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Endodontic Management of Mandibular Premolars with Root Canal Vertucci Type II and III Configuration: Two Case Reports 牙髓治疗下颌前磨牙牙槽型及牙槽型2例报告
IF 0.3 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-06-05 DOI: 10.21103/article13(2)_cr2
Almedin Berisha, Krenare Berisha Elezi, Hekuran Sahatçiu, Shkelqim Azizi, M. Stavileci
The location of all root canals (RCs) and their adequate preparation, disinfection, and obturation play an important role in successful endodontic treatment (ET). Furthermore, in addition to normal RC system morphology, the operator should also recognize their anatomical variations. This study presented two cases of mandibular premolars with RC configuration Vertucci type II and III after a clinical diagnosis of irreversible pulpitis. RC preparation in two cases was performed using the crown-down technique. After following the standard irrigation protocol, the RCs were obturated using the warm vertical condensation technique. Knowledge of RC system variations, with their preparation and 3D obturation, is the appropriate qualification for ET.
所有根管(rc)的位置及其充分的准备、消毒和封闭在成功的根管治疗(ET)中起着重要作用。此外,除了正常的RC系统形态外,操作者还应认识到它们的解剖差异。本文报道2例临床诊断为不可逆性牙髓炎的下颌前磨牙RC型Vertucci II型和III型。在两个病例中,RC制备采用冠状下降技术。在遵循标准灌溉方案后,使用热垂直冷凝技术封闭RCs。了解RC系统的变化,及其制备和三维封闭,是ET的适当资格。
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引用次数: 0
Awareness of Ethical Principles, Professional Behavior, and Ethical Treatment of Patients Among Medical and Dental Students 医学和牙科专业学生的道德原则、职业行为和病人的道德治疗意识
IF 0.3 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-06-05 DOI: 10.21103/article13(2)_oa25
Fehim Haliti, Dion Haliti, Dea Haliti
As future healthcare professionals, medical and dentistry students have an ethical responsibility to establish higher standards of ethics and professionalism in their interactions with patients. Therefore, expanding their knowledge and awareness of ethical concepts, professional behavior, and ethical patient treatment is essential. The aim of this research was to gather information about general medicine and dentistry students' awareness of ethical concepts, professional behavior, and ethical patient treatment. The questionnaire included 16 questions divided into four sections. The study found that most students agreed with basic professional health ethical principles, and that there was no significant difference between the students' directions (general medicine or dentistry) and the year of study (first and fourth). In this research, general medicine and dental students, in general, indicated a good level of awareness of ethical principles, professional behavior, and ethical patient treatment.
作为未来的医疗保健专业人员,医学和牙科专业的学生有道德责任在与患者的互动中建立更高的道德标准和专业精神。因此,扩大他们的知识和意识的伦理观念,职业行为,和道德的病人治疗是必不可少的。摘要本研究旨在了解全科医学及牙科专业学生对伦理观念、职业行为及伦理治疗的认知。问卷包括16个问题,分为四个部分。研究发现,大多数学生认同基本的职业健康伦理原则,学生的方向(普通医学或牙科)和学习年份(一年级和四年级)之间没有显著差异。在本研究中,全科医学和牙科专业的学生普遍表现出良好的道德原则、职业行为和道德患者治疗意识。
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引用次数: 0
Association between the Proinflammatory Cytokine IL-17F and Helicobacter Pylori Infection in a Sample of Iraqi Patients 伊拉克患者血清中促炎细胞因子IL-17F与幽门螺杆菌感染的关系
IF 0.3 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-06-05 DOI: 10.21103/article13(2)_shc
A. Malik, Ali Abas Abood, Sarmad Qassim Mohammad
Background: Infection of the gastric mucosa with Helicobacter pylori (Hp) is characterized by the induction of a number of proinflammatory cytokines, including IL-8, IL-6, and TNF-α, involved in Hp-related gastric inflammation. The functions of members of the IL-17 cytokine family, other than IL-17A, in Hp infection remain understudied. The aim of our study was to assess the association between the proinflammatory cytokine IL-17F and Hp infection in a sample of Iraqi patients. Methods and Results: This study included 50 Iraqi patients (18 males and 32 females; a mean age of 36±1.74 years) infected with Hp. The healthy control group consisted of 16 subjects (3 males and 13 females), with a mean age of 31±2.44 years. For the qualitative detection of antibodies (IgG, IgM, and IgA) against Hp in the serum, we used the OnSite H. pylori Ab Combo Rapid Test (CTK Biotech). ELISA was used to detect levels of human IL-17F in serum using ABTS ELISA Development Kit (Pepro Tech, USA). The serum level of IL-17F in patients with Hp infection was significantly higher than in the control group (238.9±7.64 pg/mL vs. 114.00±3.66 pg/mL, P=0.0001). However, the serum level of IL-17F in Hp patients was not significantly different between men and women (237±12.12 pg/mL and 239±9.94 pg/mL, respectively, P=0.9015). In addition, no significant difference was found between age subgroups: 240±13.18 pg/mL, 231±10.17 pg/mL, and 252±18.35 pg/mL in age subgroups of <30 years, 30-45 years, and >45 years, respectively, (P>0.05). Conclusion: Patients infected with Hp were characterized by higher serum levels of IL-17F than non-Hp subjects. IL-17F plays an important role in the inflammatory response to Hp infection in a sample of Iraqi patients.
背景:幽门螺杆菌(Helicobacter pylori, Hp)感染胃粘膜的特点是诱导多种促炎细胞因子,包括参与Hp相关胃炎症的IL-8、IL-6和TNF-α。除IL-17A外,IL-17细胞因子家族成员在Hp感染中的功能仍未得到充分研究。我们研究的目的是评估伊拉克患者样本中促炎细胞因子IL-17F与Hp感染之间的关系。方法与结果:本研究纳入50例伊拉克患者(男18例,女32例;平均年龄36±1.74岁)感染Hp。健康对照组16例,男3例,女13例,平均年龄(31±2.44)岁。为了定性检测血清中Hp抗体(IgG, IgM和IgA),我们使用了OnSite H. pylori Ab Combo Rapid Test (CTK Biotech)。ELISA检测血清中人IL-17F水平,使用ABTS ELISA Development Kit (Pepro Tech, USA)。Hp感染患者血清IL-17F水平显著高于对照组(238.9±7.64 pg/mL vs. 114.00±3.66 pg/mL, P=0.0001)。而男女Hp患者血清IL-17F水平差异无统计学意义(分别为237±12.12 pg/mL和239±9.94 pg/mL, P=0.9015)。45岁年龄组间差异无统计学意义,分别为240±13.18 pg/mL、231±10.17 pg/mL和252±18.35 pg/mL,差异有统计学意义(P < 0.05)。结论:Hp感染患者血清IL-17F水平高于非Hp患者。IL-17F在伊拉克患者对Hp感染的炎症反应中起重要作用。
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引用次数: 0
Assessment of Red Cell Distribution Width among Sudanese Patients with Subclinical Hypothyroidism 苏丹亚临床甲状腺功能减退症患者红细胞分布宽度的评估
IF 0.3 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-06-05 DOI: 10.21103/article13(2)_oa4
Khalid Abdelsamea Mohamedahmed, Mowahib Omar Mubarak, Albadawi Abdebagi Talha, R. Suliman, A. Abbas, Mosab Omer Khalid Mohammed Zeen, A. Altoum, Asaad Mohammed Babker
Background: Thyroid dysfunction has a strong association with anemia. Red blood cell distribution width (RDW) was traditionally regarded as a part of the routine evaluation of anemia. Several studies have indicated that elevated RDW level is significantly associated with subclinical hypothyroidism and hypothyroidism. The present study aimed to assess the impact of subclinical hypothyroidism (SHT) on RDW in Sudanese patients. Methods and Results: The study was designed as a case-control, laboratory-based study carried out at the National Cancer Institute – University of Gezira (NCI-UG) (Wad Medani, Gezira State, Sudan) from January to October 2020.The samples were collected randomly from 100 subjects: 50 patients (mean age 38.50±10.46 years; 36% males and 64% females) with hypothyroidism (case group) and 50 apparently healthy individuals (mean age 35.52±11.64 years; 46% males and 54% females) (control group). The case group was divided into 2 subgroups: Sub1 included 43(86%) patients with SHT grade 1 (TSH of 6-10μIU/mL), and Sub2 included 7(14%) patients with SHT grade 2 (TSH>10μIU/mL). A 3ml venous blood sample was collected in an EDTA container from each participant. The parameters of the RBCs (RBC count, MCV, RDW-CV, and RDW-SD) were measured using the Sysmex XP-300 Automated Hematology Analyzer. In the case group, the average levels of RDW-SD, RDW-CV, and MCV were higher than in the control group (P=0.000 in all cases). There was a significant difference in RDW-CV between Sub1 and Sub2 (P=0.040). We found no significant differences in RDW-SD and RDW-CV between different age groups. There was a significant difference in RBC count between different age groups (P=0.022), and significant differences in RBC count and MCV between males and females. RDW-SD and RDW-CV had a significant positive correlation within TSH and a significant negative correlation within T3 and T4. Conclusion: RDW-CV may be used as a marker of SHT grade 2.
背景:甲状腺功能障碍与贫血有着密切的关系。红细胞分布宽度(RDW)传统上被认为是贫血常规评估的一部分。几项研究表明,RDW水平升高与亚临床甲状腺功能减退和甲状腺功能减退显著相关。本研究旨在评估亚临床甲状腺功能减退症(SHT)对苏丹患者RDW的影响。方法与结果:本研究为病例对照研究,2020年1月至10月,在国家癌症研究所-格济拉大学(NCI-UG)(苏丹格济拉州Wad Medani)进行的基于实验室的研究。从100名受试者中随机收集样本:50名患有甲状腺功能减退症的患者(平均年龄38.50±10.46岁;36%为男性,64%为女性)(病例组)和50名明显健康的个体(平均年龄35.52±11.64岁;46%为男性,54%为女性)(对照组)。病例组分为2个亚组:亚组1包括43名(86%)SHT 1级(TSH为6-10μIU/mL)患者,亚组2包括7名(14%)SHT 2级(TSH>10μIU/mL)患者。每个参与者在EDTA容器中采集3ml静脉血样。使用Sysmex XP-300自动血液分析仪测量RBC的参数(RBC计数、MCV、RDW-CV和RDW-SD)。病例组的RDW-SD、RDW-CV和MCV的平均水平均高于对照组(所有病例均P=0.000)。Sub1和Sub2的RDW-CV有显著差异(P=0.040)。我们发现不同年龄组的RDW-SD和RDW-CV没有显著差异。红细胞计数在不同年龄组之间存在显著差异(P=0.022),红细胞计数和MCV在男性和女性之间也存在显著差异。RDW-SD和RDW-CV在TSH内呈显著正相关,在T3和T4内呈显著负相关。结论:RDW-CV可作为SHT 2级的标志物。
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引用次数: 0
Organization of the Fibrous Component of Connective Tissue Paraneural Structures in Different Periods of Ontogenesis 胚胎发育不同时期结缔组织副神经结构纤维成分的组织
IF 0.3 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-06-05 DOI: 10.21103/article13(2)_oa19
K. Borodina, Anastasia I Frishko, E. A. Dragovoz, Anastasiya A Mamedova, Elizaveta A Maltseva, E. Mishina, A. Tverskaya, Anatoly V Erofeev, M. Zatolokina
Background: The steady increase in road traffic accidents, seasonal injuries leading to damage to the peripheral nerves of the extremities, as well as the military conflicts that are becoming more frequent now actualize research aimed at improving the diagnosis, treatment, and prevention of post-traumatic changes in the nerve trunks of the extremities. The frequency of peripheral nerve injuries varies from 1.5% to 13% of all injuries in peacetime; and during hostilities, it reaches 20%, and disability is 60%. At the same time, specific destructive changes in the nerves of the extremities after their traumatic injury require extraordinary organizational, therapeutic, and functional approaches to their restoration. The purpose of this study was to evaluate the dynamics of changes in the fibrous component of the paraneurium connective tissue structures in different periods of ontogenesis. Methods and Results: The study consisted of two stages. At the first stage, to study changes in the paraneurium connective tissue of the sciatic nerve (SN) in vivo, ultrasound was performed using an RS85 ultrasound scanner (Samsung Medison, South Korea, 2021) and two linear transducers, LA4-18B and LA2-9A. The thickness of the SN and the surrounding paraneurium were measured, and their structural organization was evaluated. The inclusion criterion was the absence of pathology from the peripheral nervous system. All subjects were divided into four age groups (15 people in each group): Group 1 (0-11 years), Group 2 (12-25 years), Group 3 (26-40 years), and Group 4 (41-60 years). The second stage was performed on cadaveric material of the paraneurium connective tissue of the SN of persons of both sexes, of different ages, whose cause of death was not related to diseases or injuries of the nervous system. To determine the qualitative and quantitative ratio of collagen fibers of different degrees of maturity in the connective tissue structures of the paraneurium tissue of the sciatic nerve, polarization microscopy (MicMed-6, Lomo, Russia) was applied, and the basic principle of double refraction, which in combination with Sirius red staining, made it possible to differentiate types I and III collagen. The amount of each collagen type was determined by analyzing the color gamut after Sirius red staining in polarizing light. Fibers containing type I collagen had a red glow, while those containing type III collagen had a green glow. The ratio of collagen types was calculated using the Fiji program (USA, 2022). US examination revealed the presence of a non-pronounced bilateral asymmetry in the structural organization of the paraneurium and an increase in the thickness of the SN with age, from 0-11 years to the age group of 41-60 years. Polarization microscopy of micro-preparations of the human sciatic nerve with paraneurium structures made it possible to analyze the density of the fibers of the paraneurium connective tissue and identify types I and III of collagen. At the a
背景:道路交通事故的稳步增加,导致四肢周围神经损伤的季节性损伤,以及越来越频繁的军事冲突,现在正在进行旨在改善四肢神经干创伤后变化的诊断、治疗和预防的研究。周围神经损伤的频率在和平时期占所有损伤的1.5%至13%不等;在敌对状态下,这一比例达到20%,残疾率达到60%。同时,创伤后四肢神经的特定破坏性变化需要非凡的组织、治疗和功能方法来修复。本研究的目的是评估在个体发生的不同时期,神经旁结缔组织结构的纤维成分变化的动力学。方法与结果:研究分为两个阶段。在第一阶段,为了研究体内坐骨神经旁结缔组织(SN)的变化,使用RS85超声扫描仪(Samsung Medison,South Korea,2021)和两个线性换能器LA4-18B和LA2-9A进行超声检查。测量SN和周围的副神经层的厚度,并评估其结构组织。纳入标准为周围神经系统无病理。所有受试者被分为四个年龄组(每组15人):第一组(0-11岁)、第二组(12-25岁)、第一组(26-40岁)和第四组(41-60岁)。第二阶段是在不同性别、不同年龄的人的SN副神经结缔组织尸体材料上进行的,其死因与神经系统疾病或损伤无关。为了确定坐骨神经旁神经组织结缔组织结构中不同成熟度胶原纤维的定性和定量比例,应用偏振显微镜(MicMed-6,Lomo,Russia),并结合天狼星红染色的双折射基本原理,使得能够区分I型和III型胶原。通过分析在偏振光中天狼星红染色后的色域来确定每种胶原类型的量。含有I型胶原的纤维发出红光,而含有III型胶原的则发出绿光。胶原蛋白类型的比例是使用斐济计划计算的(美国,2022)。US检查显示,从0-11岁到41-60岁年龄组,副脑结构组织存在不明显的双侧不对称,SN厚度随年龄增加而增加。具有旁神经结构的人坐骨神经微制剂的偏振显微镜使分析旁神经结缔组织的纤维密度和鉴定I型和III型胶原成为可能。在11岁时,I型胶原纤维的数量最多(69.74±0.41%),III型胶原纤维为30.26±0.44%。此外,随着年龄的增长,III型胶原蛋白的数量显著减少。I型胶原与III型胶原的比例随着患者年龄的增长而增加,41-60岁年龄组的比例最高。结论:所揭示的变化动力学与结缔组织的年龄相关特征非常相似,因为正是结缔组织构成了坐骨神经副神经的形态学基底。
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引用次数: 0
Comparative Effectiveness of Aksaritmin and Propafenone in the Prevention of Atrial Fibrillation 阿沙立明与普罗帕酮预防心房颤动的疗效比较
IF 0.3 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-06-05 DOI: 10.21103/article13(2)_oa3
H. Kuchkarov, N. Zakirov, R. Kurbanov
Background: The purpose of this study was to evaluate the efficacy of Aksaritmin (Aks) in comparison with Propafenone (Pr) for the prevention of atrial fibrillation (AF) in patients with none or minimal signs of structural heart disease. Methods and Results: The study included 60 patients aged 18-70 years (mean age of 58.1±7.7 years) with paroxysmal (frequency of more than 2 paroxysms/3 months episodes of AF) or persistent AF with no or minimal signs of structural heart disease. The patients were divided into two groups: Group 1 included 30 patients taking Aks, and Group 2 included 30 patients taking Pr. According to the study protocol, the starting dose of Aks was 75 mg/day, with a possible dose increasing to 112.5 mg/day. The starting dose of Pr was 45 0mg/day, with a possible dose increase to 600 mg/day. In Group 1, preventive efficacy of Aks was observed in 29(96.7%), 26(86.7%), and 24(80%) patients by 1-, 3- and 6-month follow-up, respectively. Of these, 26(86.7%), 22(73.9%), and 16(53.3%) patients showed absolute preventive efficacy of the drug. In Group 2, preventive efficacy of Pr was observed in 28(93.3%), 26(86.7%), and 23(76,7%) patients at 1-, 3- and 6-month follow-up, respectively. Of these, 25(83.3%), 21(70%), and 14(46.7%) patients showed absolute AAE of the Pr. The initial recurrence rate of AF was 4.5±1.4 and 4.2±1.3 in Groups 1 and 2, respectively (P=0.3933 between groups); but after 3 and 6 months of therapy, the recurrence rate decreased to 0.7±1.1 (P<0.0001) and 0.8±1.3 (P<0.0001), and 0.8±1.0 (P<0.0001) and 1.1±1.0 (P<0.0001), respectively, which was statistically significant in both groups. Conclusion: The preventive efficacy of Aks (including in combination with BB) at a dose of 75-112.5mg/day in recurrent forms of AF is comparable to the "reference" drug Pr at a dose of 450-600mg/day.
背景:本研究的目的是评估Aksarimin(Aks)与普罗帕酮(Pr)在无结构性心脏病症状或症状轻微的患者中预防心房颤动(AF)的疗效。方法和结果:该研究纳入了60名年龄在18-70岁(平均年龄58.1±7.7岁)的阵发性(发作频率超过2次/3个月的AF)或持续性AF患者,这些患者没有或只有轻微的结构性心脏病迹象。患者分为两组:第一组包括30名服用Aks的患者,第二组包括30例服用Pr的患者。根据研究方案,Aks的起始剂量为75 mg/天,可能的剂量增加到112.5 mg/天。Pr的起始剂量为45mg/天,可能会增加到600mg/天。在第1组中,通过1个月、3个月和6个月的随访,分别在29名(96.7%)、26名(86.7%)和24名(80%)患者中观察到Aks的预防效果。其中,26名(86.7%)、22名(73.9%)和16名(53.3%)患者显示出该药物的绝对预防效果。在第2组中,在1个月、3个月和6个月的随访中,分别有28名(93.3%)、26名(86.7%)和23名(76.7%)患者观察到Pr的预防效果。其中,25例(83.3%)、21例(70%)和14例(46.7%)患者表现出Pr的绝对AAE。第1组和第2组的AF初始复发率分别为4.5±1.4和4.2±1.3(组间P=0.3933);但治疗3个月和6个月后,复发率分别降至0.7±1.1(P<0.0001)和0.8±1.3(P<0.001),0.8±1.0(P<.0001)和1.1±1.0(P<0.0001,两组均有统计学意义。结论:剂量为75-112.5mg/d的Aks(包括联合BB)对复发性房颤的预防效果与剂量为450-600mg/d的“参考”药物Pr相当。
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引用次数: 0
The Level of Lipid Peroxidation Products and Medium-Molecular-Weight Peptides in Adolescents with Obesity 青少年肥胖中脂质过氧化产物和中分子量肽水平的研究
IF 0.3 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-06-05 DOI: 10.21103/article13(2)_oa17
M. Darenskaya, L. Rychkova, Dolgor B Balzhirova, N. Semenova, O. Nikitina, A. Lesnaya, Natalya Yuzvak, M. Rashidova, L. Kolesnikova
Background: The aim of this research was to study the plasma content of lipid peroxidation products and MMWP in obese adolescents. Materials and Methods: The studies were conducted on 19 adolescent girls and 18 adolescent boys with an established diagnosis of exogenous constitutional obesity of the first degree. Twenty-four adolescent girls and 20 adolescent boys made up control groups. All adolescents were subjected to general clinical examination, including anamnestic data collection, physical examination, anthropometric data analysis, and nutritional status assessment. The content of primary, secondary, and final LPO products was evaluated, as well as MMWP absorbing at wavelengths 238, 254, and 280 nm by the spectrophotometric method. Results. The group of obese adolescent girls, compared to the control, showed lower values of secondary LPO (TBARs) (p=0.022) and elevated levels of MMWP-238 (p<0.0001) and MMWP-280 (p=0.03). The group of obese adolescent boys, compared to the control, showed higher values of secondary LPO products (KD and CT) (p=0.042) and elevated levels of MMWP-238 (p=0.03). Conclusion: The obtained data demonstrate the presence of activation of lipid peroxidation processes at the stage of secondary products in adolescent boys and endogenous intoxication in obese adolescents, regardless of gender. The need to monitor and correct these indicators in adolescent patients with obesity should be an important component of pathogenetic treatment.
背景:本研究的目的是研究肥胖青少年血浆脂质过氧化产物和MMWP的含量。材料与方法:对确诊为一级外源性体质性肥胖的19名少女和18名男孩进行研究。24名青春期女孩和20名青春期男孩组成对照组。所有青少年均接受一般临床检查,包括记忆资料收集、体格检查、人体测量数据分析和营养状况评估。用分光光度法测定了初级、次级和最终LPO产物的含量,以及MMWP在波长238、254和280 nm处的吸收率。结果。与对照组相比,肥胖少女组继发性LPO (TBARs)值较低(p=0.022), MMWP-238 (p<0.0001)和MMWP-280水平升高(p=0.03)。与对照组相比,肥胖男孩组二级LPO产物(KD和CT)值较高(p=0.042), MMWP-238水平升高(p=0.03)。结论:获得的数据表明,在青春期男孩的二次产物阶段和肥胖青少年的内源性中毒阶段,脂质过氧化过程的激活存在,无论性别如何。需要监测和纠正青少年肥胖患者的这些指标应该是病因治疗的重要组成部分。
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引用次数: 0
Hepatic Artery and Portal Vein Hemodynamics in Nonalcoholic Fatty Liver Disease in Adult Saudi Patients: A Doppler Ultrasound Study 沙特成年非酒精性脂肪肝患者肝动脉和门静脉血流动力学:多普勒超声研究
IF 0.3 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-06-05 DOI: 10.21103/article13(2)_oa10
Abdullah Sulaiman Alshehri, M. Gameraddin, Yousef Saeedullah, Marwan Hamid Alaeinbawi, Bilal Rabah Altamimi, Awadia Gareeballah, Suliman Salih, Moa'ath Abdullah Sindi
Background: Nonalcoholic fatty liver disease (NAFLD) is a growing public health problem. With the growing severity of NAFLD, there are considerable alterations in the hemodynamics of the hepatic circulation that might affect the prognosis of the condition, according to numerous reports written to assess the vasculature of the liver in patients affected with fatty liver disease. The aim of the study was to examine hemodynamic alterations in the hepatic artery (HA) and portal vein (PV) in NAFLD patients and determine how they relate to the severity of the condition, and to classify patients into various categories of NAFLD and connect the results to liver size and body mass index (BMI). Methods and Results: One hundred and six diagnosed NAFLD patients who attended the Imaging department at King Fahad Hospital from December 2019 to January 2020 were retrospectively studied. The mean age of the patients was 45.75±15.6 years, with a range of 10-79 years. The patients were examined by a TOSHIBA Xario, SSA-660A ultrasound system utilizing a multifrequency convex transducer (2–5 MHz) for all sonographic exams. B-mode assessed the liver parenchyma, and spectral Doppler estimated the HA and PV. The US appearance of hepatosteatosis, according to the severity of echogenicity, was graded (0-3). Most participants were asymptomatic (76.4%), and diabetes and diabetes with hypertension were diagnosed in 12.3% and 11.3%, respectively. It was observed that grade 1 hepatosteatosis was more prevalent than the other grades: 54 cases versus 41 cases for grade 2 and 11 cases for grade 3. The mean values of liver size and BMI in grade 3 were higher than in grade 1 (P=0.0033 and P=0.0054, respectively). A Spearman test found that the liver size (R=0.19, P=0.05) and BMI (R=0.26, P=0.01) had weak positive, but statistically significant, correlations with the severity of the hepatosteatosis grade. Doppler indices of the HA and PV in NAFLD patients did not differ significantly in hepatosteatosis grades 1-3. Only the PSV and EDV of the main PV showed a significant decrease in the hepatosteatosis grade 2 compared to grade 1 (P=0.0065 and P=0.0234, respectively). Despite the insignificant differences, the Doppler flow parameters of the HA decreased with the severity of hepatic steatosis; for example, the hepatic artery resistive index (HARI) was 0.77±0.16 in grade 1, 0.72±0.16 in grade 2, and 0.75±0.10 in grade 3, respectively. The hepatic artery pulsatility index (HAPI) was 1.62±49 in grade 1, 1.63±.68 in grade 2, and 1.74±0.77 in grade 3. There was also a trend toward a decrease in PSV and end-diastolic velocity (EDV) of HA with the severity of hepatosteatosis. Conclusion: The severity of hepatic steatosis is significantly correlated with liver size and BMI. The blood flow parameters of PV and HA decrease with the severity of hepatic steatosis except for the pulsatility index.
背景:非酒精性脂肪肝(NAFLD)是一个日益严重的公共卫生问题。根据许多评估脂肪肝患者肝脏血管系统的报告,随着NAFLD的日益严重,肝循环的血流动力学发生了相当大的变化,这可能会影响病情的预后。该研究的目的是检查NAFLD患者肝动脉(HA)和门静脉(PV)的血流动力学改变,确定它们与病情严重程度的关系,并将患者分为不同类型的NAFLD,并将结果与肝脏大小和体重指数(BMI)联系起来。方法与结果:对2019年12月至2020年1月在法赫德国王医院影像科就诊的106例NAFLD患者进行回顾性研究。患者平均年龄45.75±15.6岁,年龄范围10 ~ 79岁。所有超声检查均采用东芝Xario, SSA-660A超声系统,采用多频凸换能器(2-5 MHz)。b超检查肝实质,频谱多普勒检查HA和PV。根据超声回声的严重程度,肝骨赘病的超声表现分为(0-3)级。大多数参与者无症状(76.4%),诊断为糖尿病和糖尿病合并高血压的比例分别为12.3%和11.3%。据观察,1级肝骨赘病比其他级别更为普遍:54例,2级41例,3级11例。3级患者肝脏大小和BMI平均值高于1级患者(P=0.0033和P=0.0054)。Spearman检验发现,肝脏大小(R=0.19, P=0.05)和BMI (R=0.26, P=0.01)与肝骨化病分级的严重程度呈弱正相关,但有统计学意义。NAFLD患者HA和PV的多普勒指数在1-3级肝骨化症中无显著差异。与1级相比,只有主PV的PSV和EDV在2级肝纤维化中有显著降低(P=0.0065和P=0.0234)。多普勒血流参数随肝脂肪变性程度的加重而降低,但差异不显著;例如,肝动脉阻力指数(HARI) 1级为0.77±0.16,2级为0.72±0.16,3级为0.75±0.10。肝动脉搏动指数(HAPI) 1级为1.62±49,1级为1.63±。2级为68,3级为1.74±0.77。随着肝纤维化程度的加重,HA的PSV和舒张末期速度(EDV)也有降低的趋势。结论:肝脂肪变性的严重程度与肝脏大小、BMI有显著相关性。除脉搏指数外,PV和HA的血流参数随肝脂肪变性的严重程度而降低。
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引用次数: 0
Presentation of Myopericytoma in the Lower Leg: A Case Report with a Brief Review of the Literature 小腿肌周细胞瘤1例报告并文献复习
IF 0.3 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-06-05 DOI: 10.21103/article13(2)_cr6
Redon Jashari, A. Shabani, Dijon Musliu, Donjet Bislimi, Ardita Kafexholli
Myopericitoma is a rare benign tumor of soft tissue that emerges from perivascular smooth tissue. Myopericitoma primarily derives from soft tissue and skin of the inferior extremities and is rarely found in internal organs. Considering the rare encounter with this neoplasia, it is often misdiagnosed as lipoma or atheroma. Our patient presents with a lump in the lateral region of the Achilles tendon on the right side. On inspection, a small, painful lump of approximately 5 mm×5 mm is noticed without cutaneous changes. In histopathologic examination, branched blood vessels are detected with a characteristic “hemangiopericytoma look-alike” appearance surrounded by prolonged myoid cells.
肌周膜瘤是一种罕见的良性软组织肿瘤,起源于血管周围的平滑组织。肌膜炎主要来源于下肢的软组织和皮肤,在内脏中很少发现。考虑到这种肿瘤的罕见情况,它经常被误诊为脂肪瘤或动脉粥样硬化。我们的患者表现为右侧跟腱外侧区域有一个肿块。检查时,发现一个约5毫米×5毫米的小而疼痛的肿块,没有皮肤变化。在组织病理学检查中,分支血管被延长的类肌细胞包围,具有典型的“血管外皮细胞瘤外观相似”。
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引用次数: 0
The Impact of Aspirin on Stem Cells and Growth Factors: Roles in Dentistry 阿司匹林对干细胞和生长因子的影响:在牙科中的作用
IF 0.3 Q4 MEDICINE, RESEARCH & EXPERIMENTAL Pub Date : 2023-06-05 DOI: 10.21103/article13(2)_ra1
Fazli Abd. Rahman, Nur Fatinazwa Mohd Faizal, L. P. Karen-Ng, Sulinda Daud, A. Zamzuri
The periodontal ligament (PDL) contains a unique population of mesenchymal stem cells (MSCs), also known as PDL stem cells (PDLSCs). The regenerative properties of PDLSCs offer much potential for stem cell-based therapy, particularly for periodontal or bone regeneration. Aspirin (ASA) is a widely used nonsteroidal anti-inflammatory drug (NSAID) that has been reported to modulate a variety of diseases, such as cardiovascular, diabetes, and cancer. This review article focuses on the impacts of ASA on various stem cells. First, we will explain what constitutes PDLSCs and their derivation from periodontal tissues. Then we will discuss the mechanisms of ASA and its effect on periodontal tissues. Next, we focus on aspirin’s effects on the differentiation of various types of stem cells. Finally, we investigate the effects of ASA on growth factors that could enhance the osteoblastic potential of derived stem cells.
牙周膜(PDL)含有独特的间充质干细胞(MSC)群体,也称为PDL干细胞(PDLSCs)。PDLSCs的再生特性为基于干细胞的治疗提供了很大的潜力,特别是在牙周或骨再生方面。阿司匹林(ASA)是一种广泛使用的非甾体抗炎药(NSAID),据报道可调节多种疾病,如心血管、糖尿病和癌症。本文综述ASA对各种干细胞的影响。首先,我们将解释PDLSCs的组成及其从牙周组织的衍生。然后我们将讨论ASA的作用机制及其对牙周组织的影响。接下来,我们重点讨论阿司匹林对各种类型干细胞分化的影响。最后,我们研究了ASA对生长因子的影响,这些生长因子可以增强衍生干细胞的成骨潜能。
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引用次数: 0
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International Journal of Biomedicine
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