The location of all root canals (RCs) and their adequate preparation, disinfection, and obturation play an important role in successful endodontic treatment (ET). Furthermore, in addition to normal RC system morphology, the operator should also recognize their anatomical variations. This study presented two cases of mandibular premolars with RC configuration Vertucci type II and III after a clinical diagnosis of irreversible pulpitis. RC preparation in two cases was performed using the crown-down technique. After following the standard irrigation protocol, the RCs were obturated using the warm vertical condensation technique. Knowledge of RC system variations, with their preparation and 3D obturation, is the appropriate qualification for ET.
{"title":"Endodontic Management of Mandibular Premolars with Root Canal Vertucci Type II and III Configuration: Two Case Reports","authors":"Almedin Berisha, Krenare Berisha Elezi, Hekuran Sahatçiu, Shkelqim Azizi, M. Stavileci","doi":"10.21103/article13(2)_cr2","DOIUrl":"https://doi.org/10.21103/article13(2)_cr2","url":null,"abstract":"The location of all root canals (RCs) and their adequate preparation, disinfection, and obturation play an important role in successful endodontic treatment (ET). Furthermore, in addition to normal RC system morphology, the operator should also recognize their anatomical variations. This study presented two cases of mandibular premolars with RC configuration Vertucci type II and III after a clinical diagnosis of irreversible pulpitis. RC preparation in two cases was performed using the crown-down technique. After following the standard irrigation protocol, the RCs were obturated using the warm vertical condensation technique. Knowledge of RC system variations, with their preparation and 3D obturation, is the appropriate qualification for ET.","PeriodicalId":53991,"journal":{"name":"International Journal of Biomedicine","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44854609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-05DOI: 10.21103/article13(2)_oa25
Fehim Haliti, Dion Haliti, Dea Haliti
As future healthcare professionals, medical and dentistry students have an ethical responsibility to establish higher standards of ethics and professionalism in their interactions with patients. Therefore, expanding their knowledge and awareness of ethical concepts, professional behavior, and ethical patient treatment is essential. The aim of this research was to gather information about general medicine and dentistry students' awareness of ethical concepts, professional behavior, and ethical patient treatment. The questionnaire included 16 questions divided into four sections. The study found that most students agreed with basic professional health ethical principles, and that there was no significant difference between the students' directions (general medicine or dentistry) and the year of study (first and fourth). In this research, general medicine and dental students, in general, indicated a good level of awareness of ethical principles, professional behavior, and ethical patient treatment.
{"title":"Awareness of Ethical Principles, Professional Behavior, and Ethical Treatment of Patients Among Medical and Dental Students","authors":"Fehim Haliti, Dion Haliti, Dea Haliti","doi":"10.21103/article13(2)_oa25","DOIUrl":"https://doi.org/10.21103/article13(2)_oa25","url":null,"abstract":"As future healthcare professionals, medical and dentistry students have an ethical responsibility to establish higher standards of ethics and professionalism in their interactions with patients. Therefore, expanding their knowledge and awareness of ethical concepts, professional behavior, and ethical patient treatment is essential. The aim of this research was to gather information about general medicine and dentistry students' awareness of ethical concepts, professional behavior, and ethical patient treatment. The questionnaire included 16 questions divided into four sections. The study found that most students agreed with basic professional health ethical principles, and that there was no significant difference between the students' directions (general medicine or dentistry) and the year of study (first and fourth). In this research, general medicine and dental students, in general, indicated a good level of awareness of ethical principles, professional behavior, and ethical patient treatment.","PeriodicalId":53991,"journal":{"name":"International Journal of Biomedicine","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45369080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-05DOI: 10.21103/article13(2)_shc
A. Malik, Ali Abas Abood, Sarmad Qassim Mohammad
Background: Infection of the gastric mucosa with Helicobacter pylori (Hp) is characterized by the induction of a number of proinflammatory cytokines, including IL-8, IL-6, and TNF-α, involved in Hp-related gastric inflammation. The functions of members of the IL-17 cytokine family, other than IL-17A, in Hp infection remain understudied. The aim of our study was to assess the association between the proinflammatory cytokine IL-17F and Hp infection in a sample of Iraqi patients. Methods and Results: This study included 50 Iraqi patients (18 males and 32 females; a mean age of 36±1.74 years) infected with Hp. The healthy control group consisted of 16 subjects (3 males and 13 females), with a mean age of 31±2.44 years. For the qualitative detection of antibodies (IgG, IgM, and IgA) against Hp in the serum, we used the OnSite H. pylori Ab Combo Rapid Test (CTK Biotech). ELISA was used to detect levels of human IL-17F in serum using ABTS ELISA Development Kit (Pepro Tech, USA). The serum level of IL-17F in patients with Hp infection was significantly higher than in the control group (238.9±7.64 pg/mL vs. 114.00±3.66 pg/mL, P=0.0001). However, the serum level of IL-17F in Hp patients was not significantly different between men and women (237±12.12 pg/mL and 239±9.94 pg/mL, respectively, P=0.9015). In addition, no significant difference was found between age subgroups: 240±13.18 pg/mL, 231±10.17 pg/mL, and 252±18.35 pg/mL in age subgroups of <30 years, 30-45 years, and >45 years, respectively, (P>0.05). Conclusion: Patients infected with Hp were characterized by higher serum levels of IL-17F than non-Hp subjects. IL-17F plays an important role in the inflammatory response to Hp infection in a sample of Iraqi patients.
背景:幽门螺杆菌(Helicobacter pylori, Hp)感染胃粘膜的特点是诱导多种促炎细胞因子,包括参与Hp相关胃炎症的IL-8、IL-6和TNF-α。除IL-17A外,IL-17细胞因子家族成员在Hp感染中的功能仍未得到充分研究。我们研究的目的是评估伊拉克患者样本中促炎细胞因子IL-17F与Hp感染之间的关系。方法与结果:本研究纳入50例伊拉克患者(男18例,女32例;平均年龄36±1.74岁)感染Hp。健康对照组16例,男3例,女13例,平均年龄(31±2.44)岁。为了定性检测血清中Hp抗体(IgG, IgM和IgA),我们使用了OnSite H. pylori Ab Combo Rapid Test (CTK Biotech)。ELISA检测血清中人IL-17F水平,使用ABTS ELISA Development Kit (Pepro Tech, USA)。Hp感染患者血清IL-17F水平显著高于对照组(238.9±7.64 pg/mL vs. 114.00±3.66 pg/mL, P=0.0001)。而男女Hp患者血清IL-17F水平差异无统计学意义(分别为237±12.12 pg/mL和239±9.94 pg/mL, P=0.9015)。45岁年龄组间差异无统计学意义,分别为240±13.18 pg/mL、231±10.17 pg/mL和252±18.35 pg/mL,差异有统计学意义(P < 0.05)。结论:Hp感染患者血清IL-17F水平高于非Hp患者。IL-17F在伊拉克患者对Hp感染的炎症反应中起重要作用。
{"title":"Association between the Proinflammatory Cytokine IL-17F and Helicobacter Pylori Infection in a Sample of Iraqi Patients","authors":"A. Malik, Ali Abas Abood, Sarmad Qassim Mohammad","doi":"10.21103/article13(2)_shc","DOIUrl":"https://doi.org/10.21103/article13(2)_shc","url":null,"abstract":"Background: Infection of the gastric mucosa with Helicobacter pylori (Hp) is characterized by the induction of a number of proinflammatory cytokines, including IL-8, IL-6, and TNF-α, involved in Hp-related gastric inflammation. The functions of members of the IL-17 cytokine family, other than IL-17A, in Hp infection remain understudied. The aim of our study was to assess the association between the proinflammatory cytokine IL-17F and Hp infection in a sample of Iraqi patients. Methods and Results: This study included 50 Iraqi patients (18 males and 32 females; a mean age of 36±1.74 years) infected with Hp. The healthy control group consisted of 16 subjects (3 males and 13 females), with a mean age of 31±2.44 years. For the qualitative detection of antibodies (IgG, IgM, and IgA) against Hp in the serum, we used the OnSite H. pylori Ab Combo Rapid Test (CTK Biotech). ELISA was used to detect levels of human IL-17F in serum using ABTS ELISA Development Kit (Pepro Tech, USA). The serum level of IL-17F in patients with Hp infection was significantly higher than in the control group (238.9±7.64 pg/mL vs. 114.00±3.66 pg/mL, P=0.0001). However, the serum level of IL-17F in Hp patients was not significantly different between men and women (237±12.12 pg/mL and 239±9.94 pg/mL, respectively, P=0.9015). In addition, no significant difference was found between age subgroups: 240±13.18 pg/mL, 231±10.17 pg/mL, and 252±18.35 pg/mL in age subgroups of <30 years, 30-45 years, and >45 years, respectively, (P>0.05). Conclusion: Patients infected with Hp were characterized by higher serum levels of IL-17F than non-Hp subjects. IL-17F plays an important role in the inflammatory response to Hp infection in a sample of Iraqi patients.","PeriodicalId":53991,"journal":{"name":"International Journal of Biomedicine","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48578304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-05DOI: 10.21103/article13(2)_oa4
Khalid Abdelsamea Mohamedahmed, Mowahib Omar Mubarak, Albadawi Abdebagi Talha, R. Suliman, A. Abbas, Mosab Omer Khalid Mohammed Zeen, A. Altoum, Asaad Mohammed Babker
Background: Thyroid dysfunction has a strong association with anemia. Red blood cell distribution width (RDW) was traditionally regarded as a part of the routine evaluation of anemia. Several studies have indicated that elevated RDW level is significantly associated with subclinical hypothyroidism and hypothyroidism. The present study aimed to assess the impact of subclinical hypothyroidism (SHT) on RDW in Sudanese patients. Methods and Results: The study was designed as a case-control, laboratory-based study carried out at the National Cancer Institute – University of Gezira (NCI-UG) (Wad Medani, Gezira State, Sudan) from January to October 2020.The samples were collected randomly from 100 subjects: 50 patients (mean age 38.50±10.46 years; 36% males and 64% females) with hypothyroidism (case group) and 50 apparently healthy individuals (mean age 35.52±11.64 years; 46% males and 54% females) (control group). The case group was divided into 2 subgroups: Sub1 included 43(86%) patients with SHT grade 1 (TSH of 6-10μIU/mL), and Sub2 included 7(14%) patients with SHT grade 2 (TSH>10μIU/mL). A 3ml venous blood sample was collected in an EDTA container from each participant. The parameters of the RBCs (RBC count, MCV, RDW-CV, and RDW-SD) were measured using the Sysmex XP-300 Automated Hematology Analyzer. In the case group, the average levels of RDW-SD, RDW-CV, and MCV were higher than in the control group (P=0.000 in all cases). There was a significant difference in RDW-CV between Sub1 and Sub2 (P=0.040). We found no significant differences in RDW-SD and RDW-CV between different age groups. There was a significant difference in RBC count between different age groups (P=0.022), and significant differences in RBC count and MCV between males and females. RDW-SD and RDW-CV had a significant positive correlation within TSH and a significant negative correlation within T3 and T4. Conclusion: RDW-CV may be used as a marker of SHT grade 2.
{"title":"Assessment of Red Cell Distribution Width among Sudanese Patients with Subclinical Hypothyroidism","authors":"Khalid Abdelsamea Mohamedahmed, Mowahib Omar Mubarak, Albadawi Abdebagi Talha, R. Suliman, A. Abbas, Mosab Omer Khalid Mohammed Zeen, A. Altoum, Asaad Mohammed Babker","doi":"10.21103/article13(2)_oa4","DOIUrl":"https://doi.org/10.21103/article13(2)_oa4","url":null,"abstract":"Background: Thyroid dysfunction has a strong association with anemia. Red blood cell distribution width (RDW) was traditionally regarded as a part of the routine evaluation of anemia. Several studies have indicated that elevated RDW level is significantly associated with subclinical hypothyroidism and hypothyroidism. The present study aimed to assess the impact of subclinical hypothyroidism (SHT) on RDW in Sudanese patients. Methods and Results: The study was designed as a case-control, laboratory-based study carried out at the National Cancer Institute – University of Gezira (NCI-UG) (Wad Medani, Gezira State, Sudan) from January to October 2020.The samples were collected randomly from 100 subjects: 50 patients (mean age 38.50±10.46 years; 36% males and 64% females) with hypothyroidism (case group) and 50 apparently healthy individuals (mean age 35.52±11.64 years; 46% males and 54% females) (control group). The case group was divided into 2 subgroups: Sub1 included 43(86%) patients with SHT grade 1 (TSH of 6-10μIU/mL), and Sub2 included 7(14%) patients with SHT grade 2 (TSH>10μIU/mL). A 3ml venous blood sample was collected in an EDTA container from each participant. The parameters of the RBCs (RBC count, MCV, RDW-CV, and RDW-SD) were measured using the Sysmex XP-300 Automated Hematology Analyzer. In the case group, the average levels of RDW-SD, RDW-CV, and MCV were higher than in the control group (P=0.000 in all cases). There was a significant difference in RDW-CV between Sub1 and Sub2 (P=0.040). We found no significant differences in RDW-SD and RDW-CV between different age groups. There was a significant difference in RBC count between different age groups (P=0.022), and significant differences in RBC count and MCV between males and females. RDW-SD and RDW-CV had a significant positive correlation within TSH and a significant negative correlation within T3 and T4. Conclusion: RDW-CV may be used as a marker of SHT grade 2.","PeriodicalId":53991,"journal":{"name":"International Journal of Biomedicine","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49639314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-05DOI: 10.21103/article13(2)_oa19
K. Borodina, Anastasia I Frishko, E. A. Dragovoz, Anastasiya A Mamedova, Elizaveta A Maltseva, E. Mishina, A. Tverskaya, Anatoly V Erofeev, M. Zatolokina
Background: The steady increase in road traffic accidents, seasonal injuries leading to damage to the peripheral nerves of the extremities, as well as the military conflicts that are becoming more frequent now actualize research aimed at improving the diagnosis, treatment, and prevention of post-traumatic changes in the nerve trunks of the extremities. The frequency of peripheral nerve injuries varies from 1.5% to 13% of all injuries in peacetime; and during hostilities, it reaches 20%, and disability is 60%. At the same time, specific destructive changes in the nerves of the extremities after their traumatic injury require extraordinary organizational, therapeutic, and functional approaches to their restoration. The purpose of this study was to evaluate the dynamics of changes in the fibrous component of the paraneurium connective tissue structures in different periods of ontogenesis. Methods and Results: The study consisted of two stages. At the first stage, to study changes in the paraneurium connective tissue of the sciatic nerve (SN) in vivo, ultrasound was performed using an RS85 ultrasound scanner (Samsung Medison, South Korea, 2021) and two linear transducers, LA4-18B and LA2-9A. The thickness of the SN and the surrounding paraneurium were measured, and their structural organization was evaluated. The inclusion criterion was the absence of pathology from the peripheral nervous system. All subjects were divided into four age groups (15 people in each group): Group 1 (0-11 years), Group 2 (12-25 years), Group 3 (26-40 years), and Group 4 (41-60 years). The second stage was performed on cadaveric material of the paraneurium connective tissue of the SN of persons of both sexes, of different ages, whose cause of death was not related to diseases or injuries of the nervous system. To determine the qualitative and quantitative ratio of collagen fibers of different degrees of maturity in the connective tissue structures of the paraneurium tissue of the sciatic nerve, polarization microscopy (MicMed-6, Lomo, Russia) was applied, and the basic principle of double refraction, which in combination with Sirius red staining, made it possible to differentiate types I and III collagen. The amount of each collagen type was determined by analyzing the color gamut after Sirius red staining in polarizing light. Fibers containing type I collagen had a red glow, while those containing type III collagen had a green glow. The ratio of collagen types was calculated using the Fiji program (USA, 2022). US examination revealed the presence of a non-pronounced bilateral asymmetry in the structural organization of the paraneurium and an increase in the thickness of the SN with age, from 0-11 years to the age group of 41-60 years. Polarization microscopy of micro-preparations of the human sciatic nerve with paraneurium structures made it possible to analyze the density of the fibers of the paraneurium connective tissue and identify types I and III of collagen. At the a
{"title":"Organization of the Fibrous Component of Connective Tissue Paraneural Structures in Different Periods of Ontogenesis","authors":"K. Borodina, Anastasia I Frishko, E. A. Dragovoz, Anastasiya A Mamedova, Elizaveta A Maltseva, E. Mishina, A. Tverskaya, Anatoly V Erofeev, M. Zatolokina","doi":"10.21103/article13(2)_oa19","DOIUrl":"https://doi.org/10.21103/article13(2)_oa19","url":null,"abstract":"Background: The steady increase in road traffic accidents, seasonal injuries leading to damage to the peripheral nerves of the extremities, as well as the military conflicts that are becoming more frequent now actualize research aimed at improving the diagnosis, treatment, and prevention of post-traumatic changes in the nerve trunks of the extremities. The frequency of peripheral nerve injuries varies from 1.5% to 13% of all injuries in peacetime; and during hostilities, it reaches 20%, and disability is 60%. At the same time, specific destructive changes in the nerves of the extremities after their traumatic injury require extraordinary organizational, therapeutic, and functional approaches to their restoration. The purpose of this study was to evaluate the dynamics of changes in the fibrous component of the paraneurium connective tissue structures in different periods of ontogenesis. Methods and Results: The study consisted of two stages. At the first stage, to study changes in the paraneurium connective tissue of the sciatic nerve (SN) in vivo, ultrasound was performed using an RS85 ultrasound scanner (Samsung Medison, South Korea, 2021) and two linear transducers, LA4-18B and LA2-9A. The thickness of the SN and the surrounding paraneurium were measured, and their structural organization was evaluated. The inclusion criterion was the absence of pathology from the peripheral nervous system. All subjects were divided into four age groups (15 people in each group): Group 1 (0-11 years), Group 2 (12-25 years), Group 3 (26-40 years), and Group 4 (41-60 years). The second stage was performed on cadaveric material of the paraneurium connective tissue of the SN of persons of both sexes, of different ages, whose cause of death was not related to diseases or injuries of the nervous system. To determine the qualitative and quantitative ratio of collagen fibers of different degrees of maturity in the connective tissue structures of the paraneurium tissue of the sciatic nerve, polarization microscopy (MicMed-6, Lomo, Russia) was applied, and the basic principle of double refraction, which in combination with Sirius red staining, made it possible to differentiate types I and III collagen. The amount of each collagen type was determined by analyzing the color gamut after Sirius red staining in polarizing light. Fibers containing type I collagen had a red glow, while those containing type III collagen had a green glow. The ratio of collagen types was calculated using the Fiji program (USA, 2022). US examination revealed the presence of a non-pronounced bilateral asymmetry in the structural organization of the paraneurium and an increase in the thickness of the SN with age, from 0-11 years to the age group of 41-60 years. Polarization microscopy of micro-preparations of the human sciatic nerve with paraneurium structures made it possible to analyze the density of the fibers of the paraneurium connective tissue and identify types I and III of collagen. At the a","PeriodicalId":53991,"journal":{"name":"International Journal of Biomedicine","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43059681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-05DOI: 10.21103/article13(2)_oa3
H. Kuchkarov, N. Zakirov, R. Kurbanov
Background: The purpose of this study was to evaluate the efficacy of Aksaritmin (Aks) in comparison with Propafenone (Pr) for the prevention of atrial fibrillation (AF) in patients with none or minimal signs of structural heart disease. Methods and Results: The study included 60 patients aged 18-70 years (mean age of 58.1±7.7 years) with paroxysmal (frequency of more than 2 paroxysms/3 months episodes of AF) or persistent AF with no or minimal signs of structural heart disease. The patients were divided into two groups: Group 1 included 30 patients taking Aks, and Group 2 included 30 patients taking Pr. According to the study protocol, the starting dose of Aks was 75 mg/day, with a possible dose increasing to 112.5 mg/day. The starting dose of Pr was 45 0mg/day, with a possible dose increase to 600 mg/day. In Group 1, preventive efficacy of Aks was observed in 29(96.7%), 26(86.7%), and 24(80%) patients by 1-, 3- and 6-month follow-up, respectively. Of these, 26(86.7%), 22(73.9%), and 16(53.3%) patients showed absolute preventive efficacy of the drug. In Group 2, preventive efficacy of Pr was observed in 28(93.3%), 26(86.7%), and 23(76,7%) patients at 1-, 3- and 6-month follow-up, respectively. Of these, 25(83.3%), 21(70%), and 14(46.7%) patients showed absolute AAE of the Pr. The initial recurrence rate of AF was 4.5±1.4 and 4.2±1.3 in Groups 1 and 2, respectively (P=0.3933 between groups); but after 3 and 6 months of therapy, the recurrence rate decreased to 0.7±1.1 (P<0.0001) and 0.8±1.3 (P<0.0001), and 0.8±1.0 (P<0.0001) and 1.1±1.0 (P<0.0001), respectively, which was statistically significant in both groups. Conclusion: The preventive efficacy of Aks (including in combination with BB) at a dose of 75-112.5mg/day in recurrent forms of AF is comparable to the "reference" drug Pr at a dose of 450-600mg/day.
{"title":"Comparative Effectiveness of Aksaritmin and Propafenone in the Prevention of Atrial Fibrillation","authors":"H. Kuchkarov, N. Zakirov, R. Kurbanov","doi":"10.21103/article13(2)_oa3","DOIUrl":"https://doi.org/10.21103/article13(2)_oa3","url":null,"abstract":"Background: The purpose of this study was to evaluate the efficacy of Aksaritmin (Aks) in comparison with Propafenone (Pr) for the prevention of atrial fibrillation (AF) in patients with none or minimal signs of structural heart disease. Methods and Results: The study included 60 patients aged 18-70 years (mean age of 58.1±7.7 years) with paroxysmal (frequency of more than 2 paroxysms/3 months episodes of AF) or persistent AF with no or minimal signs of structural heart disease. The patients were divided into two groups: Group 1 included 30 patients taking Aks, and Group 2 included 30 patients taking Pr. According to the study protocol, the starting dose of Aks was 75 mg/day, with a possible dose increasing to 112.5 mg/day. The starting dose of Pr was 45 0mg/day, with a possible dose increase to 600 mg/day. In Group 1, preventive efficacy of Aks was observed in 29(96.7%), 26(86.7%), and 24(80%) patients by 1-, 3- and 6-month follow-up, respectively. Of these, 26(86.7%), 22(73.9%), and 16(53.3%) patients showed absolute preventive efficacy of the drug. In Group 2, preventive efficacy of Pr was observed in 28(93.3%), 26(86.7%), and 23(76,7%) patients at 1-, 3- and 6-month follow-up, respectively. Of these, 25(83.3%), 21(70%), and 14(46.7%) patients showed absolute AAE of the Pr. The initial recurrence rate of AF was 4.5±1.4 and 4.2±1.3 in Groups 1 and 2, respectively (P=0.3933 between groups); but after 3 and 6 months of therapy, the recurrence rate decreased to 0.7±1.1 (P<0.0001) and 0.8±1.3 (P<0.0001), and 0.8±1.0 (P<0.0001) and 1.1±1.0 (P<0.0001), respectively, which was statistically significant in both groups. Conclusion: The preventive efficacy of Aks (including in combination with BB) at a dose of 75-112.5mg/day in recurrent forms of AF is comparable to the \"reference\" drug Pr at a dose of 450-600mg/day.","PeriodicalId":53991,"journal":{"name":"International Journal of Biomedicine","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49459371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-05DOI: 10.21103/article13(2)_oa17
M. Darenskaya, L. Rychkova, Dolgor B Balzhirova, N. Semenova, O. Nikitina, A. Lesnaya, Natalya Yuzvak, M. Rashidova, L. Kolesnikova
Background: The aim of this research was to study the plasma content of lipid peroxidation products and MMWP in obese adolescents. Materials and Methods: The studies were conducted on 19 adolescent girls and 18 adolescent boys with an established diagnosis of exogenous constitutional obesity of the first degree. Twenty-four adolescent girls and 20 adolescent boys made up control groups. All adolescents were subjected to general clinical examination, including anamnestic data collection, physical examination, anthropometric data analysis, and nutritional status assessment. The content of primary, secondary, and final LPO products was evaluated, as well as MMWP absorbing at wavelengths 238, 254, and 280 nm by the spectrophotometric method. Results. The group of obese adolescent girls, compared to the control, showed lower values of secondary LPO (TBARs) (p=0.022) and elevated levels of MMWP-238 (p<0.0001) and MMWP-280 (p=0.03). The group of obese adolescent boys, compared to the control, showed higher values of secondary LPO products (KD and CT) (p=0.042) and elevated levels of MMWP-238 (p=0.03). Conclusion: The obtained data demonstrate the presence of activation of lipid peroxidation processes at the stage of secondary products in adolescent boys and endogenous intoxication in obese adolescents, regardless of gender. The need to monitor and correct these indicators in adolescent patients with obesity should be an important component of pathogenetic treatment.
{"title":"The Level of Lipid Peroxidation Products and Medium-Molecular-Weight Peptides in Adolescents with Obesity","authors":"M. Darenskaya, L. Rychkova, Dolgor B Balzhirova, N. Semenova, O. Nikitina, A. Lesnaya, Natalya Yuzvak, M. Rashidova, L. Kolesnikova","doi":"10.21103/article13(2)_oa17","DOIUrl":"https://doi.org/10.21103/article13(2)_oa17","url":null,"abstract":"Background: The aim of this research was to study the plasma content of lipid peroxidation products and MMWP in obese adolescents. Materials and Methods: The studies were conducted on 19 adolescent girls and 18 adolescent boys with an established diagnosis of exogenous constitutional obesity of the first degree. Twenty-four adolescent girls and 20 adolescent boys made up control groups. All adolescents were subjected to general clinical examination, including anamnestic data collection, physical examination, anthropometric data analysis, and nutritional status assessment. The content of primary, secondary, and final LPO products was evaluated, as well as MMWP absorbing at wavelengths 238, 254, and 280 nm by the spectrophotometric method. Results. The group of obese adolescent girls, compared to the control, showed lower values of secondary LPO (TBARs) (p=0.022) and elevated levels of MMWP-238 (p<0.0001) and MMWP-280 (p=0.03). The group of obese adolescent boys, compared to the control, showed higher values of secondary LPO products (KD and CT) (p=0.042) and elevated levels of MMWP-238 (p=0.03). Conclusion: The obtained data demonstrate the presence of activation of lipid peroxidation processes at the stage of secondary products in adolescent boys and endogenous intoxication in obese adolescents, regardless of gender. The need to monitor and correct these indicators in adolescent patients with obesity should be an important component of pathogenetic treatment.","PeriodicalId":53991,"journal":{"name":"International Journal of Biomedicine","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46862824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-05DOI: 10.21103/article13(2)_oa10
Abdullah Sulaiman Alshehri, M. Gameraddin, Yousef Saeedullah, Marwan Hamid Alaeinbawi, Bilal Rabah Altamimi, Awadia Gareeballah, Suliman Salih, Moa'ath Abdullah Sindi
Background: Nonalcoholic fatty liver disease (NAFLD) is a growing public health problem. With the growing severity of NAFLD, there are considerable alterations in the hemodynamics of the hepatic circulation that might affect the prognosis of the condition, according to numerous reports written to assess the vasculature of the liver in patients affected with fatty liver disease. The aim of the study was to examine hemodynamic alterations in the hepatic artery (HA) and portal vein (PV) in NAFLD patients and determine how they relate to the severity of the condition, and to classify patients into various categories of NAFLD and connect the results to liver size and body mass index (BMI). Methods and Results: One hundred and six diagnosed NAFLD patients who attended the Imaging department at King Fahad Hospital from December 2019 to January 2020 were retrospectively studied. The mean age of the patients was 45.75±15.6 years, with a range of 10-79 years. The patients were examined by a TOSHIBA Xario, SSA-660A ultrasound system utilizing a multifrequency convex transducer (2–5 MHz) for all sonographic exams. B-mode assessed the liver parenchyma, and spectral Doppler estimated the HA and PV. The US appearance of hepatosteatosis, according to the severity of echogenicity, was graded (0-3). Most participants were asymptomatic (76.4%), and diabetes and diabetes with hypertension were diagnosed in 12.3% and 11.3%, respectively. It was observed that grade 1 hepatosteatosis was more prevalent than the other grades: 54 cases versus 41 cases for grade 2 and 11 cases for grade 3. The mean values of liver size and BMI in grade 3 were higher than in grade 1 (P=0.0033 and P=0.0054, respectively). A Spearman test found that the liver size (R=0.19, P=0.05) and BMI (R=0.26, P=0.01) had weak positive, but statistically significant, correlations with the severity of the hepatosteatosis grade. Doppler indices of the HA and PV in NAFLD patients did not differ significantly in hepatosteatosis grades 1-3. Only the PSV and EDV of the main PV showed a significant decrease in the hepatosteatosis grade 2 compared to grade 1 (P=0.0065 and P=0.0234, respectively). Despite the insignificant differences, the Doppler flow parameters of the HA decreased with the severity of hepatic steatosis; for example, the hepatic artery resistive index (HARI) was 0.77±0.16 in grade 1, 0.72±0.16 in grade 2, and 0.75±0.10 in grade 3, respectively. The hepatic artery pulsatility index (HAPI) was 1.62±49 in grade 1, 1.63±.68 in grade 2, and 1.74±0.77 in grade 3. There was also a trend toward a decrease in PSV and end-diastolic velocity (EDV) of HA with the severity of hepatosteatosis. Conclusion: The severity of hepatic steatosis is significantly correlated with liver size and BMI. The blood flow parameters of PV and HA decrease with the severity of hepatic steatosis except for the pulsatility index.
{"title":"Hepatic Artery and Portal Vein Hemodynamics in Nonalcoholic Fatty Liver Disease in Adult Saudi Patients: A Doppler Ultrasound Study","authors":"Abdullah Sulaiman Alshehri, M. Gameraddin, Yousef Saeedullah, Marwan Hamid Alaeinbawi, Bilal Rabah Altamimi, Awadia Gareeballah, Suliman Salih, Moa'ath Abdullah Sindi","doi":"10.21103/article13(2)_oa10","DOIUrl":"https://doi.org/10.21103/article13(2)_oa10","url":null,"abstract":"Background: Nonalcoholic fatty liver disease (NAFLD) is a growing public health problem. With the growing severity of NAFLD, there are considerable alterations in the hemodynamics of the hepatic circulation that might affect the prognosis of the condition, according to numerous reports written to assess the vasculature of the liver in patients affected with fatty liver disease. The aim of the study was to examine hemodynamic alterations in the hepatic artery (HA) and portal vein (PV) in NAFLD patients and determine how they relate to the severity of the condition, and to classify patients into various categories of NAFLD and connect the results to liver size and body mass index (BMI). Methods and Results: One hundred and six diagnosed NAFLD patients who attended the Imaging department at King Fahad Hospital from December 2019 to January 2020 were retrospectively studied. The mean age of the patients was 45.75±15.6 years, with a range of 10-79 years. The patients were examined by a TOSHIBA Xario, SSA-660A ultrasound system utilizing a multifrequency convex transducer (2–5 MHz) for all sonographic exams. B-mode assessed the liver parenchyma, and spectral Doppler estimated the HA and PV. The US appearance of hepatosteatosis, according to the severity of echogenicity, was graded (0-3). Most participants were asymptomatic (76.4%), and diabetes and diabetes with hypertension were diagnosed in 12.3% and 11.3%, respectively. It was observed that grade 1 hepatosteatosis was more prevalent than the other grades: 54 cases versus 41 cases for grade 2 and 11 cases for grade 3. The mean values of liver size and BMI in grade 3 were higher than in grade 1 (P=0.0033 and P=0.0054, respectively). A Spearman test found that the liver size (R=0.19, P=0.05) and BMI (R=0.26, P=0.01) had weak positive, but statistically significant, correlations with the severity of the hepatosteatosis grade. Doppler indices of the HA and PV in NAFLD patients did not differ significantly in hepatosteatosis grades 1-3. Only the PSV and EDV of the main PV showed a significant decrease in the hepatosteatosis grade 2 compared to grade 1 (P=0.0065 and P=0.0234, respectively). Despite the insignificant differences, the Doppler flow parameters of the HA decreased with the severity of hepatic steatosis; for example, the hepatic artery resistive index (HARI) was 0.77±0.16 in grade 1, 0.72±0.16 in grade 2, and 0.75±0.10 in grade 3, respectively. The hepatic artery pulsatility index (HAPI) was 1.62±49 in grade 1, 1.63±.68 in grade 2, and 1.74±0.77 in grade 3. There was also a trend toward a decrease in PSV and end-diastolic velocity (EDV) of HA with the severity of hepatosteatosis. Conclusion: The severity of hepatic steatosis is significantly correlated with liver size and BMI. The blood flow parameters of PV and HA decrease with the severity of hepatic steatosis except for the pulsatility index.","PeriodicalId":53991,"journal":{"name":"International Journal of Biomedicine","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46962551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-05DOI: 10.21103/article13(2)_cr6
Redon Jashari, A. Shabani, Dijon Musliu, Donjet Bislimi, Ardita Kafexholli
Myopericitoma is a rare benign tumor of soft tissue that emerges from perivascular smooth tissue. Myopericitoma primarily derives from soft tissue and skin of the inferior extremities and is rarely found in internal organs. Considering the rare encounter with this neoplasia, it is often misdiagnosed as lipoma or atheroma. Our patient presents with a lump in the lateral region of the Achilles tendon on the right side. On inspection, a small, painful lump of approximately 5 mm×5 mm is noticed without cutaneous changes. In histopathologic examination, branched blood vessels are detected with a characteristic “hemangiopericytoma look-alike” appearance surrounded by prolonged myoid cells.
{"title":"Presentation of Myopericytoma in the Lower Leg: A Case Report with a Brief Review of the Literature","authors":"Redon Jashari, A. Shabani, Dijon Musliu, Donjet Bislimi, Ardita Kafexholli","doi":"10.21103/article13(2)_cr6","DOIUrl":"https://doi.org/10.21103/article13(2)_cr6","url":null,"abstract":"Myopericitoma is a rare benign tumor of soft tissue that emerges from perivascular smooth tissue. Myopericitoma primarily derives from soft tissue and skin of the inferior extremities and is rarely found in internal organs. Considering the rare encounter with this neoplasia, it is often misdiagnosed as lipoma or atheroma. Our patient presents with a lump in the lateral region of the Achilles tendon on the right side. On inspection, a small, painful lump of approximately 5 mm×5 mm is noticed without cutaneous changes. In histopathologic examination, branched blood vessels are detected with a characteristic “hemangiopericytoma look-alike” appearance surrounded by prolonged myoid cells.","PeriodicalId":53991,"journal":{"name":"International Journal of Biomedicine","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44809909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-05DOI: 10.21103/article13(2)_ra1
Fazli Abd. Rahman, Nur Fatinazwa Mohd Faizal, L. P. Karen-Ng, Sulinda Daud, A. Zamzuri
The periodontal ligament (PDL) contains a unique population of mesenchymal stem cells (MSCs), also known as PDL stem cells (PDLSCs). The regenerative properties of PDLSCs offer much potential for stem cell-based therapy, particularly for periodontal or bone regeneration. Aspirin (ASA) is a widely used nonsteroidal anti-inflammatory drug (NSAID) that has been reported to modulate a variety of diseases, such as cardiovascular, diabetes, and cancer. This review article focuses on the impacts of ASA on various stem cells. First, we will explain what constitutes PDLSCs and their derivation from periodontal tissues. Then we will discuss the mechanisms of ASA and its effect on periodontal tissues. Next, we focus on aspirin’s effects on the differentiation of various types of stem cells. Finally, we investigate the effects of ASA on growth factors that could enhance the osteoblastic potential of derived stem cells.
{"title":"The Impact of Aspirin on Stem Cells and Growth Factors: Roles in Dentistry","authors":"Fazli Abd. Rahman, Nur Fatinazwa Mohd Faizal, L. P. Karen-Ng, Sulinda Daud, A. Zamzuri","doi":"10.21103/article13(2)_ra1","DOIUrl":"https://doi.org/10.21103/article13(2)_ra1","url":null,"abstract":"The periodontal ligament (PDL) contains a unique population of mesenchymal stem cells (MSCs), also known as PDL stem cells (PDLSCs). The regenerative properties of PDLSCs offer much potential for stem cell-based therapy, particularly for periodontal or bone regeneration. Aspirin (ASA) is a widely used nonsteroidal anti-inflammatory drug (NSAID) that has been reported to modulate a variety of diseases, such as cardiovascular, diabetes, and cancer. This review article focuses on the impacts of ASA on various stem cells. First, we will explain what constitutes PDLSCs and their derivation from periodontal tissues. Then we will discuss the mechanisms of ASA and its effect on periodontal tissues. Next, we focus on aspirin’s effects on the differentiation of various types of stem cells. Finally, we investigate the effects of ASA on growth factors that could enhance the osteoblastic potential of derived stem cells.","PeriodicalId":53991,"journal":{"name":"International Journal of Biomedicine","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43930328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}