Pub Date : 2017-12-22DOI: 10.17576/MH.2017.1202.16
Farah Na, I. Saiboon
Intussusception is a common cause of gastrointestinal emergency in the paediatric population and it is usually diagnosed through Barium enema radiography or ultrasound. The skill of using an ultrasound by a minimally trained medical officer in diagnosing this cases in the Emergency Department are very helpful and expedite the management. We present the case of a 7-month-old girl who presented to Emergency Department (ED) with the chief complaint of passing blood in stool. Clinically she was dehydrated, irritable and in compensated shock. There was generalised tenderness per abdomen but it was soft and not distended. There was no palpable mass and bowel sound normal. Immmediate fluid resuscitated commenced. Bedside abdominal ultrasound performed by ED medical officer showed a 1.8 cm x 2.5 cm mass of alternating hypo-echoic and hyper-echoic rings at the right lower quadrant, consistent with the ‘target’ sign of intussusception. Supine plain abdominal X-ray did not reveal any abnormality. The ultrasound finding of intussusception was later confirmed by the radiologist. She underwent immediate hydrostatic reduction and was discharged well.
肠套叠是儿童胃肠道急症的常见原因，通常通过钡灌肠造影或超声诊断。在急诊科，由受过最低限度训练的医务人员使用超声诊断这种病例的技能是非常有帮助的，并加快了管理。我们提出的情况下，一个7个月大的女孩谁提出了急诊科(ED)的主要投诉通过血在粪便。临床表现为脱水、易怒、代偿性休克。腹部有全身性压痛，但柔软而不膨胀。未见肿块，肠音正常。立即开始输液复苏。急诊科医务人员床边腹部超声显示右下象限一个1.8 cm x 2.5 cm的交替低回声和高回声环状肿块，与肠套叠的“靶”征象一致。仰卧位腹部平片未见异常。超声发现的肠套叠后来被放射科医生证实。患者立即接受静压复位，出院情况良好。
{"title":"Diagnosing pediatric intussusception through bedside ultrasound by novice emergency department sonographers: a case report","authors":"Farah Na, I. Saiboon","doi":"10.17576/MH.2017.1202.16","DOIUrl":"https://doi.org/10.17576/MH.2017.1202.16","url":null,"abstract":"Intussusception is a common cause of gastrointestinal emergency in the paediatric population and it is usually diagnosed through Barium enema radiography or ultrasound. The skill of using an ultrasound by a minimally trained medical officer in diagnosing this cases in the Emergency Department are very helpful and expedite the management. We present the case of a 7-month-old girl who presented to Emergency Department (ED) with the chief complaint of passing blood in stool. Clinically she was dehydrated, irritable and in compensated shock. There was generalised tenderness per abdomen but it was soft and not distended. There was no palpable mass and bowel sound normal. Immmediate fluid resuscitated commenced. Bedside abdominal ultrasound performed by ED medical officer showed a 1.8 cm x 2.5 cm mass of alternating hypo-echoic and hyper-echoic rings at the right lower quadrant, consistent with the ‘target’ sign of intussusception. Supine plain abdominal X-ray did not reveal any abnormality. The ultrasound finding of intussusception was later confirmed by the radiologist. She underwent immediate hydrostatic reduction and was discharged well.","PeriodicalId":53946,"journal":{"name":"Medicine and Health","volume":"1 1","pages":"321-328"},"PeriodicalIF":0.2,"publicationDate":"2017-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82969015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-22DOI: 10.17576/MH.2017.1202.09
B. Ng, J. Chuah, P. S. Lim, Shuhaila Ahmad, M. Midin, N. Ismail
Miscarriage is one of the most common complications in pregnancy. There is emerging evidence that psychological impact following miscarriage is not unusual. Understanding the magnitude of psychological morbidity is important in the management of miscarriage. The main objective of this study was to compare the mean Hospital Anxiety and Depression Scale (HADS) score between women with miscarriage and women with successful pregnancy and to determine the socio-demographic factor and clinical characteristic that are associated with anxiety and depression. A descriptive case control study was conducted in a teaching hospital, over a period of 12-months (from October 2014 till September 2015). A total of 65 women were recruited with 32 women as the study group (miscarriage) and another 33 women as the control group (women with successful pregnancy). Mean HADS-anxiety score was higher in the study group compared to control group although it was not statistically significant (6.53 ± 3.427 vs 5.73 ± 2.875, p=0.309). Mean HADS-depression score was higher in the control group (4.34 ± 2.695 vs 4.45 ± 3.073, p=0.878). Women with maternal age more than 35 years and history of previous miscarriage had a higher tendency of anxiety and depression with higher mean HADS score. There was no association between other socio-demographic data and clinical characteristic with risk of anxiety and depression. As conclusion, there was no significant difference in women with miscarriage as compared to those with successful pregnancies, although older women with history of miscarriage had a preponderance to both disorders.
流产是妊娠期最常见的并发症之一。越来越多的证据表明，流产后的心理影响并不罕见。了解心理疾病的严重程度对流产的管理是很重要的。本研究的主要目的是比较流产妇女和成功妊娠妇女的医院焦虑和抑郁量表(HADS)的平均得分，并确定与焦虑和抑郁相关的社会人口统计学因素和临床特征。在一家教学医院进行了为期12个月(2014年10月至2015年9月)的描述性病例对照研究。总共招募了65名妇女，其中32名妇女作为研究组(流产)，另外33名妇女作为对照组(成功怀孕的妇女)。研究组患者的平均hads焦虑评分高于对照组，但差异无统计学意义(6.53±3.427 vs 5.73±2.875,p=0.309)。对照组的平均抑郁评分高于对照组(4.34±2.695 vs 4.45±3.073,p=0.878)。母亲年龄大于35岁且有流产史的女性焦虑和抑郁倾向较高，平均HADS评分也较高。其他社会人口学数据和临床特征与焦虑和抑郁风险之间没有关联。综上所述，流产的妇女与成功怀孕的妇女相比没有显著差异，尽管有流产史的老年妇女患这两种疾病的比例更高。
{"title":"Case control study of anxiety and depression among patients with miscarriage compared to those with successful pregnancy","authors":"B. Ng, J. Chuah, P. S. Lim, Shuhaila Ahmad, M. Midin, N. Ismail","doi":"10.17576/MH.2017.1202.09","DOIUrl":"https://doi.org/10.17576/MH.2017.1202.09","url":null,"abstract":"Miscarriage is one of the most common complications in pregnancy. There is emerging evidence that psychological impact following miscarriage is not unusual. Understanding the magnitude of psychological morbidity is important in the management of miscarriage. The main objective of this study was to compare the mean Hospital Anxiety and Depression Scale (HADS) score between women with miscarriage and women with successful pregnancy and to determine the socio-demographic factor and clinical characteristic that are associated with anxiety and depression. A descriptive case control study was conducted in a teaching hospital, over a period of 12-months (from October 2014 till September 2015). A total of 65 women were recruited with 32 women as the study group (miscarriage) and another 33 women as the control group (women with successful pregnancy). Mean HADS-anxiety score was higher in the study group compared to control group although it was not statistically significant (6.53 ± 3.427 vs 5.73 ± 2.875, p=0.309). Mean HADS-depression score was higher in the control group (4.34 ± 2.695 vs 4.45 ± 3.073, p=0.878). Women with maternal age more than 35 years and history of previous miscarriage had a higher tendency of anxiety and depression with higher mean HADS score. There was no association between other socio-demographic data and clinical characteristic with risk of anxiety and depression. As conclusion, there was no significant difference in women with miscarriage as compared to those with successful pregnancies, although older women with history of miscarriage had a preponderance to both disorders.","PeriodicalId":53946,"journal":{"name":"Medicine and Health","volume":"63 12 1","pages":"244-258"},"PeriodicalIF":0.2,"publicationDate":"2017-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83676420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-22DOI: 10.17576/MH.2017.1202.07
Nuur Ezzatyhusna, Nurul Izzati, Siti Suraiya, Mn
Loop-mediated isothermal amplification (LAMP) is a gene amplification technique whereby the amplification products are commonly visualized as turbidity by naked eye in the presence of magnesium pyrophosphate precipitation. An appropriate intercalating dye is important as it could increase the sensitivity and reduce the false positive and false negative results for the detection. The study aimed to compare the performance of three different intercalating dyes; SYBR Green I, SYBR Safe and calcein-based dyes in HPV-16 LAMP assay by naked-eye visualization, gel electrophoresis and real-time monitoring. The LAMP assay was carried out using a Loopamp DNA amplification kit in 25 μl volumes. The reaction mixture was incubated at 60
环介导等温扩增(LAMP)是一种基因扩增技术，其扩增产物通常在焦磷酸镁沉淀存在下以肉眼可见为浊度。适当的插层染料是重要的，因为它可以提高灵敏度，减少假阳性和假阴性检测结果。本研究旨在比较三种不同插层染料的性能;SYBR Green I、SYBR Safe和calcein基染料在HPV-16 LAMP检测中的裸眼可视化、凝胶电泳和实时监测。LAMP检测采用Loopamp DNA扩增试剂盒，体积为25 μl。反应混合物在60℃下孵育
{"title":"Sensitivity Evaluation of SYBR Green I, SYBR Safe and Calcein Dyes for Detection of Human Papillomavirus 16 by Loop-Mediated Isothermal Amplification","authors":"Nuur Ezzatyhusna, Nurul Izzati, Siti Suraiya, Mn","doi":"10.17576/MH.2017.1202.07","DOIUrl":"https://doi.org/10.17576/MH.2017.1202.07","url":null,"abstract":"Loop-mediated isothermal amplification (LAMP) is a gene amplification technique whereby the amplification products are commonly visualized as turbidity by naked eye in the presence of magnesium pyrophosphate precipitation. An appropriate intercalating dye is important as it could increase the sensitivity and reduce the false positive and false negative results for the detection. The study aimed to compare the performance of three different intercalating dyes; SYBR Green I, SYBR Safe and calcein-based dyes in HPV-16 LAMP assay by naked-eye visualization, gel electrophoresis and real-time monitoring. The LAMP assay was carried out using a Loopamp DNA amplification kit in 25 μl volumes. The reaction mixture was incubated at 60","PeriodicalId":53946,"journal":{"name":"Medicine and Health","volume":"123 1","pages":"220-229"},"PeriodicalIF":0.2,"publicationDate":"2017-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88427159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-12-22DOI: 10.17576/MH.2017.1202.11
Samuel Wong Leong Kheng
Adult influenza and pneumococcal vaccinations are grossly underutilized although there is clear benefit in reducing mortality and morbidity among those at risk. The aim of the study was to assess primary care physician’s knowledge on adult influenza and pneumococcal vaccinations, their beliefs and barriers to vaccination. A cross-sectional study using self-administered questionnaires was conducted at eight primary care centres in Kuching, Sarawak. A total of 108 primary care physicians participated in this study. Median age of participants was 29 years (IQR 4.0). The median knowledge score for influenza vaccine was 9 (IQR 3) and for pneumococcal vaccine was 8 (IQR 4). Female participants scored higher compared to their male counterparts for influenza and pneumococcal vaccines (P = 0.005 & 0.007). The highest percentage of correct responses for influenza vaccination was for side effects (75.3%) while the lowest was for contraindications (9.3%). The highest percentage of correct responses for pneumococcal vaccination was for side effects (69.1%) while the lowest was for advocated target groups (6.2%). Most participants believed that pneumococcal and influenza vaccines were safe (92.8 & 99%) and beneficial for patients (89.7 & 93.8%). Cost of influenza and pneumococcal vaccines (94.8% & 96.9%) and their availability (86.6% & 89.7%) were the main barriers to prescribing them. Primary care physicians in the public sector have moderate knowledge of both adult vaccinations. Areas of knowledge paucity and barriers need to be addressed to ensure a more comprehensive health care delivery to the aging Malaysian population.
{"title":"Knowledge, Belief and Barriers to Adult Influenza and Pneumococcal Vaccination among Primary Care Doctors in Sarawak","authors":"Samuel Wong Leong Kheng","doi":"10.17576/MH.2017.1202.11","DOIUrl":"https://doi.org/10.17576/MH.2017.1202.11","url":null,"abstract":"Adult influenza and pneumococcal vaccinations are grossly underutilized although there is clear benefit in reducing mortality and morbidity among those at risk. The aim of the study was to assess primary care physician’s knowledge on adult influenza and pneumococcal vaccinations, their beliefs and barriers to vaccination. A cross-sectional study using self-administered questionnaires was conducted at eight primary care centres in Kuching, Sarawak. A total of 108 primary care physicians participated in this study. Median age of participants was 29 years (IQR 4.0). The median knowledge score for influenza vaccine was 9 (IQR 3) and for pneumococcal vaccine was 8 (IQR 4). Female participants scored higher compared to their male counterparts for influenza and pneumococcal vaccines (P = 0.005 & 0.007). The highest percentage of correct responses for influenza vaccination was for side effects (75.3%) while the lowest was for contraindications (9.3%). The highest percentage of correct responses for pneumococcal vaccination was for side effects (69.1%) while the lowest was for advocated target groups (6.2%). Most participants believed that pneumococcal and influenza vaccines were safe (92.8 & 99%) and beneficial for patients (89.7 & 93.8%). Cost of influenza and pneumococcal vaccines (94.8% & 96.9%) and their availability (86.6% & 89.7%) were the main barriers to prescribing them. Primary care physicians in the public sector have moderate knowledge of both adult vaccinations. Areas of knowledge paucity and barriers need to be addressed to ensure a more comprehensive health care delivery to the aging Malaysian population.","PeriodicalId":53946,"journal":{"name":"Medicine and Health","volume":"72 1","pages":"275-285"},"PeriodicalIF":0.2,"publicationDate":"2017-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89334963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"10th Malaysia-Indonesia-Brunei Medical Sciences Conference 2017","authors":"Z. M. Isa","doi":"10.17576/MH.2017.s1201","DOIUrl":"https://doi.org/10.17576/MH.2017.s1201","url":null,"abstract":"","PeriodicalId":53946,"journal":{"name":"Medicine and Health","volume":"46 1","pages":"1-149"},"PeriodicalIF":0.2,"publicationDate":"2017-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89940423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.17576/MH.2017.1201.01
R. Rajan, N. Kosai
{"title":"Innovations in obesity and metabolic surgery: boon or bane?","authors":"R. Rajan, N. Kosai","doi":"10.17576/MH.2017.1201.01","DOIUrl":"https://doi.org/10.17576/MH.2017.1201.01","url":null,"abstract":"","PeriodicalId":53946,"journal":{"name":"Medicine and Health","volume":"16 1","pages":"1-3"},"PeriodicalIF":0.2,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87303113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.17576/MH.2017.1201.21
R. Rajan, K. Neeraj, N. Kosai
Sleeve gastrectomy has gained popularity over the years and is commonly performed laparoscopically through multiple small incisions. The arrival of single incision laparoscopic surgery has been a game changer, allowing for sleeve gastrectomy to be performed through a cosmetically more appeasing scar with improved patient satisfaction. In this article, we describe the history, technical challenges, proposed solutions to some of the hurdles faced during single-incision laparoscopic bariatric surgery and highlight our method of performing single incision laparoscopic sleeve gastrectomy purely through a single access device.
{"title":"Single incision laparoscopic bariatric surgery: challenging the conventional","authors":"R. Rajan, K. Neeraj, N. Kosai","doi":"10.17576/MH.2017.1201.21","DOIUrl":"https://doi.org/10.17576/MH.2017.1201.21","url":null,"abstract":"Sleeve gastrectomy has gained popularity over the years and is commonly performed laparoscopically through multiple small incisions. The arrival of single incision laparoscopic surgery has been a game changer, allowing for sleeve gastrectomy to be performed through a cosmetically more appeasing scar with improved patient satisfaction. In this article, we describe the history, technical challenges, proposed solutions to some of the hurdles faced during single-incision laparoscopic bariatric surgery and highlight our method of performing single incision laparoscopic sleeve gastrectomy purely through a single access device.","PeriodicalId":53946,"journal":{"name":"Medicine and Health","volume":"37 1","pages":"143-149"},"PeriodicalIF":0.2,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85942219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.17576/MH.2017.1201.09
M. Mazliadiyana, Nazrun As, I. Mohamed
In Malaysia, sea cucumber is also known as Gamat. Among the Malays, Gamat is frequently used as a traditional or folk medicine to relieve pain, to treat wounds and burns. It is also used as a tonic to provide extra energy. Stichopus chloronotus is one of the species of sea cucumber which is found in Malaysia. An experimental study was carried out to determine the optimum dose of aqueous extract of Stichopus chloronotus on the healing of wounds in rat model. A series of concentrations 0.1%, 0.5% and 1% aqueous extract emulsifying ointment mixed with Stichopus chloronotus was applied once a day for 10 days on the excision wound model. Changes in the wound area were measured using a caliper and photographs were taken on day 1, 3, 6, 8 and 10 after the wound creation. The wound reduction rate and macroscopic observation were evaluated to determine the optimum dose concentration. Results demonstrated that percentage of wound reduction and macroscopic observation of 0.5% aqueous extract Stichopus chloronotus emulsifying ointment mixed group was significantly higher than the other groups from day 6 following wound creation. In conclusion, 0.5% aqueous extract of Stichopus chloronotus emulsifying ointment mixture demonstrated the best dose for wound healing in a rat model.
{"title":"Optimum dose of sea cucumber (Stichopus chloronotus) extract for wound healing","authors":"M. Mazliadiyana, Nazrun As, I. Mohamed","doi":"10.17576/MH.2017.1201.09","DOIUrl":"https://doi.org/10.17576/MH.2017.1201.09","url":null,"abstract":"In Malaysia, sea cucumber is also known as Gamat. Among the Malays, Gamat is frequently used as a traditional or folk medicine to relieve pain, to treat wounds and burns. It is also used as a tonic to provide extra energy. Stichopus chloronotus is one of the species of sea cucumber which is found in Malaysia. An experimental study was carried out to determine the optimum dose of aqueous extract of Stichopus chloronotus on the healing of wounds in rat model. A series of concentrations 0.1%, 0.5% and 1% aqueous extract emulsifying ointment mixed with Stichopus chloronotus was applied once a day for 10 days on the excision wound model. Changes in the wound area were measured using a caliper and photographs were taken on day 1, 3, 6, 8 and 10 after the wound creation. The wound reduction rate and macroscopic observation were evaluated to determine the optimum dose concentration. Results demonstrated that percentage of wound reduction and macroscopic observation of 0.5% aqueous extract Stichopus chloronotus emulsifying ointment mixed group was significantly higher than the other groups from day 6 following wound creation. In conclusion, 0.5% aqueous extract of Stichopus chloronotus emulsifying ointment mixture demonstrated the best dose for wound healing in a rat model.","PeriodicalId":53946,"journal":{"name":"Medicine and Health","volume":"12 1","pages":"83-89"},"PeriodicalIF":0.2,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75423643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.17576/MH.2017.1201.06
Jun Xin Lee, S. Ong, V. Lee, Fairuz Nazri Abd Rahman
Autism Spectrum Disorder (ASD) is a neurodevelopmental childhood disorder associated with cognitive and language impairments. Previous research found that children with developmental disorders increase parenting stress but parents of children with ASD, specifically have recorded higher parenting stress than any other developmental disabilities. Hence, this study investigates the difference in parenting stress levels among parents of children with ASD compared to a typical development (TD) control group. Parenting Stress Index, 3rd Edition Short Form was used to assess the parenting stress levels of 30 parents of children with ASD and 36 parents of TD children. Parents of children with ASD were sampled at Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Tangkak Hospital and National Autism Society of Malaysia (NASOM) in Muar and Segamat. Parents of children with ASD recorded significantly higher levels of parenting stress compared to the TD group (p<0.001). Parents of male children of ASD recorded significantly higher levels of parenting stress compared to the parents of male children of TD group (p<0.001). Parents of female children of ASD also recorded significantly higher levels of parenting stress compared to parents of female children of TD group (p<0.001). Intervention towards ASD children should not only focus on minimizing the core symptoms but should also pay attention to the family’s mental health as well.
{"title":"Parenting stress among Malaysian parents of children with Autism Spectrum Disorder (ASD)","authors":"Jun Xin Lee, S. Ong, V. Lee, Fairuz Nazri Abd Rahman","doi":"10.17576/MH.2017.1201.06","DOIUrl":"https://doi.org/10.17576/MH.2017.1201.06","url":null,"abstract":"Autism Spectrum Disorder (ASD) is a neurodevelopmental childhood disorder associated with cognitive and language impairments. Previous research found that children with developmental disorders increase parenting stress but parents of children with ASD, specifically have recorded higher parenting stress than any other developmental disabilities. Hence, this study investigates the difference in parenting stress levels among parents of children with ASD compared to a typical development (TD) control group. Parenting Stress Index, 3rd Edition Short Form was used to assess the parenting stress levels of 30 parents of children with ASD and 36 parents of TD children. Parents of children with ASD were sampled at Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Tangkak Hospital and National Autism Society of Malaysia (NASOM) in Muar and Segamat. Parents of children with ASD recorded significantly higher levels of parenting stress compared to the TD group (p<0.001). Parents of male children of ASD recorded significantly higher levels of parenting stress compared to the parents of male children of TD group (p<0.001). Parents of female children of ASD also recorded significantly higher levels of parenting stress compared to parents of female children of TD group (p<0.001). Intervention towards ASD children should not only focus on minimizing the core symptoms but should also pay attention to the family’s mental health as well.","PeriodicalId":53946,"journal":{"name":"Medicine and Health","volume":"18 1","pages":"42-55"},"PeriodicalIF":0.2,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84199829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-01-01DOI: 10.17576/MH.2017.1201.13
M. Mardziah, Y. Nurasyikin, T. Rafeah, N. Dian, S. A. Aziz
Plasma cell myeloma is known to cause expansion of a single clone of immunoglobulin (Ig) which results in the secretion of a unique homogeneous monoclonal protein (M component). However, there are cases which reported that it can also cause production of two different clones of these monoclonal M proteins. Although it is relatively very rare as the prevalence is only 2% of all plasma cell myeloma cases, the clinical features are said to be similar to monoclonal gammopathy. It is suggested that these biclonal gammopathy results from either one monoclonal cell clone in monoclonal gammopathy or two different monoclonal cell clones. Whichever the mechanism of the disease be, the response to treatment seems to be similar as compared to the monoclonal cases although some reports shows chemoresistant. Here, we report a rare case of plasma cell myeloma with IgG (lambda) and IgA (lambda) type of biclonal gammopathy, the clinical presentation, the haematological and biochemical markers as well as the response to the treatment.
{"title":"A rare occurrence of plasma cell myeloma with biclonal gammopathy","authors":"M. Mardziah, Y. Nurasyikin, T. Rafeah, N. Dian, S. A. Aziz","doi":"10.17576/MH.2017.1201.13","DOIUrl":"https://doi.org/10.17576/MH.2017.1201.13","url":null,"abstract":"Plasma cell myeloma is known to cause expansion of a single clone of immunoglobulin (Ig) which results in the secretion of a unique homogeneous monoclonal protein (M component). However, there are cases which reported that it can also cause production of two different clones of these monoclonal M proteins. Although it is relatively very rare as the prevalence is only 2% of all plasma cell myeloma cases, the clinical features are said to be similar to monoclonal gammopathy. It is suggested that these biclonal gammopathy results from either one monoclonal cell clone in monoclonal gammopathy or two different monoclonal cell clones. Whichever the mechanism of the disease be, the response to treatment seems to be similar as compared to the monoclonal cases although some reports shows chemoresistant. Here, we report a rare case of plasma cell myeloma with IgG (lambda) and IgA (lambda) type of biclonal gammopathy, the clinical presentation, the haematological and biochemical markers as well as the response to the treatment.","PeriodicalId":53946,"journal":{"name":"Medicine and Health","volume":"20 7 1","pages":"103-108"},"PeriodicalIF":0.2,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83878818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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