日发表的随机对照试验(RCTs)。符合条件的随机对照试验在健康个体中评估了Moderna、辉瑞或阿斯利康疫苗,并报告了以COVID-19的结果发生率衡量的疫苗接种与对照的有效性。我们一式两份进行了研究选择、数据提取和质量(偏倚风险)评估。使用随机效应模型的网络荟萃分析生成95%置信区间(CI)的优势比(OR),使用I2进行直接比较,在统计上评估异质性,并使用累积排序曲线下的曲面(SUCRA)对疫苗进行分层排序。本研究注册号为PROSPERO, CRD42023457957。1954年首次引用,18项随机对照试验(272,724名受试者;报告结果发生COVID-19的151,034名接种了其中一种疫苗,121,690名对照)被选中。其中,2个(11%)为中等质量,5个(28%)为高质量。在网络荟萃分析中,与对照组直接比较,这三种疫苗均有效(Moderna OR 0.13, 95% CI 0.07-0.26, I2 97%;辉瑞OR 0.10, 95% CI 0.05-0.19, I2 78%;阿斯利康OR 0.38, 95% CI 0.25-0.59, I2 63%)。以对照作为共同比较物的疫苗间接比较显示,阿斯利康的有效性低于Moderna (OR 2.84, 95% CI 1.32-6.12)和辉瑞(OR 3.94, 95% CI 1.80-8.60),而Moderna和辉瑞没有差异(OR 1.39, 95% CI 0.56-3.46)。辉瑞的疫苗SUCRA概率高于Moderna和阿斯利康(分别为92%、75%和33%)。InterpretationsPfizer排名最高,其次是Moderna(无统计学差异)和阿斯利康(AstraZeneca)预防症状性COVID-19疫苗。
{"title":"Comparative effectiveness of three common SARS-COV-2 vaccines: A network meta-analysis of randomized trials","authors":"A.A. Syed ,&nbsp;F. Eqbal ,&nbsp;H.R. Shamsi ,&nbsp;A.R.S. Syed ,&nbsp;S.J. Zakir ,&nbsp;M. Fawzy ,&nbsp;K.S. Khan","doi":"10.1016/j.semerg.2024.102343","DOIUrl":"10.1016/j.semerg.2024.102343","url":null,"abstract":"<div><h3>Background</h3><div>Moderna, Pfizer, and AstraZeneca SARS-CoV-2 vaccines for preventing COVID-19 have regulatory approval in most countries. We conducted a network meta-analysis to compare their effectiveness.</div></div><div><h3>Methods</h3><div>We searched PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), ICTRP, and Clinicaltrials.gov for the randomized controlled trials (RCTs) published between 1st January 2020 and 1st February 2024. Eligible RCTs evaluated the Moderna, Pfizer or AstraZeneca vaccines among healthy individuals and reported the effectiveness of vaccination <em>versus</em> control measured with the outcome occurrence of COVID-19. We performed study selection, data extraction, and quality (risk of bias) assessment in duplicate. Network meta-analysis with random effects models was used to generate odds ratios (OR) with 95% confidence intervals (CI), evaluating heterogeneity statistically using <em>I</em><sup>2</sup> for direct comparisons and ranking vaccines hierarchically using the surface under the cumulative ranking curve (SUCRA). This study was registered on PROSPERO, CRD42023457957.</div></div><div><h3>Findings</h3><div>Of the 1954 initial citation, 18 RCTs (272,724 participants; 151,034 received one of the vaccines and 121,690 controls) that reported the outcome occurrence of COVID-19 were selected. Of these, 2 (11%) were moderate and 5 (28%) were high in quality. In network meta-analysis, all three vaccines were effective compared directly with control (Moderna OR 0.13, 95% CI 0.07–0.26, <em>I</em><sup>2</sup> 97%; Pfizer OR 0.10, 95% CI 0.05–0.19, <em>I</em><sup>2</sup> 78%; AstraZeneca OR 0.38, 95% CI 0.25–0.59, <em>I</em><sup>2</sup> 63%). Indirect comparison of vaccines using control as the common comparator showed that AstraZeneca was less effective than Moderna (OR 2.84, 95% CI 1.32–6.12) and Pfizer (OR 3.94, 95% CI 1.80–8.60), while Moderna <em>versus</em> Pfizer showed no difference (OR 1.39, 95% CI 0.56–3.46). Vaccine SUCRA probabilities were higher for Pfizer than Moderna and AstraZeneca (92%, 75% and 33% respectively compared to control).</div></div><div><h3>Interpretations</h3><div>Pfizer ranks highest followed by Moderna (without a statistically significant difference) and AstraZeneca vaccines for preventing symptomatic COVID-19.</div></div>","PeriodicalId":53212,"journal":{"name":"Medicina de Familia-SEMERGEN","volume":"51 2","pages":"Article 102343"},"PeriodicalIF":0.9,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uso de la ecografía clínica en el ámbito extrahospitalario y la sospecha de fractura de cadera [临床超声波检查在院前医疗和疑似髋部骨折中的应用]。
IF 0.9 Q4 PRIMARY HEALTH CARE Pub Date : 2024-11-20 DOI: 10.1016/j.semerg.2024.102366
C. Montero Peña , M. Carmona González , G. Rodríguez Parejo , I. de Miguel Silvestre , M. Rivera Teijido
{"title":"Uso de la ecografía clínica en el ámbito extrahospitalario y la sospecha de fractura de cadera","authors":"C. Montero Peña ,&nbsp;M. Carmona González ,&nbsp;G. Rodríguez Parejo ,&nbsp;I. de Miguel Silvestre ,&nbsp;M. Rivera Teijido","doi":"10.1016/j.semerg.2024.102366","DOIUrl":"10.1016/j.semerg.2024.102366","url":null,"abstract":"","PeriodicalId":53212,"journal":{"name":"Medicina de Familia-SEMERGEN","volume":"50 9","pages":"Article 102366"},"PeriodicalIF":0.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Análisis de las notificaciones realizadas en el Sistema de Notificación y Aprendizaje para la Seguridad del Paciente en una comunidad autónoma [一个自治区病人安全通知和学习系统的通知分析]。
IF 0.9 Q4 PRIMARY HEALTH CARE Pub Date : 2024-11-20 DOI: 10.1016/j.semerg.2024.102342
M.J. Pérez Taboada , A. Rodríguez Núñez , R. Bugarín González

Objective

Analyze the notifications made by Primary Care (PC) professionals of Galicia, in the Notification and Learning system for Patient Safety (SiNASP), of the Ministry of Health of Spain, its variables and the factors that contribute to its appearance for thus characterize security incidents in this healthcare field.

Materials and methods

This is a retrospective descriptive study of notifications made in PC, between October 2010 and December 2019, in the SiNASP, in the Autonomous Community of Galicia. The data are presented using absolute and relative frequencies. Incidents are determined on the total number of personnel of different professional categories. To contrast the relationship between different variables, the Chi-square test was used.

Results

1863 notifications corresponded to PC (10% of the total). There were no differences in terms of sex, but it was observed that the incidence increases with age.
The largest number of notifications was made by doctors, although, in percentage terms, pharmacists are the professionals who report the most incidents.
The largest number of safety events occurred in consultations, with the most frequent being those due to a problem related to medication. Approximately 1 in every 200 incidents that reached the patient were classified as catastrophic.

Conclusions

Even though there are fewer notifications and possibly having a lower incidence than in hospitals, security incidents in PC are frequent and, sometimes, serious. Therefore, measures that influence the promotion of safety culture and raise awareness, in this sense, among managers and professionals in this healthcare field are essential.
目的分析加利西亚初级保健(PC)专业人员在西班牙卫生部患者安全通知和学习系统(SiNASP)中发出的通知、其变量以及导致其出现的因素,从而确定该医疗保健领域安全事件的特征:这是一项回顾性描述性研究,研究对象是加利西亚自治区在 2010 年 10 月至 2019 年 12 月期间向 SiNASP 发送的 PC 通知。数据采用绝对频率和相对频率表示。事件是根据不同专业类别的人员总数确定的。为了对比不同变量之间的关系,采用了卡方检验法:有 1863 份通知与 PC 有关(占总数的 10%)。在性别方面没有差异,但随着年龄的增长,发病率也在增加。尽管从百分比来看,药剂师是报告事件最多的专业人员,但医生报告的事件数量最多。咨询中发生的安全事件最多,其中最常见的是与药物有关的问题。大约每 200 起发生在患者身上的事件中就有 1 起被归类为灾难性事件:尽管 PC 中的安全事件通知较少,发生率也可能比医院低,但 PC 中的安全事件频繁发生,有时甚至很严重。因此,必须采取措施促进安全文化的发展,并从这个意义上提高医疗保健领域管理人员和专业人员的安全意识。
{"title":"Análisis de las notificaciones realizadas en el Sistema de Notificación y Aprendizaje para la Seguridad del Paciente en una comunidad autónoma","authors":"M.J. Pérez Taboada ,&nbsp;A. Rodríguez Núñez ,&nbsp;R. Bugarín González","doi":"10.1016/j.semerg.2024.102342","DOIUrl":"10.1016/j.semerg.2024.102342","url":null,"abstract":"<div><h3>Objective</h3><div>Analyze the notifications made by Primary Care (PC) professionals of Galicia, in the Notification and Learning system for Patient Safety (SiNASP), of the Ministry of Health of Spain, its variables and the factors that contribute to its appearance for thus characterize security incidents in this healthcare field.</div></div><div><h3>Materials and methods</h3><div>This is a retrospective descriptive study of notifications made in PC, between October 2010 and December 2019, in the SiNASP, in the Autonomous Community of Galicia. The data are presented using absolute and relative frequencies. Incidents are determined on the total number of personnel of different professional categories. To contrast the relationship between different variables, the Chi-square test was used.</div></div><div><h3>Results</h3><div>1863 notifications corresponded to PC (10% of the total). There were no differences in terms of sex, but it was observed that the incidence increases with age.</div><div>The largest number of notifications was made by doctors, although, in percentage terms, pharmacists are the professionals who report the most incidents.</div><div>The largest number of safety events occurred in consultations, with the most frequent being those due to a problem related to medication. Approximately 1 in every 200 incidents that reached the patient were classified as catastrophic.</div></div><div><h3>Conclusions</h3><div>Even though there are fewer notifications and possibly having a lower incidence than in hospitals, security incidents in PC are frequent and, sometimes, serious. Therefore, measures that influence the promotion of safety culture and raise awareness, in this sense, among managers and professionals in this healthcare field are essential.</div></div>","PeriodicalId":53212,"journal":{"name":"Medicina de Familia-SEMERGEN","volume":"51 2","pages":"Article 102342"},"PeriodicalIF":0.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
¿Qué pasa cuando el paciente dice «no»? Traslado involuntario a un servicio de urgencias hospitalarias: a propósito de un caso [当病人说 "不 "时会发生什么?非自愿转院急救服务:与一个案例有关]。
IF 0.9 Q4 PRIMARY HEALTH CARE Pub Date : 2024-11-20 DOI: 10.1016/j.semerg.2024.102349
N. Echepare Oraá , L. Gómez Bernardo , L. Gordo Murillo , E. Cobos López , A. Alonso Hernán
{"title":"¿Qué pasa cuando el paciente dice «no»? Traslado involuntario a un servicio de urgencias hospitalarias: a propósito de un caso","authors":"N. Echepare Oraá ,&nbsp;L. Gómez Bernardo ,&nbsp;L. Gordo Murillo ,&nbsp;E. Cobos López ,&nbsp;A. Alonso Hernán","doi":"10.1016/j.semerg.2024.102349","DOIUrl":"10.1016/j.semerg.2024.102349","url":null,"abstract":"","PeriodicalId":53212,"journal":{"name":"Medicina de Familia-SEMERGEN","volume":"51 2","pages":"Article 102349"},"PeriodicalIF":0.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Medicina de Familia-SEMERGEN
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1