Pub Date : 2025-12-01DOI: 10.1016/j.lanepe.2025.101548
Hans Henri P. Kluge , Regina De Dominicis
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Pub Date : 2025-11-29DOI: 10.1016/j.lanepe.2025.101541
Jo Gibbs , Oliver Stirrup , Anna Tostevin , Alison Howarth , Claire Dewsnap , Jonathan D.C. Ross , Andy Williams , Vicky Tittle , Sara Day , Jack Brown , David Crundwell , Louise J. Jackson , Catherine H. Mercer , Jessica Sheringham , Ann Sullivan , Andrew J. Winter , Geoff Wong , Andrew Copas , Fiona Burns
<div><h3>Background</h3><div>A shift to online postal self-sampling (OPSS) for sexually transmitted infections (STIs) in high-income settings has occurred. We evaluate whether introduction of OPSS in England is associated with changes in testing activity and if this differs by population characteristics.</div></div><div><h3>Methods</h3><div>A retrospective study of sexual health (online and clinic-based) service-level data, across three case study areas (CSAs) that implemented OPSS at different times, using different models, and whose populations have different socio-demographic profiles, between 01/01/2015 and 31/12/2022 (from 01/08/2014 in CSA1 to ensure 12 months pre-OPSS). The primary outcome was chlamydia/gonorrhoea and HIV testing activity. We evaluated change over time using selected calendar years, with total activity following introduction of OPSS (2019 and 2022) compared to pre-OPSS periods (CSA1, 2014–2015, CSA2 2017, CSA3 2019), and whether outcome changes differed by socio-demographic characteristics.</div></div><div><h3>Findings</h3><div>In all CSAs chlamydia/gonorrhoea and HIV testing activity increased following introduction of OPSS with incidence rate ratios (IRR) for chlamydia/gonorrhoea testing in 2022 compared to pre-OPSS baseline ranging from 2.1 (95% CI 2.1–2.2) in CSA1 to 2.5 (95% CI 2.4–2.5) in CSA3, and for HIV testing from 1.5 (95% CI 1.5–1.5) in CSA1 to 2.8 (95% CI 2.8–2.8) in CSA2. Differences existed across all demographic characteristics in the relative change in testing incidence (all P < 0.0001 for chlamydia/gonorrhoea). Higher testing activity via OPSS was seen among men who have sex with men (MSM), particularly in CSAs1-2 for chlamydia/gonorrhoea (IRR2.9 (95% CI 2.8–3.1) and 3.6 (95% CI 3.5–3.7) in MSM compared to 1.7 (95% CI 1.7–1.8)and 1.8 (95% CI 1.8–1.8) in men who have sex exclusively with women (MSEW) for 2022 <em>vs</em> pre-OPSS). In CSA3, the largest relative increase occurred in women (IRR 3.2 (95% CI 3.1–3.3), compared to IRR 1.9 (95% CI 1.8–1.9) in MSEW). The most deprived areas had the lowest relative increase in chlamydia/gonorrhoea testing uptake (1.9–2.1 for CSA1-3).</div></div><div><h3>Interpretation</h3><div>Despite a reduction in clinic-based testing linked to COVID-19, the introduction of OPSS has been associated with increases in overall testing activity. OPSS uptake was lower among populations with greater potential for unmet need, such as individuals living in more deprived areas. Although OPSS is available to all people living within the commissioned areas, in practice not all individuals with a need for STI testing are aware of it or have the confidence and ability to access it. Differences across all socio-demographic characteristics in the relative change in testing could inadvertently increase existing inequalities in access to care and it is important to offer choice of mode of testing for service users.</div></div><div><h3>Funding</h3><div><span>National Institute for Health and C
在高收入环境中,性传播感染(STIs)已转向在线邮政自我抽样(OPSS)。我们评估了在英格兰引入OPSS是否与检测活动的变化有关,以及这种变化是否因人群特征而异。方法回顾性分析2015年1月1日至2022年12月31日(CSA1从2014年1月1日开始,以确保12个月前实施OPSS)三个案例研究区(CSA1)在不同时间、使用不同模型、人口具有不同社会人口特征的性健康(在线和基于诊所的)服务水平数据。主要结果是衣原体/淋病和艾滋病毒检测活动。我们使用选定的日历年评估随时间的变化,将引入OPSS(2019年和2022年)后的总活动与OPSS前时期(CSA1, 2014-2015年,CSA2 2017年,CSA3 2019年)进行比较,以及结果变化是否因社会人口特征而异。在所有csa中,引入OPSS后衣原体/淋病和艾滋病毒检测活动增加,与OPSS前基线相比,2022年衣原体/淋病检测的发病率比(IRR)从CSA1的2.1 (95% CI 2.1 - 2.2)到CSA3的2.5 (95% CI 2.4-2.5),艾滋病毒检测从CSA1的1.5 (95% CI 1.5 - 1.5)到CSA2的2.8 (95% CI 2.8 - 2.8)。在所有人口统计学特征中,检测发生率的相对变化都存在差异(衣原体/淋病的P均为0.0001)。通过OPSS在男男性行为者(MSM)中观察到较高的检测活性,特别是在CSAs1-2中对衣原体/淋病的检测(MSM的IRR2.9 (95% CI 2.8-3.1)和3.6 (95% CI 3.5-3.7),而2022年与OPSS前相比,专门与女性发生性行为的男性(MSEW)的IRR2.9 (95% CI 1.7 - 1.8)和1.8 (95% CI 1.8 - 1.8))。在CSA3中,女性的相对增加最大(IRR为3.2 (95% CI 3.1-3.3),而MSEW的IRR为1.9 (95% CI 1.8-1.9))。最贫困地区衣原体/淋病检测的相对增幅最低(CSA1-3为1.9-2.1)。尽管与COVID-19相关的临床检测减少了,但OPSS的引入与总体检测活动的增加有关。在未满足需求的潜力较大的人群中,例如生活在较贫困地区的个人,OPSS的吸收较低。虽然OPSS对居住在委托地区的所有人都是可用的,但实际上并不是所有需要性病检测的人都意识到这一点,或者有信心和能力获得它。在检测的相对变化中,所有社会人口特征之间的差异可能会无意中增加获得保健方面现有的不平等,因此为服务使用者提供检测模式的选择非常重要。资助国家健康和护理研究所。
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Pub Date : 2025-11-27DOI: 10.1016/j.lanepe.2025.101547
Laura M. Güdemann , Katherine G. Young , Pedro Cardoso , Bilal A. Mateen , Rury R. Holman , Naveed Sattar , Ewan R. Pearson , Andrew T. Hattersley , Angus G. Jones , Beverley M. Shields , John M. Dennis
Background
Routine clinical features of individual patients can potentially be used to guide selection of type 2 diabetes treatments. We aimed to evaluate a recently proposed treatment selection model predicting differences in glycaemic responses to SGLT2-inhibitors and DPP4-inhibitors across major UK ethnicity groups.
Methods
We externally validated the SGLT2i-DPP4i model in UK primary care cohort (CPRD Aurum, 2013–2020) independent of the original model development cohort. Non-insulin treated individuals with type 2 diabetes were identified and categorised by major UK self-reported ethnicity groups: White, Black, South Asian and Mixed/Other. For each ethnicity group, we applied a closed testing procedure to assess whether model recalibration was required. After model updates, we assessed the calibration accuracy of predicted differences in glycaemic response (6-month change in HbA1c) between SGLT2i and DPP4i for each ethnicity group.
Findings
SGLT2i (n = 57,749) and DPP4i (n = 87,807) initiations were identified amongst people of White (n = 114,287; 78.5%), Black (n = 6663; 4.6%), South Asian (n = 20,969; 14.4%) and Mixed/Other (n = 3637; 2.5%) ethnicities. Minor model adjustment was required to adjust for greater observed than predicted glycaemic responses to DPP4i (White—1.6 mmol/mol; Black—3.0 mmol/mol; South Asian—2.6 mmol/mol; Mixed/Other—2.6 mmol/mol). SGLT2i predictions did not require adjustment for non-White ethnicity groups. After model updates, average predicted HbA1c reduction was 3.7 mmol/mol (95% CI 3.5–3.9) greater with SGLT2i than DPP4i for those of White ethnicity; this was greater than for those of South Asian (2.1 mmol/mol (95% CI 1.6–2.6)), Black (0.6 mmol/mol (95% CI 0.5–1.7)) and Mixed/Other (2.6 mmol/mol (95% CI 1.4–3.8)) ethnicity groups. For all ethnicity groups, predicted differential glycaemic treatment effects were well calibrated.
Interpretation
Our model for selection of SGLT2-inhibitor and DPP4-inhibitor therapies was accurate for all major self-reported ethnicity groups in a UK primary care cohort. Simple recalibration is beneficial to optimise performance and this is recommended prior to deployment of the model in new populations and settings.
Funding
UK Medical Research Council, National Institute for Health and Care Research Exeter Biomedical Research Centre, and EFSD/Novo Nordisk.
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Pub Date : 2025-11-26DOI: 10.1016/j.lanepe.2025.101545
Rosemary Hiscock
{"title":"Promising measures for minimising e-cigarette youth uptake in countries with a significant e-cigarette market","authors":"Rosemary Hiscock","doi":"10.1016/j.lanepe.2025.101545","DOIUrl":"10.1016/j.lanepe.2025.101545","url":null,"abstract":"","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"60 ","pages":"Article 101545"},"PeriodicalIF":13.0,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145623614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-26DOI: 10.1016/j.lanepe.2025.101551
Sarah C. Clement , Hanneke M. van Santen
{"title":"Pediatric thyroid cancer in Europe: time to act and rethink care","authors":"Sarah C. Clement , Hanneke M. van Santen","doi":"10.1016/j.lanepe.2025.101551","DOIUrl":"10.1016/j.lanepe.2025.101551","url":null,"abstract":"","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"60 ","pages":"Article 101551"},"PeriodicalIF":13.0,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145623615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-25DOI: 10.1016/j.lanepe.2025.101543
Background
Detailed knowledge about the disease burden from unhealthy diet in Nordic and Baltic countries is lacking. This study quantifies and compares deaths and disability-adjusted life-years (DALYs) from dietary risks in these countries.
Methods
Data from the Global Burden of Disease study 2023 (GBD 2023) was used. Attributable disease burden from 15 dietary risks was analysed using the comparative risk assessment framework. Steps included: (1) estimating dietary intake; (2) assessing relative risks of dietary factors on disease endpoints; (3) determining theoretical minimum risk exposure levels (TMREL); and (4) estimating dietary risk-attributable disease burden as numbers and age-standardised rates (ASR) of deaths and DALYs.
Findings
Across the Nordic and Baltic countries (total population = 34,064,020), dietary risks resulted in 38,450 attributed deaths (95% uncertainty interval 10,749–59,386) and 735,284 DALYs (242,417–1,06,638) in 2023. Leading dietary risks included high intake of processed meat and low intake of fruits and whole grains. Dietary risks accounted for 24.9% of cardiovascular disease burden (5.0–37.6), 29.6% of diabetes and kidney disease burden (18.6–40.0), and 7.8% of neoplasm burden (2.9–12.1), with higher burden in the Baltic countries and Greenland than in the Nordic countries.
Interpretation
A substantial disease burden can be attributed to dietary risks in the Nordic and Baltic countries. Knowledge about the impact from unhealthy diet can inform targeted public health policies.
Funding
Gates Foundation and Norwegian Institute of Public Health.
{"title":"The burden of dietary risk factors in the Nordic and Baltic countries: a systematic analysis for the Global Burden of Disease Study 2023","authors":"","doi":"10.1016/j.lanepe.2025.101543","DOIUrl":"10.1016/j.lanepe.2025.101543","url":null,"abstract":"<div><h3>Background</h3><div>Detailed knowledge about the disease burden from unhealthy diet in Nordic and Baltic countries is lacking. This study quantifies and compares deaths and disability-adjusted life-years (DALYs) from dietary risks in these countries.</div></div><div><h3>Methods</h3><div>Data from the Global Burden of Disease study 2023 (GBD 2023) was used. Attributable disease burden from 15 dietary risks was analysed using the comparative risk assessment framework. Steps included: (1) estimating dietary intake; (2) assessing relative risks of dietary factors on disease endpoints; (3) determining theoretical minimum risk exposure levels (TMREL); and (4) estimating dietary risk-attributable disease burden as numbers and age-standardised rates (ASR) of deaths and DALYs.</div></div><div><h3>Findings</h3><div>Across the Nordic and Baltic countries (total population = 34,064,020), dietary risks resulted in 38,450 attributed deaths (95% uncertainty interval 10,749–59,386) and 735,284 DALYs (242,417–1,06,638) in 2023. Leading dietary risks included high intake of processed meat and low intake of fruits and whole grains. Dietary risks accounted for 24.9% of cardiovascular disease burden (5.0–37.6), 29.6% of diabetes and kidney disease burden (18.6–40.0), and 7.8% of neoplasm burden (2.9–12.1), with higher burden in the Baltic countries and Greenland than in the Nordic countries.</div></div><div><h3>Interpretation</h3><div>A substantial disease burden can be attributed to dietary risks in the Nordic and Baltic countries. Knowledge about the impact from unhealthy diet can inform targeted public health policies.</div></div><div><h3>Funding</h3><div><span>Gates Foundation and Norwegian Institute of Public Health</span>.</div></div>","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"61 ","pages":"Article 101543"},"PeriodicalIF":13.0,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-25DOI: 10.1016/j.lanepe.2025.101525
Iain Hardie , Louise Marryat , Aja Murray , Josiah King , Kenneth Okelo , Lynda Fenton , Abigail K. Stevely , James P. Boardman , Michael V. Lombardo , Sarah J. Stock , Rachael Wood , Bonnie Auyeung
Background
COVID-19 public health and social measures (PHSM) may have affected children's development, for example by reducing their interaction with others. We examined associations between PHSM and developmental concerns among young children in Scotland.
Methods
We utilised data from routine 13–15 month and 27–30 month child health reviews, covering all children in Scotland who took part in reviews between January 2019 and August 2023 and had full developmental data. Interrupted time-series analysis assessed slope changes in the weekly proportion of children with health visitor-identified developmental concerns following the March 2020 introduction of, and August 2021 removal of, PHSM. Outcomes were any 13–15 month and 27–30 month developmental concerns, and domain-specific concerns regarding speech-language-communication, problem solving, gross motor, personal-social, emotional-behavioural and fine motor development.
Findings
Weekly proportions were based on 257,532 children, covering 13–15 month review records for 186,265 children (95,506 [51.3%] male and 90,756 [48.7%] female) and 27–30 month review records for 186,766 children (95,209 [51.0%] male and 91,557 [49.0%] female). The March 2020 PHSM introduction was associated with a slope change increase in the proportion of children with any developmental concerns (+0.091 percentage points per week [95% CI: 0.065, 0.116] at 13–15 months and +0.076 percentage points per week [95% CI: 0.048, 0.104] at 27–30 months. The August 2021 PHSM removal was associated with a slope change decrease in the proportion of children with any developmental concerns at 27–30 months (−0.067 percentage points per week [95% CI: −0.088, −0.046]), but not 13–15 months, in the main analysis. Results were broadly consistent across developmental domains.
Interpretation
COVID-19 PHSM were associated with increased developmental concerns among young children in Scotland. While leveraging interrupted time-series analysis yields findings consistent with a causal impact of PHSM, the influence of potential time-varying confounders cannot be ruled out.
{"title":"COVID-19 public health and social measures (PHSM) and early childhood developmental concerns in Scotland: an interrupted time series analysis","authors":"Iain Hardie , Louise Marryat , Aja Murray , Josiah King , Kenneth Okelo , Lynda Fenton , Abigail K. Stevely , James P. Boardman , Michael V. Lombardo , Sarah J. Stock , Rachael Wood , Bonnie Auyeung","doi":"10.1016/j.lanepe.2025.101525","DOIUrl":"10.1016/j.lanepe.2025.101525","url":null,"abstract":"<div><h3>Background</h3><div>COVID-19 public health and social measures (PHSM) may have affected children's development, for example by reducing their interaction with others. We examined associations between PHSM and developmental concerns among young children in Scotland.</div></div><div><h3>Methods</h3><div>We utilised data from routine 13–15 month and 27–30 month child health reviews, covering all children in Scotland who took part in reviews between January 2019 and August 2023 and had full developmental data. Interrupted time-series analysis assessed slope changes in the weekly proportion of children with health visitor-identified developmental concerns following the March 2020 introduction of, and August 2021 removal of, PHSM. Outcomes were any 13–15 month and 27–30 month developmental concerns, and domain-specific concerns regarding speech-language-communication, problem solving, gross motor, personal-social, emotional-behavioural and fine motor development.</div></div><div><h3>Findings</h3><div>Weekly proportions were based on 257,532 children, covering 13–15 month review records for 186,265 children (95,506 [51.3%] male and 90,756 [48.7%] female) and 27–30 month review records for 186,766 children (95,209 [51.0%] male and 91,557 [49.0%] female). The March 2020 PHSM introduction was associated with a slope change increase in the proportion of children with any developmental concerns (+0.091 percentage points per week [95% CI: 0.065, 0.116] at 13–15 months and +0.076 percentage points per week [95% CI: 0.048, 0.104] at 27–30 months. The August 2021 PHSM removal was associated with a slope change decrease in the proportion of children with any developmental concerns at 27–30 months (−0.067 percentage points per week [95% CI: −0.088, −0.046]), but not 13–15 months, in the main analysis. Results were broadly consistent across developmental domains.</div></div><div><h3>Interpretation</h3><div>COVID-19 PHSM were associated with increased developmental concerns among young children in Scotland. While leveraging interrupted time-series analysis yields findings consistent with a causal impact of PHSM, the influence of potential time-varying confounders cannot be ruled out.</div></div><div><h3>Funding</h3><div>Economic and Social Research Council.</div></div>","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"60 ","pages":"Article 101525"},"PeriodicalIF":13.0,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145790203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-20DOI: 10.1016/j.lanepe.2025.101487
Massimo Agosti
{"title":"The NITAG debate in Italy: an opportunity for prevention","authors":"Massimo Agosti","doi":"10.1016/j.lanepe.2025.101487","DOIUrl":"10.1016/j.lanepe.2025.101487","url":null,"abstract":"","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"59 ","pages":"Article 101487"},"PeriodicalIF":13.0,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145579110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-20DOI: 10.1016/j.lanepe.2025.101535
Donal J. Buggy , Malachy O. Columb , Jeroen Hermanides , Markus W. Hollmann , Mark Coburn , Alexander Zarbock , MOPED Investigators
Background
The prevalence of people with Diabetes Mellitus (DM) presenting for surgery is increasing. Guidelines on perioperative management are based on expert opinion with variability of practice likely. Our objective was to document perioperative management and 30-day outcomes of people with DM across Europe.
Methods
This was a prospective, observational study involving 89 hospitals across 21 European countries, ranging from district general to tertiary referral centres. Between January 2021 and February 2024, 6126 people with confirmed DM (any type except gestational) receiving surgery of any kind requiring anaesthesia were followed for 30 days. Centres were self-selected by anaesthesiology clinicians working there, who enrolled consecutive people with DM to a locally determined target number. There was 5936 (97%) 30-day follow-up completion. The primary outcome was Days at Home at 30 Days (DAH-30). Secondary outcomes included descriptive characteristics of perioperative management, dysglycaemia and incidence of postoperative complications.
Findings
There was significant variation between countries in perioperative DM management and 30-day outcomes, and variance in DAH-30 (median [range]) 26 [23–30] days, P = 0.0001). The proportion of people with DM with increased HbA1c (>69 mmol mol) was higher in T1DM compared with T2DM (n = 51, 18% vs n = 388, 7%; difference 11%, 95% CI 6–17; P = 0.002). In univariate analysis, there was an association between patients with lower HbA1c < 53 mmol mol−1 median (25–75% range) DAH-30 = 27 days (23–29), contrasting with higher HbA1c > 69 mmol mol, median DAH-30 = 25 days (20–28); difference 2.0, 95% CI 1.3–2.7; P < 0.0001). This association was upheld in multivariable analysis only for patients with little blood loss.
Interpretation
There is a need to harmonise international practice to reduce variability in perioperative diabetes management and 30-day outcome.
Funding
The European Society of Anaesthesiology and Intensive Care (ESA-IC) funded administrative staff throughout the conduct of the study. The College of Anaesthesiologists of Ireland (CAI) and British Journal of Anaesthesia (BJA) partially contributed to data collection in Ireland and UK.
背景:糖尿病患者(DM)的手术患病率正在上升。围手术期管理指南基于专家意见,实践可能存在差异。我们的目标是记录整个欧洲糖尿病患者的围手术期管理和30天的结果。方法:这是一项前瞻性观察性研究,涉及21个欧洲国家的89家医院,从地区综合医院到三级转诊中心。在2021年1月至2024年2月期间,6126名确诊的糖尿病患者(除妊娠期外的任何类型)接受任何需要麻醉的手术,随访30天。中心由在那里工作的麻醉临床医生自行选择,他们连续招募DM患者到当地确定的目标数量。30天随访完成5936例(97%)。主要终点为30天在家天数(DAH-30)。次要结局包括围手术期处理、血糖异常和术后并发症发生率的描述性特征。研究结果:各国在围手术期DM管理和30天预后方面存在显著差异,在DAH-30(中位[范围])26[23-30]天方面存在显著差异,P = 0.0001。糖尿病患者HbA1c升高(69 mmol mol)的比例在T1DM患者中高于T2DM患者(n = 51,18% vs n = 388,7%;差异11%,95% CI 6-17; P = 0.002)。在单因素分析中,HbA1c≤53 mmol mol−1的患者中位(25 - 75%范围)DAH-30 = 27天(23-29),而HbA1c≤69 mmol mol的患者中位DAH-30 = 25天(20-28);差异2.0,95% CI 1.3 ~ 2.7;P < 0.0001)。在多变量分析中,这种关联仅在少量失血的患者中得到证实。有必要协调国际惯例,以减少围手术期糖尿病管理和30天预后的可变性。欧洲麻醉与重症监护学会(ESA-IC)在整个研究过程中为管理人员提供资金。爱尔兰麻醉师学院(CAI)和英国麻醉学杂志(BJA)为爱尔兰和英国的数据收集做出了部分贡献。
{"title":"Management and Outcomes of Perioperative Care of People with Diabetes across Europe (MOPED): a prospective, observational study","authors":"Donal J. Buggy , Malachy O. Columb , Jeroen Hermanides , Markus W. Hollmann , Mark Coburn , Alexander Zarbock , MOPED Investigators","doi":"10.1016/j.lanepe.2025.101535","DOIUrl":"10.1016/j.lanepe.2025.101535","url":null,"abstract":"<div><h3>Background</h3><div>The prevalence of people with Diabetes Mellitus (DM) presenting for surgery is increasing. Guidelines on perioperative management are based on expert opinion with variability of practice likely. Our objective was to document perioperative management and 30-day outcomes of people with DM across Europe.</div></div><div><h3>Methods</h3><div>This was a prospective, observational study involving 89 hospitals across 21 European countries, ranging from district general to tertiary referral centres. Between January 2021 and February 2024, 6126 people with confirmed DM (any type except gestational) receiving surgery of any kind requiring anaesthesia were followed for 30 days. Centres were self-selected by anaesthesiology clinicians working there, who enrolled consecutive people with DM to a locally determined target number. There was 5936 (97%) 30-day follow-up completion. The primary outcome was Days at Home at 30 Days (DAH-30). Secondary outcomes included descriptive characteristics of perioperative management, dysglycaemia and incidence of postoperative complications.</div></div><div><h3>Findings</h3><div>There was significant variation between countries in perioperative DM management and 30-day outcomes, and variance in DAH-30 (median [range]) 26 [23–30] days, P = 0.0001). The proportion of people with DM with increased HbA1c (>69 mmol mol) was higher in T1DM compared with T2DM (n = 51, 18% vs n = 388, 7%; difference 11%, 95% CI 6–17; P = 0.002). In univariate analysis, there was an association between patients with lower HbA1c < 53 mmol mol<sup>−1</sup> median (25–75% range) DAH-30 = 27 days (23–29), contrasting with higher HbA1c > 69 mmol mol, median DAH-30 = 25 days (20–28); difference 2.0, 95% CI 1.3–2.7; P < 0.0001). This association was upheld in multivariable analysis only for patients with little blood loss.</div></div><div><h3>Interpretation</h3><div>There is a need to harmonise international practice to reduce variability in perioperative diabetes management and 30-day outcome.</div></div><div><h3>Funding</h3><div>The <span>European Society of Anaesthesiology and Intensive Care</span> (ESA-IC) funded administrative staff throughout the conduct of the study. The <span>College of Anaesthesiologists of Ireland</span> (CAI) and <span>British Journal of Anaesthesia</span> (BJA) partially contributed to data collection in Ireland and UK.</div></div>","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"61 ","pages":"Article 101535"},"PeriodicalIF":13.0,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145580502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-20DOI: 10.1016/j.lanepe.2025.101538
Xavier Chapalain , Olivier Huet , Kathryn M. Rowan , Paul R. Mouncey , Olivier Langeron , David K. Menon , David A. Harrison
Background
Recent epidemiological studies reported conflicting results regarding mortality trends for traumatic brain injury (TBI) patients. Mortality trends for the critically ill TBI population, and their drivers of changes, remains understudied. Particularly, withdrawal of life-sustaining therapy (WLST) decisions were rarely evaluated concurrently. In this study, we aimed to describe hospital mortality and WLST trends over the past 15 years in England, Wales and Northern Ireland for TBI patients admitted to an intensive care unit (ICU).
Methods
Observational cohort study, involving 235 adult ICUs participating in the Intensive Care National Audit & Research Centre (ICNARC) Case Mix Programme (CMP). From April 1, 2009 to March 31, 2024, all TBI patients were included. Comparator cohorts consisted of patients with trauma, sepsis, and vascular brain injury recorded in the CMP. The primary outcome was hospital mortality. The secondary outcome was the incidence of WLST decisions. We also examined the proportion of patients experiencing predefined early secondary brain insults.
Findings
Of the 2,324,961 ICU admissions, we identified 45,684 unique TBI patients. Over the study period, hospital mortality for TBI patients increased from 25.6% (1021/3988) to 35.0% (1306/3727). The proportion of WLST decisions rose from 7.5% (301/4024) to 19.7% (759/3850). After adjustment for main confounders, multivariable analyses confirmed these trends. No similar trends were observed among the comparator cohorts. TBI patients were exposed to hypotension, hypocapnia, hypercapnia and hyperglycaemia in 49.8% (22,559/45,298), 29.9% (12,356/41,262), 33.6% (13,869/41,262) and 29.2% (12,127/41,505) of cases, respectively. Half of patients (50.3%, 20,747/41,265) were exposed to hypoxaemia, and this proportion increased markedly from 36.9% (1359/3684) to 61.2% (2186/3572) over time.
Interpretation
For critically ill TBI patients, hospital mortality and WLST decisions rates increased over time. These findings raise important questions regarding the processes and ethical frameworks underpinning WLST decisions.
Funding
UKRI, NIHR, UK Ministry of Defence, Alzheimer’s Research UK, French Society of Anaesthesiology and Critical Care, Gueules Cassées Foundation, INNOVEO donation fund.
{"title":"Hospital mortality, withdrawal of life-sustaining therapy decisions and early secondary brain insults for critically ill traumatic brain injury patients in England, Wales and Northern Ireland (2009–2024): an observational cohort study","authors":"Xavier Chapalain , Olivier Huet , Kathryn M. Rowan , Paul R. Mouncey , Olivier Langeron , David K. Menon , David A. Harrison","doi":"10.1016/j.lanepe.2025.101538","DOIUrl":"10.1016/j.lanepe.2025.101538","url":null,"abstract":"<div><h3>Background</h3><div>Recent epidemiological studies reported conflicting results regarding mortality trends for traumatic brain injury (TBI) patients. Mortality trends for the critically ill TBI population, and their drivers of changes, remains understudied. Particularly, withdrawal of life-sustaining therapy (WLST) decisions were rarely evaluated concurrently. In this study, we aimed to describe hospital mortality and WLST trends over the past 15 years in England, Wales and Northern Ireland for TBI patients admitted to an intensive care unit (ICU).</div></div><div><h3>Methods</h3><div>Observational cohort study, involving 235 adult ICUs participating in the Intensive Care National Audit & Research Centre (ICNARC) Case Mix Programme (CMP). From April 1, 2009 to March 31, 2024, all TBI patients were included. Comparator cohorts consisted of patients with trauma, sepsis, and vascular brain injury recorded in the CMP. The primary outcome was hospital mortality. The secondary outcome was the incidence of WLST decisions. We also examined the proportion of patients experiencing predefined early secondary brain insults.</div></div><div><h3>Findings</h3><div>Of the 2,324,961 ICU admissions, we identified 45,684 unique TBI patients. Over the study period, hospital mortality for TBI patients increased from 25.6% (1021/3988) to 35.0% (1306/3727). The proportion of WLST decisions rose from 7.5% (301/4024) to 19.7% (759/3850). After adjustment for main confounders, multivariable analyses confirmed these trends. No similar trends were observed among the comparator cohorts. TBI patients were exposed to hypotension, hypocapnia, hypercapnia and hyperglycaemia in 49.8% (22,559/45,298), 29.9% (12,356/41,262), 33.6% (13,869/41,262) and 29.2% (12,127/41,505) of cases, respectively. Half of patients (50.3%, 20,747/41,265) were exposed to hypoxaemia, and this proportion increased markedly from 36.9% (1359/3684) to 61.2% (2186/3572) over time.</div></div><div><h3>Interpretation</h3><div>For critically ill TBI patients, hospital mortality and WLST decisions rates increased over time. These findings raise important questions regarding the processes and ethical frameworks underpinning WLST decisions.</div></div><div><h3>Funding</h3><div><span>UKRI</span>, <span>NIHR</span>, <span>UK Ministry of Defence</span>, <span>Alzheimer’s Research</span> UK, <span>French Society of Anaesthesiology and Critical Care</span>, <span>Gueules Cassées Foundation</span>, <span>INNOVEO donation fund</span>.</div></div>","PeriodicalId":53223,"journal":{"name":"Lancet Regional Health-Europe","volume":"61 ","pages":"Article 101538"},"PeriodicalIF":13.0,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145580501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}