Ocular Surface最新文献

{"title":"Recurrent retroprosthetic membranes in Boston Keratoprosthesis Type I: Incidence, risk factors, and complications","authors":"Katherine G. Chen ,&nbsp;Taylor W. Starnes ,&nbsp;Sasha Kravets ,&nbsp;Shanta Ghosh ,&nbsp;Jose de la Cruz ,&nbsp;Maria S. Cortina","doi":"10.1016/j.jtos.2025.11.002","DOIUrl":"10.1016/j.jtos.2025.11.002","url":null,"abstract":"<div><h3>Purpose</h3><div>To identify pre-operative surgical factors associated with recurrent retroprosthetic membranes (RPMs) after Boston Keratoprosthesis (KPro) implantation, and to compare outcomes of patients with recurrent RPMs to those who had single or no RPM formation.</div></div><div><h3>Methods</h3><div>A single-center, retrospective study of all patients who underwent Boston Type I KPro implantation between 2006 and 2017 was performed. Patients with less than 1 year follow-up after device implantation were excluded. Patients were divided into 3 groups – no RPM, single RPM, and recurrent RPM. Recurrent RPM was defined as ≥2 visually significant RPM during follow-up. Statistical analysis was performed to assess factors associated with RPM status. Primary outcome measures included best-corrected visual acuity at 1 year and the need for RPM-related surgeries.</div></div><div><h3>Results</h3><div>109 of 148 KPro patients met the inclusion criteria. 45 % of patients had no RPM, 36.7 % had a single RPM, and 18.3 % had recurrent RPMs. At 1-year follow-up, visual acuity was decreased in both the recurrent (LogMAR 1.6) and single RPM (LogMar 1.18) groups compared to eyes with no RPM (LogMar 0.94). Eyes with recurrent RPM also required a significantly higher proportion of RPM-related surgery (p &lt; 0.001). Eyes without prior penetrating keratoplasty (p = 0.04), pre-operative aniridia (p = 0.01), and post-operative occurrence of retinal detachments (p &lt; 0.001) and corneal melts (p &lt; 0.001) were found to be statistically significantly associated with RPM status.</div></div><div><h3>Conclusions</h3><div>Retroprosthetic membranes, especially when recurrent, play an important role in the secondary complications, visual outcomes, and device retention after KPro implantation.</div></div>","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"38 ","pages":"Pages 424-430"},"PeriodicalIF":5.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145509653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recanalization of lacrimal punctum after cauterization for severe dry eyes: Evidence for punctal progenitor cells","authors":"Sumer Doctor ,&nbsp;Vidhi Anklesaria ,&nbsp;Swati Singh","doi":"10.1016/j.jtos.2025.11.001","DOIUrl":"10.1016/j.jtos.2025.11.001","url":null,"abstract":"","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"38 ","pages":"Pages 421-423"},"PeriodicalIF":5.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145447250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric vs adult Stevens Johnson syndrome/toxic epidermal necrolysis: Ocular outcomes and the role of amniotic membrane","authors":"","doi":"10.1016/j.jtos.2025.10.008","DOIUrl":"10.1016/j.jtos.2025.10.008","url":null,"abstract":"","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"38 ","pages":"Pages 388-389"},"PeriodicalIF":5.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145412015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Significant errors in the paper by Ballesteros-Sánchez A, Rocha-de-Lossada C and Sánchez-González J. Efficacy of eyelid warming devices as first-step treatment in meibomian gland dysfunction: A systematic review with meta-analysis. 2025; 37:33–46","authors":"Jacqueline Tan","doi":"10.1016/j.jtos.2025.04.003","DOIUrl":"10.1016/j.jtos.2025.04.003","url":null,"abstract":"","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"38 ","pages":"Pages 443-444"},"PeriodicalIF":5.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic and genotypic profiling of antimicrobial resistance genes and virulence factors in Pseudomonas aeruginosa isolates from keratitis patients","authors":"Abiye Tigabu ,&nbsp;Mark D.P. Willcox ,&nbsp;Fiona Stapleton","doi":"10.1016/j.jtos.2025.10.011","DOIUrl":"10.1016/j.jtos.2025.10.011","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;&lt;em&gt;Pseudomonas aeruginosa&lt;/em&gt; (&lt;em&gt;P. aeruginosa&lt;/em&gt;) is a major cause of ocular infections, exhibiting resistance to many antimicrobial agents and the ability to acquire further resistance through mutations and horizontal gene transfer. It employs a range of virulence factors to invade ocular tissues, leading to complications such as corneal scarring and perforation. Alarmingly, multidrug-resistant &lt;em&gt;P. aeruginosa&lt;/em&gt; isolates are increasing worldwide. For instance, a recent outbreak in the United States of America (USA) involving an extensively drug-resistant &lt;em&gt;P. aeruginosa&lt;/em&gt; PA1270 strain resulted in four deaths, four eye removals, and 14 cases of vision loss. A comprehensive understanding of the antibiotic resistance and virulence mechanisms of &lt;em&gt;P. aeruginosa&lt;/em&gt; is essential for the effective management of corneal infections.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Whole-genome sequencing data from 70 &lt;em&gt;P. aeruginosa&lt;/em&gt; isolates collected from corneal samples were retrieved from the National Center for Biotechnology Information (NCBI) database and annotated using Prokka 1.14.6. Unique genes identified in these datasets were analyzed against the Comprehensive Antibiotic Resistance Database (CARD) to determine antimicrobial resistance profiles. The presence of acquired resistance genes and virulence factors were assessed using ResFinder and the Virulence Factor Database (VFDB), respectively. Roary v3.13.0 was used for pangenome analysis, while Snippy v4.6.0 was employed for whole-genome variant analysis. Furthermore, mobile genetic elements (MGEs) and pathogenicity islands (PIs) were identified using MobileElementFinder v1.0.3 and IslandViewer 4, respectively. In parallel, phenotypic characterization, including determination of minimum inhibitory concentrations (MICs) for selected antimicrobial agents, was performed using the broth microdilution method. Additionally, a crystal violet assay was conducted to evaluate the biofilm-forming ability of &lt;em&gt;P. aeruginosa&lt;/em&gt;.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;The corneal &lt;em&gt;P. aeruginosa&lt;/em&gt; harboured numerous AMR genes against various classes of antibiotics. Notably, the most prevalent acquired resistance genes across all keratitis &lt;em&gt;P. aeruginosa&lt;/em&gt; strains were β-lactams &lt;em&gt;blaPAO&lt;/em&gt;, and &lt;em&gt;blaOXA&lt;/em&gt;, aminoglycoside &lt;em&gt;aph(3′)-IIb&lt;/em&gt;, chloramphenicol &lt;em&gt;catB7&lt;/em&gt;, and fosfomycin &lt;em&gt;fosA&lt;/em&gt;. &lt;em&gt;P. aeruginosa&lt;/em&gt; keratitis isolates harbored more core and cloud genes than environmental and cystic fibrosis (CF) strains. A significant difference in ciprofloxacin resistance gene &lt;em&gt;crpP&lt;/em&gt; was observed between the keratitis and CF isolates. Additionally, a considerable number of insertion sequences (ISPa1, ISPa6, ISPa32) and transposons (Tn4661, Tn6082, Tn5563) were identified. Phenotypic characterization of antimicrobial resistance (AMR) revealed that gentamicin were the most effective antibiotics against corneal &lt;em&gt;P. aerugino","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"38 ","pages":"Pages 392-420"},"PeriodicalIF":5.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145405030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to letter to the editor regarding “Simple limbal epithelial transplantation versus cultivated limbal epithelial transplantation in ocular burns”","authors":"Namrata Sharma,&nbsp;Renu Venugopal,&nbsp;Sujata Mohanty,&nbsp;Kamalakannan Priyadarshini,&nbsp;Ritu Nagpal,&nbsp;Deepali Singhal,&nbsp;Aafreen Bari,&nbsp;Tanuj Dada,&nbsp;Prafulla Kumar Maharana,&nbsp;Tushar Agarwal,&nbsp;Ashish Dutt Upadhyay","doi":"10.1016/j.jtos.2025.07.007","DOIUrl":"10.1016/j.jtos.2025.07.007","url":null,"abstract":"","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"38 ","pages":"Pages 447-448"},"PeriodicalIF":5.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular manifestations in Stevens‒Johnson syndrome/toxic epidermal necrolysis in cancer patients","authors":"Jin-Jhe Wang ,&nbsp;Chun-Bing Chen ,&nbsp;Eugene Yu-Chuan Kang ,&nbsp;Wen-Hung Chung ,&nbsp;John Wen-Cheng Chang ,&nbsp;Kevin Sheng-Kai Ma ,&nbsp;Yueh-Ju Tsai ,&nbsp;Ming-Tse Kuo ,&nbsp;Chi-Chin Sun ,&nbsp;Hung-Chi Chen ,&nbsp;Shin-Yi Chen ,&nbsp;Kuo-Hsuan Hung ,&nbsp;Hsin-Yuan Tan ,&nbsp;Pier Luigi Surico ,&nbsp;David Hui-Kang Ma","doi":"10.1016/j.jtos.2025.10.010","DOIUrl":"10.1016/j.jtos.2025.10.010","url":null,"abstract":"<div><h3>Purpose</h3><div>To evaluate the characteristics, risk factors, and outcomes of ocular involvement in cancer patients with Stevens‒Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), focusing on the role of immune checkpoint inhibitors (ICIs).</div></div><div><h3>Methods</h3><div>This retrospective case‒control study was conducted at Chang Gung Memorial Hospital, Linkou, Taiwan, between 2004 and 2024. A total of 112 patients with confirmed SJS/TEN and concurrent malignancies were included. The primary outcomes were the prevalence and severity of acute and chronic ocular involvement, assessed using Sotozono's classification. Risk factors for ocular involvement were investigated through univariate and multivariate logistic regression.</div></div><div><h3>Results</h3><div>Of 112 patients, 46 (41.1 %) developed ocular complications. TEN (adjusted OR, 3.11; 95 % CI, 1.24–7.78; P = 0.02), systemic mucosal involvement (adjusted OR, 4.89; 95 % CI, 1.52–15.80; P = 0.01), and polypharmacy (adjusted OR, 3.52; 95 % CI, 1.36–9.11; P = 0.01) were significant risk factors for ocular involvement. ICI-related SJS/TEN exhibited longer latency (31.0 vs. 13.4 days; P &lt; 0.001) and delayed healing (72.3 vs. 45.8 days; P = 0.002). Chronic ocular complications were more severe in surviving ICI-related patients, as indicated by significantly higher chronic Sotozono scores (7.5 vs. 3.7; P = 0.001), worse dry eye (Schirmer's test 1.8 vs. 3.4 mm; P = 0.01), and poorer visual recovery (0.11 vs. 0.43 logMAR; P = 0.001).</div></div><div><h3>Conclusions</h3><div>SJS/TEN in cancer patients, particularly those receiving ICIs, is associated with substantial ocular morbidity. The increasing prevalence of ICI-related SJS/TEN emphasizes the need for vigilant ophthalmologic intervention and long-term monitoring.</div></div>","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"38 ","pages":"Pages 367-376"},"PeriodicalIF":5.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145382680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Reply to Prof. Jacqueline Tan's letter. Efficacy of eyelid warming devices as a first-step treatment in meibomian gland dysfunction: A systematic review with meta-analysis. 2025; 37:33-46","authors":"Ballesteros-Sánchez Antonio,&nbsp;Carlos Rocha-de-Lossada,&nbsp;José-María Sánchez-González","doi":"10.1016/j.jtos.2025.04.002","DOIUrl":"10.1016/j.jtos.2025.04.002","url":null,"abstract":"","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"38 ","pages":"Pages 440-442"},"PeriodicalIF":5.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological considerations regarding \"Ranking the efficacy of topical treatments for ocular allergy: A network meta-analysis of current evidence\" [Letter]","authors":"Dror Ben Ephraim Noyman ,&nbsp;Michael Mimouni ,&nbsp;Ben Klinghoffer","doi":"10.1016/j.jtos.2025.10.006","DOIUrl":"10.1016/j.jtos.2025.10.006","url":null,"abstract":"","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"38 ","pages":"Pages 365-366"},"PeriodicalIF":5.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145383891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to “Methodological considerations regarding 'Ranking the efficacy of topical treatments for ocular allergy: A network meta-analysis of current evidence'”","authors":"Luksanaporn Krungkraipetch ,&nbsp;Taweelarp Tansavadi ,&nbsp;Dechathorn Krungkraipetch","doi":"10.1016/j.jtos.2025.10.007","DOIUrl":"10.1016/j.jtos.2025.10.007","url":null,"abstract":"","PeriodicalId":54691,"journal":{"name":"Ocular Surface","volume":"38 ","pages":"Pages 390-391"},"PeriodicalIF":5.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145382674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}