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A formal evaluation of The Ottawa Hospital Pain Clinic orientation session: A quality improvement project. 渥太华医院疼痛诊所的培训课程的正式评估:质量改进项目。
IF 2.4 Q3 CLINICAL NEUROLOGY Pub Date : 2023-01-01 DOI: 10.1080/24740527.2022.2111993
Patricia A Poulin, Louise Bell, Danielle Rice, Yaadwinder Shergill, Sarah Fitzgerald, Rosemee Cantave, Renée Gauthier, Rose Robbins, Cristin Kargus, Susan Ward

Background: Chronic pain affects approximately one in every five Canadians and has a substantial impact on psychological well-being, relationships, ability to attend work or school, and overall functioning.The Ottawa Hospital Pain Clinic introduced orientation sessions, with the aim of providing new patients with pain education to help prepare patients for engagement with multimodal pain management strategies. This report summarizes the results of a formative evaluation of the orientation session at The Ottawa Hospital Pain Clinic to determine whether patients perceived the orientation session as beneficial.

Methods: Interviews were conducted, transcribed, and then thematically analyzed to understand patients' perspectives on the orientation session. Coding was done by two team members using the constant comparison analyses method with key ideas, concepts, and patterns identified and compared to identify similarities.

Results: Between September 6 and October 18, 2019, 18 patients attended an orientation session and 12 consented to participation and completed telephone interviews. The six themes identified included (1) feeling of community, (2) participants feeling heard by providers, (3) appreciation of the holistic approach, (4) availability of community resources, (5) barriers to access, and (6) discordant feelings of preparedness for the physician appointment.

Conclusion: Results from this evaluation indicate that the orientation session offered at The Ottawa Hospital Pain Clinic improves chronic pain literacy, reduces feeling of isolation, and instills hope. As such, it appears to be a valuable component of pain clinic programs.

背景:慢性疼痛影响着大约五分之一的加拿大人,并对心理健康、人际关系、参加工作或学习的能力和整体功能产生重大影响。渥太华医院疼痛诊所引入了定向会议,目的是为新患者提供疼痛教育,帮助患者准备参与多模式疼痛管理策略。本报告总结了在渥太华医院疼痛诊所的介绍会形成性评估的结果,以确定患者是否认为介绍会是有益的。方法:对访谈进行记录,然后进行主题分析,以了解患者对迎新会的看法。编码是由两个团队成员使用持续的比较分析方法完成的,其中确定了关键思想、概念和模式,并进行了比较,以确定相似性。结果:2019年9月6日至10月18日,18名患者参加了迎新会,12名患者同意参加并完成了电话访谈。确定的六个主题包括(1)社区感觉,(2)参与者感觉被提供者听到,(3)对整体方法的欣赏,(4)社区资源的可用性,(5)获取障碍,以及(6)对医生预约的准备不一致的感觉。结论:本评估结果表明,渥太华医院疼痛诊所提供的培训课程提高了慢性疼痛知识,减少了孤独感,并灌输了希望。因此,它似乎是疼痛临床项目的一个有价值的组成部分。
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引用次数: 0
Examining the roles of depression, pain catastrophizing, and self-efficacy in quality of life changes following chronic pain treatment. 研究慢性疼痛治疗后抑郁、疼痛灾难化和自我效能在生活质量改变中的作用。
IF 2.4 Q3 CLINICAL NEUROLOGY Pub Date : 2023-01-01 DOI: 10.1080/24740527.2022.2156330
Landon T Montag, Tim V Salomons, Rosemary Wilson, Scott Duggan, Etienne J Bisson

Background: Adults with chronic pain have a lower quality of life (QOL) compared to the general population. Chronic pain requires specialized treatment to address the multitude of factors that contribute to an individual's pain experience, and effectively managing pain requires a biopsychosocial approach to improve patients' QOL.

Aim: This study examined adults with chronic pain after a year of specialized treatment to determine the role of cognitive markers (i.e., pain catastrophizing, depression, pain self-efficacy) in predicting changes in QOL.

Methods: Patients in an interdisciplinary chronic pain clinic (N = 197) completed measures of pain catastrophizing, depression, pain self-efficacy, and QOL at baseline and 1 year later. Correlations and a moderated mediation were completed to understand the relationships between the variables.

Results: Higher baseline pain catastrophizing was significantly associated with increased mental QOL (b = 0.39, 95% confidence interval [CI] 0.141; 0.648) and decreased depression (b = -0.18, 95% CI -0.306; -0.052) over a year. Furthermore, the relationship between baseline pain catastrophizing and the change in depression was moderated by the change in pain self-efficacy (b = -0.10, 95% CI -0.145; -0.043) over a year. Patients with high baseline pain catastrophizing reported decreased depression after a year of treatment, which was associated with greater QOL improvements but only in patients with unchanged or improved pain self-efficacy.

Conclusions: Our findings highlight the roles of cognitive and affective factors and their impact on QOL in adults with chronic pain. Understanding the psychological factors that predict increased mental QOL is clinically useful, because medical teams can optimize these positive changes in QOL through psychosocial interventions aimed at improving patients' pain self-efficacy.

背景:与一般人群相比,患有慢性疼痛的成年人的生活质量(QOL)较低。慢性疼痛需要专门的治疗,以解决导致个体疼痛体验的多种因素,有效地管理疼痛需要生物心理社会方法来改善患者的生活质量。目的:本研究调查了经过一年专门治疗的慢性疼痛成人,以确定认知标记(即疼痛灾难化,抑郁,疼痛自我效能)在预测生活质量变化中的作用。方法:在交叉学科慢性疼痛门诊(N = 197)的患者在基线和1年后完成疼痛灾难、抑郁、疼痛自我效能和生活质量的测量。完成了相关性和有调节的中介,以了解变量之间的关系。结果:基线疼痛灾难化程度越高,心理生活质量越高(b = 0.39, 95%可信区间[CI] 0.141;0.648)和抑郁减少(b = -0.18, 95% CI -0.306;-0.052)。此外,基线疼痛灾难化与抑郁变化之间的关系被疼痛自我效能的变化所缓和(b = -0.10, 95% CI -0.145;-0.043)。高基线疼痛灾难化的患者在治疗一年后报告抑郁减少,这与更大的生活质量改善有关,但仅适用于疼痛自我效能不变或改善的患者。结论:我们的研究结果突出了认知和情感因素在成人慢性疼痛患者生活质量中的作用及其影响。了解预测精神生活质量增加的心理因素在临床上是有用的,因为医疗团队可以通过旨在提高患者疼痛自我效能的社会心理干预来优化这些积极的生活质量变化。
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引用次数: 0
Delivering Team-Based Primary Care for the Management of Chronic Low Back Pain: An Interpretive Description Qualitative Study of Healthcare Provider Perspectives. 提供以团队为基础的初级保健管理慢性腰痛:医疗保健提供者视角的解释性描述定性研究。
IF 2.4 Q3 CLINICAL NEUROLOGY Pub Date : 2023-01-01 DOI: 10.1080/24740527.2023.2226719
Kyle Vader, Catherine Donnelly, Therese Lane, Gillian Newman, Dean A Tripp, Jordan Miller

Background: Chronic low back pain (LBP) is a prevalent and disabling health issue. Team-based models of primary care are ideally positioned to provide comprehensive care for patients with chronic LBP. A better understanding of primary care team perspectives can inform future efforts to improve how team-based care is provided for patients with chronic LBP in this practice setting.

Aims: The aim of this study was to understand health care providers' experiences, perceived barriers and facilitators, and recommendations when providing team-based primary care for the management of chronic LBP.

Methods: We conducted an interpretive description qualitative study based on focus group discussions with health care providers from team-based primary care settings in Ontario, Canada. Data were analyzed using thematic analysis.

Results: We conducted five focus groups with five different primary care teams, including a total of 31 health care providers. We constructed four themes (each with subthemes) related to experiences, perceived barriers and facilitators, and recommendations to providing team-based primary care for the management of chronic LBP, including (1) care pathways and models of service delivery, (2) team processes and organization, (3) team culture and environment, and (4) patient needs and readiness.

Conclusions: Primary care teams are implementing diverse care pathways and models of service delivery for the management of patients with chronic LBP, which can be influenced by patient, team, and organizational factors. Results have potential implications for future research and practice innovations to improve how team-based primary care is delivered for patients with chronic LBP.

背景:慢性腰痛(LBP)是一种普遍和致残的健康问题。以团队为基础的初级保健模式是为慢性腰痛患者提供全面护理的理想定位。更好地了解初级保健团队的观点可以为未来的努力提供信息,以改善在这种实践环境中如何为慢性腰痛患者提供基于团队的护理。目的:本研究的目的是了解卫生保健提供者的经验,感知障碍和促进因素,以及在提供以团队为基础的初级保健管理慢性腰痛时的建议。方法:我们在加拿大安大略省以团队为基础的初级保健机构的卫生保健提供者焦点小组讨论的基础上进行了一项解释性描述定性研究。数据采用专题分析进行分析。结果:我们对5个不同的初级保健小组进行了5个焦点小组,包括31名卫生保健提供者。我们构建了四个主题(每个主题都有子主题),涉及经验、感知障碍和促进因素,以及为慢性腰痛管理提供基于团队的初级保健的建议,包括(1)护理途径和服务提供模式,(2)团队流程和组织,(3)团队文化和环境,以及(4)患者需求和准备。结论:初级保健团队正在实施多种护理途径和服务模式,以管理慢性腰痛患者,这可能受到患者,团队和组织因素的影响。结果对未来的研究和实践创新具有潜在的意义,可以改善以团队为基础的初级保健如何为慢性腰痛患者提供服务。
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引用次数: 0
Rationale, methods, and progress of the ArthroCaP Study: A prospective cohort study exploring the associations between chronic postsurgical pain and postoperative cognitive dysfunction after elective knee or hip arthroplasty 关节cap研究的基本原理、方法和进展:一项前瞻性队列研究,探讨选择性膝关节或髋关节置换术后慢性术后疼痛与术后认知功能障碍之间的关系
IF 2.4 Q3 CLINICAL NEUROLOGY Pub Date : 2022-12-22 DOI: 10.1080/24740527.2022.2162375
Maram Khaled, Jocelyn Kuber, Mary Ferber, Praveen Sritharan, Yarden Levy, S. Becker, M. Fahnestock, M. Griffin, K. Madden, H. Shanthanna, M. Marcucci
ABSTRACT Background Chronic postsurgical pain (CPSP) may increase the risk of postoperative cognitive dysfunction (POCD) directly or by negatively impacting mobility. A comprehensive measure of satisfaction with surgery that accounts for ability to perform activities might be even more strongly associated with POCD. There might be complex mechanisms underlying the interplays between postoperative pain and cognition. Aims The primary objective is to explore whether CPSP at 6 months is associated with POCD (≥2-point decline in the Montreal Cognitive Assessment [MoCA] compared to preoperative) at 12 months. Secondary objectives are to explore the association between satisfaction with surgery and POCD, the role of pain medications (opioids) in the association between CPSP and POCD, the role of patient preoccupation/optimism and coping in determining the effect of pain on cognition, and the hypothesis of neurogenesis interference as an underlying mechanism. Methods We will prospectively recruit ≥100 patients ≥50 years old undergoing elective total knee/hip arthroplasty. Sociodemographic characteristics, comorbidities, frailty, pain, and pain medications will be assessed preoperatively. The Somatic Preoccupation and Coping questionnaire will be administered preoperatively and 4 to 6 weeks postoperative. Pain and the Self-Administered Patient Satisfaction Scale will be measured at 3 and 6 months. MoCA and neuropsychological tests will be administered at baseline, 4 to 6 weeks, and 6 and 12 months. Blood will be longitudinally collected for biomarker analysis. Progress Forty-six participants have been enrolled in the study so far. Conclusion ArthroCaP will provide preliminary data on the association of CPSP and patient satisfaction with POCD and underlying mechanisms. It will inform larger confirmatory and interventional studies to enhance the benefits of surgery.
摘要背景慢性术后疼痛(CPSP)可能直接或通过负面影响行动能力而增加术后认知功能障碍(POCD)的风险。对手术满意度的全面衡量,包括进行活动的能力,可能与POCD更密切相关。术后疼痛和认知之间的相互作用可能有复杂的机制。目的:主要目的是探讨6个月时的CPSP是否与12个月时POCD(与术前相比,蒙特利尔认知评估[MoCA]下降≥2分)相关。次要目标是探索手术满意度与POCD之间的关系,止痛药(阿片类药物)在CPSP和POCD之间关系中的作用,患者专注/乐观和应对在决定疼痛对认知影响中的作用以及神经发生干扰作为潜在机制的假说。方法我们将前瞻性地招募≥100名年龄≥50岁的患者进行选择性全膝/髋关节置换术。术前将评估社会形态特征、合并症、虚弱、疼痛和止痛药。术前和术后4至6周将进行躯体活动前和应对问卷调查。疼痛和自我管理患者满意度量表将在3个月和6个月时进行测量。MoCA和神经心理测试将在基线、4-6周、6个月和12个月进行。将纵向采集血液用于生物标志物分析。到目前为止,已有46名参与者参与了这项研究。结论ArthroCaP将为CPSP和患者满意度与POCD的关系及其潜在机制提供初步数据。它将为更大规模的验证性和介入性研究提供信息,以提高手术的益处。
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引用次数: 0
Is chronic pain as an autoimmune disease? 慢性疼痛是一种自身免疫性疾病吗?
IF 2.4 Q3 CLINICAL NEUROLOGY Pub Date : 2022-12-22 DOI: 10.1080/24740527.2023.2175205
Gurmit Singh
ABSTRACT Autoimmune diseases frequently occur in females, and a parallel sexually dimorphic suffering is observed in individuals who suffer chronic pain. Though perception and environment influence the chronicity of pain, this review illustrates examples of specific, evolutionarily preserved, physiological parameters that may be responsible and differentially contribute to chronic pain and affect treatment outcomes in females and males. In females, the immune system may be continuously “primed,” potentially due to the presence of two X chromosomes, each bearing a number of genes involved in immune responsiveness. In the event of nerve injury, declining parity rates could be having repercussions via increased rates of chronic pain or less effectiveness to therapies, which may be associated with a heightened immune cell infiltration into damage-associated sites. Additionally, the female hormone estradiol is both neuroprotective and neurodegenerative, with reproductive cycle– and age-dependent outcomes. There is therefore a need to study neuro-immune-endocrine crosstalk in the context of chronic pain. Autoantibodies have been associated to neural antigens with sensory pathway hyperexcitability in patients, and self-antigens need to be identified by damaged nerves remain to be discovered. Specific T cells release pronociceptive cytokines that directly influence neural firing, and T lymphocytes reactivated by specific antigens may elicit neuroprotective effects by secreting factors that support nerve repair. Modulating immune cells could therefore be a mechanism by which nerve recovery is promoted, with sex-specific outcomes. Investigating neuroimmune homeostasis may inform the selection of specific treatment regimens for females or males and hence may improve chronic pain management by recalibrating the influence of the immune system on the nervous system.
自身免疫性疾病经常发生在女性中,并且在患有慢性疼痛的个体中观察到平行的两性二态痛苦。虽然感知和环境会影响疼痛的慢性性,但这篇综述阐述了一些特定的、进化上保存下来的生理参数,这些参数可能是导致慢性疼痛的原因,并对女性和男性的治疗结果有不同的影响。在女性中,免疫系统可能会持续“启动”,这可能是由于两条X染色体的存在,每条X染色体都携带一些与免疫反应有关的基因。在神经损伤的情况下,胎次率的下降可能通过慢性疼痛率的增加或治疗效果的降低而产生影响,这可能与免疫细胞浸润到损伤相关部位的增加有关。此外,雌性激素雌二醇既具有神经保护作用,又具有神经退行性,其结果与生殖周期和年龄有关。因此,有必要在慢性疼痛的背景下研究神经-免疫-内分泌的相互作用。自身抗体与患者感觉通路高兴奋性的神经抗原相关,而自身抗原需要通过受损神经来识别,仍有待发现。特异性T细胞释放直接影响神经放电的前感觉细胞因子,被特异性抗原重新激活的T淋巴细胞可能通过分泌支持神经修复的因子而引起神经保护作用。因此,调节免疫细胞可能是促进神经恢复的一种机制,具有性别特异性的结果。研究神经免疫稳态可以为女性或男性的特定治疗方案的选择提供信息,从而可以通过重新校准免疫系统对神经系统的影响来改善慢性疼痛的管理。
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引用次数: 1
Presurgical rehabilitation program for patients with symptomatic lumbar spinal stenosis: A pilot randomized controlled trial protocol 有症状腰椎管狭窄患者的手术前康复方案:一项随机对照试验方案
IF 2.4 Q3 CLINICAL NEUROLOGY Pub Date : 2022-10-18 DOI: 10.1080/24740527.2022.2137009
Nora Bakaa, D. Gross, L. Carlesso, J. Macdermid, K. Thomas, Florence Slomp, A. Rushton, M. Miciak, R. Smeets, R. Rampersaud, A. Nataraj, B. Drew, Pahuta Markian, D. Guha, A. Cenic, Luciana G Macedo
ABSTRACT Background Symptomatic lumbar spinal stenosis (SLSS) is the most common diagnosis associated with spine surgery for those over the age of 55 years. There is a lack of quality research on the effectiveness of prehabilitation on pain, function, and quality of life in patients undergoing surgery for SLSS. This pilot randomized controlled trial (RCT) will evaluate the feasibility of an eHealth prehabilitation program for individuals undergoing SLSS surgery, and an embedded longitudinal qualitative study explores the perioperative patient experience and recovery trajectory. Methods Participants (n = 60) undergoing spine surgery for LSS will be randomized into the 8-week electronic health (eHealth) prehabilitation program or minimal intervention. The prehabilitation program will be delivered virtually using synchronous (one-on-one) and asynchronous (independent) sessions by an experienced clinician, consisting of motivational interviewing, exercise (graded activity), education, peer support groups, and a 6-week booster session. Participants in the minimal care group will receive usual care and will have access to educational videos. Primary outcomes will include (1) recruitment, (2) patient adherence, (3) acceptability of program content, (4) acceptability and compliance with study questionnaires, and (5) attrition. Outcomes will be assessed at baseline, after the intervention, and 3 and 12 months postoperatively. We will conduct semistructured interviews alongside the RCT with 12 to 15 participants. Discussion The proposed project will include the feasibility testing of an eHealth LSS prehabilitation program with potential to improve surgical outcomes. Results of this study will provide the foundation for future fully powered multicenter RCTs. Trial Registration clinicaltrials.gov NCT05073081
摘要背景症状性腰椎管狭窄症(SLSS)是55岁以上脊柱手术最常见的诊断。对接受SLSS手术的患者的疼痛、功能和生活质量的康复效果缺乏高质量的研究。这项试点随机对照试验(RCT)将评估接受SLSS手术的个体的eHealth康复计划的可行性,并进行一项嵌入式纵向定性研究,探索围手术期患者体验和康复轨迹。方法接受LSS脊柱手术的参与者(n=60)将被随机分配到为期8周的电子健康(eHealth)康复计划或最小干预中。康复计划将由经验丰富的临床医生通过同步(一对一)和异步(独立)课程进行,包括动机访谈、锻炼(分级活动)、教育、同伴支持小组和为期6周的强化课程。最低护理组的参与者将接受常规护理,并可以观看教育视频。主要结果包括(1)招募,(2)患者依从性,(3)项目内容的可接受性,(4)研究问卷的可接受度和依从性,以及(5)流失。结果将在基线、干预后以及术后3个月和12个月进行评估。我们将与随机对照试验一起进行半结构化访谈,共有12至15名参与者。讨论拟议项目将包括电子健康LSS康复计划的可行性测试,该计划有可能改善手术效果。这项研究的结果将为未来的全功率多中心随机对照试验奠定基础。试验注册clinicaltrials.gov NCT05073081
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引用次数: 0
Opioid reduction and enhanced recovery in orthopaedic surgery (OREOS): A feasibility randomized controlled trial in knee replacement patients. 骨科手术(OREOS)中阿片类药物减少和增强康复:一项膝关节置换术患者的可行性随机对照试验。
IF 2.4 Q3 CLINICAL NEUROLOGY Pub Date : 2022-10-04 eCollection Date: 2022-01-01 DOI: 10.1080/24740527.2022.2102465
Sushmitha Pallapothu, Kim Madden, Anthony Adili, Adrijana Krsmanovic, Matilda Nowakowski, Tara Packham, Sidra Shoaib, Lehana Thabane, Jean-Eric Tarride, Daniel Tushinski, Harsha Shanthanna

Background: Total knee arthroplasties are the second most common surgery in Canada. Most patients recover well, but 20% or more still suffer from persistent pain and opioid use. Though opioids are an important part of perioperative pain management, their potential for long-term adverse effects is well recognized. Limiting opioids may be insufficient to overcome the issue of opioid overuse. Pain and opioid use are highly linked, so an effective alternative needs to address both issues.

Objectives: The principal objective of this pilot trial is to assess the feasibility. The clinical objectives are to determine the effects of a multicomponent care pathway on opioid-free pain control, persisting pain and opioid use, functional knee outcomes, quality of life, and return to function.

Methods: We will include adult patients scheduled for primary elective total knee arthroplasty. Patients in the intervention group will undergo a multicomponent intervention pathway that will be facilitated by an intervention coordinator linking each patient and their surgical/ perioperative team. The interventional pathway will include (1) preoperative education on pain and opioid use, (2) preoperative risk identification and mitigation using cognitive behavioral skills, (3) personalized postdischarge analgesic prescriptions, and (4) continued support for pain control and recovery up to 8 weeks. Patients in the control group will receive the usual care at their institution.

Discussion: The overarching goal is to implement and evaluate a coordinated approach to clinical care to improve pain control and reduce harms, with an emphasis on patient-centered care and shared decision making.Trial Registration Number: NCT04968132 (informed consent/ research ethics board statement).

背景:全膝关节置换术是加拿大第二大常见手术。大多数患者恢复良好,但20%或更多的患者仍然遭受持续疼痛和阿片类药物的困扰。虽然阿片类药物是围手术期疼痛管理的重要组成部分,但其潜在的长期不良反应是公认的。限制阿片类药物可能不足以克服阿片类药物过度使用的问题。疼痛和阿片类药物的使用是高度相关的,所以一个有效的替代方案需要同时解决这两个问题。目的:本试验的主要目的是评估可行性。临床目的是确定多组分护理途径对无阿片类药物疼痛控制、持续疼痛和阿片类药物使用、膝关节功能结局、生活质量和功能恢复的影响。方法:我们将纳入预定进行初级选择性全膝关节置换术的成年患者。干预组的患者将接受多组分干预途径,干预协调员将每位患者及其手术/围手术期团队联系起来。介入途径将包括(1)术前关于疼痛和阿片类药物使用的教育,(2)术前使用认知行为技能识别和缓解风险,(3)个性化出院后镇痛处方,以及(4)持续支持长达8周的疼痛控制和恢复。对照组患者将在其所在机构接受常规护理。讨论:总体目标是实施和评估一种协调的临床护理方法,以改善疼痛控制和减少伤害,强调以患者为中心的护理和共同决策。试验注册号:NCT04968132(知情同意/研究伦理委员会声明)。
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引用次数: 0
Clinical Innovation Poster Abstracts 临床创新海报摘要
IF 2.4 Q3 CLINICAL NEUROLOGY Pub Date : 2022-08-12 DOI: 10.1080/24740527.2022.2088026
D. Anghelescu, Heidi Meeks, Michael J Frett, Latika Puri, N. Alberts, M. Bordeleau, J. Vollert, M. Backonja, Serge Marchand
St. Jude Children’s Research Hospital, Pediatric Medicine, Memphis, Tennessee, United States; St. Jude Children’s Research Hospital, Pediatric Medicine, Memphis, Tennessee, United States; St. Jude Children’s Research Hospital, Pediatric Medicine, Memphis, Tennessee, United States; Loma Linda University, Pediatrics, Loma Linda, California, USA; Concordia University, Psychology, Montreal, Quebec, Canada
圣犹达儿童研究医院,儿科医学,美国田纳西州孟菲斯;圣犹达儿童研究医院,儿科医学,美国田纳西州孟菲斯;圣犹达儿童研究医院,儿科医学,美国田纳西州孟菲斯;洛马琳达大学,儿科,美国加利福尼亚州洛马琳达;康考迪亚大学,心理学,加拿大魁北克省蒙特利尔
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引用次数: 0
Research Poster Abstracts 研究海报摘要
IF 2.4 Q3 CLINICAL NEUROLOGY Pub Date : 2022-08-12 DOI: 10.1080/24740527.2022.2088027
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引用次数: 1
Symposia Abstracts 会议摘要
IF 2.4 Q3 CLINICAL NEUROLOGY Pub Date : 2022-08-12 DOI: 10.1080/24740527.2022.2088025
Nader Ghasemlou, Bradley Kerr, Vivianne Tawfik
Symposium Abstract: Females are disproportionately affected by chronic pain compared to males, with a higher prevalence of pain conditions including arthritis, migraine and fibromyalgia, among others. Seminal work from various laboratories has shown that differing inflammatory responses underlie some of the sexual dimorphism observed in the regulation of pain. While it is now clear that interactions between the nervous and immune systems are critical mediators of both acute and chronic pain responses, the underlying molecular and cellular mechanisms controlling these differences remain poorly understood. We will present evidence from our respective laboratories showing how sexually dimorphic responses in neuroimmunity help control pain using models of multiple sclerosis (Dr. Bradley Kerr), complex regional pain syndrome (Dr. Vivianne Tawfik), and in the baseline control of nociception (Dr. Nader Ghasemlou). Abstract Activated myeloid-lineage cells, macrophages peripherally and microglia centrally, contribute to the acute-to-chronic pain transition, however, the details on the timing and possible sex-specificity of such involvement remains a matter of debate. For example, there is evidence that CNS microglia may contribute to chronic pain only in males. In this talk I will discuss data from my laboratory using complementary pharma-cologic and transgenic approaches in mice to more specifically manipulate myeloid-lineage cells using a model of the pain condition, complex regional pain syndrome. I will discuss a novel spatiotemporal transgenic mouse line, Cx3CR1-Cre ERT2 -eYFP;TLR4 fl/fl (TLR4 cKO) that we used to specifically knock out toll-like receptor 4 (TLR4), only in microglia and no other myeloid-lineage cells. Using this transgenic mouse, we find that early TLR4 cKO results in profound improvement in chronic, but not acute, allodynia in males, with a significant but less robust effect in females. In contrast, late TLR4 cKO results in partial improvement in allodynia in both sexes, suggesting that downstream cellular or molecular TLR4-independent events may have already been triggered. I will further discuss new data using a transgenic mouse that allows for microglia-specific depletion, Cx3CR1-Cre ERT2 -eYFP;iDTR lox-STOP-lox (microglia cKO). We performed microglial depletion at multiple time points after peripheral injury and see the most striking decrease in mechanical allodynia in males and females when depletion is performed several weeks after injury. Overall, Symposium Abstract: Observing the pain of brings about a cascade of biological and psychological in the self For caregivers and loved ones of individuals in pain, the ability to adaptively manage these reactions is closely related to the ability to provide appropriate pain assessment and pain management behaviours. This three-part symposium examines the psychological, physiological, and neural responses of individuals observing their loved ones as they undergo a range of painful exp
摘要:与男性相比,女性更容易受到慢性疼痛的影响,包括关节炎、偏头痛和纤维肌痛等疼痛状况的患病率更高。来自不同实验室的开创性工作表明,不同的炎症反应是疼痛调节中观察到的一些性别二态性的基础。虽然现在很清楚,神经和免疫系统之间的相互作用是急性和慢性疼痛反应的关键介质,但控制这些差异的潜在分子和细胞机制仍然知之甚少。我们将展示来自我们各自实验室的证据,展示神经免疫中的两性二态反应如何帮助多发性硬化症(Bradley Kerr博士)、复杂局部疼痛综合征(Vivianne Tawfik博士)和痛感基线控制(Nader Ghasemlou博士)的模型控制疼痛。活化的髓系细胞,外周巨噬细胞和中枢小胶质细胞,有助于急性到慢性疼痛的转变,然而,关于这种参与的时间和可能的性别特异性的细节仍然是一个争论的问题。例如,有证据表明中枢神经系统小胶质细胞可能仅在男性中导致慢性疼痛。在这次演讲中,我将讨论从我的实验室获得的数据,使用互补的药理学和转基因方法在小鼠中更具体地操纵髓系细胞,使用疼痛状况模型,复杂的局部疼痛综合征。我将讨论一种新的时空转基因小鼠系,Cx3CR1-Cre ERT2 -eYFP;TLR4 fl/fl (TLR4 cKO),我们用来特异性敲除toll样受体4 (TLR4),仅在小胶质细胞中,而不是其他髓系细胞中。使用这种转基因小鼠,我们发现早期TLR4 cKO对男性慢性而非急性异常性疼痛有显著改善,对女性有显著但不那么强大的作用。相比之下,TLR4晚期cKO导致两性异常性痛的部分改善,这表明下游细胞或分子TLR4独立事件可能已经被触发。我将进一步讨论使用允许小胶质细胞特异性消耗的转基因小鼠的新数据,Cx3CR1-Cre ERT2 -eYFP;iDTR lox-STOP-lox(小胶质细胞cKO)。我们在外周损伤后的多个时间点进行了小胶质细胞清除,发现在损伤后几周进行清除时,男性和女性的机械异常性痛的减少最为显著。摘要:观察疼痛会给患者自身带来一系列的生理和心理反应,对于疼痛患者的照顾者和亲人来说,适应性管理这些反应的能力与提供适当的疼痛评估和疼痛管理行为的能力密切相关。这个由三部分组成的研讨会探讨了个人观察他们所爱的人在一生中经历一系列痛苦经历时的心理、生理和神经反应。研讨会将由疼痛科学家里德尔介绍他的个人反思,里德尔在帮助患有慢性疼痛的配偶方面有着丰富的经验。关于幼儿期生理心理次优行为的机制。摘要:随着对临床疼痛专家的需求不断增加,加拿大疼痛诊所的等待名单不断增加,有必要为患者找到创新的方法来获得管理疼痛和心理健康的支持。互联网为许多人提供了多个不同卫生领域的信息和治疗应用,随着2019冠状病毒病全球大流行,提供虚拟护理的需求从未像现在这样强烈。管理机构和患者群体对在线、自我指导的疼痛管理项目越来越感兴趣,其目标是向人们提供及时的干预,这些干预既基于证据,又易于理解。目前,加拿大正在为成人和儿童创建和测试基于互联网的多学科疼痛管理的各种选择。“战胜疼痛的力量”门户网站旨在为加拿大人提供快速访问基于经验的双语、阶梯式护理资源,以管理整个生命周期的疼痛、心理健康和物质使用。该门户网站提出的一个项目是基于互联网的多学科接受和承诺治疗(IMPACT)项目。摘要标题:可行性研究:通过IMPACT(基于互联网的多学科接受和承诺治疗)改善成年慢性疼痛患者获得疼痛干预的机会背景/目的获得疼痛诊所服务可能具有挑战性,长时间的等待名单延迟了患者接受任何形式的疼痛管理治疗。 我们试图创建和评估基于互联网的多学科疼痛接受和承诺治疗(IMPACT)计划,以解决疼痛服务中的这一差距。方法在患者伴侣的参与下,我们开发了一个基于接受和承诺疗法的多学科、在线、自我指导的疼痛管理项目。IMPACT课程内容包含多媒体和互动组件,包括视频、录音和反思性问题。一些项目视频由耐心的合作伙伴反映他们对项目主题的经历(例如,接受、价值观、承诺的行动)组成。该项目还包括与运动、药物、睡眠、沟通和人际关系相关的额外单元。我们对在加拿大温尼伯三级疼痛管理中心等待治疗的患者进行了可行性研究。参与者在进入项目前完成了基线测量,并在完成项目后立即和完成后6个月进行了随访。他们对整个课程的内容提供了反馈。结果71人同意参与,63人完成项目登记。参与者的平均年龄为55岁(23-83岁);76%被认定为女性。17名参与者完成了整个项目,27名参与者完成了随访。75%到100%的参与者推荐了他们完成的各个单元。将提供进一步的结果数据和项目反馈。根据研究结果,IMPACT项目在支持慢性疼痛患者方面显示出希望,包括那些可能无法及时获得疼痛专家服务的人。摘要:慢性疼痛是影响21%加拿大人口的公共卫生问题。摘要:2018年9月,卫生部长指示加拿大卫生部成立加拿大疼痛工作组,以帮助加拿大政府更好地了解和解决患有慢性疼痛的加拿大人的需求。在2019年3月至2021年5月期间,工作组审查了文献并进行了全国磋商,最终发表了三份报告,概述了加拿大在预防和管理慢性疼痛方面存在的差距、挑战和机遇。工作组于2021年5月发布的题为《加拿大疼痛行动计划》的最终报告为采取具体和有针对性的行动提供了一系列建议,以预防疼痛,改善慢性疼痛患者的健康结果,并解决其对家庭、社区和社会的影响。摘要:慢性疼痛的生物心理社会模型表明,除了生物因素外,还必须考虑心理和社会因素来理解个体的疼痛体验。因此,在制定最有效的治疗计划时,也应考虑这些因素。在本次研讨会上,Stone博士将首先简要总结当前对肌肉骨骼疼痛的生物学理解,重点介绍人类和动物研究中表观遗传驱动因素在慢性腰痛中的作用的新见解。由于表观遗传修饰是潜在可逆的,因此将强调其治疗意义。Massieh Moayedi博士将概述导致慢性疼痛的心理因素,并将介绍疼痛和认知之间相互作用的新数据,以及如何利用这些数据作为新的演讲者摘要题目:从患者的角度来看肌肉骨骼疼痛的社会驱动因素和后果Hovey博士在以患者为中心的护理和医疗保健沟通等领域弥合理论与实践之间的差距方面拥有专业知识。他的研究方法利用哲学解释学来加强我们对弱势群体和服务不足人群的理解,比如那些患有慢性疼痛和疾病、癌症、残疾或医学创伤的人。他还带来了作为一个在慢性疼痛中生活了10年的人的观点。学习目标1:整合关于腰痛分子驱动的新知识。学习目标2:解释疼痛如何竞争资源,以及疼痛管理的新潜在治疗靶点。学习目标3:从患者咨询师的角度描述疼痛的生活经验。摘要:在三级临床设置中,由集中转诊和分诊系统组成的单入口模式已显示出改善等待时间,减少重复转诊和防止取消预约的效果。多伦多学术疼痛医学研究所(TAPMI)是一个综合性的,跨学科的,三级疼痛计划在多伦多。 这是安大略省唯一一个成功实施慢性疼痛单入口系统的省级资助项目
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Canadian Journal of Pain-Revue Canadienne de la Douleur
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