Ocular Surface最新文献

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Letter to the editor regarding “Prospective consecutive case series of patients with neurotrophic keratopathy associated with unilateral total limbal stem cell deficiency caused by severe ocular surface burns” 致编辑关于“严重眼表烧伤引起的单侧全角膜干细胞缺乏症神经营养性角膜病变患者的前瞻性连续病例系列”的信

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface

Pub Date : 2026-01-01 Epub Date: 2026-01-08 DOI: 10.1016/j.jtos.2025.11.004

Mehmet Gurdal , Ozlem Barut Selver

引用次数: 0

Letter to Editor: Prospective consecutive case series of patients with neurotrophic keratopathy associated with unilateral total limbal stem cell deficiency caused by severe ocular surface burns 致编者信：对严重眼表烧伤引起的伴有单侧全角膜缘干细胞缺乏症的神经营养性角膜病变患者进行前瞻性连续病例研究

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface

Pub Date : 2026-01-01 Epub Date: 2026-01-08 DOI: 10.1016/j.jtos.2025.11.003

Francisco Figueiredo

引用次数: 0

Umbilical cord-derived mesenchymal stem cell therapy for acute Stevens Johnson syndrome/Toxic Epidermal Necrolysis with severe ocular involvement 脐带来源间充质干细胞治疗急性史蒂文斯·约翰逊综合征/中毒性表皮坏死松解伴严重眼部受累

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface

Pub Date : 2026-01-01 Epub Date: 2025-11-24 DOI: 10.1016/j.jtos.2025.11.006

Pier Luigi Surico , Chun-Bing Chen , Chuang-Wei Wang , Tai Ping Lee , Martin Sieber , Wen-Hung Chung , Kevin Sheng-Kai Ma , Yueh-Ju Tsai , Chi-Chin Sun , David Hui-Kang Ma

引用次数: 0

Prevalence of novel Sjögren's antibodies in a multi-center cohort of dry eye patients 新型Sjögren抗体在干眼症患者多中心队列中的流行

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface

Pub Date : 2026-01-01 Epub Date: 2025-12-11 DOI: 10.1016/j.jtos.2025.12.001

David Hsu , Yinxi Yu , Esen K. Akpek , Lee W. Guo , Tiffany Liu , Mina Massaro-Giordano , Soo Abboud , Franz Fogt , Devica Bhutani , Emma Iacobucci , Jay Pendyala , Frederick B. Vivino , Alan N. Baer , Gui-shuang Ying , Vatinee Y. Bunya

Purpose

To assess the prevalence of novel Sjögren's disease (SjD) autoantibodies in dry eye disease (DED) patients with or without SjD.

Participants

DED patients were recruited from two tertiary care clinics and categorized by SjD status per the 2016 American College of Rheumatology and European Alliance of Associations for Rheumatology criteria.

Methods

Participants underwent a battery of DED evaluations (unanesthetized Schirmer's test, tear film break up time, corneal and conjunctival vital dye staining), and unstimulated salivary flow rate assessment. Blood specimens were tested for Salivary Protein-1 (SP-1), Carbonic Anhydrase VI (CA VI), and Parotid Secretory Protein (PSP) antibodies. Salivary gland biopsies were offered when necessary to determine SjD status.

Results

304 participants completed bloodwork testing and 38 (12.5 %) were diagnosed with SjD. SjD participants had significantly higher positive rates of IgA SP-1 (21 % vs. 10 %; p = 0.049), any SP-1 autoantibody isotype (42 % vs. 24 %; p = 0.02), and a higher mean number of novel autoantibody-positive results (SjD 1.5 (1.1); non-SjD 1.0 (1.0); p = 0.005). The positive labial salivary gland biopsy group had a significantly higher rate of any PSP autoantibody isotype than the negative biopsy group (47 % vs. 22 %; p = 0.04).

Conclusions

SjD participants had significantly higher rates of IgA SP-1, any SP-1 autoantibody isotype, and a higher number of positive novel autoantibodies in general. Participants with positive salivary gland biopsies had a significantly higher prevalence of any PSP autoantibody isotype. Positivity of these tests may indicate the inflammatory nature of dry eye in these patients and could be useful for informing treatment and follow-up.

目的评价干眼病（DED）伴或不伴SjD患者中新型Sjögren's disease （SjD）自身抗体的流行情况。参与者从两个三级保健诊所招募ded患者，并根据2016年美国风湿病学会和欧洲风湿病协会联盟的标准按SjD状态进行分类。方法研究对象进行了一系列DED评估（未麻醉的Schirmer试验、泪膜破裂时间、角膜和结膜重要染料染色），以及未刺激的唾液流速评估。血液标本检测唾液蛋白1 （SP-1）、碳酸酐酶VI （CA VI）和腮腺分泌蛋白（PSP）抗体。必要时提供唾液腺活检以确定SjD状态。结果304人完成血检，38人（12.5%）确诊为SjD。SjD参与者具有更高的IgA SP-1阳性率（21%对10%，p = 0.049），任何SP-1自身抗体同种型阳性率（42%对24%，p = 0.02），以及更高的新自身抗体阳性结果的平均数量(SjD 1.5 (1.1)；非sjd 1.0 (1.0)；p = 0.005)。唇唾液腺活检阳性组出现PSP自身抗体同型的比例明显高于活检阴性组（47% vs. 22%; p = 0.04）。结论ssjd参与者的IgA SP-1和任何SP-1自身抗体同型率均显著升高，并且总体上具有较高的新型自身抗体阳性数量。唾液腺活检阳性的参与者有任何PSP自身抗体同型的显著较高的患病率。这些测试的阳性可能表明这些患者的干眼是炎症性的，可能对治疗和随访有帮助。

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引用次数: 0

Corneal sensitivity in dry eye disease: A systematic review 干眼病的角膜敏感性：一项系统综述

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface

Pub Date : 2026-01-01 Epub Date: 2025-11-12 DOI: 10.1016/j.jtos.2025.11.005

Emanuele Käser , Estelle Reymond , Daniela S. Nosch

Background

Dry eye disease (DED) is a worldwide prevalent condition; however, its pathophysiology is not well understood. Corneal nerves play a primary role in DED, and a better understanding of the changes to their morphology and function is required. This systematic review investigated changes to the function of corneal nerves.

Methods

Relevant literature from inception to September 10, 2025 was searched for in PubMed, Web of Science and Scopus, following the PRISMA statement. Studies measuring corneal sensitivity in patients with DED and in healthy controls were included. Publication selection and analysis were conducted independently by two authors.

Results

Twenty-five studies involving 1580 participants (1001 with DED and 579 healthy controls) were included. Nineteen studies used the Cochet-Bonnet aesthesiometer and found a consistently reduced corneal sensitivity in patients with DED. No consistent correlation was found between corneal sensitivity and DED severity, possibly due to heterogeneity of study design and methodology. Six studies used a variant of the Belmonte air jet aesthesiometer, reporting inconsistent results for mechanical corneal sensitivity. Increased sensitivity in DED patients was reported, using a stimulus at ambient temperature. One study used the Brill aesthesiometer and found reduced corneal sensitivity in DED patients.

Conclusion

Cochet-Bonnet measurements suggest a decreased mechanical corneal sensitivity in DED patients. Air jet aesthesiometry results were inconsistent, indicating variable responses from functionally different corneal nerve endings. Future research should employ reliable corneal sensitivity measurement methods with a wide stimulus range and standardised study designs to improve understanding of changes in corneal sensitivity in dry eye disease.

干眼病（DED）是一种世界性的常见病；然而，其病理生理机制尚不清楚。角膜神经在DED中起主要作用，需要更好地了解其形态和功能的变化。本系统综述研究了角膜神经功能的变化。方法按照PRISMA的声明，在PubMed、Web of Science和Scopus中检索成立至2025年9月10日的相关文献。研究测量了DED患者和健康对照的角膜敏感性。出版物选择和分析由两位作者独立进行。结果共纳入25项研究，共1580名受试者（1001名DED患者和579名健康对照）。19项研究使用Cochet-Bonnet美感计，发现DED患者的角膜敏感性持续降低。角膜敏感性和DED严重程度之间没有一致的相关性，可能是由于研究设计和方法的异质性。六项研究使用了贝尔蒙特喷气美感计的一种变体，报告了机械角膜敏感度不一致的结果。据报道，在环境温度下使用刺激会增加DED患者的敏感性。一项使用Brill美感计的研究发现，DED患者的角膜敏感度降低。结论cochet - bonnet测量提示DED患者角膜机械敏感性降低。喷气美感测量结果不一致，表明不同功能的角膜神经末梢的不同反应。未来的研究应采用可靠的角膜敏感性测量方法、广泛的刺激范围和标准化的研究设计，以提高对干眼病角膜敏感性变化的认识。

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引用次数: 0

Response to: “Reassessing interdisciplinary approaches to belantamab mafodotin-induced ocular toxicity: towards a standardized collaborative model ” 回复：“重新评估贝兰他单抗马弗多汀引起的眼部毒性的跨学科方法：朝着标准化的合作模式发展”

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface

Pub Date : 2026-01-01 Epub Date: 2026-01-08 DOI: 10.1016/j.jtos.2025.11.008

Mattan Arazi , Irina S. Barequet

引用次数: 0

Age- and sex-dependent metabolic signatures in human meibomian glands: Insights from untargeted metabolomics 人类睑板腺的年龄和性别依赖性代谢特征：来自非靶向代谢组学的见解

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface

Pub Date : 2026-01-01 Epub Date: 2025-12-17 DOI: 10.1016/j.jtos.2025.12.002

Yaoyao Ren , Qiuyan Zhang , Min Ke , Yang Liu

引用次数: 0

Reassessing interdisciplinary approaches to belantamab mafodotin-induced ocular toxicity: Towards a standardized collaborative model 重新评估贝兰他单抗马弗多汀引起的眼毒性的跨学科方法：朝着标准化的合作模式

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface

Pub Date : 2026-01-01 Epub Date: 2026-01-08 DOI: 10.1016/j.jtos.2025.11.007

Parth Aphale, Shashank Dokania, Himanshu Shekhar

引用次数: 0

Antibiotic resistance of Pseudomonas aeruginosa from ocular samples in Canada: a 25-year analysis 加拿大眼部样本中铜绿假单胞菌的抗生素耐药性：25年分析。

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface

Pub Date : 2025-10-01 Epub Date: 2025-07-30 DOI: 10.1016/j.jtos.2025.07.011

Alfonso Iovieno , Barbara Burgos-Blasco , Derek Chan , Sean Ling , Simon Holland , Sonia N. Yeung

Objective

To identify trends in antibiotic resistance patterns of Pseudomonas aeruginosa (PA) over a multi-decade period and analyse clinical outcomes.

Methods

PA isolates from ocular samples were collected over a 25-year time period in British Columbia, Canada. Source and antibiotic resistance were recorded. Demographic data, previous ocular history and clinical outcomes of patients with PA keratitis were analysed and compared in moxifloxacin-resistant versus moxifloxacin-sensitive PA keratitis cases.

Results

321 ocular isolates of Pseudomonas were identified, 297 (92.5 %) of which were PA (101, 34 % cornea samples). Resistance to chloramphenicol was 88.7 %, 23.7 % to moxifloxacin and 10.1 % to meropenem. An increase in moxifloxacin resistance and non-susceptibility was noted, with a decrease in tobramycin resistance. The same trend was not observed for other fluroquinolone antibiotics. 14 (4.7 %) PA isolates were multi drug-resistant. 53 PA corneal isolates were included in the clinical analysis: 21 (40 %) sensitive, 17 (32 %) intermediate and 15 (28 %) resistant to moxifloxacin. Non-susceptible PA patients were older, more frequently non-contact lens wearers and a had a higher prevalence of previous ocular surgeries and topical treatment. A lower clinical response to initial treatment was observed in resistant cases. Need for surgery and complications were higher among moxifloxacin-resistant cases.

Conclusions

This study reports for the first time in North America a progressive and significant increase in moxifloxacin resistance among PA isolates. Overuse of topical moxifloxacin may be underlying this finding. Given the worse clinical outcomes in resistant cases, we would caution against the use of moxifloxacin alone as empirical treatment of infectious keratitis.

目的：确定铜绿假单胞菌（PA）耐药性模式的趋势，并分析其临床结果。方法：从加拿大不列颠哥伦比亚省的眼部样本中收集了25年的PA分离物。记录来源及抗生素耐药性。分析并比较莫西沙星耐药和莫西沙星敏感的PA角膜炎患者的人口统计学资料、既往眼部病史和临床结果。结果：共检出321株假单胞菌，其中PA 297株（92.5%），占角膜标本的101.34%。氯霉素耐药率为88.7%，莫西沙星耐药率为23.7%，美罗培南耐药率为10.1%。莫西沙星耐药和非敏感性增加，妥布霉素耐药减少。其他氟喹诺酮类抗生素没有观察到同样的趋势。14株（4.7%）PA分离株多重耐药。临床分析53株PA角膜分离株：对莫西沙星敏感21株（40%），中间17株（32%），耐药15株（28%）。非易感PA患者年龄较大，经常佩戴非隐形眼镜，既往眼部手术和局部治疗的患病率较高。耐药病例对初始治疗的临床反应较低。莫西沙星耐药病例的手术需求和并发症较高。结论：本研究首次在北美报道了PA分离株中莫西沙星耐药性的进展性和显著性增加。过量使用局部莫西沙星可能是这一发现的基础。鉴于耐药病例的临床结果较差，我们建议不要单独使用莫西沙星作为感染性角膜炎的经验性治疗。

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引用次数: 0

Readership awareness series – Paper 9: Retraction of a publication 读者意识系列 - 文件 9：撤回出版物

IF 5.6 1区医学 Q1 OPHTHALMOLOGY

Ocular Surface

Pub Date : 2025-10-01 Epub Date: 2024-01-17 DOI: 10.1016/j.jtos.2024.01.008

Mohammad Javed Ali (Editor-in-Chief), Ali Djalilian (Former Editor-in-Chief)

引用次数: 0

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