Pub Date : 2022-05-17DOI: 10.1088/2399-1984/ac7098
P. Saraswathi, Anjaly Babu, S. Ramarao, K. Uday Kumar, Hitesh Borkar, C. Rajesh, K. Kumar
Designing low-cost, Earth-abundant, and non-precious catalysts for electrochemical water oxidation reactions is particularly important for accelerating the development of sustainable energy sources and, further, can be fed to fuel cells. In the present work, we report the oxygen evolution reaction (OER) activity of a metal-oxide catalyst, Mn3O4, and study the effect of transition metal doping (Cu and Fe) on the OER activity of Mn3O4 in an alkaline medium. The Mn3O4 and transition metal (Cu and Fe) doped Mn3O4 catalysts were prepared using a hydrothermal reaction technique. Powder x-ray diffraction studies revealed that these compounds adopt a tetragonal spinel structure with an I41/amd space group, and this is further supported with Fourier transform infrared spectroscopic measurements. These results are further supported by high-resolution transmission electron microscopic measurements. The electrochemical measurements of these catalysts reveal that the transition metal (Cu and Fe) doped Mn3O4 catalysts show better OER activity than pristine Mn3O4 (MO). The transition metal (Cu and Fe) doped Mn3O4 catalysts exhibit lower overpotential for the OER (η MCO = 300 mV and η MFO = 240 mV) than the MO (η MO = 350 mV) catalyst. The better performance of Fe-doped Mn3O4 is further supported by turnover frequency calculations.
{"title":"Enhanced water oxidation reaction activity of Mn3O4 nanocrystals in an alkaline medium by doping transition-metal ions","authors":"P. Saraswathi, Anjaly Babu, S. Ramarao, K. Uday Kumar, Hitesh Borkar, C. Rajesh, K. Kumar","doi":"10.1088/2399-1984/ac7098","DOIUrl":"https://doi.org/10.1088/2399-1984/ac7098","url":null,"abstract":"Designing low-cost, Earth-abundant, and non-precious catalysts for electrochemical water oxidation reactions is particularly important for accelerating the development of sustainable energy sources and, further, can be fed to fuel cells. In the present work, we report the oxygen evolution reaction (OER) activity of a metal-oxide catalyst, Mn3O4, and study the effect of transition metal doping (Cu and Fe) on the OER activity of Mn3O4 in an alkaline medium. The Mn3O4 and transition metal (Cu and Fe) doped Mn3O4 catalysts were prepared using a hydrothermal reaction technique. Powder x-ray diffraction studies revealed that these compounds adopt a tetragonal spinel structure with an I41/amd space group, and this is further supported with Fourier transform infrared spectroscopic measurements. These results are further supported by high-resolution transmission electron microscopic measurements. The electrochemical measurements of these catalysts reveal that the transition metal (Cu and Fe) doped Mn3O4 catalysts show better OER activity than pristine Mn3O4 (MO). The transition metal (Cu and Fe) doped Mn3O4 catalysts exhibit lower overpotential for the OER (η MCO = 300 mV and η MFO = 240 mV) than the MO (η MO = 350 mV) catalyst. The better performance of Fe-doped Mn3O4 is further supported by turnover frequency calculations.","PeriodicalId":54222,"journal":{"name":"Nano Futures","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49367842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-16DOI: 10.1088/2399-1984/ac701d
Christian Harito, M. Khalil, N. L. W. Septiani, K. K. Dewi, A. Hardiansyah, B. Yuliarto, F. Walsh
Pandemics such as COVID-19 have highlighted the importance of point-of-care sensors for testing, tracing, and treatment to minimize and manage infection. Biosensors have been widely deployed in portable devices such as glucose sensors and pregnancy tests. Their development for point-of-exposure virus detection or point-of-care devices is anticipated but their reliability for the accurate detection of viruses is critical. Nanomaterials, such as metal nanoparticles (NPs), magnetic NPs, quantum dots, carbon-based nanomaterials, and molecularly imprinted polymer (MIP) NPs, have been utilized in biosensors to enhance sensitivity. Molecular imprinting is a cost-effective method to synthesize polymers for selective binding, which have excellent properties as biosensors. More research on MIP NPs can be expected in the near future. The utilization of nanomaterials in several types of transducers for biosensor devices is also illustrated to give an overview of their use. Finally, a summary is given together with a future perspective on how biosensors can be further developed as reliable, portable viral biosensors.
{"title":"Trends in nanomaterial-based biosensors for viral detection","authors":"Christian Harito, M. Khalil, N. L. W. Septiani, K. K. Dewi, A. Hardiansyah, B. Yuliarto, F. Walsh","doi":"10.1088/2399-1984/ac701d","DOIUrl":"https://doi.org/10.1088/2399-1984/ac701d","url":null,"abstract":"Pandemics such as COVID-19 have highlighted the importance of point-of-care sensors for testing, tracing, and treatment to minimize and manage infection. Biosensors have been widely deployed in portable devices such as glucose sensors and pregnancy tests. Their development for point-of-exposure virus detection or point-of-care devices is anticipated but their reliability for the accurate detection of viruses is critical. Nanomaterials, such as metal nanoparticles (NPs), magnetic NPs, quantum dots, carbon-based nanomaterials, and molecularly imprinted polymer (MIP) NPs, have been utilized in biosensors to enhance sensitivity. Molecular imprinting is a cost-effective method to synthesize polymers for selective binding, which have excellent properties as biosensors. More research on MIP NPs can be expected in the near future. The utilization of nanomaterials in several types of transducers for biosensor devices is also illustrated to give an overview of their use. Finally, a summary is given together with a future perspective on how biosensors can be further developed as reliable, portable viral biosensors.","PeriodicalId":54222,"journal":{"name":"Nano Futures","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2022-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44431043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-25DOI: 10.1088/2399-1984/ac6a31
Mohamed N Sanad, S. El-Dek, U. Eldemerdash, Mohamed M. ElFaham
Heavy metals are principal concomitant pollutants in industrial wastewaters, posing a serious threat to public health and the environment. Herein, we develop a novel strategy to produce a new nanocomposite formed from corn cobs (CCs) and magnetite as a nanomaterial for the simultaneous removal of Fe+2 and Ni+2. The as-prepared nanocomposite was systematically characterized by x-ray diffraction, field emission scanning electron microscopy, mapping, energy-dispersive x-ray spectroscopy, high-resolution transmission electron microscopy, selected area electron diffraction, zeta size, and zeta potential. Compared to the CCs and Fe3O4, the nanocomposite showed better adsorption performance. The maximum adsorption efficiency of the CC, Fe3O4, and the nanocomposite was calculated by atomic analysis to be around 91.84%, 91.28%, and 98.51%, respectively, under the same conditions. This study indicates that the nanocomposite could be a favorable biomass-derived adsorbent for the simultaneous removal of heavy metals.
{"title":"Study of the adsorptive removal of (Fe+2) and (Ni+2) from water by synthesized magnetite/corn cobs magnetic nanocomposite","authors":"Mohamed N Sanad, S. El-Dek, U. Eldemerdash, Mohamed M. ElFaham","doi":"10.1088/2399-1984/ac6a31","DOIUrl":"https://doi.org/10.1088/2399-1984/ac6a31","url":null,"abstract":"Heavy metals are principal concomitant pollutants in industrial wastewaters, posing a serious threat to public health and the environment. Herein, we develop a novel strategy to produce a new nanocomposite formed from corn cobs (CCs) and magnetite as a nanomaterial for the simultaneous removal of Fe+2 and Ni+2. The as-prepared nanocomposite was systematically characterized by x-ray diffraction, field emission scanning electron microscopy, mapping, energy-dispersive x-ray spectroscopy, high-resolution transmission electron microscopy, selected area electron diffraction, zeta size, and zeta potential. Compared to the CCs and Fe3O4, the nanocomposite showed better adsorption performance. The maximum adsorption efficiency of the CC, Fe3O4, and the nanocomposite was calculated by atomic analysis to be around 91.84%, 91.28%, and 98.51%, respectively, under the same conditions. This study indicates that the nanocomposite could be a favorable biomass-derived adsorbent for the simultaneous removal of heavy metals.","PeriodicalId":54222,"journal":{"name":"Nano Futures","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2022-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49039939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-21DOI: 10.1088/2399-1984/ac691c
Ran Wang, Miaomiao Ji, X. Jin, Qiran Zhang, T. Jiao
In recent years, the rational use and development of energy has become an important research direction. As a novel technology, triboelectric nanogenerators (TENGs) can effectively convert other energy from around the environment into electricity. TENGs have wide applicability due to their adjustable structures, but they are still limited to a certain extent in some special fields. For example, some special requirements for triboelectric materials need to be addressed when a TENG is applied in a high temperature environment, in water, in wind, or for human health. Therefore, this review introduces some TENGs applied in special environments, and provides a reference for the preparation and application of functional TENGs. It provides a new idea for the preparation of multifunctional TENGs and their wide application in various fields.
{"title":"Recent developments in functional triboelectric nanogenerators for flame-retardant, human health, and energy-harvesting fields: a crucial review","authors":"Ran Wang, Miaomiao Ji, X. Jin, Qiran Zhang, T. Jiao","doi":"10.1088/2399-1984/ac691c","DOIUrl":"https://doi.org/10.1088/2399-1984/ac691c","url":null,"abstract":"In recent years, the rational use and development of energy has become an important research direction. As a novel technology, triboelectric nanogenerators (TENGs) can effectively convert other energy from around the environment into electricity. TENGs have wide applicability due to their adjustable structures, but they are still limited to a certain extent in some special fields. For example, some special requirements for triboelectric materials need to be addressed when a TENG is applied in a high temperature environment, in water, in wind, or for human health. Therefore, this review introduces some TENGs applied in special environments, and provides a reference for the preparation and application of functional TENGs. It provides a new idea for the preparation of multifunctional TENGs and their wide application in various fields.","PeriodicalId":54222,"journal":{"name":"Nano Futures","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2022-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46025464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.1016/j.futures.2022.102938
Suzanna Törnroth, J. Day, Moritz F. Fürst, S. Mander
{"title":"Participatory Utopian Sketching: A Methodological Framework for Collaborative Citizen (Re)Imagination of Urban Spatial Futures","authors":"Suzanna Törnroth, J. Day, Moritz F. Fürst, S. Mander","doi":"10.1016/j.futures.2022.102938","DOIUrl":"https://doi.org/10.1016/j.futures.2022.102938","url":null,"abstract":"","PeriodicalId":54222,"journal":{"name":"Nano Futures","volume":"18 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80108028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.1016/j.futures.2022.102949
Kanang Kanatamaturapoj, Steven R. McGreevy, Natapol Thongplew, Motoki Akitsu, J. Vervoort, A. Mangnus, Kazuhiko Ota, Christoph D. D. Rupprecht, Norie Tamura, Maximillian Spiegelberg, Mai Kobayashi, S. Pongkijvorasin, S. Wibulpolprasert
{"title":"Constructing practice-oriented futures for sustainable urban food policy in Bangkok","authors":"Kanang Kanatamaturapoj, Steven R. McGreevy, Natapol Thongplew, Motoki Akitsu, J. Vervoort, A. Mangnus, Kazuhiko Ota, Christoph D. D. Rupprecht, Norie Tamura, Maximillian Spiegelberg, Mai Kobayashi, S. Pongkijvorasin, S. Wibulpolprasert","doi":"10.1016/j.futures.2022.102949","DOIUrl":"https://doi.org/10.1016/j.futures.2022.102949","url":null,"abstract":"","PeriodicalId":54222,"journal":{"name":"Nano Futures","volume":"2 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78827399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.1016/j.futures.2022.102951
Joseph Kantenbacher, Deidra Miniard, Nathan Geiger, Landon Yoder, S. Attari
{"title":"Young adults face the future of the United States: perceptions of its promise, perils, and possibilities","authors":"Joseph Kantenbacher, Deidra Miniard, Nathan Geiger, Landon Yoder, S. Attari","doi":"10.1016/j.futures.2022.102951","DOIUrl":"https://doi.org/10.1016/j.futures.2022.102951","url":null,"abstract":"","PeriodicalId":54222,"journal":{"name":"Nano Futures","volume":"16 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87871647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-01DOI: 10.1016/j.futures.2022.102939
E. Eriksson, Karl Hallding, K. Skånberg
{"title":"Ensuring representativity of scenario sets: the importance of exploring unknown unknowns","authors":"E. Eriksson, Karl Hallding, K. Skånberg","doi":"10.1016/j.futures.2022.102939","DOIUrl":"https://doi.org/10.1016/j.futures.2022.102939","url":null,"abstract":"","PeriodicalId":54222,"journal":{"name":"Nano Futures","volume":"91 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77649154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-03-31DOI: 10.1088/2399-1984/ac62e6
Manman Liu, Yue Ma, Xiaofeng Fan, D. J. Singh, W. Zheng
Graphdiyne (GDY)-based materials are carbon allotropes with a two-dimensional (2D) planar structure composed of diacetylene bonds (sp) and sp 2 hybridized carbons. Their unique geometrical and electronic structure give them excellent electrochemical properties. The larger specific surface area and ion-diffusion channels in pores can provide more storage sites for alkali metal ions and increase the diffusion rate of electrons and ions. Hence, GDY-based materials possess broad prospects in electrochemical energy storage and have gained more favor as anode materials for alkali ion batteries. Here, we have made a systematic summary of GDY-based materials and their derivatives, including the geometrical and electronic structures, synthesis, modifications, and storage mechanisms of Li+/Na+/K+, along with the applications in Li+/Na+/K+ batteries. In view of the current situation, the large-scale application of GDY-based materials as anodes in alkali ion batteries is still a great challenge. We hope that this work can provide a theoretical basis for GDY-based materials with superior performance, more convenient and safer preparation, and higher yield.
{"title":"Progress of graphdiyne-based materials for anodes of alkali metal ion batteries","authors":"Manman Liu, Yue Ma, Xiaofeng Fan, D. J. Singh, W. Zheng","doi":"10.1088/2399-1984/ac62e6","DOIUrl":"https://doi.org/10.1088/2399-1984/ac62e6","url":null,"abstract":"Graphdiyne (GDY)-based materials are carbon allotropes with a two-dimensional (2D) planar structure composed of diacetylene bonds (sp) and sp 2 hybridized carbons. Their unique geometrical and electronic structure give them excellent electrochemical properties. The larger specific surface area and ion-diffusion channels in pores can provide more storage sites for alkali metal ions and increase the diffusion rate of electrons and ions. Hence, GDY-based materials possess broad prospects in electrochemical energy storage and have gained more favor as anode materials for alkali ion batteries. Here, we have made a systematic summary of GDY-based materials and their derivatives, including the geometrical and electronic structures, synthesis, modifications, and storage mechanisms of Li+/Na+/K+, along with the applications in Li+/Na+/K+ batteries. In view of the current situation, the large-scale application of GDY-based materials as anodes in alkali ion batteries is still a great challenge. We hope that this work can provide a theoretical basis for GDY-based materials with superior performance, more convenient and safer preparation, and higher yield.","PeriodicalId":54222,"journal":{"name":"Nano Futures","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46668926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pancreatic cancer is a malignant tumor with a high mortality rate. The rich stroma in tumor tissue is a major barrier to drug penetration and tumor killing. Cisplatin and cisplatin-based nano-delivery systems are widely used as chemotherapeutic agents. However, the side effects and the inability of permeating tumor tissue in depth have limited their application in the clinic. Hyaluronan is an important component of the extracellular matrix in the tumor tissue and has the potential to be targeted for tumor stroma degradation. Therefore, a nanocarrier-mediated cisplatin co-delivery system BPEI-SS-Pt/HAase@CaP consisting of hyaluronidase (HAase) and polymer-cisplatin conjugate BPEI-SS-Pt through disulfide bonding to branched polyethyleneimine (BPEI) was constructed. In the construction of the co-delivery system of BPEI-SS-Pt and HAase, amorphous calcium phosphate is introduced to obtain the tumor microenvironment responsive release of HAase. The particle size of optimized BPEI-SS-Pt/HAase@CaP nano-complexes is 143 ± 14 nm. In the tumor microenvironment, BPEI-SS-Pt/HAase@CaP nano-complexes were able to release HAase to degrade the hyaluronan in the tumor stroma. The results of histochemical and fluorescent labeling showed that hyaluronan was degraded in vivo by BPEI-SS-Pt/HAase@CaP and the nanocarrier-mediated BPEI-SS-Pt can be easily across the loosened stroma and penetrated the tumor tissue more deeply compared with BPEI-SS-Pt without loading HAase. When they were uptaken into tumor cells and responded to high glutathione in the intracellular environment to release cisplatin, more effective chemotherapy to pancreatic cancer was obtained. Compared with the free cisplatin or BPEI-SS-Pt group, BPEI-SS-Pt/HAase@CaP nano-complexes achieved the best antitumor effect in vivo, promising the future clinic use of cisplatin for effective chemotherapy to pancreatic cancer.
癌症是一种死亡率较高的恶性肿瘤。肿瘤组织中丰富的基质是药物渗透和肿瘤杀伤的主要屏障。基于顺铂和顺铂的纳米递送系统被广泛用作化疗剂。然而，副作用和不能深入渗透肿瘤组织限制了其在临床上的应用。透明质酸是肿瘤组织中细胞外基质的重要成分，有可能成为肿瘤基质降解的靶点。因此，纳米载体介导的顺铂共递送系统BPEI SS Pt/HAase@CaP构建了由透明质酸酶（HAase）和聚合物-顺铂偶联物BPEI-SS-Pt通过二硫键与支链聚乙烯亚胺（BPEI）形成的复合物。在BPEI SS Pt和HAase共递送系统的构建中，引入无定形磷酸钙以获得HAase的肿瘤微环境响应性释放。优化后的BPEI SS Pt的粒径/HAase@CaP纳米配合物为143±14nm。在肿瘤微环境中，BPEI SS Pt/HAase@CaP纳米复合物能够释放HAase以降解肿瘤基质中的透明质酸。组织化学和荧光标记结果表明，BPEI SS Pt在体内降解透明质酸/HAase@CaP并且与没有负载HAase的BPEI SS Pt相比，纳米载体介导的BPEI SS-Pt可以容易地穿过疏松的基质并更深入地穿透肿瘤组织。当它们被吸收到肿瘤细胞中，并在细胞内环境中对高谷胱甘肽产生反应以释放顺铂时，获得了对胰腺癌症更有效的化疗。与游离顺铂或BPEI SS Pt组相比/HAase@CaP纳米复合物在体内获得了最佳的抗肿瘤效果，有望在临床上应用顺铂对癌症进行有效的化疗。
{"title":"Construction of tumor microenvironment and redox responsive nanocarrier-mediated cisplatin co-delivery system for effective chemotherapy to pancreatic cancer","authors":"Zhou Jia, Hao Zhou, L. Hou, Fang Kou, Tang‐Rui Zhang, Baohua Wang, Wei Wang, Si-Yuan Zhou, Bang-le Zhang","doi":"10.1088/2399-1984/ac61f7","DOIUrl":"https://doi.org/10.1088/2399-1984/ac61f7","url":null,"abstract":"Pancreatic cancer is a malignant tumor with a high mortality rate. The rich stroma in tumor tissue is a major barrier to drug penetration and tumor killing. Cisplatin and cisplatin-based nano-delivery systems are widely used as chemotherapeutic agents. However, the side effects and the inability of permeating tumor tissue in depth have limited their application in the clinic. Hyaluronan is an important component of the extracellular matrix in the tumor tissue and has the potential to be targeted for tumor stroma degradation. Therefore, a nanocarrier-mediated cisplatin co-delivery system BPEI-SS-Pt/HAase@CaP consisting of hyaluronidase (HAase) and polymer-cisplatin conjugate BPEI-SS-Pt through disulfide bonding to branched polyethyleneimine (BPEI) was constructed. In the construction of the co-delivery system of BPEI-SS-Pt and HAase, amorphous calcium phosphate is introduced to obtain the tumor microenvironment responsive release of HAase. The particle size of optimized BPEI-SS-Pt/HAase@CaP nano-complexes is 143 ± 14 nm. In the tumor microenvironment, BPEI-SS-Pt/HAase@CaP nano-complexes were able to release HAase to degrade the hyaluronan in the tumor stroma. The results of histochemical and fluorescent labeling showed that hyaluronan was degraded in vivo by BPEI-SS-Pt/HAase@CaP and the nanocarrier-mediated BPEI-SS-Pt can be easily across the loosened stroma and penetrated the tumor tissue more deeply compared with BPEI-SS-Pt without loading HAase. When they were uptaken into tumor cells and responded to high glutathione in the intracellular environment to release cisplatin, more effective chemotherapy to pancreatic cancer was obtained. Compared with the free cisplatin or BPEI-SS-Pt group, BPEI-SS-Pt/HAase@CaP nano-complexes achieved the best antitumor effect in vivo, promising the future clinic use of cisplatin for effective chemotherapy to pancreatic cancer.","PeriodicalId":54222,"journal":{"name":"Nano Futures","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49366088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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