Pub Date : 2023-01-01DOI: 10.14300/mnnc.2023.18068
Petr Mikhailovich Maslyukov, Valentina Vyacheslavovna Porseva, Polina Aleksandrovna Anfimova, Lidiya Georgievna Pankrasheva, Andrey Anatolyevich Baranov, Nikolay Yurievich Levshin, Konstantin Yurievich Moiseev
{"title":"Influences of intrahypothalamic administration of microrna inhibitors and mimetics on blood plasma biomarkers with aging of the rat","authors":"Petr Mikhailovich Maslyukov, Valentina Vyacheslavovna Porseva, Polina Aleksandrovna Anfimova, Lidiya Georgievna Pankrasheva, Andrey Anatolyevich Baranov, Nikolay Yurievich Levshin, Konstantin Yurievich Moiseev","doi":"10.14300/mnnc.2023.18068","DOIUrl":"https://doi.org/10.14300/mnnc.2023.18068","url":null,"abstract":"","PeriodicalId":53493,"journal":{"name":"Medical News of North Caucasus","volume":"2016 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135908486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.14300/mnnc.2023.18039
A. Korobkeev, Evgeniya Alysheva, A. Khodzhayan, Oxana Lezhnina
{"title":"Аngioarchitectonics of the subepicardial vascular bed of the heart on the lateral surface of the left ventricle in young adulthood","authors":"A. Korobkeev, Evgeniya Alysheva, A. Khodzhayan, Oxana Lezhnina","doi":"10.14300/mnnc.2023.18039","DOIUrl":"https://doi.org/10.14300/mnnc.2023.18039","url":null,"abstract":"","PeriodicalId":53493,"journal":{"name":"Medical News of North Caucasus","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66996196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.14300/mnnc.2023.18002
Anna Yuryevna Ryabova, I. Kozlova, T. G. Shapovalova, Mikhailovna Shashina Marina, Anastasia Sergeevna Shiryaeva
{"title":"Features of cardiac remodeling in patients with frequent exacerbations of severe COPD and in its combination with arterial hypertension","authors":"Anna Yuryevna Ryabova, I. Kozlova, T. G. Shapovalova, Mikhailovna Shashina Marina, Anastasia Sergeevna Shiryaeva","doi":"10.14300/mnnc.2023.18002","DOIUrl":"https://doi.org/10.14300/mnnc.2023.18002","url":null,"abstract":"","PeriodicalId":53493,"journal":{"name":"Medical News of North Caucasus","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66994776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.14300/mnnc.2023.18021
A. Kade, P. P. Polyakov, S. A. Zanin, E. S. Zanina
{"title":"Modern ideas about the etiology and pathogenesis of hereditary hemorrhagic telangiectasia","authors":"A. Kade, P. P. Polyakov, S. A. Zanin, E. S. Zanina","doi":"10.14300/mnnc.2023.18021","DOIUrl":"https://doi.org/10.14300/mnnc.2023.18021","url":null,"abstract":"","PeriodicalId":53493,"journal":{"name":"Medical News of North Caucasus","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66995924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.14300/mnnc.2023.18006
M. N. Belokopytova, V. Baturin, I. Dolgova, S. Karpov
{"title":"Immunological predictors of cognitive impairment in patients with type 2 diabetes mellitus","authors":"M. N. Belokopytova, V. Baturin, I. Dolgova, S. Karpov","doi":"10.14300/mnnc.2023.18006","DOIUrl":"https://doi.org/10.14300/mnnc.2023.18006","url":null,"abstract":"","PeriodicalId":53493,"journal":{"name":"Medical News of North Caucasus","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66995391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.14300/mnnc.2023.18028
A. Yagoda, P. Koroy, Elena Otarievna Demurcheva, Nikolay Evgenyevich Hvatalin, Anna Daniilovna Svetogurova, V. Sarithala
Ninety patients with type 2 diabetes mellitus (DM) aged 39 to 76 years were examined. Women were 71 (78.9 %), men – 19 (21.1 %). The diagnosis of non-alcoholic fatty liver disease (NAFLD) was made based on an ultrasound examination of the abdominal cavity. The levels of vitamin D in the blood were determined by enzyme immunoassay. NAFLD was detected in 66.7 % of patients with type 2 DM. Vitamin D levels in the blood of patients with NAFLD on the background of type 2 DM were lower, and its deficiency was more common than in cases of DM without NAFLD. Serum vitamin D levels in patients with NAFLD and cholestatic syndrome were lower than in cases of NAFLD without signs of cholestasis. According to regression analysis, the development of NAFLD in type 2 DM is affected by reduced vitamin D levels in the blood and increased values of glucose, alanine aminotransferase, and low-density lipoproteins. Thus, the development of NAFLD against the background of type 2 DM is associated with a decrease in vitamin D concentration in the blood. Serum level of vitamin D less than 16.18 ng/ml can be used as a predictor of NAFLD in patients with type 2 DM.
{"title":"Vitamin D as a marker of non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus","authors":"A. Yagoda, P. Koroy, Elena Otarievna Demurcheva, Nikolay Evgenyevich Hvatalin, Anna Daniilovna Svetogurova, V. Sarithala","doi":"10.14300/mnnc.2023.18028","DOIUrl":"https://doi.org/10.14300/mnnc.2023.18028","url":null,"abstract":"Ninety patients with type 2 diabetes mellitus (DM) aged 39 to 76 years were examined. Women were 71 (78.9 %), men – 19 (21.1 %). The diagnosis of non-alcoholic fatty liver disease (NAFLD) was made based on an ultrasound examination of the abdominal cavity. The levels of vitamin D in the blood were determined by enzyme immunoassay. NAFLD was detected in 66.7 % of patients with type 2 DM. Vitamin D levels in the blood of patients with NAFLD on the background of type 2 DM were lower, and its deficiency was more common than in cases of DM without NAFLD. Serum vitamin D levels in patients with NAFLD and cholestatic syndrome were lower than in cases of NAFLD without signs of cholestasis. According to regression analysis, the development of NAFLD in type 2 DM is affected by reduced vitamin D levels in the blood and increased values of glucose, alanine aminotransferase, and low-density lipoproteins. Thus, the development of NAFLD against the background of type 2 DM is associated with a decrease in vitamin D concentration in the blood. Serum level of vitamin D less than 16.18 ng/ml can be used as a predictor of NAFLD in patients with type 2 DM.","PeriodicalId":53493,"journal":{"name":"Medical News of North Caucasus","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66996004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.14300/mnnc.2023.18053
M. Petrosyan, N. Verisokina, L. Klimov, V. Kuryaninova, R. Atanesyan, O.S. Kirienko
Improvements in neonatal care for premature babies have led to significant improvements in survival rates for low and very low birth weight infants. Due to the characteristics of calcium-phosphorus homeostasis and bone metabolism, neonatologists often encounter skeletal system pathology in premature newborns. This condition is a metabolic disease of premature infants’ bones based on a deficiency of calcium, phosphorus, and vitamin D, resulting in impaired growth and mineralization of the growing skeleton. Vitamin D is one of the most important regulators of bone metabolism. On the one hand, it stimulates the absorption of Ca2+ and P3-in the small intestine, and on the other hand, it has a direct effect on bone tissue cells (osteoblasts, osteocytes, osteoclasts, and chondrocytes) through the vitamin D receptors located in them. Risk factors for developing bone metabolism disorders in term and premature newborns, as well as the correlating role of vitamin D in skeletal formation and maintaining homeostasis, were considered.
{"title":"The significance of vitamin D in the regulation of bone metabolism in term and premature infants","authors":"M. Petrosyan, N. Verisokina, L. Klimov, V. Kuryaninova, R. Atanesyan, O.S. Kirienko","doi":"10.14300/mnnc.2023.18053","DOIUrl":"https://doi.org/10.14300/mnnc.2023.18053","url":null,"abstract":"Improvements in neonatal care for premature babies have led to significant improvements in survival rates for low and very low birth weight infants. Due to the characteristics of calcium-phosphorus homeostasis and bone metabolism, neonatologists often encounter skeletal system pathology in premature newborns. This condition is a metabolic disease of premature infants’ bones based on a deficiency of calcium, phosphorus, and vitamin D, resulting in impaired growth and mineralization of the growing skeleton. Vitamin D is one of the most important regulators of bone metabolism. On the one hand, it stimulates the absorption of Ca2+ and P3-in the small intestine, and on the other hand, it has a direct effect on bone tissue cells (osteoblasts, osteocytes, osteoclasts, and chondrocytes) through the vitamin D receptors located in them. Risk factors for developing bone metabolism disorders in term and premature newborns, as well as the correlating role of vitamin D in skeletal formation and maintaining homeostasis, were considered.","PeriodicalId":53493,"journal":{"name":"Medical News of North Caucasus","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66996327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diverticulum of the right half of the colon. A case report","authors":"Andrey Sergeevich Gorbunov, Fedor Petrovich Vetshev, Sergey Petrovich Vetshev, Yulia Vladimirovna Lerner, Radmila Vladimirovna Karpova, Natalya Vasilievna Petukhova, Ksenia Sergeevna Ruskova, Daria Viktorovna Momatyuk","doi":"10.14300/mnnc.2023.18075","DOIUrl":"https://doi.org/10.14300/mnnc.2023.18075","url":null,"abstract":"","PeriodicalId":53493,"journal":{"name":"Medical News of North Caucasus","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135908488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.14300/mnnc.2023.18007
O. Bobrysheva, S. Pisarenko, D. Kovalev, E. Eremenko, A. Ryazanova, Olga Viktorovna Semenova, D. V. Ulshina, A. Kulichenko
genomic sequences from the international GenBank database were used. As a result of genetic analysis, it was found that the strains isolated in 1957 and 1963 belong to the main genetic line B, branch B.Br.002 and have a high degree of genetic relationship with strains from Western Siberia, which indicates their common origin. Isolates distinguished in 2019 belong to the TEA Br.008/011 group, A.Br.118 branch. These strains form a separate branch and are closely related to the «STI» clade. The data obtained can be used in the differentiation of strains during the investigation of outbreaks of anthrax.
{"title":"Phylogenetic analysis of Bacillus anthracis strains isolated in the Republic of Dagestan","authors":"O. Bobrysheva, S. Pisarenko, D. Kovalev, E. Eremenko, A. Ryazanova, Olga Viktorovna Semenova, D. V. Ulshina, A. Kulichenko","doi":"10.14300/mnnc.2023.18007","DOIUrl":"https://doi.org/10.14300/mnnc.2023.18007","url":null,"abstract":"genomic sequences from the international GenBank database were used. As a result of genetic analysis, it was found that the strains isolated in 1957 and 1963 belong to the main genetic line B, branch B.Br.002 and have a high degree of genetic relationship with strains from Western Siberia, which indicates their common origin. Isolates distinguished in 2019 belong to the TEA Br.008/011 group, A.Br.118 branch. These strains form a separate branch and are closely related to the «STI» clade. The data obtained can be used in the differentiation of strains during the investigation of outbreaks of anthrax.","PeriodicalId":53493,"journal":{"name":"Medical News of North Caucasus","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66995502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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