首页 > 最新文献

New England Journal of Medicine最新文献

英文 中文
The Way to a Patient's Heart - Vascular Access in Cardiac Arrest. 通往病人心脏之路--心脏骤停时的血管通路。
IF 96.2 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-10-31 DOI: 10.1056/NEJMe2412901
Niklas Nielsen
{"title":"The Way to a Patient's Heart - Vascular Access in Cardiac Arrest.","authors":"Niklas Nielsen","doi":"10.1056/NEJMe2412901","DOIUrl":"https://doi.org/10.1056/NEJMe2412901","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":96.2,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lead Poisoning. 铅中毒。
IF 96.2 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-10-31 DOI: 10.1056/NEJMra2402527
Bruce Lanphear, Ana Navas-Acien, David C Bellinger
{"title":"Lead Poisoning.","authors":"Bruce Lanphear, Ana Navas-Acien, David C Bellinger","doi":"10.1056/NEJMra2402527","DOIUrl":"https://doi.org/10.1056/NEJMra2402527","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":96.2,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Total Hip Replacement or Resistance Training for Severe Hip Osteoarthritis. 严重髋关节骨性关节炎的全髋关节置换术还是阻力训练?
IF 96.2 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-10-31 DOI: 10.1056/NEJMoa2400141
Thomas Frydendal, Robin Christensen, Inger Mechlenburg, Lone R Mikkelsen, Claus Varnum, Anders E Graversen, Per Kjærsgaard-Andersen, Peter H Revald, Christian Hofbauer, Manuel J Bieder, Haidar Qassim, Mohammad S Munir, Stig S Jakobsen, Sabrina M Nielsen, Kim G Ingwersen, Søren Overgaard

Background: Total hip replacement is routinely recommended for severe hip osteoarthritis, but data from randomized trials are lacking regarding comparison of the effectiveness of this procedure with that of nonsurgical treatment such as resistance training.

Methods: We conducted a multicenter, randomized, controlled trial to compare total hip replacement with resistance training in patients 50 years of age or older who had severe hip osteoarthritis and an indication for surgery. The primary outcome was the change in patient-reported hip pain and function from baseline to 6 months after the initiation of treatment, assessed with the use of the Oxford Hip Score (range, 0 to 48, with higher scores indicating less pain and better function). Safety was also assessed.

Results: A total of 109 patients (mean age, 67.6 years) were randomly assigned to total hip replacement (53 patients) or resistance training (56 patients). In an intention-to-treat analysis, the mean increase (indicating improvement) in the Oxford Hip Score was 15.9 points in patients assigned to total hip replacement and 4.5 points in patients assigned to resistance training (difference, 11.4 points; 95% confidence interval, 8.9 to 14.0; P<0.001). At 6 months, 5 patients (9%) who had been assigned to total hip replacement had not undergone surgery, and 12 patients (21%) who had been assigned to resistance training had undergone total hip replacement. The incidence of serious adverse events at 6 months was similar in the two groups; the majority of such events were known complications of total hip replacement.

Conclusions: In patients 50 years of age or older who had severe hip osteoarthritis and an indication for surgery, total hip replacement resulted in a clinically important, superior reduction in hip pain and improved hip function, as reported by patients, at 6 months as compared with resistance training. (Funded by the Danish Rheumatism Association and others; PROHIP ClinicalTrials.gov number, NCT04070027.).

背景:全髋关节置换术是治疗严重髋关节骨性关节炎的常规建议,但缺乏随机试验的数据,无法比较该手术与阻力训练等非手术治疗的效果:我们进行了一项多中心随机对照试验,对 50 岁或以上患有严重髋关节骨关节炎且有手术指征的患者进行全髋关节置换术与阻力训练的比较。主要结果是患者报告的髋关节疼痛和功能从基线到治疗开始后 6 个月的变化,使用牛津髋关节评分进行评估(范围从 0 到 48,分数越高表示疼痛越轻、功能越好)。此外,还对安全性进行了评估:共有 109 名患者(平均年龄 67.6 岁)被随机分配接受全髋关节置换术(53 人)或阻力训练(56 人)。在意向治疗分析中,接受全髋关节置换术的患者的牛津髋关节评分平均提高了 15.9 分,而接受阻力训练的患者的牛津髋关节评分平均提高了 4.5 分(差异为 11.4 分;95% 置信区间为 8.9-14.0 分):对于 50 岁或以上患有严重髋关节骨关节炎且有手术指征的患者,与阻力训练相比,全髋关节置换术可在 6 个月后显著减轻髋关节疼痛并改善髋关节功能。(由丹麦风湿病协会和其他机构资助;PROHIP ClinicalTrials.gov 编号:NCT04070027)。
{"title":"Total Hip Replacement or Resistance Training for Severe Hip Osteoarthritis.","authors":"Thomas Frydendal, Robin Christensen, Inger Mechlenburg, Lone R Mikkelsen, Claus Varnum, Anders E Graversen, Per Kjærsgaard-Andersen, Peter H Revald, Christian Hofbauer, Manuel J Bieder, Haidar Qassim, Mohammad S Munir, Stig S Jakobsen, Sabrina M Nielsen, Kim G Ingwersen, Søren Overgaard","doi":"10.1056/NEJMoa2400141","DOIUrl":"https://doi.org/10.1056/NEJMoa2400141","url":null,"abstract":"<p><strong>Background: </strong>Total hip replacement is routinely recommended for severe hip osteoarthritis, but data from randomized trials are lacking regarding comparison of the effectiveness of this procedure with that of nonsurgical treatment such as resistance training.</p><p><strong>Methods: </strong>We conducted a multicenter, randomized, controlled trial to compare total hip replacement with resistance training in patients 50 years of age or older who had severe hip osteoarthritis and an indication for surgery. The primary outcome was the change in patient-reported hip pain and function from baseline to 6 months after the initiation of treatment, assessed with the use of the Oxford Hip Score (range, 0 to 48, with higher scores indicating less pain and better function). Safety was also assessed.</p><p><strong>Results: </strong>A total of 109 patients (mean age, 67.6 years) were randomly assigned to total hip replacement (53 patients) or resistance training (56 patients). In an intention-to-treat analysis, the mean increase (indicating improvement) in the Oxford Hip Score was 15.9 points in patients assigned to total hip replacement and 4.5 points in patients assigned to resistance training (difference, 11.4 points; 95% confidence interval, 8.9 to 14.0; P<0.001). At 6 months, 5 patients (9%) who had been assigned to total hip replacement had not undergone surgery, and 12 patients (21%) who had been assigned to resistance training had undergone total hip replacement. The incidence of serious adverse events at 6 months was similar in the two groups; the majority of such events were known complications of total hip replacement.</p><p><strong>Conclusions: </strong>In patients 50 years of age or older who had severe hip osteoarthritis and an indication for surgery, total hip replacement resulted in a clinically important, superior reduction in hip pain and improved hip function, as reported by patients, at 6 months as compared with resistance training. (Funded by the Danish Rheumatism Association and others; PROHIP ClinicalTrials.gov number, NCT04070027.).</p>","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":96.2,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case 22-2024: A Woman with Postpartum Fever, Abdominal Pain, and Skin Ulcers. 病例 22-2024:一名产后发烧、腹痛和皮肤溃疡的妇女。
IF 96.2 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-10-31 DOI: 10.1056/NEJMc2410558
Konstantinos Parperis
{"title":"Case 22-2024: A Woman with Postpartum Fever, Abdominal Pain, and Skin Ulcers.","authors":"Konstantinos Parperis","doi":"10.1056/NEJMc2410558","DOIUrl":"10.1056/NEJMc2410558","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":96.2,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toward a Biomedical Research Enterprise That Better Serves the United States. 建立一个更好地为美国服务的生物医学研究企业。
IF 96.2 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-10-31 Epub Date: 2024-10-01 DOI: 10.1056/NEJMsb2412007
E Albert Reece, Victor J Dzau
{"title":"Toward a Biomedical Research Enterprise That Better Serves the United States.","authors":"E Albert Reece, Victor J Dzau","doi":"10.1056/NEJMsb2412007","DOIUrl":"10.1056/NEJMsb2412007","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":96.2,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Failing U.S. Health System. 失败的美国医疗系统。
IF 96.2 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-10-31 Epub Date: 2024-10-09 DOI: 10.1056/NEJMp2410855
David Blumenthal, Evan Gumas, Arnav Shah
{"title":"The Failing U.S. Health System.","authors":"David Blumenthal, Evan Gumas, Arnav Shah","doi":"10.1056/NEJMp2410855","DOIUrl":"10.1056/NEJMp2410855","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":96.2,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving the Outcome of Bad-Acting Hormone Receptor-Positive Breast Cancer. 改善不良反应激素受体阳性乳腺癌的治疗效果。
IF 96.2 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-10-31 DOI: 10.1056/NEJMe2411229
William J Gradishar
{"title":"Improving the Outcome of Bad-Acting Hormone Receptor-Positive Breast Cancer.","authors":"William J Gradishar","doi":"10.1056/NEJMe2411229","DOIUrl":"https://doi.org/10.1056/NEJMe2411229","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":96.2,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
More on Type 2 Diabetes in Patients with G6PD Deficiency. Reply. 关于 G6PD 缺乏症患者 2 型糖尿病的更多信息。回复。
IF 96.2 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-10-31 DOI: 10.1056/NEJMc2411261
Ariel Israel, Shlomo Vinker, Eugene Merzon
{"title":"More on Type 2 Diabetes in Patients with G6PD Deficiency. Reply.","authors":"Ariel Israel, Shlomo Vinker, Eugene Merzon","doi":"10.1056/NEJMc2411261","DOIUrl":"10.1056/NEJMc2411261","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":96.2,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
APOE3 Christchurch Heterozygosity and Autosomal Dominant Alzheimer's Disease. APOE3 克赖斯特彻奇杂合子与常染色体显性阿尔茨海默病
IF 96.2 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-10-31 DOI: 10.1056/NEJMc2409320
J Nicholas Cochran, Michael D Greicius, Alison M Goate
{"title":"APOE3 Christchurch Heterozygosity and Autosomal Dominant Alzheimer's Disease.","authors":"J Nicholas Cochran, Michael D Greicius, Alison M Goate","doi":"10.1056/NEJMc2409320","DOIUrl":"https://doi.org/10.1056/NEJMc2409320","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":96.2,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glucagon-Like Peptide-1 Receptor Agonists and Osteoarthritis. 胰高血糖素样肽-1 受体激动剂与骨关节炎
IF 96.2 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-10-31 DOI: 10.1056/NEJMe2409972
David T Felson
{"title":"Glucagon-Like Peptide-1 Receptor Agonists and Osteoarthritis.","authors":"David T Felson","doi":"10.1056/NEJMe2409972","DOIUrl":"https://doi.org/10.1056/NEJMe2409972","url":null,"abstract":"","PeriodicalId":54725,"journal":{"name":"New England Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":96.2,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142548979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
New England Journal of Medicine
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1