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Correction to “Factors Associated With Depressive Symptoms Among Graduate Students in Science and Technology: A Cross-Sectional Study With Multivariable Analysis” 修正“与理工科研究生抑郁症状相关的因素:一项多变量分析的横断面研究”。
IF 3.3 2区 医学 Q1 PSYCHIATRY Pub Date : 2026-02-22 DOI: 10.1155/da/9786494

S. Chapagai, I. P. Banjade, and S. P. Khanal, “Factors Associated With Depressive Symptoms Among Graduate Students in Science and Technology: A Cross-Sectional Study With Multivariable Analysis,” Depression and Anxiety 2025 (2025): 8886228, https://doi.org/10.1155/da/8886228.

In the article titled, “Factors Associated With Depressive Symptoms Among Graduate Students in Science and Technology: A Cross-Sectional Study With Multivariable Analysis,” there was an error in the article type. The correct article type is Research Article.

We apologize for this error.

[这更正了文章DOI: 10.1155/da/8886228.]。
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引用次数: 0
Correction to “Marital Adjustment as a Mediator Between Emotional Suppression and Self-Compassion in Women Aged 35+ Undergoing In Vitro Fertilization-Embryo Transfer: A Cross-Sectional Observational Study” 修正“婚姻调整在35岁以上体外受精-胚胎移植女性情绪抑制与自我同情之间的中介作用:一项横断面观察研究”。
IF 3.3 2区 医学 Q1 PSYCHIATRY Pub Date : 2026-02-14 DOI: 10.1155/da/9868160

M. Zheng, H. Wang, C. Li, et al., “Marital Adjustment as a Mediator Between Emotional Suppression and Self-Compassion in Women Aged 35+ Undergoing In Vitro Fertilization-Embryo Transfer: A Cross-Sectional Observational Study,” Depression and Anxiety (2025): 2025 2100969, https://doi.org/10.1155/da/2100969.

In the article titled, “Marital Adjustment as a Mediator Between Emotional Suppression and Self-Compassion in Women Aged 35+ Undergoing In Vitro Fertilization-Embryo Transfer: A Cross-Sectional Observational Study,” there was an error in Figure 1. The figure should show with the connecting lines that illustrate the conceptual relationships between variables. The correct Figure 1 is shown below:

We apologize for this error.

[这更正了文章DOI: 10.1155/da/2100969.]。
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引用次数: 0
Semantic Agency Patterns Signal Depressive Experiences: Evidence From Postpartum Communication on Social Media 语义代理模式信号抑郁经验:来自产后社交媒体交流的证据。
IF 3.3 2区 医学 Q1 PSYCHIATRY Pub Date : 2026-02-08 DOI: 10.1155/da/6485997
Marta Witkowska, Marta Beneda, Magdalena Formanowicz, Magda Leszko, Selen Arslan, Jan Nikadon, Joachim Kowalski, Tomaso Erseghe, Caterina Suitner

Depression-related symptoms, such as loss of motivation and diminished interest in activities, correspond to loss of agency. Given recent evidence that agency (or its lack) can be reliably detected in language, we investigated how linguistic manifestations of agency relate to depressive experiences. In two studies, we explored whether semantic agency can serve as a novel marker of depressive experiences within the context of postpartum. We analyzed data from Twitter (Study 1, N = 17,664 tweets) and Reddit (Study 2, N = 3033 posts), using three complementary approaches: machine learning-based topic detection, analysis of established linguistic markers of depression, and expert coding of depressive experiences. Across both studies, reduced semantic agency consistently emerged as a reliable indicator of depressive features. Posts discussing individuals’ depressive experiences in the postpartum period exhibited lower levels of semantic agency; semantic agency within posts was negatively correlated with established linguistic markers of depression; and semantic agency was negatively linked to depressive experiences as coded by experts. These findings highlight the potential of semantic analysis for mental health applications, suggesting that agency-based markers could enrich existing linguistic frameworks examining psychological distress. While this research is at an early stage, future validation could clarify whether such markers might enhance the sensitivity of language-based screening tools for identifying individuals in need of mental health support.

与抑郁相关的症状,如失去动力和对活动的兴趣减弱,对应于能动性的丧失。鉴于最近的证据表明代理(或缺乏代理)可以在语言中可靠地检测到,我们研究了代理的语言表现如何与抑郁体验相关。在两项研究中,我们探讨了语义代理是否可以作为产后抑郁经历的新标记。我们分析了Twitter(研究1,N = 17,664条推文)和Reddit(研究2,N = 3033条帖子)的数据,使用了三种互补的方法:基于机器学习的主题检测、对已建立的抑郁语言标记的分析以及对抑郁经历的专家编码。在这两项研究中,语义代理减少一直是抑郁特征的可靠指标。讨论产后抑郁经历的帖子表现出较低的语义代理水平;帖子内的语义代理与抑郁的既定语言标记负相关;根据专家的编码,语义代理与抑郁经历呈负相关。这些发现强调了语义分析在心理健康应用中的潜力,表明基于行为的标记可以丰富现有的检查心理困扰的语言框架。虽然这项研究还处于早期阶段,但未来的验证可以澄清这些标记是否可以提高基于语言的筛选工具的敏感性,以识别需要心理健康支持的个体。
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引用次数: 0
Error-Related Brain Potentials as Biomarkers of Pathology Severity and Treatment Resistance in Patients With Obsessive-Compulsive Disorder 错误相关脑电位作为强迫症患者病理严重程度和治疗抵抗的生物标志物。
IF 3.3 2区 医学 Q1 PSYCHIATRY Pub Date : 2026-02-06 DOI: 10.1155/da/9694689
Issa Wassouf, Nicolas Vibert, Julien Dampuré, Damien Doolub, Ghina Harika-Germaneau, Nicolas Langbour, Nematollah Jaafari

Obsessive-compulsive disorder (OCD) is a psychiatric condition that varies considerably in severity and resistance to treatment. The aim of this study was to identify error detection abnormalities in OCD patients using evoked potential recordings and to determine whether links could be established between individual patients’ error detection processes and their severity and resistance to treatment. To answer this question, the potentials evoked by participants’ responses to a flanker task, i.e., the error-related negativity (ERN/CRN component) and subsequent positivity (Pe/Pc component), were recorded. Twenty-six OCD patients with a wide range of pathology severity and treatment resistance and 26 control participants matched for gender, age, and education level with the patients were included in the study. The amplitude of the error-related negativity (ERN) evoked by false responses was positively correlated with the severity of patients’ pathology, while the lower the amplitude of the negativity evoked by correct responses (CRN), the more resistant patients were to treatment. The ERN/CRN components could therefore be used as markers of the severity and treatment resistance of OCD patients’ pathology. Furthermore, under the present experimental conditions, the positive Pe/Pc component, supposed to reflect patients’ awareness of the correctness of their responses, was virtually absent compared to control participants. This suggests a major deficit in the patients’ monitoring of the consequences of their actions. The discovery of this disappearance of action feedback signals in patients leads to proposing an original neurodevelopmental model for the onset of pathology in childhood or adolescence.

强迫症(OCD)是一种精神疾病,其严重程度和对治疗的抵抗力各不相同。本研究的目的是利用诱发电位记录来识别强迫症患者的错误检测异常,并确定是否可以在个体患者的错误检测过程与其严重程度和对治疗的抵抗力之间建立联系。为了回答这个问题,我们记录了被试对侧侧任务的反应所引起的电位,即与错误相关的负性(ERN/CRN成分)和随后的正性(Pe/Pc成分)。研究纳入了26例不同病理严重程度和治疗抵抗程度的强迫症患者,以及26例与患者性别、年龄、教育程度相匹配的对照组。错误反应引起的错误相关负性反应(error-related negative, ERN)的振幅与患者的病理严重程度呈正相关,而正确反应引起的负性反应(CRN)的振幅越低,患者对治疗的抵抗力越强。因此,ERN/CRN成分可以作为强迫症患者病理严重程度和治疗耐药性的标志。此外,在目前的实验条件下,与对照组相比,阳性Pe/Pc成分几乎不存在,而Pe/Pc成分本应反映患者对其反应正确性的认识。这表明患者对自己行为后果的监测存在重大缺陷。这种动作反馈信号在患者中消失的发现导致提出了一个原始的儿童或青少年发病的神经发育模型。
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引用次数: 0
Effects of Transdiagnostic Cognitive Behavioural Therapy on Long-Term Quality of Life: A Causal Mediation Analysis Across Anxiety and Depressive Symptoms 跨诊断认知行为治疗对长期生活质量的影响:焦虑和抑郁症状的因果中介分析
IF 3.3 2区 医学 Q1 PSYCHIATRY Pub Date : 2026-02-06 DOI: 10.1155/da/1601969
Gabriel Esteller-Collado, María Carpallo-González, Maider Prieto-Vila, Francisco Jurado-González, Mario Gálvez-Lara, Paloma Ruíz-Rodríguez, César González-Blanch, Juan Antonio Moriana, Antonio Cano-Vindel, Roger Muñoz-Navarro

Introduction

Anxiety and depression significantly impair quality of life (QoL) in primary care (PC) patients. While transdiagnostic cognitive behavioural therapy (TD-CBT) is effective, the mechanisms underlying its long-term impact on QoL remain unclear. This study examined whether changes in anxiety and depressive symptoms mediate the effect of TD-CBT on QoL at 12-month follow-up.

Methods

Data were used from the “Psychology in Primary Care” trial (PsicAP, from its Spanish acronym), which included 1061 PC patients with anxiety and depression, randomised to TD-CBT plus treatment-as-usual (TAU) or TAU alone. Anxiety and depression were assessed at baseline, post-treatment and 6-month follow-up. QoL was measured at baseline and 12-month follow-up. Path analyses using structural equation modelling (SEM) were used to study direct and indirect effects, controlling for baseline scores and gender.

Results

TD-CBT significantly reduced anxiety and depression immediately post-treatment compared to TAU. The only significant indirect effect on 12-month QoL across all dimensions operated sequentially through sustained reductions in depressive symptoms. No significant mediation was found via anxiety symptoms. No specific temporal sequence of symptom improvement mediating QoL was identified.

Discussion

TD-CBT improves anxiety and depressive symptoms at post-treatment; nevertheless, long-term QoL improvement occurs primarily through sustained reduction in depressive symptoms and through the direct effects of treatment itself. These findings support the implementation of TD-CBT in PC to achieve lasting functional recovery, highlighting the crucial role of addressing and sustaining improvements in depression.

焦虑和抑郁显著影响初级保健(PC)患者的生活质量(QoL)。虽然跨诊断认知行为疗法(TD-CBT)是有效的,但其对生活质量的长期影响机制尚不清楚。本研究在12个月的随访中探讨了焦虑和抑郁症状的改变是否介导TD-CBT对生活质量的影响。方法:数据来自“初级保健心理学”试验(PsicAP,来自其西班牙语首字母缩略词),其中包括1061名焦虑和抑郁的PC患者,随机分为TD-CBT加常规治疗(TAU)或单独治疗TAU。在基线、治疗后和6个月的随访中评估焦虑和抑郁。在基线和12个月随访时测量生活质量。使用结构方程模型(SEM)的通径分析来研究直接和间接影响,控制基线得分和性别。结果:与TAU相比,TD-CBT治疗后立即显著减少焦虑和抑郁。在所有维度上对12个月生活质量的唯一显著间接影响是通过抑郁症状的持续减少而依次发生的。焦虑症状未发现显著的调节作用。没有确定症状改善介导生活质量的特定时间序列。讨论:TD-CBT改善治疗后的焦虑和抑郁症状;然而,长期生活质量的改善主要是通过抑郁症状的持续减轻和治疗本身的直接效果来实现的。这些发现支持在PC中实施TD-CBT以实现持久的功能恢复,强调了解决和持续改善抑郁症的关键作用。
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引用次数: 0
Mnemonic Discrimination Performance in Anxiety and Depression: A Systematic Review 记忆辨别在焦虑和抑郁中的表现:系统回顾。
IF 3.3 2区 医学 Q1 PSYCHIATRY Pub Date : 2026-02-04 DOI: 10.1155/da/8826935
Alexandra Kaszás, Szabolcs Kéri

Anxiety disorders and depression are the most frequently diagnosed mental illnesses and are highly comorbid. Both have been linked to memory impairments, albeit the relationship between them remains unclear and understudied. Our review aims to investigate behavioral pattern separation performance in individuals with varying levels of anxiety and depression. We included studies where mnemonic discrimination performance is measured using mnemonic discrimination tasks designed to directly measure behavioral pattern separation, while symptoms of anxiety and/or depression are assessed using any validated and recognized scales or inventories. We only included quantitative studies. Fixed scientific databases and artificial intelligence were systematically searched, identifying nine studies on anxiety and 14 on depression. Anxiety studies presented conflicting evidence, but a trend showed optimal mnemonic discrimination with threat-based encoding and safe retrieval. Conversely, depression studies consistently suggested a negative relationship between symptom severity and pattern separation performance. Additionally, pattern separation appeared enhanced for negative stimuli and impaired for neutral stimuli in individuals with higher levels of depression. However, no clear differences were observed between clinically diagnosed groups and healthy controls. Methodological inconsistencies in anxiety studies present challenges for interpretation. Similarly, the effects of medication and the heterogeneity of clinical groups pose limitations to depression studies. Trends were identified, but further investigation with unified methodologies and clinical groups is needed to understand the relationship between anxiety, depression, and mnemonic discrimination performance.

焦虑症和抑郁症是最常见的精神疾病,并且是高度合并症。两者都与记忆障碍有关,尽管两者之间的关系尚不清楚,也未得到充分研究。本研究旨在探讨不同焦虑和抑郁水平个体的行为模式分离表现。我们纳入了使用旨在直接测量行为模式分离的助记辨别任务来测量助记辨别表现的研究,而使用任何经过验证和认可的量表或清单来评估焦虑和/或抑郁症状。我们只纳入了定量研究。系统地检索了固定的科学数据库和人工智能,确定了9项关于焦虑的研究和14项关于抑郁的研究。焦虑研究提供了相互矛盾的证据,但一个趋势是基于威胁的编码和安全检索的助记识别效果最佳。相反,抑郁症研究一致表明,症状严重程度与模式分离表现之间存在负相关关系。此外,抑郁程度高的个体对消极刺激的模式分离能力增强,对中性刺激的模式分离能力受损。然而,在临床诊断组和健康对照组之间没有明显差异。焦虑研究中方法的不一致性为解释提出了挑战。同样,药物的效果和临床群体的异质性也限制了抑郁症的研究。趋势已经确定,但需要进一步研究统一的方法和临床群体来了解焦虑、抑郁和助记辨别表现之间的关系。
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引用次数: 0
Correction to “A Systematic Review of Factors Associated With Treatment Engagement and Outcome for Women in the Perinatal Period Receiving Individual Cognitive Behavioral Therapy (CBT) for Depression, Anxiety, and Trauma-Related Disorders” 更正“围产期妇女接受个体认知行为疗法(CBT)治疗抑郁、焦虑和创伤相关障碍的治疗参与和结果相关因素的系统综述”。
IF 3.3 2区 医学 Q1 PSYCHIATRY Pub Date : 2026-02-03 DOI: 10.1155/da/9761031

N. A. Simon, J. Evans, D. Bispham, et al., “A Systematic Review of Factors Associated With Treatment Engagement and Outcome for Women in the Perinatal Period Receiving Individual Cognitive Behavioral Therapy (CBT) for Depression, Anxiety, and Trauma-Related Disorders,” Depression and Anxiety 2025 (2025): 3698331, https://doi.org/10.1155/da/3698331.

In the article titled, “A Systematic Review of Factors Associated With Treatment Engagement and Outcome for Women in the Perinatal Period Receiving Individual Cognitive Behavioral Therapy (CBT) for Depression, Anxiety, and Trauma-Related Disorders,” author Jonathan Jones was affiliated to Perinatal Community Mental Health Service, Cardiff and Vale UHB, Wales, Cardiff, UK, which is incorrect. The correct affiliation for this author is as follows:

University Library Service, Cardiff University, Cardiff, Wales.

The corrected list of affiliations is shown in the author information below:

Natalie A. Simon1, Jenna Evans2, Darcy Bispham2, Ffion Williams2, Jonathan Jones3, Neil P. Roberts4, and Cerith S. Waters1,2

1South Wales Clinical Psychology Training Program, School of Psychology, Cardiff University, Wales, Cardiff, UK

2Perinatal Community Mental Health Service, Cardiff and Vale UHB, Wales, Cardiff, UK

3University Library Service, Cardiff University, Cardiff, Wales

4Division of Psychological Medicine and Clinical Neuroscience, Cardiff University, Wales, Cardiff, UK

We apologize for this error.

[这更正了文章DOI: 10.1155/da/3698331.]。
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引用次数: 0
The Effect of Family Functioning on Depressive Symptoms in Adolescents: A Moderated Mediation Model 家庭功能对青少年抑郁症状的影响:一个有调节的中介模型
IF 3.3 2区 医学 Q1 PSYCHIATRY Pub Date : 2026-02-01 DOI: 10.1155/da/9965173
Zhang Jiayuan, Zhang Hui, Li Yang, Zhou Yuqiu

Background

Family dysfunction and insecure attachment are established risk factors for adolescent depressive symptoms, yet individual differences in sensory processing may influence vulnerability to these environmental stressors.

Objective

To explore the mediating role of insecure attachment and the moderating effect of sensory processing sensitivity (SPS) in the relationship between family functioning and adolescent depressive symptoms.

Methods

This study employed a cross-sectional design, with 503 adolescents recruited via convenience sampling in October 2023. Participants completed self-report questionnaires assessing family functioning, insecure attachment, SPS, and depressive symptoms. SPSS 26.0 was used to conduct moderated mediation analyses to examine the complex interactions among these variables.

Results

The results showed that family functioning was directly associated with adolescent depressive symptoms and also was indirectly associated with depressive symptoms through insecure attachment. Additionally, SPS was found to statistically moderate both the direct and indirect pathways. Specifically, the negative association between poor family functioning and depressive symptoms and the statistical mediating pathway through insecure attachment were more pronounced in adolescents with higher SPS.

Conclusion

Impaired family functioning and insecure attachment were associated with higher levels of depressive symptoms in adolescents. SPS appeared to strengthen these associations, highlighting the importance of considering individual differences in sensory sensitivity when addressing adolescent mental health. Tailoring interventions to strengthen family support and attachment security, especially for adolescents with heightened SPS, may help mitigate the risk of depressive symptoms. This study emphasizes the need for family-centered interventions to foster resilience against adolescent depressive symptoms.

背景:家庭功能障碍和不安全依恋是青少年抑郁症状的危险因素,但感觉加工的个体差异可能影响对这些环境压力源的易感性。目的:探讨不安全依恋在家庭功能与青少年抑郁症状关系中的中介作用及感觉加工敏感性(SPS)的调节作用。方法:本研究采用横断面设计,于2023年10月通过方便抽样方法招募503名青少年。参与者完成自我报告问卷,评估家庭功能、不安全依恋、SPS和抑郁症状。使用SPSS 26.0进行有调节的中介分析,以检验这些变量之间复杂的相互作用。结果:家庭功能与青少年抑郁症状直接相关,并通过不安全依恋与抑郁症状间接相关。此外,从统计上看,SPS对直接和间接途径都有调节作用。具体而言,家庭功能不良与抑郁症状之间的负相关以及不安全依恋的统计中介途径在SPS较高的青少年中更为明显。结论:家庭功能受损和不安全依恋与青少年抑郁症状水平升高相关。SPS似乎加强了这些联系,强调了在处理青少年心理健康时考虑感官敏感性个体差异的重要性。量身定制的干预措施,以加强家庭支持和依恋安全,特别是对于高度SPS的青少年,可能有助于减轻抑郁症状的风险。本研究强调需要以家庭为中心的干预措施,以培养对青少年抑郁症状的适应能力。
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引用次数: 0
Sustaining Recovery After Low-Intensity Treatment for Anxiety and Depression in NHS Talking Therapies: A Multiphase Participatory and Consensus-Building Study of Stakeholder Priorities and Recommendations 在NHS谈话疗法中,低强度治疗焦虑和抑郁后的持续恢复:利益相关者优先事项和建议的多阶段参与性和共识建立研究。
IF 3.3 2区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-28 DOI: 10.1155/da/9916526
Saher Nawaz, Penny Bee, Cintia Faija

Anxiety and depression affect over 500 million people globally. Despite the availability of effective low-cost treatments, like those provided by NHS talking therapies (TT), over half of patients relapse within a year, highlighting the need to co-develop solutions to maintain wellbeing and optimise healthcare. This study used a multiphase participatory design to synthesise evidence on relapse prevention and collaboratively develop evidence-informed strategies for sustained mental health following low-intensity treatment. The three-phase project began by synthesising evidence from diverse sources. Phase 2 involved two patient and two NHS professional/key stakeholder co-design workshops, using the RAND/UCLA appropriateness method. A sustained patient and public involvement (PPI) group reviewed and refined findings, co-designing content for phase 3, which involved a mixed-stakeholder online meeting to finalise key recommendations and priorities. Phase 1 identified 41 evidence-based solutions for rating during phase 2. Across the four phase 2 workshops (n = 18), 24 solutions were rated as appropriate and necessary and ranked for priorities. These were refined with the PPI group into 13 core recommendations. These recommendations were incorporated into a relapse prevention model during the final workshop, forming a foundation to enhance post-treatment support and inform clinical practice, service design, workforce training and policy. Preventing relapse and supporting wellbeing are essential for improving patient outcomes and reducing health inequalities. Identifying priorities across multiple levels lays the groundwork for a robust relapse prevention model that promotes sustained recovery. Future research should implement and evaluate the feasibility and impact of these recommendations in routine care.

焦虑和抑郁影响着全球超过5亿人。尽管有有效的低成本治疗方法,如NHS谈话疗法(TT),但超过一半的患者在一年内复发,这突出了共同开发解决方案以保持健康和优化医疗保健的必要性。本研究采用多阶段参与式设计来综合预防复发的证据,并协作制定低强度治疗后持续精神健康的循证策略。这个分三个阶段的项目首先综合了来自不同来源的证据。第二阶段涉及两名患者和两名NHS专业人员/关键利益相关者共同设计研讨会,使用RAND/UCLA适当性方法。一个持续的患者和公众参与(PPI)小组审查并完善了研究结果,共同设计了第三阶段的内容,其中包括一个混合利益相关者在线会议,以确定关键建议和优先事项。第一阶段在第二阶段确定了41个基于证据的评级解决方案。在四个第二阶段的研讨会(n = 18)中,24个解决方案被评为适当和必要的,并按优先级进行排序。这些与PPI组一起被细化为13项核心建议。在最后一次研讨会期间,这些建议被纳入预防复发模型,为加强治疗后支持和为临床实践、服务设计、劳动力培训和政策提供信息奠定了基础。预防复发和支持健康对于改善患者预后和减少健康不平等至关重要。确定跨多个层面的优先事项,为建立促进持续康复的强有力的复发预防模式奠定了基础。未来的研究应实施和评估这些建议在常规护理中的可行性和影响。
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引用次数: 0
Major Depressive Disorder With Versus Without Psychosocial Triggers: A Secondary Analysis of a Prospective Cohort Study 有与无社会心理诱因的重度抑郁症:一项前瞻性队列研究的二次分析。
IF 3.3 2区 医学 Q1 PSYCHIATRY Pub Date : 2026-01-21 DOI: 10.1155/da/3389394
Chunfeng Xiao, Shuilin Wu, Lili Shi, Tao Li, Yanping Duan, Xin Yu, Gang Wang, Gang Zhu, Kerang Zhang, Jinya Cao, Jing Wei

Background

Few studies have examined differences in symptom presentation and antidepressant response between patients with major depressive disorder (MDD) with and without psychosocial triggers.

Methods

This was a secondary analysis of a multicenter, multistage prospective cohort study conducted at nine top tertiary hospitals across six provinces/municipalities in China. The cohort included patients with first-episode MDD, with or without psychosocial triggers, who received one of six selective serotonin reuptake inhibitors (SSRIs).

Results

Of 359 enrolled patients with first-episode MDD, 303 (mean [SD] age, 39.6 [10.1] years; 201 [66.8%] women) were included in the final analysis. There were no significant differences in network structure (M = 0.40; p = 0.97) or global strength (global strength difference [GS] = 0.483; p = 0.91) between the two groups. However, network analyses identified distinct core and influential bridge symptoms: psychic anxiety (node strength [Str] = 2.161; bridge strength [BStr] = 1.908) and somatic anxiety (Str = 2.142; BStr = 1.664) in the MDD with psychosocial triggers group, while depressed mood (Str = 3.114; BStr = 2.793) and genital symptoms (Str = 3.085; BStr = 3.085) in the group without psychosocial triggers. There were no significant differences in response rates at all visits. Median time to first response was 4.0 weeks in both groups (log-rank p = 0.23).

Conclusions

While patients with MDD with and without psychosocial triggers shared broadly similar clinical profiles and SSRI responses, differences in symptom network architecture may have implications for individualized symptom monitoring and treatment strategies.

背景:很少有研究调查有和没有社会心理诱因的重度抑郁症(MDD)患者在症状表现和抗抑郁药反应方面的差异。方法:这是一项在中国6个省/市的9家顶级三级医院进行的多中心、多阶段前瞻性队列研究的二次分析。该队列包括首发MDD患者,有或没有社会心理诱因,接受六种选择性血清素再摄取抑制剂(SSRIs)中的一种。结果:在359例首发MDD患者中,最终分析纳入303例(平均[SD]年龄39.6[10.1]岁,201例(66.8%)为女性)。两组在网络结构(M = 0.40; p = 0.97)或整体强度(整体强度差[GS] = 0.483; p = 0.91)方面无显著差异。然而,网络分析发现了不同的核心和有影响的桥梁症状:有社会心理触发的MDD组的精神焦虑(节点强度[Str] = 2.161;桥梁强度[BStr] = 1.908)和躯体焦虑(Str = 2.142; BStr = 1.664),而无社会心理触发的MDD组的抑郁情绪(Str = 3.114; BStr = 2.793)和生殖器症状(Str = 3.085; BStr = 3.085)。在所有访问中,应答率没有显著差异。两组至首次反应的中位时间均为4.0周(log-rank p = 0.23)。结论:虽然有和没有社会心理诱因的重度抑郁症患者的临床特征和SSRI反应大致相似,但症状网络结构的差异可能对个体化症状监测和治疗策略有影响。
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Depression and Anxiety
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