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The Effectiveness of Pharmacist-Led Medication Review in Petaling District Health Office 花瓣陵区卫生办事处药师主导的用药审查效果分析
Pub Date : 2021-11-23 DOI: 10.21315/mjps2021.19.2.7
Wan Maisarah Wan Ahmad Kamal, Lee Mee Chan, Zakiah Abas, Darishini Murugiah, Goh Yen Joe, Nadhrah Rasyidah Ramli, Lui Park Yeang, Abdullah Azim Zulkafli, Wong Keng Wei
Medication review is an important service in optimising medicine use and improves clinical outcomes. This study aims to assess the effectiveness of pharmacist-led medication review on patients’ knowledge and adherence. For this prospective study, 480 patients were randomly recruited in six primary healthcare clinics in Petaling District Health Office. Patients were interviewed with a questionnaire and validated medication adherence scale during recruitment and at follow-up visit to assess their medication knowledge and adherence. The data was analysed using Chi-square tests and paired t-tests to determine the correlation between medication knowledge and adherence with patient demographics. Among 408 patients that had completed the follow-up, 16.9% of patients showed medication knowledge deficits on recruitment. However, there is a significant improvement in the medication knowledge indices during the follow-up session (p < 0.001). Elderly patients were found to benefit from medication review with better medication knowledge and adherence postmedication review. The study found that the number of good adherers increased by 29.3% after the medication review. A further study demonstrating the effectiveness of medication review in cultivating knowledge retention and sustained adherence in the longer-term is warranted. Future work shall also focus on measuring the cost-effectiveness of pharmacistled medication review implementation in primary healthcare settings. Pharmacist-led medication review is an essential and effective service in primary health care facilities for patients to enhance their knowledge on their medications, and adherence especially in elderly patients on chronic medications.
药物审评是优化药物使用和提高临床疗效的重要服务。本研究旨在评估药师主导的药物审查对患者知识和依从性的有效性。在这项前瞻性研究中,在八打岭区卫生办事处的六个初级卫生保健诊所随机招募了480名患者。在招募和随访时对患者进行问卷调查和验证的药物依从性量表,以评估其药物知识和依从性。使用卡方检验和配对t检验对数据进行分析,以确定药物知识和依从性与患者人口统计学之间的相关性。在408例完成随访的患者中,16.9%的患者在招募时存在用药知识缺陷。然而,在随访期间,用药知识指标有显著改善(p < 0.001)。老年患者的用药知识和服药后复查依从性较好,受益于用药复查。研究发现,在药物审查后,良好的依从者数量增加了29.3%。一项进一步的研究证明了药物审查在培养知识保留和长期持续依从性方面的有效性是必要的。未来的工作还应侧重于衡量初级卫生保健环境中药典药物审查实施的成本效益。在初级卫生保健机构中,药师主导的药物审查是一项重要而有效的服务,可提高患者对药物的认识,并提高对慢性药物治疗的依从性,尤其是老年患者。
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引用次数: 0
A Multicentre Study on Average Warfarin Dose to Maintain Therapeutic International Normalised Ratio with Time in Therapeutic Range of More than 75% in Atrial Fibrillation Patients 心房颤动患者平均华法林剂量维持治疗国际标准化比率的多中心研究
Pub Date : 2021-11-23 DOI: 10.21315/mjps2021.19.2.3
Ang Kee Hooi, Ishmah Musfirah Nazari, Low Seow Huey, Ng Yinwen, Oon Xin Ying, Valliyamai A/P Suppiah
Large interindividual variability and over-anticoagulation resulting bleeding complications due to narrow therapeutic index of warfarin has causes its pharmacodynamic activity to be highly variable. Studies shown that ethnicity, age and gender contribute to warfarin response variability. Good coagulation control of time in therapeutic range (TTR) > 75% was chosen to determine the average warfarin dose in atrial fibrillation (AF) among ethnicity, age and gender. Data from Warfarin Medication Therapy Adherence Clinic of selected Pulau Pinang hospitals were used for the analysis of average warfarin dose in AF among ethnicity, age and gender. Patients who fulfilled the inclusion criteria from 2015–2016 were followed up for a year. Five hundred and seventy-six patients were included. Two hundred and ten patients had good coagulation control of TTR > 75% with mean warfarin dose of 3.05 ± 1.25 mg. Only Chinese and Indian have significant difference in average warfarin dose with 2.86 ± 1.10 mg and 4.11 ± 1.40 mg, respectively (p = 0.008). Average warfarin dose was found not significantly different among gender and age. As for TTR achievement, 210 (36.4%) were able to achieve TTR > 75%, 134 patients achieved TTR 60%–75% and 232 patients has TTR < 60%. The median day to achieve three consecutive targeted international normalised ratio (INR) is 186.5 days for atrial fibrillation patient newly started on warfarin therapy in 2015 until 2016. Indian patients required a higher warfarin dose than Chinese patients. This study found that mean warfarin doses were not affected by age and sex.
由于华法林治疗指数狭窄,个体间变异性大,抗凝过度导致出血并发症,导致其药效学活性高度可变。研究表明,种族、年龄和性别会导致华法林反应的变异性。选择治疗范围(TTR)>75%的良好凝血控制时间来确定不同种族、年龄和性别的心房颤动(AF)患者的平均华法林剂量。来自选定的皮昂岛医院华法林药物治疗依从性诊所的数据用于分析不同种族、年龄和性别的AF患者的平均华法林剂量。对2015-2016年符合纳入标准的患者进行了一年的随访。其中包括五百七十六名患者。210名患者的TTR>75%的凝血控制良好,平均华法林剂量为3.05±1.25 mg。只有中国和印度的平均华法林·剂量有显著差异,分别为2.86±1.10 mg和4.11±1.40 mg(p=0.008)。发现不同性别和年龄的平均华法林剂量没有显著差异。就TTR成绩而言,210名(36.4%)患者的TTR>75%,134名患者的TTR达到60%-75%,232名患者的TTPR<60%。对于2015年至2016年新开始接受华法林治疗的心房颤动患者,实现连续三次目标国际标准化比值(INR)的中位天数为186.5天。印度患者需要的华法林剂量高于中国患者。这项研究发现,华法林的平均剂量不受年龄和性别的影响。
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引用次数: 0
Development of Gas Chromatography-Mass Spectrometry Fingerprints for Warburgia Ugandensis Herbal Materials 气相色谱-质谱指纹图谱的建立
Pub Date : 2021-11-23 DOI: 10.21315/mjps2021.19.2.2
Onyambu Meshack O, Gikonyo Nicholas K, Nyambaka Hudson N, Thoithi Grace N, Okumu Tom O
Warbugia ugandensis (W. ugandensis) is among the 10 most utilised medicinal plants in East Africa. Stem bark and leaves are used as remedies for malaria, stomachache, coughs and skin diseases. Consequently, the plant is endangered because of uncontrolled harvest and lack of domestication. There is therefore fear of poor quality commercialised products due to lack of evaluation mechanisms. This study explored the chemical profiles that could be used to confirm its authenticity and purity. W. ugandensis used as reference during method development was harvested from Kenyatta University Medicinal Plant Research Garden (KUMPRG). Six other samples were obtained from different geographical locations in Kenya. The samples were identified by a botanist and a voucher specimen (MO/002- 008/2013) deposited in the East African Herbarium, National Museums of Kenya, Nairobi. Samples were harvested and processed by World Health Organization (WHO) recommended methods. Chromatographic profiles of the leaf and stem bark were established based on parameters arrived at iteratively. The study characterised over 100 compounds in the leaf and stem bark. Based on area percent and known medicinal value, 22 compounds from the leaf and 38 from the stem bark were selected as major chemical profiles. The compounds in the stem bark included gamma-sitosterol (1.0%–2.5%), squalene (0.2%–4.6%), isolongifolene (1.2%–2.8%), phenol 2-methoxy (0.8%–1.8%) and nerolidol (0.3%–1.5%). Those in the leaf included nerolidol 2 (0.3%–1.1%), phytol (0.6%–1.7%), 2-methoxy phenol (0.2%– 2.2%), gamma-tocopherol (0.2%–0.9%), vitamin E (0.4%–1.5%) and gamma-sitosterol (1.8%–4.9%). Most of these compounds were characterised in W. ugandensis for the first time. The profiles therefore can form fingerprints for use to evaluate its quality, purity and authenticity.
乌干达瓦布贾(W. ugandensis)是东非利用最多的10种药用植物之一。茎的树皮和叶子被用来治疗疟疾、胃痛、咳嗽和皮肤病。因此,由于不受控制的收获和缺乏驯化,这种植物濒临灭绝。因此,由于缺乏评估机制,人们担心会出现质量低劣的商业化产品。本研究探索了可用于确认其真实性和纯度的化学特征。在方法开发过程中作为参考的乌干达白杨采自肯雅塔大学药用植物研究花园(KUMPRG)。另外六个样本是从肯尼亚不同的地理位置获得的。这些标本由一位植物学家鉴定,并存放于内罗毕肯尼亚国家博物馆东非植物标本室的代金券标本(MO/002- 008/2013)。采集样品并按照世界卫生组织(世卫组织)推荐的方法进行处理。根据迭代得到的参数,建立了叶和茎皮的色谱图谱。该研究鉴定了叶子和茎皮中超过100种化合物。根据面积百分比和已知药用价值,从叶中选择22种化合物,从茎皮中选择38种化合物作为主要化学成分。茎皮中含有γ -谷甾醇(1.0% ~ 2.5%)、角鲨烯(0.2% ~ 4.6%)、异长叶烯(1.2% ~ 2.8%)、酚2-甲氧基(0.8% ~ 1.8%)和橙花醇(0.3% ~ 1.5%)。叶中含有橙花醇2(0.3% ~ 1.1%)、叶绿醇(0.6% ~ 1.7%)、2-甲氧基酚(0.2% ~ 2.2%)、γ -生育酚(0.2% ~ 0.9%)、维生素E(0.4% ~ 1.5%)和γ -谷甾醇(1.8% ~ 4.9%)。其中大部分化合物均为首次从乌干达白檀中分离得到。因此,这些轮廓可以形成指纹,用于评估其质量,纯度和真实性。
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引用次数: 0
Drug-Related Problems in Emergency Department Visits and Intensive Care Units at Healthcare Facilities in Saudi Arabia: A Review of the Literature 沙特阿拉伯医疗机构急诊科就诊和重症监护室中的药物相关问题:文献综述
Pub Date : 2021-11-23 DOI: 10.21315/mjps2021.19.2.10
O. Alshargi, A. Jatau, A. Sha’aban
The burden of drug-related problems (DRPs) is becoming an issue of healthcare concern. It has been responsible for many intensive care unit (ICU) admissions and emergency department (ED) visits in Saudi Arabia. We aim to summarise available data on ED visits and ICU admissions linked to DRPs in Saudi Arabia and provide recommendations for preventive measures. A systematic search of the literature was conducted using PubMed and Google Scholar databases to identify eligible studies. The review included research on ED visits and ICU admissions linked to DRPs performed in Saudi Arabia from the database’s inception to January 2020. Study selection, data extraction and assessment were performed based on the Preferred Reporting Items for Systematic Review and MetaAnalysis (PRISMA) guidelines. The initial search of literature generated 267 articles. After the study selection, 15 articles met our eligibility criteria and were included in the review. The commonly implicated DRPs were adverse drug reactions, medication non-adherence, drug overdose and drug interactions. Central nervous system drugs and cardiovascular drugs were the most frequently involved drugs. Most of these visits resulted in moderate harm. The prevalence of DRPs associated with ED visits and ICU admissions is high in Saudi Arabia. Sixteen out of a hundred ED visits and ICU admissions are related to DRPs. Therefore, the Saudi government should implement interventions to improve the awareness of rational drug use in the general public.
药物相关问题(DRP)的负担正成为医疗保健关注的问题。它负责沙特阿拉伯的许多重症监护室(ICU)入院和急诊科(ED)就诊。我们旨在总结沙特阿拉伯与DRP相关的ED就诊和ICU入院的可用数据,并提供预防措施建议。使用PubMed和Google Scholar数据库对文献进行了系统搜索,以确定符合条件的研究。该综述包括从数据库成立到2020年1月在沙特阿拉伯进行的与DRP相关的ED就诊和ICU入院研究。研究选择、数据提取和评估是根据系统评价和荟萃分析的首选报告项目(PRISMA)指南进行的。最初的文献检索产生了267篇文章。经过研究筛选,有15篇文章符合我们的资格标准,并被纳入审查。通常涉及的DRP是药物不良反应、药物不依从性、药物过量和药物相互作用。中枢神经系统药物和心血管药物是最常见的药物。这些探访大多造成中度伤害。在沙特阿拉伯,与ED就诊和ICU入院相关的DRP患病率很高。百分之十六的急诊就诊和ICU入院与DRP有关。因此,沙特政府应采取干预措施,提高公众合理用药的意识。
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引用次数: 3
In Vitro Biopharmaceutical and Physicochemical Evaluation of Different Brands of Ciprofloxacin Marketed in Aden-Yemen 也门亚丁市售不同品牌环丙沙星的体外生物制药和理化评价
Pub Date : 2021-11-23 DOI: 10.21315/mjps2021.19.2.5
Wafa F Badulla, Dua’a H Al-Maqdi, Ebtesam S Bamahmood
The current study conducted to evaluate the biopharmaceutical and physicochemical equivalence of the three available pharmaceutical dosage forms of ciprofloxacin (CIP) in the local markets (tablets, infusion and eye drops). Three brands for each dosage form were selected and coded as Tablets I, II, III; CIP infusion (Infusion I, II, III) and CIP eye drops (Eye drops I, II, III). Different in vitro quality control tests, physiochemical and determination of active ingredients contents were performed. All brands of tablets have a satisfactory result that complies with the pharmacopeia specification except the hardness of the tablets was more than the recommended value, and the salinity of Infusion II and III was lower than 0.9, the viscosity of the eye drops was lower than the specified value. Post-marketing surveillance is an essential issue to distinguish poor-quality medicines and must be routinely performed to weed out substandard and counterfeit medicine.
目前进行的研究旨在评估当地市场上三种可用的环丙沙星(CIP)药物剂型(片剂、输液剂和滴眼液)的生物制药和物理化学等效性。每种剂型选择三个牌号,编号为片号I、II、III;CIP输液剂(输液I、II、III)和CIP滴眼液(滴眼液I、II、III)进行不同的体外质控试验、理化及有效成分含量测定。所有品牌的片剂除片剂硬度大于推荐值、输液ⅱ、输液ⅲ矿化度低于0.9、滴眼液粘度低于规定值外,均符合药典规范。上市后监测是区分劣质药品的一个重要问题,必须定期进行监测以淘汰不合格药品和假药。
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引用次数: 0
Effect of Genetic Modification of Maize Plant on Pharmaceutically Important Properties of Its Starch 玉米植物基因改造对其淀粉重要药用特性的影响
Pub Date : 2021-11-23 DOI: 10.21315/mjps2021.19.2.4
L. Bakre, O. Olayemi, Aderinsola Dupe Adegbesan, Oluyemisi Adebowale Bamiro, O. Kunle
Genetic engineering of maize plants for improved yield, drought and pest resistance has received considerable attention in agricultural research. The aim of this work is to determine the effect of genetic modification of maize plant on some pharmaceutically relevant fundamental properties of its isolated starches. Properties of starches isolated from PVA 39 and IWD 15 maize genotypes were compared with starch from unmodified maize grains. Morphology studied by scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC) were evaluated. Swelling capacity, amylose content, pasting behaviour of the starches were also determined. SEM revealed that all the starches are largely irregular and polygonal with few round shaped granules. FTIR showed identical peaks in all the starch samples and DSC revealed higher enthalpies of starch gelatinisation from the modified grains. Modification also increased amylose content, swelling capacity and viscosity of the starches. Genetic modification increased amylose content which positively affected pharmaceutically important properties like moisture sorption and viscosity, thus, increasing their value in formulations especially as binders.
利用玉米基因工程提高产量、抗旱性和抗病虫害能力已成为农业研究的热点。这项工作的目的是确定转基因玉米植物对其分离淀粉的一些药学相关的基本性质的影响。比较了从PVA 39和IWD 15玉米基因型中分离得到的淀粉的特性。通过扫描电镜(SEM)、傅里叶变换红外光谱(FTIR)和差示扫描量热法(DSC)对其形貌进行了评价。还测定了淀粉的膨胀能力、直链淀粉含量和糊化行为。扫描电镜显示,淀粉大部分呈不规则和多角形,有少量圆形颗粒。FTIR在所有淀粉样品中显示相同的峰,DSC显示改性颗粒的淀粉糊化焓更高。改性还提高了淀粉的直链淀粉含量、膨胀能力和粘度。基因改造增加了直链淀粉的含量,这对诸如吸湿性和粘度等药学上重要的特性产生了积极的影响,从而增加了它们在配方中的价值,特别是作为粘合剂。
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引用次数: 0
Relationship Marketing Practices in Community Pharmacies in Nigeria 尼日利亚社区药房的关系营销实践
Pub Date : 2020-11-30 DOI: 10.21315/mjps2020.18.2.3
Ihekoronye Romanus Maduabuchi, Osemene Kanayo Patrick, Erhun Oyekigho Wilson
The study identified the types of relationship marketing (RM) practices, determined thecomponents of RM that fostered customer loyalty (CL) and evaluated the influence ofthe RM components on CL in community pharmacies. It was a cross-sectional surveyof community pharmacies, pharmacists, non-pharmacist staff and customers. Randomsampling was employed to select 40 community pharmacies, while purposive samplingwas used to select four staff from each of the community pharmacies (160). Accidentalsampling was used to select 510 customers of the pharmacies. Data were obtained withthe questionnaire and analysed using appropriate descriptive and inferential statistics.Social RM practices yielded optimal results. The RM components that were determinedwere trust (TR), commitment (CMT), competence (CP), communication (CM), conflicthandling (CH) and accessibility, which accounted for 55.4% of the total variance thatoccurred in CL. All the components of RM had positive but significant influence on CLwith varying magnitudes. The study revealed that the types of RM practices in community pharmacies were the giving of loyalty gifts to customers, personalised telephone CMs, calling customers by name and special greeting codes. Also, special discounts and credits were offered to certain customers in order to build relationships. All the RM components positively influenced CL. Easy A to the pharmacies and pharmacists proved to be most influential in building loyalty followed by CM. The study concluded that RM practices in community pharmacies hold a lot of promise for community pharmacies to sustain their existing customers.
本研究确定了关系营销(RM)实践的类型,确定了关系营销中培养顾客忠诚度(CL)的组成部分,并评估了社区药房关系营销各组成部分对顾客忠诚度的影响。这是一项针对社区药房、药剂师、非药剂师员工和顾客的横断面调查。采用随机抽样的方法抽取40家社区药房,采用有目的抽样的方法从每家社区药房抽取4名工作人员(160名)。随机抽样法选取510名药店顾客。通过问卷调查获得数据,并使用适当的描述性和推断性统计进行分析。社会RM实践产生了最佳结果。被确定的风险管理成分为信任(TR)、承诺(CMT)、能力(CP)、沟通(CM)、冲突处理(CH)和可及性,占风险管理总方差的55.4%。RM各成分对cl1均有不同程度的显著正影响。研究表明,社区药房的RM实践类型是向顾客赠送忠诚礼物、个性化电话CMs、直呼顾客的名字和特殊的问候代码。此外,为了建立关系,还向某些客户提供特别折扣和积分。RM各成分对CL均有正向影响。Easy A对药店和药剂师的忠诚度影响最大,其次是CM。该研究的结论是,社区药房的RM实践对社区药房维持现有客户有很大的承诺。
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引用次数: 0
A CROSS-SECTIONAL ASSESSMENT OF SHARED-DECISION MAKING AMONG PATIENTS VISITING PUBLIC HEALTHCARE INSTITUTE OF QUETTA CITY, PAKISTAN 对巴基斯坦奎达市公立医疗机构就诊患者共同决策情况的横断面评估
Pub Date : 2020-05-31 DOI: 10.21315/mjps2020.18.1.2
H. Waheed, S. Haider, Q. Iqbal, A. Khalid, M. Hassali, M. Bashaar, F. Saleem
HIRA WAHEED1, SAJJAD HAIDER1, QAISER IQBAL1, ADNAN KHALID2, MOHAMED AZMI HASSALI3, MOHAMMAD BASHAAR4 AND FAHAD SALEEM1* 1Faculty of Pharmacy & Health Sciences, University of Balochistan, Quetta, Pakistan 2Combined Military Hospital, Quetta, Pakistan 3School of Pharmaceutical Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysia 4Health Policy Analyst, SMART Afghan International Trainings & Consultancy, Afghanistan
HIRA WAHEED1, SAJJAD HAIDER1, QAISER IQBAL1, ADNAN KHALID2, MOHAMED AZMI HASSALI3, MOHAMMAD BASHAAR4 AND FAHAD SALEEM1* 1Faculty of Pharmacy & Health Sciences, University of Balochistan, Quetta、2Combined Military Hospital, Quetta, Pakistan 3School of Pharmaceutical Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysia 4Health Policy Analyst, SMART Afghan International Trainings & Consultancy, Afghanistan
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引用次数: 0
A Cross Sectional Assessment of Shared Decision among Patients Visiting Public Healthcare Institute of Quetta City, Pakistan 巴基斯坦奎达市公共卫生保健研究所患者共同决策的横断面评估
Pub Date : 2020-05-25 DOI: 10.5530/amdhs.2020.1.1
H. Waheed, S. Haider, F. Saleem, Rabia Ishaq, Muhammad Anwar, Q. Iqbal
Background: Shared decision making, occasionally called “participatory governance” is the approach in healthcare to ensure that patients have the right to participate effectively in the decision making (DM) process. Aim: The aim of this research was to discuss the external aspect of SDM and put forward applicable solutions to ensure SDM at both patient and physician levels. Methods: A standardized validated nine-item Shared Decision Making Questionnaire (patient version SDM-Q-9) was employed. SPSS version 25 used to perform data analysis. Multiple tests such as Mann Whitney U and Johnkheere-Terpstra were used. Kendall’s Tau was used for interpretation of the significant relationship among all items of SDM-Q9 and education. Results: A total of 465 chronically ill patients took part, where majority (63.4%) of patients was above the age of 47. The cohort was dominated by females (67.5%). 92% of the sample was married. Majority (86.9%) of the patient reported not involved in any decision. During analysis considerable association was reported between gender and all items of SDM-Q9, where more men were involved in SDM when compared with women. Our findings did produce significant association between education and SDM-Q9, which reveals that increase in education, can improve the SDM. Conclusion: Shared decision making shouldn’t be limited to chronic or emergency in practice. Specific and tailored shared medical decision making programs must be developed for low literacy population implementation. SDM is to be supported at policy and operation levels.
背景:共享决策,有时被称为“参与式治理”,是医疗保健中确保患者有权有效参与决策(DM)过程的方法。目的:本研究的目的是讨论SDM的外部方面,并提出适用的解决方案,以确保患者和医生层面的SDM。方法:采用标准化、经验证的共有9项决策问卷(患者版SDM-Q-9)。使用SPSS 25版进行数据分析。使用了Mann Whitney U和Johnkheere-Terpstra等多种测试。采用Kendall 's Tau解释SDM-Q9各条目与教育之间的显著关系。结果:共纳入465例慢性疾病患者,其中47岁以上患者占63.4%。该队列以女性为主(67.5%)。92%的调查对象已婚。大多数(86.9%)的患者报告没有参与任何决定。在分析过程中,性别与SDM- q9的所有项目之间存在相当大的关联,与女性相比,男性更多地参与SDM。我们的研究结果确实产生了教育与SDM- q9之间的显著关联,这表明教育的增加可以改善SDM。结论:在实践中,共同决策不应局限于慢性或紧急情况。必须为低识字率人口制定具体和量身定制的共享医疗决策方案。SDM将在政策和操作层面得到支持。
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引用次数: 0
期刊
Malaysian Journal of Pharmaceutical Sciences
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