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The supramolecularly complexes of calix[4]arene derivatives toward favipiravir antiviral drug (used to treatment of COVID-19): a DFT study on the geometry optimization, electronic structure and infrared spectroscopy of adsorption and sensing 卡利克[4]炔衍生物与法非拉韦抗病毒药物(用于治疗 COVID-19)的超分子配合物:关于吸附和传感的几何优化、电子结构和红外光谱的 DFT 研究
IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-06-05 DOI: 10.1007/s10847-021-01087-1
Numan Yuksel, Ahmet Köse, M. Ferdi Fellah

While the world is in search of a vaccine that can cure COVID-19 disease, favipiravir is the most commonly used antiviral drug in the treatment of patients during the pandemic process. In this study, we investigated the host–guest interaction between the popular supramolecule calix[4]arene derivatives and the favipiravir drug by using the DFT (Density Functional Theory) method. The B3LYP hybrid method and 6-31G (d,p) basis set were utilized to determine the optimized structures of the host and guest molecules and their complexes. The negative adsorption energy (∆E) and adsorption enthalpy (∆H) calculated for the complexes formed between calix[4]arene compounds and favipiravir drug molecule mentioned that adsorption of favipiravir molecule was an exothermic process on calix[4]arene structures. On the other hand, among the calixarene derivatives in the study, Gibbs free energy change (∆G) value for the adsorption was only negative on calix[4]arene4 molecule. The infrared spectroscopy (IR) calculations were performed by examining the C=O, O–H and NH2 vibrational frequencies to see the adsorption behavior in the favipiravir-calix[4]arene complex. After adsorption of the favipiravir molecule, HOMO–LUMO gap values decreased significantly for the structures and therefore electrical conductivity increased proportionally. In addition, sensor response factors, Fermi energy levels and workfunction changes of calix[4]arene derivatives were calculated and examined. Charge transfer between the four calix[4]arene compounds and the favipiravir molecule has occurred after adsorption. This attributes that calix[4]arene derivatives can be used as a well-suited favipiravir sensor (electronic and workfunction) and adsorbent at room temperature. Based on the calculations made to see the solvent effect on the adsorption of favipiravir it was determined that it did not affect the interaction between the drug molecule and the calix[4]arene compound too much and the adsorption energy turned into a slightly less negative value.

当全世界都在寻找能够治愈 COVID-19 疾病的疫苗时,法匹拉韦是大流行过程中治疗患者最常用的抗病毒药物。在本研究中,我们采用 DFT(密度泛函理论)方法研究了流行的超分子卡利克[4]炔衍生物与法非拉韦药物之间的主客体相互作用。利用 B3LYP 混合方法和 6-31G (d,p) 基集确定了主分子、客分子及其复合物的优化结构。计算得出的卡利克[4]炔化合物与法非拉韦药物分子形成的复合物的负吸附能(ΔE)和吸附焓(ΔH)表明,法非拉韦分子在卡利克[4]炔结构上的吸附是一个放热过程。另一方面,在研究的钙[4]烯衍生物中,吸附的吉布斯自由能变化(ΔG)值仅在钙[4]烯4 分子上为负值。通过研究 C=O、O-H 和 NH2 的振动频率,进行了红外光谱(IR)计算,以了解法非拉韦酯-钙力[4]炔复合物的吸附行为。吸附了法非拉韦分子后,这些结构的 HOMO-LUMO 间隙值明显降低,因此导电率也相应提高。此外,还计算并研究了卡利克[4]炔衍生物的传感器响应因子、费米能级和功函数变化。四种卡利克[4]炔化合物和法非拉韦分子在吸附后发生了电荷转移。这说明钙[4]炔衍生物可在室温下用作非常适合的法非拉韦传感器(电子功能和工作功能)和吸附剂。根据对溶剂对法比拉韦吸附影响的计算,可以确定溶剂不会对药物分子和卡利克[4]炔化合物之间的相互作用产生太大影响,吸附能也变成了一个稍小的负值。
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引用次数: 0
Multichromatic fluorescence towards aberrant proteinaceous aggregates utilizing benzimidazole-based ICT fluorophores 利用苯并咪唑基ICT荧光团对异常蛋白聚集体的多色荧光
IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-06-04 DOI: 10.1007/s10847-021-01085-3
Jusung An, Paramesh Jangili, Sungsu Lim, Yun Kyung Kim, Peter Verwilst, Jong Seung Kim

The pathological origin of Alzheimer’s disease (AD) remains uncharted terrain, despite intensive investigation. Discriminating aberrant proteinaceous deposits, such as β-amyloid (Aβ) and (hyperphosphorylated) tau protein by imaging methods, is a vital tool to support investigations towards the network of interacting features that results in AD pathology. In this context, multispectral fluorescence imaging (MSFI) has drawn much attention enabling the distinction of several analytes with merely a single fluorophore emitting a multichromatic fluorescent signal. Herein, we developed three kinds of benzimidazole-derived fluorescent dyes, BZ1BZ3. The photophysical properties and intramolecular charge transfer (ICT) characteristics of the probes were evaluated in various solvents. Furthermore, a benzimidazole-associated polar-sensitivity displayed multichromatic behavior and enabled the visualization of minute differences in microenvironmental polarity between Aβ and tau aggregates, resulting in different maximal fluorescent emission wavelengths. Indeed, BZ2 demonstrated an approximately 30 nm bathochromic shift in maximal fluorescent emission. All these observations offer a potential for the development of a future generation of benzimidazole-derived ICT-based fluorescent probes.

阿尔茨海默病(AD)的病理起源仍然是未知的领域,尽管深入的研究。通过成像方法区分异常蛋白沉积,如β-淀粉样蛋白(a β)和(过度磷酸化的)tau蛋白,是支持研究导致AD病理的相互作用特征网络的重要工具。在这种情况下,多光谱荧光成像(MSFI)引起了人们的广泛关注,它能够仅用单个荧光团发射多色荧光信号来区分几种分析物。本研究开发了三种苯并咪唑衍生的荧光染料BZ1-BZ3。考察了探针在不同溶剂中的光物理性质和分子内电荷转移(ICT)特性。此外,苯并咪唑相关的极性灵敏度显示出多色行为,并使a β和tau聚集体之间微环境极性的微小差异可视化,从而导致不同的最大荧光发射波长。事实上,BZ2在最大荧光发射中表现出约30 nm的色移。所有这些观察结果为未来一代苯并咪唑衍生的基于ict的荧光探针的开发提供了潜力。
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引用次数: 6
Improved precious metal adsorption by introduction of carboxylic acid groups on methylene crosslinked calix[4]arene resin matrix 引入羧基改善亚甲基交联杯[4]芳烃树脂基体对贵金属的吸附
IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-06-01 DOI: 10.1007/s10847-021-01079-1
Yoga Priastomo, Shintaro Morisada, Hidetaka Kawakita, Keisuke Ohto, Jumina Jumina

A methylene crosslinked calix[4]arene tetracarboxylic acid resin that exhibits high precious metal adsorption properties was prepared. The maximum loading capacity of this resin was compared with that of an unmodified methylene crosslinked calix[4]arene resin to verify its applicability for platinum and palladium adsorption. The introduction of multiple acetic acid groups improved the adsorption capacity for divalent palladium, while that for tetravalent platinum was slightly suppressed. The newly obtained capacity of palladium was 1.17 mmol/g, while that of platinum was 0.23 mmol/g. The stoichiometry of Pd(II) to the calix[4]arene tetracarboxylic acid monomer in the methylene crosslinked tetracarboxylic acid calix[4]arene resin was found to be 1:2, while that of Pt(IV) to the same monomer was 9:1. Linear and non-linear methods were applied to evaluate the fitting of the Langmuir and Freundlich models for the studied adsorption isotherm. The results showed that the adsorption isotherm was consistently fitted by the Langmuir model. Further, the non-linear method was found to be more suitable for obtaining the isotherm parameters.

制备了一种具有高贵金属吸附性能的亚甲基交联杯[4]芳烃四羧酸树脂。将该树脂与未改性亚甲基交联杯[4]芳烃树脂的最大负载能力进行比较,验证其吸附铂和钯的适用性。多个乙酸基团的引入提高了对二价钯的吸附能力,而对四价铂的吸附能力略有抑制。钯的新容量为1.17 mmol/g,铂的新容量为0.23 mmol/g。在亚甲基交联四羧酸杯[4]芳烃树脂中,钯(II)与杯[4]芳烃四羧酸单体的化学计量比为1:2,铂(IV)与同一单体的化学计量比为9:1。采用线性和非线性方法对Langmuir和Freundlich吸附等温线模型的拟合性进行了评价。结果表明,吸附等温线符合Langmuir模型。此外,非线性方法更适合于等温线参数的获取。
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引用次数: 3
Jacques Vicens: his life in research 雅克·维森斯:他的研究生涯
IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-05-24 DOI: 10.1007/s10847-021-01081-7
Quentin Vicens, Yang Kim, Jack Harrowfield
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引用次数: 0
Crystal structure of self-assembled inclusion complex of symmetric dicyclohexanocucurbit[6]uril with 1H-benzotriazole 对称双环己六环脲[6]与1h -苯并三唑自组装包合物的晶体结构
IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-05-21 DOI: 10.1007/s10847-021-01076-4
Yan-Mei Jin, Dao-Fa Jiang, Ye Meng, Jie Gao, Jun Zheng, Pei-Hua Ma

The host and guest supramolecular interactions between symmetric dicyclohexanocucurbit[6]uril (CyH2Q[6]) and 1H-benzotriazole (BTA) were investigated using nuclear magnetic resonance spectroscopy, isothermal titration calorimetry (ITC), MALDI-TOF mass spectrometry and single-crystal X-ray diffraction analysis. From the experimental results, it was concluded that there was a 1:1 mode of inclusion in BTA@CyH2Q[6]. In addition, the benzene ring of the BTA molecule entered the cavity of CyH2Q[6], while the triazole part was at the port of the CyH2Q[6], forming a supramolecular framework. According to ITC, the complexation process for BTA with CyH2Q[6] is exothermic and mainly driven by enthalpy.

采用核磁共振波谱、等温滴定量热法(ITC)、MALDI-TOF质谱和单晶x射线衍射分析等方法,研究了对称双环己六脲[6]脲(CyH2Q[6])与1h -苯并三唑(BTA)之间的主、guest超分子相互作用。从实验结果可以得出BTA@CyH2Q中存在1:1的包合模式[6]。此外,BTA分子的苯环进入CyH2Q的空腔[6],而三唑部分位于CyH2Q的端口[6],形成了一个超分子框架。根据ITC, BTA与CyH2Q的络合过程[6]是放热的,主要由焓驱动。
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引用次数: 3
A computational study on the complexation of bisbenzimidazolyl derivatives with cucurbituril and cyclohexylcucurbituril 双苯并咪唑衍生物与葫芦脲和环己基葫芦脲络合的计算研究
IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-05-15 DOI: 10.1007/s10847-021-01078-2
N. S. Venkataramanan, A. Suvitha, R. Sahara, Y. Kawazoe

The binding properties of 1,ω-bisbenzimidazolyl derivatives with cucurbit[6]uril (Q[6]) and cyclohexanocucurbit[6]uril (Cy6Q[6]) host, for 1:1 stoichiometry, have been studied using density functional theory. The distance between the two benimidazole acidic hydrogen’s along with the flexible butyl spacer group play a vital role in the complexation with host. The energetic analysis exhibits strong complexation ability of guests with Q[6] than Cy6Q[6] host. The computed enthalpy and free energy change were negative indicating the encapsulation process to be spontaneous and thermodynamically favorable and enthalpy driven. The global reactivity descriptors based charge transfer calculations show that charge transfer occurs from the guest to host molecule which was supported by the electron density difference map. The main factors for the higher stability of stable complex was the presence of C–H····O=C hydrogen bonding interactions in addition to the weak C···O, C···N, N···O, C···H, H···N type of interactions. AIM topological parameters and NCI analysis reveals the existence of weak interaction, mainly of electrostatic in nature and more number of hydrogen bonds are present in stable complexes. EDA analysis demonstrates the presence of noncovalent and electrostatic interaction with partial covalent character in the encapsulated complexes. The lower stability of Cy6Q[6] complexes compare to Q[6] are due to the presence of positive Vs,max values of cyclohexanone methylene hydrogen’s on Cy6Q[6] host.

Graphic abstract

利用密度泛函理论研究了1,ω-双苯并咪唑衍生物与葫芦[6]脲(Q[6])和环己六葫芦[6]脲(Cy6Q[6])宿主在1:1化学计量下的结合特性。两个苯咪唑酸氢之间的距离以及柔性丁基间隔基团对与宿主络合起着至关重要的作用。能量分析表明,Q[6]的嘉宾比Cy6Q[6]的嘉宾络合能力强。计算得到的焓和自由能变化均为负,表明包封过程是自发的、热力学有利的、焓驱动的。基于全局反应性描述符的电荷转移计算表明,电子密度差图支持从客体分子到宿主分子的电荷转移。稳定配合物稳定性较高的主要因素是除了弱的C··O、C··N、N··O、C··H、H··N型相互作用外,还存在C - H··O=C的氢键相互作用。AIM拓扑参数和NCI分析揭示了弱相互作用的存在,本质上主要是静电相互作用,稳定配合物中存在较多的氢键。EDA分析表明,包封的配合物存在非共价和部分共价静电相互作用。与Q[6]相比,Cy6Q[6]配合物的稳定性较低,这是由于Cy6Q[6]宿主上存在正的v值,即环己酮亚甲基氢的最大值。图形抽象
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引用次数: 2
Host−guest inclusion systems of nicotine with acyclic cucurbit[n]urils for controlled heat releases 含无环葫芦[n]刺的尼古丁主-客体包合系统,用于控制热量释放
IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-05-10 DOI: 10.1007/s10847-021-01073-7
Jing Liu, Liyuan Chen, Gaofeng Dong, Jing Yang, Panyong Zhu, Xiali Liao, Baoxing Wang, Bo Yang

The thermal stability and slow release of nicotine are crucial to its shelf-life and applications. In this article, three kinds of acyclic cucurbit[n]urils (ACBs) were synthesized with cation or anion arms, benzene or naphthalene wall, aiming to handily adjust the binding ability of ACBs. The complexation behaviors and binding affinity of nicotine with ACBs in aqueous and solid state were investigated via fluorescence spectroscopy, NMR, XRD, FT−IR and DSC, which revealed the formation of host−guest inclusion systems with different stability constants (Ks). The heat-controlled release in solid state of the complexes were studied via 1H NMR spectra and TGA. Compared to nicotine, the complexes exhibited less volatility, longer retention time, better water solubility and heat-controlled release. It is our special interest to explore the binding behaviors of all kinds of ACBs with nicotine, controlled heat releases of nicotine with ACBs, which will provide a useful approach to achieve novel formulation of nicotine inclusion complexes used for products including nicotine with controlled heat releases.

尼古丁的热稳定性和缓释对其保质期和应用至关重要。本文以阳离子臂或阴离子臂、苯壁或萘壁合成了三种无环葫芦[n]urils (ACBs),目的是方便地调节ACBs的结合能力。通过荧光光谱、NMR、XRD、FT - IR和DSC等手段研究了烟碱与ACBs在水溶液和固体状态下的络合行为和结合亲和力,揭示了烟碱与ACBs在水溶液和固体状态下形成的具有不同稳定常数(Ks)的主-客体包合体系。通过1H NMR和TGA对配合物的固态热控释放进行了研究。与烟碱相比,该配合物具有挥发性小、保留时间长、水溶性好、热控释等特点。研究各种烟碱复合物与尼古丁的结合行为、烟碱与烟碱的控热释放,将为制备含烟碱的控热释放产品的新型烟碱包合物提供有益的途径。
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引用次数: 6
Uranyl complexes of p-t-butylcalix[8]arene as H-bond acceptors—subtle effects of the donors 对叔丁基杯[8]芳烃的铀酰配合物作为氢键受体——给体的微妙影响
IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-05-10 DOI: 10.1007/s10847-021-01075-5
Jack M. Harrowfield, Mark I. Ogden, Alexandre N. Sobolev, Allan H. White

Leaving a mixture of excess N,N,N′,N′-tetramethyl-1,4-butanediamine (Me4BDA) with p-t-butylcalix[8]arene (L) and [(UO2)(dmso)5](ClO4)2 in a 1:2 ratio in acetonitrile solution to stand for an extended period resulted in the deposition of a mixture of three different crystalline materials. Single crystal X-ray structural studies were carried out to determine that the three materials were the solvated uncomplexed macrocycle L.1.5MeCN, and two uranyl complexes. These were formulated as (Me4BDAH2)2+[(HO)(UO2)2(L-5H)]2–·9MeCN·H2O and (Me4BDAH2)2+[HO(UO2)2{L-5H)]2–·(Me3BDAH)+[H2O(UO2)2(L-5H)]·Me4BDA·14MeCN·H2O·CH3OH respectively. In contrast to analogous systems based on 1,2-ethanediamine and 1,3-propanediamine derivatives, extension of the chain length separating the N-centres to (CH2)4 in the present systems has resulted in the formation of polymeric chains where the calixuranate anions are linked by H-bond acceptance from diammonium units. These links are still not completely direct and pass in part through solvent bridges. Direct double interactions do occur in the inverse situation where the calixarene acts as an H-bond donor to neutral 1,4-butanediamine species but lead only to dimerisation.

将过量的N,N,N ',N ' -四甲基-1,4-丁二胺(Me4BDA)与对叔丁基杯[8]芳烃(L)和[(UO2)(dmso)5](ClO4)2按1:2的比例混合在乙腈溶液中放置一段时间,导致三种不同结晶材料的混合物沉积。通过单晶x射线结构研究,确定了这三种材料分别为溶剂化的未络合大环l .1.5 men和两种铀酰配合物。分子式分别为(Me4BDAH2)2+[(HO)(UO2)2(L-5H)]2 -·9MeCN·H2O和(Me4BDAH2)2+[HO(UO2)2{L-5H)]2 -·(Me3BDAH)+[H2O(UO2)2(L-5H)]−·Me4BDA·14MeCN·H2O·CH3OH。与基于1,2-乙二胺和1,3-丙二胺衍生物的类似体系相比,在目前的体系中,将n -中心分离到(CH2)4的链长延长导致形成聚合链,其中杯铀酸盐阴离子通过氢键接受与二铵单元连接。这些联系仍然不是完全直接的,部分通过溶剂桥。直接的双重相互作用确实发生在相反的情况下,即杯芳烃作为中性的1,4-丁二胺物种的氢键供体,但只导致二聚化。
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引用次数: 0
Why heptakis(2,3-di-O-acetyl)-β-cyclodextrin can separate terbutaline enantiomers better than β-cyclodextrin: nonbonding and hydrophobic interactions 为什么heptakis(2,3-二- o -乙酰基)-β-环糊精比β-环糊精更能分离特布他林对映体:非键和疏水相互作用
IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-05-02 DOI: 10.1007/s10847-021-01072-8
Ran Dou, Ke Chen, Guoli Chi, Jun Luo, Chung F. Wong, Baojing Zhou

The chiral separation of terbutaline (TB) using β-cyclodextrins (β-CD) and its derivatives has aroused intensive interest. Herein, the enantioseparation mechanisms of β-CD and heptakis(2,3-di-O-acetyl)-β-CD (HAD-β-CD) towards TB are investigated by a molecular dynamics/quantum mechanics/continuum solvent model (MD/QM/CSM) approach based on the experimental data. One of the two experimentally predicted binding modes of HAD-β-CD/TB is confirmed by our approach and ascribed to the R-complex. R-TB is compactly included by HAD-β- CD: the aromatic ring is within the CD cavity, while the alkyl moiety is also included and almost parallel to the secondary rim of the CD. As indicated by the computed binding affinity, this tight binding mode of R-complex enhances the host–guest hydrophobic interaction and renders the R-complex significantly more stable than the S-complex. In contrast, the binding modes of R- and S-TB with β-CD are similar due to the poor flexibility of the host, which jeopardizes its ability to differentiate R- and S-TB.

利用β-环糊精(β-CD)及其衍生物手性分离特布他林(TB)引起了广泛的关注。本文基于实验数据,采用分子动力学/量子力学/连续溶剂模型(MD/QM/CSM)方法研究了β-CD和庚基(2,3-二- o -乙酰基)-β-CD (HAD-β-CD)对TB的对映分离机理。我们的方法证实了HAD-β-CD/TB两种实验预测的结合模式之一,并将其归因于r复合物。R-TB被HAD-β- CD紧密包含:芳香环在CD腔内,而烷基部分也包含在CD腔内,并且几乎平行于CD的二级边缘。通过计算的结合亲和力表明,r -配合物的这种紧密结合模式增强了主-客体疏水相互作用,使r -配合物比s -配合物更稳定。相比之下,R- tb和S-TB与β-CD的结合方式相似,这是由于宿主的灵活性较差,危及其区分R- tb和S-TB的能力。
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引用次数: 4
Photolytical reactions for light induced biological effectors release: on the road to the phototherapeutic window 光解反应为光诱导生物效应物释放:在通往光疗窗口的路上
IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2021-04-28 DOI: 10.1007/s10847-021-01071-9
C. Morville, J. Chaud, F. Bolze, A. Specht

The use of caged compounds, defined as photolabile precursors of biological effectors, have proven to be attractive in various fields of biology. Photolytical reactions have been widely used to allow a rapid and efficient concentration jump of various biological effectors within organized biological systems. During the last two decades, the challenge was to overcome the difficulty that only high energy UV light was used to induce photochemical reactions on photoremovable protecting groups (PPGs). Infrared-sensitive PPGs should be able to improve in vivo applications of caged compounds. The present review is focused on recent strategies enabling the use of excitation wavelength inside the photo-therapeutical window (600–1000 nm) to efficiently and specifically cleave a chemical bond.

笼状化合物被定义为生物效应物的光敏前体,已被证明在生物学的各个领域具有吸引力。光解反应被广泛应用于有组织的生物系统中各种生物效应物的快速和有效的浓度跳跃。在过去的二十年中,挑战在于克服仅使用高能量紫外线诱导光可去除保护基团(PPGs)上的光化学反应的困难。红外敏感PPGs应该能够改善笼化化合物的体内应用。本文综述了利用光疗窗口内(600-1000 nm)激发波长高效、特异性地切割化学键的最新策略。
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引用次数: 3
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Journal of Inclusion Phenomena and Macrocyclic Chemistry
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