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Benchmark Dose Assessment for Coke Oven Emissions-Induced Mitochondrial DNA Copy Number Damage Effects* 焦炉排放诱导线粒体DNA拷贝数损伤效应的基准剂量评估*
3区 医学 Q2 ENVIRONMENTAL SCIENCES
Biomedical and Environmental Sciences
Pub Date : 2023-06-01 DOI: 10.3967/bes2023.060
YAN Zhao Fan , GU Zhi Guang , FAN Ya Hui , LI Xin Ling , NIU Ze Ming , DUAN Xiao Ran , Mallah Ali Manthar , ZHANG Qiao , YANG Yong Li , YAO Wu , WANG Wei

Objective

The study aimed to estimate the benchmark dose (BMD) of coke oven emissions (COEs) exposure based on mitochondrial damage with the mitochondrial DNA copy number (mtDNAcn) as a biomarker.

Methods

A total of 782 subjects were recruited, including 238 controls and 544 exposed workers. The mtDNAcn of peripheral leukocytes was detected through the real-time fluorescence-based quantitative polymerase chain reaction. Three BMD approaches were used to calculate the BMD of COEs exposure based on the mitochondrial damage and its 95% confidence lower limit (BMDL).

Results

The mtDNAcn of the exposure group was lower than that of the control group (0.60 ± 0.29 vs. 1.03 ± 0.31; P < 0.001). A dose–response relationship was shown between the mtDNAcn damage and COEs. Using the Benchmark Dose Software, the occupational exposure limits (OELs) for COEs exposure in males was 0.00190 mg/m3. The OELs for COEs exposure using the BBMD were 0.00170 mg/m3 for the total population, 0.00158 mg/m3 for males, and 0.00174 mg/m3 for females. In possible risk obtained from animal studies (PROAST), the OELs of the total population, males, and females were 0.00184, 0.00178, and 0.00192 mg/m3 respectively.

Conclusion

Based on our conservative estimate, the BMDL of mitochondrial damage caused by COEs is 0.002 mg/m3. This value will provide a benchmark for determining possible OELs.

目的本研究旨在以线粒体DNA拷贝数（mtDNAcn）为生物标志物，基于线粒体损伤来估计焦炉排放物（COEs）暴露的基准剂量（BMD）。方法共招募782名受试者，包括238名对照和544名暴露工人。采用实时荧光定量聚合酶链反应检测外周血白细胞mtDNAcn。基于线粒体损伤及其95%置信下限（BMDL），采用三种BMD方法计算COEs暴露的BMD。结果暴露组的mtDNAcn低于对照组（0.60±0.29 vs.1.03±0.31；P<；0.001）。使用基准剂量软件，男性COE暴露的职业暴露限值（OEL）为0.00190 mg/m3。使用BBMD的COE暴露的OEL为0.00170 mg/m3（总人群）、0.00158 mg/m3（男性）和0.00174 mg/m3（女性）。在动物研究（PROAST）获得的可能风险中，总人群、雄性和雌性的OEL分别为0.00184、0.00178和0.00192 mg/m3。结论根据我们的保守估计，COEs引起的线粒体损伤的BMDL为0.002mg/m3。该值将为确定可能的OEL提供基准。
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引用次数: 0
Improved Specificity for Breast Cancer Screening Using an Oncogenic (miRNA-21) and a Gene Suppressor (miRNA-195) miRNA in the Serum for a Point of Care (POC) Screening Solution 在用于护理点（POC）筛查溶液的血清中使用癌原性（miRNA-21）和基因抑制因子（miRNA-195）miRNA提高癌症筛查的特异性
3区 医学 Q2 ENVIRONMENTAL SCIENCES
Biomedical and Environmental Sciences
Pub Date : 2023-06-01 DOI: 10.3967/bes2023.067
Krishnamoorthy Kokilavani , Ancy Terryna Chanayiltharayil John , Bindu Salim , Madhulika Vijayakumar , Sankar Ganesh Jeyaraj
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引用次数: 0
Trends of Oral Cancer Mortality in China from 1990 to 2019 and a 15-Year Predictive Analysis Based on a Bayesian Age-Period-Cohort Model* 1990～2019年中国口腔癌症死亡率趋势及基于Bayesian Age-Period-Coort模型的15年预测分析*
3区 医学 Q2 ENVIRONMENTAL SCIENCES
Biomedical and Environmental Sciences
Pub Date : 2023-06-01 DOI: 10.3967/bes2023.068
GU Jian Chang , SONG Ji Wu , LIU Yun , WANG Xiao Lan , XU Shuang Shuang , ZHANG Liang Liang , LIU Yun Xia , DING Gang
{"title":"Trends of Oral Cancer Mortality in China from 1990 to 2019 and a 15-Year Predictive Analysis Based on a Bayesian Age-Period-Cohort Model*","authors":"GU Jian Chang ,&nbsp;SONG Ji Wu ,&nbsp;LIU Yun ,&nbsp;WANG Xiao Lan ,&nbsp;XU Shuang Shuang ,&nbsp;ZHANG Liang Liang ,&nbsp;LIU Yun Xia ,&nbsp;DING Gang","doi":"10.3967/bes2023.068","DOIUrl":"10.3967/bes2023.068","url":null,"abstract":"","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 6","pages":"Pages 553-556"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9809084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cost-Effectiveness Analysis of Combined Chemotherapy Regimen Containing Bedaquiline in the Treatment of Multidrug-Resistant Tuberculosis in China* 国产贝达奎林联合化疗方案治疗耐多药结核病的成本-效果分析*
3区 医学 Q2 ENVIRONMENTAL SCIENCES
Biomedical and Environmental Sciences
Pub Date : 2023-06-01 DOI: 10.3967/bes2023.061
XU Cai Hong , QIU Ying Peng , HE Zi Long , HU Dong Mei , YUE Xiao , CHEN Zhong Dan , XU Yuan Yuan , ZHAO Yan Lin

Objective

This study aims to estimate the cost-effectiveness of the combined chemotherapy regimen containing Bedaquiline (BR) and the conventional treatment regimen (CR, not containing Bedaquiline) for the treatment of adults with multidrug-resistant tuberculosis (MDR-TB) in China.

Methods

A combination of a decision tree and a Markov model was developed to estimate the cost and effects of MDR patients in BR and CR within ten years. The model parameter data were synthesized from the literature, the national TB surveillance information system, and consultation with experts. The incremental cost-effectiveness ratio (ICER) of BR vs. CR was determined.

Results

BR (vs. CR) had a higher sputum culture conversion rate and cure rate and prevented many premature deaths (decreased by 12.8%), thereby obtaining more quality-adjusted life years (QALYs) (increased by 2.31 years). The per capita cost in BR was as high as 138,000 yuan, roughly double that of CR. The ICER for BR was 33,700 yuan/QALY, which was lower than China’s 1× per capita Gross Domestic Product (GDP) in 2020 (72,400 yuan).

Conclusion

BR is shown to be cost effective. When the unit price of Bedaquiline reaches or falls below 57.21 yuan per unit, BR is expected to be the dominant strategy in China over CR.

目的本研究旨在评估含贝达奎林（BR）和常规治疗方案（CR，不含贝达奎林）联合化疗方案治疗中国成人耐多药结核病（MDR-TB）的成本效益BR和CR患者在10年内。模型参数数据来自文献、国家结核病监测信息系统和专家咨询。测定BR与CR的增量成本效益比（ICER）。结果BR（与CR相比）具有更高的痰培养转化率和治愈率，并预防了许多过早死亡（减少了12.8%），从而获得了更多的质量调整生命年（增加了2.31年）。BR的人均成本高达13.8万元，大约是CR的两倍。BR的ICER为3.37万元/QALY，低于中国2020年的1×人均国内生产总值（GDP）（7.24万元）。结论BR具有成本效益。当Bedaquiline的单价达到或低于57.21元/台时，BR有望成为中国市场上优于CR的主导策略。
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引用次数: 0
Diagnostic Efficacy of 18F-FDG PET/CT in Detecting Bone Marrow Infiltration in Patients with Newly Diagnosed Diffuse Large B-Cell Lymphoma* 18F-FDG PET/CT对新诊断弥漫性大b细胞淋巴瘤骨髓浸润的诊断价值*
IF 3.5 3区 医学 Q2 ENVIRONMENTAL SCIENCES
Biomedical and Environmental Sciences
Pub Date : 2023-06-01 DOI: 10.3967/bes2023.062
GUO Bo , QIN Ran , GU Zhen Yang , LI Yan Fen , GAO Lei , HUANG Wen Rong

Objective

Diffuse large B-cell lymphoma (DLBCL) is often associated with bone marrow infiltration, and 2-deoxy-2-(18F) fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) has potential diagnostic significance for bone marrow infiltration in DLBCL.

Methods

A total of 102 patients diagnosed with DLBCL between September 2019 and August 2022 were included. Bone marrow biopsy and 18F-FDG PET/CT examinations were performed at the time of initial diagnosis. Kappa tests were used to evaluate the agreement of 18F-FDG PET/CT with the gold standard, and the imaging features of DLBCL bone marrow infiltration on PET/CT were described.

Results

The total detection rate of bone marrow infiltration was not significantly different between PET/CT and primary bone marrow biopsy (P = 0.302) or between the two bone marrow biopsies (P = 0.826). The sensitivity, specificity, and Youden index of PET/CT for the diagnosis of DLBCL bone marrow infiltration were 0.923 (95% CI, 0.759–0.979), 0.934 (95% CI, 0.855–0.972), and 0.857, respectively.

Conclusion

18F-FDG PET/CT has a comparable efficiency in the diagnosis of DLBCL bone marrow infiltration. PET/CT-guided bone marrow biopsy can reduce the misdiagnosis of DLBCL bone marrow infiltration.

目的弥漫性大B细胞淋巴瘤（DLBCL）通常与骨髓浸润有关，2-脱氧-2-（18F）氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（18F-FDG PET/CT）对DLBCL的骨髓浸润具有潜在的诊断意义。在最初诊断时进行骨髓活检和18F-FDG PET/CT检查。用Kappa试验评价18F-FDG PET/CT与金标准的一致性，并描述了DLBCL骨髓浸润在PET/CT上的成像特征。结果PET/CT对DLBCL骨髓浸润的诊断敏感性、特异性和Youden指数分别为0.923（95%CI，0.759–0.979）、0.934（95%CI，0.855–0.972）和0.857，分别地结论18F-FDGPET/CT对DLBCL骨髓浸润的诊断具有可比性。PET/CT引导下骨髓活检可减少DLBCL骨髓浸润的误诊。
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引用次数: 0
Diagnostic Efficacy of 18F-FDG PET/CT in Detecting Bone Marrow Infiltration in Patients with Newly Diagnosed Diffuse Large B-Cell Lymphoma* 18F-FDG PET/CT对新诊断弥漫性大B细胞淋巴瘤骨髓浸润的诊断价值*
3区 医学 Q2 ENVIRONMENTAL SCIENCES
Biomedical and Environmental Sciences
Pub Date : 2023-06-01 DOI: 10.3967/bes2023.062
GUO Bo , QIN Ran , GU Zhen Yang , LI Yan Fen , GAO Lei , HUANG Wen Rong

Objective

Diffuse large B-cell lymphoma (DLBCL) is often associated with bone marrow infiltration, and 2-deoxy-2-(18F) fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) has potential diagnostic significance for bone marrow infiltration in DLBCL.

Methods

A total of 102 patients diagnosed with DLBCL between September 2019 and August 2022 were included. Bone marrow biopsy and 18F-FDG PET/CT examinations were performed at the time of initial diagnosis. Kappa tests were used to evaluate the agreement of 18F-FDG PET/CT with the gold standard, and the imaging features of DLBCL bone marrow infiltration on PET/CT were described.

Results

The total detection rate of bone marrow infiltration was not significantly different between PET/CT and primary bone marrow biopsy (P = 0.302) or between the two bone marrow biopsies (P = 0.826). The sensitivity, specificity, and Youden index of PET/CT for the diagnosis of DLBCL bone marrow infiltration were 0.923 (95% CI, 0.759–0.979), 0.934 (95% CI, 0.855–0.972), and 0.857, respectively.

Conclusion

18F-FDG PET/CT has a comparable efficiency in the diagnosis of DLBCL bone marrow infiltration. PET/CT-guided bone marrow biopsy can reduce the misdiagnosis of DLBCL bone marrow infiltration.

目的弥漫性大B细胞淋巴瘤（DLBCL）通常与骨髓浸润有关，2-脱氧-2-（18F）氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（18F-FDG PET/CT）对DLBCL的骨髓浸润具有潜在的诊断意义。在最初诊断时进行骨髓活检和18F-FDG PET/CT检查。用Kappa试验评价18F-FDG PET/CT与金标准的一致性，并描述了DLBCL骨髓浸润在PET/CT上的成像特征。结果PET/CT对DLBCL骨髓浸润的诊断敏感性、特异性和Youden指数分别为0.923（95%CI，0.759–0.979）、0.934（95%CI，0.855–0.972）和0.857，分别地结论18F-FDGPET/CT对DLBCL骨髓浸润的诊断具有可比性。PET/CT引导下骨髓活检可减少DLBCL骨髓浸润的误诊。
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引用次数: 0
Contribution of Ambient Air Pollution on Risk Assessment of Type 2 Diabetes Mellitus via Explainable Machine Learning* 环境空气污染对2型糖尿病风险评估的贡献——基于可解释机器学习*
3区 医学 Q2 ENVIRONMENTAL SCIENCES
Biomedical and Environmental Sciences
Pub Date : 2023-06-01 DOI: 10.3967/bes2023.069
DING Zhong Ao , ZHANG Li Ying , LI Rui Ying , NIU Miao Miao , ZHAO Bo , DONG Xiao Kang , LIU Xiao Tian , HOU Jian , MAO Zhen Xing , WANG Chong Jian
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引用次数: 0
A Rapid and Accurate CRISPR/Cas12b-Mediated Genotyping Assay for the Methylenetetrahydrofolate Reductase Gene Polymorphism C677T* 一种快速准确的CRISPR/Cas12b介导的亚甲基四氢叶酸还原酶基因C677T多态性基因分型方法*
3区 医学 Q2 ENVIRONMENTAL SCIENCES
Biomedical and Environmental Sciences
Pub Date : 2023-06-01 DOI: 10.3967/bes2023.070
SI Xin Xin , ZHANG Quan , LUO Zhi Dan , ZHANG Zhen Yu , WANG Yan , SHAO Li Pei
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引用次数: 0
Differences in Pandemic-Related Factors Associated with Alcohol and Substance Use among Korean Adolescents: Nationwide Representative Study* 韩国青少年与酒精和药物使用相关的流行病相关因素的差异：全国代表性研究*
3区 医学 Q2 ENVIRONMENTAL SCIENCES
Biomedical and Environmental Sciences
Pub Date : 2023-06-01 DOI: 10.3967/bes2023.066
Hyunju Yon , Sangil Park , Jung U Shin , Ai Koyanagi , Louis Jacob , Lee Smith , Chanyang Min , Jinseok Lee , Rosie Kwon , Guillaume Fond , Laurent Boyer , Sunyoung Kim , Namwoo Kim , Sang Youl Rhee , Jae Il Shin , Dong Keon Yon , Ho Geol Woo
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引用次数: 1
Clinical Evaluation of a Vancomycin Dosage Strategy Based on a Serum Trough Concentration Model in Elderly Patients with Severe Pneumonia 基于血清谷浓度模型的老年重症肺炎万古霉素剂量策略的临床评价
3区 医学 Q2 ENVIRONMENTAL SCIENCES
Biomedical and Environmental Sciences
Pub Date : 2023-05-01 DOI: 10.3967/bes2023.049
YAN Wei , SUN Xiao Yan , WANG Meng, ZHAO Fei Fan, ZHOU Qing Tao

Objective

This study aimed to evaluate the clinical benefits of a vancomycin dosage strategy based on a serum trough concentration model in elderly patients.

Methods

This prospective single-center, open-label, randomized controlled trial categorized 66 elderly patients with severe pneumonia into study and control groups. The control group received vancomycin using a regimen decided by the attending physician. Meanwhile, the study group received individualized vancomycin therapy with a dosing strategy based on a serum trough concentration model. The primary endpoint was the proportion of patients with serum trough concentrations reaching the target values. The secondary endpoints were clinical response, vancomycin treatment duration, and vancomycin-associated acute kidney injury (VA-AKI) occurrence.

Results

All patients were at least 60 years old (median age = 81 years). The proportion of patients with target trough concentration achievement (≥ 15 mg/L) with the initial vancomycin regimen was significantly higher in the study group compared to the control group (75.8% vs. 42.4%, P = 0.006). Forty-five patients (68.2%) achieved clinical success, the median duration of vancomycin therapy was 10.0 days, and VA-AKI occurred in eight patients (12.1%). However, there were no significant differences in these parameters between the two groups. The model for predicting vancomycin trough concentrations was upgraded to: serum trough concentration (mg/L) = 17.194 − 0.104 × creatinine clearance rate (mL/min) + 0.313 × vancomycin daily dose [(mg/(kg·d)].

Conclusion

A vancomycin dosage strategy based on a serum trough concentration model can improve the proportion of patients achieving target trough concentrations in elderly patients with severe pneumonia.

目的本研究旨在评估基于血清谷浓度模型的万古霉素剂量策略对老年患者的临床益处。方法本前瞻性单中心、开放标签、随机对照试验将66例老年重症肺炎患者分为研究组和对照组。对照组采用主治医师决定的方案接受万古霉素治疗。同时，研究组接受了基于血清谷浓度模型的个体化万古霉素治疗。主要终点是血清谷浓度达到目标值的患者比例。次要终点是临床反应、万古霉素治疗持续时间和万古霉素相关急性肾损伤（VA-AKI）的发生率。结果所有患者年龄均在60岁以上（中位年龄=81岁）。与对照组相比，研究组首次万古霉素方案达到目标谷浓度（≥15 mg/L）的患者比例显著更高（75.8%对42.4%，P=0.006）。45名患者（68.2%）取得了临床成功，万古霉素治疗的中位持续时间为10.0天，8名患者（12.1%）发生VA-AKI。然而，两组之间的这些参数没有显著差异。预测万古霉素谷浓度的模型升级为：血清谷浓度（mg/L）=17.194−0.104×肌酐清除率（mL/min）+0.313×万古霉素日剂量[（mg/（kg·d）]严重肺炎。
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引用次数: 0
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