Ocular Surface最新文献

英文中文

IL-24 regulates corneal inflammation and fibrosis in fungal keratitis via the caspase-11/gasdermin D pathway IL-24通过caspase-11/gasdermin D途径调节真菌性角膜炎的角膜炎症和纤维化

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface

Pub Date : 2026-01-21 DOI: 10.1016/j.jtos.2026.01.005

Hua Yang , Wenting Liu , Dawei Zhang , Qiang Xu , Jieun Lee , Jintao Sun , Shasha Xue , Xiaoyan Sun , Chengye Che

Background

This study aimed to investigate the role of interleukin-24 (IL-24) in the inflammatory response and repair of corneal damage caused by fungal keratitis (FK).

Methods

Mouse model was infected with Aspergillus fumigatus (A. fumigatus) to induce FK. An in vitro model was established by stimulating THP-1 cells and human corneal epithelial cells (HCECs) with A. fumigatus spores. IL-24 expression was inhibited by small interfering RNA (siRNA). The production and role of IL-24 in FK were evaluated using quantitative reverse transcription polymerase chain reaction (qRT-PCR), Western blot, immunofluorescence, clinical scoring, anterior segment optical coherence tomography (OCT), hematoxylin and eosin (HE) staining, confocal corneal microscopy, and myeloperoxidase (MPO) assays.

Results

IL-24 expression was increased in mouse models of FK, fungal-stimulated THP-1 macrophages, and HCECs compared to controls. Compared to controls, siRNA inhibition of IL-24 reduced the inflammatory response, corneal edema, and neutrophil and macrophage recruitment within the corneal stroma. In A. fumigatus-infected keratitis, IL-24 production was induced by hypoxia-inducible factor-1α (HIF-1α). Tumor necrosis factor-α (TNF-α), IL-6, and IL-10 were inflammatory factors regulated by IL-24, which played a role in pyroptosis via the caspase-11/gasdermin D (GSDMD) pathway. Inhibition of IL-24 attenuated corneal neovascularization and fibrosis during long-term FK in mice.

Conclusions

This study demonstrated the important role of IL-24 in corneal antifungal immunity. In A. fumigatus-infected keratitis, IL-24 might be crucial for the recruitment of inflammatory cells, induction of cellular pyroptosis, and production of inflammatory cytokines. Furthermore, IL-24 is also involved in the development of fibrosis during corneal repair.

本研究旨在探讨白细胞介素-24 （IL-24）在真菌性角膜炎（FK）引起的炎症反应和角膜损伤修复中的作用。方法用烟曲霉（Aspergillus fumigatus， A. fumigatus）感染小鼠模型诱导FK。采用烟芽孢杆菌孢子刺激THP-1细胞和人角膜上皮细胞（HCECs）建立体外模型。小干扰RNA （siRNA）抑制IL-24的表达。通过定量逆转录聚合酶链反应（qRT-PCR）、Western blot、免疫荧光、临床评分、前段光学相干断层扫描（OCT）、苏木精和伊红（HE）染色、共聚焦角膜显微镜和髓过氧化物酶（MPO）检测来评估IL-24在FK中的产生和作用。结果与对照组相比，小鼠FK、真菌刺激的THP-1巨噬细胞和HCECs模型中sil -24的表达升高。与对照组相比，siRNA抑制IL-24可减少炎症反应、角膜水肿以及角膜基质内中性粒细胞和巨噬细胞的募集。在烟曲霉感染的角膜炎中，缺氧诱导因子-1α (HIF-1α)诱导IL-24的产生。肿瘤坏死因子-α (TNF-α)、IL-6、IL-10是受IL-24调控的炎症因子，通过caspase-11/gasdermin D （GSDMD）途径参与凋亡。抑制IL-24可减轻小鼠长期FK期间角膜新生血管和纤维化。结论IL-24在角膜抗真菌免疫中起重要作用。在烟曲霉感染的角膜炎中，IL-24可能对炎症细胞的募集、细胞热亡的诱导和炎症细胞因子的产生至关重要。此外，IL-24还参与角膜修复过程中纤维化的发生。

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引用次数: 0

Serum inflammatory biomarkers in ocular pemphigoid closely resemble that of dry eye disease: A cross-sectional study 眼类天疱疮的血清炎症生物标志物与干眼病非常相似：一项横断面研究

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface

Pub Date : 2026-01-20 DOI: 10.1016/j.jtos.2026.01.004

Yulu Wang , Adrian P. Mansini , Jing Li , Haley Gainer , Claudia Lasalle , Sanjana Chandran , Sumaiya Shahjahan , Hajirah N. Saeed , Ali Djalilian , Kyle T. Amber

引用次数: 0

Video frame rate influences the accuracy of blink dynamics measurement 视频帧率影响闪烁动态测量的准确性

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface

Pub Date : 2026-01-19 DOI: 10.1016/j.jtos.2026.01.003

Maria Navascues-Cornago, Carole Maldonado-Codina, Philip B. Morgan, Michael L. Read

Purpose

High-speed imaging is required to capture the rapid eyelid motion during blinking. However, the minimum frame rate necessary for accurate measurement remains unclear. This study investigated how video frame rate affects the accuracy of blink metrics.

Methods

Spontaneous blinks were recorded in 20 participants and reflex blinks were recorded in an additional 10 participants using a 500 frames per second (fps) high-speed infrared camera. Videos were downsampled to simulate acquisition at 250, 100, 50 and 25 fps. Blink metrics were extracted at each frame rate: average and maximum closing/opening velocities, closed-phase duration, total duration, and amplitude. Percentage differences from the 500-fps reference were calculated and agreement was assessed using Bland-Altman analysis with limits of agreement (LoA).

Results

Agreement with the 500-fps reference varied across metrics. Blink amplitude and duration showed minimal bias and narrow LoA across all frame rates. In contrast, velocity metrics were underestimated at low frame rates, particularly for maximum velocities and reflex blinks. For spontaneous blinks, average closing velocity showed good agreement at 100–250 fps, whereas for reflex blinks, only 250 fps achieved comparable measurements. Average opening velocity was less sensitive to frame rate, with ≥50 fps showing minimal bias. Maximum velocities were markedly underestimated below 250 fps for both blink types.

Conclusion

Video frame rate significantly impacts the accuracy of certain blink metrics. Low frame rates may be sufficient for estimating blink amplitude and duration, while velocity metrics require higher sampling. A minimum of 250 fps is recommended for a comprehensive assessment of blink dynamics.

目的采用高速成像技术捕捉眨眼过程中眼睑的快速运动。然而，精确测量所需的最小帧率仍然不清楚。本研究探讨了视频帧率如何影响眨眼指标的准确性。方法采用500帧/秒高速红外摄像机，对20名受试者的自发眨眼和10名受试者的反射眨眼进行记录。视频被下采样以模拟250、100、50和25 fps的采集。在每个帧速率下提取眨眼指标：平均和最大关闭/打开速度，关闭相位持续时间，总持续时间和幅度。计算与500帧/秒参考数据的百分比差异，并使用具有一致性限制（LoA）的Bland-Altman分析评估一致性。结果：与500帧/秒参考的一致性因指标而异。闪烁幅度和持续时间在所有帧速率下显示最小偏差和窄LoA。相比之下，在低帧率下，速度指标被低估了，特别是对于最大速度和反射眨眼。对于自发眨眼，平均闭合速度在100-250 fps之间表现出良好的一致性，而对于反射眨眼，只有250 fps达到可比的测量值。平均打开速度对帧速率不太敏感，≥50 fps显示最小偏差。两种闪烁类型的最大速度在250 fps以下都被明显低估了。结论视频帧率显著影响某些眨眼指标的准确性。低帧率可能足以估计眨眼幅度和持续时间，而速度指标需要更高的采样。要全面评估眨眼动态，建议至少250帧/秒。

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引用次数: 0

Paediatric Acanthamoeba keratitis: Risk factors, clinical features and treatment outcomes 儿童棘阿米巴角膜炎：危险因素、临床特征和治疗结果

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface

Pub Date : 2026-01-10 DOI: 10.1016/j.jtos.2026.01.002

A.L. Milligan , C.B.J. Ashton , A.C. Randag , D.F.P. Larkin

引用次数: 0

Cattle to Cornea: A series of C. bovis eye cultures 牛角膜：一系列牛眼培养

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface

Pub Date : 2026-01-09 DOI: 10.1016/j.jtos.2026.01.001

Carla G. Dias , Tobin B.T. Thuma , Jamie Marino , Matthew S. Simon , Grace Sun

引用次数: 0

Pipeline: Pharmacotherapy of dry eye disease in vertebrates 管道：脊椎动物干眼病的药物治疗

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface

Pub Date : 2026-01-01 DOI: 10.1016/j.jtos.2025.10.005

Gary D. Novack , Sara M. Thomasy , Brian Leonard

引用次数: 0

In vivo calcium imaging of corneal sensory nerves with fluorescent stereoscopic microscopy 用荧光立体显微镜观察角膜感觉神经的体内钙显像

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface

Pub Date : 2026-01-01 DOI: 10.1016/j.jtos.2025.10.001

George E. Hoekel , Changxiong J. Guo , Timileyin Olugbenro , Qin Liu , Andrew J.W. Huang

引用次数: 0

Letter to the editor regarding “Prospective consecutive case series of patients with neurotrophic keratopathy associated with unilateral total limbal stem cell deficiency caused by severe ocular surface burns” 致编辑关于“严重眼表烧伤引起的单侧全角膜干细胞缺乏症神经营养性角膜病变患者的前瞻性连续病例系列”的信

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface

Pub Date : 2026-01-01 DOI: 10.1016/j.jtos.2025.11.004

Mehmet Gurdal , Ozlem Barut Selver

引用次数: 0

Letter to Editor: Prospective consecutive case series of patients with neurotrophic keratopathy associated with unilateral total limbal stem cell deficiency caused by severe ocular surface burns 致编者信：对严重眼表烧伤引起的伴有单侧全角膜缘干细胞缺乏症的神经营养性角膜病变患者进行前瞻性连续病例研究

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface

Pub Date : 2026-01-01 DOI: 10.1016/j.jtos.2025.11.003

Francisco Figueiredo

引用次数: 0

Prevalence of novel Sjögren's antibodies in a multi-center cohort of dry eye patients 新型Sjögren抗体在干眼症患者多中心队列中的流行

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface

Pub Date : 2026-01-01 DOI: 10.1016/j.jtos.2025.12.001

David Hsu , Yinxi Yu , Esen K. Akpek , Lee W. Guo , Tiffany Liu , Mina Massaro-Giordano , Soo Abboud , Franz Fogt , Devica Bhutani , Emma Iacobucci , Jay Pendyala , Frederick B. Vivino , Alan N. Baer , Gui-shuang Ying , Vatinee Y. Bunya

Purpose

To assess the prevalence of novel Sjögren's disease (SjD) autoantibodies in dry eye disease (DED) patients with or without SjD.

Participants

DED patients were recruited from two tertiary care clinics and categorized by SjD status per the 2016 American College of Rheumatology and European Alliance of Associations for Rheumatology criteria.

Methods

Participants underwent a battery of DED evaluations (unanesthetized Schirmer's test, tear film break up time, corneal and conjunctival vital dye staining), and unstimulated salivary flow rate assessment. Blood specimens were tested for Salivary Protein-1 (SP-1), Carbonic Anhydrase VI (CA VI), and Parotid Secretory Protein (PSP) antibodies. Salivary gland biopsies were offered when necessary to determine SjD status.

Results

304 participants completed bloodwork testing and 38 (12.5 %) were diagnosed with SjD. SjD participants had significantly higher positive rates of IgA SP-1 (21 % vs. 10 %; p = 0.049), any SP-1 autoantibody isotype (42 % vs. 24 %; p = 0.02), and a higher mean number of novel autoantibody-positive results (SjD 1.5 (1.1); non-SjD 1.0 (1.0); p = 0.005). The positive labial salivary gland biopsy group had a significantly higher rate of any PSP autoantibody isotype than the negative biopsy group (47 % vs. 22 %; p = 0.04).

Conclusions

SjD participants had significantly higher rates of IgA SP-1, any SP-1 autoantibody isotype, and a higher number of positive novel autoantibodies in general. Participants with positive salivary gland biopsies had a significantly higher prevalence of any PSP autoantibody isotype. Positivity of these tests may indicate the inflammatory nature of dry eye in these patients and could be useful for informing treatment and follow-up.

目的评价干眼病（DED）伴或不伴SjD患者中新型Sjögren's disease （SjD）自身抗体的流行情况。参与者从两个三级保健诊所招募ded患者，并根据2016年美国风湿病学会和欧洲风湿病协会联盟的标准按SjD状态进行分类。方法研究对象进行了一系列DED评估（未麻醉的Schirmer试验、泪膜破裂时间、角膜和结膜重要染料染色），以及未刺激的唾液流速评估。血液标本检测唾液蛋白1 （SP-1）、碳酸酐酶VI （CA VI）和腮腺分泌蛋白（PSP）抗体。必要时提供唾液腺活检以确定SjD状态。结果304人完成血检，38人（12.5%）确诊为SjD。SjD参与者具有更高的IgA SP-1阳性率（21%对10%，p = 0.049），任何SP-1自身抗体同种型阳性率（42%对24%，p = 0.02），以及更高的新自身抗体阳性结果的平均数量(SjD 1.5 (1.1)；非sjd 1.0 (1.0)；p = 0.005)。唇唾液腺活检阳性组出现PSP自身抗体同型的比例明显高于活检阴性组（47% vs. 22%; p = 0.04）。结论ssjd参与者的IgA SP-1和任何SP-1自身抗体同型率均显著升高，并且总体上具有较高的新型自身抗体阳性数量。唾液腺活检阳性的参与者有任何PSP自身抗体同型的显著较高的患病率。这些测试的阳性可能表明这些患者的干眼是炎症性的，可能对治疗和随访有帮助。

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