Pub Date : 2021-02-25DOI: 10.1007/s10847-021-01052-y
Hyeon Woo Kim, Jeong Zoo Lee, Sang Don Lee, Yangkyu Park, Hunjoo Lee, Jeongmin Yoon, Seungwan Seo, Dong Gil Shin
The present study aims to evaluate the effectiveness of the Transperineal Pelvic Floor Electrical Stimulation (TPFES) system as a treatment option for females with stress urinary incontinence (SUI). A total of 8 females who were diagnosed with SUI were included in the study. All the patients received TPFES and were educated to use it daily for 12 weeks. The patients completed ‘International Consultation on Incontinence Questionnaire-Urinary Incontinence (ICIQ-UI)’ and ‘Overactive Bladder Symptom Score Questionnaire’ before and after applying NPFES at every visit. Age, body mass index (BMI), maximum flow rate, and postvoid residual of each patient were obtained before the study. Repeated-measures ANOVA was performed using the estimates of variables at each visit to evaluate the effectiveness of TPFES in SUI. Also, a linear mixed model was derived to verify the variables that affect the effectiveness of TPFES treatment. The mean age and BMI of the patients were 61.88 ± 16.49 years and 24.62 ± 2.87 kg/m2, respectively. Among the investigated variables, the mean ICIQ-UI total score showed significant change depending on the duration of TPFES treatment (p < 0.001); the mean ICIQ-UI total score tended to decrease as the duration of TPFES treatment increases. The post-hoc test revealed a significant decrease of mean ICIQ-UI total score at 8 weeks and 12 weeks compared to the baseline (p = 0.012 and p = 0.005, respectively). Also, the mean ICIQ-UI total score was significantly affected by the treatment duration of TPFES (p = 0.001). Thus, consistent and long-term use of the TPFES system can be a non-surgical treatment option that effectively improves SUI.
{"title":"Effectiveness of transperineal pelvic floor electrical stimulation system in improving female stress urinary incontinence: a prospective pilot study","authors":"Hyeon Woo Kim, Jeong Zoo Lee, Sang Don Lee, Yangkyu Park, Hunjoo Lee, Jeongmin Yoon, Seungwan Seo, Dong Gil Shin","doi":"10.1007/s10847-021-01052-y","DOIUrl":"10.1007/s10847-021-01052-y","url":null,"abstract":"<div><p>The present study aims to evaluate the effectiveness of the Transperineal Pelvic Floor Electrical Stimulation (TPFES) system as a treatment option for females with stress urinary incontinence (SUI). A total of 8 females who were diagnosed with SUI were included in the study. All the patients received TPFES and were educated to use it daily for 12 weeks. The patients completed ‘International Consultation on Incontinence Questionnaire-Urinary Incontinence (ICIQ-UI)’ and ‘Overactive Bladder Symptom Score Questionnaire’ before and after applying NPFES at every visit. Age, body mass index (BMI), maximum flow rate, and postvoid residual of each patient were obtained before the study. Repeated-measures ANOVA was performed using the estimates of variables at each visit to evaluate the effectiveness of TPFES in SUI. Also, a linear mixed model was derived to verify the variables that affect the effectiveness of TPFES treatment. The mean age and BMI of the patients were 61.88 ± 16.49 years and 24.62 ± 2.87 kg/m<sup>2</sup>, respectively. Among the investigated variables, the mean ICIQ-UI total score showed significant change depending on the duration of TPFES treatment (p < 0.001); the mean ICIQ-UI total score tended to decrease as the duration of TPFES treatment increases. The post-hoc test revealed a significant decrease of mean ICIQ-UI total score at 8 weeks and 12 weeks compared to the baseline (p = 0.012 and p = 0.005, respectively). Also, the mean ICIQ-UI total score was significantly affected by the treatment duration of TPFES (p = 0.001). Thus, consistent and long-term use of the TPFES system can be a non-surgical treatment option that effectively improves SUI.</p></div>","PeriodicalId":54324,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2021-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10847-021-01052-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4963033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-18DOI: 10.1007/s10847-021-01049-7
Grégorio Crini
Paul Karrer (1889–1971), a Swiss organic chemist best known for his research on vitamins, has published more than 1000 articles. In 1919, Karrer became professor of chemistry at the University of Zurich and in the same year he was appointed director of the Chemical Institute in Zurich, where he remained until his retirement in 1959. Karrer’s most famous work was on vitamins, and probably his most important contribution was his demonstration in 1931 that vitamin A was structurally related to carotenoid. Karrer also published important works on natural products, carotenoids and other plant pigments, coenzymes, alkaloids, amino acids, sugars, carbohydrates, polysaccharides, and organometallic compounds. Professor Karrer was awarded the Nobel Prize in chemistry in 1937 for his research into the constitution of carotenoids, flavins and vitamins A and B2, a prize shared with the British chemist Sir Walter Norman Haworth. However, few researchers working in the field of cyclodextrins know that Karrer was also one of the first to take an interest in these molecules. Between 1920 and 1925, he published several studies on the nomenclature, structure and chemistry of dextrin-α and dextrin-β. This historical review, on the occasion of the fiftieth anniversary of his death, aims, on the one hand, to retrace his immense scientific career highlighting selected works on vitamins and alkaloids and, on the other hand, to commemorate his contribution to (cyclo)dextrin chemistry.
{"title":"The contribution of professor Paul Karrer (1889–1971) to dextrins","authors":"Grégorio Crini","doi":"10.1007/s10847-021-01049-7","DOIUrl":"https://doi.org/10.1007/s10847-021-01049-7","url":null,"abstract":"<p>Paul Karrer (1889–1971), a Swiss organic chemist best known for his research on vitamins, has published more than 1000 articles. In 1919, Karrer became professor of chemistry at the University of Zurich and in the same year he was appointed director of the Chemical Institute in Zurich, where he remained until his retirement in 1959. Karrer’s most famous work was on vitamins, and probably his most important contribution was his demonstration in 1931 that vitamin A was structurally related to carotenoid. Karrer also published important works on natural products, carotenoids and other plant pigments, coenzymes, alkaloids, amino acids, sugars, carbohydrates, polysaccharides, and organometallic compounds. Professor Karrer was awarded the Nobel Prize in chemistry in 1937 for his research into the constitution of carotenoids, flavins and vitamins A and B2, a prize shared with the British chemist Sir Walter Norman Haworth. However, few researchers working in the field of cyclodextrins know that Karrer was also one of the first to take an interest in these molecules. Between 1920 and 1925, he published several studies on the nomenclature, structure and chemistry of dextrin-α and dextrin-β. This historical review, on the occasion of the fiftieth anniversary of his death, aims, on the one hand, to retrace his immense scientific career highlighting selected works on vitamins and alkaloids and, on the other hand, to commemorate his contribution to (cyclo)dextrin chemistry.</p>","PeriodicalId":54324,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2021-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10847-021-01049-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4717027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-12DOI: 10.1007/s10847-021-01046-w
Virginia L. Lobatto, Gustavo A. Argüello, Elba I. Buján
{"title":"Direct short-wave photolysis of chlorpyrifos-methyl and chlorpyrifos-methyl oxon in the presence of cyclodextrins","authors":"Virginia L. Lobatto, Gustavo A. Argüello, Elba I. Buján","doi":"10.1007/s10847-021-01046-w","DOIUrl":"https://doi.org/10.1007/s10847-021-01046-w","url":null,"abstract":"","PeriodicalId":54324,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2021-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10847-021-01046-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4489424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-05DOI: 10.1007/s10847-021-01043-z
Hussein Alhendawi, Ernesto Brunet, Elena Rodríguez Payán, Huda Alkahlout
Five novel chiral 2D materials with general formula λ-ZrPO4(OH)1-x(RCOO)x(dmso) have been prepared by covalent anchoring of five different chiral carboxylic acids to the sheets of λ-zirconium phosphate (λ-ZrP), namely (S)-(+)-Mandelic acid (MAN), (R)-(?)-α-Methoxyphenylacetic acid (MPA), (S)-(+)-Ibuprofen (IBU), (S)-(+)-6-Methoxy-α-methyl-2-naphthaleneacetic acid (MMN) and (?)-Menthyloxyacetic acid (MEN). The synthesized materials were characterized by X-ray diffractometry, FT-IR spectrophotometry, elemental and thermogravimetric analyses and polarimetry. The X-ray diffraction patterns revealed that the interlayer separations increase from 1.02?nm (pure λ-ZrP) to 1.31–2.31?nm as a result of the incorporation of the mentioned acids within the interlayer gallery. The polarimetry measurements showed that the synthesized materials have appreciable optical activities suggesting they could have protentional applications in the field of chiral separation techniques.
{"title":"Novel optically active 2D materials based on λ-zirconium phosphate and chiral monocarboxylic acids: Synthesis and characterization","authors":"Hussein Alhendawi, Ernesto Brunet, Elena Rodríguez Payán, Huda Alkahlout","doi":"10.1007/s10847-021-01043-z","DOIUrl":"https://doi.org/10.1007/s10847-021-01043-z","url":null,"abstract":"<p>Five novel chiral 2D materials with general formula λ-ZrPO<sub>4</sub>(OH)<sub>1-x</sub>(RCOO)<sub>x</sub>(dmso) have been prepared by covalent anchoring of five different chiral carboxylic acids to the sheets of λ-zirconium phosphate (<b>λ-ZrP</b>), namely (S)-(+)-Mandelic acid (<b>MAN</b>), (R)-(?)-α-Methoxyphenylacetic acid (<b>MPA</b>), (S)-(+)-Ibuprofen (<b>IBU</b>), (S)-(+)-6-Methoxy-α-methyl-2-naphthaleneacetic acid (<b>MMN</b>) and (?)-Menthyloxyacetic acid (<b>MEN</b>). The synthesized materials were characterized by X-ray diffractometry, FT-IR spectrophotometry, elemental and thermogravimetric analyses and polarimetry. The X-ray diffraction patterns revealed that the interlayer separations increase from 1.02?nm (pure <b>λ-ZrP</b>) to 1.31–2.31?nm as a result of the incorporation of the mentioned acids within the interlayer gallery. The polarimetry measurements showed that the synthesized materials have appreciable optical activities suggesting they could have protentional applications in the field of chiral separation techniques.</p>","PeriodicalId":54324,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2021-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10847-021-01043-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4204376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Herein, we investigated the inclusion complexation of a fluorescent probe [4′,6-diamidino-2-phenylindole (DAPI)]?using various cyclodextrins (CDs) and cucurbit[7]uril (CB7). Using the?continuous variation method, DAPI was found to form a 1:1 inclusion complex with CDs and CB7. 1H-NMR and 2D ROESY (1H-1H rotating frame nuclear Overhauser effect) spectroscopy indicated that the inclusion of DAPI by the CDs and CB7 occurs via the encapsulation of the phenyl group and indole moiety of DAPI. The stability of the CB7?inclusion complex was higher than?that of the CDs: the stability was attributed to the extra interaction formed between the dicationic dye (DAPI) and polar carbonyl groups at the portals of CB7. Furthermore, we determined the fluorescence quantum yield (Φ) of the inclusion complexes. The Φ values of DAPI were significantly enhanced upon its inclusion by CB7 and increased as the empirical solvent polarity parameter (ET(30)) decreased. Based on these results, we concluded that the polarity of the microenvironment and protonation ability of the excited state of DAPI play important roles in emission efficiency.
{"title":"Inclusion complexation of 4′,6-diamidino-2-phenylindole (DAPI) with cucurbit[7]uril and cyclodextrins (native β-, 2,6-di-O-methylated β-, and γ-cyclodextrin): characteristic inclusion behaviour and fluorescence enhancement","authors":"Yoshimi Sueishi, Seiya Hagiwara, Naoya Inazumi, Tadashi Hanaya","doi":"10.1007/s10847-020-01042-6","DOIUrl":"https://doi.org/10.1007/s10847-020-01042-6","url":null,"abstract":"<p>Herein, we investigated the inclusion complexation of a fluorescent probe [4′,6-diamidino-2-phenylindole (DAPI)]?using various cyclodextrins (CDs) and cucurbit[7]uril (CB7). Using the?continuous variation method, DAPI was found to form a 1:1 inclusion complex with CDs and CB7. <sup>1</sup>H-NMR and 2D ROESY (<sup>1</sup>H-<sup>1</sup>H rotating frame nuclear Overhauser effect) spectroscopy indicated that the inclusion of DAPI by the CDs and CB7 occurs via the encapsulation of the phenyl group and indole moiety of DAPI. The stability of the CB7?inclusion complex was higher than?that of the CDs: the stability was attributed to the extra interaction formed between the dicationic dye (DAPI) and polar carbonyl groups at the portals of CB7. Furthermore, we determined the fluorescence quantum yield (Φ) of the inclusion complexes. The Φ values of DAPI were significantly enhanced upon its inclusion by CB7 and increased as the empirical solvent polarity parameter (E<sub>T</sub>(30)) decreased. Based on these results, we concluded that the polarity of the microenvironment and protonation ability of the excited state of DAPI play important roles in emission efficiency.</p>","PeriodicalId":54324,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2021-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10847-020-01042-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4571601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-14DOI: 10.1007/s10847-020-01039-1
Asma Hamedi, Anastasia Anceschi, Francesco Trotta, Mahdi Hasanzadeh, Fabrizio Caldera
We present a rapid and surfactant-free temperature-assisted synthesis route to prepare γ-cyclodextrin-based metal–organic framework (γ-CD-MOF). The cubic crystals of the CD-MOF with an average edge length of 10–15 μm, specific surface area of 775?m2 g?1 and total pore volume of 0.229?cm3 g?1 were synthesized in much shorter time than conventional CD-MOFs. To show the efficiency of the synthesized CD-MOF as adsorbent of gas, the uptake of CO2 at different temperature and pressure was investigated. It is shown that the CO2 uptake increases with increasing pressure and decreasing temperature. Further microgravimetric investigation on gas adsorption at low pressure demonstrated superior gas uptake (ca. 147?mg g?1) than previous reports. At the maximum equilibrium pressure, the uptake amounts of CO2 were found to be 326 and 268?mg g?1 at 303 and 323?K, respectively. The synthesized CD-MOF has great potential to be used in gas storage and separation applications.
提出了一种快速、无表面活性剂的温度辅助合成γ-环糊精基金属有机骨架(γ-CD-MOF)的方法。CD-MOF的立方晶体平均边长为10 ~ 15 μm,比表面积为775?m2 g ?总孔隙体积为0.229?立方厘米g ?与传统的cd - mof相比,1的合成时间大大缩短。为了证明合成的CD-MOF作为气体吸附剂的效率,研究了不同温度和压力下CD-MOF对CO2的吸收率。结果表明,CO2吸收量随压力的增加和温度的降低而增加。进一步的气体吸附微重力研究表明,在低压下气体吸收率更高(约147?Mg ?1)。在最大平衡压力下,CO2的吸收量分别为326和268?mg g ?303和323的1个?分别K。合成的CD-MOF在气体储存和分离方面具有很大的应用潜力。
{"title":"Rapid temperature-assisted synthesis of nanoporous γ-cyclodextrin-based metal–organic framework for selective CO2 adsorption","authors":"Asma Hamedi, Anastasia Anceschi, Francesco Trotta, Mahdi Hasanzadeh, Fabrizio Caldera","doi":"10.1007/s10847-020-01039-1","DOIUrl":"https://doi.org/10.1007/s10847-020-01039-1","url":null,"abstract":"<p>We present a rapid and surfactant-free temperature-assisted synthesis route to prepare γ-cyclodextrin-based metal–organic framework (γ-CD-MOF). The cubic crystals of the CD-MOF with an average edge length of 10–15 μm, specific surface area of 775?m<sup>2</sup> g<sup>?1</sup> and total pore volume of 0.229?cm<sup>3</sup> g<sup>?1</sup> were synthesized in much shorter time than conventional CD-MOFs. To show the efficiency of the synthesized CD-MOF as adsorbent of gas, the uptake of CO<sub>2</sub> at different temperature and pressure was investigated. It is shown that the CO<sub>2</sub> uptake increases with increasing pressure and decreasing temperature. Further microgravimetric investigation on gas adsorption at low pressure demonstrated superior gas uptake (ca. 147?mg g<sup>?1</sup>) than previous reports. At the maximum equilibrium pressure, the uptake amounts of CO<sub>2</sub> were found to be 326 and 268?mg g<sup>?1</sup> at 303 and 323?K, respectively. The synthesized CD-MOF has great potential to be used in gas storage and separation applications.</p>","PeriodicalId":54324,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2021-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10847-020-01039-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4865290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-14DOI: 10.1007/s10847-020-01022-w
Asmita B. Jarange, Sanhita V. Patil, Dipalee D. Malkhede, Shreya M. Deodhar, Vinod S. Nandre, Sulakshana V. Athare, Kisan M. Kodam, Shridhar P. Gejji
The inclusion complexes of tenofovir disoproxil fumarate (TDF) with p-sulfonato-calix[4]arene (SCX4) and p-sulfanatothiacalix[4]arene (TSCX4) macrocycles are characterized through an array of experiments including 1H NMR, NOESY, HPLC, HRMS, FT-IR and PXRD in conjunction with the density functional theory. An encapsulation of TDF within SCX4 and TSCX4 macrocycles conduce 1:1 complexes those prevail over 1:2 or 1:3 Stoichiometries which exhibis distinct structural features. A loss of crystallinity accompanying the complexation ascertains the inclusion of the guest within the macrocycle. A comparison of the measured 13C NMR spectra of the complexes with individual hosts ascertains the cone conformation of SCX4 in such complexes as in its free state. It has been demonstrated that the TDF guest penetrates deeply within the cavity of SCX4 facilitating the hydrogen bonding interactions between adenine protons and the hydroxyl as well as methylene protons of the macrocycle. The measured 1H NMR spectra thus reveal large upfield signals (δ 8.35, 8.48?ppm) for adenine protons of the SCX4 complex. On the other hand, the partial encapsulation of TDF in TSCX4 reflects in the deshielding of hydroxyl protons in the measured 1H NMR spectra. The characteristic C=N and SO stretching vibrations in the infrared spectra engender’frequency shifts’ in the opposite directions compared to the individual host or guest. A simple reverse phase high performance liquid chromatography method is presented. The adenine encapsulation further has been qualitatively correlated with MRSA activities.
{"title":"p-Sulfonatocalixarene versus p-thiasulfonatocalixarene: encapsulation of tenofovir disoproxil fumarate and implications to ESI-MS, HPLC, NMR, DFT and anti-MRSA activities","authors":"Asmita B. Jarange, Sanhita V. Patil, Dipalee D. Malkhede, Shreya M. Deodhar, Vinod S. Nandre, Sulakshana V. Athare, Kisan M. Kodam, Shridhar P. Gejji","doi":"10.1007/s10847-020-01022-w","DOIUrl":"https://doi.org/10.1007/s10847-020-01022-w","url":null,"abstract":"<p>The inclusion complexes of tenofovir disoproxil fumarate (TDF) with <i>p</i>-sulfonato-calix[4]arene (SCX4) and <i>p</i>-sulfanatothiacalix[4]arene (TSCX4) macrocycles are characterized through an array of experiments including <sup>1</sup>H NMR, NOESY, HPLC, HRMS, FT-IR and PXRD in conjunction with the density functional theory. An encapsulation of TDF within SCX4 and TSCX4 macrocycles conduce 1:1 complexes those prevail over 1:2 or 1:3 Stoichiometries which exhibis distinct structural features. A loss of crystallinity accompanying the complexation ascertains the inclusion of the guest within the macrocycle. A comparison of the measured <sup>13</sup>C NMR spectra of the complexes with individual hosts ascertains the cone conformation of SCX4 in such complexes as in its free state. It has been demonstrated that the TDF guest penetrates deeply within the cavity of SCX4 facilitating the hydrogen bonding interactions between adenine protons and the hydroxyl as well as methylene protons of the macrocycle. The measured <sup>1</sup>H NMR spectra thus reveal large upfield signals (δ 8.35, 8.48?ppm) for adenine protons of the SCX4 complex. On the other hand, the partial encapsulation of TDF in TSCX4 reflects in the deshielding of hydroxyl protons in the measured <sup>1</sup>H NMR spectra. The characteristic C=N and SO stretching vibrations in the infrared spectra engender’frequency shifts’ in the opposite directions compared to the individual host or guest. A simple reverse phase high performance liquid chromatography method is presented. The adenine encapsulation further has been qualitatively correlated with MRSA activities.</p>","PeriodicalId":54324,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2021-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10847-020-01022-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4573540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.1007/s10847-020-01038-2
Sandip Pawar, Pravin Shende
{"title":"Design and optimization of cyclodextrin-based nanosponges of antimalarials using central composite design for dry suspension","authors":"Sandip Pawar, Pravin Shende","doi":"10.1007/s10847-020-01038-2","DOIUrl":"https://doi.org/10.1007/s10847-020-01038-2","url":null,"abstract":"","PeriodicalId":54324,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10847-020-01038-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4025750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.1007/s10847-020-01037-3
Benita Barton, Mino R. Caira, Daniel V. Jooste, Eric C. Hosten
In this communication, we reveal that the host compound trans-N,N′-bis(9-phenyl-9-xanthenyl)cyclohexane-1,4-diamine (1,4-DAX) possesses the ability to purify 2-methylpyridine (2MP)/pyridine (PYR) and 3-methylpyridine (3MP)/PYR binary mixtures by enclathrating PYR almost exclusively, even when such mixtures contained as little as approximately 30% PYR. For example, when these solutions were prepared with equimolar quantities of the two guests, complexes contained as much as 92.4 and 96.4% PYR, respectively. Furthermore, 1,4-DAX was capable of forming a mixed complex with as high as 87.8% PYR from an equimolar ternary mixture containing 2MP, 3MP and PYR through host?guest complexation. This work complements that of trans-N,N′-bis(9-phenyl-9-xanthenyl)cyclohexane-1,2-diamine (1,2-DAX) and trans-N,N′-bis(9-phenyl-9-thioxanthenyl)cyclohexane-1,2-diamine (1,2-DAT), disclosed in a previous submission, where 4-methylpyridine (4MP) and 2MP, correspondingly, were the preferred guest solvents. Interestingly, trans-N,N′-bis(9-phenyl-9-thioxanthenyl)cyclohexane-1,4-diamine (1,4-DAT) showed no inclusion tendencies under such conditions. Successfully-formed inclusion complexes were subjected to crystal X-ray diffraction analyses in order to understand the preference of 1,4-DAX for 4MP and PYR. Thermal analyses of these complexes were, however, less informative.
{"title":"Alternative purification protocols of mixed pyridines in the presence of trans-N,N′-bis(9-phenyl-9-xanthenyl)cyclohexane-1,4-diamine","authors":"Benita Barton, Mino R. Caira, Daniel V. Jooste, Eric C. Hosten","doi":"10.1007/s10847-020-01037-3","DOIUrl":"https://doi.org/10.1007/s10847-020-01037-3","url":null,"abstract":"<p>In this communication, we reveal that the host compound <i>trans-N,N′</i>-bis(9-phenyl-9-xanthenyl)cyclohexane-1,4-diamine (1,4-DAX) possesses the ability to purify 2-methylpyridine (2MP)/pyridine (PYR) and 3-methylpyridine (3MP)/PYR binary mixtures by enclathrating PYR almost exclusively, even when such mixtures contained as little as approximately 30% PYR. For example, when these solutions were prepared with equimolar quantities of the two guests, complexes contained as much as 92.4 and 96.4% PYR, respectively. Furthermore, 1,4-DAX was capable of forming a mixed complex with as high as 87.8% PYR from an equimolar ternary mixture containing 2MP, 3MP and PYR through host?guest complexation. This work complements that of <i>trans-N,N′</i>-bis(9-phenyl-9-xanthenyl)cyclohexane-1,2-diamine (1,2-DAX) and <i>trans-N,N′</i>-bis(9-phenyl-9-thioxanthenyl)cyclohexane-1,2-diamine (1,2-DAT), disclosed in a previous submission, where 4-methylpyridine (4MP) and 2MP, correspondingly, were the preferred guest solvents. Interestingly, <i>trans-N,N′</i>-bis(9-phenyl-9-thioxanthenyl)cyclohexane-1,4-diamine (1,4-DAT) showed no inclusion tendencies under such conditions. Successfully-formed inclusion complexes were subjected to crystal X-ray diffraction analyses in order to understand the preference of 1,4-DAX for 4MP and PYR. Thermal analyses of these complexes were, however, less informative.</p>","PeriodicalId":54324,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10847-020-01037-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4025391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-12-21DOI: 10.1007/s10847-020-01036-4
Ádám Golcs, László Bezúr, Péter Huszthy, Tünde Tóth
Studies on liquid-liquid extraction and bulk liquid membrane (BLM) technique-based metal ion separation by a previously published Pb2+-selective acridono-18-crown-6 ether selector molecule were performed. The effects of the stirring speed, the quality of apolar organic membrane, the counterions of Pb2+, the pH of the aqueous phase, the concentration of the source phase, the concentration of the carrier in the BLM and the temperature on the Pb2+-separation were investigated. Moreover, the effects of the competitive inhibition due to the presence of Ag+, Ca2+, Co2+, Cu2+, K+, Mg2+, Na+ and Zn2+ as competing ions in a multicomponent aqueous source phase of different ion-concentrations were also studied. After a proper dilution of the multicomponent aqueous source phase, excellent Pb2+-selectivity was achieved without a significant reduction in the efficiency compared to the liquid membrane transport of single-component systems. Based on the BLM-cell studies the applied selector molecule proved to be suitable for the development of liquid membrane-based Pb2+-selective separation methods, which can be greatly aided by the analysis of the effects on the separation and by the optimization of the parameters of the process discussed here.
{"title":"Liquid-liquid extraction and facilitated membrane transport of Pb2+ using a lipophilic acridono-crown ether as carrier","authors":"Ádám Golcs, László Bezúr, Péter Huszthy, Tünde Tóth","doi":"10.1007/s10847-020-01036-4","DOIUrl":"https://doi.org/10.1007/s10847-020-01036-4","url":null,"abstract":"<p>Studies on liquid-liquid extraction and bulk liquid membrane (BLM) technique-based metal ion separation by a previously published Pb<sup>2+</sup>-selective acridono-18-crown-6 ether selector molecule were performed. The effects of the stirring speed, the quality of apolar organic membrane, the counterions of Pb<sup>2+</sup>, the pH of the aqueous phase, the concentration of the source phase, the concentration of the carrier in the BLM and the temperature on the Pb<sup>2+</sup>-separation were investigated. Moreover, the effects of the competitive inhibition due to the presence of Ag<sup>+</sup>, Ca<sup>2+</sup>, Co<sup>2+</sup>, Cu<sup>2+</sup>, K<sup>+</sup>, Mg<sup>2+</sup>, Na<sup>+</sup> and Zn<sup>2+</sup> as competing ions in a multicomponent aqueous source phase of different ion-concentrations were also studied. After a proper dilution of the multicomponent aqueous source phase, excellent Pb<sup>2+</sup>-selectivity was achieved without a significant reduction in the efficiency compared to the liquid membrane transport of single-component systems. Based on the BLM-cell studies the applied selector molecule proved to be suitable for the development of liquid membrane-based Pb<sup>2+</sup>-selective separation methods, which can be greatly aided by the analysis of the effects on the separation and by the optimization of the parameters of the process discussed here.</p>","PeriodicalId":54324,"journal":{"name":"Journal of Inclusion Phenomena and Macrocyclic Chemistry","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2020-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10847-020-01036-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4814642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}