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Updated literature review of distal locking techniques for long femoral nails: Advantages and disadvantages 股骨长钉远端锁定技术的最新文献综述:优点和缺点。
IF 2 3区 医学 Q3 CRITICAL CARE MEDICINE Pub Date : 2026-03-01 Epub Date: 2026-01-23 DOI: 10.1016/j.injury.2026.113063
Ollagnon Stella, Maszelin Benjamin, Hamcha Hamid, Pries Pierre, Lacroix Richard, Marty Diloy Thibault, Vendeuvre Tanguy

Introduction

Distal locking during intramedullary femoral nailing remains a technically demanding and radiation-intensive procedure. Since the last systematic review by Whatling et al., numerous innovations over the past two decades have aimed to improve accuracy, shorten operative time, reduce radiation exposure, and simplify the learning curve. A comprehensive synthesis of available techniques is lacking in the recent literature.

Methods

A systematic review was conducted, according to PRISMA guidelines, including all studies published between January 2006 and January 2025 that reported on distal locking techniques for femoral intramedullary nails. Five databases (PubMed, Cochrane, Embase, Web of Science, Google Scholar) were screened using predefined keywords. Data were extracted on technique type, associated advantages and disadvantages, operative time, radiation exposure, accuracy, and complication rates. Risk of bias was assessed using RoB 2, ROBINS-I, JBI, NOS, and ROBIS as appropriate. PROSPERO registration: CRD42025626521

Results

Thirty-six studies met the inclusion criteria, covering several categories: fluoroscopy-free techniques, modification of traditional freehand, targeting devices, and navigation-assisted systems (electromagnetic, robotic, optical, laser-guided). Low-tech solutions such as the “nail-over-nail” or auditory-guided techniques demonstrated promising accuracy in low-resource settings but lacked standardization. Meta-analyses confirmed the efficacy of electromagnetic navigation systems, particularly in reducing radiation exposure and operative time, without compromising success rates. Overall, navigation-based systems showed significant reductions in radiation time and promising accuracy across multiple trials.

Conclusion

This review highlights the broad spectrum of available distal locking techniques, from conventional approaches to advanced technological solutions. Navigation-assisted systems offer measurable benefits but remain limited by cost and accessibility. Simpler mechanical or acoustic methods remain relevant alternatives in specific contexts. No universal gold standard currently exists that can fully replace “freehand technique”. Technique selection should be guided by clinical context, surgeon experience, and available resources. Ultimately, technique adoption will depend on clinical context, available resources, and surgeon familiarity.
导读:股骨髓内钉中的远端锁定仍然是一个技术要求高和辐射密集的手术。自上次由Whatling等人进行的系统综述以来,在过去的二十年中,许多创新旨在提高准确性,缩短手术时间,减少辐射暴露,简化学习曲线。在最近的文献中缺乏对可用技术的全面综合。方法:根据PRISMA指南进行系统回顾,包括2006年1月至2025年1月间发表的关于股骨髓内钉远端锁定技术的所有研究。五个数据库(PubMed, Cochrane, Embase, Web of Science,谷歌Scholar)使用预定义的关键词进行筛选。收集技术类型、相关优缺点、手术时间、放射线暴露、准确性和并发症发生率等数据。采用rob2、ROBINS-I、JBI、NOS和ROBIS评估偏倚风险。结果:36项研究符合纳入标准,涵盖了几个类别:无透视技术、传统徒手改良、靶向装置和导航辅助系统(电磁、机器人、光学、激光制导)。低技术含量的解决方案,如“钉子上钉”或听觉引导技术,在低资源环境下显示出有希望的准确性,但缺乏标准化。荟萃分析证实了电磁导航系统的有效性,特别是在减少辐射暴露和手术时间方面,而且不影响成功率。总体而言,基于导航的系统在多次试验中显示出辐射时间的显著减少和准确性。结论:本综述强调了广泛的远端锁定技术,从传统的方法到先进的技术解决方案。导航辅助系统提供了可衡量的效益,但仍然受到成本和可及性的限制。在特定情况下,更简单的机械或声学方法仍然是相关的选择。目前还没有一个通用的黄金标准可以完全取代“写意技法”。技术选择应根据临床情况、外科医生经验和可用资源进行指导。最终,技术的采用将取决于临床环境、可用资源和外科医生的熟悉程度。
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引用次数: 0
Ultrasound in acute compartment syndrome of the extremities 四肢急性筋膜室综合征的超声诊断。
IF 2 3区 医学 Q3 CRITICAL CARE MEDICINE Pub Date : 2026-03-01 Epub Date: 2026-01-23 DOI: 10.1016/j.injury.2026.113059
Kallin Austin, Marco Trevino, Brody Harn, Eric Liou, Matthew Hazel, Lara Laughrey, Amie Mower
Acute compartment syndrome (ACS) is a surgical emergency that remains challenging to diagnose. Diagnosis is primarily clinical, with invasive intracompartmental pressure (ICP) monitoring recommended when available. However, clinical findings can be unreliable, and invasive ICP measurement carries procedural risks. Ultrasound has increasingly been investigated as a noninvasive diagnostic method for ACS. This review analyzed all reported uses of ultrasound in the context of ACS. Six primary ultrasound techniques were identified: conventional two-dimensional (2D) ultrasound, Doppler ultrasound, pulse phase-locked loop (PPLL) ultrasound, contrast-enhanced ultrasound (CEUS), pressure-related ultrasound (PrUS), and shear-wave elastography (SWE). Each method was described according to its mechanism and theoretical basis, then evaluated for its current clinical relevance. SWE appeared to hold the greatest promise for clinical implementation, with additional potential noted for Doppler ultrasound and tibial fascia angle (TFA) measurements. PrUS, CEUS, and PPLL showed practical limitations that currently restrict clinical application, though further research may address these concerns. Ultrasound offers a noninvasive, repeatable means of quantitatively assessing multiple compartments without the pain or infection risk associated with invasive ICP monitoring. While several methods demonstrate promise, none have yet been validated for clinical adoption. Larger, standardized clinical trials are needed to confirm their diagnostic accuracy and utility.
急性筋膜室综合征(ACS)是一种外科急症,诊断仍然具有挑战性。诊断主要是临床,有创性室内压(ICP)监测时建议。然而,临床结果可能不可靠,侵入性ICP测量有操作风险。超声作为一种无创诊断ACS的方法已得到越来越多的研究。本综述分析了所有报道的超声在ACS背景下的应用。确定了六种主要的超声技术:常规二维(2D)超声、多普勒超声、脉冲锁相环(PPLL)超声、对比增强超声(CEUS)、压力相关超声(PrUS)和剪切波弹性成像(SWE)。根据其机制和理论基础对每种方法进行描述,然后评估其当前的临床相关性。SWE似乎在临床应用中具有最大的希望,在多普勒超声和胫骨筋膜角度(TFA)测量中具有额外的潜力。PrUS, CEUS和PPLL显示出实际的局限性,目前限制了临床应用,尽管进一步的研究可能会解决这些问题。超声提供了一种非侵入性的、可重复的方法来定量评估多个腔室,而没有与侵入性ICP监测相关的疼痛或感染风险。虽然有几种方法显示出希望,但尚未有一种方法被临床采用。需要更大规模、标准化的临床试验来证实其诊断的准确性和实用性。
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引用次数: 0
Prevalence of dysmorphic sacral features in the general population 一般人群中骶骨畸形的患病率
IF 2 3区 医学 Q3 CRITICAL CARE MEDICINE Pub Date : 2026-03-01 Epub Date: 2026-01-10 DOI: 10.1016/j.injury.2026.113048
Ian Meshay , Katelyn A. Cole , Sabrina M. Pescatore , Kaley Haney , John C. Hagedorn II

Background

Posterior pelvic ring injuries, including sacral fractures and sacroiliac (SI) joint disruption, can have potentially serious sequelae and are becoming increasingly common. Management, especially in the setting of instability, consists of internal fixation to decrease the risk of complications. Placement of SI screws requires a thorough knowledge of normal pelvic anatomy and the available osseous fixation pathways. The aim of this study was to define the prevalence of individual features of sacral dysmorphism in the general population.

Methods

We conducted a retrospective review of standard and 3D-reconstructed computed tomography (CT) images of the pelvis to record the presence or absence of each dysmorphic feature. All adult trauma patients who presented within a 5-year period at a single, academic, Level I trauma center were eligible for inclusion. Patients <18 years of age, without advanced pelvic imaging, or who presented with any current or prior pelvic ring injury, tumor, or instrumentation were excluded. The prevalence of each dysmorphic feature was calculated and associations between dysmorphism and demographic factors were investigated.

Results

A total of 2667 patients were eligible for inclusion and the first 1000 were selected for review. Six subjects were excluded during review of CT images. One or more dysmorphic feature was seen in 96.8% of subjects. Each subject displayed an average of 2.7 abnormal features. Residual S1 discs were the most prevalent feature (72.2%). While tongue-in-groove (TIG) sacroiliac (SI) joints were the rarest (7.7% prevalence), they were associated with a significantly higher average number of concurrent dysmorphic features (3.29, P < .0001). Demographic subgroup analysis demonstrated a significantly higher prevalence of S1 discs (P = .0007), TIG SI joints (P < .0001), and colinear upper sacra (P < .0001) in women. Residual S1 discs were also significantly more common in White patients (P < .0001).

Conclusions

Sacral anatomy exists on a spectrum from normal to dysmorphic. This study demonstrates that completely “normal” sacral morphology is seen in <4% of patients. TIG sacroiliac joints may serve as a quick indicator for a higher degree of dysmorphism which may complicate or preclude transiliac-transsacral screw placement.
骨盆后环损伤,包括骶骨骨折和骶髂(SI)关节断裂,可能有潜在的严重后遗症,并且变得越来越普遍。治疗,特别是在不稳定的情况下,包括内固定以减少并发症的风险。放置SI螺钉需要对正常骨盆解剖和可用的骨固定途径有全面的了解。本研究的目的是确定一般人群中骶骨畸形的个体特征的患病率。方法回顾性分析骨盆的标准和三维重建CT图像,记录每种畸形特征的存在或不存在。所有5年内在单一学术一级创伤中心就诊的成人创伤患者均符合入选条件。排除年龄在18岁,没有盆腔显像,或目前或既往有盆腔环损伤、肿瘤或内固定的患者。计算了每种畸形特征的患病率,并调查了畸形与人口因素之间的关系。结果共有2667例患者符合纳入条件,前1000例患者入选。6名受试者在复查CT图像时被排除在外。96.8%的受试者出现一个或多个畸形特征。每个受试者平均表现出2.7个异常特征。残余S1椎间盘是最常见的特征(72.2%)。虽然舌槽型(TIG)骶髂(SI)关节是最罕见的(患病率为7.7%),但它们与并发畸形特征的平均数量显著增加相关(3.29,P < .0001)。人口统计学亚组分析显示,女性中S1椎间盘(P = 0.0007)、TIG - SI关节(P < 0.0001)和上骶骨共线(P < 0.0001)的患病率明显较高。残余S1椎间盘在白人患者中也更为常见(P < .0001)。结论骶骨解剖存在从正常到畸形的谱系。这项研究表明,在4%的患者中可以看到完全“正常”的骶骨形态。骶髂关节TIG可作为高度畸形的快速指标,这种畸形可能使经髂-经骶螺钉置入复杂化或排除。
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引用次数: 0
Measurement properties of the Knee Injury and Osteoarthritis Outcome Score (KOOS) for patella fractures 髌骨骨折的膝关节损伤和骨关节炎结局评分(oos)的测量特性
IF 2 3区 医学 Q3 CRITICAL CARE MEDICINE Pub Date : 2026-03-01 Epub Date: 2026-01-10 DOI: 10.1016/j.injury.2026.113033
Peter Larsen , Rasmus Jorgensen , Martin Jensen , Soeren Lundbye-Christensen , Rasmus Elsoe

Background

The study aimed to investigate relevance, construct validity, reliability, and responsiveness and estimate the minimal clinically important difference of the Knee Injury and Osteoarthritis Outcome Score (KOOS) to adult patients with patella fractures.

Materials and methods

The study design was a prospective cohort study including patients treated conservatively and surgically following a patella fracture (AO-34). The primary outcome measure was the KOOS. The KOOS was repeated at 14 days, 15 days, six weeks, and finally at six and 12 months. Relevance was evaluated by patients and surgeons ranking of relevance of the 42 items in the KOOS, construct validity by correlation to Eq5d, test-retest reliability by an interclass correlation coefficient, and responsiveness by a priori hypothesis and supplemented by effect size. Furthermore, estimation of minimal clinically important difference (MCID) based on longitudinal confirmatory factor analysis.

Results

Included were 65 patients with a mean age of 63.3 years (range 24 to 89) with 74 % female gender. Results showed an acceptable relevance and construct validity. The test-retest reliability was high for all five subscales, with an interclass correlation coefficient ranging from 0.8 to 0.9. Evaluation of responsiveness showed high correlation to the predefined hypothesis (r < 0.6) and moderate to large effect sizes. The MCID of the KOOS subscales were Pain 7.0 (1.6 - 9.8), Symptoms 7.3 (2.0 - 12.6), ADL11.8 (3.2 - 16.0), Sport/Rec 9.3 (3.4 - 15.3) and QOL 8.8 (6.1 - 17.8).

Conclusion

The Knee Injury and Osteoarthritis Outcome Score (KOOS) showed acceptable relevance, construct validity and responsiveness and high reliability to adult patients with patella fractures.
本研究旨在探讨成年髌骨骨折患者膝关节损伤和骨关节炎结局评分(oos)的相关性、构建效度、信度和反应性,并评估其在临床上的最小重要差异。材料和方法研究设计为前瞻性队列研究,包括髌骨骨折后保守治疗和手术治疗的患者(AO-34)。主要结局指标为kos。分别在第14天、第15天、第6周、最后在第6个月和第12个月进行oos。通过患者和外科医生对kos中42个条目的相关性排序来评估相关性,通过与Eq5d的相关性来评估结构效度,通过类间相关系数来评估重测信度,通过先验假设并辅以效应大小来评估反应性。此外,基于纵向验证性因子分析的最小临床重要差异(MCID)估计。结果纳入65例患者,平均年龄63.3岁(24 ~ 89岁),女性占74%。结果显示了可接受的相关性和结构效度。五个分量表的重测信度均较高,类间相关系数在0.8 ~ 0.9之间。对反应性的评估显示与预先设定的假设高度相关(r < 0.6),并且具有中等到较大的效应量。KOOS亚量表的MCID分别为疼痛7.0(1.6 ~ 9.8)、症状7.3(2.0 ~ 12.6)、ADL11.8(3.2 ~ 16.0)、Sport/Rec 9.3(3.4 ~ 15.3)和QOL 8.8(6.1 ~ 17.8)。结论膝关节损伤与骨关节炎预后评分(oos)对成年髌骨骨折患者具有良好的相关性、结构效度和反应性,可靠性较高。
{"title":"Measurement properties of the Knee Injury and Osteoarthritis Outcome Score (KOOS) for patella fractures","authors":"Peter Larsen ,&nbsp;Rasmus Jorgensen ,&nbsp;Martin Jensen ,&nbsp;Soeren Lundbye-Christensen ,&nbsp;Rasmus Elsoe","doi":"10.1016/j.injury.2026.113033","DOIUrl":"10.1016/j.injury.2026.113033","url":null,"abstract":"<div><h3>Background</h3><div>The study aimed to investigate relevance, construct validity, reliability, and responsiveness and estimate the minimal clinically important difference of the Knee Injury and Osteoarthritis Outcome Score (KOOS) to adult patients with patella fractures.</div></div><div><h3>Materials and methods</h3><div>The study design was a prospective cohort study including patients treated conservatively and surgically following a patella fracture (AO-34). The primary outcome measure was the KOOS. The KOOS was repeated at 14 days, 15 days, six weeks, and finally at six and 12 months. Relevance was evaluated by patients and surgeons ranking of relevance of the 42 items in the KOOS, construct validity by correlation to Eq5d, test-retest reliability by an interclass correlation coefficient, and responsiveness by a priori hypothesis and supplemented by effect size. Furthermore, estimation of minimal clinically important difference (MCID) based on longitudinal confirmatory factor analysis.</div></div><div><h3>Results</h3><div>Included were 65 patients with a mean age of 63.3 years (range 24 to 89) with 74 % female gender. Results showed an acceptable relevance and construct validity. The test-retest reliability was high for all five subscales, with an interclass correlation coefficient ranging from 0.8 to 0.9. Evaluation of responsiveness showed high correlation to the predefined hypothesis (<em>r</em> &lt; 0.6) and moderate to large effect sizes. The MCID of the KOOS subscales were Pain 7.0 (1.6 - 9.8), Symptoms 7.3 (2.0 - 12.6), ADL11.8 (3.2 - 16.0), Sport/Rec 9.3 (3.4 - 15.3) and QOL 8.8 (6.1 - 17.8).</div></div><div><h3>Conclusion</h3><div>The Knee Injury and Osteoarthritis Outcome Score (KOOS) showed acceptable relevance, construct validity and responsiveness and high reliability to adult patients with patella fractures.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 3","pages":"Article 113033"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145981575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Construction and validation of a machine learning model based on clinical indicators: Risk of bloodstream infections in patients with deep second- and third-degree burns 基于临床指标的机器学习模型的构建和验证:深度二度和三度烧伤患者血液感染的风险
IF 2 3区 医学 Q3 CRITICAL CARE MEDICINE Pub Date : 2026-03-01 Epub Date: 2026-01-11 DOI: 10.1016/j.injury.2026.113046
Min Peng , ShaSha Zhang , DongFang Chang

Objective

Patients with deep second- and third-degree burns are at high risk of bloodstream infections (BSIs) due to skin barrier disruption and immune suppression, with poor prognosis. Early risk identification is crucial for improving outcomes. This study aimed to construct and validate a machine learning model using multidimensional clinical indicators to accurately predict BSI risk in such patients.

Methods

A retrospective cohort study enrolled 301 patients with deep second- and third-degree burns (75 with BSIs) from Yongchuan Hospital Affiliated to Chongqing Medical University between January 2020 and January 2025. Multidimensional data on burn characteristics, laboratory indicators, and therapeutic measures were collected within 72 h of admission. After data preprocessing and feature screening, four models were built: logistic regression (LR), support vector machine (SVM), naive Bayes (NB), and back propagation artificial neural network (BP-ANN). Model performance was evaluated via stratified sampling and 5-fold cross-validation.

Results

Eight key predictors were identified: total body surface area, lymphocytes (LYM, most important), platelet crit, total bilirubin, creatinine, C-reactive protein, procalcitonin, and 24-hour rehydration. The BP-ANN model performed best in the test set, with accuracy, recall, precision, F1 value, and AUC all reaching 0.857, good calibration (Hosmer-Lemeshow test, P = 0.142), and significant net benefit in the 0–0.3 risk threshold interval (decision curve analysis). The LR model had an AUC of 0.891 and high generalization stability (0.999) but less balanced indicators. SVM was overfitted (limited practical value), and NB had insufficient generalization (test set AUC=0.775).

Conclusion

The BP-ANN model based on multidimensional clinical indicators accurately predicts BSI risk in patients with deep second- and third-degree burns, with good differentiation, calibration, and clinical utility, providing a reliable tool for early intervention.
目的深二、三度烧伤患者由于皮肤屏障破坏和免疫抑制,是血流感染(bsi)的高危患者,预后较差。早期风险识别对于改善结果至关重要。本研究旨在构建并验证使用多维临床指标的机器学习模型,以准确预测此类患者的BSI风险。方法回顾性队列研究纳入了2020年1月至2025年1月重庆医科大学附属永川医院301例深度二、三度烧伤患者(75例伴有脑损伤)。入院72小时内收集烧伤特征、实验室指标和治疗措施的多维数据。经过数据预处理和特征筛选,建立了逻辑回归(LR)、支持向量机(SVM)、朴素贝叶斯(NB)和反向传播人工神经网络(BP-ANN) 4种模型。通过分层抽样和5次交叉验证来评估模型的性能。结果确定了8个关键预测因子:体表面积、淋巴细胞(LYM,最重要的)、血小板损伤、总胆红素、肌酐、c反应蛋白、降钙素原和24小时补液。BP-ANN模型在测试集中表现最好,准确率、召回率、精密度、F1值和AUC均达到0.857,校正效果好(Hosmer-Lemeshow检验,P = 0.142),在0-0.3风险阈值区间(决策曲线分析)净效益显著。LR模型的AUC为0.891,泛化稳定性较高(0.999),但指标不均衡。SVM过拟合(实用价值有限),NB泛化不足(测试集AUC=0.775)。结论基于多维临床指标的BP-ANN模型能够准确预测深度二、三度烧伤患者的BSI风险,具有良好的鉴别、校准和临床实用性,为早期干预提供了可靠的工具。
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引用次数: 0
Impact of surgical timing on perioperative outcomes after open reduction and internal fixation of periprosthetic proximal femoral fractures 手术时机对股骨近端假体周围骨折切开复位内固定围手术期疗效的影响
IF 2 3区 医学 Q3 CRITICAL CARE MEDICINE Pub Date : 2026-03-01 Epub Date: 2026-01-10 DOI: 10.1016/j.injury.2026.113049
Christopher Lampert, Leon Faust, Tobias Helfen, Carl Neuerburg, Boris Michael Holzapfel, Wolfgang Böcker, Eduardo Suero , Florian Pachmann

Background

Periprosthetic proximal femoral fractures (PPFF) are expected to increase substantially due to demographic changes and the rising number of total hip arthroplasties. While early surgery is clearly recommended for native hip fractures, the optimal timing of surgery for PPFF remains controversial. The present study aimed to evaluate the effect of early versus delayed surgery on perioperative outcomes in patients with PPFF treated by open reduction and internal fixation (ORIF).

Methods

We conducted a retrospective analysis of 110 patients with PPFF who underwent ORIF at a Level 1 trauma center between January 2017 and August 2023. We analyzed the effect of early (within 24 hours) versus delayed (after 24 hours) surgical treatment after admission on the primary outcome measures: surgical and non-surgical complications, reoperation rate, in-hospital mortality, and postoperative immobility. Secondary outcome measures included the duration of surgery, length of hospital stay, and bleeding complications.

Results

Baseline demographics, comorbidities, and fracture patterns were comparable between the groups. No significant differences were observed in surgical (18.2 % vs. 14.6 %; p = 0.622) and non-surgical (27.3 % vs. 27.3 %; p = 0.992) complication rates, length of hospital stay (15.6 ± 13.5 vs. 15.4 ± 8.2 days; p = 0.747), reoperation rates (14.6 % vs. 10.9 %; p = 0.621). In-hospital mortality was low (7.3 % vs. 5.5 %; p = 0.672) and was not affected by the time of surgery. A longer operative time in patients undergoing surgery within 24 hours (150.5 ± 56.6 vs. 115.9 ± 54.6 min; p = 0.001) was not associated with an increase in morbidity or mortality.

Conclusion

Timing of surgical intervention had no impact on perioperative outcomes in patients with PPFF treated with ORIF. However, considering the elderly and frail nature of this patient population, timely surgery should be recommended to enable early mobilization, which is essential for preventing complications and may improve long-term functional outcomes.
背景:由于人口结构的变化和全髋关节置换术数量的增加,股骨近端假体周围骨折(PPFF)预计将大幅增加。虽然早期手术被明确推荐用于治疗先天性髋部骨折,但PPFF的最佳手术时机仍存在争议。本研究旨在评估早期手术与延迟手术对经切开复位内固定(ORIF)治疗的PPFF患者围手术期结局的影响。方法回顾性分析2017年1月至2023年8月在某一级创伤中心接受ORIF治疗的110例PPFF患者。我们分析了入院后早期(24小时内)和延迟(24小时后)手术治疗对主要结局指标的影响:手术和非手术并发症、再手术率、住院死亡率和术后不动。次要结局指标包括手术时间、住院时间和出血并发症。结果两组之间的基线人口统计学、合并症和骨折模式具有可比性。手术(18.2%比14.6%,p = 0.622)和非手术(27.3%比27.3%,p = 0.992)并发症发生率、住院时间(15.6±13.5比15.4±8.2天,p = 0.747)、再手术率(14.6%比10.9%,p = 0.621)差异无统计学意义。住院死亡率较低(7.3%对5.5%;p = 0.672),且不受手术时间的影响。24小时内接受手术的患者手术时间较长(150.5±56.6 vs 115.9±54.6 min; p = 0.001)与发病率或死亡率的增加无关。结论手术干预时机对经ORIF治疗的PPFF患者围手术期预后无影响。然而,考虑到这类患者的年老体弱,应建议及时手术以实现早期活动,这对于预防并发症和改善长期功能预后至关重要。
{"title":"Impact of surgical timing on perioperative outcomes after open reduction and internal fixation of periprosthetic proximal femoral fractures","authors":"Christopher Lampert,&nbsp;Leon Faust,&nbsp;Tobias Helfen,&nbsp;Carl Neuerburg,&nbsp;Boris Michael Holzapfel,&nbsp;Wolfgang Böcker,&nbsp;Eduardo Suero ,&nbsp;Florian Pachmann","doi":"10.1016/j.injury.2026.113049","DOIUrl":"10.1016/j.injury.2026.113049","url":null,"abstract":"<div><h3>Background</h3><div>Periprosthetic proximal femoral fractures (PPFF) are expected to increase substantially due to demographic changes and the rising number of total hip arthroplasties. While early surgery is clearly recommended for native hip fractures, the optimal timing of surgery for PPFF remains controversial. The present study aimed to evaluate the effect of early versus delayed surgery on perioperative outcomes in patients with PPFF treated by open reduction and internal fixation (ORIF).</div></div><div><h3>Methods</h3><div>We conducted a retrospective analysis of 110 patients with PPFF who underwent ORIF at a Level 1 trauma center between January 2017 and August 2023. We analyzed the effect of early (within 24 hours) versus delayed (after 24 hours) surgical treatment after admission on the primary outcome measures: surgical and non-surgical complications, reoperation rate, in-hospital mortality, and postoperative immobility. Secondary outcome measures included the duration of surgery, length of hospital stay, and bleeding complications.</div></div><div><h3>Results</h3><div>Baseline demographics, comorbidities, and fracture patterns were comparable between the groups. No significant differences were observed in surgical (18.2 % vs. 14.6 %; p = 0.622) and non-surgical (27.3 % vs. 27.3 %; p = 0.992) complication rates, length of hospital stay (15.6 ± 13.5 vs. 15.4 ± 8.2 days; p = 0.747), reoperation rates (14.6 % vs. 10.9 %; p = 0.621). In-hospital mortality was low (7.3 % vs. 5.5 %; p = 0.672) and was not affected by the time of surgery. A longer operative time in patients undergoing surgery within 24 hours (150.5 ± 56.6 vs. 115.9 ± 54.6 min; p = 0.001) was not associated with an increase in morbidity or mortality.</div></div><div><h3>Conclusion</h3><div>Timing of surgical intervention had no impact on perioperative outcomes in patients with PPFF treated with ORIF. However, considering the elderly and frail nature of this patient population, timely surgery should be recommended to enable early mobilization, which is essential for preventing complications and may improve long-term functional outcomes.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 3","pages":"Article 113049"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145950139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suture button versus syndesmotic screw fixation in acute ankle fractures with syndesmotic injury: An umbrella review of functional outcomes and clinical relevance based on the minimal clinically important difference 缝合扣与韧带联合螺钉固定治疗伴有韧带联合损伤的急性踝关节骨折:基于最小临床重要差异的功能结局和临床相关性的综述。
IF 2 3区 医学 Q3 CRITICAL CARE MEDICINE Pub Date : 2026-03-01 Epub Date: 2026-01-29 DOI: 10.1016/j.injury.2026.113054
Carmen L. Nieuwenkamp, Jasper Tausendfreund, Tim Schepers

Background

Literature increasingly suggests that suture button (SB) fixation yields higher functional outcome scores, specifically the American Orthopaedic Foot Ankle Society (AOFAS) Ankle-Hindfoot score and the Olerud-Molander Ankle Score (OMAS), compared with syndesmotic screws (SS). This umbrella review evaluates whether these differences extend beyond statistical significance and meet thresholds for clinical relevance, using the Minimal Clinically Important Difference (MCID) as reference standard.

Method

A comprehensive PubMed search identified systematic reviews and meta-analyses published between 2010 and 2025. The methodological quality was assessed using the Joanna Briggs Institute checklist. Reported AOFAS and OMAS outcomes, as well as mean differences between SB and SS fixation, were extracted or independently calculated. These values were evaluated against established MCID ranges (OMAS 7.5–11.4, AOFAS 4.1–7.8), to determine whether statistically significant findings corresponded to clinically meaningful improvements

Results

Nineteen systematic reviews were included, of which fifteen performed a meta-analysis. Across these reviews, SB fixation was reported 18 times to result in statistically higher AOFAS and/or OMAS compared with SS fixation. However, most weighted mean differences fell below the MCID thresholds: in 11 reviews for OMAS and in 12 reviews for the AOFAS did not reach clinical relevance. Only one review reported an OMAS difference within the MCID range, and seven reviews reported AOFAS differences within or above the MCID range. These findings indicate that, although statistically significant results were observed, the corresponding functional gains were generally too small to be clinically meaningful.

Conclusion

While SB fixation often demonstrates superior functional scores relative to SS fixation, these differences seldom exceed established MCID thresholds. The clinical relevance of these improvements therefore remains uncertain. As routine removal of syndesmotic screws is no longer advocated in the contemporary literature, and considering the findings of the present study, one could argue that the cost-effectiveness of using a suture-button in under scrutiny. Future studies should focus on refining MCID values for ankle-specific PROMs and improving methodological rigour in systematic reviews and meta-analyses to better determine whether SB fixation provides a meaningful advantage for patients.
背景:越来越多的文献表明,与韧带联合螺钉(SS)相比,缝合扣(SB)固定具有更高的功能预后评分,特别是美国骨科足踝协会(AOFAS)踝关节-后足评分和Olerud-Molander踝关节评分(OMAS)。本综述使用最小临床重要差异(MCID)作为参考标准,评估这些差异是否超出统计显著性并满足临床相关性的阈值。方法:综合PubMed检索确定了2010年至2025年间发表的系统综述和荟萃分析。使用乔安娜布里格斯研究所的检查表评估方法学质量。报告的AOFAS和OMAS结果,以及SB和SS固定之间的平均差异,被提取或独立计算。根据已建立的MCID范围(OMAS 7.5-11.4, AOFAS 4.1-7.8)对这些值进行评估,以确定统计上显著的发现是否与临床有意义的改善相对应。结果:纳入19项系统综述,其中15项进行了荟萃分析。在这些综述中,与SS固定相比,SB固定18次导致统计学上更高的AOFAS和/或OMAS。然而,大多数加权平均差异低于MCID阈值:在11篇关于OMAS的综述和12篇关于AOFAS的综述中没有达到临床相关性。只有一篇综述报告了在MCID范围内的OMAS差异,七篇综述报告了在MCID范围内或以上的AOFAS差异。这些发现表明,虽然观察到统计上显著的结果,但相应的功能增益通常太小,不具有临床意义。结论:虽然相对于SS固定,SB固定通常表现出更高的功能评分,但这些差异很少超过既定的MCID阈值。因此,这些改善的临床意义仍不确定。由于在当代文献中不再提倡常规去除韧带联合螺钉,并且考虑到本研究的结果,人们可能会认为使用缝合按钮的成本效益需要仔细审查。未来的研究应侧重于完善踝关节特异性prom的MCID值,并在系统评价和荟萃分析中提高方法的严谨性,以更好地确定SB固定是否为患者提供了有意义的优势。
{"title":"Suture button versus syndesmotic screw fixation in acute ankle fractures with syndesmotic injury: An umbrella review of functional outcomes and clinical relevance based on the minimal clinically important difference","authors":"Carmen L. Nieuwenkamp,&nbsp;Jasper Tausendfreund,&nbsp;Tim Schepers","doi":"10.1016/j.injury.2026.113054","DOIUrl":"10.1016/j.injury.2026.113054","url":null,"abstract":"<div><h3>Background</h3><div>Literature increasingly suggests that suture button (SB) fixation yields higher functional outcome scores, specifically the American Orthopaedic Foot Ankle Society (AOFAS) Ankle-Hindfoot score and the Olerud-Molander Ankle Score (OMAS), compared with syndesmotic screws (SS). This umbrella review evaluates whether these differences extend beyond statistical significance and meet thresholds for clinical relevance, using the Minimal Clinically Important Difference (MCID) as reference standard.</div></div><div><h3>Method</h3><div>A comprehensive PubMed search identified systematic reviews and meta-analyses published between 2010 and 2025. The methodological quality was assessed using the Joanna Briggs Institute checklist. Reported AOFAS and OMAS outcomes, as well as mean differences between SB and SS fixation, were extracted or independently calculated. These values were evaluated against established MCID ranges (OMAS 7.5–11.4, AOFAS 4.1–7.8), to determine whether statistically significant findings corresponded to clinically meaningful improvements</div></div><div><h3>Results</h3><div>Nineteen systematic reviews were included, of which fifteen performed a meta-analysis. Across these reviews, SB fixation was reported 18 times to result in statistically higher AOFAS and/or OMAS compared with SS fixation. However, most weighted mean differences fell below the MCID thresholds: in 11 reviews for OMAS and in 12 reviews for the AOFAS did not reach clinical relevance. Only one review reported an OMAS difference within the MCID range, and seven reviews reported AOFAS differences within or above the MCID range. These findings indicate that, although statistically significant results were observed, the corresponding functional gains were generally too small to be clinically meaningful.</div></div><div><h3>Conclusion</h3><div>While SB fixation often demonstrates superior functional scores relative to SS fixation, these differences seldom exceed established MCID thresholds. The clinical relevance of these improvements therefore remains uncertain. As routine removal of syndesmotic screws is no longer advocated in the contemporary literature, and considering the findings of the present study, one could argue that the cost-effectiveness of using a suture-button in under scrutiny. Future studies should focus on refining MCID values for ankle-specific PROMs and improving methodological rigour in systematic reviews and meta-analyses to better determine whether SB fixation provides a meaningful advantage for patients.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 3","pages":"Article 113054"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146121478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to editor regarding “Discordance between surgeon opinion and institutional policy on explant handling after hardware removal” 致编辑关于“外科医生意见与机构政策在硬体移除后外植体处理上的不一致”的信。
IF 2 3区 医学 Q3 CRITICAL CARE MEDICINE Pub Date : 2026-03-01 Epub Date: 2025-10-31 DOI: 10.1016/j.injury.2025.112869
Arman Vahabi, Ali Engin Daştan, Hüseyin Günay, Kemal Aktuğlu
{"title":"Letter to editor regarding “Discordance between surgeon opinion and institutional policy on explant handling after hardware removal”","authors":"Arman Vahabi,&nbsp;Ali Engin Daştan,&nbsp;Hüseyin Günay,&nbsp;Kemal Aktuğlu","doi":"10.1016/j.injury.2025.112869","DOIUrl":"10.1016/j.injury.2025.112869","url":null,"abstract":"","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 3","pages":"Article 112869"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145472569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is percutaneous pelvic fixation becoming more prevalent among new orthopaedic trauma surgeons? - Trends in pelvic ring fixation 经皮骨盆固定术在新的骨科创伤外科医生中越来越普遍吗?-骨盆环固定的趋势
IF 2 3区 医学 Q3 CRITICAL CARE MEDICINE Pub Date : 2026-03-01 Epub Date: 2025-12-17 DOI: 10.1016/j.injury.2025.112960
Thirushan Wignakumar , Devon T. Brameier , Christopher R. Leland , Duco W.P.M. Laane , Annabelle Swenson , Eric H. Tischler , Derek S. Stenquist , Arvind G. Von Keudell , Michael J. Weaver , Nishant Suneja

Introduction

The treatment paradigm of pelvic ring injuries has undulated over recent decades. Open reduction and internal fixation (ORIF) became more common in the 1990s and early 2000s followed by a decline in the late 2000s and 2010s, in favor of nonoperative management. Recently, minimally invasive pelvic stabilization using percutaneous pelvic fixation (PFF) has gained popularity. The trends of ORIF, PPF, and nonoperative management of pelvic ring injuries over the last decade is not well described. This study aims to characterize such trends among early-career orthopaedic trauma surgeons from 2003 to 2023.

Methods

Data was collected from the American Board of Orthopaedic Surgery (ABOS) Part II Oral Examination Case List database for Candidates who indicated that their subspecialty was trauma over a time period involving 20 years of Case List submissions (2003–2023). Pelvic ring fixation was identified using CPT codes for ORIF (27,217, 27,218) and PPF (27,216). Total case volumes and trends in fixation type were analyzed, including an age-based subgroup analysis of younger (age 18–50) and older (age ≥65) adults,

Results

Of 15,164 total ABOS Part II Candidates, 795 indicated a trauma subspecialty and performed at least one pelvic ring fixation, with a total of 7311 pelvic fixation cases (3317 ORIF; 3994 PPF). Annual pelvic ring injury fixations increased five-fold during the study period, from 110 in 2003 to 592 in 2023. The proportion of ORIF decreased from 70 % to 40 %, while PPF increased from 30 % to 60 %. The share of early-career surgeons' practice dedicated to percutaneous fixation tripled. Operative fixation (both PPF and ORIF) of pelvic ring injuries in older adult patients became more common over this period.

Conclusion

Percutaneous stabilization of pelvic ring injuries is increasing over time, reflecting evolving practice patterns among early-career trauma surgeons. Future studies should evaluate the clinical implications of this trend, including the impact on fellow and resident training.
近几十年来,骨盆环损伤的治疗模式起伏不定。切开复位内固定(ORIF)在20世纪90年代和21世纪初变得更加普遍,随后在21世纪后期和2010年代有所下降,有利于非手术治疗。近年来,经皮盆腔内固定术(PFF)的应用越来越广泛。在过去的十年里,骨盆环损伤的ORIF、PPF和非手术治疗的趋势并没有得到很好的描述。本研究旨在描述2003年至2023年早期职业骨科创伤外科医生的这种趋势。方法从美国骨科外科委员会(ABOS)第二部分口腔检查病例列表数据库中收集数据,这些患者表明他们的亚专科是创伤,涉及20年的病例列表提交(2003-2023)。使用ORIF(27,217, 27,218)和PPF(27,216)的CPT代码确定骨盆环固定。分析了总病例量和固定类型的趋势,包括基于年龄的亚组分析,包括年轻(18-50岁)和年长(≥65岁)的成年人。结果在15164名ABOS第二部分候选人中,795名显示创伤亚专科并至少进行了一次骨盆环固定,共有7311例骨盆固定病例(3317例ORIF; 3994例PPF)。在研究期间,每年盆腔环损伤固定增加了5倍,从2003年的110例增加到2023年的592例。ORIF的比例从70%下降到40%,而PPF的比例从30%上升到60%。早期职业外科医生从事经皮固定手术的比例增加了两倍。在此期间,老年患者骨盆环损伤的手术固定(PPF和ORIF)变得更加常见。结论随着时间的推移,经皮骨盆环损伤的稳定越来越多,这反映了早期创伤外科医生的实践模式的变化。未来的研究应评估这一趋势的临床意义,包括对研究员和住院医师培训的影响。
{"title":"Is percutaneous pelvic fixation becoming more prevalent among new orthopaedic trauma surgeons? - Trends in pelvic ring fixation","authors":"Thirushan Wignakumar ,&nbsp;Devon T. Brameier ,&nbsp;Christopher R. Leland ,&nbsp;Duco W.P.M. Laane ,&nbsp;Annabelle Swenson ,&nbsp;Eric H. Tischler ,&nbsp;Derek S. Stenquist ,&nbsp;Arvind G. Von Keudell ,&nbsp;Michael J. Weaver ,&nbsp;Nishant Suneja","doi":"10.1016/j.injury.2025.112960","DOIUrl":"10.1016/j.injury.2025.112960","url":null,"abstract":"<div><h3>Introduction</h3><div>The treatment paradigm of pelvic ring injuries has undulated over recent decades. Open reduction and internal fixation (ORIF) became more common in the 1990s and early 2000s followed by a decline in the late 2000s and 2010s, in favor of nonoperative management. Recently, minimally invasive pelvic stabilization using percutaneous pelvic fixation (PFF) has gained popularity. The trends of ORIF, PPF, and nonoperative management of pelvic ring injuries over the last decade is not well described. This study aims to characterize such trends among early-career orthopaedic trauma surgeons from 2003 to 2023.</div></div><div><h3>Methods</h3><div>Data was collected from the American Board of Orthopaedic Surgery (ABOS) Part II Oral Examination Case List database for Candidates who indicated that their subspecialty was trauma over a time period involving 20 years of Case List submissions (2003–2023). Pelvic ring fixation was identified using CPT codes for ORIF (27,217, 27,218) and PPF (27,216). Total case volumes and trends in fixation type were analyzed, including an age-based subgroup analysis of younger (age 18–50) and older (age ≥65) adults,</div></div><div><h3>Results</h3><div>Of 15,164 total ABOS Part II Candidates, 795 indicated a trauma subspecialty and performed at least one pelvic ring fixation, with a total of 7311 pelvic fixation cases (3317 ORIF; 3994 PPF). Annual pelvic ring injury fixations increased five-fold during the study period, from 110 in 2003 to 592 in 2023. The proportion of ORIF decreased from 70 % to 40 %, while PPF increased from 30 % to 60 %. The share of early-career surgeons' practice dedicated to percutaneous fixation tripled. Operative fixation (both PPF and ORIF) of pelvic ring injuries in older adult patients became more common over this period.</div></div><div><h3>Conclusion</h3><div>Percutaneous stabilization of pelvic ring injuries is increasing over time, reflecting evolving practice patterns among early-career trauma surgeons. Future studies should evaluate the clinical implications of this trend, including the impact on fellow and resident training.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 3","pages":"Article 112960"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145981496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preoperative malnutrition is associated with increased early complications and higher two-year nonunion risk after Tibial shaft fracture fixation 术前营养不良与胫干骨折固定后早期并发症增加和两年不愈合风险增高有关。
IF 2 3区 医学 Q3 CRITICAL CARE MEDICINE Pub Date : 2026-03-01 Epub Date: 2026-01-30 DOI: 10.1016/j.injury.2026.113084
Jawad Saad , David Abdelnour , Magd Boutany , Alqasim Elnaggar , Hadi Elmenini , Ahmad Almaat , Ali Mehaidli , Rahul Vaidya

Background

Malnutrition is a potentially modifiable risk factor that may influence perioperative complications and fracture healing. This study evaluated the association between preoperative laboratory-defined malnutrition and short-term complications and 2-year outcomes following operative fixation of tibial shaft fractures.

Methods

Using the TriNetX Research Network (112 healthcare organizations), adults (≥18 years) undergoing operative management for tibial shaft fracture were identified. Preoperative malnutrition was defined as albumin ≤3.5 g/dL and/or leukocytes ≤1.5 × 10³/µL within 1 year prior to the index event. Cohorts were propensity score matched 1:1 on demographics and comorbidities. Outcomes were assessed from day 1 post-index through 90 days (medical/surgical complications) and 730 days (healing-related and limb outcomes). Risk ratios (RR) and hazard ratios (HR) with 95% confidence intervals (CI) were reported.

Results

After matching, 44,780 patients were included in each cohort (89,560 total), with good balance across covariates (all SMDs <0.10). At 90 days, malnutrition was associated with higher risk of acute respiratory failure/mechanical ventilation (13.9% vs 3.4%; RR 4.10 [95% CI 3.88–4.33].; HR 4.32 [4.09–4.57].), sepsis (5.2% vs 1.2%; RR 4.35 [3.97–4.77].; HR 4.47 [4.07–4.91].), postoperative infection (5.7% vs 1.8%; RR 3.14 [2.90–3.39].; HR 3.23 [2.99–3.50].), acute kidney injury (8.6% vs 3.0%; RR 2.90 [2.73–3.08].; HR 2.99 [2.81–3.18].), and DVT/PE (6.5% vs 2.7%; RR 2.36 [2.21–2.52].; HR 2.42 [2.26–2.59].) (all p < 0.001). At 2 years, malnutrition was associated with increased nonunion (4.4% vs 1.6%; RR 2.69 [2.47–2.92].; HR 2.85 [2.62–3.10].), chronic osteomyelitis (12.5% vs 3.9%; RR 3.19 [3.02–3.36].; HR 3.50 [3.32–3.69].), hardware removal (10.1% vs 6.0%; RR 1.68 [1.61–1.76].; HR 1.83 [1.74–1.92].), and amputation (1.4% vs 0.4%; RR 3.47 [2.95–4.08].; HR 3.59 [3.05–4.23].) (all p < 0.001). Revision fixation did not differ (8.4% vs 8.1%; p = 0.096).

Conclusions

Preoperative laboratory-defined malnutrition was independently associated with substantially higher 90-day morbidity and increased 2-year nonunion and limb-complication risk following operative tibial shaft fracture management. These findings support preoperative nutritional risk stratification and targeted optimization efforts in this population.
背景:营养不良是影响围手术期并发症和骨折愈合的潜在可改变的危险因素。本研究评估了术前实验室定义的营养不良与胫骨干骨折手术固定后短期并发症和2年预后之间的关系。方法:利用TriNetX研究网络(112家医疗机构),对接受胫骨干骨折手术治疗的成人(≥18岁)进行识别。术前营养不良定义为在指标事件发生前1年内白蛋白≤3.5 g/dL和/或白细胞≤1.5 × 10³/µL。队列在人口统计学和合并症上的倾向评分匹配为1:1。结果从指数后第1天到90天(医疗/手术并发症)和730天(愈合相关和肢体结果)进行评估。报告了95%可信区间(CI)的风险比(RR)和危险比(HR)。结果:匹配后,每个队列纳入44,780例患者(共89,560例),各变量之间具有良好的平衡(所有SMDs)。结论:术前实验室定义的营养不良与手术后胫骨骨干骨折治疗后90天发病率显著升高、2年骨不连和肢体并发症风险增加独立相关。这些发现支持术前营养风险分层和有针对性的优化工作。
{"title":"Preoperative malnutrition is associated with increased early complications and higher two-year nonunion risk after Tibial shaft fracture fixation","authors":"Jawad Saad ,&nbsp;David Abdelnour ,&nbsp;Magd Boutany ,&nbsp;Alqasim Elnaggar ,&nbsp;Hadi Elmenini ,&nbsp;Ahmad Almaat ,&nbsp;Ali Mehaidli ,&nbsp;Rahul Vaidya","doi":"10.1016/j.injury.2026.113084","DOIUrl":"10.1016/j.injury.2026.113084","url":null,"abstract":"<div><h3>Background</h3><div>Malnutrition is a potentially modifiable risk factor that may influence perioperative complications and fracture healing. This study evaluated the association between preoperative laboratory-defined malnutrition and short-term complications and 2-year outcomes following operative fixation of tibial shaft fractures.</div></div><div><h3>Methods</h3><div>Using the TriNetX Research Network (112 healthcare organizations), adults (≥18 years) undergoing operative management for tibial shaft fracture were identified. Preoperative malnutrition was defined as albumin ≤3.5 g/dL and/or leukocytes ≤1.5 × 10³/µL within 1 year prior to the index event. Cohorts were propensity score matched 1:1 on demographics and comorbidities. Outcomes were assessed from day 1 post-index through 90 days (medical/surgical complications) and 730 days (healing-related and limb outcomes). Risk ratios (RR) and hazard ratios (HR) with 95% confidence intervals (CI) were reported.</div></div><div><h3>Results</h3><div>After matching, 44,780 patients were included in each cohort (89,560 total), with good balance across covariates (all SMDs &lt;0.10). At 90 days, malnutrition was associated with higher risk of acute respiratory failure/mechanical ventilation (13.9% vs 3.4%; RR 4.10 [95% CI 3.88–4.33].; HR 4.32 [4.09–4.57].), sepsis (5.2% vs 1.2%; RR 4.35 [3.97–4.77].; HR 4.47 [4.07–4.91].), postoperative infection (5.7% vs 1.8%; RR 3.14 [2.90–3.39].; HR 3.23 [2.99–3.50].), acute kidney injury (8.6% vs 3.0%; RR 2.90 [2.73–3.08].; HR 2.99 [2.81–3.18].), and DVT/PE (6.5% vs 2.7%; RR 2.36 [2.21–2.52].; HR 2.42 [2.26–2.59].) (all <em>p</em> &lt; 0.001). At 2 years, malnutrition was associated with increased nonunion (4.4% vs 1.6%; RR 2.69 [2.47–2.92].; HR 2.85 [2.62–3.10].), chronic osteomyelitis (12.5% vs 3.9%; RR 3.19 [3.02–3.36].; HR 3.50 [3.32–3.69].), hardware removal (10.1% vs 6.0%; RR 1.68 [1.61–1.76].; HR 1.83 [1.74–1.92].), and amputation (1.4% vs 0.4%; RR 3.47 [2.95–4.08].; HR 3.59 [3.05–4.23].) (all <em>p</em> &lt; 0.001). Revision fixation did not differ (8.4% vs 8.1%; <em>p</em> = 0.096).</div></div><div><h3>Conclusions</h3><div>Preoperative laboratory-defined malnutrition was independently associated with substantially higher 90-day morbidity and increased 2-year nonunion and limb-complication risk following operative tibial shaft fracture management. These findings support preoperative nutritional risk stratification and targeted optimization efforts in this population.</div></div>","PeriodicalId":54978,"journal":{"name":"Injury-International Journal of the Care of the Injured","volume":"57 3","pages":"Article 113084"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146115232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Injury-International Journal of the Care of the Injured
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