Pub Date : 2023-09-28DOI: 10.1007/s12210-023-01197-7
Mohamed M. Shawky Abou Leila, Wadia Albarqawi
{"title":"Correction to: The adopted urban and heritage preservation methodologies in the Arab world: a review article","authors":"Mohamed M. Shawky Abou Leila, Wadia Albarqawi","doi":"10.1007/s12210-023-01197-7","DOIUrl":"https://doi.org/10.1007/s12210-023-01197-7","url":null,"abstract":"","PeriodicalId":54501,"journal":{"name":"Rendiconti Lincei-Scienze Fisiche E Naturali","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135386532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-27DOI: 10.1007/s12210-023-01193-x
Alessandro Bemporad, Silvano Fineschi, Lucia Abbo, Carlo Benna, Ruggero Biondo, Gerardo Capobianco, Francesco Carella, Alberto Cora, Federica Frassati, Silvio Giordano, Hervé Haudemand, Federico Landini, Davide Loreggia, Salvatore Mancuso, Andrea Mignone, Gianalfredo Nicolini, Maurizio Pancrazzi, Francesco Salvati, Roberto Susino, Daniele Telloni, Luca Zangrilli
Abstract The Solar Physics Group at the INAF-Turin Astrophysical Observatory (OATo) is actually involved in different Space Weather (SW) projects and missions. In particular, this Group is currently providing for the ESA SWESNET portal two new data analysis tools aimed at (1) the automated identification of magnetic flux ropes from the in situ data (CME magnetic effectiveness tool) and (2) the automated identification and arrival prediction of CMEs from remote sensing and in situ data (CME propagation and forecast tool). The Group is also developing numerical tools for future applications of interest for SW under the project SWELTO-Space WEather Laboratory in Turin Observatory. Moreover, the Group is participating in two SW missions, and in particular in Helianthus (research and development project on solar photonic propulsion for early SW warnings) and Selene (Solar Exploration by Lunar Eclipsing with Nanosatellites Experiment). In addition to this, the Group is leading or is involved in other “SW enabling science” projects, and in particular the Metis coronagraph on-board ESA Solar Orbiter mission, the ASPIICS coronagraph on-board ESA PROBA-3 mission, and the CorMag coronagraph on-board HEMERA stratospheric balloon. In this framework, the OATo Solar Physics Group is working on fundamental research on “SW enabling science”, dealing with the origin and acceleration of solar wind and Coronal Mass Ejections with remote-sensing data, and their interplanetary propagation and evolution with in situ data.
{"title":"Space weather-related activities and projects on-going at INAF-Turin Observatory","authors":"Alessandro Bemporad, Silvano Fineschi, Lucia Abbo, Carlo Benna, Ruggero Biondo, Gerardo Capobianco, Francesco Carella, Alberto Cora, Federica Frassati, Silvio Giordano, Hervé Haudemand, Federico Landini, Davide Loreggia, Salvatore Mancuso, Andrea Mignone, Gianalfredo Nicolini, Maurizio Pancrazzi, Francesco Salvati, Roberto Susino, Daniele Telloni, Luca Zangrilli","doi":"10.1007/s12210-023-01193-x","DOIUrl":"https://doi.org/10.1007/s12210-023-01193-x","url":null,"abstract":"Abstract The Solar Physics Group at the INAF-Turin Astrophysical Observatory (OATo) is actually involved in different Space Weather (SW) projects and missions. In particular, this Group is currently providing for the ESA SWESNET portal two new data analysis tools aimed at (1) the automated identification of magnetic flux ropes from the in situ data (CME magnetic effectiveness tool) and (2) the automated identification and arrival prediction of CMEs from remote sensing and in situ data (CME propagation and forecast tool). The Group is also developing numerical tools for future applications of interest for SW under the project SWELTO-Space WEather Laboratory in Turin Observatory. Moreover, the Group is participating in two SW missions, and in particular in Helianthus (research and development project on solar photonic propulsion for early SW warnings) and Selene (Solar Exploration by Lunar Eclipsing with Nanosatellites Experiment). In addition to this, the Group is leading or is involved in other “SW enabling science” projects, and in particular the Metis coronagraph on-board ESA Solar Orbiter mission, the ASPIICS coronagraph on-board ESA PROBA-3 mission, and the CorMag coronagraph on-board HEMERA stratospheric balloon. In this framework, the OATo Solar Physics Group is working on fundamental research on “SW enabling science”, dealing with the origin and acceleration of solar wind and Coronal Mass Ejections with remote-sensing data, and their interplanetary propagation and evolution with in situ data.","PeriodicalId":54501,"journal":{"name":"Rendiconti Lincei-Scienze Fisiche E Naturali","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135537918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-20DOI: 10.1007/s12210-023-01192-y
Shivani Yadav, Sunil Kumar, Anil Kumar Haritash
Chlorophenols are the persistent organic contaminants released in the aquatic bodies by industrial manufacturing units. Treatment of phenolic wastewater is an arduous process for conventional treatment methods because of their high stability and complexity. The present study deals with degradation of 2,4,6-Trichlorophenol, using Photo-Fenton’s process. The study commences the optimisation and validation of different regulating parameters like pH, oxidant (H2O2), and Fe2+ ions at variable concentration in batch mode. At pH 3.0, Fe2+ 0.5 mM, and H2O2 (10.0 mM), complete degradation of trichlorophenol was observed within 6 min of reaction time. The mineralisation of the model pollutant was studied over TOC analyser and HPLC. Response Surface Plots were drawn to define the interactive relationship between process governing Fenton’s process. Under optimized conditions, different Fenton-integrated processes, such as Solar-Fenton, Sono-Fenton, and Sono-Photo-Fenton (UV365), were compared for degradation of TCP. Among all the processes, Solar-Fenton resulted in rapid and complete degradation of TCP within 5 min. The mineralisation efficiency of Fenton’s process, Solar-Fenton, Sono-Fenton, Sono-Photo-Fenton, and Photo-Fenton’s processes were 50%, 98%, 90%, 75%, and 50%, respectively. The results indicated Solar-assisted Fenton as potential and efficient approach toward degradation of Trichlorophenol.
{"title":"Solar light and ultrasound-assisted rapid Fenton’s oxidation of 2,4,6-trichlorophenol: comparison, optimisation, and mineralisation","authors":"Shivani Yadav, Sunil Kumar, Anil Kumar Haritash","doi":"10.1007/s12210-023-01192-y","DOIUrl":"https://doi.org/10.1007/s12210-023-01192-y","url":null,"abstract":"Chlorophenols are the persistent organic contaminants released in the aquatic bodies by industrial manufacturing units. Treatment of phenolic wastewater is an arduous process for conventional treatment methods because of their high stability and complexity. The present study deals with degradation of 2,4,6-Trichlorophenol, using Photo-Fenton’s process. The study commences the optimisation and validation of different regulating parameters like pH, oxidant (H2O2), and Fe2+ ions at variable concentration in batch mode. At pH 3.0, Fe2+ 0.5 mM, and H2O2 (10.0 mM), complete degradation of trichlorophenol was observed within 6 min of reaction time. The mineralisation of the model pollutant was studied over TOC analyser and HPLC. Response Surface Plots were drawn to define the interactive relationship between process governing Fenton’s process. Under optimized conditions, different Fenton-integrated processes, such as Solar-Fenton, Sono-Fenton, and Sono-Photo-Fenton (UV365), were compared for degradation of TCP. Among all the processes, Solar-Fenton resulted in rapid and complete degradation of TCP within 5 min. The mineralisation efficiency of Fenton’s process, Solar-Fenton, Sono-Fenton, Sono-Photo-Fenton, and Photo-Fenton’s processes were 50%, 98%, 90%, 75%, and 50%, respectively. The results indicated Solar-assisted Fenton as potential and efficient approach toward degradation of Trichlorophenol.","PeriodicalId":54501,"journal":{"name":"Rendiconti Lincei-Scienze Fisiche E Naturali","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136308880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-13DOI: 10.1007/s12210-023-01191-z
Mustafa Kıralan, Hakkı Fırat Çakıcı, İsra Toptancı, Mohamed Fawzy Ramadan
Flavored olive oils were generally produced with the maceration method, which has disadvantages such as taking a long time and making the tanks unusable for a long time. The new techniques could produce flavored oils to shorten time according to maceration. In this work, three different olive oil types, including extra-virgin olive oil (EVOO), refined olive oil (RO), and refined olive pomace oil (RPO) as oil sources and five plant materials (Tulsi, Thyme, Marjoram, Rosemary and Oregano) as flavoring materials were selected and subjected to a heating process in a microwave oven for a duration of 6, 8, 10, and 15 min at a constant frequency of 2450 MHz and a power of 0.45 kW to produce flavored oils and also used maceration technique. The presence of 4 PAH components, such as benzo(a)pyrene (B[a]P), benzo[a]anthracene (B[a]A), benzo(b)fluoranthene (B[b]F), and Chrysen (Chr), classified as dangerous for health was measured in the oils that were macerated and microwaved. In macerated oils, only B[a]P was detected in flavored RPOs. However, B[a]P and Chr were detected in all flavored oils, especially in a long-time microwave (10 and 15 min). Besides, B[a]A and B[b]F were found in only flavored RPOs with an increase in exposure time (10 and 15 min). The concentration of B[a]P detected in four samples, including the control sample (CRPO) and flavored samples, was above the limit value of 2 µg/kg. On the other hand, the total content of the four PAHs: B[a]P, B[a]A, B[b]F and Chr did not exceed the limit value of 10 μg/kg. As a result, PAHs are higher in extended exposure to microwave applications in flavored olive oils, compared to the conventional maceration method, resulting in lower-quality products regarding food safety.
{"title":"Measurement of polycyclic aromatic hydrocarbons in aroma-flavored olive oils produced using microwave and traditional maceration methods","authors":"Mustafa Kıralan, Hakkı Fırat Çakıcı, İsra Toptancı, Mohamed Fawzy Ramadan","doi":"10.1007/s12210-023-01191-z","DOIUrl":"https://doi.org/10.1007/s12210-023-01191-z","url":null,"abstract":"Flavored olive oils were generally produced with the maceration method, which has disadvantages such as taking a long time and making the tanks unusable for a long time. The new techniques could produce flavored oils to shorten time according to maceration. In this work, three different olive oil types, including extra-virgin olive oil (EVOO), refined olive oil (RO), and refined olive pomace oil (RPO) as oil sources and five plant materials (Tulsi, Thyme, Marjoram, Rosemary and Oregano) as flavoring materials were selected and subjected to a heating process in a microwave oven for a duration of 6, 8, 10, and 15 min at a constant frequency of 2450 MHz and a power of 0.45 kW to produce flavored oils and also used maceration technique. The presence of 4 PAH components, such as benzo(a)pyrene (B[a]P), benzo[a]anthracene (B[a]A), benzo(b)fluoranthene (B[b]F), and Chrysen (Chr), classified as dangerous for health was measured in the oils that were macerated and microwaved. In macerated oils, only B[a]P was detected in flavored RPOs. However, B[a]P and Chr were detected in all flavored oils, especially in a long-time microwave (10 and 15 min). Besides, B[a]A and B[b]F were found in only flavored RPOs with an increase in exposure time (10 and 15 min). The concentration of B[a]P detected in four samples, including the control sample (CRPO) and flavored samples, was above the limit value of 2 µg/kg. On the other hand, the total content of the four PAHs: B[a]P, B[a]A, B[b]F and Chr did not exceed the limit value of 10 μg/kg. As a result, PAHs are higher in extended exposure to microwave applications in flavored olive oils, compared to the conventional maceration method, resulting in lower-quality products regarding food safety.","PeriodicalId":54501,"journal":{"name":"Rendiconti Lincei-Scienze Fisiche E Naturali","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135733877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-13DOI: 10.1007/s12210-023-01185-x
Matteo Cantoresi, Francesco Berrilli, Fabio Lepreti
Abstract To investigate the statistical properties of the photospheric magnetic fields underlying coronal holes (CHs) and “normal” coronal regions a classical technique, the signed measure, is used. This technique allows to characterize the scaling behavior and the topology of sign-oscillating magnetic structures in selected regions of line of sigth (LoS) magnetograms recorded by the Heliosismic Magnetic Imager on board of the Solar Dynamic Observatory (SDO/HMI). To this end we have compared the properties of the photospheric magnetic field underlying 60 CHs and 60 non-coronal holes (NCHs). In particular, in addition to having studied distributions and momenta of photospheric magnetic fields associated to the selected regions, we have performed the sign singularity analysis computing the cancellation functions of the highly fluctuating photospheric magnetic fields. We have found that photospheric magnetic fields associated to CHs are imbalanced in the sign and that this imbalance emerges mainly at the supergranular scales.
{"title":"Organization scale of photospheric magnetic imbalance in coronal holes","authors":"Matteo Cantoresi, Francesco Berrilli, Fabio Lepreti","doi":"10.1007/s12210-023-01185-x","DOIUrl":"https://doi.org/10.1007/s12210-023-01185-x","url":null,"abstract":"Abstract To investigate the statistical properties of the photospheric magnetic fields underlying coronal holes (CHs) and “normal” coronal regions a classical technique, the signed measure, is used. This technique allows to characterize the scaling behavior and the topology of sign-oscillating magnetic structures in selected regions of line of sigth (LoS) magnetograms recorded by the Heliosismic Magnetic Imager on board of the Solar Dynamic Observatory (SDO/HMI). To this end we have compared the properties of the photospheric magnetic field underlying 60 CHs and 60 non-coronal holes (NCHs). In particular, in addition to having studied distributions and momenta of photospheric magnetic fields associated to the selected regions, we have performed the sign singularity analysis computing the cancellation functions of the highly fluctuating photospheric magnetic fields. We have found that photospheric magnetic fields associated to CHs are imbalanced in the sign and that this imbalance emerges mainly at the supergranular scales.","PeriodicalId":54501,"journal":{"name":"Rendiconti Lincei-Scienze Fisiche E Naturali","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135740832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Application of HPLC, LC-Q-TOF–MS, UF-HPLC and LC–MS in the comparative analysis of flavonoids and sterols in the Citrus paradise cv. shamber (grapefruit)","authors":"Waseem Ahmed, Rafia Azmat, Abdul Qayyum, Yamin Bibi, Shujaat Ali, Raseed Ahmed, Mohamed Fawzy Ramadan","doi":"10.1007/s12210-023-01188-8","DOIUrl":"https://doi.org/10.1007/s12210-023-01188-8","url":null,"abstract":"","PeriodicalId":54501,"journal":{"name":"Rendiconti Lincei-Scienze Fisiche E Naturali","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136071377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The Tazekka Variscan massif is formed by Meso-Cenozoic cover unconformably overlying the Paleozoic rocks recording polyphase tectonic stages contemporary with the emplacement of the magmatic system such as rhyolitic lavas and microdioritic dyke swarms attributed to the Upper Paleozoic tectonic phases and alkaline basaltic lavas attributed to Plio-Quaternary age. The mesostructural and tectonic analyses associated with paleo stress reconstruction are mainly based on the processing of tectonic measurement of slickensides fault planes with striation pitch determined by inversion of fault-slip data and allowed us to highlight the following tectono-magmatic events: (i) the Visean–Namurian phase is divided into two tectonic episodes. The first episode is characterized by NW–SE trending extension, while the second is marked by a relatively minor subhorizontal σ1 compressive axis oriented NE–SW (σ1–σ2 permutation). This latter episode controls the tectonic dislocation of Paleozoic rocks and the emplacement of a few rhyolitic lava flows along submeridian strike-slip faults; (ii) in the Stephanian–Permian age, the tectonic regime changes to a compressive stress state with a horizontal NE–SW trending σ1 axis and a horizontal NW–SE trending σ3 axis, which is what causes the development of NW–SE and NE–SW to ENE–WSW faults filled with microdioritic dyke swarms; (iii) the Permian–Lower-Middle Triassic period was marked by a compressive regime with a horizontal NNW–SSE to submeridian trending σ1 axis and a horizontal ENE–WSW to subequatorial trending σ3 axis, as well as NNE–SSW, WNW–ESE faults, and submeridian microdioritic tension gashes. The compression changes to WNW–ESE during the Vallesian or Lower Pliocene age. Early-Middle Quaternary is divided into two tectonic episodes with a σ1–σ2 axis permutation. Its axis changes from NNW–SSE associated with the ENE–WSW extension and is characterized by NE–SW faults affecting basaltic lavas. Subequatorial strike-slip faults, submeridian normal faults, and Late-Variscan brittle tectonic structures are mostly filled by basaltic lavas.
{"title":"Tectonic fracturing and paleostress reconstruction in the Tazekka Variscan massif (Morocco): implications for magmatic processes","authors":"Youssef Gharmane, Saïd Hinaje, Samir Amrani, Youness Taybi, Driss Yaagoub, Mohamed El Fartati","doi":"10.1007/s12210-023-01190-0","DOIUrl":"https://doi.org/10.1007/s12210-023-01190-0","url":null,"abstract":"The Tazekka Variscan massif is formed by Meso-Cenozoic cover unconformably overlying the Paleozoic rocks recording polyphase tectonic stages contemporary with the emplacement of the magmatic system such as rhyolitic lavas and microdioritic dyke swarms attributed to the Upper Paleozoic tectonic phases and alkaline basaltic lavas attributed to Plio-Quaternary age. The mesostructural and tectonic analyses associated with paleo stress reconstruction are mainly based on the processing of tectonic measurement of slickensides fault planes with striation pitch determined by inversion of fault-slip data and allowed us to highlight the following tectono-magmatic events: (i) the Visean–Namurian phase is divided into two tectonic episodes. The first episode is characterized by NW–SE trending extension, while the second is marked by a relatively minor subhorizontal σ1 compressive axis oriented NE–SW (σ1–σ2 permutation). This latter episode controls the tectonic dislocation of Paleozoic rocks and the emplacement of a few rhyolitic lava flows along submeridian strike-slip faults; (ii) in the Stephanian–Permian age, the tectonic regime changes to a compressive stress state with a horizontal NE–SW trending σ1 axis and a horizontal NW–SE trending σ3 axis, which is what causes the development of NW–SE and NE–SW to ENE–WSW faults filled with microdioritic dyke swarms; (iii) the Permian–Lower-Middle Triassic period was marked by a compressive regime with a horizontal NNW–SSE to submeridian trending σ1 axis and a horizontal ENE–WSW to subequatorial trending σ3 axis, as well as NNE–SSW, WNW–ESE faults, and submeridian microdioritic tension gashes. The compression changes to WNW–ESE during the Vallesian or Lower Pliocene age. Early-Middle Quaternary is divided into two tectonic episodes with a σ1–σ2 axis permutation. Its axis changes from NNW–SSE associated with the ENE–WSW extension and is characterized by NE–SW faults affecting basaltic lavas. Subequatorial strike-slip faults, submeridian normal faults, and Late-Variscan brittle tectonic structures are mostly filled by basaltic lavas.","PeriodicalId":54501,"journal":{"name":"Rendiconti Lincei-Scienze Fisiche E Naturali","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136192221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-09DOI: 10.1007/s12210-023-01187-9
Fatima S. Alaryani, Ifat Alsharif, Nehad. A. Shaer, Nouf S. Al-Abbas, Khairiah Mubarak Alwutayd, Aishah E. Albalawi, Zuhair M. Mohammedsaleh, Sohad Abdulkaleg Alshareef, Waheeb S. Aggad
The study aimed to develop and analyze a conjugated zinc Nano particle formulation that would enhance its anti-cirrhosis activity by increasing its bioavailability and release. Standard characterization procedures were used to create and analyze zinc nano particles (ZNPs). Drug release and hepatic cirrhosis model testing were conducted on rats utilizing the enhanced formulation. For 30 days, ZnNPs were supplied through oral gavage. For biochemical examination of serum samples, rats were anesthetized and slaughtered after the research. The expression of genes and microRNAs (miRNAs) in liver tissues was studied; together with expression of liver specific genes and inflammatory markers. These findings were also validated by liver tissue histological and immune histochemical (IHC) studies. Measuring techniques demonstrated the practical synthesis and conjugation of ZnNPs. Nanohybrid ZnNPs showed significant anticirrhosis therapeutic activity. ZnNPs' anti-cirrhosis properties decrease TGFR1 and COL3A1 expression, because they enhance the production of miRNAs that protect against cirrhosis. Furthermore, the expression of cancer markers (AFP, p53) was down/up-regulated in ZnNPs treated groups. Similarly, the pro- and anti-inflammatory markers expressions were found normalized in ZnNPs groups compared to untreated groups. These results were further validated by histopathology and IHC analysis, which showed that ZnNPs have anti-fibrotic properties. We finally, conclude that the that we achieve loading capacity of 94%, 36.63%, respectively, in the successful synthesis of ZnNPs. Furthermore, ZnNPs exhibits in vivo hepato-protective activity by down-regulating hepatic cancer markers and upregulating hepatic functional markers which assure the use of ZnNPs for the treatment of liver cirrhosis in future studies.
{"title":"Molecular mechanisms of conjugated zinc nano-particles for nano drug delivery against hepatic cirrhosis in CCl4-induced rats model","authors":"Fatima S. Alaryani, Ifat Alsharif, Nehad. A. Shaer, Nouf S. Al-Abbas, Khairiah Mubarak Alwutayd, Aishah E. Albalawi, Zuhair M. Mohammedsaleh, Sohad Abdulkaleg Alshareef, Waheeb S. Aggad","doi":"10.1007/s12210-023-01187-9","DOIUrl":"https://doi.org/10.1007/s12210-023-01187-9","url":null,"abstract":"The study aimed to develop and analyze a conjugated zinc Nano particle formulation that would enhance its anti-cirrhosis activity by increasing its bioavailability and release. Standard characterization procedures were used to create and analyze zinc nano particles (ZNPs). Drug release and hepatic cirrhosis model testing were conducted on rats utilizing the enhanced formulation. For 30 days, ZnNPs were supplied through oral gavage. For biochemical examination of serum samples, rats were anesthetized and slaughtered after the research. The expression of genes and microRNAs (miRNAs) in liver tissues was studied; together with expression of liver specific genes and inflammatory markers. These findings were also validated by liver tissue histological and immune histochemical (IHC) studies. Measuring techniques demonstrated the practical synthesis and conjugation of ZnNPs. Nanohybrid ZnNPs showed significant anticirrhosis therapeutic activity. ZnNPs' anti-cirrhosis properties decrease TGFR1 and COL3A1 expression, because they enhance the production of miRNAs that protect against cirrhosis. Furthermore, the expression of cancer markers (AFP, p53) was down/up-regulated in ZnNPs treated groups. Similarly, the pro- and anti-inflammatory markers expressions were found normalized in ZnNPs groups compared to untreated groups. These results were further validated by histopathology and IHC analysis, which showed that ZnNPs have anti-fibrotic properties. We finally, conclude that the that we achieve loading capacity of 94%, 36.63%, respectively, in the successful synthesis of ZnNPs. Furthermore, ZnNPs exhibits in vivo hepato-protective activity by down-regulating hepatic cancer markers and upregulating hepatic functional markers which assure the use of ZnNPs for the treatment of liver cirrhosis in future studies.","PeriodicalId":54501,"journal":{"name":"Rendiconti Lincei-Scienze Fisiche E Naturali","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136192586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-26DOI: 10.1007/s12210-023-01189-7
Eman A. Suedan, Walaa Abdelmegied, I. Hassan, R. G. El-Kinany
{"title":"Evaluation of the effect of chemical fertilization and some natural extracts on the production of freesia (Freesia refracta L.) plants: a sustainable approach","authors":"Eman A. Suedan, Walaa Abdelmegied, I. Hassan, R. G. El-Kinany","doi":"10.1007/s12210-023-01189-7","DOIUrl":"https://doi.org/10.1007/s12210-023-01189-7","url":null,"abstract":"","PeriodicalId":54501,"journal":{"name":"Rendiconti Lincei-Scienze Fisiche E Naturali","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83116625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-08DOI: 10.1007/s12210-023-01186-w
T. Woo
{"title":"Feasibility study on nuclear propulsion impact on asteroid for planetary space defense (PSD)","authors":"T. Woo","doi":"10.1007/s12210-023-01186-w","DOIUrl":"https://doi.org/10.1007/s12210-023-01186-w","url":null,"abstract":"","PeriodicalId":54501,"journal":{"name":"Rendiconti Lincei-Scienze Fisiche E Naturali","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83785489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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