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Rehabilitation of hemianopia and visuospatial hemineglect with a mixed intervention including adapted boxing therapy: An exploratory case study. 采用包括适应性拳击疗法在内的混合干预方法,对偏盲和视觉空间偏盲进行康复治疗:一项探索性案例研究。
IF 1.7 3区 心理学 Q4 NEUROSCIENCES Pub Date : 2025-01-01 Epub Date: 2024-03-20 DOI: 10.1080/09602011.2024.2329379
Louis Nahum, Radek Ptak

Visual field loss and visuospatial neglect are frequent consequences of cerebral stroke. They often have a strong impact on independence in many daily activities. Rehabilitation aiming to decrease these disabilities is therefore important, and several techniques have been proposed to foster awareness, compensation, or restitution of the impaired visual field. We here describe a rehabilitation intervention using adapted boxing therapy that was part of a pluridisciplinary intervention tailored for a particular case. A 58-year-old man with left homonymous hemianopia (HH) and mild visuospatial hemineglect participated in 36 sessions of boxing therapy six months after a right temporo-occipital stroke. Repeated stimulation of his blind and neglected hemifield, and training to compensate for his deficits through improved use of his healthy hemifield were performed through boxing exercises. The patient showed a stable HH before the beginning of the training. After six months of boxing therapy, he reported improved awareness of his visual environment. Critically, his HH had evolved to a left superior quadrantanopia and spatial attention for left-sided stimuli had improved. Several cognitive functions and his mood also showed improvement. We conclude that boxing therapy has the potential to improve the compensation of visuospatial impairments in individual patients with visual field loss.

视野缺失和视觉空间忽略是脑卒中的常见后果。它们通常会严重影响许多日常活动的独立性。因此,旨在减少这些残疾的康复治疗非常重要,目前已提出了几种技术来促进对受损视野的认识、补偿或恢复。我们在此介绍一种采用适应性拳击疗法的康复干预方法,该方法是针对一个特殊病例量身定制的多学科干预方法的一部分。一名 58 岁的男子患有左侧同形偏盲(HH)和轻度视觉空间偏盲,在右侧颞枕叶中风 6 个月后参加了 36 次拳击治疗。通过拳击练习,反复刺激其失明和被忽视的半球,并通过改善健康半球的使用来弥补其缺陷。训练开始前,患者的 HH 显示稳定。经过 6 个月的拳击治疗后,他对视觉环境的感知有所改善。重要的是,他的 HH 已演变为左上象限失明,对左侧刺激的空间注意力也有所改善。他的一些认知功能和情绪也有所改善。我们的结论是,拳击疗法有可能改善个别视野缺损患者的视觉空间障碍补偿。
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引用次数: 0
Valued living after mild traumatic brain injury: Characteristics and relationship with outcomes. 轻度脑外伤后的有价值生活:特点及其与结果的关系。
IF 1.7 3区 心理学 Q4 NEUROSCIENCES Pub Date : 2025-01-01 Epub Date: 2024-03-18 DOI: 10.1080/09602011.2024.2328876
Josh W Faulkner, Diane Whiting, Alice Theadom, Deborah L Snell, Maree Roche, Suzanne Barker-Collo

Psychological factors are strong predictors of mild traumatic brain injury (mTBI) recovery, consequently, psychological interventions can form part of an individual's rehabilitation. This may include enhancing valued living (VL), an approach that is effective in severe and mixed acquired brain injury samples. This study aimed to characterize VL in mTBI and explore its relationship with mTBI and mental health outcomes. 56 participants with a mTBI completed self-report measures before engaging in a psychological intervention. Pre-injury mental health and other demographic and injury-related variables, VL, post-concussion symptoms (PCS), functional disability, and stress, anxiety and depression were measured. A pre-injury mental health condition was significantly associated with VL. VL was uniquely associated with depression after mTBI (β = -0.08, p = .05), however, there was no relationship with PCS, functional disability, stress or anxiety (p > .05). Following mTBI individuals with a pre-injury mental health condition or who experience heightened depressive symptoms may benefit from a values-based intervention as part of their rehabilitation. Future research, however, is needed to examine the role of VL in mTBI recovery.

心理因素是轻度创伤性脑损伤(mTBI)康复的有力预测因素,因此,心理干预可以成为个人康复的一部分。这可能包括提高有价值的生活(VL),这种方法在严重和混合型后天性脑损伤样本中很有效。本研究旨在描述 mTBI 中的 VL 特征,并探讨其与 mTBI 和心理健康结果之间的关系。56 名患有 mTBI 的参与者在接受心理干预前完成了自我报告测量。对受伤前的心理健康及其他人口统计学和受伤相关变量、VL、脑震荡后症状(PCS)、功能性残疾以及压力、焦虑和抑郁进行了测量。受伤前的心理健康状况与 VL 有显著相关性。VL 与 mTBI 后的抑郁独特相关(β = -0.08,p = .05),但与 PCS、功能性残疾、压力或焦虑没有关系(p > .05)。创伤后创伤性脑损伤后,伤前有心理健康问题或抑郁症状加重的人可能会从以价值观为基础的干预中受益,这也是他们康复的一部分。然而,未来的研究还需要对价值观念在创伤性脑损伤康复中的作用进行研究。
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引用次数: 0
Social support after TBI: an investigation of Facebook posts in open access support groups. 脑外伤后的社会支持:对开放获取支持小组中Facebook帖子的调查。
IF 1.7 3区 心理学 Q4 NEUROSCIENCES Pub Date : 2024-12-24 DOI: 10.1080/09602011.2024.2442583
Nicole Cruse, Helena Sabo, Melissa Brunner

Traumatic Brain Injury (TBI) significantly affects social interactions and emotional well-being. Following COVID-19, there has been growing interest in how individuals with TBI use online social media groups for support. This study examined engagement patterns in four Facebook support groups: two for TBI and two control groups. A deductive approach was used to categorize 4,133 posts and comments into a framework of support discourse, including seeking and giving support, and non-social support. Each category was further subdivided to analyze post content in more detail. Comments on posts were coded for helpfulness/appropriateness. Results revealed that posts in all groups fell into the identified discourse categories, with comments generally being appropriate. Minor differences were noted between TBI and control groups, suggesting that individuals with TBI engage in online support similarly to others. These findings highlight the role of online support groups for individuals with TBI, offering insights that can guide the development of more tailored interventions and improve support services for this population.

创伤性脑损伤(TBI)显著影响社会交往和情绪健康。继2019冠状病毒病之后,人们越来越关注脑外伤患者如何利用在线社交媒体群寻求支持。这项研究调查了四个Facebook支持小组的参与模式:两个是TBI小组,两个是对照组。采用演绎方法将4133篇帖子和评论分类为支持话语框架,包括寻求和给予支持以及非社会支持。每个类别进一步细分,以更详细地分析帖子内容。对帖子的评论根据有用性/适当性进行编码。结果显示,所有组的帖子都属于确定的话语类别,评论通常是适当的。在TBI组和对照组之间发现了细微的差异,这表明TBI患者的在线支持与其他人相似。这些发现强调了在线支持小组对TBI患者的作用,提供了可以指导更有针对性的干预措施的发展和改善对这一人群的支持服务的见解。
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引用次数: 0
What psychological interventions are effective for individuals with prolonged post-concussion symptoms of at least 12 months following mild traumatic brain injury? A systematic review. 哪些心理干预措施对轻度脑外伤后脑震荡症状持续至少 12 个月的患者有效?系统综述。
IF 1.7 3区 心理学 Q4 NEUROSCIENCES Pub Date : 2024-12-16 DOI: 10.1080/09602011.2024.2435283
Adele Smith, Nigel S King, Neil Carrigan, Natasha Reed

For some, post-concussion symptoms following a mild traumatic brain injury (mTBI) are prolonged in nature, lasting for a minimum of 12 months and up to many years. There remains limited insight into the effectiveness of psychological interventions for the treatment of prolonged post-concussion symptoms (PrPCS). This systematic review aimed to evaluate the effectiveness of psychological interventions for PrPCS (>12 months post mTBI). A search was performed across five databases (PsychINFO, Medline, Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL), & PubMed). Two independent researchers assessed the studies against pre-defined eligibility criteria and completed quality appraisals. Ten studies were included in the review and underwent narrative synthesis. Four psychological interventions for PrPCS were found (i.e., Cognitive Behavioural Therapy (CBT), Neurofeedback Therapy, Psychoeducation, & Mindfulness-based therapy). Emerging empirical data tends to support the assertion that psychological interventions can improve PrPCS and quality of life. CBT appears to have the strongest evidence base to date and to be the most effective in improving anxiety, anger, and overall mental well-being. However, the evidence base is still very much in its infancy and requires research with more robust methodological designs to be conducted before any conclusions can be reliably asserted.

对于某些人来说,轻度脑外伤(mTBI)后的脑震荡症状会持续很长时间,最少持续 12 个月,最长可达数年。目前,人们对心理干预治疗长期脑震荡后症状(PrPCS)的有效性了解仍然有限。本系统性综述旨在评估心理干预对 PrPCS(创伤后超过 12 个月)的有效性。我们在五个数据库(PsychINFO、Medline、Web of Science、Cumulative Index to Nursing and Allied Health Literature (CINAHL)、PubMed)中进行了检索。两名独立研究人员根据预先设定的资格标准对研究进行了评估,并完成了质量鉴定。十项研究被纳入综述并进行了叙述性综合。研究发现了四种针对 PrPCS 的心理干预方法(即认知行为疗法 (CBT)、神经反馈疗法、心理教育和正念疗法)。新出现的经验数据倾向于支持心理干预可以改善 PrPCS 和生活质量的说法。到目前为止,CBT 似乎拥有最坚实的证据基础,在改善焦虑、愤怒和整体心理健康方面也最为有效。然而,证据基础在很大程度上仍处于起步阶段,需要采用更可靠的方法设计进行研究,才能得出可靠的结论。
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引用次数: 0
Exploring the potential of Braingame Brian for executive function improvement in Spanish-speaking children with ADHD: A pilot study. 探索大脑游戏布莱恩对西班牙语多动症儿童执行功能改善的潜力:一项试点研究。
IF 1.7 3区 心理学 Q4 NEUROSCIENCES Pub Date : 2024-12-16 DOI: 10.1080/09602011.2024.2439614
Nelly Revollo Carrillo, Karol Gutiérrez-Ruiz, Tania Iglesias Rodríguez, Soraya Lewis Harb

Considering the implications of executive function (EF) in the core symptoms of attention deficit hyperactivity disorder (ADHD), further research is required on strategies such as therapies, treatments, and rehabilitation programs focused on improving EF. This study aimed to assess the potential of an EF training program called "Braingame Brian" in improving working memory, inhibition, and cognitive flexibility in children with ADHD. The programme was developed in the Netherlands and has been shown to be effective in pilot studies of ADHD populations conducted in this country. However, it has not been used before in the Spanish-speaking population. A total of 41 children (aged 8-12 years) were assigned to the EF training or waitlist control groups. The intervention consisted of a 25-session training programme of approximately 45 min per day for nine consecutive weeks. Treatment outcomes were assessed using cognitive tasks of the trained EF, as well as evaluations of EF behaviors by parents and teachers. The initial findings suggest that the implementation of the Braingame Brian programme may be associated with improvements in working memory, inhibition, and cognitive flexibility. These preliminary results also indicate the potential for enhancements in parents' and teachers' perceptions of EF difficulties in children with ADHD.

考虑到执行功能(EF)对注意力缺陷多动障碍(ADHD)核心症状的影响,需要对侧重于改善执行功能的疗法、治疗和康复计划等策略进行进一步研究。本研究旨在评估一项名为 "Braingame Brian "的EF训练计划在改善多动症儿童的工作记忆、抑制能力和认知灵活性方面的潜力。该项目由荷兰开发,在该国进行的针对多动症人群的试点研究中已被证明是有效的。不过,该方案以前从未在西班牙语人群中使用过。共有 41 名儿童(8-12 岁)被分配到 EF 训练组或候补对照组。干预措施包括连续九周、共 25 节、每天约 45 分钟的训练课程。治疗结果通过受训幼儿的认知任务以及家长和教师对幼儿行为的评价进行评估。初步研究结果表明,布赖恩-布莱恩计划的实施可能与工作记忆、抑制和认知灵活性的改善有关。这些初步结果还表明,家长和教师对多动症儿童的 EF 困难的看法有可能得到改善。
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引用次数: 0
After the buzzer sounds: Adults unveil the consequences of concussions sustained during adolescence. 蜂鸣器响起后:成年人揭开青少年时期脑震荡的后果。
IF 1.7 3区 心理学 Q4 NEUROSCIENCES Pub Date : 2024-12-16 DOI: 10.1080/09602011.2024.2439332
Heather A Shepherd, Meghan L Critchley, Carolyn A Emery, Jeffrey G Caron

Concussions are commonly occurring injuries in sport. The short-term impacts of concussions, including symptoms and recovery trajectories, often are the focus of concussion research. However, limited studies have explored the long-term consequences of concussions, especially in adolescents. The purpose of this study was to explore adults' experiences with concussions sustained during their adolescence (5-15 years prior). This qualitative study was guided by an interpretivist philosophy. Twenty young adults (11 men, 9 women, median age 26) who had sustained at least one sport-related concussion during their adolescence participated in a one-on-one semi-structured interview. We aimed to explore their experiences with their concussion at the time of injury and any consequences they experienced as a result of their concussion. We organized participants' concussion experiences into six main themes: (1) Concussion diagnosis and experiences with health care providers; (2) Emotional symptoms following concussion; (3) Concussion recovery; (4) Change in sport participation and engagement; (5) Concern about the potential long-term consequences; and (6) Impact on social relationships. We used the Biopsychosocial Model of Sport Injury Rehabilitation to organize the themes. Future research should explore how acute multi-disciplinary support could reduce the negative long-term consequences of concussion in adolescents.

脑震荡是体育运动中常见的损伤。脑震荡的短期影响,包括症状和恢复轨迹,往往是脑震荡研究的重点。然而,对脑震荡的长期后果,尤其是对青少年脑震荡的长期后果的研究却十分有限。本研究旨在探讨成年人在青春期(5-15 年前)遭受脑震荡的经历。这项定性研究以解释主义哲学为指导。20 名在青春期至少遭受过一次运动相关脑震荡的年轻人(11 名男性,9 名女性,中位年龄 26 岁)参加了一对一的半结构化访谈。我们的目的是探究他们受伤时的脑震荡经历,以及他们因脑震荡而经历的任何后果。我们将参与者的脑震荡经历分为六大主题:(1) 脑震荡诊断和与医疗服务提供者的经历;(2) 脑震荡后的情绪症状;(3) 脑震荡恢复;(4) 运动参与和投入的变化;(5) 对潜在长期后果的担忧;以及 (6) 对社会关系的影响。我们使用运动损伤康复的生物心理社会模型来组织这些主题。未来的研究应探索如何通过急性多学科支持来减少青少年脑震荡的长期负面影响。
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引用次数: 0
A qualitative study investigating the views of stroke survivors and their family members on discussing post-stroke cognitive trajectories. 一项定性研究,调查中风幸存者及其家人对讨论中风后认知轨迹的看法。
IF 1.7 3区 心理学 Q4 NEUROSCIENCES Pub Date : 2024-12-01 Epub Date: 2024-02-17 DOI: 10.1080/09602011.2024.2314882
Georgina Hobden, Eugene Yee Hing Tang, Nele Demeyere

Cognitive impairment is common early after stroke but trajectories over the long term are variable. Some stroke survivors make a full recovery, while others retain a stable impairment or decline. This study explored the perceived advantages and disadvantages of discussing potential cognitive trajectories with stroke survivors and their family members. Stroke survivors at least six-months post-stroke were purposively sampled from an existing pool of research volunteers recruited originally for the OCS-Recovery study. They were invited, alongside a family member, to participate in a semi-structured interview. Interviews were audio recorded, transcribed, and analyzed using reflexive thematic analysis. Twenty-six stroke survivors and eleven family members participated. We identified one overarching theme and three related subthemes. The overarching theme was: One size does not fit all. The subthemes were: (1) Hearing about potential cognitive trajectories helps to develop realistic expectations; (2) Discussions about cognitive trajectories may be motivating; (3) Cognitive decline and post-stroke dementia discussions may be anxiety-provoking and depressing. Healthcare professionals should adopt a person-centred approach to sharing information about post-stroke cognitive trajectories. Discussions should be tailored to individual needs and preferences, with dementia-related topics in particular addressed with the utmost selectivity and sensitivity.

认知功能障碍在中风后早期很常见,但长期的发展轨迹却各不相同。一些中风幸存者完全康复,而另一些则保持稳定的损伤或衰退。本研究探讨了与中风幸存者及其家人讨论潜在认知轨迹的利弊。研究人员从现有的研究志愿者库中有目的地抽取了中风后至少六个月的幸存者,这些志愿者最初是为 OCS-Recovery 研究而招募的。他们与一名家庭成员一起被邀请参加半结构化访谈。访谈进行了录音、转录,并使用反思性主题分析法进行了分析。共有 26 名中风幸存者和 11 名家属参加了访谈。我们确定了一个总体主题和三个相关次主题。总主题是不能一刀切。次主题是(1) 了解潜在的认知轨迹有助于形成现实的期望;(2) 关于认知轨迹的讨论可能具有激励作用;(3) 关于认知衰退和中风后痴呆的讨论可能会令人焦虑和沮丧。医护人员在分享有关卒中后认知轨迹的信息时,应采取以人为本的方法。讨论应根据个人的需要和偏好进行,尤其是与痴呆相关的话题,要有最大的选择性和敏感性。
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引用次数: 0
"Communicative competence assessment of the person with aphasia caregiver: Standardization of the ACCA-CHECKLIST". "失语症患者护理人员的沟通能力评估:ACCA-CHECKLIST 标准化"。
IF 1.7 3区 心理学 Q4 NEUROSCIENCES Pub Date : 2024-12-01 Epub Date: 2024-03-05 DOI: 10.1080/09602011.2024.2315772
Giada Bartolini, Lara Laschi, Francesca Dorgali, Laura Abbruzzese, Alessio Damora, Alessandra Stocchi, Maria Assunta Saieva, Fabio Ferretti, Lucia Ferroni, Costanza Papagno, Alessandra Caporali, Giuseppe Mancini, Mauro Mancuso

Aphasia constitutes a very complex clinical entity that requires a "competent" caregiver to interact with the person with aphasia (PWA). The literature lacks a valid and reliable set of standardized tools which can offer objective and quantifiable data of a caregiver's communicative competence. The aim of the study was to develop, standardize and validate an evaluation tool suited to measur the caregivers' competence in communicating with family members affected by aphasic disorders. Forty-two patients with aphasia and their respective caregivers were enrolled in the study. Caregivers' communicative competence was assessed through a new evaluation tool called ACCA-cl. Aphasia severity and functional communication abilities of the PWA were also investigated. Our data showed encouraging results regarding the reliability and the validity of the ACCA-cl scale in detecting the caregiver's communicative competence, especially as far as verbal content was considered. This scale can also be used to assess the improvement achieved by the caregiver after a communication training. The analysis provides encouraging findings for verbal content scales of the ACCA-cl and its possible use in clinical settings as a quantitative tool for detecting changes induced by the educational method of the caregiver. The tool is currently available in Italian.

失语症是一种非常复杂的临床症状,需要 "称职 "的护理人员与失语症患者(PWA)进行交流。文献中缺乏一套有效、可靠的标准化工具,能够提供客观、可量化的数据来衡量照顾者的沟通能力。本研究的目的是开发、标准化并验证一种评估工具,用于测量照顾者与受失语症影响的家庭成员沟通的能力。研究共招募了 42 名失语症患者及其照顾者。照顾者的沟通能力通过一种名为 ACCA-cl 的新评估工具进行评估。此外,还对 PWA 的失语严重程度和功能性交流能力进行了调查。我们的数据显示,ACCA-cl 量表在检测照顾者的沟通能力方面,尤其是在语言内容方面,具有令人鼓舞的可靠性和有效性。该量表还可用于评估护理人员在接受沟通培训后所取得的进步。这项分析为 ACCA-cl 的言语内容量表提供了令人鼓舞的结果,并可将其作为一种定量工具用于临床环境,以检测护理人员的教育方法所引起的变化。该工具目前有意大利语版本。
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引用次数: 0
Cognitive remediation in residential substance use treatment: A randomized stepped-wedge trial. 住院药物使用治疗中的认知矫正:阶梯式随机试验
IF 1.7 3区 心理学 Q4 NEUROSCIENCES Pub Date : 2024-12-01 Epub Date: 2024-02-15 DOI: 10.1080/09602011.2024.2314879
Talia Nardo, Jamie Berry, Daniel Barker, Hassan Assareh, Jo Lunn, Antoinette Sedwell, Jennifer Batchelor, Anthony Shakeshaft, Peter J Kelly, Pooria Sarrami, Skye Russell, Megan James

ABSTRACTExecutive dysfunction is common in individuals with substance use disorder (SUD) and presents a barrier to treatment engagement. The study aimed to investigate the effectiveness of cognitive remediation (CR) for improving executive functioning and treatment retention in patients with SUD, using a stepped-wedge cluster randomized controlled trial. The sample included 527 adults enrolled across ten residential SUD treatment providers in NSW, Australia. The intervention consisted of 12 hours of CR delivered over six weeks in a group format. The comparator was treatment-as-usual (TAU). Primary outcomes included self-reported executive functioning and proportion of treatment completed (PoTC), measured as the number of days in treatment divided by the planned treatment duration. Intention-to-treat analysis did not find significant differences for self-reported executive functioning (mean difference = -2.49, 95%CI [-5.07, 0.09], p = .059) or PoTC (adjusted mean ratio = 1.09, 95%CI [0.88, 1.36], p = .442). Due to high dropout from the intention-to-treat sample (56%) a post-hoc analysis was conducted using a per-protocol approach, in which CR was associated with improved self-reported executive functioning (mean difference = -3.33, 95%CI [-6.10, -0.57], p = .019) and improved likelihood of treatment graduation (adjusted odds ratio = 2.43, 95%CI [1.43, 4.11], p < .001). More research is required to develop a CR approach that results in service-wide treatment effectiveness.

摘要执行功能障碍在药物使用障碍(SUD)患者中很常见,是参与治疗的一个障碍。本研究采用阶梯式群组随机对照试验,旨在调查认知矫正(CR)对改善药物滥用障碍患者的执行功能和治疗保持率的有效性。样本包括在澳大利亚新南威尔士州十家药物滥用住院治疗机构接受治疗的 527 名成人。干预措施包括在六周内以小组形式进行 12 小时的 CR 治疗。对照组为常规治疗(TAU)。主要结果包括自我报告的执行功能和完成治疗的比例(PoTC),以治疗天数除以计划治疗时间来衡量。意向治疗分析未发现自我报告的执行功能(平均差异 = -2.49,95%CI [-5.07, 0.09],p = .059)或 PoTC(调整后平均比率 = 1.09,95%CI [0.88, 1.36],p = .442)有显著差异。由于意向治疗样本的高辍学率(56%),我们采用按协议方法进行了事后分析,结果显示 CR 与自我报告的执行功能改善有关(平均差 = -3.33,95%CI [-6.10, -0.57],p = .019),与治疗毕业的可能性改善有关(调整后的几率比 = 2.43,95%CI [1.43, 4.11],p = .059)。
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引用次数: 0
Comparing high definition transcranial direct current stimulation to left temporoparietal junction and left inferior frontal gyrus for logopenic primary progressive aphasia: A single-case study. 比较高清经颅直流电刺激左侧颞顶叶交界处和左侧额叶下回治疗对数开放性原发性进行性失语症:一项单例研究。
IF 1.7 3区 心理学 Q4 NEUROSCIENCES Pub Date : 2024-12-01 Epub Date: 2024-02-15 DOI: 10.1080/09602011.2024.2314878
Samuel J Crowley, Alexandru D Iordan, Kayla Rinna, Sami Barmada, Benjamin M Hampstead

Logopenic variant primary progressive aphasia (lvPPA) is characterized by word-finding deficits and phonologic errors in fluent speech. Transcranial direct current stimulation (tDCS) targeting either left temporoparietal junction (TPJ) or left inferior frontal gyrus (IFG) show evidence of improving language function in lvPPA. The present case study evaluated the effects of two separate rounds of high definition tDCS (HD-tDCS) (4 mA; 30 sessions) on language and functional neuroimaging in a 57-year-old woman with lvPPA. Stimulation was centred on two different regions across rounds: (1) left TPJ, and (2) left (IFG). Results showed an improved proportion of content to floorholder words during a naturalistic speech task through both rounds as well as change in confrontation naming after TPJ (improvement) and IFG (worsened) stimulation. fMRI connectivity during task showed left lateralized positive correlations following round 1 and anti-correlations with components of the default mode network following round 2. Resting state segregation of a language-associated functional network increased following both rounds, and task-based segregation of the same network increased following IFG stimulation. These results suggest that stimulation to both regions using HD-tDCS may improve language function in lvPPA, while simultaneously eliciting widespread changes beyond the targeted area in neuronal activity and functional connectivity.

对数变异型原发性进行性失语症(lvPPA)的特点是在流利言语中出现找词障碍和语音错误。有证据表明,针对左侧颞顶叶交界处(TPJ)或左侧额叶下回(IFG)的经颅直流电刺激(tDCS)可改善lvPPA患者的语言功能。本病例研究评估了两轮独立的高清 tDCS(HD-tDCS)(4 mA;30 次治疗)对一名 57 岁女性 lvPPA 患者的语言和功能神经影像学的影响。两轮刺激分别以两个不同区域为中心:(1) 左侧 TPJ,(2) 左侧(IFG)。结果显示,在自然言语任务中,两轮刺激后内容词与底层词的比例均有所改善,TPJ(改善)和 IFG(恶化)刺激后对抗命名也发生了变化。任务期间的 fMRI 连接显示,第一轮刺激后出现左侧正相关,第二轮刺激后出现与默认模式网络成分的反相关。在两轮刺激后,语言相关功能网络的静息状态分离增加,而在刺激 IFG 后,同一网络的任务分离增加。这些结果表明,使用HD-tDCS刺激这两个区域可以改善lvPPA患者的语言功能,同时在神经元活动和功能连接方面引起目标区域以外的广泛变化。
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引用次数: 0
期刊
Neuropsychological Rehabilitation
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