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Sustainability of drug discovery, development and use as embedded in European pharmaceutical policies 将药物发现、开发和使用的可持续性纳入欧洲制药政策
IF 9.3 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-04-11 DOI: 10.1016/j.cogsc.2025.101028
Bart De Spiegeleer, Evelien Wynendaele
Sustainability has become a key consideration across all sectors of society, from the automotive and finance industries to marketing, the food supply chain, and academia, with the pharmaceutical industry following suit. This review examines recent advancements in environmental and socio-economic sustainability within the pharmaceutical sector, with a particular emphasis on Europe, a leader in sustainable practices in pharma and biotech. Given the highly regulated nature of the pharmaceutical industry, its life cycle is significantly shaped by legal frameworks. Therefore, this review also delves into current EU policies and proposals that influence pharmaceutical sustainability.
从汽车和金融行业到营销、食品供应链和学术界,可持续性已经成为社会各个领域的关键考虑因素,制药行业也紧随其后。本综述审查了制药部门在环境和社会经济可持续性方面的最新进展,特别强调了制药和生物技术领域可持续实践的领导者欧洲。鉴于制药业的高度管制性质,其生命周期在很大程度上受到法律框架的影响。因此,本综述还深入研究了影响制药可持续性的当前欧盟政策和建议。
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引用次数: 0
Inorganic and organic syntheses in plasma-liquid systems for green chemistry applications 等离子体-液体系统中无机和有机合成的绿色化学应用
IF 9.3 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-04-10 DOI: 10.1016/j.cogsc.2025.101029
Anton Nikiforov , Yury Gorbanev , Nathalie De Geyter , Rino Morent , Annemie Bogaerts
The chemical industry is one of the main driving forces supporting the fast-growing population on our planet. Due to the extensive use of fossil fuels and large quantities of waste, chemical production often has a detrimental environmental impact. Sustainable and green technological processes based on renewable energy sources are sought-after to replace the currently used conventional wet chemistry. We present an overview of the recent advances and perspectives in plasma-liquid systems used for sustainable chemical synthesis, with emphasis on the engineering of inorganic nanomaterials and preparative organic synthesis.
化学工业是支持地球上快速增长的人口的主要驱动力之一。由于化石燃料的广泛使用和大量的废物,化学生产往往对环境产生有害影响。基于可再生能源的可持续和绿色技术过程正在寻求取代目前使用的传统湿化学。我们概述了用于可持续化学合成的等离子体-液体系统的最新进展和前景,重点介绍了无机纳米材料的工程和制备性有机合成。
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引用次数: 0
Recent advances on carbon-based nanocomposite membranes in water and wastewater applications 碳基纳米复合膜在水处理中的应用进展
IF 9.3 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-04-01 DOI: 10.1016/j.cogsc.2025.101026
Soheil Zarghami , Toraj Mohammadi
In today's industrial world, population growth and increased industrial production have intensified the need for potable water supply and effective wastewater treatment. Due to environmental concerns, advancements in separation processes have also become necessary. Membrane processes are particularly effective in removing contaminants from entering effluents, thereby protecting water sources, and are high-performance techniques for water and wastewater treatment. The synergistic effect of carbon-based nanocomposite membranes, resulting from the properties of carbon based nanomaterials (CBNs) (such as carbon nanotubes (CNTs) and, graphene oxide (GO)) combined with the unique characteristics of membrane separation techniques, has led to improved performance of the membrane processes. The classification of the content is based on the dimensions of CBNs and membranes: zero-dimensional (0D), one-dimensional (1D) and two-dimensional (2D). Efforts have been made to review articles from the past two years. This study briefly reviews newly developed membranes using carbon nanomaterials in various membrane technologies, including microfiltration (MF), ultrafiltration (UF), nanofiltration (NF), reverse osmosis (RO), forward osmosis (FO), membrane bioreactor (MBR), and membrane distillation (MD), aiming to highlight their potential success.
在今天的工业世界中,人口增长和工业生产的增加加剧了对饮用水供应和有效废水处理的需求。由于对环境的关注,分离工艺的进步也变得必要。膜处理在去除进入污水的污染物,从而保护水源方面特别有效,是水和废水处理的高性能技术。由于碳基纳米材料(如碳纳米管(CNTs)和氧化石墨烯(GO))的特性与膜分离技术的独特特性相结合,碳基纳米复合膜的协同效应导致了膜工艺性能的提高。内容的分类是基于cbn和膜的尺寸:零维(0D),一维(1D)和二维(2D)。我们已经努力审查过去两年的文章。本文简要介绍了近年来利用碳纳米材料制备膜的各种膜技术,包括微滤(MF)、超滤(UF)、纳滤(NF)、反渗透(RO)、正渗透(FO)、膜生物反应器(MBR)和膜蒸馏(MD)等,旨在突出其潜在的成功。
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引用次数: 0
Recent advances in upcycling lignocellulosic biomass through chemoenzymatic processes 通过化学酶过程升级回收木质纤维素生物质的最新进展
IF 9.3 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-03-28 DOI: 10.1016/j.cogsc.2025.101017
Guang Yang, Xin Li, Wang Ma, Xiaoman Sun, He Huang
Lignocellulosic biomass (LCB) has long been treated as easily available and low-cost renewable source to produce value-added chemicals. Enzymatic and chemical catalysis have long been applied for valorization of LCB. However, the intrinsic limitations of enzymatic/chemical catalysis hinder the practical application of LCB. Therefore, integrating both catalysts could be a promising strategy to overcome the drawbacks of single system. In this review, we focus on the recent advances in utilizing and upgrading lignocellulosic biomass through combined chemoenzymatic processes. The chemoenzymatic synthetic processes of furan derivatives, aromatic compounds, and other value-added chemicals starting from raw LCB or LCB-derived platform compounds are highlighted. Further, the limitations and future perspectives are discussed to facilitate the future research.
长期以来,木质纤维素生物质(LCB)一直被视为易于获得和低成本的可再生能源,用于生产增值化学品。长期以来,酶催化和化学催化一直被应用于LCB的增值。然而,酶/化学催化的内在局限性阻碍了LCB的实际应用。因此,将两种催化剂整合在一起是克服单一体系缺点的一种很有前途的策略。在这篇综述中,我们重点介绍了通过化学-酶联合工艺利用和升级木质纤维素生物质的最新进展。强调了从原料LCB或LCB衍生平台化合物开始的呋喃衍生物,芳香族化合物和其他增值化学品的化学酶合成过程。在此基础上,对研究的局限性和未来展望进行了讨论,以促进未来的研究。
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引用次数: 0
The effects of feedstock types and their properties on hydrothermal carbonisation and resulting hydrochar: A review 原料类型及其性质对水热炭化及生成的烃类的影响综述
IF 9.3 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-03-24 DOI: 10.1016/j.cogsc.2025.101024
Vigneshwaran Shanmugam , Elif Kaynak , Oisik Das , Lokesh P. Padhye
Hydrothermal carbonisation (HTC) technology benefits the environment by lowering greenhouse gas emissions and promoting sustainable waste management practices while supporting circular economy principles. Over the past two years, research has focused on optimising HTC process parameters, broadening the range of suitable feedstocks, and enhancing the properties of hydrochar and byproducts. This review discusses the characteristics of the hydrochar, including its calorific value, surface area, and nutrient content, and the influence of these parameters by feedstock type in the HTC. Furthermore, it reviews the suitability of hydrochar derived from different feedstocks in applications such as renewable solid fuel, soil amendment and environmental remediation. By analysing the most recent research advancements and identifying the associated challenges, this review underscores the importance of HTC in promoting sustainable waste management practices and enhancing resource utilisation in a circular economy framework.
水热碳化(HTC)技术可降低温室气体排放,促进可持续废物管理实践,同时支持循环经济原则,从而造福环境。在过去两年中,研究的重点是优化 HTC 工艺参数、扩大适用原料的范围以及提高水煤碳和副产品的特性。本综述讨论了氢碳的特性,包括其热值、表面积和营养成分,以及这些参数在氢化炭化过程中对原料类型的影响。此外,还回顾了从不同原料中提取的水炭在可再生固体燃料、土壤改良和环境修复等应用中的适用性。通过分析最新研究进展和确定相关挑战,本综述强调了氢化碳在循环经济框架下促进可持续废物管理实践和提高资源利用率的重要性。
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引用次数: 0
Reactor design in plasma-liquid systems for wastewater treatment 污水处理等离子体-液体系统的反应器设计
IF 9.3 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-03-19 DOI: 10.1016/j.cogsc.2025.101023
Selma Mededovic Thagard
Low-temperature plasmas (LTPs) represent a promising yet often controversial technology for water treatment that offer unique capabilities for degrading persistent contaminants. Despite demonstrated success at both bench and pilot scales, LTP-based treatment faces skepticism due to perceptions of high energy consumption and limited scalability compared to other advanced oxidation processes.
This opinion piece advocates for a strategic reorientation in plasma research, urging the scientific community to prioritize the study of relevant contaminants and realistic water matrices while applying chemical engineering principles to systematically describe these systems and develop universal laws guiding plasma reactor design for water treatment. Modular reactor arrangements, pre-concentration strategies, real-world testing, and a clear understanding of how contaminant type (surfactant vs. non-surfactant) influences reactor design are essential for advancing LTP technology beyond proof-of-concept studies. To achieve commercial viability, research must transition from trial-and-error approaches to systematic investigations integrating plasma physics, chemistry, and engineering.
低温等离子体(LTPs)是一种很有前途但经常引起争议的水处理技术,它具有降解持久性污染物的独特能力。尽管在实验和中试规模上都取得了成功,但与其他高级氧化工艺相比,基于ltp的处理面临着高能耗和有限的可扩展性的质疑。这篇观点文章提倡等离子体研究的战略重新定位,敦促科学界优先考虑相关污染物和现实水基质的研究,同时应用化学工程原理系统地描述这些系统,并制定指导水处理等离子体反应器设计的普遍规律。模块化反应器布置、预浓缩策略、实际测试以及对污染物类型(表面活性剂与非表面活性剂)如何影响反应器设计的清晰理解,对于推进LTP技术超越概念验证研究至关重要。为了实现商业可行性,研究必须从试错法过渡到整合等离子体物理、化学和工程的系统研究。
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引用次数: 0
Landfill gas to energy beyond an age of waste: A review of research trends 垃圾填埋气转化为能源,超越废物时代:研究趋势综述
IF 9.3 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-03-19 DOI: 10.1016/j.cogsc.2025.101019
Sinem Erdoğdu
Landfilling is the most applied waste disposal method worldwide. Landfill gas, which is nearly fifty percent methane, emitted by landfills, is one of the major contributors to global greenhouse gas emissions. Converting landfill gas to energy decreases landfill emissions while generating renewable energy. This article discusses trends in Landfill Gas-to-Energy (LFGTE) research between 2022 and 2025 based on recurrent themes in conventional and innovative LFGTE technology.
垃圾填埋是全世界最常用的废物处理方法。垃圾填埋场排放的填埋气中有近 50% 是甲烷,是全球温室气体排放的主要来源之一。将垃圾填埋气转化为能源可减少垃圾填埋气的排放,同时产生可再生能源。本文根据垃圾填埋气转化能源(LFGTE)的传统和创新技术中反复出现的主题,讨论了 2022 年至 2025 年垃圾填埋气转化能源(LFGTE)的研究趋势。
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引用次数: 0
Sustainable development at the crossroads: Navigating eco-humanism and eco-modernism 十字路口上的可持续发展:驾驭生态人文主义与生态现代主义
IF 9.3 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-03-15 DOI: 10.1016/j.cogsc.2025.101018
Muhammad Hassan Javed , Anees Ahmad , Abdul-Sattar Nizami , Massimo Gastaldi , Idiano D'Adamo
This review examines theoretical and practical tensions between eco-humanism and eco-modernism, two frameworks for sustainable development. In eco-humanism, humans are considered close to nature and promote ethical stewardship and community-based sustainability efforts. In contrast, eco-modernism emphasises technological advancements that can solve environmental problems while sustaining economic growth. It discusses the synergies and contradictions that result from such opposite ideologies. Initiatives like renewable energy projects and precision agriculture show synergies between technological development and social equity targets. However, there are contradictions when technological solutions bypass ethical considerations, as in large-scale projects without community consultation. The review also considers how to integrate these frameworks, where priorities differ, and technological optimism might overshadow necessary behavior changes. It demonstrates how interdisciplinarity in research, inclusive education, and policymaking can close the gap between eco-humanism and eco-modernism. This paper concludes that human-centred ethics combined with technological innovation constitute a viable way forward towards sustainable development. By embracing both ideologies, future sustainability efforts can be more inclusive, just, and effective in tackling global environmental and social problems.
本文考察了生态人文主义和生态现代主义这两个可持续发展框架在理论和实践上的紧张关系。在生态人文主义中,人类被认为是接近自然的,并促进道德管理和以社区为基础的可持续发展努力。相比之下,生态现代主义强调的是能够在维持经济增长的同时解决环境问题的技术进步。讨论了这种对立的意识形态所产生的协同作用和矛盾。可再生能源项目和精准农业等举措显示了技术发展与社会公平目标之间的协同效应。然而,当技术解决方案绕过伦理考虑时,就会出现矛盾,比如在没有征求社区意见的大型项目中。审查还考虑了如何整合这些框架,其中优先事项不同,技术乐观主义可能掩盖了必要的行为改变。它展示了跨学科研究、全纳教育和政策制定如何缩小生态人文主义和生态现代主义之间的差距。本文认为,以人为本的伦理与技术创新相结合是实现可持续发展的一条可行之路。通过拥抱这两种意识形态,未来的可持续发展努力可以更加包容、公正和有效地解决全球环境和社会问题。
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引用次数: 0
Cooperative chemoenzymatic approaches to transforming CO2 into high-value products 将二氧化碳转化为高价值产品的合作化学酶方法
IF 9.3 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-03-12 DOI: 10.1016/j.cogsc.2025.101016
Jianming Liu , Xiaowen Xia , Aocong Guan , Anping Zeng
Cooperative chemoenzymatic catalysis, combining the strengths of chemical and enzymatic reactions, has emerged as a powerful strategy for advancing innovative biomanufacturing platforms leveraging CO2 as a feedstock. This approach enables the synthesis of value-added molecules and materials from abundant low-carbon resources. In this review, we first highlight the critical role that chemoenzymatic reactions play in prebiotic chemistry, offering valuable insights into the design of complex biomolecules from simple precursors. We then examine the opportunities within chemoenzymatic synthesis through prominent examples: the ancient formose reaction followed by biotransformation, the electrochemical conversion of CO2 into energetic C1 and C2 compounds with subsequent enzymatic conversions for producing long carbon-chain products, the regeneration of energetic molecules such as ATP and NAD(P)H cofactors, and the integration of chemoenzymatic reactions in carbon-chain elongation and downstream purification processes. This synergistic approach not only maximizes the utility of CO2 as a feedstock but also contributes to the development of sustainable and efficient methods for CO2 utilization, advancing the fields of green chemistry and sustainable industrial practices.
合作化学酶催化结合了化学反应和酶反应的优势,已成为利用二氧化碳作为原料推进创新生物制造平台的有力策略。这种方法可以利用丰富的低碳资源合成高附加值的分子和材料。在这篇综述中,我们首先强调了化学酶促反应在前生物化学中发挥的关键作用,为从简单前体设计复杂生物分子提供了宝贵的见解。然后,我们通过一些突出的例子来探讨化学合成中的机遇:古老的甲糖反应后的生物转化、电化学将二氧化碳转化为高能 C1 和 C2 化合物并随后进行酶转化以生产长碳链产品、高能分子(如 ATP 和 NAD(P)H 辅因子)的再生,以及化学合成反应在碳链延长和下游纯化过程中的整合。这种协同方法不仅能最大限度地利用二氧化碳作为原料,还有助于开发可持续和高效的二氧化碳利用方法,推动绿色化学和可持续工业实践领域的发展。
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引用次数: 0
Pyridine dicarboxylic acid derived polyesters: Prospects for developing safe, circular and sustainable materials 吡啶二羧酸衍生聚酯:开发安全、循环和可持续材料的前景
IF 9.3 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-03-04 DOI: 10.1016/j.cogsc.2025.101014
Shanmugam Thiyagarajan
The use of aromatic chemicals as key ingredients in (bulk) applications such as coatings, paints, and packaging materials is inevitable. The high dependency on the aromatics is due to their rigid characteristics that offer enhanced properties resulting in superior application performance. The development of biobased aromatic chemicals (drop-in's) or renewable rigid alternatives is necessary for the transition towards sustainable products and to alleviate society's reliance on fossil feedstock primarily being used to produce such aromatic chemicals. This mini-review highlights the potential of renewable rigid pyridine dicarboxylic acid building blocks in producing polyesters with intriguing properties for various applications.
在涂料、油漆和包装材料等(散装)应用中,芳香化学品作为关键成分的使用是不可避免的。对芳烃的高度依赖是由于它们的刚性特性提供了增强的性能,从而产生了优越的应用性能。开发生物基芳香化学品(替代产品)或可再生的刚性替代品对于向可持续产品过渡以及减轻社会对主要用于生产此类芳香化学品的化石原料的依赖是必要的。这篇综述强调了可再生刚性吡啶二羧酸构建块在生产各种应用的聚酯方面的潜力。
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引用次数: 0
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Current Opinion in Green and Sustainable Chemistry
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