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[Co(DTPA)]3− complex in gelatin gel as a highly sensitive shifting NMR/MRI temperature probe [Co(DTPA)]3−配合物在明胶凝胶中作为高灵敏度位移NMR/MRI温度探针
IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-06-15 DOI: 10.1007/s10847-022-01151-4
S. P. Babailov

The temperature sensitivity of paramagnetic chemical shifts in 1H NMR spectra for the [Co(DTPA)]3− complex in 10% gelatin gel (as a model substrate of human or animal tissues) was studied in detail. The maximum temperature sensitivity of the chemical shifts d(δexp)/dT studied in the gelatin gel of the complex was found to be 0.73 ppm/K (which is about 7% higher than in the previously studied D2O solution of the compound). It turned out that the studied complex is characterized by the highest temperature sensitivity of chemical shifts in the NMR spectra among the complexes of paramagnetic d-elements. Moreover, this complex also shows the highest temperature sensitivity of chemical shifts taking into consideration the half-width of the signal itself (|CT|/W = 0.8 K−1). The [Co(DTPA)]3− complex can be considered as a promising compound for the design of temperature-sensitive NMR probes aimed at determining the local temperature in aqueous media and prospective MRI-assisted disease diagnosis.

详细研究了[Co(DTPA)]3−配合物在10%明胶凝胶(作为人体或动物组织的模型底物)中顺磁化学位移的温度敏感性。在明胶凝胶中研究的化学位移d(δexp)/dT的最大温度敏感性为0.73 ppm/K(比之前研究的化合物的D2O溶液高约7%)。结果表明,所研究的配合物在顺磁性d元素配合物中具有最高的核磁共振光谱温度敏感性。此外,考虑到信号本身的半宽度(|CT|/W = 0.8 K−1),该配合物还显示出对化学位移的最高温度灵敏度。[Co(DTPA)]3−配合物可以被认为是设计温度敏感核磁共振探针的一个有前途的化合物,旨在确定水介质中的局部温度和前瞻性mri辅助疾病诊断。
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引用次数: 2
Cooperative systems constructed using crystalline metal complexes of short flexible peptides 利用短柔性肽的结晶金属配合物构建的合作体系
IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-06-08 DOI: 10.1007/s10847-022-01145-2
Ryosuke Miyake

Biological systems display a range of sophisticated functions that cannot be performed by artificial systems, through intricate cooperative structural changes involving multiple functional units. The designability and structural flexibility of peptides are demonstrated by biological systems that display cooperative structural changes; these properties also make them well-suited for the formation of artificial systems that display such changes. The problem with the use of peptide frameworks is that long peptide residues, which are not suitable for gram-scale use, are required for the formation of stable ordered structures. However, if ordered structures containing peptides could be constructed by coordinating them to metal ions, peptides could be widely used to develop sophisticated functional materials. Crystal packing can be used for the design of functional materials made from simple molecules because it provides a way to place the components relative to each other. Although crystalline systems have been reported in which the small size of the cavities has been attributed to the flexibility of the peptide, recently, large systems with giant cavities have been developed with flexible peptides. In this review, we summarize the formation of cooperative multicomponent systems in the crystalline state using metal complexes of simple peptides, along with recent advances in the construction of giant artificial systems using short peptides.

生物系统通过涉及多个功能单元的复杂合作结构变化,显示出一系列人工系统无法完成的复杂功能。多肽的可设计性和结构灵活性是通过生物系统的协同结构变化来证明的;这些特性也使它们非常适合于形成显示这种变化的人工系统。使用肽框架的问题是,长肽残基不适合克级使用,是形成稳定有序结构所必需的。然而,如果能通过与金属离子配位来构建含肽的有序结构,肽将被广泛用于开发复杂的功能材料。晶体填充可以用于设计由简单分子制成的功能材料,因为它提供了一种将组件相互相对放置的方法。虽然晶体系统中已经报道了小尺寸的空腔归因于肽的柔韧性,但最近,具有巨大空腔的大型系统已经用柔性肽开发出来。本文综述了利用简单肽的金属配合物在晶体状态下形成协同多组分体系的研究进展,以及利用短肽构建巨大人工体系的最新进展。
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引用次数: 1
Preparation of dipolar Y(III)-based monoporphyrinate complexes: conventional vs microwave-assisted reaction and theoretical IR study 偶极Y(III)基单卟啉酸盐配合物的制备:常规与微波辅助反应及理论红外研究
IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-06-06 DOI: 10.1007/s10847-022-01148-z
Edison Matamala-Cea, Luciano Becerra-Pino, Walter A. Rabanal-León, Rodrigo Arancibia, Paulina I. Hidalgo, Claudio A. Jiménez, Néstor Novoa

The dissymmetrical and dipolar Y(III) complex 2 and its cationic precursor 1, containing the proligands 5,10,15,20-tetrakis(4-bromophenyl)porphyrin L1 and 1-anisyl-1,3-butanedione L2, were synthesized at fairly high yields, ranging from 40 to 78%, by conventional and microwave-assisted techniques, and were isolated as a microcrystalline compound. The products obtained in each case were characterized by 1H-NMR, mass spectrometry, elemental analysis, Med-IR and Far-IR. The IR information collected shows good agreement with respect to the density functional theory (DFT) calculations carried out, validating the molecular geometry in each case. This innovative one-pot microwave-based method contributes an efficient pathway for obtaining challenging molecular architectures based on monoporphyrinate complexes without Diglyme.

采用常规和微波辅助技术,合成了不对称偶极Y(III)配合物2及其阳离子前体1,其前置配体为5,10,15,20-四(4-溴苯基)卟啉L1和1-茴香基-1,3-丁二酮L2,产率在40% ~ 78%之间,并分离得到微晶化合物。通过1H-NMR、质谱、元素分析、mid - ir和Far-IR对所得产物进行了表征。所收集的红外信息与所进行的密度泛函理论(DFT)计算显示出良好的一致性,验证了每种情况下的分子几何形状。这种创新的一锅微波方法为获得具有挑战性的分子结构提供了一种有效的途径,这种分子结构基于单卟啉酸配合物,不含双lyme。
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引用次数: 0
Ct-DNA binding and antimicrobial studies of MnII and FeII macrocyclic complexes MnII和FeII大环配合物的Ct-DNA结合及抗菌研究
IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-06-03 DOI: 10.1007/s10847-022-01150-5
Anuj Kumar, Vinod Kumar Vashistha, Dipak Kumar Das, Ram K. Gupta, Ghulam Yasin

The designing of efficient macrocyclic complexes for the alteration in nucleic acids and understanding is still in debate. Herein, to study the deoxyribonucleic acid (DNA) interaction with MN5-complexes, two macrocyclic complexes, A (MnII) and B (FeII), have been synthesized and characterized using multiple analytical techniques. The electronic absorption, fluorescence, and electrochemical methods were utilized to examine the binding ability of both complexes with calf thymus-DNA (ct-DNA). The spectral results were found to be in good agreement with the interaction of both complexes with ct-DNA, as also supported by the remarkable decrease in both anodic peak current (ipa) and cathodic peak current (ipc) during cyclic voltammetric analysis in the presence of ct-DNA. The spectral investigations clearly indicated the higher binding affinity of complex A as compared to complex B towards ct-DNA. Additionally, both complexes were also found to be potential antibacterial agents.

如何设计有效的大环配合物来改变核酸及其理解仍存在争议。为了研究脱氧核糖核酸(DNA)与mn5配合物的相互作用,合成了两个大环配合物A (MnII)和B (FeII),并利用多种分析技术对其进行了表征。利用电子吸收、荧光和电化学方法检测这两种复合物与小牛胸腺dna (ct-DNA)的结合能力。在循环伏安分析中发现,在ct-DNA存在下,两种配合物的阳极峰电流(ipa)和阴极峰电流(ipc)显著降低,这也支持了光谱结果与ct-DNA的相互作用。光谱研究清楚地表明配合物A对ct-DNA的结合亲和力高于配合物B。此外,这两种配合物也被发现是潜在的抗菌剂。
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引用次数: 2
Inclusion complex of cyclodextrin with ergotamine and evaluation of cyclodextrin-based nanosponges 环糊精-麦角胺包合物及环糊精基纳米海绵的研究
IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-06-02 DOI: 10.1007/s10847-022-01149-y
Preeti Dali, Pravin Shende

Purpose

The anti-migraine drugs show first-pass metabolism, short half-life, and low bioavailability resulting in repeated dose or overdose effect. Polymeric, biodegradable and highly porous nanosponges emerge as a promising carrier for migraine treatment to improve aqueous solubility, stability and bioavailability.

Method

Ergotamine nanosponges prepared by interfacial polymerization method wherein hydroxypropyl beta-cyclodextrin inclusion complex was crosslinked using toluene diisocyanate. Caffeine used as a permeation enhancer for ergotamine by forming soluble molecular complex with cyclodextrin moiety of nanosponges. Further, nanosponges were characterized for particle size, zeta potential, entrapment efficiency, percentage drug release profile, antioxidant activity, photostability and instrumental analytical studies.

Results

Caffeine significantly improved the permeation of ergotamine nanosponges. The particle size for optimized nanosponges was 693.5 ± 11.7 nm, zeta potential of − 19.4 ± 5.69 mV with high colloidal stability and maximum entrapment efficiency of 98.88 ± 2.8%. In-vitro and ex-vivo studies exhibited controlled release profiles of ergotamine 81.6% ± 3.4% and 79% ± 4.2% for 24 h, respectively. Nanosponges demonstrated higher antioxidant activity 85.68% ± 1.23% whereas photostability data showed no significant decrease in drug content indicating good stability. Fourier transform infrared spectroscopy confirmed significant interaction of ergotamine with cyclodextrin-based nanosponges.

Conclusion

Nanosponges showed improvement in bioavailability of ergotamine and long-term stability offering inexpensive, productive and safe alternative for migraine.

Graphical abstract

目的抗偏头痛药物具有首过代谢、半衰期短、生物利用度低等特点,可导致重复给药或过量用药。聚合物、可生物降解和高多孔纳米海绵作为一种很有前途的偏头痛治疗载体,可以改善水溶性、稳定性和生物利用度。用甲苯二异氰酸酯交联羟丙基-环糊精包合物,采用界面聚合法制备甲氧哥胺纳米海绵。咖啡因与纳米海绵的环糊精部分形成可溶性分子络合物,作为麦角胺的渗透促进剂。此外,对纳米海绵的粒径、zeta电位、包封效率、药物释放百分比、抗氧化活性、光稳定性和仪器分析研究进行了表征。结果支架碱能显著提高麦角胺纳米海绵的通透性。优化后的纳米海绵粒径为693.5±11.7 nm, zeta电位为- 19.4±5.69 mV,胶体稳定性高,最大包封效率为98.88±2.8%。体外和离体研究显示,24 h麦角胺的控释谱分别为81.6%±3.4%和79%±4.2%。纳米海绵具有较高的抗氧化活性(85.68%±1.23%),而光稳定性数据显示,纳米海绵的药物含量没有显著下降,具有良好的稳定性。傅里叶变换红外光谱证实麦角胺与环糊精基纳米海绵有显著的相互作用。结论纳米海绵提高了麦角胺的生物利用度和长期稳定性,是治疗偏头痛的廉价、高效、安全的替代药物。图形抽象
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引用次数: 2
A retrospective-prospective survey of porphyrinoid fluorophores: towards new architectures as an electron transfer systems promoter 卟啉类荧光团的回顾-前瞻性研究:作为电子转移系统促进剂的新结构
IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-05-31 DOI: 10.1007/s10847-022-01147-0
Sajad Khanlarkhani, Ali Reza Akbarzadeh, Rahmatollah Rahimi

Porphyrins are photoactive molecules with an 18 electron π-conjugated system, and exposure to light promotes electrons to higher energy levels. They are currently gaining popularity because of their special applications’ unique optoelectronic properties. They also serve as fluorescent chemosensors for detecting different types of various chemicals. In this review, we will focus on the representative cases of porphyrinoid fluorophores according to the kinetic and mechanism of the electron/energy transfer process, including popular mechanisms like ICT, PET, FRET, PCET, 2PE, etc. This paper was divided into the following sections: the first is mainly about electron transfer (ET) mechanisms in porphyrinoid fluorophores for probing biological systems. The second section discusses the ET processes of hybridized material and quantum dots. Section three is regarding ET to characterize the interaction of porphyrinoids with model proteins. The combination of porphyrin components like dyad/triad and their characterizations was subjected in the fourth section.

卟啉是具有18个电子共轭体系的光活性分子,暴露在光下可以促进电子达到更高的能级。由于其特殊应用的独特光电特性,它们目前越来越受欢迎。它们还可以作为荧光化学传感器来检测不同类型的各种化学物质。本文将根据电子/能量转移过程的动力学和机理,重点介绍一类卟啉类荧光团的典型案例,包括ICT、PET、FRET、PCET、2PE等常见的转移机制。本文分为以下几个部分:第一部分主要研究探测生物系统的类卟啉荧光团中的电子转移(ET)机制。第二部分讨论了杂化材料和量子点的ET过程。第三部分是关于ET表征卟啉类物质与模型蛋白的相互作用。第四节讨论了卟啉二联体/三联体等卟啉组分的组合及其表征。
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引用次数: 1
The role of water molecular structuring in the formation of the inclusion compounds based on cucurbit[8]uril and trans-[Co(en)2Cl2]+, trans-[Ru(en)2Cl2]+ complexes: a DFT examination 水分子结构在瓜[8]脲基化合物和反式-[Co(en)2Cl2]+、反式-[Ru(en)2Cl2]+配合物形成中的作用:DFT检验
IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-05-30 DOI: 10.1007/s10847-022-01146-1
Tatiana N. Grishaeva, Alexey N. Masliy, Andrey M. Kuznetsov

This paper presents the results of studying the structural features of inclusion compounds based on the cucurbit[8]uril macrocycle and the cobalt(III) and ruthenium(III) complexes (trans-[Co(en)2Cl2]+ and trans-[Ru(en)2Cl2]+) within the framework of the density functional theory taking into account the course of the reaction in the aqueous solution. Formation thermodynamics of the complexes in the cavitands was evaluated by taking into account the most probable number of water molecules inside cucurbit[8]uril. In this methodology, the complexation was considered as a substitution reaction in which the guest complex displaces partially or completely the water molecules that are located inside the cavity. The water molecules present in the cavitand were shown to play an important role in the fixation of the guest complex inside the cavity due to the hydrogen bonds with the oxygen portals. The role of water molecules in the fixation of the complex in the cavity of the macrocycle with the formation of a particular structure is shown. The symmetrical arrangement of the fixing water molecules in the portals leads to a more symmetric arrangement of the metal complex in the cucurbit[8]uril cavity, while their asymmetric localization leads to a significant turn of the complex. Comparison of the main geometric characteristics according to the calculation and X-ray structural analysis showed good agreement. The thermodynamic parameters of the formation of the inclusion compound are estimated. It is shown that the energy contribution of macrocycle deformation to the energetics of formation of the inclusion compound is insignificant.

本文在密度泛函理论的框架下,结合水溶液反应过程,研究了基于葫芦[8]脲大环和钴(III)、钌(III)配合物(反式-[Co(en)2Cl2]+和反式-[Ru(en)2Cl2]+)的包合物的结构特征。通过考虑葫芦[8]中最可能的水分子数来评估空腔中配合物的形成热力学。在这种方法中,络合被认为是一种取代反应,其中客体络合物部分或完全取代了位于腔内的水分子。由于与氧入口的氢键,存在于腔中的水分子在腔内客体复合物的固定中起着重要作用。表明了水分子在大环腔内络合物的固定和形成特定结构中的作用。固定的水分子在孔洞中的对称排列导致金属配合物在瓜[8]孔洞中的排列更加对称,而它们的不对称定位导致配合物的明显转向。计算结果与x射线结构分析结果吻合较好。估计了包合物形成的热力学参数。结果表明,大循环变形对包合物形成的能量贡献不显著。
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引用次数: 1
Molecular insights into the complex formation between dodecamethylcucurbit[6]uril and phenylenediamine isomers 十二甲基葫芦[6]脲和苯二胺异构体之间复合物形成的分子见解
IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-05-29 DOI: 10.1007/s10847-022-01144-3
Venkataramanan Natarajan Sathiyamoorthy, Ambigapathy Suvitha, Ryoji Sahara

The complexation behavior of diprotonated phenylenediamine isomers with decamethylene cucurbit[6]uril (Me12Q[6]) in 1:1 and 1:2 stoichiometry was investigated in vacuum and solution using density functional theory (DFT). Among the isomers, o-phenylenediamine (oPDA) forms an exclusion complex in 1:1 stoichiometry, while others form an inclusion complex. In the 1:2 stoichiometry, at least one of the guest molecule lie on the surface of the Me12Q[6] cavity. The structural reorganization was found to depend on the mode of interaction of the guest molecule. In the gas phase, the enthalpy and Gibbs free energy are negative for all the complexes demonstrating the encapsulation process is spontaneous and thermodynamically favorable. In the solution phase, the enthalpy and entropy are negative for complexes with guest molecules meta- and para-isomers of phenylenediamine. For oPDA as a guest, the enthalpy and entropy are positive indicating the complex formation to be nonspontaneous. The MESP isosurface of complexes shows a higher accumulation of charge in the 1:2 stoichiometry, which reduces their stability. AIM analysis shows the interaction between oPDA and Me12Q[6] is due to hydrogen bonding with moderate strength, while for the other isomers, interactions between the benzene group and the Me12Q[6] cavity were noticed. EDA analysis shows the larger contribution is the electrostatic attraction and it decreases with the increase in the guest ratio. The formation of inclusion complexes by mPDA and pPDA and the surface adsorption of oPDA on Me12Q[6] and the higher accumulation of positive charge during solvation in oPDA@Me12Q[6] complexes make them labile in the solution phase.

Graphical abstract

利用密度泛函理论(DFT)研究了双质子化苯二胺同分异构体与十亚甲基葫芦[6]脲(Me12Q[6])在1:1和1:2的化学计量中与真空和溶液中的络合行为。在同分异构体中,邻苯二胺(oPDA)以1:1的化学计量形成排斥络合物,而其他异构体形成包合络合物。在1:2的化学计量中,至少有一个客体分子位于Me12Q[6]腔的表面。发现结构重组依赖于客体分子的相互作用模式。在气相中,所有配合物的焓和吉布斯自由能均为负,表明包封过程是自发的,热力学有利。在溶液中,与客体分子的苯二胺的间异构体和对异构体的配合物的焓和熵为负。当oPDA为客体时,焓和熵均为正,表明络合物的形成是非自发的。配合物的MESP等值面在1:2的化学计量中表现出较高的电荷积累,这降低了配合物的稳定性。AIM分析表明,oPDA与Me12Q[6]之间的相互作用是由中等强度的氢键形成的,而其他同分异构体则是苯基与Me12Q[6]空腔之间的相互作用。EDA分析表明,静电吸引力的贡献较大,随着客体比的增加而减小。mPDA和pPDA形成的包合物以及oPDA在Me12Q上的表面吸附[6]以及oPDA@Me12Q[6]配合物溶剂化过程中较高的正电荷积累使其在溶液中不稳定。图形抽象
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引用次数: 1
Cyclodextrin-based catenanes and polycatenanes 基于环糊精的连环烷和聚连环烷
IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-05-06 DOI: 10.1007/s10847-022-01143-4
Taishi Higashi, Keiichi Motoyama, Jun Li

In recent years, a number of interlocked molecules such as rotaxanes, catenanes, polyrotaxanes, and polycatenanes have been actively synthesized. Cyclodextrins (CDs) are representative building blocks of these interlocked molecules; however, very few reports are available on CD-based catenanes and polycatenanes. In this review article, we provide an overview of CD-based interlocked molecules and introduce examples of CD-based catenanes and polycatenanes. Finally, the perspectives of research on CD-based catenanes and polycatenanes are discussed.

近年来,许多互锁分子如轮烷、连环烷、聚轮烷、聚连环烷等被积极合成。环糊精(CDs)是这些互锁分子的代表性组成部分;然而,关于基于cd的链烷和聚链烷的报道很少。本文综述了基于cd的连锁分子,并介绍了基于cd的链烷和聚链烷的例子。最后,对基于cd的链烷和聚链烷的研究前景进行了展望。
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引用次数: 2
The bisbenzothiazole-p-tert-butylcalix[4]arene-thiourea Langmuir–Blodgett thin films: preparation, optical properties, swelling dynamics and gas sensing properties via host–guest principles 双苯并噻唑-对叔丁基杯[4]芳烃-硫脲Langmuir-Blodgett薄膜:主客体原理制备、光学性能、膨胀动力学和气敏性能
IF 2.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Pub Date : 2022-05-04 DOI: 10.1007/s10847-022-01142-5
S. Bozkurt, M. Durmaz, M. Erdogan, C. Ozkaya Erdogan, R. Capan, Y. Acikbas

Calix[4]arene-based materials have been investigated to develop selective, sensitive, and low cost chemical sensors due to their simple, low cost synthesis, and wide range of chemical and physical properties. In this study, bisbenzothiazole-p-tert-butylcalix[4]arene-thiourea (BBTC[4]T) molecules were employed to produce thin films via Langmuir–Blodgett (LB) thin film fabrication technique. The optical properties and gas sensing abilities of these BBTC[4]T LB films were examined by Surface Plasmon Resonance (SPR) method. In order to illuminate the optical properties of calix[4]arene-based LB films the Winspall software was utilized by fitting the experimental data obtained from SPR device. The values of 1.23 ± 0.07 nm and 1.53 ± 0.05 were determined for the thickness per monolayer and the refractive index of BBTC[4]T-based LB films, respectively. The fabricated optical sensor was employed for its sensing abilities against to organic vapours (acetone, ethyl alcohol, methyl alcohol and isopropyl alcohol) via the mechanism of host–guest interaction. The current study also describes the diffusion coefficients of these organic vapours to illuminate the swelling dynamics’ BBTC[4]T-based LB thin films by performing the early-time Fick’s diffusion equation. The responses of calix[4]arene-based optical sensor in terms of the shift in reflective intensity and the values of diffusion coefficients showed that BBTC[4]T molecules can be developed as potential chemical sensor element for acetone vapour compared to alcohol vapours.

杯[4]芳烃基材料由于其简单、低成本的合成和广泛的化学和物理性质,已被研究用于开发选择性、敏感性和低成本的化学传感器。本研究采用Langmuir-Blodgett (LB)薄膜制备技术,采用双苯并噻唑-对叔丁基杯[4]芳烯-硫脲(BBTC[4]T)分子制备薄膜。采用表面等离子体共振(SPR)方法检测了这些BBTC[4]T LB薄膜的光学性能和气敏性能。为了阐明杯[4]芳烃基LB薄膜的光学性质,利用Winspall软件对SPR装置获得的实验数据进行拟合。测定了BBTC[4]基LB膜的单层厚度和折射率分别为1.23±0.07 nm和1.53±0.05。所制备的光学传感器通过主客体相互作用机制对丙酮、乙醇、甲醇和异丙醇等有机气体具有传感能力。本研究还描述了这些有机蒸汽的扩散系数,通过执行早期菲克扩散方程来阐明基于BBTC[4]的LB薄膜的膨胀动力学。基于杯[4]芳烃的光学传感器在反射强度位移和扩散系数值方面的响应表明,与酒精蒸汽相比,BBTC[4]T分子可以作为丙酮蒸汽的潜在化学传感器元件。
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引用次数: 0
期刊
Journal of Inclusion Phenomena and Macrocyclic Chemistry
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