Ocular Surface最新文献

{"title":"AZR-MD-001 0.5% selenium sulfide ophthalmic ointment for the treatment of contact lens discomfort: A vehicle-controlled, randomized, clinical trial","authors":"Fiona Stapleton ,&nbsp;Mark Hinds ,&nbsp;Jacqueline Tan ,&nbsp;Lyndon Jones ,&nbsp;Robin Chalmers ,&nbsp;Charles Bosworth ,&nbsp;Yair Alster","doi":"10.1016/j.jtos.2024.12.009","DOIUrl":"10.1016/j.jtos.2024.12.009","url":null,"abstract":"<div><h3>Background</h3><div>Contact lens discomfort (CLD) is a common problem for CL wearers, and patients with CLD often have changes in meibomian gland function and structure. In a Phase 2 trial AZR-MD-001 0.5% (AZR) ophthalmic ointment improved meibomian gland dysfunction (MGD) in non-lens wearers. The current study evaluated the efficacy and safety of AZR in participants with CLD and concomitant MGD.</div></div><div><h3>Methods</h3><div>Adults with CLD (Contact Lens Dry Eye Questionnaire-8 &gt;12, range 0–37) and MGD (Meibomian Gland Secretion Score [MGS] ≤12, range 0–45) were randomized (1:1) to AZR:vehicle applied twice-weekly in a three-month multicenter, prospective, double-masked study. Endpoints included difference in change from baseline (CFB) in the number of Meibomian Glands Yielding Liquid Secretion (MGYLS), MGS, the ability to wear their lenses as long as desired, and safety.</div></div><div><h3>Results</h3><div>At Month 3, AZR (n = 34) significantly increased the MGYLS and MGS versus vehicle (n = 33), with least squares mean difference (LSMD) CFB in MGYLS of 5.0 (SE = 0.47) for AZR and 1.6 (0.45) for vehicle, <em>P</em> &lt; 0.0001; MGS of 13.8 (SE = 0.67) for AZR and 3.8 (SE = 0.68) for vehicle, <em>P</em> &lt; 0.0001. Significantly more participants treated with AZR were able to wear lenses as long as desired (43% vs. 6%, <em>P</em> = 0.0023). The most common treatment-emergent adverse event (TEAE) was eye irritation (61.8% AZR; 0% vehicle). All TEAEs related to treatment were mild/moderate, transient, and did not result in discontinuation.</div></div><div><h3>Conclusion</h3><div>AZR-MD-001 0.5% significantly improved MGD signs and hours of comfortable CL wear, demonstrating good efficacy, safety, and tolerability in those with CLD.</div></div>","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"38 ","pages":"Pages 431-439"},"PeriodicalIF":5.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric vs adult Stevens Johnson syndrome/toxic epidermal necrolysis: Ocular outcomes and the role of amniotic membrane","authors":"","doi":"10.1016/j.jtos.2025.10.008","DOIUrl":"10.1016/j.jtos.2025.10.008","url":null,"abstract":"","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"38 ","pages":"Pages 388-389"},"PeriodicalIF":5.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145412015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Significant errors in the paper by Ballesteros-Sánchez A, Rocha-de-Lossada C and Sánchez-González J. Efficacy of eyelid warming devices as first-step treatment in meibomian gland dysfunction: A systematic review with meta-analysis. 2025; 37:33–46","authors":"Jacqueline Tan","doi":"10.1016/j.jtos.2025.04.003","DOIUrl":"10.1016/j.jtos.2025.04.003","url":null,"abstract":"","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"38 ","pages":"Pages 443-444"},"PeriodicalIF":5.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic and genotypic profiling of antimicrobial resistance genes and virulence factors in Pseudomonas aeruginosa isolates from keratitis patients","authors":"Abiye Tigabu ,&nbsp;Mark D.P. Willcox ,&nbsp;Fiona Stapleton","doi":"10.1016/j.jtos.2025.10.011","DOIUrl":"10.1016/j.jtos.2025.10.011","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;&lt;em&gt;Pseudomonas aeruginosa&lt;/em&gt; (&lt;em&gt;P. aeruginosa&lt;/em&gt;) is a major cause of ocular infections, exhibiting resistance to many antimicrobial agents and the ability to acquire further resistance through mutations and horizontal gene transfer. It employs a range of virulence factors to invade ocular tissues, leading to complications such as corneal scarring and perforation. Alarmingly, multidrug-resistant &lt;em&gt;P. aeruginosa&lt;/em&gt; isolates are increasing worldwide. For instance, a recent outbreak in the United States of America (USA) involving an extensively drug-resistant &lt;em&gt;P. aeruginosa&lt;/em&gt; PA1270 strain resulted in four deaths, four eye removals, and 14 cases of vision loss. A comprehensive understanding of the antibiotic resistance and virulence mechanisms of &lt;em&gt;P. aeruginosa&lt;/em&gt; is essential for the effective management of corneal infections.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Whole-genome sequencing data from 70 &lt;em&gt;P. aeruginosa&lt;/em&gt; isolates collected from corneal samples were retrieved from the National Center for Biotechnology Information (NCBI) database and annotated using Prokka 1.14.6. Unique genes identified in these datasets were analyzed against the Comprehensive Antibiotic Resistance Database (CARD) to determine antimicrobial resistance profiles. The presence of acquired resistance genes and virulence factors were assessed using ResFinder and the Virulence Factor Database (VFDB), respectively. Roary v3.13.0 was used for pangenome analysis, while Snippy v4.6.0 was employed for whole-genome variant analysis. Furthermore, mobile genetic elements (MGEs) and pathogenicity islands (PIs) were identified using MobileElementFinder v1.0.3 and IslandViewer 4, respectively. In parallel, phenotypic characterization, including determination of minimum inhibitory concentrations (MICs) for selected antimicrobial agents, was performed using the broth microdilution method. Additionally, a crystal violet assay was conducted to evaluate the biofilm-forming ability of &lt;em&gt;P. aeruginosa&lt;/em&gt;.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;The corneal &lt;em&gt;P. aeruginosa&lt;/em&gt; harboured numerous AMR genes against various classes of antibiotics. Notably, the most prevalent acquired resistance genes across all keratitis &lt;em&gt;P. aeruginosa&lt;/em&gt; strains were β-lactams &lt;em&gt;blaPAO&lt;/em&gt;, and &lt;em&gt;blaOXA&lt;/em&gt;, aminoglycoside &lt;em&gt;aph(3′)-IIb&lt;/em&gt;, chloramphenicol &lt;em&gt;catB7&lt;/em&gt;, and fosfomycin &lt;em&gt;fosA&lt;/em&gt;. &lt;em&gt;P. aeruginosa&lt;/em&gt; keratitis isolates harbored more core and cloud genes than environmental and cystic fibrosis (CF) strains. A significant difference in ciprofloxacin resistance gene &lt;em&gt;crpP&lt;/em&gt; was observed between the keratitis and CF isolates. Additionally, a considerable number of insertion sequences (ISPa1, ISPa6, ISPa32) and transposons (Tn4661, Tn6082, Tn5563) were identified. Phenotypic characterization of antimicrobial resistance (AMR) revealed that gentamicin were the most effective antibiotics against corneal &lt;em&gt;P. aerugino","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"38 ","pages":"Pages 392-420"},"PeriodicalIF":5.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145405030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to letter to the editor regarding “Simple limbal epithelial transplantation versus cultivated limbal epithelial transplantation in ocular burns”","authors":"Namrata Sharma,&nbsp;Renu Venugopal,&nbsp;Sujata Mohanty,&nbsp;Kamalakannan Priyadarshini,&nbsp;Ritu Nagpal,&nbsp;Deepali Singhal,&nbsp;Aafreen Bari,&nbsp;Tanuj Dada,&nbsp;Prafulla Kumar Maharana,&nbsp;Tushar Agarwal,&nbsp;Ashish Dutt Upadhyay","doi":"10.1016/j.jtos.2025.07.007","DOIUrl":"10.1016/j.jtos.2025.07.007","url":null,"abstract":"","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"38 ","pages":"Pages 447-448"},"PeriodicalIF":5.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular manifestations in Stevens‒Johnson syndrome/toxic epidermal necrolysis in cancer patients","authors":"Jin-Jhe Wang ,&nbsp;Chun-Bing Chen ,&nbsp;Eugene Yu-Chuan Kang ,&nbsp;Wen-Hung Chung ,&nbsp;John Wen-Cheng Chang ,&nbsp;Kevin Sheng-Kai Ma ,&nbsp;Yueh-Ju Tsai ,&nbsp;Ming-Tse Kuo ,&nbsp;Chi-Chin Sun ,&nbsp;Hung-Chi Chen ,&nbsp;Shin-Yi Chen ,&nbsp;Kuo-Hsuan Hung ,&nbsp;Hsin-Yuan Tan ,&nbsp;Pier Luigi Surico ,&nbsp;David Hui-Kang Ma","doi":"10.1016/j.jtos.2025.10.010","DOIUrl":"10.1016/j.jtos.2025.10.010","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the characteristics, risk factors, and outcomes of ocular involvement in cancer patients with Stevens‒Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), focusing on the role of immune checkpoint inhibitors (ICIs).</div></div><div><h3>Methods</h3><div>This retrospective case‒control study was conducted at Chang Gung Memorial Hospital, Linkou, Taiwan, between 2004 and 2024. A total of 112 patients with confirmed SJS/TEN and concurrent malignancies were included. The primary outcomes were the prevalence and severity of acute and chronic ocular involvement, assessed using Sotozono's classification. Risk factors for ocular involvement were investigated through univariate and multivariate logistic regression.</div></div><div><h3>Results</h3><div>Of 112 patients, 46 (41.1 %) developed ocular complications. TEN (adjusted OR, 3.11; 95 % CI, 1.24–7.78; P = 0.02), systemic mucosal involvement (adjusted OR, 4.89; 95 % CI, 1.52–15.80; P = 0.01), and polypharmacy (adjusted OR, 3.52; 95 % CI, 1.36–9.11; P = 0.01) were significant risk factors for ocular involvement. ICI-related SJS/TEN exhibited longer latency (31.0 vs. 13.4 days; P &lt; 0.001) and delayed healing (72.3 vs. 45.8 days; P = 0.002). Chronic ocular complications were more severe in surviving ICI-related patients, as indicated by significantly higher chronic Sotozono scores (7.5 vs. 3.7; P = 0.001), worse dry eye (Schirmer's test 1.8 vs. 3.4 mm; P = 0.01), and poorer visual recovery (0.11 vs. 0.43 logMAR; P = 0.001).</div></div><div><h3>Conclusions</h3><div>SJS/TEN in cancer patients, particularly those receiving ICIs, is associated with substantial ocular morbidity. The increasing prevalence of ICI-related SJS/TEN emphasizes the need for vigilant ophthalmologic intervention and long-term monitoring.</div></div>","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"38 ","pages":"Pages 367-376"},"PeriodicalIF":5.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145382680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Reply to Prof. Jacqueline Tan's letter. Efficacy of eyelid warming devices as a first-step treatment in meibomian gland dysfunction: A systematic review with meta-analysis. 2025; 37:33-46","authors":"Ballesteros-Sánchez Antonio,&nbsp;Carlos Rocha-de-Lossada,&nbsp;José-María Sánchez-González","doi":"10.1016/j.jtos.2025.04.002","DOIUrl":"10.1016/j.jtos.2025.04.002","url":null,"abstract":"","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"38 ","pages":"Pages 440-442"},"PeriodicalIF":5.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological considerations regarding \"Ranking the efficacy of topical treatments for ocular allergy: A network meta-analysis of current evidence\" [Letter]","authors":"Dror Ben Ephraim Noyman ,&nbsp;Michael Mimouni ,&nbsp;Ben Klinghoffer","doi":"10.1016/j.jtos.2025.10.006","DOIUrl":"10.1016/j.jtos.2025.10.006","url":null,"abstract":"","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"38 ","pages":"Pages 365-366"},"PeriodicalIF":5.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145383891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to “Methodological considerations regarding 'Ranking the efficacy of topical treatments for ocular allergy: A network meta-analysis of current evidence'”","authors":"Luksanaporn Krungkraipetch ,&nbsp;Taweelarp Tansavadi ,&nbsp;Dechathorn Krungkraipetch","doi":"10.1016/j.jtos.2025.10.007","DOIUrl":"10.1016/j.jtos.2025.10.007","url":null,"abstract":"","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"38 ","pages":"Pages 390-391"},"PeriodicalIF":5.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145382674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In memoriam: Professor Maurizio Rolando (1950–2025)","authors":"Stefano Bonini","doi":"10.1016/j.jtos.2025.10.003","DOIUrl":"10.1016/j.jtos.2025.10.003","url":null,"abstract":"","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"38 ","pages":"Page 449"},"PeriodicalIF":5.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145657307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}