Seminars in Oncology Nursing最新文献

{"title":"Achieving Comprehensive, Patient-Centered Cancer Services: Optimizing the Role of Advanced Practice Nurses at the Core of Precision Health","authors":"Sara Colomer-Lahiguera ,&nbsp;Jenny Gentizon ,&nbsp;Melissa Christofis ,&nbsp;Célia Darnac ,&nbsp;Andrea Serena ,&nbsp;Manuela Eicher","doi":"10.1016/j.soncn.2024.151629","DOIUrl":"10.1016/j.soncn.2024.151629","url":null,"abstract":"<div><h3>Objectives</h3><p>The field of oncology has been revolutionized by precision medicine, driven by advancements in molecular and genomic profiling. High-throughput genomic sequencing and non-invasive diagnostic methods have deepened our understanding of cancer biology, leading to personalized treatment approaches. Precision health expands on precision medicine, emphasizing holistic healthcare, integrating molecular profiling and genomics, physiology, behavioral, and social and environmental factors. Precision health encompasses traditional and emerging data, including electronic health records, patient-generated health data, and artificial intelligence-based health technologies. This article aims to explore the opportunities and challenges faced by advanced practice nurses (APNs) within the precision health paradigm.</p></div><div><h3>Methods</h3><p>We searched for peer-reviewed and professional relevant studies and articles on advanced practice nursing, oncology, precision medicine and precision health, and symptom science.</p></div><div><h3>Results</h3><p>APNs’ roles and competencies align with the core principles of precision health, allowing for personalized interventions based on comprehensive patient characteristics. We identified educational needs and policy gaps as limitations faced by APNs in fully embracing precision health.</p></div><div><h3>Conclusion</h3><p>APNs, including nurse practitioners and clinical nurse specialists, are ideally positioned to advance precision health. Nevertheless, it is imperative to overcome a series of barriers to fully leverage APNs’ potential in this context.</p></div><div><h3>Implications for Nursing Practice</h3><p>APNs can significantly contribute to precision health through their competencies in predictive, preventive, and health promotion strategies, personalized and collaborative care plans, ethical considerations, and interdisciplinary collaboration. However, there is a need to foster education in genetics and genomics, encourage continuous professional development, and enhance understanding of artificial intelligence-related technologies and digital health. Furthermore, APNs’ scope of practice needs to be reflected in policy making and legislation to enable effective contribution of APNs to precision health.</p></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"40 3","pages":"Article 151629"},"PeriodicalIF":2.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0749208124000688/pdfft?md5=3298d21e9bbecce8db1e3a7f477afd7e&pid=1-s2.0-S0749208124000688-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140735010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central Venous Access Device–Associated Skin Complications in Adults with Cancer: A Prospective Observational Study","authors":"Nicole C. Gavin ,&nbsp;Sarah Northfield ,&nbsp;Gabor Mihala ,&nbsp;Margarette Somerville ,&nbsp;Tricia Kleidon ,&nbsp;Nicole Marsh ,&nbsp;Emily Larsen ,&nbsp;Jill Campbell ,&nbsp;Claire M. Rickard ,&nbsp;Amanda J. Ullman","doi":"10.1016/j.soncn.2024.151618","DOIUrl":"10.1016/j.soncn.2024.151618","url":null,"abstract":"<div><h3>Objectives</h3><p>To identify the prevalence and type of central venous access device–associated skin complications for adult cancer patients, describe central venous access device management practices, and identify clinical and demographic characteristics associated with risk of central venous access device–associated skin complications.</p></div><div><h3>Methods</h3><p>A prospective cohort study of 369 patients (626 central venous access devices; 7,682 catheter days) was undertaken between March 2017 and March 2018 across two cancer care in-patient units in a large teaching hospital.</p></div><div><h3>Results</h3><p>Twenty-seven percent (n = 168) of participants had a central venous access device–associated skin complication. In the final multivariable analysis, significant (<em>P</em> &lt; .05) risk factors for skin complications were cutaneous graft versus host disease (2.1 times greater risk) and female sex (1.4 times greater risk), whereas totally implanted vascular access device reduced risk for skin complications by two-thirds (incidence risk ratio 0.37).</p></div><div><h3>Conclusion</h3><p>Central venous access device–associated skin complications are a significant, potentially avoidable injury, requiring cancer nurses to be aware of high-risk groups and use evidence-based preventative and treatment strategies.</p></div><div><h3>Implications for Practice</h3><p>This study has confirmed how common these potentially preventable injuries are. Therefore, the prevalence of these complications could be reduced by focusing on improvements in skin assessment, reductions in central venous access device dressing variation and improving clinician knowledge of this injury.</p></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"40 3","pages":"Article 151618"},"PeriodicalIF":2.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0749208124000573/pdfft?md5=1dd174d37cac2dbace85b372b69cc946&pid=1-s2.0-S0749208124000573-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140783585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Practice Pediatric Oncology Nursing as Imagined or In Place in Four Lower- and Upper-Middle-Income Countries","authors":"Remziye Semerci ,&nbsp;Vera Larfi Samba ,&nbsp;Dorian René Navarro Diaz ,&nbsp;Rehana Punjwani ,&nbsp;Julia Challinor","doi":"10.1016/j.soncn.2024.151631","DOIUrl":"10.1016/j.soncn.2024.151631","url":null,"abstract":"<div><h3>Objectives</h3><p>The implementation of pediatric oncology advanced practice nurse (s) roles in low- and middle-income countries (LMICs) presents opportunities and challenges. The authors explore the implications of pediatric oncology advanced practice nursing roles in Pakistan, Cameroon, Turkey, and Mexico. Potential benefits and drawbacks of advanced practice nursing roles, impacts on nursing care, and strategies for advanced practice nursing role development in LMIC settings are considered.</p></div><div><h3>Methods</h3><p>Information from scholarly articles, policy documents, and four LMIC pediatric oncology nurse expert perspectives on existing and imagined advanced practice nursing roles in pediatric oncology in LMIC were synthesized.</p></div><div><h3>Results</h3><p>Current literature and policies point to efforts across LMICs to establish a wide variety of advanced nursing practices, not necessarily aligned with internationally accepted advanced practice nursing standards of practice or education. The LMIC nurses describe a wide range of national general nurse education and government advanced practice nurse recognition/licensing. Challenges to achieving or strengthening advanced practice nursing roles include, for example, healthcare professional resistance, government unwillingness to recognize/license advanced practice nurses, and lack of advanced practice nursing faculty. To promote a pediatric oncology advanced practice nursing role in LMICs requires navigating the national nursing scope of practice and nursing culture.</p></div><div><h3>Conclusion</h3><p>The strategic introduction of pediatric oncology advanced practice nursing roles in LMICs has the potential to significantly enhance patient care by, for example, addressing healthcare workforce shortages and facilitating timely care delivery. However, challenges related to role complexity, resistance from traditional healthcare structures, and role overlap must be considered. Tailoring these roles to local contexts and fostering stakeholder collaboration are essential for successful implementation.</p></div><div><h3>Implications for Nursing Practice</h3><p>The adoption of advanced practice nursing roles can lead to improved quality of care for pediatric oncology patients and their families in LMICs, where cancer care is challenging. The positive impact of pediatric oncology advanced practice nurses on patient outcomes and healthcare delivery cannot be discounted but must align with local nursing and healthcare culture and expectations.</p></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"40 3","pages":"Article 151631"},"PeriodicalIF":2.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140913107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Building Career Pathways for Cancer Nurses: Ensuring Cancer Nursing's Future","authors":"Gemma McErlean ,&nbsp;Catherine Paterson ,&nbsp;Carla Thamm","doi":"10.1016/j.soncn.2024.151633","DOIUrl":"10.1016/j.soncn.2024.151633","url":null,"abstract":"<div><h3>Objectives</h3><p>It is well established that cancer nurses and advanced practice nurses (APN) are critical to the delivery of high-quality, accessible, safe, and affordable cancer care globally. Specialized cancer nurses and APNs with a strong foundation in the pillars of nursing practice (clinical, leadership, education, and research) are essential to optimize patient outcomes, create increased cost-efficiencies through innovative models of care delivery, and can further leverage interprofessional collaboration in cancer care. To address the existing shortcomings in cancer control, Australian cancer nurses, including APNs, and cancer nurses and APNs globally, need an evidence-informed consensus drive framework to harmonize clinical, educational and career pathways leading to specialization, advanced practice, promotion, and equitable and accessible education.</p></div><div><h3>Methods</h3><p>Critical perspective.</p></div><div><h3>Results</h3><p>Scoping work has begun to build on the 2009 seminal Australian EdCaN framework, with ambitions to develop a contemporary practice and career framework for all cancer nurses which details clear pathways to specialized and APN roles inclusive of navigating to and through direct clinical care, research, academia, education, and management or executive leadership.</p></div><div><h3>Conclusions</h3><p>A revised framework that is cognizant of the changing landscape of contemporary cancer care, and the growing diversity of nursing roles is needed to address the imminent nursing workforce crisis.</p></div><div><h3>Implications for Nursing Practice</h3><p>The revised framework may support the implementation of the newly released Australian Cancer Plan and provide a career pathway model that may be adopted internationally, including in low- and middle-income countries.</p></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"40 3","pages":"Article 151633"},"PeriodicalIF":2.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S074920812400072X/pdfft?md5=5cf7d5b70f78d8ac20194f1101cc05f4&pid=1-s2.0-S074920812400072X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140913115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Attitudes Toward Death, Rumination, and Psychological Resilience of Oncology Nurses","authors":"Yeter Sinem Üzar-Özçetin ,&nbsp;Simay Ezgi Budak","doi":"10.1016/j.soncn.2024.151645","DOIUrl":"10.1016/j.soncn.2024.151645","url":null,"abstract":"<div><h3>Objectives</h3><p>The study aimed to examine the relationship between attitudes toward death, rumination, and psychological resilience of oncology nurses.</p></div><div><h3>Methods</h3><p>The study design was cross-sectional. Data were collected from 118 oncology nurses using the Demographic Data Form, Work-Related Rumination Scale, Connor-Davidson Resilience Scale Short Form, and Death Attitude Profile-Revised Scale. For data analysis, correlation and regression analyses were performed.</p></div><div><h3>Results</h3><p>The study findings showed that oncology nurses` work related rumination score was moderate, while psychological resilience score was severely high. More than two-thirds of the work-related ruminations of oncology nurses were explained by psychological resilience and attitudes toward death. Even though there is a negative correlation between negative attitudes toward death and psychological resilience, the acceptance of death scores showed positive relations with psychological resilience.</p></div><div><h3>Conclusion</h3><p>Nurses with positive attitudes toward death can also develop psychological resilience and experience fewer work-related ruminations. This result reveals the necessity of determining oncology nurses' attitudes toward death in order to protect their psychological resilience and reduce work-related ruminations. It is also evident that the results are valuable in presenting how nurses' work-related ruminations relate to psychological resilience and attitudes toward death.</p></div><div><h3>Implications for Nursing Practice</h3><p>Nurses are the main care providers in oncology settings, and they are witnessing the suffering process of their patients and experiencing the loss of their patients. These challenges bring work-related ruminations that lower the psychological resilience of nurses and affect attitudes toward death. Therefore, nurses can build an awareness of their ruminations and develop coping skills with intrusive ruminations.</p></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"40 3","pages":"Article 151645"},"PeriodicalIF":2.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140772168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Practice Nursing Titles and Roles in Cancer Care: A Scoping Review","authors":"Maura Dowling ,&nbsp;Eva Pape ,&nbsp;Franziska Geese ,&nbsp;Ann Van Hecke ,&nbsp;Denise Bryant-Lukosius ,&nbsp;M. Consuelo Cerón ,&nbsp;Paz Fernández-Ortega ,&nbsp;Francisca Marquez-Doren ,&nbsp;Ashleigh Ward ,&nbsp;Cherith Semple ,&nbsp;Tracy King ,&nbsp;Manela Glarcher ,&nbsp;Amanda Drury","doi":"10.1016/j.soncn.2024.151627","DOIUrl":"10.1016/j.soncn.2024.151627","url":null,"abstract":"<div><h3>Objectives</h3><p>Advanced practice nursing roles in cancer care are diverse and exist across the cancer care continuum. However, the titles used and the scope of practice differ across countries. This diversity is likely to be misleading to patients and influence nurses’ contribution to health care. An understanding of the current state of advanced practice nursing roles in cancer care internationally is needed to inform opportunities for future role development and enhance cancer nursing career pathways.</p></div><div><h3>Methods</h3><p>This scoping review included a systematic search of four databases: MEDLINE, CINAHL, PsycINFO, and Academic Search Complete. Independent screening for papers meeting the review's inclusion criteria was undertaken using online screening software. Data extraction, coding, and mapping were undertaken in NVivo 12.</p></div><div><h3>Results</h3><p>Of the 13,409 records identified, 108 met the review's inclusion criteria. A variety of roles in cancer care settings were described. The United States and the United Kingdom had the most titles for advanced practice nursing roles. Tumor-specific roles were described and integrated into different phases of the cancer care continuum. Trends in continuing professional development for advanced practice nurses in cancer care included the rise in Fellowship programs in the United States and practice-based education in the United Kingdom.</p></div><div><h3>Conclusions</h3><p>The differences in advanced practice nursing roles in cancer care allow regional and institutional variation to meet the needs of patient populations and health care system demands. However, a lack of clarity surrounding titles and roles results in confusion and underutilization of these nurses’ highly specialized skill sets.</p></div><div><h3>Implications for Nursing Practice</h3><p>Incongruence in titles and scope of practice internationally will ultimately result in a merging of roles. There is a need for international agreement on education requirements for advanced practice nursing roles to promote career pathways.</p></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"40 3","pages":"Article 151627"},"PeriodicalIF":2.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0749208124000664/pdfft?md5=64a00ca56cb9da9f641a4ad2d9589282&pid=1-s2.0-S0749208124000664-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-Reported Outcome and Experience Measures in Advanced Nursing Practice: What Are Key Considerations for Implementation and Optimized Use?","authors":"Amanda Drury ,&nbsp;Vanessa Boland ,&nbsp;Maura Dowling","doi":"10.1016/j.soncn.2024.151632","DOIUrl":"10.1016/j.soncn.2024.151632","url":null,"abstract":"<div><h3>Objective</h3><p>To discuss the opportunities and challenges of implementing patient-reported outcome measures (PROMs) and patient-reported experience measures (PREMs) within advanced practice nursing services in cancer care.</p></div><div><h3>Methods</h3><p>This discussion paper has been informed by an environmental scan of evidence from systematic reviews and primary studies evaluating the use and implementation of PROMs and PREMs. Literature from the contexts of cancer and chronic disease, including nursing and multidisciplinary supportive care literature, has been included.</p></div><div><h3>Results</h3><p>Advanced practice nurses are well-positioned to evaluate and respond to PROMs and PREMs data; several studies have highlighted improved patient outcomes concerning quality of life, symptom distress, and functional status within nurse-led services. Nevertheless, the implementation of PROMs and PREMs in cancer care and nurse-led services is variable. Previous studies have highlighted implementation challenges, which can hinder comparability and generalizability of PROMs and PREMs instruments. Advanced practice nurses should consider these challenges, including ways to use standardized PROM instruments. Electronic PROMs, while efficient, may exclude individuals at risk of inequity. Complex, lengthy, and frequent administration of PROMs may also overburden people living with or after cancer, with people affected by cancer expressing preference for flexible use in some studies. Therefore, the involvement of people affected by cancer in planning for PROMs/PREMs implementation may overcome this challenge. Finally, organizational considerations in implementation should address financial investments, including initial costs for technology and training and consideration of the operationalization of PROMs within existing infrastructure for the seamless utilization of PROMs data.</p></div><div><h3>Conclusion</h3><p>Despite the potential of advanced practice nursing services to enhance patient-reported outcomes and experiences, variability in the implementation of PROMs and PREMs poses challenges. Use of validated measures, electronic or paper-based instruments, and the preferences of people affected by cancer for the use of PROMs and PREMs must be carefully considered in consultation with end users for successful implementation.</p></div><div><h3>Implications for Practice</h3><p>In planning for the implementation of PROMs and PREMs within nurse-led services, implementation risks may be mitigated through establishing clear guidelines for their use, investment in the development of the required infrastructure, user education, and rigorous implementation processes, including patient involvement in PROMs/PREMs selection.</p></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"40 3","pages":"Article 151632"},"PeriodicalIF":2.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0749208124000718/pdfft?md5=949fd7b9ef8683bb874ea2ff86ee31f9&pid=1-s2.0-S0749208124000718-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140764561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘The Effect of Psychosocial Support Videos Provided by the Community on Disease Attitudes and Symptoms of Pediatric Oncology Patients: Randomized Controlled Study’ [Seminars in Oncology Nursing 40 (2024) 151570]","authors":"Remziye Semerci ,&nbsp;Eyşan Hanzade Savaş ,&nbsp;Ezgi Gizem Gürbüz ,&nbsp;Nazlı Başegen ,&nbsp;Münevver Erkul ,&nbsp;Kübra Alki ,&nbsp;Ezgi Paslı Uysalol","doi":"10.1016/j.soncn.2024.151653","DOIUrl":"10.1016/j.soncn.2024.151653","url":null,"abstract":"","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"40 3","pages":"Article 151653"},"PeriodicalIF":2.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0749208124001025/pdfft?md5=f125f4be00e0a5c538522f795ba82dfd&pid=1-s2.0-S0749208124001025-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Future-Oriented Perspective on Advanced Practice Nursing Roles in Cancer Care: Pushing the Boundaries to Promote Innovation and Achieve Equitable, Patient-Centered Care","authors":"Denise Bryant-Lukosius ,&nbsp;Eva Pape ,&nbsp;Maura Dowling","doi":"10.1016/j.soncn.2024.151635","DOIUrl":"10.1016/j.soncn.2024.151635","url":null,"abstract":"","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"40 3","pages":"Article 151635"},"PeriodicalIF":2.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140769963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nursing Considerations for Cytokine Release Syndrome in Relapsed/Refractory Multiple Myeloma: Experience with Teclistamab from the MajesTEC-1 Study","authors":"Donna Catamero ,&nbsp;Patricia Blázquez Benito ,&nbsp;Samantha Shenoy ,&nbsp;Margaret Doyle ,&nbsp;Jessica Fowler ,&nbsp;Rachel Kobos ,&nbsp;Arnob Banerjee ,&nbsp;Sandy Kruyswijk","doi":"10.1016/j.soncn.2024.151621","DOIUrl":"10.1016/j.soncn.2024.151621","url":null,"abstract":"<div><h3>Objectives</h3><p>Cytokine release syndrome (CRS) is a systemic inflammatory response that is commonly observed as a class effect of T-cell–redirecting therapies. This article provides important practical guidance for nurses relating to the diagnosis, monitoring, and management of CRS in patients receiving teclistamab, based on experience from the MajesTEC-1 clinical trial and real-life nursing practice.</p></div><div><h3>Methods</h3><p>MajesTEC-1 is a phase 1/2 study of teclistamab in heavily pretreated patients with relapsed/refractory multiple myeloma. To mitigate the risk of high-grade CRS, patients were carefully monitored for early signs and symptoms of CRS (including fever, which must have fully resolved before teclistamab administration).</p></div><div><h3>Results</h3><p>A survey of nurses from several of the study sites provided additional real-life insights into nursing best practices for managing CRS from four academic institutions in three countries.</p></div><div><h3>Conclusions</h3><p>In MajesTEC-1, 72% of patients treated with teclistamab experienced CRS, the majority of which was low grade. All cases resolved and none led to treatment discontinuation. Real-life supportive measures for CRS are generally aligned with those outlined in the study.</p></div><div><h3>Implications for Nursing Practice</h3><p>Because nurses are on the frontline of patient care, they play a crucial role in promptly recognizing the signs and symptoms of CRS and responding with timely and appropriate supportive treatment. This review provides important practical guidance for nurses on diagnosis, monitoring, and management of CRS in patients receiving teclistamab, based on experience from the MajesTEC-1 trial and real-life nursing practice.</p></div>","PeriodicalId":54253,"journal":{"name":"Seminars in Oncology Nursing","volume":"40 3","pages":"Article 151621"},"PeriodicalIF":2.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0749208124000603/pdfft?md5=3b8e7a4c37b6d9a8f4c28eda0e94269f&pid=1-s2.0-S0749208124000603-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140792433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}