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Peripheral Blood Mononuclear Cell Biomarkers for Major Depressive Disorder: A Transcriptomic Approach 重度抑郁症的外周血单核细胞生物标志物:转录组学方法
IF 4.7 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-03 DOI: 10.1155/2024/1089236
Lu Sun, CaiLi Ren, HaoBo Leng, Xin Wang, DaoRan Wang, TianQi Wang, ZhiQiang Wang, GuoFu Zhang, Haitao Yu

Background: Major depressive disorder (MDD) is a complex condition characterized by persistent depressed mood, loss of interest or pleasure, loss of energy or fatigue, and, in severe case, recurrent thoughts of death. Despite its prevalence, reliable diagnostic biomarkers for MDD remain elusive. Identifying peripheral biomarkers for MDD is crucial for early diagnosis, timely intervention, and ultimately reducing the risk of suicide. Metabolic changes in peripheral blood mononuclear cells (PBMCs) have been observed in animal models of depression, suggesting that PBMC could serve as a valuable matrix for exploring potential peripheral biomarkers in MDD.

Methods: We performed a transcriptomic analysis of PBMCs from patients with MDD and age- and sex-matched healthy controls (n = 20 per group).

Results: Our analysis identified 270 differentially expressed genes in PBMCs from MDD patients compared to controls, which correlated with the Hamilton Depression Rating Scale scores. These genes are involved in several KEGG pathways, including the herpes simplex virus 1 infection pathway, NOD-like receptor signaling pathway, antigen processing and presentation, and glycerophospholipid metabolism—all of which are linked to various aspects of the immune response. Further machine learning analysis and quantitative real-time PCR (qPCR) validation identified three key genes—TRPV2, ZNF713, and CTSL—that effectively distinguish MDD patients from healthy controls.

Conclusions: The immune dysregulation observed in PBMCs is closely related to the pathogenesis of MDD. The candidate biomarkers TRPV2, ZNF713, and CTSL, identified and validated through machine learning and qPCR, hold promise for the objective diagnosis of MDD.

Trial Registration: Clinical Trial Registry identifier: ChiCTR2300076589

背景:重度抑郁障碍(MDD)是一种复杂的疾病,其特征是持续的情绪低落、失去兴趣或乐趣、丧失精力或疲劳,严重时还会反复出现死亡的念头。尽管MDD普遍存在,但可靠的MDD诊断生物标志物仍然难以捉摸。确定 MDD 的外周生物标志物对于早期诊断、及时干预以及最终降低自杀风险至关重要。在抑郁症动物模型中已观察到外周血单核细胞(PBMC)的代谢变化,这表明外周血单核细胞可作为探索 MDD 潜在外周生物标志物的重要基质。 研究方法我们对 MDD 患者和年龄、性别匹配的健康对照组(每组 20 人)的 PBMC 进行了转录组学分析。 结果与对照组相比,我们的分析在 MDD 患者的 PBMCs 中发现了 270 个差异表达基因,这些基因与汉密尔顿抑郁量表评分相关。这些基因参与了多个 KEGG 通路,包括单纯疱疹病毒 1 感染通路、NOD 样受体信号通路、抗原处理和呈递以及甘油磷脂代谢--所有这些都与免疫反应的各个方面有关。进一步的机器学习分析和定量实时 PCR(qPCR)验证确定了三个关键基因--TRPV2、ZNF713 和 CTSL,它们能有效区分 MDD 患者和健康对照组。 结论在 PBMCs 中观察到的免疫失调与 MDD 的发病机制密切相关。通过机器学习和 qPCR 鉴定和验证的候选生物标志物 TRPV2、ZNF713 和 CTSL 有望用于 MDD 的客观诊断。 试验注册:临床试验注册标识符:ChiCTR2300076589ChiCTR2300076589
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引用次数: 0
Prevalence and Risk Factors of Postpartum Depression Among Women in Low-Income Developing Rural Areas: A Cross-Sectional Study in China 低收入发展中农村地区妇女产后抑郁症的患病率和风险因素:中国的一项横断面研究
IF 4.7 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-10-01 DOI: 10.1155/2024/8841423
Mei Sun, Fanfan Cao, Jiayuan Peng, Jingfei Tang, Yuqing He, Yi Zeng, Xiangmin Tan, Qian Zhao

Background: Postpartum depression (PPD) significantly affects the welfare of mothers, infants, families, and communities. Mothers in rural areas often face low incomes, poor social security, low education levels, and inadequate medical services. These specific cultural, social, and economic aspects have led to a worsening of PPD in rural areas. However, the current situation of PPD among women in rural areas of China is still insufficiently explored.

Aim: This study aims to explore the prevalence and risk factors of PPD among women in low-income developing rural areas of China.

Methods: A cross-sectional design was used in this study. Edinburgh Postnatal Depression Scale (EPDS) was applied to evaluate PPD symptoms. General demographic questionnaire, obstetrics-/pediatrics-related questionnaire, and psychosocial-related questionnaire were adopted. Abuse Assessment Screen (AAS) was utilized to assess experienced intimate partner violence during pregnancy and postpartum. Social Support Rating Scale (SSRS) was utilized to measure their levels of social support.

Results: Of the 467 participants, the overall prevalence of PPD among women in rural areas of China was 16.5%, and the average EPDS score was 8.35 (SD = 4.50). PPD occurred most frequently at 7–9 months postpartum (33.8%). Six factors associated with PPD were whether the sex of the baby was in line with the family’s expectations, monthly income of partners, social support, IPV during pregnancy and childbirth, and negative life events in the last 1 year, as well as physical and mental exhaustion from caring for a baby.

Conclusions: This study sheds light on the prevalence and various risk factors associated with PPD among women residing in low-income developing rural areas of China. The findings highlighted the need for targeted interventions and support systems designed to address the specific socioeconomic and cultural difficulties encountered by rural mothers.

背景:产后抑郁症(PPD)严重影响母亲、婴儿、家庭和社区的福利。农村地区的母亲往往面临收入低、社会保障差、教育水平低和医疗服务不足等问题。这些特殊的文化、社会和经济因素导致了农村地区 PPD 的恶化。然而,对中国农村地区妇女 PPD 现状的了解还不够。 目的:本研究旨在探讨中国低收入发展中农村地区妇女 PPD 的患病率和风险因素。 研究方法本研究采用横断面设计。采用爱丁堡产后抑郁量表(EPDS)评估产后抑郁症状。采用一般人口学问卷、产科/儿科相关问卷和社会心理相关问卷。虐待评估筛查(AAS)用于评估孕期和产后遭受亲密伴侣暴力的情况。社会支持评定量表(SSRS)用于测量她们的社会支持水平。 结果显示在 467 名参与者中,中国农村地区妇女的 PPD 患病率为 16.5%,EPDS 平均得分为 8.35(SD = 4.50)。PPD最常发生在产后7-9个月(33.8%)。与 PPD 相关的六个因素是:婴儿的性别是否符合家庭的期望、伴侣的月收入、社会支持、怀孕和分娩期间的 IPV、过去 1 年中的负面生活事件以及照顾婴儿造成的身心疲惫。 结论本研究揭示了居住在中国低收入发展中农村地区的妇女中PPD的患病率及其相关的各种风险因素。研究结果突出表明,有必要针对农村母亲在社会经济和文化方面遇到的特殊困难,设计有针对性的干预措施和支持系统。
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引用次数: 0
High Blood Pressure and Depression Among the Working Population of Ghana: A Generalized Linear Model of the Risk Factors 加纳工作人口中的高血压和抑郁症:风险因素的广义线性模型
IF 4.7 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-09-30 DOI: 10.1155/2024/5261760
Michael Arthur Ofori, David Kwamena Mensah, Ildephonse Nizeyimana, Niharika Jha, Zebunnesa Zeba, Shongkour Roy

Background. The global presence of high blood pressure and depression poses a significant public health threat, particularly in emerging nations. High blood pressure and depression are inevitable among the working population of Ghana, and it is crucial to recognize the potential influence of these conditions on the working-age population.

Materials and Methods. The study analyzed the risk factors associated with high blood pressure and depression among the working population of Ghana. The data in this study were drawn from Wave 1 data of the Study on Global Ageing and Adult Health (SAGE) survey, which was conducted by World Health Organization (WHO) in Ghana from January 2007 to December 2008. A longitudinal survey under the banner of SAGE was conducted. The study used 2681 participants aged 18–60 years. We modeled high blood pressure using logistic regression and depression with the proportional odds model of ordinal logistic regression.

Results. The study revealed that the prevalence of depression among the working-age population was 42.5%, whereas that of high blood pressure was 48.7%. The result also showed that males have a lower risk of developing high blood pressure and depression (OR = 0.851 and OR = 0.658, respectively) compared with females. Also, older adults (40–60 years) have a higher risk of developing high blood pressure and depression (OR = 1.992 and OR = 2.334, respectively) compared with younger adults. Other risk factors associated with high blood pressure include diabetes (2.107), depression, and weight. Last, alcohol intake (1.502), tobacco intake (1.279), and high blood pressure were found to be other risk factors associated with depression.

Conclusion. The prevalence of depression and high blood pressure is high among the working population of Ghana. There is therefore the need to incorporate health awareness programs on these topics.

背景。全球范围内存在的高血压和抑郁症对公共健康构成了严重威胁,尤其是在新兴国家。高血压和抑郁症在加纳劳动人口中不可避免,因此认识到这些疾病对劳动适龄人口的潜在影响至关重要。 材料与方法。本研究分析了加纳劳动人口中与高血压和抑郁症相关的风险因素。本研究的数据来自世界卫生组织(WHO)于 2007 年 1 月至 2008 年 12 月在加纳进行的全球老龄化与成人健康研究(SAGE)调查的第一波数据。该调查是在 SAGE 的旗帜下进行的一项纵向调查。这项研究使用了 2681 名年龄在 18-60 岁之间的参与者。我们使用逻辑回归对高血压进行建模,并使用顺序逻辑回归的比例几率模型对抑郁症进行建模。 结果显示研究显示,抑郁症在工作年龄人口中的患病率为 42.5%,而高血压的患病率为 48.7%。结果还显示,与女性相比,男性患高血压和抑郁症的风险较低(OR = 0.851 和 OR = 0.658)。此外,与年轻人相比,老年人(40-60 岁)患高血压和抑郁症的风险更高(OR = 1.992 和 OR = 2.334)。与高血压相关的其他风险因素包括糖尿病(2.107)、抑郁症和体重。最后,酒精摄入量(1.502)、烟草摄入量(1.279)和高血压也是与抑郁症相关的风险因素。 结论在加纳的工作人口中,抑郁症和高血压的发病率很高。因此,有必要就这些主题开展健康宣传计划。
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引用次数: 0
Depressive Symptoms and Metabolic Dysregulation Control: A Closer Look at Control Challenges in T2DM Patients 抑郁症状与代谢失调控制:近距离观察 T2DM 患者的控制挑战
IF 4.7 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-09-27 DOI: 10.1155/2024/7115559
Yang Yang, Zhenhua Xing

Background: Patients with type 2 diabetes mellitus (T2DM) face an increased risk of developing depression and metabolic dysregulation, which can lead to a higher risk of cardiovascular disease (CVD). However, the relationship between the severity of depression and metabolic dysregulation in patients with T2DM remains unclear. This study aimed to investigate this association using data from the ACCORD-health-related quality of life study.

Methods and Results: Patient Health Questionnaire-9 (PHQ-9) scores and medication regimens were assessed at baseline, 1, 3, and 4 years, and HbA1c, blood pressure, and lipid levels were monitored every 4 months over a 4-year period. The severity of depressive symptoms was categorized as none (0–4 points), mild (5–9 points), or moderate–severe (10–24 points) based on PHQ-9 scores. Among the participants, 62% developed depressive symptoms at some point during the 4-year follow-up period, with 21% experiencing persistent depressive symptoms. Participants with moderate-to-severe depression exhibited 0.18% (0.12, 0.24) higher levels of HbA1c, 1.11 mmHg (95% CI, 0.04, 2.15) of SBP, 0.90 mmHg (95% CI, 0.22,1.58) of DBP, and 2.12(95% CI, −0.03, 4.27) mg/dL of LDL, and 0.97 (95% CI, 0.38, 1.56) mg/dL lower levels of HDL compared to their counterparts without depressive symptoms. Moreover, as the severity of depressive symptoms increased, variability in HbA1c and blood pressure levels also increased. Furthermore, patients with more severe depressive symptoms demonstrated suboptimal adherence to medication regimens.

Conclusion: Our study found a significant association between depressive symptoms severity and metabolic control in T2DM patients. Greater depressive severity correlated with poorer glycemic, blood pressure, and lipid control, alongside increased variability in these parameters. Additionally, patients with severe depressive symptoms showed suboptimal medication adherence. Addressing mental health in T2DM management is crucial to improve metabolic control and reduce CVD risks.

Trial Registration: ClinicalTrials.gov identifier: NCT00000620

背景:2 型糖尿病(T2DM)患者患抑郁症和代谢失调的风险增加,这可能导致心血管疾病(CVD)风险升高。然而,T2DM 患者抑郁的严重程度与代谢失调之间的关系仍不清楚。本研究旨在利用 ACCORD--健康相关生活质量研究的数据调查这种关系。 方法和结果:在基线、1 年、3 年和 4 年时评估了患者健康问卷-9(PHQ-9)得分和用药方案,并在 4 年期间每 4 个月监测一次 HbA1c、血压和血脂水平。根据 PHQ-9 评分,抑郁症状的严重程度分为无(0-4 分)、轻度(5-9 分)和中度-重度(10-24 分)。在为期 4 年的随访期间,62% 的参与者在某个阶段出现了抑郁症状,其中 21% 的人持续出现抑郁症状。中度至重度抑郁症患者的 HbA1c 水平高出 0.18% (0.12, 0.24),SBP 高出 1.11 mmHg (95% CI, 0.04, 2.15),DBP 高出 0.90 mmHg (95% CI, 0.22, 1.58),DBP 高出 2.与没有抑郁症状的同龄人相比,低密度脂蛋白水平低 2.12(95% CI,-0.03,4.27)毫克/分升,高密度脂蛋白水平低 0.97(95% CI,0.38,1.56)毫克/分升。此外,随着抑郁症状严重程度的增加,HbA1c 和血压水平的变化也会增加。此外,抑郁症状更严重的患者对药物治疗的依从性也不理想。 结论我们的研究发现,T2DM 患者的抑郁症状严重程度与代谢控制之间存在明显关联。抑郁症严重程度越高,血糖、血压和血脂控制越差,同时这些参数的变异性也越大。此外,有严重抑郁症状的患者对药物治疗的依从性较差。在 T2DM 管理中关注心理健康对于改善代谢控制和降低心血管疾病风险至关重要。 试验注册:临床试验注册:ClinicalTrials.gov identifier:NCT00000620
{"title":"Depressive Symptoms and Metabolic Dysregulation Control: A Closer Look at Control Challenges in T2DM Patients","authors":"Yang Yang,&nbsp;Zhenhua Xing","doi":"10.1155/2024/7115559","DOIUrl":"https://doi.org/10.1155/2024/7115559","url":null,"abstract":"<div>\u0000 <p><b>Background:</b> Patients with type 2 diabetes mellitus (T2DM) face an increased risk of developing depression and metabolic dysregulation, which can lead to a higher risk of cardiovascular disease (CVD). However, the relationship between the severity of depression and metabolic dysregulation in patients with T2DM remains unclear. This study aimed to investigate this association using data from the ACCORD-health-related quality of life study.</p>\u0000 <p><b>Methods and Results:</b> Patient Health Questionnaire-9 (PHQ-9) scores and medication regimens were assessed at baseline, 1, 3, and 4 years, and HbA1c, blood pressure, and lipid levels were monitored every 4 months over a 4-year period. The severity of depressive symptoms was categorized as none (0–4 points), mild (5–9 points), or moderate–severe (10–24 points) based on PHQ-9 scores. Among the participants, 62% developed depressive symptoms at some point during the 4-year follow-up period, with 21% experiencing persistent depressive symptoms. Participants with moderate-to-severe depression exhibited 0.18% (0.12, 0.24) higher levels of HbA1c, 1.11 mmHg (95% CI, 0.04, 2.15) of SBP, 0.90 mmHg (95% CI, 0.22,1.58) of DBP, and 2.12(95% CI, −0.03, 4.27) mg/dL of LDL, and 0.97 (95% CI, 0.38, 1.56) mg/dL lower levels of HDL compared to their counterparts without depressive symptoms. Moreover, as the severity of depressive symptoms increased, variability in HbA1c and blood pressure levels also increased. Furthermore, patients with more severe depressive symptoms demonstrated suboptimal adherence to medication regimens.</p>\u0000 <p><b>Conclusion:</b> Our study found a significant association between depressive symptoms severity and metabolic control in T2DM patients. Greater depressive severity correlated with poorer glycemic, blood pressure, and lipid control, alongside increased variability in these parameters. Additionally, patients with severe depressive symptoms showed suboptimal medication adherence. Addressing mental health in T2DM management is crucial to improve metabolic control and reduce CVD risks.</p>\u0000 <p><b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT00000620</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2024 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/7115559","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142328493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations Between Brain Structural Connectivity and 1-Year Demoralization in Breast Cancer: A Longitudinal Diffusion Tensor Imaging Study 乳腺癌患者大脑结构连通性与 1 年去势之间的关系:纵向弥散张量成像研究
IF 4.7 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-09-26 DOI: 10.1155/2024/5595912
Mu Zi Liang, Peng Chen, Ying Tang, Yu Yan Liang, Shu Han Li, Guang Yun Hu, Zhe Sun, Yuan Liang Yu, Alex Molassiotis, M. Tish Knobf, Zeng Jie Ye

Purposes: This study aims to explore the association between brain structural connectivity and 1-year demoralization in patients with newly diagnosed breast cancer.

Methods: Patients were enrolled from a multicenter longitudinal program named as Be Resilient to Breast Cancer (BRBC) between 2017 and 2019. Brain structural connectivity was assessed with diffusion tensor imaging (DTI) at baseline and the demoralization scale II collected self-report data at baseline and 1 year later. A data-driven correlational tractography was performed to recognize significant neural pathways associated with the group membership (increased vs. nonincreased demoralization). The incremental prediction values of Quantitative Anisotropy (QA) extracted from the significant white matter tracts against the group membership were evaluated.

Results: 21.2% (N = 31) reported increased 1-year demoralization. Inferior fronto-occipital fasciculus (IFOF) was associated with 1-year demoralization in breast cancer. The incremental prediction values of QAs in net reclassification improvement (NRI) and integrated discrimination improvement (IDI) ranged from 8.11% to 46.89% and 9.12% to 23.95%, respectively, over the conventional tumor-nodal metatasis (TNM) staging model.

Conclusion: Anisotropy in IFOF is a potential prediction neuromarker to 1-year demoralization in patients with newly diagnosed breast cancer.

Trial Registration: ClinicalTrials.gov identifier: NCT03026374

研究目的本研究旨在探讨新诊断乳腺癌患者的大脑结构连接性与 1 年去势之间的关联。 研究方法2017年至2019年期间,多中心纵向项目 "乳腺癌康复计划(BRBC)"招募了部分患者。基线时使用弥散张量成像(DTI)评估大脑结构连通性,并在基线和1年后收集士气量表II的自我报告数据。进行了数据驱动的相关牵引成像,以识别与群体成员身份(士气低落增加与未增加)相关的重要神经通路。评估了从重要白质束中提取的定量各向异性(QA)增量预测值与群体成员资格的关系。 结果:21.2%(N = 31)的患者在 1 年后去势加剧。前枕下束(IFOF)与乳腺癌患者的 1 年去势相关。与传统的肿瘤-结节转移(TNM)分期模型相比,QAs在净重分类改进(NRI)和综合鉴别改进(IDI)方面的预测增量值分别为8.11%至46.89%和9.12%至23.95%。 结论IFOF的各向异性是新诊断乳腺癌患者1年去势的潜在预测神经标志物。 试验注册:ClinicalTrials.gov 标识符:NCT03026374
{"title":"Associations Between Brain Structural Connectivity and 1-Year Demoralization in Breast Cancer: A Longitudinal Diffusion Tensor Imaging Study","authors":"Mu Zi Liang,&nbsp;Peng Chen,&nbsp;Ying Tang,&nbsp;Yu Yan Liang,&nbsp;Shu Han Li,&nbsp;Guang Yun Hu,&nbsp;Zhe Sun,&nbsp;Yuan Liang Yu,&nbsp;Alex Molassiotis,&nbsp;M. Tish Knobf,&nbsp;Zeng Jie Ye","doi":"10.1155/2024/5595912","DOIUrl":"https://doi.org/10.1155/2024/5595912","url":null,"abstract":"<div>\u0000 <p><b>Purposes:</b> This study aims to explore the association between brain structural connectivity and 1-year demoralization in patients with newly diagnosed breast cancer.</p>\u0000 <p><b>Methods:</b> Patients were enrolled from a multicenter longitudinal program named as <i>Be Resilient to Breast Cancer</i> (BRBC) between 2017 and 2019. Brain structural connectivity was assessed with diffusion tensor imaging (DTI) at baseline and the demoralization scale II collected self-report data at baseline and 1 year later. A data-driven correlational tractography was performed to recognize significant neural pathways associated with the group membership (increased vs. nonincreased demoralization). The incremental prediction values of Quantitative Anisotropy (QA) extracted from the significant white matter tracts against the group membership were evaluated.</p>\u0000 <p><b>Results:</b> 21.2% (<i>N</i> = 31) reported increased 1-year demoralization. Inferior fronto-occipital fasciculus (IFOF) was associated with 1-year demoralization in breast cancer. The incremental prediction values of QAs in net reclassification improvement (NRI) and integrated discrimination improvement (IDI) ranged from 8.11% to 46.89% and 9.12% to 23.95%, respectively, over the conventional tumor-nodal metatasis (TNM) staging model.</p>\u0000 <p><b>Conclusion:</b> Anisotropy in IFOF is a potential prediction neuromarker to 1-year demoralization in patients with newly diagnosed breast cancer.</p>\u0000 <p><b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT03026374</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2024 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/5595912","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142324604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Declining Time-Trend in Loneliness Levels Among Migrant Children in Urban China, 2006−2019: A Cross-Temporal Meta-Analysis of 40 Studies Published From 2006 to 2022 2006-2019年中国城市流动儿童孤独感水平下降的时间趋势:对2006-2022年发表的40项研究的跨时空Meta分析
IF 4.7 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-09-25 DOI: 10.1155/2024/3094214
Lin-Feng Ge, Rui-Yao Wu, Bao-Liang Zhong

Loneliness has long been a significant psychosocial problem for migrant children in urban China. In recent years, social changes and enhancements in social welfare equity have lessened the disadvantages faced by these migrant children. The current study investigated the time-trend of loneliness levels among migrant children from 2006 to 2019. A literature search was performed within major Chinese- and English-language databases, and studies that reported the means and standard deviations of Children’s Loneliness Scale (CLS) scores among Chinese migrant children were included in this cross-temporal meta-analysis. Weighted linear regression was conducted to examine the trend of mean CLS scores over the survey year, and Cohen’s d value was calculated to assess the magnitude of change. In total, 40 cross-sectional studies conducted between 2006 and 2019 (published by 2022), consisting of 47 cohorts of migrant children and a total sample size of 17,090, were included. Overall, there was a significant downward trend between the survey year and mean CLS score (unstandardized coefficient [β] = −0.342, P  < 0.001), and Cohen’s d value of this decline from 2006 to 2019 was 0.411. Similar declining time-trends were also observed among subgroups when broken down by sex, school type, and geographic regions (β = −0.182 to −0.589, P  < 0.001, d = 0.222–0.719). The loneliness levels of migrant children in urban China decreased from 2006 to 2019. Nevertheless, sustained measures and inclusive policies are still needed to mitigate the loneliness levels of Chinese migrant children.

长期以来,孤独一直是中国城市流动儿童的一个重要社会心理问题。近年来,社会变迁和社会福利公平的提高缓解了这些流动儿童所面临的不利处境。本研究调查了 2006 年至 2019 年流动儿童孤独感水平的时间趋势。研究人员在主要的中英文数据库中进行了文献检索,并将报告了中国流动儿童孤独感量表(CLS)得分均值和标准差的研究纳入此次跨时空荟萃分析。我们采用加权线性回归的方法来研究儿童孤独感量表(CLS)平均分在调查年度内的变化趋势,并通过计算Cohen's d值来评估变化的幅度。共纳入了 40 项在 2006 年至 2019 年(2022 年之前发表)期间进行的横断面研究,包括 47 个流动儿童队列,样本量共计 17,090 个。总体而言,调查年份与CLS平均得分之间存在显著的下降趋势(非标准化系数[β] = -0.342,P <0.001),从2006年到2019年,这一下降的Cohen's d值为0.411。按性别、学校类型和地理区域细分时,在亚组中也观察到类似的下降时间趋势(β = -0.182 to -0.589,P < 0.001,d = 0.222-0.719)。从2006年到2019年,中国城市流动儿童的孤独程度有所下降。然而,要降低中国流动儿童的孤独感水平,仍需要持续的措施和包容性政策。
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引用次数: 0
Internal Consistency and Validity of a Short Spanish Version (10-Items) of the Center for Epidemiological Studies Depression Scale for Children and Adolescents (CES-DC) 流行病学研究中心儿童和青少年抑郁量表(CES-DC)西班牙语简版(10 个项目)的内部一致性和有效性
IF 4.7 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-09-25 DOI: 10.1155/2024/5409747
María Eugenia Visier-Alfonso, Estela Jiménez-López, Eva Rodríguez-Gutiérrez, Arthur Eumann Mesas, Sergio Núñez de Arenas-Arroyo, Valentina Díaz-Goñi, Celia Álvarez-Bueno, Vicente Martínez-Vizcaíno

Purpose: The 20-item Center for Epidemiological Studies Depression Scale for Children and Adolescents (CES-DC) is an instrument for screening of depression with good psychometric properties. This study aimed to examine the construct validity in terms of structural and convergent validity, the internal consistency, and the concurrent validity of a shorter 10-item version of this scale.

Methods: This was a cross-sectional validation study including 671 schoolchildren aged 9–11, from Cuenca, Spain. Depression was assessed using the 20-item CES-DC scale. We selected the 10 items with the highest factorial loading for a shorter version. Sociodemographic, anthropometric, fitness, and quality of life variables were considered to analyse convergent and discriminant validity.

Results: For the structural validity, confirmatory factor analyses revealed a three-factor latent structure for the 20-item CES-DC and a single factor in the 10-item version. Internal consistency measured by Cronbach’s α and ω statistic were 0.85 for 20-item CES-DC and 0.84 for 10-item CES-DC. Intraclass correlation coefficient between the two scales was 0.94. Convergent validity was tested through the correlation coefficients and regression models between both either CES-DC versions with body mass index, waist circumference, fitness, and quality of life measures, which were similar. For the concurrent validity, concordance analysis and the ROC curve showed an equivalent cut-off point for the 10-item CES-DC. The 20-item CES-DC classified a total of 33.1% of the sample as at risk of depression, while the 10-item CES-DC classified 30.4%.

Conclusion: This study indicates that both the 20-item and 10-item versions of the CES-DC have good internal consistency and structural validity in schoolchildren. Therefore, this short version can be used as a reliable and valid instrument for screening depression that is less time consuming and easy to use in clinical and scholarly contexts, potentially improving early detection and intervention for depression.

Trial Registration: ClinicalTrials.gov identifier: NCT03236337.

目的:由 20 个项目组成的儿童和青少年流行病学研究中心抑郁量表(CES-DC)是一种具有良好心理测量学特性的抑郁筛查工具。本研究旨在从结构效度和收敛效度、内部一致性和并发效度等方面对该量表的 10 个项目的简短版本进行检验。 研究方法这是一项横断面验证研究,包括来自西班牙昆卡的 671 名 9-11 岁学龄儿童。抑郁采用 20 个项目的 CES-DC 量表进行评估。我们选取了因子载荷最高的 10 个项目制作了一个简短版本。我们还考虑了社会人口学、人体测量、体能和生活质量等变量,以分析其收敛性和鉴别性。 结果如下在结构效度方面,确认性因子分析显示,20 个项目的 CES-DC 有一个三因子潜结构,而 10 个项目的版本只有一个因子。用 Cronbach's α 和 ω 统计量测量内部一致性,20 项 CES-DC 为 0.85,10 项 CES-DC 为 0.84。两个量表之间的类内相关系数为 0.94。通过两个版本的 CES-DC 与体重指数、腰围、体能和生活质量测量之间的相关系数和回归模型,对收敛效度进行了检验,结果相似。在并发效度方面,一致性分析和 ROC 曲线显示,10 项 CES-DC 的临界点相同。20项CES-DC将33.1%的样本归类为有抑郁风险,而10项CES-DC则将30.4%的样本归类为有抑郁风险。 结论本研究表明,CES-DC 的 20 项和 10 项版本在学龄儿童中均具有良好的内部一致性和结构效度。因此,该简短版本可作为一种可靠有效的抑郁症筛查工具,在临床和学术背景下使用,耗时少,操作简便,有望提高抑郁症的早期发现和干预水平。 试验注册:ClinicalTrials.gov 标识符:NCT03236337:NCT03236337。
{"title":"Internal Consistency and Validity of a Short Spanish Version (10-Items) of the Center for Epidemiological Studies Depression Scale for Children and Adolescents (CES-DC)","authors":"María Eugenia Visier-Alfonso,&nbsp;Estela Jiménez-López,&nbsp;Eva Rodríguez-Gutiérrez,&nbsp;Arthur Eumann Mesas,&nbsp;Sergio Núñez de Arenas-Arroyo,&nbsp;Valentina Díaz-Goñi,&nbsp;Celia Álvarez-Bueno,&nbsp;Vicente Martínez-Vizcaíno","doi":"10.1155/2024/5409747","DOIUrl":"https://doi.org/10.1155/2024/5409747","url":null,"abstract":"<div>\u0000 <p><b>Purpose:</b> The 20-item Center for Epidemiological Studies Depression Scale for Children and Adolescents (CES-DC) is an instrument for screening of depression with good psychometric properties. This study aimed to examine the construct validity in terms of structural and convergent validity, the internal consistency, and the concurrent validity of a shorter 10-item version of this scale.</p>\u0000 <p><b>Methods:</b> This was a cross-sectional validation study including 671 schoolchildren aged 9–11, from Cuenca, Spain. Depression was assessed using the 20-item CES-DC scale. We selected the 10 items with the highest factorial loading for a shorter version. Sociodemographic, anthropometric, fitness, and quality of life variables were considered to analyse convergent and discriminant validity.</p>\u0000 <p><b>Results:</b> For the structural validity, confirmatory factor analyses revealed a three-factor latent structure for the 20-item CES-DC and a single factor in the 10-item version. Internal consistency measured by Cronbach’s <i>α</i> and <i>ω</i> statistic were 0.85 for 20-item CES-DC and 0.84 for 10-item CES-DC. Intraclass correlation coefficient between the two scales was 0.94. Convergent validity was tested through the correlation coefficients and regression models between both either CES-DC versions with body mass index, waist circumference, fitness, and quality of life measures, which were similar. For the concurrent validity, concordance analysis and the ROC curve showed an equivalent cut-off point for the 10-item CES-DC. The 20-item CES-DC classified a total of 33.1% of the sample as at risk of depression, while the 10-item CES-DC classified 30.4%.</p>\u0000 <p><b>Conclusion:</b> This study indicates that both the 20-item and 10-item versions of the CES-DC have good internal consistency and structural validity in schoolchildren. Therefore, this short version can be used as a reliable and valid instrument for screening depression that is less time consuming and easy to use in clinical and scholarly contexts, potentially improving early detection and intervention for depression.</p>\u0000 <p><b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT03236337.</p>\u0000 </div>","PeriodicalId":55179,"journal":{"name":"Depression and Anxiety","volume":"2024 1","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/2024/5409747","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142316851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deficits in Emotional Perception–Related Motor Cortical Excitability in Individuals With Trait Anxiety: A Transcranial Magnetic Stimulation Study 特质焦虑症患者情绪感知相关运动皮层兴奋性的缺陷:经颅磁刺激研究
IF 4.7 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-09-24 DOI: 10.1155/2024/5532347
Hui Liu, Linqi Wang, Xiaoying Tan, Jian Zhang, Xue Xia

Abnormal emotional perception may contribute to emotional dysfunction in individuals with anxiety. This study explored the progression of impaired emotional perception with the deepening of anxiety in individuals with nonclinical trait anxiety, by measuring the motor cortical excitability associated with emotional perception. In total, 87 participants were assigned to a high trait anxiety (n = 27), moderate trait anxiety (n = 30), or low trait anxiety (n = 30) group. Transcranial magnetic stimulation was applied to the right primary motor cortex at 150 ms or 300 ms after the onset of positive, negative, or neutral images, while participants performed an emotion recognition task, and motor-evoked potentials (MEPs) were collected. For participants with low trait anxiety, MEP amplitudes were significantly higher for both negative and positive stimuli than for neutral stimuli. Participants with moderate trait anxiety showed significantly higher MEP amplitudes only for negative stimuli. Participants with high trait anxiety showed no significant difference in MEP amplitudes for positive, negative, and neutral stimuli. Trait anxiety score was negatively correlated with MEP amplitude: For higher trait anxiety scores, MEP amplitudes were correlated with lower emotional perception of positive and negative stimuli. Findings suggest that anxiety impairs emotional perception–related motor cortical excitability, starting with decreased motor cortical excitability responses to positive information and progressing to negative information as anxiety levels increase.

情绪感知异常可能会导致焦虑症患者出现情绪功能障碍。本研究通过测量与情绪感知相关的运动皮层兴奋性,探讨了非临床特质焦虑患者的情绪感知能力会随着焦虑的加深而受损。共有 87 名参与者被分配到高特质焦虑组(27 人)、中度特质焦虑组(30 人)或低特质焦虑组(30 人)。在正面、负面或中性图像出现后的 150 毫秒或 300 毫秒时,对参与者的右侧初级运动皮层进行经颅磁刺激,同时让他们完成情绪识别任务,并收集运动诱发电位(MEPs)。对于低度特质焦虑的参与者,负面和正面刺激的运动诱发电位振幅明显高于中性刺激。中度特质焦虑的参与者仅在受到负面刺激时的 MEP 振幅明显较高。高度特质焦虑的受试者在接受正面、负面和中性刺激时的 MEP 振幅无明显差异。特质焦虑得分与 MEP 振幅呈负相关:特质焦虑得分越高,MEP 振幅越大,对正面和负面刺激的情绪感知越低。研究结果表明,焦虑会损害与情绪感知相关的运动皮层兴奋性,首先是运动皮层对积极信息的兴奋性反应降低,随着焦虑程度的增加,运动皮层对消极信息的兴奋性反应也会降低。
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引用次数: 0
Qualitative Study on Emotional Experiences and Coping Strategies in Patients With COVID-19 During the Early Stage of Wuhan Crisis 武汉危机早期 COVID-19 患者的情绪体验和应对策略定性研究
IF 4.7 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-09-24 DOI: 10.1155/2024/6696049
Junyao Li, Huirong Luo, Wenli Tang, Hong Qian, Huiping Yang, Qinghua Luo

Objective: In the early stage of COVID-19 pandemic from December 2019 to March 2020, COVID-19 patients endured huge mental stress combined with constant physiological suffering. We aimed to summarize the emotional experiences of patients with COVID-19 during the early stages of the Wuhan crisis and present the coping strategies they used during the extreme time.

Methods: We did a qualitative study using an empirical phenomenology approach. COVID-19 patients with recovery and near discharge were recruited from the Dawu County Hospital of Traditional Chinese Medicine in Hubei province using purposive sampling. Semistructured face-to-face interviews were conducted by frontline medical staff and recorded by video and audio, then transcribed by two researchers separately. The Haase adapted version of the Colaizzi method was used to analyze the transcriptional data.

Results: We included 18 adult survivors of COVID-19 (33% female, 67% male) within the age range of 27–83 (mean age 48), and the average duration of isolation was 31.17 days. In conjunction with clinical data, we meticulously delved into the emotional trajectory of each survivor, spanning from the onset of illness through the phases of decline, improvement, and eventual recovery. Three theme categories were obtained from data analysis, including negative emotions and sources, coping strategies, and positive emotions and sources. COVID-19 patients adopted self-management strategies and received support from different roles when confronting high level of negative emotions.

Conclusions: Early survivors of COVID-19 experienced both negative and positive emotional experiences. Anxiety and other negative emotions were originated from both collective and individual concerns. The influence of the emotion sources differed at each stage of the disease. Patients coped with these stressors using external supports and self-adjustment. Still, comprehensive and targeted psychological services are needed.

目的:在2019年12月至2020年3月COVID-19大流行的早期阶段,COVID-19患者承受着巨大的精神压力和持续的生理痛苦。我们旨在总结 COVID-19 患者在武汉危机初期的情绪体验,并介绍他们在极端时期的应对策略。 研究方法我们采用经验现象学方法进行了一项定性研究。采用目的取样法,从湖北省大悟县中医院招募康复并接近出院的 COVID-19 患者。由一线医务人员进行面对面的半结构化访谈,并进行录像和录音,然后由两名研究人员分别进行转录。采用 Haase 改编版的 Colaizzi 方法对转录数据进行分析。 结果:我们纳入了 18 名 COVID-19 的成年幸存者(33% 为女性,67% 为男性),年龄范围在 27-83 岁之间(平均年龄为 48 岁),平均隔离时间为 31.17 天。结合临床数据,我们仔细研究了每位幸存者从发病到病情恶化、好转和最终康复的情感轨迹。数据分析得出了三个主题类别,包括消极情绪和来源、应对策略以及积极情绪和来源。COVID-19 患者在面对高度负面情绪时采取了自我管理策略,并从不同角色获得了支持。 结论COVID-19 的早期幸存者经历了消极和积极的情绪体验。焦虑和其他负面情绪源自集体和个人的担忧。在疾病的每个阶段,情绪源的影响都有所不同。患者通过外部支持和自我调整来应对这些压力。不过,我们仍然需要全面和有针对性的心理服务。
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引用次数: 0
Longitudinal Examination of Stress and Depression in Older Adults Over a 2-Year Period: Moderation Effect of Varied Social Support Measures 对老年人两年内的压力和抑郁进行纵向研究:各种社会支持措施的调节效应
IF 4.7 2区 医学 Q1 PSYCHIATRY Pub Date : 2024-09-24 DOI: 10.1155/2024/6462853
Jin-kyung Lee, Jinhee Lee, Sangwon Hwang, Moo-Kwon Chung, Ji Young Park, Taeksoo Shin, Kyoung-Joung Lee, Hyo-Sang Lim, Erdenebayar Urtnasan, Min-Hyuk Kim

Depressive symptoms and stress exposure fluctuate over time in community-dwelling older adults, but they are frequently assessed using one-time retrospective self-report measures. Social support viewed as a multifaceted construct can play diverse moderating roles in this association although it is typically gauged through the measure of perceived social support. This study aims to explore the relationships between stress, social support, and depressive symptoms among older adults by utilizing the longitudinal data collected through a smartphone application and supplemented by annual face-to-face interviews conducted over a 2-year period. Using longitudinal multilevel analysis, we analyzed the data on PHQ-9, stress exposure, and four distinct measures of social support collected from 354 community-dwelling older adults in South Korea. The results demonstrated that 59% of the variability in depressive symptoms was attributable to differences between individuals. Stress exposure was a strong predictor (γ = 3.01 ∗∗∗, 95% CI = 2.34–3.67). As expected, positive functional social support alleviated the effects of stress on depression (γ = −1.12 ∗∗, 95% CI = −1.92 ~ −0.32) while negative functional social support (γ = 2.36 ∗∗∗, 95% CI = 1.29–3.44) and negative structural social support (γ = 3.22 , 95% CI = 0.79–5.64) worsened the effects of stress on depression. A notable finding is that stress-amplifying effects from the negative functional and structural social support, in addition to well-known stress-buffering effects from positive functional social support, should be regarded as indispensable components in safeguarding the mental health of older adults. Considering the decline in social interactions and the lower probability of older adults establishing new social connections, it is essential to consider approaches that prevent a lack of functional and structural social support and foster a high-quality of functional and structural social support, particularly for those facing greater stressors, as a preventative method against depressive symptoms.

在社区居住的老年人中,抑郁症状和压力暴露会随着时间的推移而波动,但通常采用一次性回顾性自我报告方法对其进行评估。尽管社会支持通常是通过感知社会支持来衡量的,但社会支持作为一个多层面的概念,可以在这种关联中发挥不同的调节作用。本研究旨在利用通过智能手机应用程序收集的纵向数据,并辅以为期两年的年度面对面访谈,探讨老年人的压力、社会支持和抑郁症状之间的关系。通过纵向多层次分析,我们分析了从韩国 354 名居住在社区的老年人那里收集到的 PHQ-9、压力暴露和四种不同的社会支持测量数据。结果表明,抑郁症状59%的变化可归因于个体之间的差异。压力暴露是一个强有力的预测因素(γ = 3.01 ∗∗∗, 95% CI = 2.34-3.67)。正如预期的那样,积极的功能性社会支持会减轻压力对抑郁的影响(γ = -1.12 ∗∗∗, 95% CI = -1.92 ~ -0.32),而消极的功能性社会支持(γ = 2.36 ∗∗∗, 95% CI = 1.29-3.44)和消极的结构性社会支持(γ = 3.22 ∗∗, 95% CI = 0.79-5.64)会加重压力对抑郁的影响。一个值得注意的发现是,除了众所周知的积极功能性社会支持的压力缓冲作用外,消极功能性和结构性社会支持的压力放大效应应被视为保障老年人心理健康不可或缺的组成部分。考虑到社会交往的减少以及老年人建立新的社会联系的可能性降低,有必要考虑采取一些方法来防止功能性和结构性社会支持的缺乏,并促进高质量的功能性和结构性社会支持,特别是对于那些面临较大压力的老年人,以此作为预防抑郁症状的方法。
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Depression and Anxiety
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