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Orthopedic trauma in pregnancy: A literature review 妊娠期骨科创伤:文献综述
IF 2 3区 医学 Q3 CRITICAL CARE MEDICINE Pub Date : 2025-12-11 DOI: 10.1016/j.injury.2025.112969
William H. Fang , Vitaley Kovalev , Theresa Pak
Orthopedic injuries during pregnancy pose unique risks to maternal and fetal health. This review identifies different epidemiological data, maternal physiological changes, imaging considerations, pain management strategies, and operative considerations. Motor vehicle accidents, falls, and domestic violence contribute to fractures, emphasizing the need for tailored management. Special attention is given to imaging modalities, with a focus on fetal safety. Pain management strategies balance effective analgesia with fetal well-being, emphasizing the cautious use of opioids. Perioperative fetal monitoring and anticoagulation considerations address the intricacies of managing orthopedic injuries during pregnancy. Prevention strategies, such as promoting seat belt use and intimate partner violence screening, are crucial for minimizing risks. This concise review serves as a comprehensive guide for healthcare professionals managing orthopedic injuries in pregnant patients.
妊娠期骨科损伤对孕产妇和胎儿健康构成独特的风险。本综述确定了不同的流行病学资料、产妇生理变化、影像学考虑、疼痛管理策略和手术考虑。机动车事故、跌倒和家庭暴力都是造成骨折的原因,因此需要针对性的治疗。特别注意的是成像方式,重点是胎儿安全。疼痛管理策略平衡有效的镇痛与胎儿的健康,强调谨慎使用阿片类药物。围手术期胎儿监测和抗凝注意事项解决了妊娠期间骨科损伤管理的复杂性。预防战略,如促进安全带的使用和亲密伴侣暴力筛查,对于最大限度地减少风险至关重要。这篇简明的综述为医疗保健专业人员管理妊娠患者骨科损伤提供了全面的指导。
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引用次数: 0
Predicting anxiety, depression, PTSD and psychotic disorders after traumatic brain injury in civilian adults: A systematic review of multivariable prognostic models 预测平民成人创伤性脑损伤后的焦虑、抑郁、创伤后应激障碍和精神障碍:多变量预后模型的系统回顾
IF 2 3区 医学 Q3 CRITICAL CARE MEDICINE Pub Date : 2025-12-11 DOI: 10.1016/j.injury.2025.112959
John Perera , Sue Patterson , Natalie Barker , Dylan Flaws , Zemedu Ferede

Background

Psychiatric disorders are common after traumatic brain injury, impeding recovery and increasing health and social costs internationally. clinicians caring for patients with TBI need an evidence base to support assessment of risk of and intervention to reduce psychiatric morbidity.

Method

We systematically searched for original studies published in English reporting development of multivariate models predicting anxiety, depression, PTSD and psychotic disorders in civilian adults at least six months after injury. The electronic search was conducted on 12 August 2024. Authors independently screened records, assessed study quality, and extracted data for descriptive analysis and narrative synthesis.

Results

We included 34 studies presenting 47 multivariable models predicting psychiatric disorder six to 120 months after TBI of varying severity. Study samples, ranging from 43 to 207,354, were predominantly male and Caucasian/White and aged 30–45 years. Models inconsistently included demographic, psychosocial and injury-related variables with mixed results. Female sex, psychiatric history, race/ethnicity, physical health and assault/violent mechanism of injury were statistically significant two-thirds of models in which they were included. Infrequently included variables including coping style and intoxication at injury were strongly associated with disorder.

Discussion

Faced with inconsistency in evidence we recommend that clinicians assess risk of suboptimal outcome broadly, asking not whether a given patient is at risk of a specific psychiatric condition but of any psychiatric disturbance following TBI. Patients with a psychiatric history and/or injured violently should be monitored but assessment must encompass biopsychosocial circumstances. Employment of a conceptual model of psychiatric disorder would support development of a cohesive evidence base.
背景:精神障碍是颅脑外伤后常见的疾病,在国际上阻碍了康复并增加了健康和社会成本。治疗TBI患者的临床医生需要一个证据基础来支持风险评估和降低精神疾病发病率的干预措施。方法:我们系统地检索了英文发表的原始研究,这些研究报告了多变量模型的发展,预测了受伤后至少六个月的平民成人的焦虑、抑郁、创伤后应激障碍和精神障碍。电子搜查于2024年8月12日进行。作者独立筛选记录,评估研究质量,并提取数据进行描述性分析和叙事综合。结果:我们纳入了34项研究,其中包括47个多变量模型,预测不同严重程度的创伤性脑损伤后6至120个月的精神障碍。研究样本范围从43到207,354,主要是男性和高加索/白人,年龄在30-45岁之间。模型不一致地包括人口统计、社会心理和伤害相关变量,结果好坏参半。女性性别、精神病史、种族/民族、身体健康和攻击/暴力伤害机制在统计上具有显著意义,占纳入这些因素的模型的三分之二。不常见的变量包括应对方式和受伤时的中毒与障碍密切相关。讨论:面对证据的不一致,我们建议临床医生广泛评估次优结果的风险,不询问给定患者是否有特定精神疾病的风险,而是询问创伤性脑损伤后是否有任何精神障碍。有精神病史和/或暴力伤害的患者应进行监测,但评估必须包括生物心理社会环境。采用精神障碍的概念模型将有助于建立一个有凝聚力的证据基础。
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引用次数: 0
Management of Cervical lateral mass fractures –A systematic review 颈椎侧块骨折的治疗——系统综述。
IF 2 3区 医学 Q3 CRITICAL CARE MEDICINE Pub Date : 2025-12-11 DOI: 10.1016/j.injury.2025.112962
Kevin Yoon , Amanuel Ayano , Gonzalo F. Del Rio Montesinos , Linus Lee , Jonathan P. Japa , Mark Ehioghae , Addisu Mesfin

Introduction

A notable anatomic feature of the facet joint is the lateral mass, which is comprised of the superior and inferior articular processes of the vertebral body. A unique fracture pattern involves a lamina fracture and ipsilateral pedicle fracture resulting in a separation of the lateral mass from the vertebral body, called a floating lateral mass fracture (FLM). FLMs commonly co-occur with vertebral artery or neurologic injury and is usually managed surgically. Few studies have focused on FLMs alone; thus, the objective of the current study is to provide a systematic review regarding the epidemiology and management of FLM.

Methods

A retrospective protocol was used to search Medline (via PubMed) and Embase to identify all studies focused on floating lateral mass fractures. “floating lateral mass fracture” and “cervical” or “spine” were used in conjunction with boolean terms to find related articles. Single-case studies, unpublished articles, non-English articles, and other systematic reviews were excluded. Studies focusing on C1 lateral mass fractures were also excluded. Data regarding patient characteristics, injury characteristics, diagnostic imaging, and treatment were gathered.

Result

A total of 332 patients were identified with floating lateral mass fractures (FLM) of the subaxial cervical spine. There were 217 men (63.4 %) and 68 women (20.5 %) and 47 participants with gender not reported. The mean age was 41.8 ± 7.98 years. The most common levels of injury C6 and C5. Motor vehicle accidents (MVAs) were the most reported index event. Cervical collars were the most used non-operative treatment modality, with most studies specifying the use of hard cervical collar or a halo vest. Vertebral subluxation was later identified in 22 (31 %) patients treated nonoperatively. Anterior cervical discectomy and fusion (ACDF) was the most performed procedure including a one level, with 67 patients (28.2 %) and two-level fusions with 55 patients (23.2 %), totaling to 122 patients (51.4 %). Minimal reports of subluxation post-operatively were reported.

Conclusion

Floating lateral mass fractures are an uncommon, but severe, subtype of cervical facet fractures. FLM inherently results in spinal instability, and as a result surgical management is preferred versus non-surgical.
小关节的一个显著解剖特征是侧块,它由椎体的上、下关节突组成。一种独特的骨折类型包括椎板骨折和同侧椎弓根骨折,导致侧块从椎体分离,称为浮动侧块骨折(FLM)。FLMs通常与椎动脉或神经损伤同时发生,通常采用手术治疗。很少有研究只关注flm;因此,本研究的目的是对FLM的流行病学和管理进行系统的综述。方法:采用回顾性方案检索Medline(通过PubMed)和Embase,以确定所有关注漂浮侧块性骨折的研究。“漂浮侧块骨折”和“颈椎”或“脊柱”与布尔术语结合使用来查找相关文章。排除了单例研究、未发表文章、非英文文章和其他系统综述。C1侧块骨折的研究也被排除在外。收集有关患者特征、损伤特征、诊断影像和治疗的数据。结果:共有332例患者被确定为颈椎下轴位漂浮性侧块骨折(FLM)。217名男性(63.4%),68名女性(20.5%),47名性别未报告。平均年龄41.8±7.98岁。最常见的损伤级别是C6和C5。机动车事故(MVAs)是报告最多的指数事件。颈套是最常用的非手术治疗方式,大多数研究指定使用硬颈套或光环背心。22例(31%)非手术治疗后发现椎体半脱位。前路颈椎椎间盘切除术融合(ACDF)是最多的手术,包括67例(28.2%)单节段融合和55例(23.2%)双节段融合,共计122例(51.4%)。极少报告术后半脱位。结论:漂浮侧块骨折是一种少见但严重的颈椎小关节骨折亚型。FLM固有地导致脊柱不稳定,因此手术治疗优于非手术治疗。
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引用次数: 0
The impact and burden of spinal fractures in a small island state: Pre-, acute, and post-COVID-19 trends from Malta 小岛屿国家脊柱骨折的影响和负担:马耳他的covid -19前、急性和后趋势
IF 2 3区 医学 Q3 CRITICAL CARE MEDICINE Pub Date : 2025-12-10 DOI: 10.1016/j.injury.2025.112950
Stephan Grech , Andrea Cuschieri , Franziska Mintoff , Darryl Pisani , Sarah Cuschieri

Background

Spinal fractures represent a significant cause of morbidity, requiring both acute and long-term care. Data on their epidemiology in small state settings are limited. This study aimed to describe the population burden, clinical characteristics, and healthcare impact of spinal fractures in Malta over a five-year period.

Methods

A retrospective analysis was conducted using the Hospital Activity Analysis (HAA) database of Mater Dei Hospital, Malta, between 2019 and 2024. Data included demographics, fracture type (ICD-10), length of stay (LOS), admission and discharge source, mechanism of injury, need for intensive care unit (ITU) admission, spinal cord injury, and co-morbidities. Fracture types were grouped as cervical, thoracic, lumbar single-level, or multi-level fractures. Descriptive statistics, chi-square, t-tests, and logistic regression were applied, with p<0.05 considered significant.

Results

A total of 640 spinal fractures were recorded (56% males, 44% females). Lumbar single-level fractures were most common (38%), followed by multi-level fractures (30%). Falls were the predominant mechanism (53%). While 90% were admitted directly from home, only 70% were discharged home, with 16% requiring transfer to rehabilitation. The longest LOS was for cervical single-level fractures (15.7 days, p=0.019). ITU admission was uncommon (4%), predominantly in multi-level fractures, which also had the highest spinal cord injury prevalence (36%). Co-morbidities were frequent (71%), particularly cardiovascular disease (49%). Logistic regression showed multimorbidity was positively associated with single-level fractures (OR 1.66, 95% CI: 1.04–2.67, p=0.035).

Conclusions

Spinal fractures in Malta impose a substantial burden, extending beyond acute care into rehabilitation. Falls were the leading cause, and multimorbidity significantly influenced fracture patterns. These findings underscore the need for integrated fall-prevention strategies, chronic disease management, and strengthened rehabilitation services in small-state healthcare systems.
背景:脊柱骨折是发病率的重要原因,需要急性和长期护理。他们在小州的流行病学数据有限。本研究旨在描述马耳他五年来脊柱骨折的人口负担、临床特征和医疗保健影响。方法采用马耳他Mater Dei医院2019 - 2024年医院活动分析(HAA)数据库进行回顾性分析。数据包括人口统计学、骨折类型(ICD-10)、住院时间(LOS)、入院和出院来源、损伤机制、需要入住重症监护病房(ITU)、脊髓损伤和合并症。骨折类型分为颈椎、胸椎、腰椎单节段骨折和多节段骨折。采用描述性统计、卡方检验、t检验和逻辑回归,p<;0.05为显著性。结果本组共发生脊柱骨折640例(男56%,女44%)。腰椎单节段骨折最常见(38%),其次是多节段骨折(30%)。跌倒是主要的发病机制(53%)。90%的患者直接从家中入院,只有70%的患者出院回家,16%的患者需要转到康复中心。最长的LOS是颈椎单节段骨折(15.7天,p=0.019)。ITU入院的情况并不常见(4%),主要是多层骨折,这类骨折的脊髓损伤发生率也最高(36%)。合并症很常见(71%),尤其是心血管疾病(49%)。Logistic回归分析显示多发病与单节段骨折呈正相关(OR 1.66, 95% CI: 1.04-2.67, p=0.035)。结论脊柱骨折在马耳他造成了巨大的负担,从急性护理延伸到康复。跌倒是主要原因,多病对骨折类型有显著影响。这些发现强调了在小州医疗保健系统中需要综合预防跌倒策略、慢性病管理和加强康复服务。
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引用次数: 0
Computer-vision based recognition of cervical spine stabilization during trauma resuscitation 创伤复苏中颈椎稳定的计算机视觉识别。
IF 2 3区 医学 Q3 CRITICAL CARE MEDICINE Pub Date : 2025-12-10 DOI: 10.1016/j.injury.2025.112951
Mary S. Kim , Sifan Yuan , Genevieve J. Sippel , Aaron H. Mun , Dylan W. Arkowitz , Ivan Marsic , Randall S. Burd

Background

Cervical spine (c-spine) injuries can lead to significant disability and mortality. Although stabilization is the primary management for suspected c-spine injuries, lapses in stabilization frequently occur during trauma resuscitation. To facilitate evaluation of c-spine management, we developed a computer vision system to detect stabilization techniques. This system would enable scalable monitoring, including the timing and duration of c-spine stabilization.

Methods

We developed a 2-stage computer vision system to detect prehospital rigid c-collar, hospital semi-rigid c-collar, and manual in-line stabilization. The system was trained, tested, and validated using image frames extracted from 86 pediatric trauma resuscitation videos at a level 1 pediatric trauma center from October 2022 to May 2023. The first stage identified the patient in each image, and the second stage classified the stabilization technique. A 5-fold cross-validation was performed on the first 68 resuscitation videos for training/testing, with the latest 18 cases reserved for validation. System performance was evaluated using accuracy, precision, recall, F1 score, and Matthews correlation coefficient (MCC). To assess system potential for manual in-line detection, 10 simulation videos were added (eight for training, two for testing).

Results

In the 18 validation cases, the system achieved high accuracy for binary classification (0.91) and for detecting specific stabilization techniques: prehospital rigid c-collar (0.95), hospital semi-rigid c-collar (0.93), and manual in-line stabilization (0.97). The precision scores were 0.89 for binary classification of any stabilization method, 0.71 for prehospital rigid c-collar, 0.89 for hospital semi-rigid c-collar, and 0.04 for manual in-line. Recall, F1, and MCC scores aligned with these findings, with the highest values observed for detecting the hospital semi-rigid c-collar among the stabilization techniques. Adding simulation videos improved manual in-line stabilization detection, with accuracy 0.62, precision 0.88, recall 0.58, F1 score 0.70, and MCC 0.27.

Conclusion

The 2-stage computer vision system showed excellent performance for detecting c-spine stabilization, with limitations for manual in-line stabilization due to its rarity. Simulation data improved manual in-line detection, highlighting potential benefits of a more balanced dataset. The computer vision system may serve as a prototype for automated monitoring of trauma resuscitation using the camera infrastructure in the resuscitation room.
背景:颈椎损伤可导致严重的残疾和死亡。虽然稳定是疑似颈椎损伤的主要治疗方法,但在创伤复苏过程中,稳定失误经常发生。为了便于评估颈椎管理,我们开发了一种计算机视觉系统来检测稳定技术。该系统可实现可扩展的监测,包括颈椎稳定的时间和持续时间。方法:我们开发了一个两阶段的计算机视觉系统来检测院前刚性c型领、医院半刚性c型领和人工在线稳定。该系统使用从2022年10月至2023年5月一家一级儿科创伤中心的86个儿科创伤复苏视频中提取的图像帧进行训练、测试和验证。第一阶段在每张图像中识别患者,第二阶段对稳定技术进行分类。对前68个用于培训/测试的复苏视频进行5倍交叉验证,最后18个病例保留用于验证。系统性能评估使用准确性、精密度、召回率、F1分数和马修斯相关系数(MCC)。为了评估人工在线检测的系统潜力,增加了10个模拟视频(8个用于培训,2个用于测试)。结果:在18例验证病例中,该系统在二元分类(0.91)和特定稳定技术检测方面均取得了较高的准确性:院前刚性c-collar(0.95),医院半刚性c-collar(0.93)和手动在线稳定(0.97)。任意稳定化方法二元分类的精度得分为0.89,院前刚性c-collar的精度得分为0.71,医院半刚性c-collar的精度得分为0.89,手工直管的精度得分为0.04。回想一下,F1和MCC评分与这些发现一致,在稳定技术中,检测医院半刚性c型颈圈的得分最高。添加仿真视频后,手动在线稳定检测的准确率为0.62,精密度为0.88,召回率为0.58,F1得分为0.70,MCC为0.27。结论:两阶段计算机视觉系统在检测颈椎稳定方面表现优异,但由于其罕见,人工在线稳定存在局限性。模拟数据改进了手动在线检测,突出了更平衡的数据集的潜在好处。计算机视觉系统可以作为使用复苏室内摄像机基础设施对创伤复苏进行自动监测的原型。
{"title":"Computer-vision based recognition of cervical spine stabilization during trauma resuscitation","authors":"Mary S. Kim ,&nbsp;Sifan Yuan ,&nbsp;Genevieve J. Sippel ,&nbsp;Aaron H. Mun ,&nbsp;Dylan W. Arkowitz ,&nbsp;Ivan Marsic ,&nbsp;Randall S. Burd","doi":"10.1016/j.injury.2025.112951","DOIUrl":"10.1016/j.injury.2025.112951","url":null,"abstract":"<div><h3>Background</h3><div>Cervical spine (c-spine) injuries can lead to significant disability and mortality. Although stabilization is the primary management for suspected c-spine injuries, lapses in stabilization frequently occur during trauma resuscitation. To facilitate evaluation of c-spine management, we developed a computer vision system to detect stabilization techniques. This system would enable scalable monitoring, including the timing and duration of c-spine stabilization.</div></div><div><h3>Methods</h3><div>We developed a 2-stage computer vision system to detect prehospital rigid c-collar, hospital semi-rigid c-collar, and manual in-line stabilization. The system was trained, tested, and validated using image frames extracted from 86 pediatric trauma resuscitation videos at a level 1 pediatric trauma center from October 2022 to May 2023. The first stage identified the patient in each image, and the second stage classified the stabilization technique. A 5-fold cross-validation was performed on the first 68 resuscitation videos for training/testing, with the latest 18 cases reserved for validation. System performance was evaluated using accuracy, precision, recall, F1 score, and Matthews correlation coefficient (MCC). To assess system potential for manual in-line detection, 10 simulation videos were added (eight for training, two for testing).</div></div><div><h3>Results</h3><div>In the 18 validation cases, the system achieved high accuracy for binary classification (0.91) and for detecting specific stabilization techniques: prehospital rigid c-collar (0.95), hospital semi-rigid c-collar (0.93), and manual in-line stabilization (0.97). The precision scores were 0.89 for binary classification of any stabilization method, 0.71 for prehospital rigid c-collar, 0.89 for hospital semi-rigid c-collar, and 0.04 for manual in-line. Recall, F1, and MCC scores aligned with these findings, with the highest values observed for detecting the hospital semi-rigid c-collar among the stabilization techniques. Adding simulation videos improved manual in-line stabilization detection, with accuracy 0.62, precision 0.88, recall 0.58, F1 score 0.70, and MCC 0.27.</div></div><div><h3>Conclusion</h3><div>The 2-stage computer vision system showed excellent performance for detecting c-spine stabilization, with limitations for manual in-line stabilization due to its rarity. Simulation data improved manual in-line detection, highlighting potential benefits of a more balanced dataset. The computer vision system may serve as a prototype for automated monitoring of trauma resuscitation using the camera infrastructure in the resuscitation room.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 2","pages":"Article 112951"},"PeriodicalIF":2.0,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145770512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Occult contralateral sacroiliac joint injuries missed on single-energy CT of operative pelvis fractures 手术骨盆骨折单能量CT未发现对侧骶髂关节损伤。
IF 2 3区 医学 Q3 CRITICAL CARE MEDICINE Pub Date : 2025-12-10 DOI: 10.1016/j.injury.2025.112952
Joseph T. Patterson , Michael Allen , Vivek Satish , Andrew M. Duong , Reza Firoozabadi , Joshua L. Gary

Objective

To determine the diagnostic performance of single-energy CT (SECT) scan for detecting contralateral posterior pelvic ring injuries in patients with an operative pelvis fracture.

Methods

Retrospective cohort study.

Setting

Level I Trauma Center

Patient selection criteria

Consecutive adults with operatively-treated pelvic ring injuries and preoperative and postoperative pelvis CT scans. Exclusion criteria were incomplete or unreadable imaging, pelvis CT obtained on a spine board or with a pelvic binder in place, prior pelvic instrumentation, or sacroiliac joint fusion.

Outcome

Measures and Comparisons: An “occult” contralateral sacroiliac joint injury was defined as either (A) a positive change of ≥2.0 mm between preoperative and postoperative CT measurements at this level on the “uninjured” side or (B) an intraoperatively fluoroscopic finding of ≥2.0 mm of sacroiliac joint widening on either static or dynamic stress fluoroscopic imaging on the “uninjured” side not present on the initial, preoperative CT

Results

One hundred forty-six adults, 62 % male sex, with a mean age of 42.5 years were included. A unilateral posterior pelvic ring injury was identified on the initial pelvis CT in ninety patients. An occult contralateral sacroiliac joint injury was identified in 11 patients (12.2 %), 5 by intraoperative fluoroscopic examination, none during instrumentation, and 6 by postoperative pelvis CT. One U-type sacral fracture was identified on postoperative CT. The diagnostic performance of pelvis SECT in the initial trauma evaluation for correctly classifying bilateral pelvic ring injuries was 84 % sensitivity with a 16 % false negative rate, 100 % specificity, 88 % negative predictive value, and 92 % accuracy.

Conclusions

In this cohort, 16 % of bilateral posterior ring injuries were incorrectly classified as unilateral from the initial pelvis CT. A complete unilateral posterior ring injury should raise suspicion for an occult contralateral injury and may warrant additional radiographic or fluoroscopic stress examination if clinically appropriate.
目的:探讨单能量CT (SECT)扫描对骨盆术后骨折对侧骨盆后环损伤的诊断价值。方法:回顾性队列研究。环境:一级创伤中心患者选择标准:连续接受手术治疗的骨盆环损伤患者,术前和术后进行骨盆CT扫描。排除标准为影像学不完整或难以读懂、骨盆CT在脊柱板上或有骨盆固定物、既往骨盆内固定或骶髂关节融合。结果:测量和比较:“隐匿性”对侧骶髂关节损伤被定义为(A)术前和术后在“未损伤”侧的该水平的CT测量值之间的正变化≥2.0 mm,或(B)术中在“未损伤”侧的静态或动态应力透视成像中发现≥2.0 mm的骶髂关节增宽,而在初始术前CT上没有出现。146名成年人,62%为男性,平均年龄为42.5岁。90例患者首次骨盆CT显示单侧骨盆后环损伤。11例(12.2%)患者发现隐匿性对侧骶髂关节损伤,5例术中透视检查,器械检查中无,6例术后骨盆CT检查。术后CT发现1例u型骶骨骨折。骨盆造影在初始创伤评估中对双侧骨盆环损伤正确分类的诊断表现为84%的敏感性,16%的假阴性率,100%的特异性,88%的阴性预测值和92%的准确性。结论:在这个队列中,16%的双侧后环损伤从最初的骨盆CT被错误地分类为单侧。单侧完全性后环损伤应引起对侧隐匿性损伤的怀疑,如果临床需要,可能需要额外的x线或透视应力检查。
{"title":"Occult contralateral sacroiliac joint injuries missed on single-energy CT of operative pelvis fractures","authors":"Joseph T. Patterson ,&nbsp;Michael Allen ,&nbsp;Vivek Satish ,&nbsp;Andrew M. Duong ,&nbsp;Reza Firoozabadi ,&nbsp;Joshua L. Gary","doi":"10.1016/j.injury.2025.112952","DOIUrl":"10.1016/j.injury.2025.112952","url":null,"abstract":"<div><h3>Objective</h3><div>To determine the diagnostic performance of single-energy CT (SECT) scan for detecting contralateral posterior pelvic ring injuries in patients with an operative pelvis fracture.</div></div><div><h3>Methods</h3><div>Retrospective cohort study.</div></div><div><h3>Setting</h3><div>Level I Trauma Center</div></div><div><h3>Patient selection criteria</h3><div>Consecutive adults with operatively-treated pelvic ring injuries and preoperative and postoperative pelvis CT scans. Exclusion criteria were incomplete or unreadable imaging, pelvis CT obtained on a spine board or with a pelvic binder in place, prior pelvic instrumentation, or sacroiliac joint fusion.</div></div><div><h3>Outcome</h3><div><em>Measures and Comparisons</em>: An “occult” contralateral sacroiliac joint injury was defined as either (A) a positive change of ≥2.0 mm between preoperative and postoperative CT measurements at this level on the “uninjured” side or (B) an intraoperatively fluoroscopic finding of ≥2.0 mm of sacroiliac joint widening on either static or dynamic stress fluoroscopic imaging on the “uninjured” side not present on the initial, preoperative CT</div></div><div><h3>Results</h3><div>One hundred forty-six adults, 62 % male sex, with a mean age of 42.5 years were included. A unilateral posterior pelvic ring injury was identified on the initial pelvis CT in ninety patients. An occult contralateral sacroiliac joint injury was identified in 11 patients (12.2 %), 5 by intraoperative fluoroscopic examination, none during instrumentation, and 6 by postoperative pelvis CT. One U-type sacral fracture was identified on postoperative CT. The diagnostic performance of pelvis SECT in the initial trauma evaluation for correctly classifying bilateral pelvic ring injuries was 84 % sensitivity with a 16 % false negative rate, 100 % specificity, 88 % negative predictive value, and 92 % accuracy.</div></div><div><h3>Conclusions</h3><div>In this cohort, 16 % of bilateral posterior ring injuries were incorrectly classified as unilateral from the initial pelvis CT. A complete unilateral posterior ring injury should raise suspicion for an occult contralateral injury and may warrant additional radiographic or fluoroscopic stress examination if clinically appropriate.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 2","pages":"Article 112952"},"PeriodicalIF":2.0,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145829295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of the number of single door segments in the posterior cervical canal on the traction of the cervical 5 nerve root 颈后管单门节段数目对颈5神经根牵引的影响
IF 2 3区 医学 Q3 CRITICAL CARE MEDICINE Pub Date : 2025-12-10 DOI: 10.1016/j.injury.2025.112955
Mingjie Bai , Peng Yang

Background

The posterior cervical canal plays a critical role in the protection and function of the cervical nerve roots, particularly the C5 nerve root. Variations in its anatomical structure, notably the number of single-door segments, may impact the traction forces experienced by the C5 nerve root during surgical interventions or pathological conditions. This study aims to quantify how the number of single-door segments affects traction forces on the C5 nerve root.

Methods

A biomechanical model was developed to simulate traction forces on the C5 nerve root based on varying anatomical configurations of the posterior cervical canal. MRI scans from 60 patients were analyzed, and traction forces were calculated for different segmental configurations, specifically focusing on the number of single-door segments.

Results

The study revealed a statistically significant correlation between the number of single-door segments and the traction force on the C5 nerve root. As the number of segments increased from one to three, traction forces increased by 25%, with the mean force rising from 12.5 N to 17.2 N (p < 0.05). Furthermore, the force increased by an additional 6% when the number of segments reached four, reaching a maximum traction force of 18.3 N. These findings suggest that anatomical variations in the posterior cervical canal influence the magnitude of traction forces and could potentially alter surgical outcomes, especially in nerve root preservation during decompression procedures.

Conclusion

This study underscores the significant role of single-door segments in the posterior cervical canal in modulating traction forces on the C5 nerve root. These biomechanical insights offer valuable information for preoperative planning, particularly in surgeries involving cervical spine decompression. Understanding these dynamics could enhance the preservation of nerve root integrity and improve patient outcomes in cervical spine surgeries.
颈后管对颈神经根,特别是C5神经根的保护和功能起着至关重要的作用。其解剖结构的变化,特别是单门节段的数量,可能会影响C5神经根在手术干预或病理情况下所经历的牵引力。本研究旨在量化单门节段的数量如何影响C5神经根的牵引力。方法建立生物力学模型,模拟不同颈后管解剖形态对C5神经根的牵引力。分析了60例患者的MRI扫描结果,并计算了不同节段配置的牵引力,特别关注单门节段的数量。结果单门节段数与C5神经根牵引力有统计学意义。当节段数从1节增加到3节时,牵引力增加25%,平均牵引力从12.5 N增加到17.2 N (p < 0.05)。此外,当节段数达到4节时,牵引力增加了6%,达到18.3 n的最大牵引力。这些研究结果表明,颈后管的解剖变化会影响牵引力的大小,并可能改变手术结果,特别是在减压过程中保留神经根。结论颈椎后管单门节段对C5神经根牵引力的调节具有重要作用。这些生物力学见解为术前规划提供了有价值的信息,特别是在涉及颈椎减压的手术中。了解这些动态可以增强神经根完整性的保存,并改善颈椎手术患者的预后。
{"title":"The effect of the number of single door segments in the posterior cervical canal on the traction of the cervical 5 nerve root","authors":"Mingjie Bai ,&nbsp;Peng Yang","doi":"10.1016/j.injury.2025.112955","DOIUrl":"10.1016/j.injury.2025.112955","url":null,"abstract":"<div><h3>Background</h3><div>The posterior cervical canal plays a critical role in the protection and function of the cervical nerve roots, particularly the C5 nerve root. Variations in its anatomical structure, notably the number of single-door segments, may impact the traction forces experienced by the C5 nerve root during surgical interventions or pathological conditions. This study aims to quantify how the number of single-door segments affects traction forces on the C5 nerve root.</div></div><div><h3>Methods</h3><div>A biomechanical model was developed to simulate traction forces on the C5 nerve root based on varying anatomical configurations of the posterior cervical canal. MRI scans from 60 patients were analyzed, and traction forces were calculated for different segmental configurations, specifically focusing on the number of single-door segments.</div></div><div><h3>Results</h3><div>The study revealed a statistically significant correlation between the number of single-door segments and the traction force on the C5 nerve root. As the number of segments increased from one to three, traction forces increased by 25%, with the mean force rising from 12.5 N to 17.2 N (p &lt; 0.05). Furthermore, the force increased by an additional 6% when the number of segments reached four, reaching a maximum traction force of 18.3 N. These findings suggest that anatomical variations in the posterior cervical canal influence the magnitude of traction forces and could potentially alter surgical outcomes, especially in nerve root preservation during decompression procedures.</div></div><div><h3>Conclusion</h3><div>This study underscores the significant role of single-door segments in the posterior cervical canal in modulating traction forces on the C5 nerve root. These biomechanical insights offer valuable information for preoperative planning, particularly in surgeries involving cervical spine decompression. Understanding these dynamics could enhance the preservation of nerve root integrity and improve patient outcomes in cervical spine surgeries.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 2","pages":"Article 112955"},"PeriodicalIF":2.0,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145976449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrasonographic bridging callus as an early predictor of tibial fracture healing 超声桥接骨痂作为胫骨骨折愈合的早期预测指标。
IF 2 3区 医学 Q3 CRITICAL CARE MEDICINE Pub Date : 2025-12-10 DOI: 10.1016/j.injury.2025.112936
Guilherme Pelosini Gaiarsa, Paulo Roberto dos Reis, Olavo Pires de Camargo, Kodi Edson Kojima, Jorge Dos Santos Silva

Purpose

This study assessed whether ultrasonographic (U/S) detection of bridging callus can serve as an early sign of tibial fracture healing. By comparing U/S with serial radiographs, the goal was to identify the best predictors of fracture union. Previous studies indicate that early radiographic bridging callus may signal eventual healing, and U/S could detect this sooner than X-rays. Thus, U/S may provide earlier predictions of bone union or impaired healing.

Methods

A prospective evaluation was conducted on a consecutive cohort of patients with tibial fractures managed by intramedullary nailing. Patients were followed until complete bone healing or determination of nonunion at twelve months. Demographic and clinical data were collected contemporaneously. Radiographic and ultrasound images were obtained monthly and independently assessed by two experienced orthopaedic surgeons.

Results

Of the 42 initially enrolled patients 6 were lost to follow-up, resulting in the 36 included in the final cohort. There were 29 males and 7 females, aged between 22 and 64 years (mean, 39; median, 36.5). Fourteen fractures were open, with 20 classified as AO/OTA A, seven B, and nine C patterns. Of the 36 patients who completed the study, 31 healed uneventfully, while 5 did not achieve healing. An ultrasonographic bridging callus was observed between the first and third month following surgery. A "V"-shaped ultrasound corkscrew sign appeared in areas where no callus developed, and may serve as a prognostic factor for eventual nonunion. Bridging callus detected by ultrasound during the initial three months was identified as a positive prognostic indicator of bone healing.

Conclusion

Ultrasonography is rarely used to assess fracture healing, but it may help predict outcomes. Portable point-of-care ultrasound (POCUS) can reduce radiation in follow-ups. Detecting bridging callus on ultrasound within three months reliably indicates bone healing, often appearing a month before seen on X-ray and suggesting eventual union.
目的:本研究评估超声(U/S)检测桥接骨痂是否可以作为胫骨骨折愈合的早期征象。通过U/S与系列x线片的比较,目的是确定骨折愈合的最佳预测指标。先前的研究表明,早期的x线摄影桥接性骨痂可能是最终愈合的信号,而U/S可以比x射线更快地检测到这一点。因此,U/S可以提供骨愈合或愈合受损的早期预测。方法:对一组采用髓内钉治疗胫骨骨折的患者进行前瞻性评估。随访患者至12个月骨完全愈合或确定骨不连。同时收集人口统计学和临床数据。由两位经验丰富的骨科医生每月获得x线和超声图像并独立评估。结果:在最初纳入的42名患者中,有6名患者未能随访,最终纳入36名患者。男性29例,女性7例,年龄22 ~ 64岁,平均39岁,中位数36.5岁。14例骨折开放,20例为AO/OTA A型,7例为B型,9例为C型。在完成研究的36名患者中,31名患者痊愈,而5名患者没有痊愈。术后第1个月至第3个月超声检查发现骨痂桥。超声锥状征象出现在未形成骨痂的部位,可作为最终骨不连的预后因素。在最初的三个月内通过超声检测桥接骨痂被确定为骨愈合的积极预后指标。结论:超声检查很少用于评估骨折愈合,但可以帮助预测预后。便携式即时超声(POCUS)可以减少随访中的辐射。在三个月内用超声波检测到桥接性骨痂,可以可靠地表明骨愈合,通常在x光检查前一个月出现,表明最终愈合。
{"title":"Ultrasonographic bridging callus as an early predictor of tibial fracture healing","authors":"Guilherme Pelosini Gaiarsa,&nbsp;Paulo Roberto dos Reis,&nbsp;Olavo Pires de Camargo,&nbsp;Kodi Edson Kojima,&nbsp;Jorge Dos Santos Silva","doi":"10.1016/j.injury.2025.112936","DOIUrl":"10.1016/j.injury.2025.112936","url":null,"abstract":"<div><h3>Purpose</h3><div>This study assessed whether ultrasonographic (U/S) detection of bridging callus can serve as an early sign of tibial fracture healing. By comparing U/S with serial radiographs, the goal was to identify the best predictors of fracture union. Previous studies indicate that early radiographic bridging callus may signal eventual healing, and U/S could detect this sooner than X-rays. Thus, U/S may provide earlier predictions of bone union or impaired healing.</div></div><div><h3>Methods</h3><div>A prospective evaluation was conducted on a consecutive cohort of patients with tibial fractures managed by intramedullary nailing. Patients were followed until complete bone healing or determination of nonunion at twelve months. Demographic and clinical data were collected contemporaneously. Radiographic and ultrasound images were obtained monthly and independently assessed by two experienced orthopaedic surgeons.</div></div><div><h3>Results</h3><div>Of the 42 initially enrolled patients 6 were lost to follow-up, resulting in the 36 included in the final cohort. There were 29 males and 7 females, aged between 22 and 64 years (mean, 39; median, 36.5). Fourteen fractures were open, with 20 classified as AO/OTA A, seven B, and nine C patterns. Of the 36 patients who completed the study, 31 healed uneventfully, while 5 did not achieve healing. An ultrasonographic bridging callus was observed between the first and third month following surgery. A \"V\"-shaped ultrasound corkscrew sign appeared in areas where no callus developed, and may serve as a prognostic factor for eventual nonunion. Bridging callus detected by ultrasound during the initial three months was identified as a positive prognostic indicator of bone healing.</div></div><div><h3>Conclusion</h3><div>Ultrasonography is rarely used to assess fracture healing, but it may help predict outcomes. Portable point-of-care ultrasound (POCUS) can reduce radiation in follow-ups. Detecting bridging callus on ultrasound within three months reliably indicates bone healing, often appearing a month before seen on X-ray and suggesting eventual union.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 2","pages":"Article 112936"},"PeriodicalIF":2.0,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145822424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accuracy of portable intraoperative CT with 3D computer navigation versus freehand fluoroscopy-assisted pedicle screw placement in thoracolumbar spine surgery 便携式术中CT三维计算机导航与徒手透视辅助下胸腰椎椎弓根螺钉置入的准确性比较。
IF 2 3区 医学 Q3 CRITICAL CARE MEDICINE Pub Date : 2025-12-09 DOI: 10.1016/j.injury.2025.112953
Hou-Tsung Chen , Yow-Ling Shiue , Cheng-Tang Pan , Re-Wen Wu
Accurate placement of pedicle screws is crucial for avoiding complications such as nerve damage or vascular injury. Screws are typically placed freehand using fluoroscopy-guidance. Recently, portable CT combined with 3D navigation (3D-N-iCT) has been developed to guide the placement of pedicle screws. This study compares the accuracy of pedicle screw placement using 3D-N-iCT versus the conventional freehand fluoroscopy guidance for thoracolumbar surgery. The records of patients who underwent thoracolumbar spine surgery with pedicle screw placement from November 2017 to December 2022 at Kaohsiung Chang Gung Memorial Hospital were retrospectively reviewed. Patients were divided into those in which 3D-N-iCT was used and those in whom screws were placed with freehand fluoroscopy guidance (FH-F). Outcomes compared between the 2 groups included screw placement accuracy assessed using the Gertzbein classification, and post-operative complications. A total of 244 patients were included in the study, with 182 in the 3D-N-iCT group and 62 in the FH-F group. The accuracy of screw placement was significantly higher in the 3D-N-iCT group, with 98 % of screws classified as Grade 0 (indicating perfectly positioned) compared to 93 % in the FH-F group (p = 0.010). The placement time was similar between groups (36.0 vs. 33.0 min, p = 0.120). The 3D-N-iCT group had a significantly lower rate of post-operative neurological defects (0 % vs. 5 %, p = 0.016) and complications (0.5 % vs. 8 %, p = 0.004). In conclusions, the use of 3D-N-iCT is associated with greater accuracy in pedicle screw placement during thoracolumbar spine surgeries compared to the freehand technique, without prolonging placement time.
椎弓根螺钉的准确放置对于避免神经损伤或血管损伤等并发症至关重要。螺钉通常在透视引导下徒手放置。最近,便携式CT结合3D导航(3D- n - ict)已被开发用于指导椎弓根螺钉的放置。本研究比较了在胸腰椎手术中使用3D-N-iCT与传统的徒手透视引导椎弓根螺钉置入的准确性。回顾性分析2017年11月至2022年12月在高雄长庚纪念医院行胸腰椎手术置椎弓根螺钉患者的记录。患者分为使用3D-N-iCT组和徒手透视引导(FH-F)放置螺钉组。两组间比较的结果包括使用Gertzbein分类评估螺钉放置准确性和术后并发症。研究共纳入244例患者,其中3D-N-iCT组182例,FH-F组62例。3D-N-iCT组螺钉放置的准确性明显更高,98%的螺钉被分类为0级(表示完全定位),而FH-F组为93% (p = 0.010)。两组置入时间相似(36.0 min vs. 33.0 min, p = 0.120)。3D-N-iCT组术后神经缺损发生率(0 %比5 %,p = 0.016)和并发症发生率(0.5 %比8 %,p = 0.004)显著低于3D-N-iCT组。总之,与徒手技术相比,在胸腰椎手术中使用3D-N-iCT可以更准确地放置椎弓根螺钉,而不会延长放置时间。
{"title":"Accuracy of portable intraoperative CT with 3D computer navigation versus freehand fluoroscopy-assisted pedicle screw placement in thoracolumbar spine surgery","authors":"Hou-Tsung Chen ,&nbsp;Yow-Ling Shiue ,&nbsp;Cheng-Tang Pan ,&nbsp;Re-Wen Wu","doi":"10.1016/j.injury.2025.112953","DOIUrl":"10.1016/j.injury.2025.112953","url":null,"abstract":"<div><div>Accurate placement of pedicle screws is crucial for avoiding complications such as nerve damage or vascular injury. Screws are typically placed freehand using fluoroscopy-guidance. Recently, portable CT combined with 3D navigation (3D-N-iCT) has been developed to guide the placement of pedicle screws. This study compares the accuracy of pedicle screw placement using 3D-N-iCT versus the conventional freehand fluoroscopy guidance for thoracolumbar surgery. The records of patients who underwent thoracolumbar spine surgery with pedicle screw placement from November 2017 to December 2022 at Kaohsiung Chang Gung Memorial Hospital were retrospectively reviewed. Patients were divided into those in which 3D-N-iCT was used and those in whom screws were placed with freehand fluoroscopy guidance (FH-F). Outcomes compared between the 2 groups included screw placement accuracy assessed using the Gertzbein classification, and post-operative complications. A total of 244 patients were included in the study, with 182 in the 3D-N-iCT group and 62 in the FH-F group. The accuracy of screw placement was significantly higher in the 3D-N-iCT group, with 98 % of screws classified as Grade 0 (indicating perfectly positioned) compared to 93 % in the FH-F group (<em>p</em> = 0.010). The placement time was similar between groups (36.0 vs. 33.0 min, <em>p</em> = 0.120). The 3D-N-iCT group had a significantly lower rate of post-operative neurological defects (0 % vs. 5 %, <em>p</em> = 0.016) and complications (0.5 % vs. 8 %, <em>p</em> = 0.004). In conclusions, the use of 3D-N-iCT is associated with greater accuracy in pedicle screw placement during thoracolumbar spine surgeries compared to the freehand technique, without prolonging placement time.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 2","pages":"Article 112953"},"PeriodicalIF":2.0,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and multicenter validation of a machine learning model for postoperative sepsis risk in critically Ill traumatic spinal injury patients 危重创伤性脊柱损伤患者术后脓毒症风险机器学习模型的开发和多中心验证
IF 2 3区 医学 Q3 CRITICAL CARE MEDICINE Pub Date : 2025-12-09 DOI: 10.1016/j.injury.2025.112949
Yixi Wang , Wenzhe Li , Jian Cui , Zexi Wang , Yuqian Li

Objective

To develop and validate a machine learning model for postoperative sepsis in critically ill traumatic spinal injury (TSI) patients, a frequent and severe complication without dedicated predictive tools.

Methods

Model development used the MIMIC-IV 3.1 database, with external validation in the eICU-CRD 2.0 database and a Chinese TSI cohort. Variables documented within 24 h of postoperative ICU admission were screened using univariable testing and refined through Boruta and Group-Lasso regression to identify the final predictors. Thirteen base learners were trained and combined in a stacking ensemble optimized by fivefold cross-validation and hyperparameter tuning. Performance was assessed using receiver operating characteristic (ROC-AUC), average precision from precision–recall (PR-AP), calibration, decision, and lift curves, along with accuracy, sensitivity, specificity, precision, and F1 scores. Interpretability was evaluated through SHAP analysis.

Results

The development cohort comprised 808 patients, with 461 (57.1 %) sepsis cases, and the external validation cohort consisted of 358 patients, with 86 (24.0 %) events. Twelve predictors entered modeling, with the stacking model achieving an ROC-AUC of 0.918 and PR-AP of 0.938 in training and 0.889 and 0.936 in validation, maintaining close calibration, superior clinical utility confirmed by decision and lift curves, and balanced classification metrics, while most first-level models deteriorated markedly. External validation confirmed consistent performance and effective high-risk stratification. SHAP analysis underscored surgical burden, severity, hemodynamic, renal, and coagulation domains as key contributors, ensuring interpretability at cohort and individual levels.

Conclusion

This first validated model for postoperative sepsis in critically ill TSI patients shows relatively robust performance and interpretability, enabling early risk stratification and supporting clinical decision-making.
目的开发并验证危重性创伤性脊髓损伤(TSI)患者术后脓毒症的机器学习模型,TSI是一种常见且严重的并发症,没有专门的预测工具。方法模型开发使用MIMIC-IV 3.1数据库,并在eICU-CRD 2.0数据库和中国TSI队列中进行外部验证。采用单变量检验筛选ICU术后入院24小时内记录的变量,并通过Boruta和Group-Lasso回归进行细化,以确定最终预测因子。13个基础学习器被训练并组合成一个通过五倍交叉验证和超参数调谐优化的堆叠集成。使用接收器工作特性(ROC-AUC)、精密度-召回率(PR-AP)的平均精密度、校准、决策和升程曲线,以及准确度、灵敏度、特异性、精密度和F1分数来评估性能。通过SHAP分析评估可解释性。结果发展队列包括808例患者,461例(57.1%)脓毒症病例,外部验证队列包括358例患者,86例(24.0%)脓毒症事件。12个预测因子进入建模,其中叠加模型训练时的ROC-AUC为0.918,PR-AP为0.938,验证时的PR-AP为0.889和0.936,保持了密切的校准,决策曲线和提升曲线证实了较好的临床效用,分类指标平衡,而大多数一级模型明显恶化。外部验证证实了一致的性能和有效的高风险分层。SHAP分析强调手术负担、严重程度、血流动力学、肾脏和凝血域是关键因素,确保了队列和个体水平的可解释性。结论:该模型首次验证了危重TSI患者术后脓毒症的性能和可解释性,可实现早期风险分层并支持临床决策。
{"title":"Development and multicenter validation of a machine learning model for postoperative sepsis risk in critically Ill traumatic spinal injury patients","authors":"Yixi Wang ,&nbsp;Wenzhe Li ,&nbsp;Jian Cui ,&nbsp;Zexi Wang ,&nbsp;Yuqian Li","doi":"10.1016/j.injury.2025.112949","DOIUrl":"10.1016/j.injury.2025.112949","url":null,"abstract":"<div><h3>Objective</h3><div>To develop and validate a machine learning model for postoperative sepsis in critically ill traumatic spinal injury (TSI) patients, a frequent and severe complication without dedicated predictive tools.</div></div><div><h3>Methods</h3><div>Model development used the MIMIC-IV 3.1 database, with external validation in the eICU-CRD 2.0 database and a Chinese TSI cohort. Variables documented within 24 h of postoperative ICU admission were screened using univariable testing and refined through Boruta and Group-Lasso regression to identify the final predictors. Thirteen base learners were trained and combined in a stacking ensemble optimized by fivefold cross-validation and hyperparameter tuning. Performance was assessed using receiver operating characteristic (ROC-AUC), average precision from precision–recall (PR-AP), calibration, decision, and lift curves, along with accuracy, sensitivity, specificity, precision, and F1 scores. Interpretability was evaluated through SHAP analysis.</div></div><div><h3>Results</h3><div>The development cohort comprised 808 patients, with 461 (57.1 %) sepsis cases, and the external validation cohort consisted of 358 patients, with 86 (24.0 %) events. Twelve predictors entered modeling, with the stacking model achieving an ROC-AUC of 0.918 and PR-AP of 0.938 in training and 0.889 and 0.936 in validation, maintaining close calibration, superior clinical utility confirmed by decision and lift curves, and balanced classification metrics, while most first-level models deteriorated markedly. External validation confirmed consistent performance and effective high-risk stratification. SHAP analysis underscored surgical burden, severity, hemodynamic, renal, and coagulation domains as key contributors, ensuring interpretability at cohort and individual levels.</div></div><div><h3>Conclusion</h3><div>This first validated model for postoperative sepsis in critically ill TSI patients shows relatively robust performance and interpretability, enabling early risk stratification and supporting clinical decision-making.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 2","pages":"Article 112949"},"PeriodicalIF":2.0,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145747730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Injury-International Journal of the Care of the Injured
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