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The contribution of professor Paul Karrer (1889–1971) to dextrins 保罗·卡雷尔教授(1889-1971)对糊精的贡献
IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-02-18 DOI: 10.1007/s10847-021-01049-7
Grégorio Crini

Paul Karrer (1889–1971), a Swiss organic chemist best known for his research on vitamins, has published more than 1000 articles. In 1919, Karrer became professor of chemistry at the University of Zurich and in the same year he was appointed director of the Chemical Institute in Zurich, where he remained until his retirement in 1959. Karrer’s most famous work was on vitamins, and probably his most important contribution was his demonstration in 1931 that vitamin A was structurally related to carotenoid. Karrer also published important works on natural products, carotenoids and other plant pigments, coenzymes, alkaloids, amino acids, sugars, carbohydrates, polysaccharides, and organometallic compounds. Professor Karrer was awarded the Nobel Prize in chemistry in 1937 for his research into the constitution of carotenoids, flavins and vitamins A and B2, a prize shared with the British chemist Sir Walter Norman Haworth. However, few researchers working in the field of cyclodextrins know that Karrer was also one of the first to take an interest in these molecules. Between 1920 and 1925, he published several studies on the nomenclature, structure and chemistry of dextrin-α and dextrin-β. This historical review, on the occasion of the fiftieth anniversary of his death, aims, on the one hand, to retrace his immense scientific career highlighting selected works on vitamins and alkaloids and, on the other hand, to commemorate his contribution to (cyclo)dextrin chemistry.

保罗·卡雷尔(1889-1971),瑞士有机化学家,以其对维生素的研究而闻名,发表了1000多篇文章。1919年,卡雷尔成为苏黎世大学的化学教授,同年,他被任命为苏黎世化学研究所所长,直到1959年退休。卡雷尔最著名的工作是关于维生素的,他最重要的贡献可能是他在1931年证明了维生素A在结构上与类胡萝卜素有关。卡雷尔还发表了关于天然产物、类胡萝卜素和其他植物色素、辅酶、生物碱、氨基酸、糖、碳水化合物、多糖和有机金属化合物的重要著作。1937年,卡雷尔教授因研究类胡萝卜素、黄素、维生素A和维生素B2的构成而获得诺贝尔化学奖,并与英国化学家沃尔特·诺曼·霍沃斯爵士分享了这一奖项。然而,在环糊精领域工作的研究人员很少知道Karrer也是第一个对这些分子感兴趣的人之一。1920年至1925年间,他发表了几篇关于糊精-α和糊精-β的命名、结构和化学的研究。在他逝世五十周年之际进行这一历史回顾,一方面旨在回顾他辉煌的科学生涯,重点介绍有关维生素和生物碱的若干著作,另一方面纪念他对(环)糊精化学的贡献。
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引用次数: 0
Direct short-wave photolysis of chlorpyrifos-methyl and chlorpyrifos-methyl oxon in the presence of cyclodextrins 环糊精存在下毒死蜱-甲基和毒死蜱-甲基氧的直接短波光解
IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-02-12 DOI: 10.1007/s10847-021-01046-w
Virginia L. Lobatto, Gustavo A. Argüello, Elba I. Buján
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引用次数: 0
Novel optically active 2D materials based on λ-zirconium phosphate and chiral monocarboxylic acids: Synthesis and characterization 基于λ-磷酸锆和手性一元羧酸的新型光学活性二维材料:合成与表征
IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-02-05 DOI: 10.1007/s10847-021-01043-z
Hussein Alhendawi, Ernesto Brunet, Elena Rodríguez Payán, Huda Alkahlout

Five novel chiral 2D materials with general formula λ-ZrPO4(OH)1-x(RCOO)x(dmso) have been prepared by covalent anchoring of five different chiral carboxylic acids to the sheets of λ-zirconium phosphate (λ-ZrP), namely (S)-(+)-Mandelic acid (MAN), (R)-(?)-α-Methoxyphenylacetic acid (MPA), (S)-(+)-Ibuprofen (IBU), (S)-(+)-6-Methoxy-α-methyl-2-naphthaleneacetic acid (MMN) and (?)-Menthyloxyacetic acid (MEN). The synthesized materials were characterized by X-ray diffractometry, FT-IR spectrophotometry, elemental and thermogravimetric analyses and polarimetry. The X-ray diffraction patterns revealed that the interlayer separations increase from 1.02?nm (pure λ-ZrP) to 1.31–2.31?nm as a result of the incorporation of the mentioned acids within the interlayer gallery. The polarimetry measurements showed that the synthesized materials have appreciable optical activities suggesting they could have protentional applications in the field of chiral separation techniques.

以五种不同的手性羧酸为共价锚定剂,在λ-磷酸锆(λ-ZrP)片上制备了五种通式为λ-ZrPO4(OH)1-x(RCOO)x(dmso)的新型二维手性材料,即(S)-(+)- mandelic acid (MAN)、(R)-(?)-α-甲氧基苯基乙酸(MPA)、(S)-(+)- ibuprofen (IBU)、(S)-(+)-6-甲氧基-α-甲基-2-萘乙酸(MMN)和(?)- menthyloxyacetic acid (MEN)。采用x射线衍射、红外光谱、元素分析、热重分析和偏振法对合成材料进行了表征。x射线衍射图显示,层间分离从1.02?nm(纯λ-ZrP)至1.31-2.31 ?Nm是上述酸在层间廊内结合的结果。旋光测量结果表明,合成材料具有明显的旋光活性,在手性分离技术领域具有潜在的应用前景。
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引用次数: 1
Inclusion complexation of 4′,6-diamidino-2-phenylindole (DAPI) with cucurbit[7]uril and cyclodextrins (native β-, 2,6-di-O-methylated β-, and γ-cyclodextrin): characteristic inclusion behaviour and fluorescence enhancement 4′,6-二氨基-2-苯基吲哚(DAPI)与葫芦[7]脲和环糊精(天然β-、2,6-二o-甲基化β-和γ-环糊精)的包合:特征包合行为和荧光增强
IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-01-14 DOI: 10.1007/s10847-020-01042-6
Yoshimi Sueishi, Seiya Hagiwara, Naoya Inazumi, Tadashi Hanaya

Herein, we investigated the inclusion complexation of a fluorescent probe [4′,6-diamidino-2-phenylindole (DAPI)]?using various cyclodextrins (CDs) and cucurbit[7]uril (CB7). Using the?continuous variation method, DAPI was found to form a 1:1 inclusion complex with CDs and CB7. 1H-NMR and 2D ROESY (1H-1H rotating frame nuclear Overhauser effect) spectroscopy indicated that the inclusion of DAPI by the CDs and CB7 occurs via the encapsulation of the phenyl group and indole moiety of DAPI. The stability of the CB7?inclusion complex was higher than?that of the CDs: the stability was attributed to the extra interaction formed between the dicationic dye (DAPI) and polar carbonyl groups at the portals of CB7. Furthermore, we determined the fluorescence quantum yield (Φ) of the inclusion complexes. The Φ values of DAPI were significantly enhanced upon its inclusion by CB7 and increased as the empirical solvent polarity parameter (ET(30)) decreased. Based on these results, we concluded that the polarity of the microenvironment and protonation ability of the excited state of DAPI play important roles in emission efficiency.

本文中,我们研究了荧光探针[4 ',6-二氨基-2-苯基吲哚(DAPI)]?使用各种环糊精(CDs)和葫芦[7]脲(CB7)。使用?连续变分法,发现DAPI与CDs和CB7形成1:1的包合物。1H-NMR和2D ROESY (1H-1H旋转框架核Overhauser效应)谱分析表明,CDs和CB7包合DAPI是通过包封DAPI的苯基和吲哚部分实现的。CB7的稳定性?包合络合物高于?CDs的稳定性是由于在CB7的入口处,指示染料(DAPI)和极性羰基之间形成了额外的相互作用。此外,我们测定了包合物的荧光量子产率(Φ)。DAPI的Φ值在CB7包合后显著增强,并随着经验溶剂极性参数ET(30)的减小而增大。基于这些结果,我们得出微环境的极性和DAPI激发态的质子化能力对发射效率有重要影响。
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引用次数: 3
Rapid temperature-assisted synthesis of nanoporous γ-cyclodextrin-based metal–organic framework for selective CO2 adsorption 纳米多孔γ-环糊精基金属-有机骨架的快速温度辅助合成及其选择性CO2吸附
IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-01-14 DOI: 10.1007/s10847-020-01039-1
Asma Hamedi, Anastasia Anceschi, Francesco Trotta, Mahdi Hasanzadeh, Fabrizio Caldera

We present a rapid and surfactant-free temperature-assisted synthesis route to prepare γ-cyclodextrin-based metal–organic framework (γ-CD-MOF). The cubic crystals of the CD-MOF with an average edge length of 10–15 μm, specific surface area of 775?m2 g?1 and total pore volume of 0.229?cm3 g?1 were synthesized in much shorter time than conventional CD-MOFs. To show the efficiency of the synthesized CD-MOF as adsorbent of gas, the uptake of CO2 at different temperature and pressure was investigated. It is shown that the CO2 uptake increases with increasing pressure and decreasing temperature. Further microgravimetric investigation on gas adsorption at low pressure demonstrated superior gas uptake (ca. 147?mg g?1) than previous reports. At the maximum equilibrium pressure, the uptake amounts of CO2 were found to be 326 and 268?mg g?1 at 303 and 323?K, respectively. The synthesized CD-MOF has great potential to be used in gas storage and separation applications.

提出了一种快速、无表面活性剂的温度辅助合成γ-环糊精基金属有机骨架(γ-CD-MOF)的方法。CD-MOF的立方晶体平均边长为10 ~ 15 μm,比表面积为775?m2 g ?总孔隙体积为0.229?立方厘米g ?与传统的cd - mof相比,1的合成时间大大缩短。为了证明合成的CD-MOF作为气体吸附剂的效率,研究了不同温度和压力下CD-MOF对CO2的吸收率。结果表明,CO2吸收量随压力的增加和温度的降低而增加。进一步的气体吸附微重力研究表明,在低压下气体吸收率更高(约147?Mg ?1)。在最大平衡压力下,CO2的吸收量分别为326和268?mg g ?303和323的1个?分别K。合成的CD-MOF在气体储存和分离方面具有很大的应用潜力。
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引用次数: 19
p-Sulfonatocalixarene versus p-thiasulfonatocalixarene: encapsulation of tenofovir disoproxil fumarate and implications to ESI-MS, HPLC, NMR, DFT and anti-MRSA activities 对磺酰基杯芳烃与对巯基杯芳烃:富马酸替诺福韦二氧吡酯的包封及其对ESI-MS、HPLC、NMR、DFT和抗mrsa活性的影响
IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-01-14 DOI: 10.1007/s10847-020-01022-w
Asmita B. Jarange, Sanhita V. Patil, Dipalee D. Malkhede, Shreya M. Deodhar, Vinod S. Nandre, Sulakshana V. Athare, Kisan M. Kodam, Shridhar P. Gejji

The inclusion complexes of tenofovir disoproxil fumarate (TDF) with p-sulfonato-calix[4]arene (SCX4) and p-sulfanatothiacalix[4]arene (TSCX4) macrocycles are characterized through an array of experiments including 1H NMR, NOESY, HPLC, HRMS, FT-IR and PXRD in conjunction with the density functional theory. An encapsulation of TDF within SCX4 and TSCX4 macrocycles conduce 1:1 complexes those prevail over 1:2 or 1:3 Stoichiometries which exhibis distinct structural features. A loss of crystallinity accompanying the complexation ascertains the inclusion of the guest within the macrocycle. A comparison of the measured 13C NMR spectra of the complexes with individual hosts ascertains the cone conformation of SCX4 in such complexes as in its free state. It has been demonstrated that the TDF guest penetrates deeply within the cavity of SCX4 facilitating the hydrogen bonding interactions between adenine protons and the hydroxyl as well as methylene protons of the macrocycle. The measured 1H NMR spectra thus reveal large upfield signals (δ 8.35, 8.48?ppm) for adenine protons of the SCX4 complex. On the other hand, the partial encapsulation of TDF in TSCX4 reflects in the deshielding of hydroxyl protons in the measured 1H NMR spectra. The characteristic C=N and SO stretching vibrations in the infrared spectra engender’frequency shifts’ in the opposite directions compared to the individual host or guest. A simple reverse phase high performance liquid chromatography method is presented. The adenine encapsulation further has been qualitatively correlated with MRSA activities.

结合密度泛函理论,通过1H NMR、noesi、HPLC、HRMS、FT-IR和PXRD等一系列实验表征了富马酸替诺福韦二氧吡酯(TDF)与对磺酰基杯[4]芳烃(SCX4)和对磺酰基杯[4]芳烃(TSCX4)大环的包合物。将TDF包封在SCX4和TSCX4大环内可形成1:1的配合物,这些配合物优于1:2或1:3的化学计量学,具有明显的结构特征。结晶度的损失伴随着络合确定了客体在大环内的包含。通过与单个宿主的13C核磁共振谱的比较,确定了SCX4在这些配合物中如在其自由状态下的锥形构象。研究表明,TDF客体深入SCX4的腔内,促进了腺嘌呤质子与大环的羟基和亚甲基质子之间的氢键相互作用。因此,测量的1H NMR谱揭示了SCX4配合物的腺嘌呤质子的大上场信号(δ 8.35, 8.48?ppm)。另一方面,TDF在TSCX4中的部分包封反映在1H NMR谱中羟基质子的去屏蔽。红外光谱中的特征C=N和SO伸展振动产生与单个主客体相反方向的“频移”。提出了一种简单的反相高效液相色谱法。腺嘌呤包封进一步与MRSA活性定性相关。
{"title":"p-Sulfonatocalixarene versus p-thiasulfonatocalixarene: encapsulation of tenofovir disoproxil fumarate and implications to ESI-MS, HPLC, NMR, DFT and anti-MRSA activities","authors":"Asmita B. Jarange,&nbsp;Sanhita V. Patil,&nbsp;Dipalee D. Malkhede,&nbsp;Shreya M. Deodhar,&nbsp;Vinod S. Nandre,&nbsp;Sulakshana V. Athare,&nbsp;Kisan M. Kodam,&nbsp;Shridhar P. Gejji","doi":"10.1007/s10847-020-01022-w","DOIUrl":"https://doi.org/10.1007/s10847-020-01022-w","url":null,"abstract":"<p>The inclusion complexes of tenofovir disoproxil fumarate (TDF) with <i>p</i>-sulfonato-calix[4]arene (SCX4) and <i>p</i>-sulfanatothiacalix[4]arene (TSCX4) macrocycles are characterized through an array of experiments including <sup>1</sup>H NMR, NOESY, HPLC, HRMS, FT-IR and PXRD in conjunction with the density functional theory. An encapsulation of TDF within SCX4 and TSCX4 macrocycles conduce 1:1 complexes those prevail over 1:2 or 1:3 Stoichiometries which exhibis distinct structural features. A loss of crystallinity accompanying the complexation ascertains the inclusion of the guest within the macrocycle. A comparison of the measured <sup>13</sup>C NMR spectra of the complexes with individual hosts ascertains the cone conformation of SCX4 in such complexes as in its free state. It has been demonstrated that the TDF guest penetrates deeply within the cavity of SCX4 facilitating the hydrogen bonding interactions between adenine protons and the hydroxyl as well as methylene protons of the macrocycle. The measured <sup>1</sup>H NMR spectra thus reveal large upfield signals (δ 8.35, 8.48?ppm) for adenine protons of the SCX4 complex. On the other hand, the partial encapsulation of TDF in TSCX4 reflects in the deshielding of hydroxyl protons in the measured <sup>1</sup>H NMR spectra. The characteristic C=N and SO stretching vibrations in the infrared spectra engender’frequency shifts’ in the opposite directions compared to the individual host or guest. A simple reverse phase high performance liquid chromatography method is presented. The adenine encapsulation further has been qualitatively correlated with MRSA activities.</p>","PeriodicalId":54324,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"99 1-2","pages":"43 - 59"},"PeriodicalIF":2.3,"publicationDate":"2021-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10847-020-01022-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4573540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Alternative purification protocols of mixed pyridines in the presence of trans-N,N′-bis(9-phenyl-9-xanthenyl)cyclohexane-1,4-diamine 混合吡啶在反式N,N ' -双(9-苯基-9-黄杂基)环己烷-1,4-二胺存在下的替代纯化方案
IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-01-01 DOI: 10.1007/s10847-020-01037-3
Benita Barton, Mino R. Caira, Daniel V. Jooste, Eric C. Hosten

In this communication, we reveal that the host compound trans-N,N′-bis(9-phenyl-9-xanthenyl)cyclohexane-1,4-diamine (1,4-DAX) possesses the ability to purify 2-methylpyridine (2MP)/pyridine (PYR) and 3-methylpyridine (3MP)/PYR binary mixtures by enclathrating PYR almost exclusively, even when such mixtures contained as little as approximately 30% PYR. For example, when these solutions were prepared with equimolar quantities of the two guests, complexes contained as much as 92.4 and 96.4% PYR, respectively. Furthermore, 1,4-DAX was capable of forming a mixed complex with as high as 87.8% PYR from an equimolar ternary mixture containing 2MP, 3MP and PYR through host?guest complexation. This work complements that of trans-N,N′-bis(9-phenyl-9-xanthenyl)cyclohexane-1,2-diamine (1,2-DAX) and trans-N,N′-bis(9-phenyl-9-thioxanthenyl)cyclohexane-1,2-diamine (1,2-DAT), disclosed in a previous submission, where 4-methylpyridine (4MP) and 2MP, correspondingly, were the preferred guest solvents. Interestingly, trans-N,N′-bis(9-phenyl-9-thioxanthenyl)cyclohexane-1,4-diamine (1,4-DAT) showed no inclusion tendencies under such conditions. Successfully-formed inclusion complexes were subjected to crystal X-ray diffraction analyses in order to understand the preference of 1,4-DAX for 4MP and PYR. Thermal analyses of these complexes were, however, less informative.

在这篇通讯中,我们揭示了宿主化合物反式N,N ' -双(9-苯基-9-黄杂基)环己烷-1,4-二胺(1,4- dax)具有通过包膜PYR几乎完全纯化2-甲基吡啶(2MP)/吡啶(PYR)和3-甲基吡啶(3MP)/PYR二元混合物的能力,即使这些混合物中PYR含量只有大约30%。例如,当用等摩尔量的两种客体制备这些溶液时,配合物的PYR含量分别高达92.4和96.4%。此外,1,4- dax能够将含有2MP, 3MP和PYR的等摩尔三元混合物通过宿主形成PYR高达87.8%的混合配合物。客人络合。该研究补充了先前提交的反式N,N ' -双(9-苯基-9-黄杂基)环己烷-1,2-二胺(1,2- dax)和反式N,N ' -双(9-苯基-9-硫杂基)环己烷-1,2-二胺(1,2- dat),其中4-甲基吡啶(4MP)和2MP分别是首选的客体溶剂。有趣的是,在这种条件下,反式N,N ' -双(9-苯基-9-硫代杂蒽基)环己烷-1,4-二胺(1,4- dat)没有包合倾向。成功形成的包合物进行了晶体x射线衍射分析,以了解1,4- dax对4MP和PYR的偏好。然而,这些配合物的热分析信息较少。
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引用次数: 4
Design and optimization of cyclodextrin-based nanosponges of antimalarials using central composite design for dry suspension 干悬浮中心复合设计抗疟药环糊精纳米海绵的设计与优化
IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-01-01 DOI: 10.1007/s10847-020-01038-2
Sandip Pawar, Pravin Shende
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引用次数: 6
Liquid-liquid extraction and facilitated membrane transport of Pb2+ using a lipophilic acridono-crown ether as carrier 以亲脂性吖啶酮冠醚为载体,液液萃取Pb2+并促进其膜转运
IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2020-12-21 DOI: 10.1007/s10847-020-01036-4
Ádám Golcs, László Bezúr, Péter Huszthy, Tünde Tóth

Studies on liquid-liquid extraction and bulk liquid membrane (BLM) technique-based metal ion separation by a previously published Pb2+-selective acridono-18-crown-6 ether selector molecule were performed. The effects of the stirring speed, the quality of apolar organic membrane, the counterions of Pb2+, the pH of the aqueous phase, the concentration of the source phase, the concentration of the carrier in the BLM and the temperature on the Pb2+-separation were investigated. Moreover, the effects of the competitive inhibition due to the presence of Ag+, Ca2+, Co2+, Cu2+, K+, Mg2+, Na+ and Zn2+ as competing ions in a multicomponent aqueous source phase of different ion-concentrations were also studied. After a proper dilution of the multicomponent aqueous source phase, excellent Pb2+-selectivity was achieved without a significant reduction in the efficiency compared to the liquid membrane transport of single-component systems. Based on the BLM-cell studies the applied selector molecule proved to be suitable for the development of liquid membrane-based Pb2+-selective separation methods, which can be greatly aided by the analysis of the effects on the separation and by the optimization of the parameters of the process discussed here.

利用已发表的Pb2+选择性吖啶醇-18-冠-6醚选择分子,研究了基于液液萃取和体液膜(BLM)技术的金属离子分离。考察了搅拌速度、极性有机膜质量、Pb2+反离子、水相pH、源相浓度、BLM中载体浓度、温度等因素对Pb2+分离的影响。此外,还研究了Ag+、Ca2+、Co2+、Cu2+、K+、Mg2+、Na+和Zn2+作为竞争离子在不同离子浓度的多组分水源相中竞争抑制的效果。在适当稀释多组分水源相后,实现了优异的Pb2+选择性,而与单组分系统的液膜传输相比,效率没有显著降低。通过对blm细胞的研究,证明了所应用的选择分子适用于基于液膜的Pb2+选择性分离方法的发展,本文所讨论的对分离的影响分析和工艺参数的优化可以极大地帮助这一研究。
{"title":"Liquid-liquid extraction and facilitated membrane transport of Pb2+ using a lipophilic acridono-crown ether as carrier","authors":"Ádám Golcs,&nbsp;László Bezúr,&nbsp;Péter Huszthy,&nbsp;Tünde Tóth","doi":"10.1007/s10847-020-01036-4","DOIUrl":"https://doi.org/10.1007/s10847-020-01036-4","url":null,"abstract":"<p>Studies on liquid-liquid extraction and bulk liquid membrane (BLM) technique-based metal ion separation by a previously published Pb<sup>2+</sup>-selective acridono-18-crown-6 ether selector molecule were performed. The effects of the stirring speed, the quality of apolar organic membrane, the counterions of Pb<sup>2+</sup>, the pH of the aqueous phase, the concentration of the source phase, the concentration of the carrier in the BLM and the temperature on the Pb<sup>2+</sup>-separation were investigated. Moreover, the effects of the competitive inhibition due to the presence of Ag<sup>+</sup>, Ca<sup>2+</sup>, Co<sup>2+</sup>, Cu<sup>2+</sup>, K<sup>+</sup>, Mg<sup>2+</sup>, Na<sup>+</sup> and Zn<sup>2+</sup> as competing ions in a multicomponent aqueous source phase of different ion-concentrations were also studied. After a proper dilution of the multicomponent aqueous source phase, excellent Pb<sup>2+</sup>-selectivity was achieved without a significant reduction in the efficiency compared to the liquid membrane transport of single-component systems. Based on the BLM-cell studies the applied selector molecule proved to be suitable for the development of liquid membrane-based Pb<sup>2+</sup>-selective separation methods, which can be greatly aided by the analysis of the effects on the separation and by the optimization of the parameters of the process discussed here.</p>","PeriodicalId":54324,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":"99 1-2","pages":"117 - 129"},"PeriodicalIF":2.3,"publicationDate":"2020-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10847-020-01036-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4814642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Synthesis, optical properties and photherapy applications of gold nanostars 纳米金的合成、光学性质及光疗应用
IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2020-11-11 DOI: 10.1007/s10847-020-01035-5
Pervin Deveci

Phototherapy is a type of medical treatment that involves exposure to ultraviolet-visible (UV–Vis) region or near-infrared (NIR) region light to treat certain medical conditions. Compared to other treatment methods such as chemotherapy and radiotherapy, it attracts a lot of attention today due to its lower cost, more effect on the tumor cell, and less side effects. Today's clinical therapy research shows that combining chemotherapeutic methods and phototherapeutic methods on a single nanostructure increases the therapeutic effect that each method alone has, and this is even more effective in destroying cancer cells. The emergence of nanomaterials recently opens up new opportunities to increase therapeutic efficacy and overcome limitations in current phototherapy techniques. Gold nanostars (GNSs) are a kind of promising photothermal agent recently in the biomedical field with its strong absorption in the NIR field, high photothermal conversion efficiency, excellent photothermal stability, and biocompatibility. In this study, the synthesis methods, optical properties of GNSs, and their current studies on cancer diagnosis and treatments are summarized.

光疗是一种医学治疗,涉及暴露于紫外线-可见(UV-Vis)区域或近红外(NIR)区域的光来治疗某些医疗状况。与化疗、放疗等其他治疗方法相比,它以其成本更低、对肿瘤细胞的作用更大、副作用更小而备受关注。今天的临床治疗研究表明,将化疗方法和光治疗方法结合在一个纳米结构上,可以增加每种方法单独具有的治疗效果,这在破坏癌细胞方面甚至更有效。纳米材料的出现为提高治疗效果和克服当前光疗技术的局限性开辟了新的机会。金纳米星(GNSs)具有近红外吸收强、光热转换效率高、光热稳定性好、生物相容性好等优点,是近年来在生物医学领域应用前景广阔的光热材料。本文综述了GNSs的合成方法、光学性质及其在癌症诊断和治疗中的研究现状。
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引用次数: 8
期刊
Journal of Inclusion Phenomena and Macrocyclic Chemistry
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