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Harnessing Fe(II)/α-ketoglutarate-dependent oxygenases for sustainable synthesis 利用铁(II)/α-酮戊二酸依赖的加氧酶进行可持续合成
IF 9.4 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2026-04-01 Epub Date: 2026-02-13 DOI: 10.1016/j.cogsc.2026.101059
Huibin Wang , Takahiro Mori , Ikuro Abe
Fe(II)/α-ketoglutarate-dependent oxygenases (αKG OXs) have emerged as versatile biocatalysts for selective C–H functionalization, offering sustainable routes to complex molecules under mild conditions. Recent advances in data-driven enzyme discovery, machine learning (ML)-guided enzyme engineering, and computational design have significantly improved their substrate scope, stability, and scalability for pharmaceutical synthesis. Beyond native oxidative modifications, repurposed αKG OXs mediate new-to-nature transformations, including site-selective azidation, Mukaiyama hydration, Conia-ene cyclization, and photoenzymatic cross-coupling. Their integration into chemoenzymatic cascades has enabled concise and green syntheses of complex natural products and drug intermediates. This review highlights recent advances in studies that establish αKG OXs as key enzymes for sustainable biocatalytic synthesis.
铁(II)/α-酮戊二酸依赖加氧酶(αKG OXs)已成为选择性C-H功能化的多功能生物催化剂,在温和条件下为复杂分子提供可持续的途径。数据驱动酶发现、机器学习(ML)指导酶工程和计算设计的最新进展显著改善了药物合成的底物范围、稳定性和可扩展性。除了天然氧化修饰之外,重新利用的αKG氧介导新的自然转化,包括位点选择性叠氮化,Mukaiyama水化,Conia-ene环化和光酶交叉偶联。它们整合到化学酶级联中,使得复杂的天然产物和药物中间体的简洁和绿色合成成为可能。本文综述了αKG OXs作为可持续生物催化合成关键酶的最新研究进展。
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引用次数: 0
Water-enabled organometallic and enzymatic catalysis: Sustainable technologies supporting API manufacturing 水催化有机金属和酶催化:支持原料药制造的可持续技术
IF 9.4 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2026-02-01 Epub Date: 2026-01-07 DOI: 10.1016/j.cogsc.2025.101058
Alessandra Tolomelli, Tommaso Fantoni, Davide Carboni, Lucia Ferrazzano, Walter Cabri
Aqueous chemistry is a key platform for advancing sustainable organometallic and enzymatic catalytic technologies relevant to API manufacturing. Effective implementation requires minimizing process mass intensity (PMI), increasing reaction mass efficiency, ensuring final product quality, and managing the impact of water-waste contaminants. Recent advances in palladium cross-coupling show how water or aqueous cosolvents can deliver highly efficient transformations: micellar water/sodium dodecyl sulfate/cyclopentylmethyl ether systems with new monodentate basic phosphines enable 0.125–0.5 mol% Pd and PMIs near 20 on complex architecture, while bidentate nitrogen ligands in hydroxyethyl pyrrolidone/water achieve 0.1–0.005 mol% Pd, turnover numbers up to 17,800, and >90% Pd recovery. Enzymatic innovations, including Merck’s free-enzyme cascade for islatravir and subtilisin-engineered peptide ligation for liraglutide, demonstrate how aqueous biocatalysis can provide selective, scalable, and greener API-relevant processes.
水化学是推进与原料药制造相关的可持续有机金属和酶催化技术的关键平台。有效的实施需要最小化过程质量强度(PMI),提高反应质量效率,确保最终产品质量,并管理废水污染物的影响。钯交叉偶联的最新进展表明,水或含水共溶剂如何实现高效转化:胶束水/十二烷基硫酸钠/环戊基甲基醚体系具有新的单齿碱性膦,可实现0.125-0.5 mol% Pd,复杂结构的PMIs接近20,而双齿氮配体在羟乙基吡咯烷酮/水中实现0.1-0.005 mol% Pd,周转率高达17,800,Pd回收率为90%。酶的创新,包括默克的islatravir的自由酶级联和利拉鲁肽的枯草素工程肽连接,证明了水生物催化如何提供选择性、可扩展和更环保的api相关工艺。
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引用次数: 0
Recycling and reuse of olefinic separators in lithium-ion batteries: A mini review 锂离子电池中烯烃分离器的回收和再利用:综述
IF 9.4 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-12-01 Epub Date: 2025-10-25 DOI: 10.1016/j.cogsc.2025.101054
Himanshu Gupta, N. Raveendran Shiju
The rapid expansion of lithium-ion battery (LIB) applications over the past decade—driven by the rise in portable electronics and electric vehicles—has led to a significant increase in battery waste. While the recovery of valuable metals such as lithium and cobalt from spent LIBs has received considerable attention, the recycling of separator materials remains largely neglected. These separators, typically made from polyethylene (PE) and polypropylene (PP), are critical to battery function yet are often discarded through landfilling, raising environmental concerns due to their non-biodegradable nature. This mini-review highlights the emerging need to address the end-of-life management of LIB separators, discusses recent advances in their reuse and recycling, and outlines potential pathways to incorporate these materials into circular economy models. Greater focus on separator recovery could enhance the overall sustainability and resource efficiency of LIB recycling processes.
在过去十年中,由于便携式电子产品和电动汽车的兴起,锂离子电池(LIB)的应用迅速扩大,导致电池浪费显著增加。虽然从废lib中回收锂和钴等有价金属受到了相当大的关注,但隔膜材料的回收在很大程度上仍然被忽视。这些隔膜通常由聚乙烯(PE)和聚丙烯(PP)制成,对电池功能至关重要,但由于其不可生物降解的性质,往往被垃圾填埋,引起了环境问题。这篇小型综述强调了解决LIB分离器报废管理的新需求,讨论了它们的再利用和回收的最新进展,并概述了将这些材料纳入循环经济模型的潜在途径。更多地关注分离器回收可以提高LIB回收过程的整体可持续性和资源效率。
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引用次数: 0
Recent advancements in solid-state ammonia sorbents 固态氨吸附剂的最新进展
IF 9.4 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-12-01 Epub Date: 2025-10-24 DOI: 10.1016/j.cogsc.2025.101050
Janna Attari , Valentina Mendoza Martinez , Farid Akhtar , Anastasiia Karabanova
The growing ammonia demand and the need to mitigate its toxicity have raised interest in solid-state ammonia sorbents as a safe alternative to conventional storage systems. This review paper focuses on the development of ammonia storage and thermochemical energy storage, based on research published from 2022 to 2024. Results demonstrate that the two applications have reached different technologies’ maturity. For ammonia storage, the aim was to enhance the sorbent’s performance by novel synthesis routes, whereas a recent shift toward the optimization of systems has been observed for energy storage applications. In our opinion, one should aim for a simplification of the sorbent synthesis route while keeping a look at novel developments to combine the enhancement of both efficiency and stability.
日益增长的氨需求和减轻其毒性的需要引起了人们对固态氨吸附剂作为传统储存系统的安全替代品的兴趣。本文以2022年至2024年发表的研究成果为基础,重点介绍了氨储存和热化学储能的发展。结果表明,这两种应用达到了不同的技术成熟度。对于氨储存,目的是通过新的合成路线来提高吸附剂的性能,而最近已经观察到储能应用中系统优化的转变。在我们看来,人们应该以简化吸附剂合成路线为目标,同时关注新的发展,以提高效率和稳定性。
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引用次数: 0
Regeneration and sustainable chemistry: Current dynamics, interconnections, and perspectives 再生和可持续化学:当前动态,相互联系和观点
IF 9.4 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-12-01 Epub Date: 2025-11-04 DOI: 10.1016/j.cogsc.2025.101055
Vânia G. Zuin Zeidler , Caroindes J. Corrêa Gomes
This paper aims at exploring the role of sustainable chemistry to address regenerative practices, dynamics, and systems as the ones related to agriculture, food production, and processing, including topics such as valorization of agro-industrial waste, biorefinery, biomass, bio-based materials and related flows or processes, renewable resources and energy, considering the links to the United Nations Sustainable Development Goals.
本文旨在探讨可持续化学在解决与农业、粮食生产和加工相关的再生实践、动态和系统方面的作用,包括农业工业废物、生物炼制、生物质、生物基材料及其相关流动或过程、可再生资源和能源等主题,并考虑到与联合国可持续发展目标的联系。
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引用次数: 0
CO2 mitigation via seaweed and microalgae farming for sustainable biofuel production in the blue bioeconomy 通过海藻和微藻养殖,在蓝色生物经济中实现可持续生物燃料生产,减少二氧化碳排放
IF 9.4 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-12-01 Epub Date: 2025-10-23 DOI: 10.1016/j.cogsc.2025.101053
Yaleeni Kanna Dasan , Uganeeswary Suparmaniam , Man Kee Lam , Inn Shi Tan , Sie Yon Lau , Fui Chin Bridgid Lai
Rising carbon dioxide (CO2) levels demand urgent, scalable solutions that decarbonize the energy sector without compromising sustainability. Algae-based carbon capture stands at the frontier of innovation, offering rapid CO2 fixation, low resource input, and versatile biofuel applications. This short review explores recent advances in seaweed and microalgae cultivation for CO2 mitigation, emphasizing their role in the emerging blue bioeconomy. Evaluation of energy use, greenhouse gas emissions, and cost trade-offs from both life cycle and techno-economic perspectives demonstrate the potential of algae as a viable climate solution and a sustainable renewable resource. A harmonized life cycle assessment framework is proposed to guide commercialization of marine biomass for biofuel and successful integration into coastal carbon strategies. The review concludes by identifying key challenges and future directions to scale algae technologies as nature-based carbon sinks for a net-zero future.
不断上升的二氧化碳水平需要紧急的、可扩展的解决方案,在不影响可持续性的情况下使能源部门脱碳。基于藻类的碳捕获站在创新的前沿,提供快速的二氧化碳固定,低资源投入和多种生物燃料应用。这篇简短的综述探讨了海藻和微藻养殖在二氧化碳减排方面的最新进展,强调了它们在新兴的蓝色生物经济中的作用。从生命周期和技术经济角度对能源使用、温室气体排放和成本权衡进行评估,证明了藻类作为一种可行的气候解决方案和可持续可再生资源的潜力。提出了一个统一的生命周期评估框架,以指导用于生物燃料的海洋生物质的商业化,并成功地纳入沿海碳战略。该报告最后确定了将藻类技术作为基于自然的碳汇以实现净零排放未来的关键挑战和未来方向。
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引用次数: 0
Recycling-privileged plastic polymers 具有回收优势的塑料聚合物
IF 9.4 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-12-01 Epub Date: 2025-10-21 DOI: 10.1016/j.cogsc.2025.101049
Jules Armand Wilhelmina Harings , Hendrik Ballerstedt , Lars Mathias Blank
The plastic crisis is in full swing, requiring our collective attention to limit its adverse impact on the environment and human health. Here in, we argue that the high recycling quota required can be more easily achieved when using recycling-privileged plastics, for examplem i.e., plastics that, at the end of their life, are in a technological environment readily depolymerized into their monomers or building blocks of higher, but controlled order (chemistry). Incidentally, recycling rates or recycling quotas are mandated targets, expressed as a percentage, for the amount of waste that must be collected and recycled, often by governments and regulatory bodies. These quotas, such as the EU's overall 65% packaging recycling goal by 2025, aim to promote a circular economy, reduce landfill waste, conserve resources, and decrease pollution. They are calculated as an output-oriented rate, meaning only waste that is successfully reused is counted towards the target. Once degradation pathways are understood, this can be achieved by crossing multiple length scales down to the molecular level to intercept them on time. These recycling-privileged plastics typically contain heteroatomic bonds and are classified as polycondensates, such as polyesters or polyamides. These plastics can consist of novel monomers and/or of modified material, tailored not only for the application but also for recycling. It goes without saying that any future plastic economy relies on alternative carbon sources (biomass, CO2, plastic waste). We state the challenges, present the state-of-the-art of recycling-privileged polymers, and discuss the many possibilities at the end-of-life when polymer physics is used to tailor material properties during and after the utilization phase.
塑料危机愈演愈烈,需要我们共同关注,限制其对环境和人类健康的不利影响。在本文中,我们认为,当使用具有回收特权的塑料时,所需的高回收配额可以更容易地实现,例如,在其使用寿命结束时,在技术环境中容易解聚成单体或更高但受控制的秩序(化学)的构建块的塑料。顺便提一下,回收率或回收配额是强制性目标,通常由政府和监管机构以百分比表示必须收集和回收的废物数量。这些配额,如欧盟到2025年包装回收总量达到65%的目标,旨在促进循环经济,减少垃圾填埋,节约资源,减少污染。它们被计算为面向输出的比率,这意味着只有成功重用的废物才会被计入目标。一旦降解途径被理解,这可以通过跨越多个长度尺度到分子水平来实现,以及时拦截它们。这些具有回收优势的塑料通常含有杂原子键,被归类为缩聚物,如聚酯或聚酰胺。这些塑料可以由新型单体和/或改性材料组成,不仅适合应用,而且适合回收利用。不用说,任何未来的塑料经济都依赖于替代碳源(生物质、二氧化碳、塑料废物)。我们阐述了面临的挑战,介绍了具有回收优势的聚合物的最新技术,并讨论了在使用期间和使用后使用聚合物物理学来定制材料性能的许多可能性。
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引用次数: 0
Special issue on green sorbent materials 绿色吸附材料特刊
IF 9.4 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-10-01 Epub Date: 2025-07-18 DOI: 10.1016/j.cogsc.2025.101042
Mohamed Chaker Necibi, Borhane Mahjoub
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引用次数: 0
Comment to ‘Plasma catalysis for gas conversion—Impact of catalyst on the plasma behavior’ 评《气体转化的等离子体催化——催化剂对等离子体行为的影响》
IF 9.4 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-10-01 Epub Date: 2025-08-11 DOI: 10.1016/j.cogsc.2025.101043
G. Akay , A.R. González-Elipe , A. Gómez-Ramírez
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引用次数: 0
Integrating sustainability in atmospheric chemistry analysis 将可持续性纳入大气化学分析
IF 9.4 2区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2025-10-01 Epub Date: 2025-09-04 DOI: 10.1016/j.cogsc.2025.101048
Regina M.B.O. Duarte, Armando C. Duarte
The concepts that help us to better understand the atmospheric chemistry, including the composition and dynamics of air particles and gaseous species, and their impact on climate and human health, rely on the development of sensitive and selective analytical methods that allow one to measure an ever-increasing range of analytes, whose physicochemical features vary both in time and space. Motivated by the ongoing awareness of the need to adopt eco-friendly practices, this perspective highlights analytical practices with the potential to meet green and sustainable requirements and that have offered an almost unexplored playground for deciphering and mapping the intricacies of atmospheric chemistry. The most promising green metrics currently available to estimate the environmental impact and efficiency of analytical methods are also highlighted. Rather than presenting new quantitative data, this perspective offers a critical and conceptual discussion aimed at advancing the adoption of sustainable analytical solutions in the highly challenging field of atmospheric chemistry analysis.
帮助我们更好地理解大气化学的概念,包括空气颗粒和气体物种的组成和动力学,以及它们对气候和人类健康的影响,依赖于发展敏感和选择性的分析方法,使人们能够测量越来越多的分析物,其物理化学特征在时间和空间上都是不同的。由于人们不断意识到需要采用环保实践,这种观点强调分析实践具有满足绿色和可持续要求的潜力,并且为破译和绘制复杂的大气化学提供了一个几乎未被探索的领域。还强调了目前可用于估计环境影响和分析方法效率的最有前途的绿色指标。而不是提出新的定量数据,这一观点提供了一个关键的和概念性的讨论,旨在推进采用可持续的分析解决方案,在大气化学分析的高度挑战性的领域。
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引用次数: 0
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Current Opinion in Green and Sustainable Chemistry
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