This study aimed to assess if prostate-specific antigen (PSA) threshold and PSA bounce are associated with oncological control after low-dose-rate brachytherapy (LDR-BT) alone or with external beam radiotherapy (EBRT), with or without androgen deprivation therapy (ADT), considering serum testosterone levels.
METHODS
This study enrolled 944 prostate cancer patients treated at a single institution with LDR-BT alone or LDR-BT combined with EBRT, with or without ADT. The Fine-Gray hazard model was used to evaluate factors related to clinical failure, including experience of PSA bounce between baseline and 2, 4, or 7 years after LDR-BT and PSA value (0.1, 0.2, or 0.5 ng/mL) with normal testosterone levels at 2, 4, and 7 years after LDR-BT, respectively.
RESULTS
Patients with normal testosterone levels and a PSA of 0.2 or 0.5 ng/mL at 2, 4, and 7 years after LDR-BT had a significantly better clinical failure free rate (CFFR) than those with PSA levels >0.2 or >0.5 ng/mL or low testosterone levels. Multivariate analysis revealed that PSA <0.1, 0.2, or 0.5 ng/mL with normal testosterone levels at 2, 4, and 7 years and experience of PSA bounce between baseline and 2 or 4 years after LDR-BT were significantly related to better CFFR.
CONCLUSIONS
Patients with normal serum testosterone levels who reached PSA of <0.1, 0.2, or 0.5 ng/mL after LDR-BT, or those who experienced PSA bounce, showed better oncological control.
{"title":"Prostate-specific antigen (PSA) nadir and experience of PSA bounce after low-dose-rate brachytherapy for prostate cancer predicts clinical failure","authors":"Yasushi Nakai , Nobumichi Tanaka , Isao Asakawa , Kenta Onishi , Makito Miyake , Kaori Yamaki , Kiyohide Fujimoto","doi":"10.1016/j.brachy.2024.09.003","DOIUrl":"10.1016/j.brachy.2024.09.003","url":null,"abstract":"<div><h3>OBJECTIVE</h3><div>This study aimed to assess if prostate-specific antigen (PSA) threshold and PSA bounce are associated with oncological control after low-dose-rate brachytherapy (LDR-BT) alone or with external beam radiotherapy (EBRT), with or without androgen deprivation therapy (ADT), considering serum testosterone levels.</div></div><div><h3>METHODS</h3><div>This study enrolled 944 prostate cancer patients treated at a single institution with LDR-BT alone or LDR-BT combined with EBRT, with or without ADT. The Fine-Gray hazard model was used to evaluate factors related to clinical failure, including experience of PSA bounce between baseline and 2, 4, or 7 years after LDR-BT and PSA value (0.1, 0.2, or 0.5 ng/mL) with normal testosterone levels at 2, 4, and 7 years after LDR-BT, respectively.</div></div><div><h3>RESULTS</h3><div>Patients with normal testosterone levels and a PSA of 0.2 or 0.5 ng/mL at 2, 4, and 7 years after LDR-BT had a significantly better clinical failure free rate (CFFR) than those with PSA levels >0.2 or >0.5 ng/mL or low testosterone levels. Multivariate analysis revealed that PSA <0.1, 0.2, or 0.5 ng/mL with normal testosterone levels at 2, 4, and 7 years and experience of PSA bounce between baseline and 2 or 4 years after LDR-BT were significantly related to better CFFR.</div></div><div><h3>CONCLUSIONS</h3><div>Patients with normal serum testosterone levels who reached PSA of <0.1, 0.2, or 0.5 ng/mL after LDR-BT, or those who experienced PSA bounce, showed better oncological control.</div></div>","PeriodicalId":55334,"journal":{"name":"Brachytherapy","volume":"23 6","pages":"Pages 727-736"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-25DOI: 10.1016/j.brachy.2024.08.019
Grzegorz Bielęda PhD , Anna Marach MSc , Adam Chichel MD PhD , Natalia Langner MSc , Artur Chyrek MD PhD , Adam Kluska MD PhD , Wojciech Burchardt MD PhD , Grzegorz Zwierzchowski PhD
<div><h3>Purpose</h3><div>Contact brachytherapy for non-melanoma skin cancers demonstrates very good treatment results. The main problem is to fit properly a standard applicator to a heavily pleated surface, such as the nasal or orbital region. In order to improve the reproducibility and quality of dose distributions, we have introduced individual custom-designed applicators manufactured on a 3D printer. The purpose of this study was to verify the effect of changing the contoured CTV volume between the pre-plan and the therapeutic plan.</div></div><div><h3>Materials and Methods</h3><div>For the study, 95 consecutive treatment plans were qualified for patients treated between 2021 and 2023 with individual contact applicators for skin brachytherapy. After the qualification, on the first visit in brachytherapy department, the patient had fiducial radiological markers surrounding the skin lesion placed and the CT scan performed. On the images, the physician contoured the volume of the CTV and critical organs. Based on the CT images and contours, medical physicist prepared the body of the applicator, the position of the catheters and the optimal source dwell positions in treatment planning system. The proposed dose distribution was consulted with the physician for verification. After approval, the DICOM files were exported to software converting DICOM files to printable stl files and the applicator was printed. At the next visit, the patient was CT scanned with the applicator in place and a treatment plan was prepared, based on the recontoured CTV and critical organs. We compared CTV volume values and dose distribution values in reconstructed critical organs and CTV for the pre-plan and approved treatment plan. We considered CTV volume, V100, V150 and D90. For OARs we compared doses in 0.1, 1 and 2 ccm.</div></div><div><h3>Results</h3><div>Since the parameters studied did not show conformity to the normal distribution (the Shapiro-Wilk test was used) we applied the Wilcoxon signed-rank test. The compared parameters for the evaluation of the treatment plan appeared to be consistent with each other within the limits assumed for the tests performed (α=0.05), except for the maximum doses in the lenses. The doses in 0.1 cc of lens in the realized plans were found to be statistically significantly lower than in the plans created at the time of applicator design. Left lens pre-plan D0.1 = 12.86% vs 11.48% (p=0,005441) in treatment plan, right lens pre-plan D.01 = 9.67% vs 8.02% (p=0,005694) in treatment plan. During the preparation of the final treatment plans, physicists suspected physicians to contour larger CTV volumes than during the pre-plan and the applicator design. A surprising result of this study was that although not statistically significant but the mean CTV volume in the pre-plan was higher than in the contour made for the final treatment plan (1.69 ccm vs. 1.61 ccm). The main investigator thought before performing the statistics that the relati
{"title":"MPP05 Presentation Time: 4:45 PM","authors":"Grzegorz Bielęda PhD , Anna Marach MSc , Adam Chichel MD PhD , Natalia Langner MSc , Artur Chyrek MD PhD , Adam Kluska MD PhD , Wojciech Burchardt MD PhD , Grzegorz Zwierzchowski PhD","doi":"10.1016/j.brachy.2024.08.019","DOIUrl":"10.1016/j.brachy.2024.08.019","url":null,"abstract":"<div><h3>Purpose</h3><div>Contact brachytherapy for non-melanoma skin cancers demonstrates very good treatment results. The main problem is to fit properly a standard applicator to a heavily pleated surface, such as the nasal or orbital region. In order to improve the reproducibility and quality of dose distributions, we have introduced individual custom-designed applicators manufactured on a 3D printer. The purpose of this study was to verify the effect of changing the contoured CTV volume between the pre-plan and the therapeutic plan.</div></div><div><h3>Materials and Methods</h3><div>For the study, 95 consecutive treatment plans were qualified for patients treated between 2021 and 2023 with individual contact applicators for skin brachytherapy. After the qualification, on the first visit in brachytherapy department, the patient had fiducial radiological markers surrounding the skin lesion placed and the CT scan performed. On the images, the physician contoured the volume of the CTV and critical organs. Based on the CT images and contours, medical physicist prepared the body of the applicator, the position of the catheters and the optimal source dwell positions in treatment planning system. The proposed dose distribution was consulted with the physician for verification. After approval, the DICOM files were exported to software converting DICOM files to printable stl files and the applicator was printed. At the next visit, the patient was CT scanned with the applicator in place and a treatment plan was prepared, based on the recontoured CTV and critical organs. We compared CTV volume values and dose distribution values in reconstructed critical organs and CTV for the pre-plan and approved treatment plan. We considered CTV volume, V100, V150 and D90. For OARs we compared doses in 0.1, 1 and 2 ccm.</div></div><div><h3>Results</h3><div>Since the parameters studied did not show conformity to the normal distribution (the Shapiro-Wilk test was used) we applied the Wilcoxon signed-rank test. The compared parameters for the evaluation of the treatment plan appeared to be consistent with each other within the limits assumed for the tests performed (α=0.05), except for the maximum doses in the lenses. The doses in 0.1 cc of lens in the realized plans were found to be statistically significantly lower than in the plans created at the time of applicator design. Left lens pre-plan D0.1 = 12.86% vs 11.48% (p=0,005441) in treatment plan, right lens pre-plan D.01 = 9.67% vs 8.02% (p=0,005694) in treatment plan. During the preparation of the final treatment plans, physicists suspected physicians to contour larger CTV volumes than during the pre-plan and the applicator design. A surprising result of this study was that although not statistically significant but the mean CTV volume in the pre-plan was higher than in the contour made for the final treatment plan (1.69 ccm vs. 1.61 ccm). The main investigator thought before performing the statistics that the relati","PeriodicalId":55334,"journal":{"name":"Brachytherapy","volume":"23 6","pages":"Page S26"},"PeriodicalIF":1.7,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142527065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-25DOI: 10.1016/j.brachy.2024.08.054
Mayank Patel MD MBA , Samyukta Jhavar BS , Gaurav Gomber BS , Anne Hubbard MBA , Ann Klopp MD PhD , Andrew Farach MD , Michelle Ludwig MD MPH PhD
Purpose
Brachytherapy is a critical component of definitive cervical cancer treatment. Timely access to treatment has shown an improved survival benefit. Texas is the second largest state by size and population in the US. Here we explore the geographic availability of brachytherapy (BT) centers in the state.
Materials and Methods
We queried publicly available data on cervical cancer incidence and mortality between 2010-2020 from the Texas Cancer Registry. Available BT centers were compiled from the Texas Department of State Health Services (DSHS) Radiation Control Program and verified by direct contact with each treating institution. Number of BT units per 1,000 new cases was calculated as an index of BT availability.
Results
The state currently has 48 institutions actively treating cervical cancer with definitive tandem & ring/ovoid intracavitary BT. Texas DSHS geographically divided the state into 11 public health regions (PHR) to support and coordinate the local health needs of the entire state. PHR 8 located in the south-central region has the lowest availability of centers (1.23 centers/1,000 new cases), while PHR 1 in the north region has the highest availability (8.73 centers/1,000 new cases). The overall Texas incidence rate, mortality rate, and BT availability is 9.4 per 100,000 (US rate 7.7), 2.8 per 100,000 (US rate 2.6), and 3.43 per 1,000 new cases, respectively. In Texas, it is estimated that 45% of cases are diagnosed with locally advanced disease. The overall state locally advanced incidence rate is 4.2 cases per 100,000 population, which is 55% higher than the national locally advanced incidence rate of 2.7. Annually, 31% of all cervical cancer patients diagnosed in Texas die from the disease, as compared to only 10% nationally. On the county level, Henderson County has the highest mortality rate (5.8 deaths per 100,000 population) and no BT availability. Hidalgo County located on the southern border has the highest incidence (500) and deaths (157) of rural counties. Fort Bend County has the highest absolute incidence (263) and deaths (90) for a county without any BT centers. Angelina County has the highest incidence rate (15.9 per 100,000) with a non-zero death rate (3.9 per 100,000).
Conclusions
Compared to national rates, Texas has a higher overall incidence rate of cervical cancer overall and locally advanced cervical cancer highlighting the need for widespread access to BT services across the state. Herein, we review cervical cancer incidence rates, mortality rates, and access to intracavitary BT centers by county and PHR to identify BT deserts across the state. This analysis identifies the highest at-risk populations and opportunities for improved BT access. There is an existing need for expanded geographic access to high-quality BT centers and well-trained brachytherapists across Texas.
{"title":"GSOR08 Presentation Time: 5:35 PM","authors":"Mayank Patel MD MBA , Samyukta Jhavar BS , Gaurav Gomber BS , Anne Hubbard MBA , Ann Klopp MD PhD , Andrew Farach MD , Michelle Ludwig MD MPH PhD","doi":"10.1016/j.brachy.2024.08.054","DOIUrl":"10.1016/j.brachy.2024.08.054","url":null,"abstract":"<div><h3>Purpose</h3><div>Brachytherapy is a critical component of definitive cervical cancer treatment. Timely access to treatment has shown an improved survival benefit. Texas is the second largest state by size and population in the US. Here we explore the geographic availability of brachytherapy (BT) centers in the state.</div></div><div><h3>Materials and Methods</h3><div>We queried publicly available data on cervical cancer incidence and mortality between 2010-2020 from the Texas Cancer Registry. Available BT centers were compiled from the Texas Department of State Health Services (DSHS) Radiation Control Program and verified by direct contact with each treating institution. Number of BT units per 1,000 new cases was calculated as an index of BT availability.</div></div><div><h3>Results</h3><div>The state currently has 48 institutions actively treating cervical cancer with definitive tandem & ring/ovoid intracavitary BT. Texas DSHS geographically divided the state into 11 public health regions (PHR) to support and coordinate the local health needs of the entire state. PHR 8 located in the south-central region has the lowest availability of centers (1.23 centers/1,000 new cases), while PHR 1 in the north region has the highest availability (8.73 centers/1,000 new cases). The overall Texas incidence rate, mortality rate, and BT availability is 9.4 per 100,000 (US rate 7.7), 2.8 per 100,000 (US rate 2.6), and 3.43 per 1,000 new cases, respectively. In Texas, it is estimated that 45% of cases are diagnosed with locally advanced disease. The overall state locally advanced incidence rate is 4.2 cases per 100,000 population, which is 55% higher than the national locally advanced incidence rate of 2.7. Annually, 31% of all cervical cancer patients diagnosed in Texas die from the disease, as compared to only 10% nationally. On the county level, Henderson County has the highest mortality rate (5.8 deaths per 100,000 population) and no BT availability. Hidalgo County located on the southern border has the highest incidence (500) and deaths (157) of rural counties. Fort Bend County has the highest absolute incidence (263) and deaths (90) for a county without any BT centers. Angelina County has the highest incidence rate (15.9 per 100,000) with a non-zero death rate (3.9 per 100,000).</div></div><div><h3>Conclusions</h3><div>Compared to national rates, Texas has a higher overall incidence rate of cervical cancer overall and locally advanced cervical cancer highlighting the need for widespread access to BT services across the state. Herein, we review cervical cancer incidence rates, mortality rates, and access to intracavitary BT centers by county and PHR to identify BT deserts across the state. This analysis identifies the highest at-risk populations and opportunities for improved BT access. There is an existing need for expanded geographic access to high-quality BT centers and well-trained brachytherapists across Texas.</div></div>","PeriodicalId":55334,"journal":{"name":"Brachytherapy","volume":"23 6","pages":"Pages S45-S46"},"PeriodicalIF":1.7,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142527138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-25DOI: 10.1016/j.brachy.2024.08.072
Yhana Chavis DO, Kristin Walker MD MBA, Allen Luk MD, Daniel Leach MD, Kara Romano MD, Einsley Janowski MD PhD
<div><h3>Purpose</h3><div>Brachytherapy (BT) boost is the standard of care technique for locally advanced cervical cancer (LACC) and a critical component of curative treatment. Overall treatment time strongly correlates with local control, with evidence indicating that completion of chemoradiation within 8 weeks is important for clinical outcomes. Socioeconomic and racial factors are also known to contribute to disparities in BT access and have been linked to worsened survival. The aim of our study is to explore factors impacting timely completion of BT treatment amongst LACC patients treated at a single academic institution that serves a large catchment area in the state of Virginia.</div></div><div><h3>Methods</h3><div>Patients diagnosed with LACC receiving their BT at the University of Virginia (UVA) between 2004 and 2021 were identified. Patient demographics and additional characteristics were recorded, including: insurance and employment status, alcohol and/or drug use disorder, and distance from UVA Cancer Center. Based on proven prognostic factors for local control of LACC, the cut off of 56 days to complete treatment was used for stratification, looking at demographic differences between those groups who received timely or prolonged therapy completion. The means for each demographic were compared using standard error and simple unpaired t-tests.</div></div><div><h3>Results</h3><div>124 patients with LACC, FIGO stage IB2 to IV were included Median age of our cohort at time of treatment was 49.8 years. 50% of patients were employed, 42% were unemployed, and 8% had unknown employment status. 79% of patients had listed insurance, 11% had no insurance, and 10% had unknown insurance information. Racial demographics were 74% white, 15% black, 9% Hispanic, 2% Asian, and <1% unidentified. 4% of patients had a history of incarceration, 3% of patients had a known history of or current drug abuse, and 2 of the above patients had both factors. Out of the 124 patients, 24 patients completed concurrent chemoradiation and BT beyond 56 days. The statistically significant social barriers identified in this group included employment, insurance status, and drug use. Employed patients completed treatment on an average of 49.7 ± 1.1 days (range 36-79), compared to 51.44 days ± 1.5 days (range 34-87) for unemployed patients <em>(p</em> = 0.0135). Insured patients completed their treatment within 50.6 ± 0.9 days (range 43-71), compared to 59.14 ± 1.9 days (range 34-87) for uninsured, (<em>p</em> = 0.035). On average, white, Hispanic, and black women completed treatment in 50.9 ± 1.02 days, 48.9 ± 1.58 days, and 54.0 ± 2.5 days, respectively (<em>p</em>=0.20 for white versus black cohorts). Average completion time was 50.6 ± 0.9 (range 34-87) in the non-incarcerated group compared to 55 ± 5 days (range 47-70) in the incarcerated group, <em>p</em> =0.32, and average completion time was 50.3 ± 0.9 days (range 34-87) in the non-drug use compared to 65.5 ± 2.1 day
{"title":"MSOR10 Presentation Time: 8:45 AM","authors":"Yhana Chavis DO, Kristin Walker MD MBA, Allen Luk MD, Daniel Leach MD, Kara Romano MD, Einsley Janowski MD PhD","doi":"10.1016/j.brachy.2024.08.072","DOIUrl":"10.1016/j.brachy.2024.08.072","url":null,"abstract":"<div><h3>Purpose</h3><div>Brachytherapy (BT) boost is the standard of care technique for locally advanced cervical cancer (LACC) and a critical component of curative treatment. Overall treatment time strongly correlates with local control, with evidence indicating that completion of chemoradiation within 8 weeks is important for clinical outcomes. Socioeconomic and racial factors are also known to contribute to disparities in BT access and have been linked to worsened survival. The aim of our study is to explore factors impacting timely completion of BT treatment amongst LACC patients treated at a single academic institution that serves a large catchment area in the state of Virginia.</div></div><div><h3>Methods</h3><div>Patients diagnosed with LACC receiving their BT at the University of Virginia (UVA) between 2004 and 2021 were identified. Patient demographics and additional characteristics were recorded, including: insurance and employment status, alcohol and/or drug use disorder, and distance from UVA Cancer Center. Based on proven prognostic factors for local control of LACC, the cut off of 56 days to complete treatment was used for stratification, looking at demographic differences between those groups who received timely or prolonged therapy completion. The means for each demographic were compared using standard error and simple unpaired t-tests.</div></div><div><h3>Results</h3><div>124 patients with LACC, FIGO stage IB2 to IV were included Median age of our cohort at time of treatment was 49.8 years. 50% of patients were employed, 42% were unemployed, and 8% had unknown employment status. 79% of patients had listed insurance, 11% had no insurance, and 10% had unknown insurance information. Racial demographics were 74% white, 15% black, 9% Hispanic, 2% Asian, and <1% unidentified. 4% of patients had a history of incarceration, 3% of patients had a known history of or current drug abuse, and 2 of the above patients had both factors. Out of the 124 patients, 24 patients completed concurrent chemoradiation and BT beyond 56 days. The statistically significant social barriers identified in this group included employment, insurance status, and drug use. Employed patients completed treatment on an average of 49.7 ± 1.1 days (range 36-79), compared to 51.44 days ± 1.5 days (range 34-87) for unemployed patients <em>(p</em> = 0.0135). Insured patients completed their treatment within 50.6 ± 0.9 days (range 43-71), compared to 59.14 ± 1.9 days (range 34-87) for uninsured, (<em>p</em> = 0.035). On average, white, Hispanic, and black women completed treatment in 50.9 ± 1.02 days, 48.9 ± 1.58 days, and 54.0 ± 2.5 days, respectively (<em>p</em>=0.20 for white versus black cohorts). Average completion time was 50.6 ± 0.9 (range 34-87) in the non-incarcerated group compared to 55 ± 5 days (range 47-70) in the incarcerated group, <em>p</em> =0.32, and average completion time was 50.3 ± 0.9 days (range 34-87) in the non-drug use compared to 65.5 ± 2.1 day","PeriodicalId":55334,"journal":{"name":"Brachytherapy","volume":"23 6","pages":"Pages S55-S56"},"PeriodicalIF":1.7,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-25DOI: 10.1016/j.brachy.2024.08.046
Felipe Castro Canovas MD, DRCPSC, Carlos Herrera Castillo MSc, Eduardo Carrasco Solis MSc, Yesenia Miranda Tunque MD, Luis Gamarra Delgado MD, Indranit Revilla Coz MD, Gustavo Lasteros Ayma MD, Juan Manuel Trejo Mena MD, Herbert Cardenas Del Carpio MD, Paola Fuentes-Rivera Carmelo MD, Alberto Lachos Davila MD, Adela Heredia Zelaya MD, Karinthia Ballon Cervantes MD
Purpose
This single-institution proof of concept and early experience on an innovative workflow for the creation of custom applicators for high dose rate (HDR) skin brachytherapy and skin bolus in low to middle-income countries, where access to CT simulation or dedicated surface scanners is sparse, we utilized geometry mapping technology found in many readily available smartphones as an alternative to other design methods, reducing the number of CT-simulations needed from two to one, improving access to custom applicators for more patients. We now report our skin brachytherapy early experience.
Materials and Methods
In selected consenting patients with indication for skin brachytherapy or EBRT, a smartphone front camera system (e.g. Apple iPhone X or newer with TrueDepth camera) was used to capture the skin surface with capturing software (Apple iOS - Heges 3D Scanner by Marek Simonik), then exported to a computer-aided design software to blueprint the applicator (Meshmixer and Fusion 360 Autodesk on Apple MacOS or Microsoft Windows). The applicator was then 3D printed in-house using a fused deposition modeling printer (Flashforge Adventure 3) with polylactic Acid (PLA) material. The applicator completed a quality assurance examination and then fitted to the patient for a single CT simulation for planning (SagiPlan®), quality assurance and treatment delivery with a Cobalt - 60 after loader (SagiNova®). Follow-up was conducted per standard institutional protocol, and Common Terminology Criteria for Adverse Events Version 5.0 (CTCAE) was used to report toxicities.
Results
From July 2023 to January 2024, 05 patients were scanned, 4 patients received a 3D printed custom bolus for EBRT, and 1 patient received a custom HDR skin brachytherapy custom applicator, the one patient treated with HDR brachytherapy is reported, had basal cell carcinoma of the nose, the prescription dose was 40Gy in 10 fractions delivered daily, 100% isodose line encapsulated the PTV, limiting surface dose <150%. Acute grade 1 skin toxicity was observed at the end of treatment, it completely resolved at 3 months. No late toxicity or recurrence was observed at 6 months.
Conclusions
This small, early-reported experience with a novel workflow seems faceable and safe, potentially allowing less congestion at the CT Sim, improving access for more patients in low to middle-income countries to custom 3D printed accessories. A larger number of patients and longer follow-ups are needed, report on 3D EBRT bolus results to follow.
目的在中低收入国家，CT 模拟或专用表面扫描仪非常稀缺，我们利用许多现成的智能手机中的几何图形映射技术替代其他设计方法，将所需的 CT 模拟次数从两次减少到一次，让更多患者获得了定制涂抹器。材料与方法在选定的有皮肤近距离放射治疗或 EBRT 适应症的同意患者中，使用智能手机前置摄像头系统（如配备 TrueDepth 摄像头的苹果 iPhone X 或更新机型），通过捕捉软件（苹果 iOS - Marek Simonik 的 Heges 3D 扫描仪）捕捉皮肤表面，然后导出到计算机辅助设计软件，绘制涂抹器蓝图（苹果 MacOS 或微软 Windows 上的 Meshmixer 和 Fusion 360 Autodesk）。然后使用内部的熔融沉积建模打印机（Flashforge Adventure 3）和聚乳酸（PLA）材料对涂抹器进行三维打印。敷贴器完成了质量保证检查，然后安装到患者身上，进行单次 CT 模拟规划 (SagiPlan®)、质量保证和使用 Cobalt - 60 后装载器 (SagiNova®) 进行治疗。按照标准机构协议进行随访，并使用《不良事件通用术语标准 5.0 版》（CTCAE）报告毒性。结果从2023年7月到2024年1月，共扫描了05名患者，4名患者接受了3D打印定制的EBRT栓剂，1名患者接受了定制的HDR皮肤近距离放射治疗定制涂抹器，报告的1名接受HDR近距离放射治疗的患者患有鼻基底细胞癌，处方剂量为40Gy，每天分10次给药，100%等剂量线包裹PTV，限制表面剂量<150%。治疗结束时出现急性 1 级皮肤毒性，3 个月后完全消退。结论这种新型工作流程的早期小规模经验似乎是可面对的、安全的，有可能减少 CT Sim 的拥堵，让更多中低收入国家的患者获得定制的 3D 打印配件。还需要更多患者和更长时间的随访，有关 3D EBRT 栓剂结果的报告将在随后公布。
{"title":"MSOR12 Presentation Time: 5:55 PM","authors":"Felipe Castro Canovas MD, DRCPSC, Carlos Herrera Castillo MSc, Eduardo Carrasco Solis MSc, Yesenia Miranda Tunque MD, Luis Gamarra Delgado MD, Indranit Revilla Coz MD, Gustavo Lasteros Ayma MD, Juan Manuel Trejo Mena MD, Herbert Cardenas Del Carpio MD, Paola Fuentes-Rivera Carmelo MD, Alberto Lachos Davila MD, Adela Heredia Zelaya MD, Karinthia Ballon Cervantes MD","doi":"10.1016/j.brachy.2024.08.046","DOIUrl":"10.1016/j.brachy.2024.08.046","url":null,"abstract":"<div><h3>Purpose</h3><div>This single-institution proof of concept and early experience on an innovative workflow for the creation of custom applicators for high dose rate (HDR) skin brachytherapy and skin bolus in low to middle-income countries, where access to CT simulation or dedicated surface scanners is sparse, we utilized geometry mapping technology found in many readily available smartphones as an alternative to other design methods, reducing the number of CT-simulations needed from two to one, improving access to custom applicators for more patients. We now report our skin brachytherapy early experience.</div></div><div><h3>Materials and Methods</h3><div>In selected consenting patients with indication for skin brachytherapy or EBRT, a smartphone front camera system (e.g. Apple iPhone X or newer with TrueDepth camera) was used to capture the skin surface with capturing software (Apple iOS - Heges 3D Scanner by Marek Simonik), then exported to a computer-aided design software to blueprint the applicator (Meshmixer and Fusion 360 Autodesk on Apple MacOS or Microsoft Windows). The applicator was then 3D printed in-house using a fused deposition modeling printer (Flashforge Adventure 3) with polylactic Acid (PLA) material. The applicator completed a quality assurance examination and then fitted to the patient for a single CT simulation for planning (SagiPlan®), quality assurance and treatment delivery with a Cobalt - 60 after loader (SagiNova®). Follow-up was conducted per standard institutional protocol, and Common Terminology Criteria for Adverse Events Version 5.0 (CTCAE) was used to report toxicities.</div></div><div><h3>Results</h3><div>From July 2023 to January 2024, 05 patients were scanned, 4 patients received a 3D printed custom bolus for EBRT, and 1 patient received a custom HDR skin brachytherapy custom applicator, the one patient treated with HDR brachytherapy is reported, had basal cell carcinoma of the nose, the prescription dose was 40Gy in 10 fractions delivered daily, 100% isodose line encapsulated the PTV, limiting surface dose <150%. Acute grade 1 skin toxicity was observed at the end of treatment, it completely resolved at 3 months. No late toxicity or recurrence was observed at 6 months.</div></div><div><h3>Conclusions</h3><div>This small, early-reported experience with a novel workflow seems faceable and safe, potentially allowing less congestion at the CT Sim, improving access for more patients in low to middle-income countries to custom 3D printed accessories. A larger number of patients and longer follow-ups are needed, report on 3D EBRT bolus results to follow.</div></div>","PeriodicalId":55334,"journal":{"name":"Brachytherapy","volume":"23 6","pages":"Page S41"},"PeriodicalIF":1.7,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-25DOI: 10.1016/j.brachy.2024.08.017
Tamer Soror MD, PhD , Pierre-Alexander Justenhoven MD , Anke Leichtle MD, PhD , Karl-Ludwig Bruchhage MD, PhD , György Kovács MD, PhD , Dirk Rades MD, PhD
<div><h3>Purpose</h3><div>Periorificial facial cancer (PFC), characterized by cancer originating from the eyelids, nasal vestibule, lips, and ear lobules, exhibits significantly high global incidence rates. Radical surgery have both functional and aesthetic complications. This retrospective analysis explores the effectiveness of high-dose-rate interventional radiotherapy (HDR-IRT, brachytherapy) combined with organ-preserving surgery for managing PFC.</div></div><div><h3>Material and Methods</h3><div>We conducted a retrospective assessment of patients with PFC and treated with HDR-IRT at our center between 2008 and 2022. Patients underwent a physical examination, tumor biopsy, and head-and-neck CT and/or MRI for locoregional staging. The decision of organ-preserving surgery with HDR-IRT was made by a specialized multidisciplinary tumor board. Organ-preserving surgery ranged from tumor debulking to complete local resection. HDR-IRT catheters were immediately implanted in the operating room, in a parallel arrangement with 8-12 mm spacing. The clinical target volume included the estimated tumor volume and a safety margin (5-15 mm) based on anatomical considerations and nearby critical structures. The prescribed radiation dose was administered twice daily with a minimum six-hour gap between fractions. The median HDR-IRT dose was 40Gy (30-50), the median fraction dose was 4Gy (2.5-5), and the median number of fractions was 10 (8-16). Treatment-related toxicities were assessed according to the Common Terminology Criteria for Adverse Events (CTCAE) version 5.0.</div></div><div><h3>Results</h3><div>A total of 123 patients were identified, with primary sites as follows: 24 (19.5%) eyelids, 58 (47.2%) nasal vestibule, 25 (20.3%) lips, and 16 (13%) ear lobules. The median age was 76 years (37-99), with 60.2% (74/123) males and 39.2% (49/123) females. Sixty-four percent (64.2%) had primary tumors, and 35.8% had recurrent tumors. Among patients with recurrent tumors, 40 had previous surgery, and four were primarily treated with EBRT. Debulking surgery was performed in 16 patients (13%), and neck dissection in 14 patients (11.4%). Among 107 patients undergoing local resection, eight had close surgical margins, 40 had positive margins, and four had macroscopic residuals. T-status included T1 (53.7%), T2 (28.5%), T3 (10.5%), and T4 (7.3%). Six patients had positive neck lymph nodes. Squamous cell carcinoma constituted 61.8%, basal cell carcinoma 30.9%, and other histologies 7.3%. The median follow-up time was 38 months (4-147). During follow-up, 15 local recurrences (12.2%) were documented, with a median time to recurrence of 13 months (5-71). Local recurrence rates by tumor site were as follows: Nose 10/58 (17.2%), eyelid 3/24 (12.5%), lip 1/25 (4%), and ear lobule 1/16 (6.3%). The 5-year local control (LC) rate was 85.3%, with 10-year and 12-year LC rates of 80.8%. Five-year, 10-year, and 12-year disease-free survival (DFS) rates were 87.8%. Five-year distant
{"title":"MPP03 Presentation Time: 4:18 PM","authors":"Tamer Soror MD, PhD , Pierre-Alexander Justenhoven MD , Anke Leichtle MD, PhD , Karl-Ludwig Bruchhage MD, PhD , György Kovács MD, PhD , Dirk Rades MD, PhD","doi":"10.1016/j.brachy.2024.08.017","DOIUrl":"10.1016/j.brachy.2024.08.017","url":null,"abstract":"<div><h3>Purpose</h3><div>Periorificial facial cancer (PFC), characterized by cancer originating from the eyelids, nasal vestibule, lips, and ear lobules, exhibits significantly high global incidence rates. Radical surgery have both functional and aesthetic complications. This retrospective analysis explores the effectiveness of high-dose-rate interventional radiotherapy (HDR-IRT, brachytherapy) combined with organ-preserving surgery for managing PFC.</div></div><div><h3>Material and Methods</h3><div>We conducted a retrospective assessment of patients with PFC and treated with HDR-IRT at our center between 2008 and 2022. Patients underwent a physical examination, tumor biopsy, and head-and-neck CT and/or MRI for locoregional staging. The decision of organ-preserving surgery with HDR-IRT was made by a specialized multidisciplinary tumor board. Organ-preserving surgery ranged from tumor debulking to complete local resection. HDR-IRT catheters were immediately implanted in the operating room, in a parallel arrangement with 8-12 mm spacing. The clinical target volume included the estimated tumor volume and a safety margin (5-15 mm) based on anatomical considerations and nearby critical structures. The prescribed radiation dose was administered twice daily with a minimum six-hour gap between fractions. The median HDR-IRT dose was 40Gy (30-50), the median fraction dose was 4Gy (2.5-5), and the median number of fractions was 10 (8-16). Treatment-related toxicities were assessed according to the Common Terminology Criteria for Adverse Events (CTCAE) version 5.0.</div></div><div><h3>Results</h3><div>A total of 123 patients were identified, with primary sites as follows: 24 (19.5%) eyelids, 58 (47.2%) nasal vestibule, 25 (20.3%) lips, and 16 (13%) ear lobules. The median age was 76 years (37-99), with 60.2% (74/123) males and 39.2% (49/123) females. Sixty-four percent (64.2%) had primary tumors, and 35.8% had recurrent tumors. Among patients with recurrent tumors, 40 had previous surgery, and four were primarily treated with EBRT. Debulking surgery was performed in 16 patients (13%), and neck dissection in 14 patients (11.4%). Among 107 patients undergoing local resection, eight had close surgical margins, 40 had positive margins, and four had macroscopic residuals. T-status included T1 (53.7%), T2 (28.5%), T3 (10.5%), and T4 (7.3%). Six patients had positive neck lymph nodes. Squamous cell carcinoma constituted 61.8%, basal cell carcinoma 30.9%, and other histologies 7.3%. The median follow-up time was 38 months (4-147). During follow-up, 15 local recurrences (12.2%) were documented, with a median time to recurrence of 13 months (5-71). Local recurrence rates by tumor site were as follows: Nose 10/58 (17.2%), eyelid 3/24 (12.5%), lip 1/25 (4%), and ear lobule 1/16 (6.3%). The 5-year local control (LC) rate was 85.3%, with 10-year and 12-year LC rates of 80.8%. Five-year, 10-year, and 12-year disease-free survival (DFS) rates were 87.8%. Five-year distant ","PeriodicalId":55334,"journal":{"name":"Brachytherapy","volume":"23 6","pages":"Pages S24-S25"},"PeriodicalIF":1.7,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<div><h3>Purpose</h3><div>Consensus recommendations for CT based contouring in Image Guided Adaptive Brachytherapy (CT-IGABT) for cervical cancer were published by IBS-GEC ESTRO-ABS. However, real world outcome data of patients treated based on these recommendations is sparse. The purpose of this study is to present early outcomes of cervical cancer patients treated with CT-IGABT using the IBS-GEC ESTRO-ABS recommendations.</div></div><div><h3>Material and Methods</h3><div>Retro-LACER is a mono-institutional database of cervical cancer patients treated with CT-IGABT using uniform target delineation protocols between August 2020 and July 2023. All consecutive patients with biopsy proven locally advanced cervical cancer (FIGO Stage IB3 to IVA) who received curative (chemo) radiation at our institution were screened. While the dosimetric details were maintained prospectively, outcome and treatment related morbidity data is collected retrospectively from the electronic medical records.</div></div><div><h3>Results</h3><div>Out of 318 patients screened, 73 were excluded as per the eligibility criteria (2, stage ≤ IB2; 3 stage IVB; 19, received EBRT elsewhere; 17 defaulted / received BT elsewhere; 21, participants in other interventional studies; 11, did not come for at least one post treatment follow up). Disease and treatment characteristics of the 245 patients included in this analysis are presented in Table 1. Hybrid IC+IS BT was used in 51.4% of patients. About 64.5% of patients were treated in a basic CT environment (CT alone at BT), while 35.5% were treated in an advanced CT environment (pre-BT MRI, in 3.6% and Trans-Rectal ultrasonography in 31.8%). Median volume of CTV_HR was 31cc, while median D90 and D98 to CTV_HR (in EQD2<sub>10Gy</sub>) were 88 and 79, respectively. Median D2cc for bladder, rectum and sigmoid (in EQD2<sub>3Gy</sub>) were 89, 68 and 67, respectively. Dosimetric details of patients treated in basic and advanced CT environments are also presented in Table 1. At a median follow up of 17 months (IQR, 9 to 26), 12 patients (4.9%) died due to disease and 3 (1.2%) were lost to follow up. Treatment failure was observed in 27 patients (11%), with isolated local, regional (pelvic), regional (para-aortic), regional (pelvic + para-aortic) and distant failures in 3 (1.2%), 0 (0%), 5 (2%), 1 (0.4 %) and 12 (5.2%) respectively. Combination of [local + regional], [regional + distant] and [local + regional + distant] failures was observed in 2 (0.8%), 3 (1.2%) and 1 (0.4%) respectively. Estimated survival probability (Kaplan-Meier) at 6 months and 1 year were 99.5% and 93% for local control, 99.1% and 92% for loco-regional relapse free survival and 100% and 95% for overall survival, respectively. Severe late GI and GU morbidity (CTCAEv5 ≥ Grade 3) was observed in 18 (7.3%) and 1 (0.4%), respectively. Among the patients who developed severe late GU and GI morbidity, median D2cc doses to bladder, rectum and sigmoid (in EQD2<sub>3Gy</sub>) were
{"title":"GPP06 Presentation Time: 9:45 AM","authors":"Raviteja Miriyala M.D , KK Sreelakshmi M.Sc.,D.R.P , Kiriti Chiriki D.N.B , Raghavendra Hajare M.Sc., D.R.P , Rohit Vadgaonkar M.D , Sneha Nachu B.D.S , Surbhi Grover M.D , Umesh Mahantshetty M.D, D.N.B","doi":"10.1016/j.brachy.2024.08.008","DOIUrl":"10.1016/j.brachy.2024.08.008","url":null,"abstract":"<div><h3>Purpose</h3><div>Consensus recommendations for CT based contouring in Image Guided Adaptive Brachytherapy (CT-IGABT) for cervical cancer were published by IBS-GEC ESTRO-ABS. However, real world outcome data of patients treated based on these recommendations is sparse. The purpose of this study is to present early outcomes of cervical cancer patients treated with CT-IGABT using the IBS-GEC ESTRO-ABS recommendations.</div></div><div><h3>Material and Methods</h3><div>Retro-LACER is a mono-institutional database of cervical cancer patients treated with CT-IGABT using uniform target delineation protocols between August 2020 and July 2023. All consecutive patients with biopsy proven locally advanced cervical cancer (FIGO Stage IB3 to IVA) who received curative (chemo) radiation at our institution were screened. While the dosimetric details were maintained prospectively, outcome and treatment related morbidity data is collected retrospectively from the electronic medical records.</div></div><div><h3>Results</h3><div>Out of 318 patients screened, 73 were excluded as per the eligibility criteria (2, stage ≤ IB2; 3 stage IVB; 19, received EBRT elsewhere; 17 defaulted / received BT elsewhere; 21, participants in other interventional studies; 11, did not come for at least one post treatment follow up). Disease and treatment characteristics of the 245 patients included in this analysis are presented in Table 1. Hybrid IC+IS BT was used in 51.4% of patients. About 64.5% of patients were treated in a basic CT environment (CT alone at BT), while 35.5% were treated in an advanced CT environment (pre-BT MRI, in 3.6% and Trans-Rectal ultrasonography in 31.8%). Median volume of CTV_HR was 31cc, while median D90 and D98 to CTV_HR (in EQD2<sub>10Gy</sub>) were 88 and 79, respectively. Median D2cc for bladder, rectum and sigmoid (in EQD2<sub>3Gy</sub>) were 89, 68 and 67, respectively. Dosimetric details of patients treated in basic and advanced CT environments are also presented in Table 1. At a median follow up of 17 months (IQR, 9 to 26), 12 patients (4.9%) died due to disease and 3 (1.2%) were lost to follow up. Treatment failure was observed in 27 patients (11%), with isolated local, regional (pelvic), regional (para-aortic), regional (pelvic + para-aortic) and distant failures in 3 (1.2%), 0 (0%), 5 (2%), 1 (0.4 %) and 12 (5.2%) respectively. Combination of [local + regional], [regional + distant] and [local + regional + distant] failures was observed in 2 (0.8%), 3 (1.2%) and 1 (0.4%) respectively. Estimated survival probability (Kaplan-Meier) at 6 months and 1 year were 99.5% and 93% for local control, 99.1% and 92% for loco-regional relapse free survival and 100% and 95% for overall survival, respectively. Severe late GI and GU morbidity (CTCAEv5 ≥ Grade 3) was observed in 18 (7.3%) and 1 (0.4%), respectively. Among the patients who developed severe late GU and GI morbidity, median D2cc doses to bladder, rectum and sigmoid (in EQD2<sub>3Gy</sub>) were","PeriodicalId":55334,"journal":{"name":"Brachytherapy","volume":"23 6","pages":"Page S19"},"PeriodicalIF":1.7,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-25DOI: 10.1016/j.brachy.2024.08.085
Juanjuan Fu MS, Zhaobin Li MS, Zhen Li MS, Jie Fu MD
Purpose
This study focuses on determining the optimal MRI scanning parameters for precise localization of MR-line markers, and to investigate their apical reconstruction error.
Materials and Methods
In the study, it was assumed that the front seal of each MR-line marker was identical. Three MR-line markers were individually placed at the tips inside the tubes of plastic sharp needles. The position of the plastic-tipped sharp needles was marked with three additional MR-line markers. These needles, along with the markers, were then fixed into the same L-shaped (rectangular) mold to ensure that the plastic sharp needles and their corresponding MR-line markers maintained a stable, horizontal alignment and were immobilized during the process. The physical distance measured between the tips of the two MR line markers, one located inside and the other outside the plastic sharp needle, was approximately 2.30mm. To evaluate the apical reconstruction error of the MR-line marker,10 sets of MR images were acquired with varying slice thicknesses, including T1-weighted images with thicknesses of 3 mm, 2 mm, and 1.4 mm, and T2 -weighted images with thicknesses of 3 mm, 2 mm, and 1 mm.
Results
The analysis of the image distance between the MR-line marker tips, both inside and outside plastic sharp needle, revealed that the probability of the measurement of the MR-line marker being within 1 mm accuracy was 92.59%. It was observed that the thickness of the MR images positively correlated with both the mean and standard deviation of the image measurement value in T1-weighted scans. Additionally, the standard deviation of MR-line marker image measurements in T2-weighted scans showed a slight increase as the layer thickness was reduced to 2mm. Upon comparing the results from the three sets of MR-line marker image measurements, it was found that the overall results of T2-weighted scans at 3 mm and T1-weighted scans at 1.4 mm were similar. However, it is important to note that the thinner slice parameter not only restricts the length of the scan, but also leads to increased scanning time and additional time required for contouring before brachytherapy treatment, resulting in increased discomfort for the patient. Therefore, a scanning parameter of T2-weighted scans at 3 mm is recommended for the reconstruction of the MR-line marker.
Conclusions
The study demonstrated that the MR-line marker possesses significant potential for clinical application, particularly in the precise localization of plastic sharp needles. This finding is pivotal as it provides a crucial experimental foundation for the implementation of an MR-only workflow in interstitial gynecologic brachytherapy.
{"title":"PHSOR11 Presentation Time: 9:50 AM","authors":"Juanjuan Fu MS, Zhaobin Li MS, Zhen Li MS, Jie Fu MD","doi":"10.1016/j.brachy.2024.08.085","DOIUrl":"10.1016/j.brachy.2024.08.085","url":null,"abstract":"<div><h3>Purpose</h3><div>This study focuses on determining the optimal MRI scanning parameters for precise localization of MR-line markers, and to investigate their apical reconstruction error.</div></div><div><h3>Materials and Methods</h3><div>In the study, it was assumed that the front seal of each MR-line marker was identical. Three MR-line markers were individually placed at the tips inside the tubes of plastic sharp needles. The position of the plastic-tipped sharp needles was marked with three additional MR-line markers. These needles, along with the markers, were then fixed into the same L-shaped (rectangular) mold to ensure that the plastic sharp needles and their corresponding MR-line markers maintained a stable, horizontal alignment and were immobilized during the process. The physical distance measured between the tips of the two MR line markers, one located inside and the other outside the plastic sharp needle, was approximately 2.30mm. To evaluate the apical reconstruction error of the MR-line marker,10 sets of MR images were acquired with varying slice thicknesses, including T1-weighted images with thicknesses of 3 mm, 2 mm, and 1.4 mm, and T2 -weighted images with thicknesses of 3 mm, 2 mm, and 1 mm.</div></div><div><h3>Results</h3><div>The analysis of the image distance between the MR-line marker tips, both inside and outside plastic sharp needle, revealed that the probability of the measurement of the MR-line marker being within 1 mm accuracy was 92.59%. It was observed that the thickness of the MR images positively correlated with both the mean and standard deviation of the image measurement value in T1-weighted scans. Additionally, the standard deviation of MR-line marker image measurements in T2-weighted scans showed a slight increase as the layer thickness was reduced to 2mm. Upon comparing the results from the three sets of MR-line marker image measurements, it was found that the overall results of T2-weighted scans at 3 mm and T1-weighted scans at 1.4 mm were similar. However, it is important to note that the thinner slice parameter not only restricts the length of the scan, but also leads to increased scanning time and additional time required for contouring before brachytherapy treatment, resulting in increased discomfort for the patient. Therefore, a scanning parameter of T2-weighted scans at 3 mm is recommended for the reconstruction of the MR-line marker.</div></div><div><h3>Conclusions</h3><div>The study demonstrated that the MR-line marker possesses significant potential for clinical application, particularly in the precise localization of plastic sharp needles. This finding is pivotal as it provides a crucial experimental foundation for the implementation of an MR-only workflow in interstitial gynecologic brachytherapy.</div></div>","PeriodicalId":55334,"journal":{"name":"Brachytherapy","volume":"23 6","pages":"Pages S63-S64"},"PeriodicalIF":1.7,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142527289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-25DOI: 10.1016/j.brachy.2024.08.047
Dulce M. Barrios MD , Mitchell Kamrava MD , Jenna M. Kahn MD , Vonetta M. Williams MD , Keyur J. Mehta MD , Aaron Wolfson MD , Lorraine Portelance MD , Amanda Rivera MD
<div><h3>Purpose</h3><div>To determine the current practice patterns of analgesia (AG) and anesthesia (AS) use across the U.S. for gynecologic brachytherapy (BT) procedures.</div></div><div><h3>Methods and Materials</h3><div>A 27-item survey was created with expertise from five practicing radiation oncology brachytherapists in the U.S. and distributed electronically to 90 Radiation Oncology residency programs for dissemination. The survey was also publicized on social media via the X (formally Twitter) platform, and at two national meetings (The American Brachytherapy Society Annual Meeting 2023 and The American Society for Radiation Therapy Annual Meeting 2023) during the months of June-October 2023.</div></div><div><h3>Results</h3><div>Forty-one responses were received (46% response rate). Fifty-four percent identified as female, 66% Caucasian race and 85% of non-Hispanic/Latino ethnicity. Ninety-three percent were physician brachytherapists, 5% medical physicists, and 2% did not disclose their profession. Forty nine percent reported typically carrying out procedures in a BT suite ± separate CT simulator alone, 39% in the operating room ± BT suite or CT simulator or other location. Ten percent reported the CT simulation room alone, and 2% in a clinic exam room. The number of cervix BT courses most frequently performed per month was between 0 and 5 at 61%, and 44% reported an average of five applicator placements per course (range 0-5). Thirty four percent reported using general anesthesia alone (GA) for intracavitary BT (n=41), 20% conscious sedation (CS) alone, 10% oral analgesia (OA) alone, and 9% spinal or epidural AS alone. The remaining responses were combinations of AG or AS (see table 1). Hybrid intracavitary/interstitial BT applicators are being used by 61% of respondents, 49% of which are vendor made devices (e.g., Elekta/Varian). Among those performing hybrid BT (n=25), 40% use GA alone, 16% use CS alone, 12% epidural or spinal AS alone, and 4% OA alone. The remaining responses were combinations of AG or AS. For template interstitial BT (n=25), 44% use GA alone, 48% epidural alone or in combination with other AS, and 8% CS alone. Twenty-two percent of all respondents report providing AG or AS during applicator placement only, while 32% report offering it during placement, planning, treatment, and removal. The most commonly cited reason for not using CS or GA was lack of anesthesia resources and clinician preference. Seventy-three percent reported the belief that patients suffer from post-traumatic stress disorder (PTSD) symptoms after BT. However, 68% reported not using techniques to help alleviate emotional distress related to BT procedures.</div></div><div><h3>Conclusions</h3><div>AG/AS practice patterns for gynecologic BT vary widely across the United States. While many clinicians report using some form of GA, CS or epidural AS, 10% are using only oral analgesia methods, and 22% are offering AG/AS only during applicator placement.
{"title":"Thursday, July 11, 20245:00 PM - 6:00 PM GSOR01 Presentation Time: 5:00 PM","authors":"Dulce M. Barrios MD , Mitchell Kamrava MD , Jenna M. Kahn MD , Vonetta M. Williams MD , Keyur J. Mehta MD , Aaron Wolfson MD , Lorraine Portelance MD , Amanda Rivera MD","doi":"10.1016/j.brachy.2024.08.047","DOIUrl":"10.1016/j.brachy.2024.08.047","url":null,"abstract":"<div><h3>Purpose</h3><div>To determine the current practice patterns of analgesia (AG) and anesthesia (AS) use across the U.S. for gynecologic brachytherapy (BT) procedures.</div></div><div><h3>Methods and Materials</h3><div>A 27-item survey was created with expertise from five practicing radiation oncology brachytherapists in the U.S. and distributed electronically to 90 Radiation Oncology residency programs for dissemination. The survey was also publicized on social media via the X (formally Twitter) platform, and at two national meetings (The American Brachytherapy Society Annual Meeting 2023 and The American Society for Radiation Therapy Annual Meeting 2023) during the months of June-October 2023.</div></div><div><h3>Results</h3><div>Forty-one responses were received (46% response rate). Fifty-four percent identified as female, 66% Caucasian race and 85% of non-Hispanic/Latino ethnicity. Ninety-three percent were physician brachytherapists, 5% medical physicists, and 2% did not disclose their profession. Forty nine percent reported typically carrying out procedures in a BT suite ± separate CT simulator alone, 39% in the operating room ± BT suite or CT simulator or other location. Ten percent reported the CT simulation room alone, and 2% in a clinic exam room. The number of cervix BT courses most frequently performed per month was between 0 and 5 at 61%, and 44% reported an average of five applicator placements per course (range 0-5). Thirty four percent reported using general anesthesia alone (GA) for intracavitary BT (n=41), 20% conscious sedation (CS) alone, 10% oral analgesia (OA) alone, and 9% spinal or epidural AS alone. The remaining responses were combinations of AG or AS (see table 1). Hybrid intracavitary/interstitial BT applicators are being used by 61% of respondents, 49% of which are vendor made devices (e.g., Elekta/Varian). Among those performing hybrid BT (n=25), 40% use GA alone, 16% use CS alone, 12% epidural or spinal AS alone, and 4% OA alone. The remaining responses were combinations of AG or AS. For template interstitial BT (n=25), 44% use GA alone, 48% epidural alone or in combination with other AS, and 8% CS alone. Twenty-two percent of all respondents report providing AG or AS during applicator placement only, while 32% report offering it during placement, planning, treatment, and removal. The most commonly cited reason for not using CS or GA was lack of anesthesia resources and clinician preference. Seventy-three percent reported the belief that patients suffer from post-traumatic stress disorder (PTSD) symptoms after BT. However, 68% reported not using techniques to help alleviate emotional distress related to BT procedures.</div></div><div><h3>Conclusions</h3><div>AG/AS practice patterns for gynecologic BT vary widely across the United States. While many clinicians report using some form of GA, CS or epidural AS, 10% are using only oral analgesia methods, and 22% are offering AG/AS only during applicator placement. ","PeriodicalId":55334,"journal":{"name":"Brachytherapy","volume":"23 6","pages":"Pages S41-S42"},"PeriodicalIF":1.7,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-25DOI: 10.1016/j.brachy.2024.08.080
Sharbacha Edward PhD in Medical Physics, Justin Mikell PhD, Jose Garcia-Ramirez MS, Michael B. Altman PhD, Phillip D. Wall PhD, Anamaria Guta MS, Jason LaBrash BS, Jessika A. Contreras MD, Jacqueline E. Zoberi PhD
<div><h3>Purpose</h3><div>Two high dose rate (HDR) remote afterloaders (RALs) were recently accepted and commissioned for use in our clinic. These RALs are unique in that prior to treatment, they measure each connected applicator + transfer guide tube (TGT) channel length with the dummy wire. If this measurement deviation is within some user-specified tolerance, the RAL automatically adjusts the planned channel length (and subsequent dwell positions) used for treatment by the active wire. This work evaluates the positional accuracy of these units and reports their performance over the first few months of gynecologic patient treatments.</div></div><div><h3>Materials and Methods</h3><div>Acceptance testing and commissioning were performed for both units: RAL1 in August 2023, and RAL2 in November 2023. Applicator + TGT channel length verification tests were performed as part of this process. Channel lengths were measured with two independent ruler systems provided by the manufacturer. Manually measured channel lengths were within 0.5 mm of the baseline nominal values provided by the manufacturer. In order to quantify RAL positional accuracy, rigid fixed length applicators - including tandems, ovoids, cylinders, and Simon-Heyman capsules - were affixed to radiochromic film, and double exposure irradiations were performed. First, they were irradiated using a mobile C-Arm fluoroscopy unit. An autoradiograph was then acquired using mock treatment plans designed using nominal channel lengths as the planned lengths, and delivered by the RALs using an ideal applicator setup, i.e. minimizing curvature of TGTs. We configured the RAL to automatically adjust dwell positions when the difference between the RAL-measured and planned channel lengths were within 2 mm. Dwell position deviations measured on film were compared with differences between planned and RAL-measured channel lengths. The record and verify system's treatment summary was queried to extract the RALs’ measured channel lengths. The performance of each RAL was assessed over time by comparing the treatment summary channel lengths for patient treatments with the planned values.</div></div><div><h3>Results</h3><div>Double exposure films indicated that, on average, dwell positions deviated towards the applicator tip by 0.8mm (max=1.5mm). Mean difference between planned and RAL-measured channel lengths was 0.5 mm (max=0.9mm). On both RALs, more curved applicators had larger length deviations during commissioning and patient treatments. This increased curvature resulted in larger overestimates of channel length, up to 1.7mm for ovoids. Ovoid channel length deviations were similar for left and right ovoids on RAL1 at just over 1mm initially, and decreased over a 23 week period to be <1mm. The deviations however remained steady for RAL2 over 10 weeks of treatment, with 90% of all values being >1mm(Fig.1). Left ovoids showed larger deviation than right (1.45 vs 1.18mm respectively) (p<0.01).</div><
{"title":"PHSOR06 Presentation Time: 9:25 AM","authors":"Sharbacha Edward PhD in Medical Physics, Justin Mikell PhD, Jose Garcia-Ramirez MS, Michael B. Altman PhD, Phillip D. Wall PhD, Anamaria Guta MS, Jason LaBrash BS, Jessika A. Contreras MD, Jacqueline E. Zoberi PhD","doi":"10.1016/j.brachy.2024.08.080","DOIUrl":"10.1016/j.brachy.2024.08.080","url":null,"abstract":"<div><h3>Purpose</h3><div>Two high dose rate (HDR) remote afterloaders (RALs) were recently accepted and commissioned for use in our clinic. These RALs are unique in that prior to treatment, they measure each connected applicator + transfer guide tube (TGT) channel length with the dummy wire. If this measurement deviation is within some user-specified tolerance, the RAL automatically adjusts the planned channel length (and subsequent dwell positions) used for treatment by the active wire. This work evaluates the positional accuracy of these units and reports their performance over the first few months of gynecologic patient treatments.</div></div><div><h3>Materials and Methods</h3><div>Acceptance testing and commissioning were performed for both units: RAL1 in August 2023, and RAL2 in November 2023. Applicator + TGT channel length verification tests were performed as part of this process. Channel lengths were measured with two independent ruler systems provided by the manufacturer. Manually measured channel lengths were within 0.5 mm of the baseline nominal values provided by the manufacturer. In order to quantify RAL positional accuracy, rigid fixed length applicators - including tandems, ovoids, cylinders, and Simon-Heyman capsules - were affixed to radiochromic film, and double exposure irradiations were performed. First, they were irradiated using a mobile C-Arm fluoroscopy unit. An autoradiograph was then acquired using mock treatment plans designed using nominal channel lengths as the planned lengths, and delivered by the RALs using an ideal applicator setup, i.e. minimizing curvature of TGTs. We configured the RAL to automatically adjust dwell positions when the difference between the RAL-measured and planned channel lengths were within 2 mm. Dwell position deviations measured on film were compared with differences between planned and RAL-measured channel lengths. The record and verify system's treatment summary was queried to extract the RALs’ measured channel lengths. The performance of each RAL was assessed over time by comparing the treatment summary channel lengths for patient treatments with the planned values.</div></div><div><h3>Results</h3><div>Double exposure films indicated that, on average, dwell positions deviated towards the applicator tip by 0.8mm (max=1.5mm). Mean difference between planned and RAL-measured channel lengths was 0.5 mm (max=0.9mm). On both RALs, more curved applicators had larger length deviations during commissioning and patient treatments. This increased curvature resulted in larger overestimates of channel length, up to 1.7mm for ovoids. Ovoid channel length deviations were similar for left and right ovoids on RAL1 at just over 1mm initially, and decreased over a 23 week period to be <1mm. The deviations however remained steady for RAL2 over 10 weeks of treatment, with 90% of all values being >1mm(Fig.1). Left ovoids showed larger deviation than right (1.45 vs 1.18mm respectively) (p<0.01).</div><","PeriodicalId":55334,"journal":{"name":"Brachytherapy","volume":"23 6","pages":"Pages S60-S61"},"PeriodicalIF":1.7,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142527205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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