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Treatment Process of Primary Prostate Leiomyosarcoma: A Rare Case Report. 原发性前列腺平滑肌肉瘤的治疗过程:一罕见病例报告。
Q3 Medicine Pub Date : 2023-05-01
Denis Cetin, Mustafa Murat Mıdık, Mustafa Mustafayev, Burcak Karaca

Prostate sarcoma is an extremely rare malignancy that accounts for only %0.1 of all neoplasms of the prostate gland. Primary prostate leiomyosarcoma (PLSOP) is the most common subtype in adults. Due to the fact that it is an extremely rare malignancy, case reports have been reported frequently and several publications in the form of case series. The number of case reports in the world is less than 200. Our opinion is that publishing such rare diseases and bringing them to the literature will have positive benefits both scientifically and for the patients. We present a patient with PLSOP and discuss the clinical, diagnostic and therapeutic aspects of this rare malignancy. Keywords: Prostate, Leiomyosarcoma, Cancer, Prognosis.

前列腺肉瘤是一种极为罕见的恶性肿瘤,仅占所有前列腺肿瘤的% 0.1%。原发性前列腺平滑肌肉瘤(PLSOP)是成人中最常见的亚型。由于它是一种极其罕见的恶性肿瘤,病例报告经常被报道,并以病例系列的形式发表。全世界报告的病例数不到200例。我们的观点是,发表这些罕见疾病并将其纳入文献将对科学和患者都有积极的好处。我们报告了一例PLSOP患者,并讨论了这种罕见恶性肿瘤的临床、诊断和治疗方面。关键词:前列腺,平滑肌肉瘤,肿瘤,预后
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引用次数: 0
Identification of the Physiological Dimension and SelfConcept among Husbands of Iranian Women with Mastectomy; a Directed Content Analysis. 伊朗女性乳房切除术后丈夫生理维度和自我概念的认同定向内容分析。
Q3 Medicine Pub Date : 2023-05-01
Marzieh Beigom Bigdeli Shamloo, Nasrin Elahi, Marziyeh Asadi Zaker, Kourosh Zarea, Armin Zareiyan

Background: Breast cancer, as the most prevalent cancer among females, exerts physical and mental impacts on both patients and their husbands. The present study aimed at investigating various dimensions of self-concept among husbands of Iranian women with mastectomy.

Methods: This study was conducted on 23 patients with mastectomy and their husbands and therapists using directed content analysis according to Callista-Roy adaptation model. The participants were interviewed regarding how they coped with cancer through video call, and 'physical dimensions' and 'self-concept' subcategories were identified. Content analysis was done using the Elo and Kyngus approach.

Results: The results revealed two main themes, namely 'exposure to physical challenges' and 'weakened to strengthened self-concept'.

Discussion and conclusion: This research showed the existence of many physical and mental problems of women undergoing mastectomy, and it is recommended to do interventions to reduce these complications.

背景:乳腺癌是女性中最常见的癌症,对患者及其丈夫都会产生身体和精神上的影响。本研究旨在调查伊朗乳房切除术妇女的丈夫自我概念的各个维度。方法:采用Callista-Roy适应模型对23例乳房切除术患者及其丈夫、治疗师进行定向内容分析。参与者通过视频电话接受了关于他们如何应对癌症的采访,并确定了“身体尺寸”和“自我概念”的子类别。内容分析使用Elo和Kyngus方法完成。结果:结果揭示了两个主要主题,即“暴露于身体挑战”和“自我概念从减弱到增强”。讨论与结论:本研究显示乳房切除术妇女存在许多身心问题,建议采取干预措施减少这些并发症。
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引用次数: 0
Tumor-Stroma Ratio in ER+/HER2- Breast Cancer: Is it a Tool for Treatment Decision? ER+/HER2-乳腺癌的肿瘤间质比:是治疗决策的工具吗?
Q3 Medicine Pub Date : 2023-05-01
Choukri Elmhadi, Mohammed Allaoui, Meryem Zerrik, Mohammed Oukabli, Rachid Tanz, Mohammed Ichou

Purpose: The primary aim of this study is to determine the relationship between tumor-stroma ratio (TSR) and traditional prognostic factors in luminal early breast cancer in women treated at the medical oncology department of the military hospital of Rabat in Morocco.

Methods: A retrospective study was performed on primary invasive ER+/HER2- breast cancer in the period from January 1st, 2019 to December 31st, 2019. Prognostic factors included age, tumour size, lymph nodes status, Scarff-Bloom-Richardson grading, lymphovascular invasion (LVI), Ki67 and the stage of the disease. The type of Adjuvant systemic therapy was also reported .Two independent pathologists have assessed TSR by microscopic evaluation of haematoxylin and eosin tumor slides .Patients with less than 50% stroma were classified as low-stroma, the others are classified as high-stroma.

Results: Of 53 ER+/HER2- operable breast cancer, 41.5% patients had low-stroma and 58.5% patients had high stroma-tumour. High stroma was significantly associated with more stage III (p=0.041), more LVI (0.034), high Ki-67 (p=0.002) and more luminal B disease (p=0.001). Also, high stroma received more adjuvant chemotherapy (p=0.005). The results are maintained in univariate analysis.

Conclusions: Data suggest that TSR can be used to guide decisions on adjuvant systemic therapy for ER+/HER2- breast cancer. The integration in routine of this simple and reproducible parameter requires a homogenization of the techniques as well as a prospective validation.

目的:本研究的主要目的是确定在摩洛哥拉巴特军事医院内科肿瘤科治疗的妇女腔内早期乳腺癌的肿瘤基质比(TSR)与传统预后因素之间的关系。方法:对2019年1月1日至2019年12月31日的原发性浸润性ER+/HER2-乳腺癌进行回顾性研究。预后因素包括年龄、肿瘤大小、淋巴结状况、Scarff-Bloom-Richardson分级、淋巴血管侵袭(LVI)、Ki67和疾病分期。两名独立的病理学家通过显微镜下对血红素和伊红肿瘤切片的评估来评估TSR。基质小于50%的患者被分类为低基质,其余的被分类为高基质。结果:53例ER+/HER2可手术乳腺癌中,41.5%为低基质瘤,58.5%为高基质瘤。高间质与更多的III期(p=0.041)、更多的LVI(0.034)、高Ki-67 (p=0.002)和更多的腔内B疾病(p=0.001)显著相关。同时,高基质患者接受的辅助化疗较多(p=0.005)。结果在单变量分析中得到维持。结论:数据表明,TSR可用于指导ER+/HER2-乳腺癌辅助全身治疗的决策。这一简单和可重复参数的常规整合需要技术的均质化以及前瞻性验证。
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引用次数: 0
Does the Nightmare of Distressing Complications of Groin Dissection Over with "River Flow" Incision? - Experience of 240 Dissections from Tertiary Referral Oncology Centre, India. 腹股沟剥离“河流”切口并发症的噩梦结束了吗?-印度三级转诊肿瘤中心240例解剖的经验。
Q3 Medicine Pub Date : 2023-05-01
M D Ray, J R Jeena Josephin, Premanand N

Objective: Groin dissection has been a nightmare for many surgeons due to its higher morbidity especially flap necrosis. Various modifications in incisions have been described in the literature to reduce the complications but with variable outcomes. By our novel "River Flow" incision technique, we have significantly reduced the procedure related complications without compromising onco surgical principles.

Methods: A prospective longitudinal clinical observational study was designed after Institutional Ethical Committee clearance, aiming to minimize the rate of complications, especially flap necrosis. All patients who underwent unilateral/bilateral ilio-inguinal block dissection (IIBD) from January 2014 to December 2021 were included in the study. The "River Flow" incision was made and standard ilio-inguinal block dissection was performed. Flap viability, seroma formation, lymphedema, infection, etc. were observed and noted during hospitalization and on followup. Clavien- Dindo classification was used to grade the postoperative complications. We have taken our historical data of 235 groin dissections as a control and compared them with the results of the present study. It is one of the largest studies on groin dissection so far.

Results: A total of 138 patients underwent 240 groin dissections. The most common diagnosis was carcinoma penis (44.9%) followed by carcinoma vulva (22.4%). Overall, the outcome of all groin dissections showed no postoperative mortality. None of the patients had complete flap necrosis. But in our historical data, the flap necrosis rate was 38%. The most common complication observed was seroma formation in 13.7% of cases followed by surgical site infection (6.52%). All the complications were managed conservatively. The postoperative stay of the patients was also significantly less. The median hospital stay was 3 days.

Conclusion: "River Flow" incision technique is a simple but effective novel surgical technique for therapeutic ILND for any surgical setup without the learning curve. It can avoid flap necrosis, and decrease morbidity significantly without compromising the onco surgical principle of standard groin dissection.

Key words: Groin dissection, skin necrosis, river flow incision.

目的:腹股沟剥离术因其较高的发病率,尤其是皮瓣坏死,一直是许多外科医生的噩梦。文献中描述了各种切口的修改以减少并发症,但结果不一。通过我们新颖的“河流”切口技术,我们在不损害肿瘤手术原则的情况下显著减少了手术相关并发症。方法:经机构伦理委员会批准,设计一项前瞻性纵向临床观察研究,旨在减少并发症,特别是皮瓣坏死的发生率。2014年1月至2021年12月,所有接受单侧/双侧髂-腹股沟阻滞夹层(IIBD)手术的患者均被纳入研究。切开“河流”切口,进行标准的髂-腹股沟阻滞解剖。住院及随访期间观察并记录皮瓣活力、血肿形成、淋巴水肿、感染等情况。术后并发症采用Clavien- Dindo分级。我们以235例腹股沟夹层的历史数据作为对照,并将其与本研究的结果进行比较。这是迄今为止最大规模的腹股沟解剖研究之一。结果:138例患者共行240例腹股沟切除术。最常见的诊断是阴茎癌(44.9%),其次是外阴癌(22.4%)。总的来说,所有腹股沟解剖的结果显示没有术后死亡率。所有患者均无皮瓣完全坏死。但在我们的历史数据中,皮瓣坏死率为38%。最常见的并发症是血肿形成(13.7%),其次是手术部位感染(6.52%)。所有并发症均予保守处理。患者术后住院时间明显缩短。平均住院时间为3天。结论:“河流”切口技术是一种简单而有效的新型手术技术,适用于任何手术设置,无需学习曲线。它可以避免皮瓣坏死,在不影响标准腹股沟夹层手术原则的情况下显著降低发病率。关键词:腹股沟剥离,皮肤坏死,河流切口。
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引用次数: 0
Prevalence of BRCA1 and BRCA2 Mutations Among High-risk Bahraini Patients with Breast Cancer. 巴林高危乳腺癌患者BRCA1和BRCA2突变的患病率
Q3 Medicine Pub Date : 2023-05-01
Zain Bukamal, Amal AlRayes

Objective: The purpose is to study the prevalence of BRCA1 and BRCA2 mutations in high-risk Bahraini patients diagnosed with breast cancer, its relation to family history, and to determine the clinicopathologic features of breast cancer associated with these genetic mutations, over a period of 7 years.

Background: Breast cancer is the most common type of cancer occurring in women and the second most common type generally. Approximately 12% of women worldwide will develop carcinoma of the breast sometime during their life. Additionally, 72% of women with an inherited BRCA1 mutation and 69% of those with a mutated BRCA2 will develop breast cancer by 80 years of age. The incidence of breast cancer in Bahraini women have increased over the last decade. Still, the data on BRCA1 & BRCA2 mutations in relation to breast cancer patients is limited in the Arab region, not omitting Bahrain as a country with deficient BRCA prevalence data.

Methods: This retrospective study was carried out in Salmaniya Medical Complex, Bahrain, to determine the prevalence of BRCA1 and BRCA2 mutations and to observe the breast cancer's histopathologic features that are associated with these mutations.

Results: 271 patients underwent the BRCA gene testing between 2013 and 2019. Out of 271 patients, 35 were excluded. Out of the 236 breast cancer patients, 219 (93%) did not have the mutation. The BRCA gene was carried by a total of 17 (7%) patients; 13 (5%) BRCA1 and 4 (2%) BRCA2. Thirteen BRCA carrier patients had invasive ductal carcinoma (IDC) (76%), 2 had ductal carcinoma in situ (DCIS) (12%), while 2 patients' histopathology was not available. Molecular subtypes showed 4 triple negative basal sub-type (TNBC), 10 positive ER and PR hormonal status, 1 positive HER-2, while 2 patients' hormonal receptor status was not available. Two BRCA1 carriers had both breast and ovarian cancers. A total of 5 (2%) breast cancer male patients were among the tested population, out of which, 1 (0.4% of the total and 20% of the male patients) was a BRCA2 carrier. Out of the 236 patients, 76 (32%) were younger than 40 years of age at the time of diagnosis. Then again, out of the 17 BRCA carrier patients, 7 (41%) were younger than 40 years.

Conclusion: The prevalence of BRCA mutation in high risk Bahraini breast cancer patients is 7%. Among those patients, BRCA1 mutation is the most prevalent (5%) and invasive ductal carcinoma (IDC) is the most common histopathological subtype. However, there was not enough data to conclude the most prevalent molecular subtype of breast cancer in BRCA carriers due to deficiency of overseas pathology reports for patients operated outside Bahrain. When developing treatment plans for younger patients with breast cancer, inherited syndromes and precisely BRCA mutations need to be considered. Bahrain is implementing genetic testing for breast cancer patients

目的:研究巴林高危乳腺癌患者BRCA1和BRCA2突变的患病率及其与家族史的关系,确定与这些基因突变相关的乳腺癌的临床病理特征,研究时间为7年。背景:乳腺癌是女性中最常见的癌症类型,也是第二常见的癌症类型。全世界大约有12%的女性会在一生中的某个时候患上乳腺癌。此外,72%携带BRCA1基因突变的女性和69%携带BRCA2基因突变的女性在80岁之前会患上乳腺癌。巴林妇女的乳腺癌发病率在过去十年中有所增加。尽管如此,BRCA1和BRCA2突变与乳腺癌患者相关的数据在阿拉伯地区是有限的,巴林也是一个缺乏BRCA患病率数据的国家。方法:本回顾性研究在巴林Salmaniya Medical Complex进行,以确定BRCA1和BRCA2突变的患病率,并观察与这些突变相关的乳腺癌组织病理学特征。结果:2013年至2019年期间,271名患者接受了BRCA基因检测。271例患者中,35例被排除在外。在236例乳腺癌患者中,219例(93%)没有这种突变。共有17例(7%)患者携带BRCA基因;13例(5%)BRCA1, 4例(2%)BRCA2。BRCA携带者有浸润性导管癌(invasive ductal carcinoma, IDC) 13例(76%),导管原位癌(ductal carcinoma in situ, DCIS) 2例(12%),2例组织病理资料未知。分子亚型显示4例三阴性基底亚型(TNBC), 10例ER和PR激素状态阳性,1例HER-2阳性,2例激素受体状态不详。两名BRCA1携带者同时患有乳腺癌和卵巢癌。在测试人群中,共有5名(2%)男性乳腺癌患者,其中1名(占总数的0.4%,占男性患者的20%)是BRCA2携带者。在236例患者中,76例(32%)在诊断时年龄小于40岁。然后,在17例BRCA携带者中,7例(41%)年龄小于40岁。结论:巴林高危乳腺癌患者BRCA突变发生率为7%。在这些患者中,BRCA1突变最为普遍(5%),浸润性导管癌(invasive ductal carcinoma, IDC)是最常见的组织病理学亚型。然而,由于缺乏在巴林境外手术的患者的海外病理报告,没有足够的数据来推断BRCA携带者中最常见的乳腺癌分子亚型。在为年轻乳腺癌患者制定治疗计划时,需要考虑遗传综合征和BRCA突变。根据NCCN指南,巴林自2018年起对≤50岁的乳腺癌患者实施基因检测。我们将继续建立我们的数据库,以更好地表征乳腺癌亚型,并确定其遗传模式,以识别巴林的高风险家庭,并为未来开发更具体的治疗方法。关键词:乳腺癌,BRCA1, BRCA2, BRCA突变,巴林,阿拉伯地区
{"title":"Prevalence of BRCA1 and BRCA2 Mutations Among High-risk Bahraini Patients with Breast Cancer.","authors":"Zain Bukamal,&nbsp;Amal AlRayes","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>The purpose is to study the prevalence of BRCA1 and BRCA2 mutations in high-risk Bahraini patients diagnosed with breast cancer, its relation to family history, and to determine the clinicopathologic features of breast cancer associated with these genetic mutations, over a period of 7 years.</p><p><strong>Background: </strong>Breast cancer is the most common type of cancer occurring in women and the second most common type generally. Approximately 12% of women worldwide will develop carcinoma of the breast sometime during their life. Additionally, 72% of women with an inherited BRCA1 mutation and 69% of those with a mutated BRCA2 will develop breast cancer by 80 years of age. The incidence of breast cancer in Bahraini women have increased over the last decade. Still, the data on BRCA1 & BRCA2 mutations in relation to breast cancer patients is limited in the Arab region, not omitting Bahrain as a country with deficient BRCA prevalence data.</p><p><strong>Methods: </strong>This retrospective study was carried out in Salmaniya Medical Complex, Bahrain, to determine the prevalence of BRCA1 and BRCA2 mutations and to observe the breast cancer's histopathologic features that are associated with these mutations.</p><p><strong>Results: </strong>271 patients underwent the BRCA gene testing between 2013 and 2019. Out of 271 patients, 35 were excluded. Out of the 236 breast cancer patients, 219 (93%) did not have the mutation. The BRCA gene was carried by a total of 17 (7%) patients; 13 (5%) BRCA1 and 4 (2%) BRCA2. Thirteen BRCA carrier patients had invasive ductal carcinoma (IDC) (76%), 2 had ductal carcinoma in situ (DCIS) (12%), while 2 patients' histopathology was not available. Molecular subtypes showed 4 triple negative basal sub-type (TNBC), 10 positive ER and PR hormonal status, 1 positive HER-2, while 2 patients' hormonal receptor status was not available. Two BRCA1 carriers had both breast and ovarian cancers. A total of 5 (2%) breast cancer male patients were among the tested population, out of which, 1 (0.4% of the total and 20% of the male patients) was a BRCA2 carrier. Out of the 236 patients, 76 (32%) were younger than 40 years of age at the time of diagnosis. Then again, out of the 17 BRCA carrier patients, 7 (41%) were younger than 40 years.</p><p><strong>Conclusion: </strong>The prevalence of BRCA mutation in high risk Bahraini breast cancer patients is 7%. Among those patients, BRCA1 mutation is the most prevalent (5%) and invasive ductal carcinoma (IDC) is the most common histopathological subtype. However, there was not enough data to conclude the most prevalent molecular subtype of breast cancer in BRCA carriers due to deficiency of overseas pathology reports for patients operated outside Bahrain. When developing treatment plans for younger patients with breast cancer, inherited syndromes and precisely BRCA mutations need to be considered. Bahrain is implementing genetic testing for breast cancer patients","PeriodicalId":53633,"journal":{"name":"The gulf journal of oncology","volume":"1 42","pages":"22-25"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9592165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peptic Ulcer Disease and its Treatments and Risk of Pancreatic Cancer: a Meta-analysis. 消化性溃疡疾病及其治疗与胰腺癌风险:一项荟萃分析
Q3 Medicine Pub Date : 2023-05-01
Nasser Alkhushaym, Goot Albuainain, Tuqa A AbuShaheen, Mohammed Y Alshami, Ali S Almutairi, Ayman Ahmed Sakr, Ayat S Almuhayshi

Background and objective: Pancreatic cancer (PC) is the seventh leading cause of death among cancers mortality. Pancreatic carcinogenesis remains poorly understood. There is still an urge to allocate other related risk factors that may help in better recognition of this pathogenesis. There is increasing evidence suggested that peptic ulcer disease (PUD), and its treatment might affect the development of PC however, studies findings reported conflicting results. Our meta-analysis aimed to study the association between PUD and its treatments (proton pump inhibitors [PPIs] and histamine-2 receptor antagonists [H2RAs]) and risk of PC.

Methods: We searched PubMed/MEDLINE, Embase, and Cochrane library databases from inception through January 2022. We included case-control studies, cohort, and randomized control trials which reported the association between PUD, PPIs, and H2RAs and the risk of PC. Odds ratio (OR) were used to calculate pooled estimates for PC risk. The association were evaluated using random-effects models, in two sided statistical tests.

Results: A total of 22 publications were retained for the meta-analysis. PUD was associated with a significant increase in PC risk (OR 1.26, 95% CI= 1.01-1.57, P= 0.038, I2= 92%). The risk of developing PC were significant in patients receiving PPIs (OR 1.76, 95% CI= 1.26-2.46, P=0.001, I2= 98%) and H2RAs (OR 1.25, 95% CI = 1.042- 1.49, P= 0.016, I2= 80%).

Conclusions: There is a 1.26-fold increase risk of PC in patients with PUD. The elevated PC is also attributable to 1.76-fold greater risk in PPIs group compared to 1.25-fold in H2RAs group.

背景与目的:胰腺癌(PC)是癌症死亡的第七大原因。胰腺癌的发生机制仍然知之甚少。人们仍然迫切需要分配其他相关的危险因素,这可能有助于更好地认识这种发病机制。越来越多的证据表明,消化性溃疡疾病(PUD)及其治疗可能影响PC的发展,然而,研究结果报告了相互矛盾的结果。我们的荟萃分析旨在研究PUD及其治疗(质子泵抑制剂[PPIs]和组胺-2受体拮抗剂[H2RAs])与PC风险之间的关系。方法:检索PubMed/MEDLINE、Embase和Cochrane图书馆数据库,检索时间从成立到2022年1月。我们纳入了病例对照研究、队列研究和随机对照试验,这些研究报告了PUD、PPIs和H2RAs与PC风险之间的关系。比值比(OR)用于计算PC风险的汇总估计。在双侧统计检验中,使用随机效应模型评估这种关联。结果:共有22篇出版物被保留用于meta分析。PUD与PC风险显著增加相关(OR 1.26, 95% CI= 1.01-1.57, P= 0.038, I2= 92%)。接受PPIs的患者发生PC的风险显著(OR 1.76, 95% CI= 1.26-2.46, P=0.001, I2= 98%)和H2RAs (OR 1.25, 95% CI= 1.042- 1.49, P= 0.016, I2= 80%)。结论:PUD患者患PC的风险增加1.26倍。PPIs组PC升高的风险是H2RAs组的1.25倍,而PPIs组是1.76倍。
{"title":"Peptic Ulcer Disease and its Treatments and Risk of Pancreatic Cancer: a Meta-analysis.","authors":"Nasser Alkhushaym,&nbsp;Goot Albuainain,&nbsp;Tuqa A AbuShaheen,&nbsp;Mohammed Y Alshami,&nbsp;Ali S Almutairi,&nbsp;Ayman Ahmed Sakr,&nbsp;Ayat S Almuhayshi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background and objective: </strong>Pancreatic cancer (PC) is the seventh leading cause of death among cancers mortality. Pancreatic carcinogenesis remains poorly understood. There is still an urge to allocate other related risk factors that may help in better recognition of this pathogenesis. There is increasing evidence suggested that peptic ulcer disease (PUD), and its treatment might affect the development of PC however, studies findings reported conflicting results. Our meta-analysis aimed to study the association between PUD and its treatments (proton pump inhibitors [PPIs] and histamine-2 receptor antagonists [H2RAs]) and risk of PC.</p><p><strong>Methods: </strong>We searched PubMed/MEDLINE, Embase, and Cochrane library databases from inception through January 2022. We included case-control studies, cohort, and randomized control trials which reported the association between PUD, PPIs, and H2RAs and the risk of PC. Odds ratio (OR) were used to calculate pooled estimates for PC risk. The association were evaluated using random-effects models, in two sided statistical tests.</p><p><strong>Results: </strong>A total of 22 publications were retained for the meta-analysis. PUD was associated with a significant increase in PC risk (OR 1.26, 95% CI= 1.01-1.57, P= 0.038, I2= 92%). The risk of developing PC were significant in patients receiving PPIs (OR 1.76, 95% CI= 1.26-2.46, P=0.001, I2= 98%) and H2RAs (OR 1.25, 95% CI = 1.042- 1.49, P= 0.016, I2= 80%).</p><p><strong>Conclusions: </strong>There is a 1.26-fold increase risk of PC in patients with PUD. The elevated PC is also attributable to 1.76-fold greater risk in PPIs group compared to 1.25-fold in H2RAs group.</p>","PeriodicalId":53633,"journal":{"name":"The gulf journal of oncology","volume":"1 42","pages":"61-69"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9590895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-Term Outcomes of Limb-Salvage Surgery for Malignant Bone Tumors at a Single Institution in a Developing Country. 发展中国家单一机构恶性骨肿瘤保肢手术的长期疗效。
Q3 Medicine Pub Date : 2023-01-01
Ahmad Shehadeh, Muhamad Al Qawasmi, Adib Edilbi, Iyad Sultan, Taleb Ismael, Sameer Yaser, Abdellatif Al Mousa

Introduction: With the introduction of neoadjuvant chemotherapy, increased expertise in surgical oncology, and advanced skeletal imaging techniques, limb salvage surgery is becoming the standard of care for treating malignant bone tumors. However, few studies have examined the outcomes of limb salvage surgery with relatively large sample sizes in developing countries.

Materials and methods: Therefore, we conducted a retrospective study of 210 patients who received limb salvage surgery at King Hussein Cancer Center in Amman, Jordan, over a follow-up period of 1 to 14.5 years (2006-2019).

Results: Negative resection margins occurred in 203 (96.7%) patients and local control occurred in 178 (84.8%) patients. The mean functionality outcome for all patients was 90%, and 153 (72.9%) patients did not experience any complications. The 10-year survival rate for all patients was 69.7%, and the rate of secondary amputations was 4%.

Conclusion: Therefore, we conclude that the outcomes of limb salvage surgery in a developing country are comparable to those in developed countries when adequate resources and trained orthopedic oncology teams are available.

随着新辅助化疗的引入,外科肿瘤学专业知识的增加,以及先进的骨骼成像技术,肢体保留手术正在成为治疗恶性骨肿瘤的标准治疗方法。然而,在发展中国家,很少有研究以相对大的样本量检查保肢手术的结果。材料和方法:因此,我们对约旦安曼侯赛因国王癌症中心接受肢体保留手术的210例患者进行了回顾性研究,随访时间为1至14.5年(2006-2019)。结果:切除缘阴性203例(96.7%),局部对照178例(84.8%)。所有患者的平均功能结局为90%,153例(72.9%)患者没有出现任何并发症。所有患者10年生存率为69.7%,继发截肢率为4%。结论:因此,我们得出结论,在发展中国家,当有足够的资源和训练有素的骨科肿瘤团队时,肢体保留手术的结果与发达国家相当。
{"title":"Long-Term Outcomes of Limb-Salvage Surgery for Malignant Bone Tumors at a Single Institution in a Developing Country.","authors":"Ahmad Shehadeh,&nbsp;Muhamad Al Qawasmi,&nbsp;Adib Edilbi,&nbsp;Iyad Sultan,&nbsp;Taleb Ismael,&nbsp;Sameer Yaser,&nbsp;Abdellatif Al Mousa","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>With the introduction of neoadjuvant chemotherapy, increased expertise in surgical oncology, and advanced skeletal imaging techniques, limb salvage surgery is becoming the standard of care for treating malignant bone tumors. However, few studies have examined the outcomes of limb salvage surgery with relatively large sample sizes in developing countries.</p><p><strong>Materials and methods: </strong>Therefore, we conducted a retrospective study of 210 patients who received limb salvage surgery at King Hussein Cancer Center in Amman, Jordan, over a follow-up period of 1 to 14.5 years (2006-2019).</p><p><strong>Results: </strong>Negative resection margins occurred in 203 (96.7%) patients and local control occurred in 178 (84.8%) patients. The mean functionality outcome for all patients was 90%, and 153 (72.9%) patients did not experience any complications. The 10-year survival rate for all patients was 69.7%, and the rate of secondary amputations was 4%.</p><p><strong>Conclusion: </strong>Therefore, we conclude that the outcomes of limb salvage surgery in a developing country are comparable to those in developed countries when adequate resources and trained orthopedic oncology teams are available.</p>","PeriodicalId":53633,"journal":{"name":"The gulf journal of oncology","volume":"1 41","pages":"42-53"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10763508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Clinical Staging of OSMF with Habit of Smokeless Tobacco Consumption - Hospital Based Cross Sectional Study. OSMF临床分期与无烟烟草消费习惯的关系——基于医院的横断面研究。
Q3 Medicine Pub Date : 2023-01-01
Ekta A Malvania, Shilpa J Parikh, Vaishanavi Pathak, Pranay B Nayi, Tadrushi A Gandhi, Nidhi N Patel

Background: Oral submucous fibrosis (OSMF), a premalignant condition of oral cavity is associated with usage of smokeless tobacco. The growing prevalence and cultural acceptance of consumption of flavored arecanut and related products along with traditional smokeless tobacco products are confounding the scenario.

Objectives: To find out clinical staging of OSMF and correlate it with consumption of smokeless tobacco usage related factors among subjects with oral sub mucous fibrosis in Ahmedabad city.

Methods: A cross sectional hospital-based study was conducted on 250 randomly selected clinically diagnosed OSMF subjects. The data regarding various demographic details and habit related factors was recorded in a pre-designed study proforma. The data obtained was statistically analyzed.

Results: Among 250 OSMF subjects, 9% were having grade I, 32% were having grade II, 39% were having grade III and 20% were having grade IV OSMF. 81.6% of males and 18.4% of females were having OSMF. The youngest age when habit was initiated was around of 8 years which is alarming in nature. The lowest duration reported to develop OSMF was 6 months. Statistically significant difference was observed between gender, duration, chewing time, swallowing of tobacco juice and clinical staging of OSMF.

Conclusion: It is alarming that around 70% of the total subjects of OSMF were in the younger age group. The community-oriented outreach programs along with strict policy formulation and implementation should be developed to curb the usage of arecanut and smokeless tobacco derivatives.

Key words: arecanut, smokeless tobacco, OSMF.

背景:口腔黏膜下纤维化(OSMF)是一种口腔恶性前病变,与无烟烟草的使用有关。调味槟榔和相关产品以及传统无烟烟草产品的消费日益流行和文化接受度正在使情况变得混乱。目的:了解艾哈迈达巴德市口腔黏膜下纤维化患者OSMF的临床分期及其与无烟烟草使用相关因素的关系。方法:随机选取250例临床诊断为OSMF的患者进行横断面医院研究。有关各种人口统计细节和习惯相关因素的数据记录在预先设计的研究形式中。对所得数据进行统计分析。结果:250例OSMF患者中,I级占9%,II级占32%,III级占39%,IV级占20%。81.6%的男性和18.4%的女性患有OSMF。养成习惯的最小年龄是在8岁左右,这是令人担忧的。据报道,发生OSMF的最短持续时间为6个月。性别、持续时间、咀嚼时间、吞下烟汁与OSMF临床分期差异均有统计学意义。结论:令人担忧的是,约70%的OSMF受试者为低龄组。应制定面向社区的推广方案,同时制定严格的政策和执行,以遏制槟榔和无烟烟草衍生物的使用。关键词:槟榔;无烟烟草;OSMF;
{"title":"Association of Clinical Staging of OSMF with Habit of Smokeless Tobacco Consumption - Hospital Based Cross Sectional Study.","authors":"Ekta A Malvania,&nbsp;Shilpa J Parikh,&nbsp;Vaishanavi Pathak,&nbsp;Pranay B Nayi,&nbsp;Tadrushi A Gandhi,&nbsp;Nidhi N Patel","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Oral submucous fibrosis (OSMF), a premalignant condition of oral cavity is associated with usage of smokeless tobacco. The growing prevalence and cultural acceptance of consumption of flavored arecanut and related products along with traditional smokeless tobacco products are confounding the scenario.</p><p><strong>Objectives: </strong>To find out clinical staging of OSMF and correlate it with consumption of smokeless tobacco usage related factors among subjects with oral sub mucous fibrosis in Ahmedabad city.</p><p><strong>Methods: </strong>A cross sectional hospital-based study was conducted on 250 randomly selected clinically diagnosed OSMF subjects. The data regarding various demographic details and habit related factors was recorded in a pre-designed study proforma. The data obtained was statistically analyzed.</p><p><strong>Results: </strong>Among 250 OSMF subjects, 9% were having grade I, 32% were having grade II, 39% were having grade III and 20% were having grade IV OSMF. 81.6% of males and 18.4% of females were having OSMF. The youngest age when habit was initiated was around of 8 years which is alarming in nature. The lowest duration reported to develop OSMF was 6 months. Statistically significant difference was observed between gender, duration, chewing time, swallowing of tobacco juice and clinical staging of OSMF.</p><p><strong>Conclusion: </strong>It is alarming that around 70% of the total subjects of OSMF were in the younger age group. The community-oriented outreach programs along with strict policy formulation and implementation should be developed to curb the usage of arecanut and smokeless tobacco derivatives.</p><p><strong>Key words: </strong>arecanut, smokeless tobacco, OSMF.</p>","PeriodicalId":53633,"journal":{"name":"The gulf journal of oncology","volume":"1 41","pages":"72-77"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10763956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Desmoid Tumor of the Rectus Abdominis with Urinary Bladder Involvement: A Case Report and Review of Literature. 腹直肌硬纤维瘤累及膀胱1例并文献复习。
Q3 Medicine Pub Date : 2023-01-01
Moath Alfentoukh, Abdulwahab Salih, Mukhtar E Hassan, Osamah Alghamdi, Khadija A Alkhawaja, Mustafa A Ibrahim, Elsanousi Ibrahim Sabir

Desmoid tumors (DTs) account for 3% of all soft tissue tumors. They are benign and have no malignant potential with a favorable prognosis, and predominantly occur in young women. The pathogenesis and clinical behavior of DTs are still uncertain. In addition, most cases of DTs were associated with abdominal trauma (including surgery), while genitourinary involvement seemed to be quite rare. Up to now, there has been only one DT case with urinary bladder involvement reported in the literature. We, Hereby, report a 67-year-old male patient with left lower abdominal pain while micturition. Computed tomography (CT) showed a mass located at the lower aspect of the left rectus muscle with an extension attached to the urinary bladder. Based on the pathological findings of tumor specimen, a diagnosis of benign desmoid tumor (DT) of the abdominal wall was made. Laparotomy with wide local excision was carried out. The patient had a smooth postoperative recovery and was discharged after 10 days. Introduction:Historically, MacFarland first described these tumors in 1832. Etymologically, the word desmoid was first coined by Muller in 1838 and is derived from the Greek word desmos, which means band or tendon-like. Stout first used the term fibromatosis in 1961[1,2,3]. Desmoid tumors (DTs) are a kind of rare neoplasm, which represents 3% of all soft tissue tumors and 0.03% of all neoplasms with an incidence of 5 to 6 per million of the population per annum[4,5,6]. DTs predominantly affect young females with a median age of 30 to 40 years old and is more than twice in female than male patients. However, there is no gender preference in older patients [7,8]. Furthermore, the symptoms of DTs are not typical in general. Symptoms can occasionally occur due to the size and location of the tumor but usually are nonspecific. Because of its rarity and unusual behavior, DT is often associated with diagnostic and therapeutic challenges. Computed tomography (CT) and magnetic resonance imaging (MRI) is beneficial for the diagnosis of this tumor but pathological diagnosis is mandatory. Surgical resection is now considered as the most efficient treatment option for patients with DT, because it offers a good chance of long-term survival. Our case is of unusual presentation and finding of abdominal wall desmoid tumor with an extension to urinary bladder in a male patient who is 67 years old. Keywords: desmoid tumor, fibromatosis, spindle cell tumor, urinary bladder.

硬纤维瘤(DTs)占所有软组织肿瘤的3%。它们是良性的,无恶性潜能,预后良好,主要发生在年轻女性。其发病机制和临床行为尚不清楚。此外,大多数DTs病例与腹部创伤(包括手术)有关,而泌尿生殖系统的累及似乎相当罕见。截至目前,文献中仅报道1例DT伴膀胱受累。我们在此报告一位67岁男性患者,在排尿时出现左下腹疼痛。计算机断层扫描(CT)显示肿块位于左侧直肌下部,并延伸至膀胱。根据肿瘤标本病理表现,诊断为腹壁良性硬纤维瘤(DT)。进行剖腹手术并广泛局部切除。患者术后恢复顺利,10天后出院。从历史上看,MacFarland于1832年首次描述了这些肿瘤。从词源学上讲,desmoid这个词是由Muller于1838年首次创造的,它来源于希腊语desmos,意思是带状或肌腱状。Stout于1961年首次使用纤维瘤病一词[1,2,3]。硬纤维瘤(Desmoid tumors, DTs)是一种罕见的肿瘤,占所有软组织肿瘤的3%,占所有肿瘤的0.03%,每年发病率为5 - 6 /百万人[4,5,6]。DTs主要影响年龄中位数为30至40岁的年轻女性,女性患者是男性患者的两倍多。然而,在老年患者中没有性别偏好[7,8]。此外,抑郁症的症状一般来说并不典型。由于肿瘤的大小和位置,有时会出现症状,但通常是非特异性的。由于其罕见和不寻常的行为,DT通常与诊断和治疗挑战有关。计算机断层扫描(CT)和磁共振成像(MRI)有助于诊断这种肿瘤,但病理诊断是强制性的。手术切除目前被认为是DT患者最有效的治疗选择,因为它提供了很好的长期生存机会。我们的病例是一个不寻常的表现和发现腹壁硬纤维瘤并延伸到膀胱的男性患者,67岁。关键词:硬纤维瘤,纤维瘤病,梭形细胞瘤,膀胱。
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引用次数: 0
Oral Intake of Combined Natural Immunostimulants Suppresses the 7,12-DMBA/ Croton Oil Induced Two-step Skin Carcinogenesis in Swiss Albino Mice. 口服联合天然免疫刺激剂抑制7,12- dmba /巴豆油诱导的瑞士白化小鼠两步皮肤癌
Q3 Medicine Pub Date : 2023-01-01
Mohammed Abdellaoui, Assia Kadi, Yamina Abrazi, Yacine Kadi, Adnane Gary, Hind Kherfi, Zinelaabidine Cheraiet, Mahfoud Messarah

Background: The immune system is critical in fighting cancer, so is it possible that the natural stimulation of this system can slow down or stop the evolution of cancer? Our in vivo study aimed to evaluate the protective effect of the combination of five types of immunostimulants, which are Beta-glucan and Arabinogalactan as polysaccharides and three mushroom extracts (Reishi, Maitake, and Shiitake), on 7,12-Dimethyl Benz[a]anthracene (DMBA)/ Croton oil-induced papilloma in Swiss albino mice.

Methodology: We used blood count analyses to estimate broadly the immunological reaction and biochemical techniques to determine the oxidative stress variations in the enzymatic activity of Superoxide dismutase (SOD), Catalase (CAT), and Glutathion peroxidase (GPx), which could have a preventive function against cancer development.

Results: The cutaneous application of the DMBA/Croton oil caused precancerous hyperplasia in squamous cells (papilloma) on the back of the mice. Tumor development was accompanied by a decrease in SOD and GPx activities. The treatment with the immunostimulants led to the total disappearance of the incidence of skin papillomas and also showed a nearly back to normal SOD activity but not CAT and GPx activities. The increase in the level of immune cells (lymphocytes, monocytes, and white blood cells) reflected a clear enhancement of the immune system activity.

Discussion: The healthy epidermis observed with treated mice simultaneously subjected to the cancerogenosis protocol suggests the inhibition of spinous cell proliferation leading to the total suppression of the hyperplasia. Moreover, the increase in the level of immune cells in this batch reflects an inflammatory reaction. Indeed, previous studies reported that immunostimulants, including Betaglucan involve a release of some inflammatory mediators who would be at the origin of its anticancer activity. Cancerogenesis has clearly disrupted the activities of the antioxidant enzymes, but the relationship between the two process is often complex. Bibliographic data led us to suggest that low catalytic activities of CAT and GPx observed in treated mice simultaneously subjected to the cancerogenesis protocol, would have induce an accumulation of H2O2 which has often been described as an inducer of cancer cells apoptosis.

Conclusion: Immunostimulants used in our study could have an effective protective effect against skin carcinogenesis via the enhancement of the global function of the immune system and modulation of the antioxidant defense.

Keywords: Immunostimulants, Beta-glucan, Arabinogalactan, Reishi, Maitake, Shiitake, DMBA, Croton oil, Oxidative stress, Carcinogenesis.

Abbreviations: C, control group; Dc, drug control group; Pc, positive control group; St, sick treated group;DMBA, 7,12 Dimethyl Benz[a]anthracene; NK, natura

背景:免疫系统在对抗癌症中起着至关重要的作用,那么对免疫系统的自然刺激是否有可能减缓或阻止癌症的发展呢?我们的体内研究旨在评估五种免疫刺激剂(β -葡聚糖和阿拉伯半乳聚糖作为多糖)和三种蘑菇提取物(灵芝、舞茸和香菇)联合使用对7,12-二甲基苯并[a]蒽(DMBA)/巴豆油诱导的瑞士白化小鼠乳头状瘤的保护作用。方法:我们使用血细胞计数分析来广泛估计免疫反应和生化技术来确定氧化应激下超氧化物歧化酶(SOD),过氧化氢酶(CAT)和谷胱甘肽过氧化物酶(GPx)酶活性的变化,这些酶活性可能具有预防癌症发展的功能。结果:DMBA/巴豆油皮肤应用引起小鼠背部鳞状细胞(乳头状瘤)癌前增生。肿瘤的发生伴随着SOD和GPx活性的降低。免疫刺激剂治疗后,皮肤乳头瘤的发生率完全消失,SOD活性几乎恢复正常,但CAT和GPx活性未恢复正常。免疫细胞(淋巴细胞、单核细胞和白细胞)水平的增加反映了免疫系统活性的明显增强。讨论:对同时接受癌变方案治疗的小鼠的健康表皮观察表明,抑制棘细胞增殖导致增生的完全抑制。此外,这批免疫细胞水平的增加反映了炎症反应。事实上,先前的研究报告称,包括倍他卢坎在内的免疫刺激剂涉及一些炎症介质的释放,这些炎症介质可能是其抗癌活性的起源。癌症的发生显然破坏了抗氧化酶的活性,但这两个过程之间的关系往往是复杂的。参考文献数据表明,在同时接受癌变方案的处理小鼠中观察到的CAT和GPx的低催化活性可能会诱导H2O2的积累,而H2O2通常被描述为癌细胞凋亡的诱导剂。结论:本研究使用的免疫刺激剂可能通过增强免疫系统整体功能和调节抗氧化防御,对皮肤癌变具有有效的保护作用。关键词:免疫刺激剂,β -葡聚糖,阿拉伯半乳聚糖,灵芝,舞茸,香菇,DMBA,巴豆油,氧化应激,致癌作用缩写:C, control group;Dc:药物对照组;Pc,阳性对照组;DMBA, 7,12二甲基苯并[a]蒽;NK,自然杀手;猫,过氧化氢酶;超氧化物歧化酶,GPx,谷胱甘肽过氧化物酶;是,免疫增强药;白细胞;LY,淋巴细胞;密苏里州,单核细胞;ROS,活性氧;美国国家统计局(Office national des aliments de bassia)。
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引用次数: 0
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The gulf journal of oncology
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