Lancet Regional Health-Europe最新文献

{"title":"Rising antimicrobial resistance in Europe: EMA and ECDC outline urgent actions to achieve EU targets","authors":"Emer Cooke , Pamela Rendi-Wagner","doi":"10.1016/j.lanepe.2025.101539","DOIUrl":"10.1016/j.lanepe.2025.101539","url":null,"abstract":"","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"59 ","pages":"Article 101539"},"PeriodicalIF":13.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145693684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COP30: still failing to meet the challenge","authors":"The Lancet Regional Health – Europe","doi":"10.1016/j.lanepe.2025.101559","DOIUrl":"10.1016/j.lanepe.2025.101559","url":null,"abstract":"","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"59 ","pages":"Article 101559"},"PeriodicalIF":13.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145693798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Economic pressures threaten surgical quality in Germany: immediate policy action required","authors":"Stephan Schorn , Helmut Friess , Ihsan Ekin Demir","doi":"10.1016/j.lanepe.2025.101546","DOIUrl":"10.1016/j.lanepe.2025.101546","url":null,"abstract":"","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"59 ","pages":"Article 101546"},"PeriodicalIF":13.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145623530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"European Society for Medical Oncology (ESMO) congress 2025","authors":"Ivana Nedic","doi":"10.1016/j.lanepe.2025.101528","DOIUrl":"10.1016/j.lanepe.2025.101528","url":null,"abstract":"","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"59 ","pages":"Article 101528"},"PeriodicalIF":13.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145693797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular disease risk and the balance between animal-based and plant-based foods, nutritional quality, and food processing level in the French NutriNet-Santé cohort: a longitudinal observational study","authors":"Clémentine Prioux ,&nbsp;Emmanuelle Kesse-Guyot ,&nbsp;Bernard Srour ,&nbsp;Léopold K. Fézeu ,&nbsp;Julia Baudry ,&nbsp;Sandra Wagner ,&nbsp;Serge Hercberg ,&nbsp;Mathilde Touvier ,&nbsp;Benjamin Allès","doi":"10.1016/j.lanepe.2025.101470","DOIUrl":"10.1016/j.lanepe.2025.101470","url":null,"abstract":"<div><h3>Background</h3><div>Few studies have evaluated the effects of plant-based diets combined with ultra-processed food on cardiovascular diseases (CVD). The objective of this study was to assess associations between CVD risk and novel diet indices that integrate balance between plant-based and animal-based foods, nutritional quality and processing level.</div></div><div><h3>Methods</h3><div>We analyzed data from the French NutriNet-Santé prospective cohort. First, the two original healthy Plant-Based Diet and unhealthy Plant-Based Diet Indices (hPDI and uPDI) were computed. Four new indices were then built, based on the hPDI and uPDI computation, but with a multiplying factor to account for (i) the contribution of unprocessed food (UnPF) and (ii) the contribution of ultra-processed food (UPF), using the NOVA classification, culturally adapted. These two contributions (UnPF and UPF) were estimated using dietary data from 24 h records as percentages of total food consumed (g.day⁻¹). The association between each of the six resulting index scores and cardiovascular disease (cerebrovascular and coronary) was estimated using multivariate Cox proportional hazards models adjusted for confounding factors. Sensitivity analyses were also performed to assess the robustness of these novel indices.</div></div><div><h3>Findings</h3><div>Among 63,835 participants, median follow-up time 9.0 years, IQR: 5–13 years, 76% women, mean age 51.4, SD = 10.2, no statistically significant protective or deleterious association was observed between those adhering to a nutritionally healthy but ultra-processed plant-based diet (hPDI-UPF), and a nutritionally unhealthy but unprocessed plant-based diet (uPDI-UnPF). When comparing participants with the highest adherence to a nutritionally healthy and unprocessed plant-based diet (hPDI-UnPF), to those with the lowest, we observed a 44% lower incidence of coronary heart disease (HR_{D10 vs. D1}: 0.56, 95% CI: [0.42–0.75]) and 32% lower risk for CVD (HR_{D10 vs. D1}: 0.68, 95% CI: [0.53–0.88]). Similarly, participants with the highest adherence to an unhealthy and ultra-processed plant-based diet (uPDI-UPF) had a 46% higher incidence of coronary heart disease (HR_{D10 vs. D1}: 1.46, 95% CI: [1.11–1.93]), and a 38% higher incidence of CVD (HR_{D10 vs. D1}: 1.38, 95% CI: [1.09–1.76]). This was the strongest association observed in our study.</div></div><div><h3>Interpretation</h3><div>The findings of this study mark the importance of considering not only balance between plant-based and animal-based foods, but also nutritional quality and degree of processing when evaluating association between diet and cardiovascular risk.</div></div><div><h3>Funding</h3><div><span>French National Research Agency</span> (ANR, ANR-22-CE36-0012).</div></div>","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"59 ","pages":"Article 101470"},"PeriodicalIF":13.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145693682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to Diagnostic accuracy and predictive value of the QuantiFERON-TB gold plus assay for tuberculosis in immunocompromised individuals: a prospective TBnet study Lancet Reg Health Eur 57 (2025) 101416 LLRHEUROPE-D-25-00310","authors":"Martina Sester ,&nbsp;Neus Altet-Gomez ,&nbsp;Åse Bengaard Andersen ,&nbsp;Miguel Arias-Guillén ,&nbsp;Korkut Avsar ,&nbsp;Anne-Marte Bakken Kran ,&nbsp;Graham Bothamley ,&nbsp;Anne Christine Nordholm Breschel ,&nbsp;James Brown ,&nbsp;Dumitru Chesov ,&nbsp;Nelly Ciobanu ,&nbsp;Daniela Maria Cirillo ,&nbsp;Valeriu Crudu ,&nbsp;Malu de Souza Galvao ,&nbsp;Asli Görek Dilektasli ,&nbsp;José Dominguez ,&nbsp;Raquel Duarte ,&nbsp;Anne Ma Dyrhol-Riise ,&nbsp;Delia Goletti ,&nbsp;Harald Hoffmann ,&nbsp;Christoph Lange","doi":"10.1016/j.lanepe.2025.101523","DOIUrl":"10.1016/j.lanepe.2025.101523","url":null,"abstract":"","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"59 ","pages":"Article 101523"},"PeriodicalIF":13.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-COVID-19 condition in individuals infected with SARS-CoV-2 in autumn 2023 in the Netherlands: a prospective cohort study with pre- and post-infection data","authors":"Siméon de Bruijn ,&nbsp;Anne J. Huiberts ,&nbsp;Stijn P. Andeweg ,&nbsp;Christina E. Hoeve ,&nbsp;Maarten Schipper ,&nbsp;Diederick E. Grobbee ,&nbsp;Hester E. de Melker ,&nbsp;Janneke H.H.M. van de Wijgert ,&nbsp;Susan van den Hof ,&nbsp;Mirjam J. Knol ,&nbsp;Cees C. van den Wijngaard","doi":"10.1016/j.lanepe.2025.101472","DOIUrl":"10.1016/j.lanepe.2025.101472","url":null,"abstract":"<div><h3>Background</h3><div>Post-COVID-19 condition (PCC) risk may have changed due to vaccination status, virus variants, prior infections, and other factors. We aimed to estimate PCC prevalence for one year in individuals infected with SARS-CoV-2 during autumn 2023, controlling for pre-infection symptoms and prevalence in recently uninfected participants.</div></div><div><h3>Methods</h3><div>VASCO, a Dutch ongoing prospective cohort, collects three-monthly questionnaires and six-monthly SARS-CoV-2 serology. Participants indicated severity of 23 symptoms on a five-point Likert scale, and of fatigue and concentration problems on the Checklist Individual Strength. We matched participants who did with those who did not report a SARS-CoV-2 infection between September 25, 2023 and January 7, 2024, and censored follow-up time for both upon serological or antigen test evidence of infection. We estimated PCC-prevalence as the excess prevalence of at least one PCC-related symptom between matched infected and uninfected participants at 90, 180, 270, and 360 days post-infection. Additionally, participants could self-attribute long-term symptoms to SARS-CoV-2.</div></div><div><h3>Findings</h3><div>We 1:1 matched 5621 infected to 5621 uninfected participants. The PCC prevalence, estimated as the marginal mean excess prevalence of PCC-related symptoms between infected and uninfected participants, was 0.2% (95% confidence interval: −1.9 to 2.3, p = 0.84) at 90 days, 0.5% (−1.6 to 2.6, p = 0.63) at 180 days, 0.7% (−1.3 to 2.8, p = 0.48) at 270 days, and 0.0% (−2.1 to 2.1, p = 0.99) at 360 days. Excess prevalence of new mild and severe long-term symptoms self-attributed to SARS-CoV-2 between infected and uninfected participants were both elevated at 90 days (mild: 7.2% (5.1–9.2), severe: 0.6% (0.4–0.8)) and 180 days (mild: 3.2% (2.0–4.4), severe: 0.3% (0.2–0.4)) post-infection (all p-values &lt;0.0001), but no longer thereafter.</div></div><div><h3>Interpretation</h3><div>This double-controlled study, incorporating pre- versus post-infection and uninfected symptom data, found a low risk of PCC among a community-dwelling adult population infected during the autumn 2023 SARS-CoV-2 wave. The prevalence of PCC-related symptoms in infected and uninfected individuals was not significantly different at 90–360 days post-infection. The excess prevalences of self-attributed long-term symptoms were elevated at 90 and 180 days post-infection but no longer from 270 days onwards. These findings suggest that the 2023 wave inferred a lower PCC risk than during the pandemic period.</div></div><div><h3>Funding</h3><div>Funded by the <span>Dutch Ministry of Health, Welfare and Sport</span>.</div></div>","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"59 ","pages":"Article 101472"},"PeriodicalIF":13.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145693681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Now is the time: turning the promise of AI into health for all","authors":"Hans Henri P. Kluge,&nbsp;Natasha Azzopardi-Muscat,&nbsp;David Novillo-Ortiz","doi":"10.1016/j.lanepe.2025.101534","DOIUrl":"10.1016/j.lanepe.2025.101534","url":null,"abstract":"","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"59 ","pages":"Article 101534"},"PeriodicalIF":13.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145693683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating future variant Creutzfeldt-Jakob disease cases in the UK: a cohort-based probabilistic model","authors":"Barnaby Roberts ,&nbsp;James Riley ,&nbsp;Thomas J. Evans ,&nbsp;Richard Knight ,&nbsp;Jean Manson ,&nbsp;Graham Medley ,&nbsp;Manisha Upadhyay ,&nbsp;Katy Sinka ,&nbsp;Simon Mead","doi":"10.1016/j.lanepe.2025.101502","DOIUrl":"10.1016/j.lanepe.2025.101502","url":null,"abstract":"<div><h3>Background</h3><div>Variant Creutzfeldt–Jakob disease (vCJD) is a fatal prion disorder linked to dietary exposure to bovine spongiform encephalopathy (BSE). The epidemic peaked in the early 2000s, and no new cases have been reported in the UK since 2016. However, uncertainties remain regarding potential future cases, particularly in individuals with non-MM prion protein gene codon 129 genotypes, and possible secondary transmission via blood transfusion. We aimed to update risk estimates with recent data, informed by a probabilistic modelling approach.</div></div><div><h3>Methods</h3><div>We developed a cohort-based probabilistic model for variant CJD incidence incorporating genotype-specific attack rates and incubation periods, accounting for competing mortality risks. Model parameters were calibrated using historical case data and life-table analyses. We explored multiple scenarios, including sensitivity analyses with alternative incubation period distributions and potential missed diagnoses. Secondary transmission risk was assessed using historical transfusion-linked cases and epidemiological data.</div></div><div><h3>Findings</h3><div>In the base-case scenario, our model estimates a 48% probability that no further vCJD cases will occur, with a mean forecast of 2.7 additional cases. Allowing for missed past cases, estimates increased to a mean of 3.0 cases (one missed case) and 4.9 cases (four missed cases). Sensitivity analysis using a Cauchy incubation period distribution rather than a log-normal distribution increased estimates to 6.6, 9.4, and 17.9 cases, respectively. A plausible worse-case scenario, assuming very long incubation times and higher susceptibility in non-MM individuals, projected up to 65 cases of vCJD over coming decades, peaking in the 2030s. Secondary transmission risk remains negligible given transfusion safety measures, including leukodepletion since 1999.</div></div><div><h3>Interpretation</h3><div>Our findings suggest that vCJD is unlikely to re-emerge at significant levels. However, ongoing case ascertainment and scrutiny remains critical due to uncertainties in non-MM incubation and potentially, the emergence of previously unrecognised prion strains. Continued neuropathological case investigation, maintenance of core blood safety policies, and periodic risk reassessments are essential to ensure public health preparedness and avoid unnecessary restrictions.</div></div><div><h3>Funding</h3><div>No specific funding other than salaries of the authors.</div></div>","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"59 ","pages":"Article 101502"},"PeriodicalIF":13.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145693685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inequalities in all-cause mortality by ethnicity in the United Kingdom: a systematic review and meta-analysis","authors":"Fiona F. Stanaway ,&nbsp;Saman Khalatbari-Soltani ,&nbsp;Lin Zhu ,&nbsp;Thulashigan Sreeharan ,&nbsp;Naomi Noguchi ,&nbsp;Anupa Pathak ,&nbsp;Erin Mathieu ,&nbsp;Raj Bhopal","doi":"10.1016/j.lanepe.2025.101498","DOIUrl":"10.1016/j.lanepe.2025.101498","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Ethnic inequalities in health outcomes are a persistent concern in the United Kingdom (UK) and internationally. In this systematic review and meta-analysis, we aimed to quantify ethnic differences in all-cause mortality across the UK and explore the potential modifying roles of socioeconomic position (SEP) and country of birth.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;We searched Medline, Embase, Scopus, and Web of Science from inception to April 20, 2024, and identified grey literature via EThOS, ProQuest, Google, and data-sharing platforms. Eligible studies reported all-cause mortality by ethnicity or other commonly used measures such as country of birth or person or parents and surname in UK populations. Two reviewers independently conducted screening, data extraction, and risk of bias assessment using the ROBINS-E tool. Certainty of evidence was evaluated using GRADE. The review was registered with PROSPERO (CRD42019146143).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Findings&lt;/h3&gt;&lt;div&gt;Of 7672 records screened, 32 studies met inclusion criteria, supplemented by unpublished data from three cohort studies. Age-adjusted all-cause mortality was consistently lower among females of Bangladeshi (Relative Risk = 0.80, 95% CI 0.67–0.95), Indian (0.78, 0.68–0.88), Pakistani (0.85, 0.79–0.91), Black Caribbean (0.83, 0.81–0.85), Chinese (0.64, 0.61–0.69), and Mixed ethnicity (0.94, 0.90–0.98), and among males of Bangladeshi (0.89, 0.86–0.93), Indian (0.78, 0.69–0.88), Pakistani (0.76, 0.69–0.83), Black Caribbean (0.89, 0.85–0.93), and Chinese ethnicity (0.66, 0.50–0.87)), compared with White British individuals. In contrast, White Irish (1.20, 1.06–1.34) and White Scottish males (1.19, 1.11–1.27), and White Scottish females (1.18, 1.08–1.29), had higher mortality than other White British. Evidence on the role of SEP was inconclusive due to methodological heterogeneity. Evidence on the role of country of birth was also limited with wide and overlapping confidence intervals around the results stratified by country of birth (UK-born vs non-UK-born) in each ethnic group. However, the UK-born Black Caribbean population had higher relative mortality rate compared to the UK-born White British population (1.49; 0.98–2.28), although this did not quite reach statistical significance.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Interpretation&lt;/h3&gt;&lt;div&gt;Inequalities in mortality by ethnic group were consistent and substantial. The contribution of SEP to observed inequalities is complex and the quality of evidence is impacted by methodological heterogeneity. However, SEP disadvantage is unlikely to explain the lower relative mortality of non-white groups. The potential for inequalities within ethnic groups by country of birth has important policy implications, as this suggests the need to tailor public health strategies within ethnic groups by country of birth. However, more evidence is needed for most ethnic groups. As a result, we call for greater reporting of both ethnicity and country o","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"59 ","pages":"Article 101498"},"PeriodicalIF":13.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145693680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}