Pub Date : 2025-12-11DOI: 10.1021/acs.nanolett.5c05218
Jie Ma,Ziyong Cheng,Meng Yuan,Zhuang Yang,Zhizi Ma,Xiaorui Chen,Jiashi Zhang,Ziyao Li,Ping'an Ma,Jun Lin
The recent rise of piezoelectronic technology has revitalized ultrasound-mediated tumor therapy through sonopiezoelectric therapy (SPT). However, piezoelectric semiconductor nanomaterials used as sonocatalysts still face challenges. On the one hand, its sonocatalytic efficiency requires improvement; on the other hand, its catalytic selectivity remains poor. Therefore, enhancing the yield of highly cytotoxic catalytic products is of significant importance. Chiral-Induced Spin Selectivity (CISS) provides a robust foundation for controlling catalytic reaction processes, thereby boosting the yield of highly cytotoxic products. This study pioneers the integration of the CISS effect into sonodynamic tumor therapy, significantly boosting the therapeutic efficacy. Employing R-MBA_MoS2/S-MBA_MoS2/rac-MBA_MoS2 as sonocatalysts, we investigated the enhancement of SPT by chiral molecules. The results demonstrate a significant increase in the yield of ·OH and O2, exhibiting outstanding antitumor efficacy. This phenomenon is attributed to the CISS effect. This study aims to achieve chirality-enhanced sonocatalytic antitumor therapy, opening new avenues for simple and efficient cancer treatment.
{"title":"Achieving Efficient Sonopiezoelectric Therapy for Tumor through Electron Spin Modulation via the Chiral-Induced Spin Selectivity Effect.","authors":"Jie Ma,Ziyong Cheng,Meng Yuan,Zhuang Yang,Zhizi Ma,Xiaorui Chen,Jiashi Zhang,Ziyao Li,Ping'an Ma,Jun Lin","doi":"10.1021/acs.nanolett.5c05218","DOIUrl":"https://doi.org/10.1021/acs.nanolett.5c05218","url":null,"abstract":"The recent rise of piezoelectronic technology has revitalized ultrasound-mediated tumor therapy through sonopiezoelectric therapy (SPT). However, piezoelectric semiconductor nanomaterials used as sonocatalysts still face challenges. On the one hand, its sonocatalytic efficiency requires improvement; on the other hand, its catalytic selectivity remains poor. Therefore, enhancing the yield of highly cytotoxic catalytic products is of significant importance. Chiral-Induced Spin Selectivity (CISS) provides a robust foundation for controlling catalytic reaction processes, thereby boosting the yield of highly cytotoxic products. This study pioneers the integration of the CISS effect into sonodynamic tumor therapy, significantly boosting the therapeutic efficacy. Employing R-MBA_MoS2/S-MBA_MoS2/rac-MBA_MoS2 as sonocatalysts, we investigated the enhancement of SPT by chiral molecules. The results demonstrate a significant increase in the yield of ·OH and O2, exhibiting outstanding antitumor efficacy. This phenomenon is attributed to the CISS effect. This study aims to achieve chirality-enhanced sonocatalytic antitumor therapy, opening new avenues for simple and efficient cancer treatment.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"9 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145718331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Developing sensitizers for highly efficient molecular spin-triplet excited state generation is vital for many applications. Herein, we show Au and Pt nanoparticles as sensitizers for triplet generation in adjacent 9-anthracene carboxylic acid (ACA) molecules. Ultrafast spectroscopy reveals hole transfer from ACA to Au and Pt, with different time constants depending on the electronic structure of metal, followed by spin-flip in metal and charge recombination to produce triplet state (3ACA*). 3ACA* can transfer its energy to molecular oxygen to produce singlet oxygen (1O2), with quantum yields of 67.8% and 42.3% for Au-ACA and Pt-ACA, ∼3 and 2 times higher than that of free ACA, respectively. The nanoparticle-ACA nanohybrids show high antibacterial activity, attributed to the synergistic effect of nanoparticle enhanced 1O2 generation and photothermal effect from plasmonic hot carriers. This bifunctionality of metal nanoparticle-molecule nanohybrids is promising for many applications including photodynamic therapy and photocatalysis.
{"title":"Metal Nanoparticle Enhanced Molecular Triplet Generation for Singlet Oxygen Production and Antibacterial Application.","authors":"Zhanzhao Li,Ziwei Xu,Shaokuan Gong,Kaizhen Liu,Jin Yang,Xue Han,Niu Xu,Weiming Song,Xihan Chen,Jin-Hui Zhong","doi":"10.1021/acs.nanolett.5c05126","DOIUrl":"https://doi.org/10.1021/acs.nanolett.5c05126","url":null,"abstract":"Developing sensitizers for highly efficient molecular spin-triplet excited state generation is vital for many applications. Herein, we show Au and Pt nanoparticles as sensitizers for triplet generation in adjacent 9-anthracene carboxylic acid (ACA) molecules. Ultrafast spectroscopy reveals hole transfer from ACA to Au and Pt, with different time constants depending on the electronic structure of metal, followed by spin-flip in metal and charge recombination to produce triplet state (3ACA*). 3ACA* can transfer its energy to molecular oxygen to produce singlet oxygen (1O2), with quantum yields of 67.8% and 42.3% for Au-ACA and Pt-ACA, ∼3 and 2 times higher than that of free ACA, respectively. The nanoparticle-ACA nanohybrids show high antibacterial activity, attributed to the synergistic effect of nanoparticle enhanced 1O2 generation and photothermal effect from plasmonic hot carriers. This bifunctionality of metal nanoparticle-molecule nanohybrids is promising for many applications including photodynamic therapy and photocatalysis.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"224 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145728655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
As cathode materials for aqueous zinc-ion batteries (AZIBs), amorphous materials emerge as promising cathodes due to their isotropic ion diffusion pathways and abundant active sites. However, their intrinsically low electronic conductivity and irreversible crystallization during cycling exacerbate structural degradation, which severely degrades the cycling stability. To address this, we designed a novel cathode by integrating amorphous VOx nanospheres into a porous V2CTx MXene skeleton, creating ion/electron conduction highways that overcome the sluggish ion kinetics in crystalline cathodes and restricted interlayer electron transport in MXenes. In situ X-ray diffraction verifies that oxygen/fluorine-terminated MXene surfaces accelerate Zn2+ desolvation via hydrophobic F-group-mediated water repulsion. Composite electrode achieves 401 mAh g-1 (0.2 A g-1) and retains 140 mAh g-1 after 6500 cycles at 4 A g-1. A quasi-solid-state device with poly(vinyl alcohol) gel electrolyte achieves 97% capacity retention over 1200 cycles. This interface-bulk synergy guides AZIB cathode design, combining interfacial desolvation acceleration (MXene) with bulk-phase ion confinement (amorphous VOx).
无定形材料作为水基锌离子电池的正极材料，由于其具有各向同性的离子扩散途径和丰富的活性位点而成为极有前景的正极材料。然而，其固有的低电导率和循环过程中的不可逆结晶加剧了结构退化，严重降低了循环稳定性。为了解决这个问题，我们设计了一种新型阴极，将无定形的VOx纳米球集成到多孔的V2CTx MXene骨架中，创造了离子/电子传导高速公路，克服了晶体阴极中缓慢的离子动力学和MXene层间电子传输的限制。原位x射线衍射证实，氧/氟端MXene表面通过疏水f基团介导的水排斥加速Zn2+的脱溶。复合电极达到401 mAh g-1 (0.2 A g-1)，并在4a g-1下6500次循环后保持140 mAh g-1。使用聚乙烯醇凝胶电解质的准固态器件在1200次循环中实现97%的容量保持。这种界面-体协同作用指导了AZIB阴极的设计，结合了界面脱溶加速（MXene）和体相离子约束（非晶VOx）。
{"title":"Accelerating Zn2+ Desolvation and Diffusion via Interfacial Engineering in MXene/Amorphous VOx Composites for High-Stable Zn-Ion Batteries.","authors":"Guanyu Ma,Kerun Chen,Xintong Bu,Haowei Li,Gang Chen,Yu Gao","doi":"10.1021/acs.nanolett.5c04688","DOIUrl":"https://doi.org/10.1021/acs.nanolett.5c04688","url":null,"abstract":"As cathode materials for aqueous zinc-ion batteries (AZIBs), amorphous materials emerge as promising cathodes due to their isotropic ion diffusion pathways and abundant active sites. However, their intrinsically low electronic conductivity and irreversible crystallization during cycling exacerbate structural degradation, which severely degrades the cycling stability. To address this, we designed a novel cathode by integrating amorphous VOx nanospheres into a porous V2CTx MXene skeleton, creating ion/electron conduction highways that overcome the sluggish ion kinetics in crystalline cathodes and restricted interlayer electron transport in MXenes. In situ X-ray diffraction verifies that oxygen/fluorine-terminated MXene surfaces accelerate Zn2+ desolvation via hydrophobic F-group-mediated water repulsion. Composite electrode achieves 401 mAh g-1 (0.2 A g-1) and retains 140 mAh g-1 after 6500 cycles at 4 A g-1. A quasi-solid-state device with poly(vinyl alcohol) gel electrolyte achieves 97% capacity retention over 1200 cycles. This interface-bulk synergy guides AZIB cathode design, combining interfacial desolvation acceleration (MXene) with bulk-phase ion confinement (amorphous VOx).","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"11 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145728656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-11DOI: 10.1021/acs.nanolett.5c04627
Mark Potts, Shu Zhang
We propose using spin-qubit noise magnetometry to probe dynamical signatures of magnetic Berezinskii–Kosterlitz–Thouless (BKT) physics. For a nitrogen-vacancy (NV) center coupled to two-dimensional XY magnets, we predict distinctive features in the magnetic noise spectral density in the sub-MHz to GHz frequency range. In the quasi-long-range ordered phase, the spectrum exhibits a temperature-dependent power law characteristic of algebraic spin correlations. Above the transition, the noise reflects the proliferation of free vortices and enables quantitative extraction of the vortex conductivity, a key parameter of vortex transport. These results highlight NV as a powerful spectroscopic method to resolve magnetic dynamics in the mesoscopic and low-frequency regimes and to probe exotic magnetic phase transitions.
{"title":"Spin-Qubit Noise Spectroscopy of Magnetic Berezinskii–Kosterlitz–Thouless Physics","authors":"Mark Potts, Shu Zhang","doi":"10.1021/acs.nanolett.5c04627","DOIUrl":"https://doi.org/10.1021/acs.nanolett.5c04627","url":null,"abstract":"We propose using spin-qubit noise magnetometry to probe dynamical signatures of magnetic Berezinskii–Kosterlitz–Thouless (BKT) physics. For a nitrogen-vacancy (NV) center coupled to two-dimensional XY magnets, we predict distinctive features in the magnetic noise spectral density in the sub-MHz to GHz frequency range. In the quasi-long-range ordered phase, the spectrum exhibits a temperature-dependent power law characteristic of algebraic spin correlations. Above the transition, the noise reflects the proliferation of free vortices and enables quantitative extraction of the vortex conductivity, a key parameter of vortex transport. These results highlight NV as a powerful spectroscopic method to resolve magnetic dynamics in the mesoscopic and low-frequency regimes and to probe exotic magnetic phase transitions.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"39 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145732525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Harnessing nanoscale motor proteins to control material shape is a promising strategy in nanotechnology and material science. One notable system is the actomyosin network, composed of actin filaments and myosin motor proteins, providing a platform for constructing contractile, shape-adaptive materials. While the role of actomyosin in shaping cells has been studied, the reverse question of how the boundary shape affects the actomyosin system remains poorly understood. Here, we present a microwell system that reveals how geometrical confinement directs the organization of actomyosin networks. By combining experiments and simulations, we show that the asymmetric shape of the microwells is transferred to contracted actomyosin gels via actin flow, which propagates laterally and upward, leading to actomyosin accumulation at the top surface. Furthermore, tuning the myosin contractility and actin polymerization rate allows control over gel size and shape. Our findings provide a framework for integrating molecular motors and cytoskeletons into confined architectures to create responsive biomaterials.
{"title":"Myosin-Driven Advection and Actin Reorganization Control the Geometry of Confined Actomyosin Gel","authors":"Archit Negi, Ryota Sakamoto, Ryo Ienaga, Makito Miyazaki, Yusuke T. Maeda","doi":"10.1021/acs.nanolett.5c02558","DOIUrl":"https://doi.org/10.1021/acs.nanolett.5c02558","url":null,"abstract":"Harnessing nanoscale motor proteins to control material shape is a promising strategy in nanotechnology and material science. One notable system is the actomyosin network, composed of actin filaments and myosin motor proteins, providing a platform for constructing contractile, shape-adaptive materials. While the role of actomyosin in shaping cells has been studied, the reverse question of how the boundary shape affects the actomyosin system remains poorly understood. Here, we present a microwell system that reveals how geometrical confinement directs the organization of actomyosin networks. By combining experiments and simulations, we show that the asymmetric shape of the microwells is transferred to contracted actomyosin gels via actin flow, which propagates laterally and upward, leading to actomyosin accumulation at the top surface. Furthermore, tuning the myosin contractility and actin polymerization rate allows control over gel size and shape. Our findings provide a framework for integrating molecular motors and cytoskeletons into confined architectures to create responsive biomaterials.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"107 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145711461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Two-dimensional (2D) semiconductors are promising channel materials for next-generation transistors, but the integration of gate stacks with clean interfaces remains challenging. Here, we demonstrate that a high-quality gate stack, composed of a van der Waals gate metal and high-κ dielectric, could be prepared via partial oxidation of layered tantalum disulfide (TaS2), and integrated with 2D semiconductors through van der Waals assembly. This nondestructive and contamination-free process ensured atomically abrupt and impurity-free interfaces of the gate-electrode/dielectric and dielectric/semiconductor. The chemically converted TaOx displayed dielectric properties with a high dielectric constant of 28.6 and a breakdown field of 5 MV/cm. Top-gated 2D MoS2 FETs fabricated using the obtained TaOx/TaS2 heterostructure as gate stack exhibited an on/off current ratio over 107, a subthreshold swing down to 61.7 mV/decade and a gate leakage current below 50 fA. We also show that the TaOx/TaS2 gate stack could be used to construct high-gain (>90) 2D complementary inverters.
{"title":"Partially Oxidized TaS2 as a High-Quality Gate Stack for Two-Dimensional Transistors","authors":"Kejie Guan,Hao Dai,Fuqin Sun,Xiaoshuang Gou,Lin Liu,Yingyi Wang,Weifan Zhou,Yang Xia,Cheng Zhang,Xiaowei Wang,Ting Zhang","doi":"10.1021/acs.nanolett.5c05052","DOIUrl":"https://doi.org/10.1021/acs.nanolett.5c05052","url":null,"abstract":"Two-dimensional (2D) semiconductors are promising channel materials for next-generation transistors, but the integration of gate stacks with clean interfaces remains challenging. Here, we demonstrate that a high-quality gate stack, composed of a van der Waals gate metal and high-κ dielectric, could be prepared via partial oxidation of layered tantalum disulfide (TaS2), and integrated with 2D semiconductors through van der Waals assembly. This nondestructive and contamination-free process ensured atomically abrupt and impurity-free interfaces of the gate-electrode/dielectric and dielectric/semiconductor. The chemically converted TaOx displayed dielectric properties with a high dielectric constant of 28.6 and a breakdown field of 5 MV/cm. Top-gated 2D MoS2 FETs fabricated using the obtained TaOx/TaS2 heterostructure as gate stack exhibited an on/off current ratio over 107, a subthreshold swing down to 61.7 mV/decade and a gate leakage current below 50 fA. We also show that the TaOx/TaS2 gate stack could be used to construct high-gain (>90) 2D complementary inverters.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"67 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145717332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-10DOI: 10.1021/acs.nanolett.5c04821
Jun Jiang Luo,Jun Yu Long,Kuoran Xing,Glebert Cañete Dadol,Hao Lin Zou,Hong Qun Luo,Nian Bing Li,Hang Qian,David Tai Leong,Bang Lin Li
The geometric chirality of nanoscale materials originates from the asymmetric structures of the enantiomeric molecules. Herein, we introduce a universal strategy for fabricating in situ-synthesized Au nanostructures (issAu) on biological substrates using a simple staining solution of Au precursors, surfactant, and reductant. As a proof-of-concept, we integrated this staining reaction into bacterial systems, achieving the oriented growth of issAu on organism skeletons. With the involvement of exogenous cysteine enantiomers in the staining solution, enantiomeric molecules contribute to anisotropic growth of branched issAu and the evolution of plasmonic chirality. Through reaction optimization, we successfully engineer chiral issAu onto bacteria, constructing these nanobioheterostructures as versatile, bacterium-derived nanomaterials. The simple and rapid staining method based on chiral issAu growth solutions facilitates the in situ plasmonic engineering of pathogenic bacteria, enabling optical microscopy imaging of individual microbes. Our protocol provides an approach for the chiral nanoengineering of biological entities and exhibits high potential in antimicrobial and bioanalytical applications.
{"title":"Chiral Gold Staining Enables In Situ Plasmonic Engineering for Single-Bacterium Microscopic Imaging Analysis.","authors":"Jun Jiang Luo,Jun Yu Long,Kuoran Xing,Glebert Cañete Dadol,Hao Lin Zou,Hong Qun Luo,Nian Bing Li,Hang Qian,David Tai Leong,Bang Lin Li","doi":"10.1021/acs.nanolett.5c04821","DOIUrl":"https://doi.org/10.1021/acs.nanolett.5c04821","url":null,"abstract":"The geometric chirality of nanoscale materials originates from the asymmetric structures of the enantiomeric molecules. Herein, we introduce a universal strategy for fabricating in situ-synthesized Au nanostructures (issAu) on biological substrates using a simple staining solution of Au precursors, surfactant, and reductant. As a proof-of-concept, we integrated this staining reaction into bacterial systems, achieving the oriented growth of issAu on organism skeletons. With the involvement of exogenous cysteine enantiomers in the staining solution, enantiomeric molecules contribute to anisotropic growth of branched issAu and the evolution of plasmonic chirality. Through reaction optimization, we successfully engineer chiral issAu onto bacteria, constructing these nanobioheterostructures as versatile, bacterium-derived nanomaterials. The simple and rapid staining method based on chiral issAu growth solutions facilitates the in situ plasmonic engineering of pathogenic bacteria, enabling optical microscopy imaging of individual microbes. Our protocol provides an approach for the chiral nanoengineering of biological entities and exhibits high potential in antimicrobial and bioanalytical applications.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"22 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145711008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-10DOI: 10.1021/acs.nanolett.5c04582
Andreas Neusch,Christina Siepe,Liesa Zitzke,Alexandra C. Fux,Cornelia Monzel
Homopolymerization and cluster formation of cellular membrane receptors (MRs) are increasingly recognized as an essential facet of cell signaling and modulator of physiological responses. Yet, there is a lack of tools that can mediate precise stimulation to better understand the mechanisms and effects of clustering. Here, we designed fluorescent semisynthetic nanoparticles (NPs) based on the iron-storage protein ferritin and Staphylococcus aureus protein A to specifically target and activate distinct MRs, without causing side-effects. The NP exhibits high monodispersity and is readily equipped with a variety of antibodies with a KD value below 5 nM. Specificity of the NP antigen recognition was evaluated for cells expressing transferrin receptor 1 (TfR1) or the death receptor CD95, both of which displayed NP-mediated cluster formation. Finally, our engineered NP acts as a natural ligand for TfR1 and induces apoptosis signaling solely by CD95 cluster formation in a ligand-independent manner.
{"title":"Semisynthetic Ferritin Nanocages for Flexible, Site-Specific Targeting and Ligand-Free Activation of Membrane Receptors","authors":"Andreas Neusch,Christina Siepe,Liesa Zitzke,Alexandra C. Fux,Cornelia Monzel","doi":"10.1021/acs.nanolett.5c04582","DOIUrl":"https://doi.org/10.1021/acs.nanolett.5c04582","url":null,"abstract":"Homopolymerization and cluster formation of cellular membrane receptors (MRs) are increasingly recognized as an essential facet of cell signaling and modulator of physiological responses. Yet, there is a lack of tools that can mediate precise stimulation to better understand the mechanisms and effects of clustering. Here, we designed fluorescent semisynthetic nanoparticles (NPs) based on the iron-storage protein ferritin and Staphylococcus aureus protein A to specifically target and activate distinct MRs, without causing side-effects. The NP exhibits high monodispersity and is readily equipped with a variety of antibodies with a KD value below 5 nM. Specificity of the NP antigen recognition was evaluated for cells expressing transferrin receptor 1 (TfR1) or the death receptor CD95, both of which displayed NP-mediated cluster formation. Finally, our engineered NP acts as a natural ligand for TfR1 and induces apoptosis signaling solely by CD95 cluster formation in a ligand-independent manner.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"13 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145717331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-10DOI: 10.1021/acs.nanolett.5c05385
Yan Lv,Xueying Ma,Yao Xu,Jian Li,Wenheng Xu,Dawei Zhou,Congzhou Li,Fengrui Hu,Lin Wang,Xiaoyong Wang
Chiral ligand-functionalized perovskite nanocrystals (NCs) are promising sources of circularly polarized light, yet their intrinsic emissive behavior is often blurred by ensemble averaging, limiting mechanistic insights into chirality transfer. Here, by resolving individual emitters, single-NC spectroscopy unveils heterogeneity that complements ensemble measurements. Only a minority (∼22.2%) of NCs exhibit detectable chiroptical response, whereas rare emitters display circular polarization degrees approaching ∼48.0% while maintaining excellent single-photon purity of ∼95.0%. By disentangling fluorescence blinking and inhomogeneous broadening, we reveal that ligand chirality imprints distinct fingerprints on excitonic emission, including static energy splitting and dynamic asymmetry in radiative decay rates. These results provide direct evidence of the coupling between molecular chirality and NC band-edge emission states. Our findings underscore single-particle spectroscopy as an effective probe to identify emitter-specific behavior and offer fundamental insights for advancing chiral perovskite NCs toward efficient chiral quantum light sources.
{"title":"Single-Particle Insights into Circularly Polarized Emission from Chiral Ligand-Tailored Perovskite Nanocrystals.","authors":"Yan Lv,Xueying Ma,Yao Xu,Jian Li,Wenheng Xu,Dawei Zhou,Congzhou Li,Fengrui Hu,Lin Wang,Xiaoyong Wang","doi":"10.1021/acs.nanolett.5c05385","DOIUrl":"https://doi.org/10.1021/acs.nanolett.5c05385","url":null,"abstract":"Chiral ligand-functionalized perovskite nanocrystals (NCs) are promising sources of circularly polarized light, yet their intrinsic emissive behavior is often blurred by ensemble averaging, limiting mechanistic insights into chirality transfer. Here, by resolving individual emitters, single-NC spectroscopy unveils heterogeneity that complements ensemble measurements. Only a minority (∼22.2%) of NCs exhibit detectable chiroptical response, whereas rare emitters display circular polarization degrees approaching ∼48.0% while maintaining excellent single-photon purity of ∼95.0%. By disentangling fluorescence blinking and inhomogeneous broadening, we reveal that ligand chirality imprints distinct fingerprints on excitonic emission, including static energy splitting and dynamic asymmetry in radiative decay rates. These results provide direct evidence of the coupling between molecular chirality and NC band-edge emission states. Our findings underscore single-particle spectroscopy as an effective probe to identify emitter-specific behavior and offer fundamental insights for advancing chiral perovskite NCs toward efficient chiral quantum light sources.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"5 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145711037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-10DOI: 10.1021/acs.nanolett.5c05277
Michael H Stewart,Michael W Swift,Farwa Awan,Liam Burke,Christopher M Green,Barbara A Marcheschi,Igor L Medintz,Todd D Krauss,Alexander L Efros
Semiconductor nanoplatelets possess exceptional optical properties that make them promising candidates for next-generation optoelectronic applications. However, unlike quantum dots where absorption spectroscopy alone can determine both size and concentration, nanoplatelets present a significant characterization challenge: the absorption peak position reveals only thickness, providing no information about lateral dimensions or concentration. This limitation forces researchers to rely on time-consuming elemental analysis techniques for complete sample characterization. Here, we present an experimentally verified theoretical framework that predicts the frequency-dependent absorption coefficient of randomly oriented CdSe, CdS, and CdTe nanoplatelets, enabling concentration determination from absorption measurements and lateral size estimates. Our model shows that the integrated absorption coefficient depends universally on nanoplatelet surface area and thickness, yielding a practical tool to extract concentrations without laborious elemental analysis. This approach bridges the characterization gap between quantum dots and nanoplatelets, offering a streamlined method for sample analysis that could accelerate nanoplatelet research and applications.
{"title":"Extinction Coefficients of CdSe, CdS, and CdTe Nanoplatelets in Solution: A Practical Tool for Concentration Determination.","authors":"Michael H Stewart,Michael W Swift,Farwa Awan,Liam Burke,Christopher M Green,Barbara A Marcheschi,Igor L Medintz,Todd D Krauss,Alexander L Efros","doi":"10.1021/acs.nanolett.5c05277","DOIUrl":"https://doi.org/10.1021/acs.nanolett.5c05277","url":null,"abstract":"Semiconductor nanoplatelets possess exceptional optical properties that make them promising candidates for next-generation optoelectronic applications. However, unlike quantum dots where absorption spectroscopy alone can determine both size and concentration, nanoplatelets present a significant characterization challenge: the absorption peak position reveals only thickness, providing no information about lateral dimensions or concentration. This limitation forces researchers to rely on time-consuming elemental analysis techniques for complete sample characterization. Here, we present an experimentally verified theoretical framework that predicts the frequency-dependent absorption coefficient of randomly oriented CdSe, CdS, and CdTe nanoplatelets, enabling concentration determination from absorption measurements and lateral size estimates. Our model shows that the integrated absorption coefficient depends universally on nanoplatelet surface area and thickness, yielding a practical tool to extract concentrations without laborious elemental analysis. This approach bridges the characterization gap between quantum dots and nanoplatelets, offering a streamlined method for sample analysis that could accelerate nanoplatelet research and applications.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"11 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145711009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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