Pub Date : 2026-03-01Epub Date: 2026-01-09DOI: 10.1016/j.injury.2026.113028
Ali Edalat Irani , Mohammad Reza Farahpour , Mohammad Reza Valilou , Zohreh Ghazi Tabatabaei
Hydrogels have emerged as effective tools in medication delivery and tissue engineering due to their adjustable characteristics and water retention capabilities. The purpose of this work was to investigate the potential of a novel thermosensitive hydrogel composed of Pluronic F127 and polyglutamic acid (PGA) to enhance the treatment of MRSA-infected full-thickness excision wounds. The viscosity and gelation temperature of the hydrogels were evaluated using viscometry and rheometry, while their injectability was assessed with a texture analyzer. Swelling and biodegradation were measured in PBS at 37 °C, and antibacterial and antioxidant activity was determined using MIC/MBC tests and DPPH radical scavenging. In mouse infected wound healing investigations, hydrogels were applied to wounds, and tissue examination was done with Masson's Trichrome staining and biochemical assays for TAC and MDA. The F127/PGA hydrogel converted from a liquid to a gel at body temperature more efficiently than F127 alone, with lower gelation temperatures and improved mechanical characteristics. F127/PGA had higher swelling capacity and a slower degradation rate than F127. In antibacterial assays, the F127/PGA hydrogel showed stronger inhibitory and bactericidal activity against MRSA, as reflected by its lower MIC and higher MBC values. In addition, the hydrogel showed increased antioxidant activity and lower oxidative stress during wound healing, resulting in much better wound contraction and tissue regeneration than F127 and control treatments. These characteristics make F127/PGA an attractive choice for improved drug delivery systems and wound healing applications.
{"title":"Accelerating the healing of infected full thickness excision wounds through the topical use of Pluronic F127 copolymer and Polyglutamic acid","authors":"Ali Edalat Irani , Mohammad Reza Farahpour , Mohammad Reza Valilou , Zohreh Ghazi Tabatabaei","doi":"10.1016/j.injury.2026.113028","DOIUrl":"10.1016/j.injury.2026.113028","url":null,"abstract":"<div><div>Hydrogels have emerged as effective tools in medication delivery and tissue engineering due to their adjustable characteristics and water retention capabilities. The purpose of this work was to investigate the potential of a novel thermosensitive hydrogel composed of Pluronic F127 and polyglutamic acid (PGA) to enhance the treatment of MRSA-infected full-thickness excision wounds. The viscosity and gelation temperature of the hydrogels were evaluated using viscometry and rheometry, while their injectability was assessed with a texture analyzer. Swelling and biodegradation were measured in PBS at 37 °C, and antibacterial and antioxidant activity was determined using MIC/MBC tests and DPPH radical scavenging. In mouse infected wound healing investigations, hydrogels were applied to wounds, and tissue examination was done with Masson's Trichrome staining and biochemical assays for TAC and MDA. The F127/PGA hydrogel converted from a liquid to a gel at body temperature more efficiently than F127 alone, with lower gelation temperatures and improved mechanical characteristics. F127/PGA had higher swelling capacity and a slower degradation rate than F127. In antibacterial assays, the F127/PGA hydrogel showed stronger inhibitory and bactericidal activity against MRSA, as reflected by its lower MIC and higher MBC values. In addition, the hydrogel showed increased antioxidant activity and lower oxidative stress during wound healing, resulting in much better wound contraction and tissue regeneration than F127 and control treatments. These characteristics make F127/PGA an attractive choice for improved drug delivery systems and wound healing applications.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 3","pages":"Article 113028"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146121349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-11DOI: 10.1016/j.injury.2026.113051
Sebastian Skovdal Winther , Upender Martin Singh , Allan Evald Nielsen , Michael Mørk Petersen , Arvind von Keudell
Background and purpose
Unstable pelvic ring fractures are severe injuries with substantial mortality and a high burden of associated injuries. Advances in trauma care have improved outcomes. However, recent data from high-volume centers remain scarce. We aimed to evaluate mortality, associated injuries, and predictors of mortality in surgically treated unstable pelvic ring fractures.
Methods
We retrospectively analyzed 451 consecutive patients with surgically treated Tile B or C pelvic ring fractures admitted to a Level 1 trauma center between 2008 and 2021. Patient demographics, injury characteristics, and associated injuries were recorded. Kaplan–Meier methods were used to estimate survival, and Cox regression for identifying independent predictors of mortality.
Results
Overall mortality at 3-month was 4.2% (95% CI 2.3–6.0) and at 1-year at 6.0% (95% CI 3.8–8.2). Tile C fractures had a higher early mortality than Tile B (3-month: 6.5% vs. 2.1%; 1-year: 7.4% vs. 4.7%). Associated injuries were common: 78% of patients had at least one and 66% had two or more injured regions. Patients with injuries in ≥2 regions had markedly higher intensive care unit (ICU) admission, transfusion requirements, and early mortality. In multivariable Cox regression, age (HR 1.06 per year), Glascow Coma Scale (GCS) ≤8 (HR 4.9), and Tile C (HR 3.6) were independently associated with 90-day mortality.
Conclusion
Mortality after surgically treated unstable pelvic ring fractures at 3- month and 1 year was 4.2% and 6.0%, respectively. Age, low GCS, and Tile C fracture pattern were independent predictors of early death. Associated injuries and overall trauma burden were strongly associated with ICU admission, transfusion, and early mortality.
背景和目的：不稳定骨盆环骨折是一种严重的损伤，死亡率高，相关损伤负担高。创伤护理的进步改善了治疗效果。然而，最近来自高容量中心的数据仍然很少。我们的目的是评估手术治疗不稳定骨盆环骨折的死亡率、相关损伤和死亡率预测因素。方法：我们回顾性分析了2008年至2021年间在一级创伤中心连续收治的451例手术治疗的B或C级骨盆环骨折患者。记录患者人口统计、损伤特征和相关损伤。Kaplan-Meier法用于估计生存率，Cox回归用于确定死亡率的独立预测因子。结果：3个月的总死亡率为4.2% (95% CI 2.3-6.0)， 1年的总死亡率为6.0% （95% CI 3.8-8.2）。C片骨折的早期死亡率高于B片（3个月：6.5% vs. 2.1%； 1年：7.4% vs. 4.7%）。相关损伤很常见：78%的患者至少有一个区域受伤，66%的患者有两个或更多区域受伤。损伤≥2个区域的患者重症监护病房（ICU）入院率、输血需求和早期死亡率明显较高。在多变量Cox回归中，年龄（HR 1.06 /年）、Glascow昏迷量表(GCS)≤8 （HR 4.9）和Tile C （HR 3.6）与90天死亡率独立相关。结论：不稳定骨盆环骨折术后3个月和1年的死亡率分别为4.2%和6.0%。年龄、低GCS和Tile C骨折类型是早期死亡的独立预测因素。相关损伤和总体创伤负担与ICU入院、输血和早期死亡率密切相关。
{"title":"Unstable Pelvic ring fractures managed surgically: A 13-year cohort study of patient characteristics, associated injuries, and predictors of early mortality","authors":"Sebastian Skovdal Winther , Upender Martin Singh , Allan Evald Nielsen , Michael Mørk Petersen , Arvind von Keudell","doi":"10.1016/j.injury.2026.113051","DOIUrl":"10.1016/j.injury.2026.113051","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Unstable pelvic ring fractures are severe injuries with substantial mortality and a high burden of associated injuries. Advances in trauma care have improved outcomes. However, recent data from high-volume centers remain scarce. We aimed to evaluate mortality, associated injuries, and predictors of mortality in surgically treated unstable pelvic ring fractures.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 451 consecutive patients with surgically treated Tile B or C pelvic ring fractures admitted to a Level 1 trauma center between 2008 and 2021. Patient demographics, injury characteristics, and associated injuries were recorded. Kaplan–Meier methods were used to estimate survival, and Cox regression for identifying independent predictors of mortality.</div></div><div><h3>Results</h3><div>Overall mortality at 3-month was 4.2% (95% CI 2.3–6.0) and at 1-year at 6.0% (95% CI 3.8–8.2). Tile C fractures had a higher early mortality than Tile B (3-month: 6.5% vs. 2.1%; 1-year: 7.4% vs. 4.7%). Associated injuries were common: 78% of patients had at least one and 66% had two or more injured regions. Patients with injuries in ≥2 regions had markedly higher intensive care unit (ICU) admission, transfusion requirements, and early mortality. In multivariable Cox regression, age (HR 1.06 per year), Glascow Coma Scale (GCS) ≤8 (HR 4.9), and Tile C (HR 3.6) were independently associated with 90-day mortality.</div></div><div><h3>Conclusion</h3><div>Mortality after surgically treated unstable pelvic ring fractures at 3- month and 1 year was 4.2% and 6.0%, respectively. Age, low GCS, and Tile C fracture pattern were independent predictors of early death. Associated injuries and overall trauma burden were strongly associated with ICU admission, transfusion, and early mortality.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 3","pages":"Article 113051"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-10DOI: 10.1016/j.injury.2026.113035
Ahmed Farid Mekky, Mohammed Sadakah, Hosam Mohamed Ghaly, Mohamed Rohayem, Mohammed Roshdy El-Tabbakh
Background:
Chronic acromio-clavicular dislocation is a challenging injury to treat. Many surgical procedures are available for its management which may be anatomical or non-anatomical. The aim of this study was to assess the clinical and radiological outcome in the patients with chronic acromio-clavicular dislocation treated by hybrid biological semitendinosus autograft and synthetic non-absorbable sutures.
Methods:
From July 2021 to January 2025, 21 patients with chronic acromio-clavicular dislocation were treated by hybrid biological semitendinosus autograft and synthetic non-absorbable sutures. Grade III to VI chronic acromio-clavicular injuries were included. Post-operatively, the patients were clinically assessed using Constant shoulder and Acromio-clavicular joint instability scores. Acromio-clavicular arthritis, coraco-clavicular ossification, distal clavicle osteolysis, coraco-clavicular and acromio-clavicular distances were radiologically evaluated.
Results:
The mean age at time of surgery was 28.52 ± 8.0 (range: 19-45) years. The acromio-clavicular dislocation was type III in 7 patients (33.4 %), type IV in 12 patients ( %57.1) and type V in 2 patients (9.5 %). The mean follow-up period was 24.29 ± 3.51 (range: 18-30) months. The mean post-operative Acromio-clavicular joint instability and Constant shoulder scores were 93.14 ± 8.16 (range: 78-100) and 90.14 ± 8.16 (range: 80-100) points respectively. None of the patients showed recurrent dislocation, arthritis and distal clavicle osteolysis.
Conclusion:
Bi-modal stabilization using hybrid biological semitendinosus autograft and synthetic non-absorbable sutures is an effective and reliable surgical option to treat chronic acromio-clavicular dislocation. Most of the reported complications associated with this procedure didn’t affect the functional outcome.
{"title":"Chronic acromio-clavicular dislocation: Bi-modal stabilization","authors":"Ahmed Farid Mekky, Mohammed Sadakah, Hosam Mohamed Ghaly, Mohamed Rohayem, Mohammed Roshdy El-Tabbakh","doi":"10.1016/j.injury.2026.113035","DOIUrl":"10.1016/j.injury.2026.113035","url":null,"abstract":"<div><h3>Background:</h3><div>Chronic acromio-clavicular dislocation is a challenging injury to treat. Many surgical procedures are available for its management which may be anatomical or non-anatomical. The aim of this study was to assess the clinical and radiological outcome in the patients with chronic acromio-clavicular dislocation treated by hybrid biological semitendinosus autograft and synthetic non-absorbable sutures.</div></div><div><h3>Methods:</h3><div>From July 2021 to January 2025, 21 patients with chronic acromio-clavicular dislocation were treated by hybrid biological semitendinosus autograft and synthetic non-absorbable sutures. Grade III to VI chronic acromio-clavicular injuries were included. Post-operatively, the patients were clinically assessed using Constant shoulder and Acromio-clavicular joint instability scores. Acromio-clavicular arthritis, coraco-clavicular ossification, distal clavicle osteolysis, coraco-clavicular and acromio-clavicular distances were radiologically evaluated.</div></div><div><h3>Results:</h3><div>The mean age at time of surgery was 28.52 ± 8.0 (range: 19-45) years. The acromio-clavicular dislocation was type III in 7 patients (33.4 %), type IV in 12 patients ( %57.1) and type V in 2 patients (9.5 %). The mean follow-up period was 24.29 ± 3.51 (range: 18-30) months. The mean post-operative Acromio-clavicular joint instability and Constant shoulder scores were 93.14 ± 8.16 (range: 78-100) and 90.14 ± 8.16 (range: 80-100) points respectively. None of the patients showed recurrent dislocation, arthritis and distal clavicle osteolysis.</div></div><div><h3>Conclusion:</h3><div>Bi-modal stabilization using hybrid biological semitendinosus autograft and synthetic non-absorbable sutures is an effective and reliable surgical option to treat chronic acromio-clavicular dislocation. Most of the reported complications associated with this procedure didn’t affect the functional outcome.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 3","pages":"Article 113035"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146014128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-10DOI: 10.1016/j.injury.2026.113043
Bianca Rocha da Silva Barreto , Eduardo Carvalho Lira , Severino Alves Júnior , Luzia Abilio da Silva , Yuri José de Albuquerque Silva , Widarlane Ângela da Silva Alves , Madson Manoel Nunes da Silva , Rosallyne Hosana Vanderlei das Chagas , Larissa Cardeal da Rocha Carvalho , Jasmine Martins Vieira Cunha , Jamily Isabel Viana de Lima , Ester Francisca Gomes de Lima , Ícaro Mota Oliveira , Jeymesson Raphael Cardoso Vieira
Skin flaps are widely used in plastic and reconstructive surgery. However, inadequate blood perfusion during flap mobilization can trigger an ischemic process that may lead to tissue necrosis in the absence of effective management of the inflammatory process. In this context, the search for new biocompatible strategies to ensure the viability of ischemic skin flaps (ISFs) remains necessary. Therefore, this study evaluated novel alginate-ZIF-8 (ALG-ZIF-8) hydrogel systems with Rhizophora mangle (R. mangle) extract and tannic acid (TA) to assess their potential in preventing necrosis in ISF. Twenty-two male Wistar rats underwent the surgical creation of ISF and were divided into four groups: 0.9% saline (negative control - NegC), placebo alginate hydrogel (pALGgel), ALG-ZIF-8 hydrogel system with 5% TA (ALGzTA), and finally, ALG-ZIF-8 hydrogel system with 5% R. mangle (ALGzRm). Flap outcomes were evaluated through macroscopic observation, followed by morphometric analysis of viable and necrotic areas, and histomorphometric analysis of fibroblasts, blood vessels, and leukocytes, using ImageJ and PrimeCam 5.1 software. Statistical analysis was performed using IBM SPSS software (version 27). The results suggest that the formulations produced divergent outcomes by differentially modulating inflammatory and angiogenic responses. The ALGzRm formulation tended to show a protective profile, associated with a significant reduction in leukocyte infiltration (p < 0.001), while the ALGzTA formulation was linked to a detrimental response, including exacerbated inflammation and a pathologically high blood vessel count (p = 0.015). In conclusion, findings suggest that the ALGzRm-gel has a potential for tissue repair, mediated by the modulation of inflammatory and angiogenic responses.
皮瓣广泛应用于整形和重建手术。然而，在皮瓣动员过程中，血液灌注不足会引发缺血过程，在炎症过程缺乏有效管理的情况下可能导致组织坏死。在这种情况下，寻找新的生物相容性策略来确保缺血皮瓣（isf）的生存能力仍然是必要的。因此，本研究评估了新型海藻酸盐- zif -8 （ALG-ZIF-8）水凝胶体系与根霉（R. mangle）提取物和单宁酸（TA），以评估其预防ISF坏死的潜力。22只雄性Wistar大鼠手术生成ISF，分为四组：0.9%生理盐水（阴性对照- NegC）、安慰剂海藻酸盐水凝胶（pALGgel）、5% TA的ALG-ZIF-8水凝胶体系（ALGzTA）和5% R. mangle的ALG-ZIF-8水凝胶体系（ALGzRm）。采用ImageJ和PrimeCam 5.1软件对皮瓣进行宏观观察、活区和坏死区形态学分析、成纤维细胞、血管和白细胞的组织形态学分析。采用IBM SPSS软件（27版）进行统计分析。结果表明，配方产生不同的结果，通过不同的调节炎症和血管生成反应。ALGzRm配方倾向于显示出保护作用，与白细胞浸润的显著减少有关（p < 0.001），而ALGzTA配方与有害反应有关，包括炎症加剧和病理性高血管计数（p = 0.015）。总之，研究结果表明，通过调节炎症和血管生成反应，algzrm -凝胶具有组织修复的潜力。
{"title":"Ischemic skin flap viability: in vivo study of alginate-ZIF-8 hydrogel systems with Rhizophora mangle and tannic acid","authors":"Bianca Rocha da Silva Barreto , Eduardo Carvalho Lira , Severino Alves Júnior , Luzia Abilio da Silva , Yuri José de Albuquerque Silva , Widarlane Ângela da Silva Alves , Madson Manoel Nunes da Silva , Rosallyne Hosana Vanderlei das Chagas , Larissa Cardeal da Rocha Carvalho , Jasmine Martins Vieira Cunha , Jamily Isabel Viana de Lima , Ester Francisca Gomes de Lima , Ícaro Mota Oliveira , Jeymesson Raphael Cardoso Vieira","doi":"10.1016/j.injury.2026.113043","DOIUrl":"10.1016/j.injury.2026.113043","url":null,"abstract":"<div><div>Skin flaps are widely used in plastic and reconstructive surgery. However, inadequate blood perfusion during flap mobilization can trigger an ischemic process that may lead to tissue necrosis in the absence of effective management of the inflammatory process. In this context, the search for new biocompatible strategies to ensure the viability of ischemic skin flaps (ISFs) remains necessary. Therefore, this study evaluated novel alginate-ZIF-8 (ALG-ZIF-8) hydrogel systems with <em>Rhizophora mangle</em> (<em>R. mangle</em>) extract and tannic acid (TA) to assess their potential in preventing necrosis in ISF. Twenty-two male Wistar rats underwent the surgical creation of ISF and were divided into four groups: 0.9% saline (negative control - NegC), placebo alginate hydrogel (pALGgel), ALG-ZIF-8 hydrogel system with 5% TA (ALGzTA), and finally, ALG-ZIF-8 hydrogel system with 5% <em>R. mangle</em> (ALGzRm). Flap outcomes were evaluated through macroscopic observation, followed by morphometric analysis of viable and necrotic areas, and histomorphometric analysis of fibroblasts, blood vessels, and leukocytes, using ImageJ and PrimeCam 5.1 software. Statistical analysis was performed using IBM SPSS software (version 27). The results suggest that the formulations produced divergent outcomes by differentially modulating inflammatory and angiogenic responses. The ALGzRm formulation tended to show a protective profile, associated with a significant reduction in leukocyte infiltration (<em>p</em> < 0.001), while the ALGzTA formulation was linked to a detrimental response, including exacerbated inflammation and a pathologically high blood vessel count (<em>p</em> = 0.015). In conclusion, findings suggest that the ALGzRm-gel has a potential for tissue repair, mediated by the modulation of inflammatory and angiogenic responses.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 3","pages":"Article 113043"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145981493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-10DOI: 10.1016/j.injury.2026.113041
Mahmoud Omar , Nailah Ghouse , Alexander Azar , Sarah Atta , Wassim Malak
Introduction
Open globe injury is a surgical emergency requiring prompt diagnosis to minimize morbidity. Orbital CT is frequently performed in trauma settings and is crucial for globe evaluation, particularly when bedside assessment is limited.
The primary objective was to evaluate the diagnostic accuracy of overall CT impression for detecting open globe injury. The secondary objective was to assess the diagnostic accuracy of CT imaging signs.
Methods
A systematic review protocol was prospectively registered (PROSPERO CRD42025638703). On January 16, 2025, Embase, Pubmed, Scopus, and Google Scholar were searched without date restrictions. Diagnostic accuracy meta-analyses were performed on overall CT impression and individual CT imaging signs for open globe injury. Risk of bias was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 tool.
Results
Eight studies met inclusion criteria representing 827 patients, 830 injured globes, and 339 confirmed open globe injury. The pooled sensitivity and specificity of overall CT impression was 75% (95% CI, 0.69–0.79) and 94% (95% CI, 0.91–0.96), respectively. Among individual signs, change in globe contour or scleral irregularity had the highest diagnostic odds ratio (109; 95% CI, 17–718) with sensitivity and specificity of 71% (95% CI, 0.61–0.79) and 98% (95% CI, 0.86–1.00), respectively. Change in anterior chamber depth, vitreous hemorrhage, lens abnormality, and intraocular air were insensitive but highly specific signs.
Conclusions
Overall CT impression and individual imaging signs demonstrate high specificity but limited sensitivity for open globe injury. Surgical exploration remains necessary when clinical suspicion persists despite inconclusive imaging.
{"title":"Diagnostic test accuracy of CT for open globe injury: A systematic review and meta-analysis of overall impression and individual imaging signs","authors":"Mahmoud Omar , Nailah Ghouse , Alexander Azar , Sarah Atta , Wassim Malak","doi":"10.1016/j.injury.2026.113041","DOIUrl":"10.1016/j.injury.2026.113041","url":null,"abstract":"<div><h3>Introduction</h3><div>Open globe injury is a surgical emergency requiring prompt diagnosis to minimize morbidity. Orbital CT is frequently performed in trauma settings and is crucial for globe evaluation, particularly when bedside assessment is limited.</div><div>The primary objective was to evaluate the diagnostic accuracy of overall CT impression for detecting open globe injury. The secondary objective was to assess the diagnostic accuracy of CT imaging signs.</div></div><div><h3>Methods</h3><div>A systematic review protocol was prospectively registered (PROSPERO CRD42025638703). On January 16, 2025, Embase, Pubmed, Scopus, and Google Scholar were searched without date restrictions. Diagnostic accuracy meta-analyses were performed on overall CT impression and individual CT imaging signs for open globe injury. Risk of bias was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 tool.</div></div><div><h3>Results</h3><div>Eight studies met inclusion criteria representing 827 patients, 830 injured globes, and 339 confirmed open globe injury. The pooled sensitivity and specificity of overall CT impression was 75% (95% CI, 0.69–0.79) and 94% (95% CI, 0.91–0.96), respectively. Among individual signs, change in globe contour or scleral irregularity had the highest diagnostic odds ratio (109; 95% CI, 17–718) with sensitivity and specificity of 71% (95% CI, 0.61–0.79) and 98% (95% CI, 0.86–1.00), respectively. Change in anterior chamber depth, vitreous hemorrhage, lens abnormality, and intraocular air were insensitive but highly specific signs.</div></div><div><h3>Conclusions</h3><div>Overall CT impression and individual imaging signs demonstrate high specificity but limited sensitivity for open globe injury. Surgical exploration remains necessary when clinical suspicion persists despite inconclusive imaging.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 3","pages":"Article 113041"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145950137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-10DOI: 10.1016/j.injury.2026.113036
Huhu Wang , Hongying He , Jianwen Zhao , Li Han , Weidong Shi , Zhuo Wu , Lin Yang , Wenxing Han , Hao Wang , Shaoguang Li , Xiaowei Zhang , Jianzheng Zhang
<div><h3>Background</h3><div>Bone infection with large bone defects presents a significant challenge for orthopedic surgeons. Free vascularized fibula grafting (FVFG) and the Masquelet technique have proven to be a practical reconstructive approach for addressing large bone defects. Although various strategies have been utilized to manage bone infection with large bone defects, there remains debate concerning the optimal treatment approach. The aim of this study was to observe the outcomes of a new surgical procedure of the modified Masquelet technique for bone infection with large bone defects.</div></div><div><h3>Methods</h3><div>From October 2021 to October 2023, 10 patients of bone infection with large bone defects underwent the surgery of the modified Masquelet technique. A large bone defect was defined as bone defects >6 cm. Among the 10 cases, 8 were male, and 2 were female, with a mean age of 54.7 ± 11.1 years. The median and interquartile range of the infection history was 6 (2, 66) months. The infected skeletal sites included 7 cases in the tibia and 3 in the femur. All cases underwent the modified Masquelet technique, which included two-stage surgical approaches: the first-stage surgery (FSS) involved debridement, bone cement filling, soft tissue coverage, and external fixation; the second-stage surgery (SSS) included removal of the bone cement, FVFG, iliac bone grafting, and external fixation. The bone defect sizes ranging from 9.7 to 22.4 cm (16.4 ± 4.1 cm). The median and quartile of the bone defect volume were 70.1 (52.1, 139.9) cm<sup>3</sup>. The size of the vascularized fibula varied from 11.3 to 21.0 cm (17.2 ± 3.7 cm). Postoperatively, patients were followed for a duration ranging from 12 to 31 (19.7 ± 6.4) months. Bone graft fusion was assessed according to the radiographic union score (RUS), with scores greater than 8 indicating successful bone fusion. The pain was measured by the visual analogue scale (VAS), limb function was assessed with the lower extremity functional scale (LEFS), and anxiety levels were evaluated using the self-rating anxiety scale (SAS).</div></div><div><h3>Results</h3><div>All patients achieved complete resolution of their infections, resulting in an infection cure rate of 100%, with no recurrences observed during the follow-up period. All patients achieved osseous fusion, resulting in an overall bony union rate of 100%. The average RUS recorded was 10.6 ± 1.5, and no instances of re-fracture were observed during the follow-up period. There were no wound-related complications at the donor site of the fibula graft, nor were there any issues such as toe flexion weakness, ankle instability, or pain. Compared with the preoperative scores, the last follow-up VAS scores (0.6 ± 0.5 vs. 5.8 ± 1.0, <em>p</em> < 0.001) and SAS scores (33.3 ± 2.3 vs. 59.7 ± 4.1, <em>p</em> < 0.001) were significantly lower. Compared with the preoperative scores, the last follow-up LEFS scores (63.3 ± 7.8 vs. 20.8 ± 3.8,
{"title":"Modified Masquelet technique using free vascularized fibula grafting for reconstruction of large bone defects after bone infection","authors":"Huhu Wang , Hongying He , Jianwen Zhao , Li Han , Weidong Shi , Zhuo Wu , Lin Yang , Wenxing Han , Hao Wang , Shaoguang Li , Xiaowei Zhang , Jianzheng Zhang","doi":"10.1016/j.injury.2026.113036","DOIUrl":"10.1016/j.injury.2026.113036","url":null,"abstract":"<div><h3>Background</h3><div>Bone infection with large bone defects presents a significant challenge for orthopedic surgeons. Free vascularized fibula grafting (FVFG) and the Masquelet technique have proven to be a practical reconstructive approach for addressing large bone defects. Although various strategies have been utilized to manage bone infection with large bone defects, there remains debate concerning the optimal treatment approach. The aim of this study was to observe the outcomes of a new surgical procedure of the modified Masquelet technique for bone infection with large bone defects.</div></div><div><h3>Methods</h3><div>From October 2021 to October 2023, 10 patients of bone infection with large bone defects underwent the surgery of the modified Masquelet technique. A large bone defect was defined as bone defects >6 cm. Among the 10 cases, 8 were male, and 2 were female, with a mean age of 54.7 ± 11.1 years. The median and interquartile range of the infection history was 6 (2, 66) months. The infected skeletal sites included 7 cases in the tibia and 3 in the femur. All cases underwent the modified Masquelet technique, which included two-stage surgical approaches: the first-stage surgery (FSS) involved debridement, bone cement filling, soft tissue coverage, and external fixation; the second-stage surgery (SSS) included removal of the bone cement, FVFG, iliac bone grafting, and external fixation. The bone defect sizes ranging from 9.7 to 22.4 cm (16.4 ± 4.1 cm). The median and quartile of the bone defect volume were 70.1 (52.1, 139.9) cm<sup>3</sup>. The size of the vascularized fibula varied from 11.3 to 21.0 cm (17.2 ± 3.7 cm). Postoperatively, patients were followed for a duration ranging from 12 to 31 (19.7 ± 6.4) months. Bone graft fusion was assessed according to the radiographic union score (RUS), with scores greater than 8 indicating successful bone fusion. The pain was measured by the visual analogue scale (VAS), limb function was assessed with the lower extremity functional scale (LEFS), and anxiety levels were evaluated using the self-rating anxiety scale (SAS).</div></div><div><h3>Results</h3><div>All patients achieved complete resolution of their infections, resulting in an infection cure rate of 100%, with no recurrences observed during the follow-up period. All patients achieved osseous fusion, resulting in an overall bony union rate of 100%. The average RUS recorded was 10.6 ± 1.5, and no instances of re-fracture were observed during the follow-up period. There were no wound-related complications at the donor site of the fibula graft, nor were there any issues such as toe flexion weakness, ankle instability, or pain. Compared with the preoperative scores, the last follow-up VAS scores (0.6 ± 0.5 vs. 5.8 ± 1.0, <em>p</em> < 0.001) and SAS scores (33.3 ± 2.3 vs. 59.7 ± 4.1, <em>p</em> < 0.001) were significantly lower. Compared with the preoperative scores, the last follow-up LEFS scores (63.3 ± 7.8 vs. 20.8 ± 3.8,","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 3","pages":"Article 113036"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145950138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-14DOI: 10.1016/j.injury.2026.113042
Lorena Cogliatti , Werner Vach , Christoph J. Zech , Henrik Eckardt
Background
Fragility fractures of the pelvis (FFP) are increasingly common, particularly in the ageing population. Traditionally, those low-energy pelvic ring fractures have been managed conservatively, but this approach can lead to immobility and therefore complications. Surgical intervention is indicated based on various factors including type of fracture, mobility, and pain. Minimal-invasive percutaneous sacroiliac and/or transsacral screw stabilisation offers an effective treatment, enabling immediate mobilisation. There are multiple technical methods for the implantation. This study aimed to assess the precision of CT-guided percutaneous screw stabilisation and functional outcomes in elderly patients with FFP.
Methods
A retrospective analysis was conducted on 114 elderly patients who underwent CT-controlled percutaneous sacroiliac screw implantation for FFP between 2010 and 2021. Data on demographics, pre-operative characteristics, surgical procedure, and postoperative outcomes were collected from routine data and analysed.
Results
Stabilisation using CT-guidance demonstrated favourable outcomes with low rates of screw malposition. 96% of the sacroiliac screws in S1 were placed completely intraosseous. Sacroiliac placement showed higher rates of completely intraosseous placement than transsacral placement. Placement in S1 showed higher accuracy rates than placement in S2. Operations with more radiation had a higher percentage of perfectly positioned screws and the simple fracture type had more perfectly positioned screws than the more complex type FFP4. Eighteen screws showed signs of loosening after one year, necessitating re-operation in 2 cases. Patients with 3 screws had less risk of loosening. Screws inserted from the left showed lower rates of loosening than screws from the right. Postoperative mobility assessment showed that 70% were still living at home after one year and 63% were painfree. The one-year mortality was 18%.
Conclusion
CT-guided implantation of 231 sacrum screws had a very high precision with no malpositioned screws. The precision of implantation is not affected by the BMI or age of the patient, but the rate of perfect position was lower in complex fractures than in simple fractures. Precision of sacroiliac screw implantation is higher than that of transsacral screws but the rate of loosening is not higher. Surgery provided freedom from pain for most patients and only few patients lost their self-dependence.
{"title":"The precision of CT-guided percutaneous sacral screw placement in 114 fragility fractures of the pelvis – a retrospective study","authors":"Lorena Cogliatti , Werner Vach , Christoph J. Zech , Henrik Eckardt","doi":"10.1016/j.injury.2026.113042","DOIUrl":"10.1016/j.injury.2026.113042","url":null,"abstract":"<div><h3>Background</h3><div>Fragility fractures of the pelvis (FFP) are increasingly common, particularly in the ageing population. Traditionally, those low-energy pelvic ring fractures have been managed conservatively, but this approach can lead to immobility and therefore complications. Surgical intervention is indicated based on various factors including type of fracture, mobility, and pain. Minimal-invasive percutaneous sacroiliac and/or transsacral screw stabilisation offers an effective treatment, enabling immediate mobilisation. There are multiple technical methods for the implantation. This study aimed to assess the precision of CT-guided percutaneous screw stabilisation and functional outcomes in elderly patients with FFP.</div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted on 114 elderly patients who underwent CT-controlled percutaneous sacroiliac screw implantation for FFP between 2010 and 2021. Data on demographics, pre-operative characteristics, surgical procedure, and postoperative outcomes were collected from routine data and analysed.</div></div><div><h3>Results</h3><div>Stabilisation using CT-guidance demonstrated favourable outcomes with low rates of screw malposition. 96% of the sacroiliac screws in S1 were placed completely intraosseous. Sacroiliac placement showed higher rates of completely intraosseous placement than transsacral placement. Placement in S1 showed higher accuracy rates than placement in S2. Operations with more radiation had a higher percentage of perfectly positioned screws and the simple fracture type had more perfectly positioned screws than the more complex type FFP4. Eighteen screws showed signs of loosening after one year, necessitating re-operation in 2 cases. Patients with 3 screws had less risk of loosening. Screws inserted from the left showed lower rates of loosening than screws from the right. Postoperative mobility assessment showed that 70% were still living at home after one year and 63% were painfree. The one-year mortality was 18%.</div></div><div><h3>Conclusion</h3><div>CT-guided implantation of 231 sacrum screws had a very high precision with no malpositioned screws. The precision of implantation is not affected by the BMI or age of the patient, but the rate of perfect position was lower in complex fractures than in simple fractures. Precision of sacroiliac screw implantation is higher than that of transsacral screws but the rate of loosening is not higher. Surgery provided freedom from pain for most patients and only few patients lost their self-dependence.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 3","pages":"Article 113042"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Trauma results in approximately 1.19 million deaths and 20–50 million disabilities globally each year. With increasing industrialization, road traffic injuries have become a leading cause of Disability Adjusted Life Years and traumatic amputations. These sudden amputations often lead to significant psychological distress. This study aims to assess the effectiveness of psychosocial interventions in enhancing the Quality of Life of post-traumatic amputees.
Material and Methods
This randomized controlled trial enrolled 74 post-traumatic extremity amputees aged over 18 years, who were cognitively coherent, had adequate social support, and no prior psychological illness. Following baseline psychosocial assessment, participants were randomly assigned to two groups: Group A (n = 39) received conventional care, while Group B (n = 35) received both psychosocial intervention and conventional care for seven weeks. Psychosocial outcomes were reassessed in both groups at the eighth week post-intervention.
Results
Quality of life showed significant improvement in both the groups. However, there was no significant difference between the groups. Level of depression, anxiety and stress significantly decreased in both the groups at 8 weeks, but the difference was not significant between the groups. However, body image showed a significant improvement in Group B as compared to Group A (p = 0.023).
Conclusion
Our study did not show any observable positive effects of psychosocial intervention over conventional care on quality of life, depression, stress, or anxiety except on body image. We hypothesize that positive results might be seen in quality of life of amputees if a larger study with longer duration of psychosocial intervention is conducted.
{"title":"Impact of Psychosocial intervention on Quality of life in patients with post- traumatic limb amputation/s: a randomized controlled trial","authors":"Milandeep , Rajesh Sagar , Sushma Sagar , Pratyusha Priyadarshini , Abhinav Kumar , Junaid Alam , Dinesh Bagaria , Narendra Chaudhary , Amit Gupta , Biplab Mishra , Anamika Sahu , Shivam Pandey , Subodh Kumar","doi":"10.1016/j.injury.2026.113027","DOIUrl":"10.1016/j.injury.2026.113027","url":null,"abstract":"<div><h3>Introduction</h3><div>Trauma results in approximately 1.19 million deaths and 20–50 million disabilities globally each year. With increasing industrialization, road traffic injuries have become a leading cause of Disability Adjusted Life Years and traumatic amputations. These sudden amputations often lead to significant psychological distress. This study aims to assess the effectiveness of psychosocial interventions in enhancing the Quality of Life of post-traumatic amputees.</div></div><div><h3>Material and Methods</h3><div>This randomized controlled trial enrolled 74 post-traumatic extremity amputees aged over 18 years, who were cognitively coherent, had adequate social support, and no prior psychological illness. Following baseline psychosocial assessment, participants were randomly assigned to two groups: Group A (<em>n</em> = 39) received conventional care, while Group B (<em>n</em> = 35) received both psychosocial intervention and conventional care for seven weeks. Psychosocial outcomes were reassessed in both groups at the eighth week post-intervention.</div></div><div><h3>Results</h3><div>Quality of life showed significant improvement in both the groups. However, there was no significant difference between the groups. Level of depression, anxiety and stress significantly decreased in both the groups at 8 weeks, but the difference was not significant between the groups. However, body image showed a significant improvement in Group B as compared to Group A (<em>p</em> = 0.023).</div></div><div><h3>Conclusion</h3><div>Our study did not show any observable positive effects of psychosocial intervention over conventional care on quality of life, depression, stress, or anxiety except on body image. We hypothesize that positive results might be seen in quality of life of amputees if a larger study with longer duration of psychosocial intervention is conducted.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 3","pages":"Article 113027"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2026-01-11DOI: 10.1016/j.injury.2026.113039
Yue Tang , Shaofeng Yan , Shudong Jiang , Jonathan Thomas Elliott , Xu Cao , Lillian A. Fisher , Chelsey L. Recendez , Eric R. Henderson , Leah Gitajn
Background
Acute Compartment Syndrome (ACS) is a severe condition that can threaten limb viability, particularly in patients who experience prolonged immobility, such as in the found-down phenomenon. Inadequate removal of nonviable muscle after fasciotomy increases the risk of infection. While non-invasive imaging modalities have been explored for early ACS diagnosis, no tools currently exist to guide precise debridement intraoperatively. Existing technologies are limited by susceptibility to interference, lack of standardized thresholds and insufficient real-time surgical utility. This study aimed to evaluate the association between muscle perfusion, quantified by indocyanine green (ICG)-based dynamic contrast-enhanced fluorescence imaging (DCE-FI), and the degree of muscle necrosis in ACS, assessed via histopathological analysis, to explore the potential of DCE-FI to guide intraoperative muscle debridement.
Methods
A total of 15 adults (aged 18 years or older) undergoing ACS surgical treatment were included in this study between 2023 and 2024. DCE-FI imaging was performed and eight muscle specimens spanning the entire length of the incision were obtained for each patient. Necrosis percentage was assigned to each sample based on histopathological evaluation by a pathologist. Patients were then classified into high necrosis (HN) and low necrosis (LN) groups based on their average necrosis scores from these eight samples, using 50 % necrosis as a cutoff. Perfusion-related kinetic parameters derived from DCE-FI, including maximum fluorescence intensity (Imax) and blood flow (BF), were evaluated and compared between the two groups.
Results
The HN group exhibited significantly lower Imax (p < 0.001) and BF (p < 0.001), compared to those in the LN group, indicating substantially reduced muscle perfusion. The HN group had significantly lower median values (Imax 23.0 RFUs, BF 1.9 mL/min/100g) compared to the LN group (Imax 32.4 RFUs, BF 3.1 mL/min/100g).
Conclusions
ICG-based DCE-FI demonstrated strong potential for intraoperative identification of muscle damage resulting from ACS. This technique may serve as a valuable adjunct for guiding surgical debridement which may minimize complications and reduce the number of debridement procedures required, particularly in challenging cases of delayed or missed diagnosis of compartment syndrome.
{"title":"ICG-based fluorescence imaging to assess muscle perfusion for guiding surgical debridement after acute compartment syndrome","authors":"Yue Tang , Shaofeng Yan , Shudong Jiang , Jonathan Thomas Elliott , Xu Cao , Lillian A. Fisher , Chelsey L. Recendez , Eric R. Henderson , Leah Gitajn","doi":"10.1016/j.injury.2026.113039","DOIUrl":"10.1016/j.injury.2026.113039","url":null,"abstract":"<div><h3>Background</h3><div>Acute Compartment Syndrome (ACS) is a severe condition that can threaten limb viability, particularly in patients who experience prolonged immobility, such as in the found-down phenomenon. Inadequate removal of nonviable muscle after fasciotomy increases the risk of infection. While non-invasive imaging modalities have been explored for early ACS diagnosis, no tools currently exist to guide precise debridement intraoperatively. Existing technologies are limited by susceptibility to interference, lack of standardized thresholds and insufficient real-time surgical utility. This study aimed to evaluate the association between muscle perfusion, quantified by indocyanine green (ICG)-based dynamic contrast-enhanced fluorescence imaging (DCE-FI), and the degree of muscle necrosis in ACS, assessed via histopathological analysis, to explore the potential of DCE-FI to guide intraoperative muscle debridement.</div></div><div><h3>Methods</h3><div>A total of 15 adults (aged 18 years or older) undergoing ACS surgical treatment were included in this study between 2023 and 2024. DCE-FI imaging was performed and eight muscle specimens spanning the entire length of the incision were obtained for each patient. Necrosis percentage was assigned to each sample based on histopathological evaluation by a pathologist. Patients were then classified into high necrosis (HN) and low necrosis (LN) groups based on their average necrosis scores from these eight samples, using 50 % necrosis as a cutoff. Perfusion-related kinetic parameters derived from DCE-FI, including maximum fluorescence intensity (<em>I<sub>max</sub></em>) and blood flow (<em>BF</em>), were evaluated and compared between the two groups.</div></div><div><h3>Results</h3><div>The HN group exhibited significantly lower <em>I<sub>max</sub></em> (<em>p</em> < 0.001) and <em>BF</em> (<em>p</em> < 0.001), compared to those in the LN group, indicating substantially reduced muscle perfusion. The HN group had significantly lower median values (<em>I<sub>max</sub></em> 23.0 RFUs, <em>BF</em> 1.9 mL/min/100g) compared to the LN group (<em>I<sub>max</sub></em> 32.4 RFUs, <em>BF</em> 3.1 mL/min/100g).</div></div><div><h3>Conclusions</h3><div>ICG-based DCE-FI demonstrated strong potential for intraoperative identification of muscle damage resulting from ACS. This technique may serve as a valuable adjunct for guiding surgical debridement which may minimize complications and reduce the number of debridement procedures required, particularly in challenging cases of delayed or missed diagnosis of compartment syndrome.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 3","pages":"Article 113039"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146000122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-01Epub Date: 2025-11-01DOI: 10.1016/j.injury.2025.112868
Yanbin Xue , Linghui Tao
We commend Bassa et al.'s study on VTE risk in acute SCI patients. We propose further exploring rehabilitation strategies, genetic polymorphisms (e.g., factor V Leiden), and inflammatory markers (e.g., CRP, IL-6) to refine personalized VTE prophylaxis and management in this population.
{"title":"Letter to the Editor: Exploring venous thromboembolism (VTE) risk in patients with acute spinal cord injury (SCI)","authors":"Yanbin Xue , Linghui Tao","doi":"10.1016/j.injury.2025.112868","DOIUrl":"10.1016/j.injury.2025.112868","url":null,"abstract":"<div><div>We commend Bassa et al.'s study on VTE risk in acute SCI patients. We propose further exploring rehabilitation strategies, genetic polymorphisms (e.g., factor V Leiden), and inflammatory markers (e.g., CRP, IL-6) to refine personalized VTE prophylaxis and management in this population.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 3","pages":"Article 112868"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145460928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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