{"title":"Impact of the Early Stage of the COVID-19 Pandemic on Smoking Cessation in Beijing","authors":"WANG Yao, LI Xing Ming","doi":"10.3967/bes2023.054","DOIUrl":"10.3967/bes2023.054","url":null,"abstract":"","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 5","pages":"Pages 452-457"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10240790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9581605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
WANG Bi Yan , SONG Man Shu , ZHANG Jie , MENG Xiao Ni , XING Wei Jia , WANG You Xin
Objective
This study prospectively investigates the association between immunoglobulin G (IgG) N-glycan traits and ischemic stroke (IS) risk.
Methods
A nested case-control study was conducted in the China suboptimal health cohort study, which recruited 4,313 individuals in 2013–2014. Cases were identified as patients diagnosed with IS, and controls were 1:1 matched by age and sex with cases. IgG N-glycans in baseline plasma samples were analyzed.
Results
A total of 99 IS cases and 99 controls were included, and 24 directly measured glycan peaks (GPs) were separated from IgG N-glycans. In directly measured GPs, GP4, GP9, GP21, GP22, GP23, and GP24 were associated with the risk of IS in men after adjusting for age, waist and hip circumference, obesity, diabetes, hypertension, and dyslipidemia. Derived glycan traits representing decreased galactosylation and sialylation were associated with IS in men (FBG2S2/(FBG2 + FBG2S1 + FBG2S2): odds ratio (OR) = 0.92, 95% confidence interval (CI): 0.87–0.97; G1n: OR = 0.74, 95% CI: 0.63–0.87; G0n: OR = 1.12, 95% CI: 1.03–1.22). However, these associations were not found among women.
Conclusion
This study validated that altered IgG N-glycan traits were associated with incident IS in men, suggesting that sex discrepancies might exist in these associations.
{"title":"A Nested Case-Control Study to Explore the Association between Immunoglobulin G N-glycans and Ischemic Stroke","authors":"WANG Bi Yan , SONG Man Shu , ZHANG Jie , MENG Xiao Ni , XING Wei Jia , WANG You Xin","doi":"10.3967/bes2023.048","DOIUrl":"10.3967/bes2023.048","url":null,"abstract":"<div><h3>Objective</h3><p>This study prospectively investigates the association between immunoglobulin G (IgG) N-glycan traits and ischemic stroke (IS) risk.</p></div><div><h3>Methods</h3><p>A nested case-control study was conducted in the China suboptimal health cohort study, which recruited 4,313 individuals in 2013–2014. Cases were identified as patients diagnosed with IS, and controls were 1:1 matched by age and sex with cases. IgG N-glycans in baseline plasma samples were analyzed.</p></div><div><h3>Results</h3><p>A total of 99 IS cases and 99 controls were included, and 24 directly measured glycan peaks (GPs) were separated from IgG N-glycans. In directly measured GPs, GP4, GP9, GP21, GP22, GP23, and GP24 were associated with the risk of IS in men after adjusting for age, waist and hip circumference, obesity, diabetes, hypertension, and dyslipidemia. Derived glycan traits representing decreased galactosylation and sialylation were associated with IS in men (FBG2S2/(FBG2 + FBG2S1 + FBG2S2): odds ratio (<em>OR</em>) = 0.92, 95% confidence interval (<em>CI</em>): 0.87–0.97; G1<sup>n</sup>: <em>OR</em> = 0.74, 95% <em>CI</em>: 0.63–0.87; G0<sup>n</sup>: <em>OR</em> = 1.12, 95% <em>CI</em>: 1.03–1.22). However, these associations were not found among women.</p></div><div><h3>Conclusion</h3><p>This study validated that altered IgG N-glycan traits were associated with incident IS in men, suggesting that sex discrepancies might exist in these associations.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 5","pages":"Pages 389-396"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9552731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CEN Ping , LIANG Hua Yue , YANG Yuan , ZHANG Fei , YANG Shi Xiong , MO Ju Cong , FENG Yi , HUANG Jie Gang , NING Chuan Yi , HUANG Chun Yuan , YANG Yao , LIANG Na , LIANG Bing Yu , YE Li , LIANG Hao
Objective
The mode of human immunodeficiency virus (HIV) transmission via injection drug use (IDU) still exists, and the recent shift in IDU-related transmission of HIV infection is largely unknown. The purpose of this study was to analyze the spatiotemporal sources and dynamics of HIV-1 transmission through IDU in Guangxi.
Methods
We performed a molecular epidemiological investigation of infections across Guangxi from 2009 to 2019. Phylogenetic and Bayesian time-geographic analyses of HIV-1 sequences were performed to confirm the characteristics of transmission between IDUs in combination with epidemiological data.
Results
Among the 535 subjects, CRF08_BC (57.4%), CRF01_AE (28.4%), and CRF07_BC (10.7%) were the top 3 HIV strains; 72.6% of infections were linked to other provinces in the transmission network; 93.6% of sequence-transmitted strains were locally endemic, with the rest coming from other provinces, predominantly Guangdong and Yunnan; 92.1% of the HIV transmission among people who inject drugs tended to be transmitted between HIV-positive IDUs.
Conclusion
HIV recombinants were high diversity, and circulating local strains were the transmission sources among IDUs in Guangxi. However, there were still cases of IDUs linked to other provinces. Coverage of traditional prevention strategies should be expanded, and inter-provincial collaboration between Guangxi, Yunnan, and Guangdong provinces should be strengthened.
{"title":"HIV-1 Transmission among Injecting Drug Users is Principally Derived from Local Circulating Strains in Guangxi, China","authors":"CEN Ping , LIANG Hua Yue , YANG Yuan , ZHANG Fei , YANG Shi Xiong , MO Ju Cong , FENG Yi , HUANG Jie Gang , NING Chuan Yi , HUANG Chun Yuan , YANG Yao , LIANG Na , LIANG Bing Yu , YE Li , LIANG Hao","doi":"10.3967/bes2023.051","DOIUrl":"10.3967/bes2023.051","url":null,"abstract":"<div><h3>Objective</h3><p>The mode of human immunodeficiency virus (HIV) transmission <em>via</em> injection drug use (IDU) still exists, and the recent shift in IDU-related transmission of HIV infection is largely unknown. The purpose of this study was to analyze the spatiotemporal sources and dynamics of HIV-1 transmission through IDU in Guangxi.</p></div><div><h3>Methods</h3><p>We performed a molecular epidemiological investigation of infections across Guangxi from 2009 to 2019. Phylogenetic and Bayesian time-geographic analyses of HIV-1 sequences were performed to confirm the characteristics of transmission between IDUs in combination with epidemiological data.</p></div><div><h3>Results</h3><p>Among the 535 subjects, CRF08_BC (57.4%), CRF01_AE (28.4%), and CRF07_BC (10.7%) were the top 3 HIV strains; 72.6% of infections were linked to other provinces in the transmission network; 93.6% of sequence-transmitted strains were locally endemic, with the rest coming from other provinces, predominantly Guangdong and Yunnan; 92.1% of the HIV transmission among people who inject drugs tended to be transmitted between HIV-positive IDUs.</p></div><div><h3>Conclusion</h3><p>HIV recombinants were high diversity, and circulating local strains were the transmission sources among IDUs in Guangxi. However, there were still cases of IDUs linked to other provinces. Coverage of traditional prevention strategies should be expanded, and inter-provincial collaboration between Guangxi, Yunnan, and Guangdong provinces should be strengthened.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 5","pages":"Pages 418-430"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9552732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ZHAO Qi , MAI Si Wei , LI Qian , HUANG Guan Chong , GAO Ming Chen , YANG Wen Li , WANG Ge , MA Ya , LI Lei , PENG Xiao Yan
Objective
To develop a few-shot learning (FSL) approach for classifying optical coherence tomography (OCT) images in patients with inherited retinal disorders (IRDs).
Methods
In this study, an FSL model based on a student–teacher learning framework was designed to classify images. 2,317 images from 189 participants were included. Of these, 1,126 images revealed IRDs, 533 were normal samples, and 658 were control samples.
Results
The FSL model achieved a total accuracy of 0.974–0.983, total sensitivity of 0.934–0.957, total specificity of 0.984–0.990, and total F1 score of 0.935–0.957, which were superior to the total accuracy of the baseline model of 0.943–0.954, total sensitivity of 0.866–0.886, total specificity of 0.962–0.971, and total F1 score of 0.859–0.885. The performance of most subclassifications also exhibited advantages. Moreover, the FSL model had a higher area under curves (AUC) of the receiver operating characteristic (ROC) curves in most subclassifications.
Conclusion
This study demonstrates the effective use of the FSL model for the classification of OCT images from patients with IRDs, normal, and control participants with a smaller volume of data. The general principle and similar network architectures can also be applied to other retinal diseases with a low prevalence.
{"title":"Automated Classification of Inherited Retinal Diseases in Optical Coherence Tomography Images Using Few-shot Learning","authors":"ZHAO Qi , MAI Si Wei , LI Qian , HUANG Guan Chong , GAO Ming Chen , YANG Wen Li , WANG Ge , MA Ya , LI Lei , PENG Xiao Yan","doi":"10.3967/bes2023.052","DOIUrl":"10.3967/bes2023.052","url":null,"abstract":"<div><h3>Objective</h3><p>To develop a few-shot learning (FSL) approach for classifying optical coherence tomography (OCT) images in patients with inherited retinal disorders (IRDs).</p></div><div><h3>Methods</h3><p>In this study, an FSL model based on a student–teacher learning framework was designed to classify images. 2,317 images from 189 participants were included. Of these, 1,126 images revealed IRDs, 533 were normal samples, and 658 were control samples.</p></div><div><h3>Results</h3><p>The FSL model achieved a total accuracy of 0.974–0.983, total sensitivity of 0.934–0.957, total specificity of 0.984–0.990, and total F1 score of 0.935–0.957, which were superior to the total accuracy of the baseline model of 0.943–0.954, total sensitivity of 0.866–0.886, total specificity of 0.962–0.971, and total F1 score of 0.859–0.885. The performance of most subclassifications also exhibited advantages. Moreover, the FSL model had a higher area under curves (AUC) of the receiver operating characteristic (ROC) curves in most subclassifications.</p></div><div><h3>Conclusion</h3><p>This study demonstrates the effective use of the FSL model for the classification of OCT images from patients with IRDs, normal, and control participants with a smaller volume of data. The general principle and similar network architectures can also be applied to other retinal diseases with a low prevalence.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 5","pages":"Pages 431-440"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9552730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
XU Di Hui , MA Yu Han , YU Wen , ZHOU Xue , LUO Yang , CHEN Ya Bing , HAN Xiao Dong
{"title":"Seminal Plasma Biochemical Components Mediate the Inverse Association of Microcystin Exposure with Sperm Motility: A Mediation Analysis in Chinese Men","authors":"XU Di Hui , MA Yu Han , YU Wen , ZHOU Xue , LUO Yang , CHEN Ya Bing , HAN Xiao Dong","doi":"10.3967/bes2023.056","DOIUrl":"10.3967/bes2023.056","url":null,"abstract":"","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 5","pages":"Pages 463-468"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9916360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
WANG Yu Tong , LI Xin Xin , HU Wei Jiang , WANG Dan , ZHANG Si Yu , LIU An Qi , SUN Xin , WAN Xia
{"title":"Geographic Distribution of Coal Enterprises and Workers Exposed to Coal Dust in China in 2020","authors":"WANG Yu Tong , LI Xin Xin , HU Wei Jiang , WANG Dan , ZHANG Si Yu , LIU An Qi , SUN Xin , WAN Xia","doi":"10.3967/bes2023.058","DOIUrl":"10.3967/bes2023.058","url":null,"abstract":"","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 5","pages":"Pages 476-480"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9916364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ZHANG Wei Wei , ZHU Xiao Lin , DENG Le Le , HAN Ya Jun , LI Zhuo Wei , WANG Jin Long , CHEN Yong Liang , WANG Ao Lin , TIAN Er Li , CHENG Bin , XU Lin Hua , CHEN Yi Cong , TIAN Li Li , HE Guang Xue
Objective
To explore the genotyping characteristics of human fecal Escherichia coli (E. coli) and the relationships between antibiotic resistance genes (ARGs) and multidrug resistance (MDR) of E. coli in Miyun District, Beijing, an area with high incidence of infectious diarrheal cases but no related data.
Methods
Over a period of 3 years, 94 E. coli strains were isolated from fecal samples collected from Miyun District Hospital, a surveillance hospital of the National Pathogen Identification Network. The antibiotic susceptibility of the isolates was determined by the broth microdilution method. ARGs, multilocus sequence typing (MLST), and polymorphism trees were analyzed using whole-genome sequencing data (WGS).
Results
This study revealed that 68.09% of the isolates had MDR, prevalent and distributed in different clades, with a relatively high rate and low pathogenicity. There was no difference in MDR between the diarrheal (49/70) and healthy groups (15/24).
Conclusion
We developed a random forest (RF) prediction model of TEM.1 + baeR + mphA + mphB + QnrS1 + AAC.3-IId to identify MDR status, highlighting its potential for early resistance identification. The causes of MDR are likely mobile units transmitting the ARGs. In the future, we will continue to strengthen the monitoring of ARGs and MDR, and increase the number of strains to further verify the accuracy of the MDR markers.
{"title":"Genotyping Characteristics of Human Fecal Escherichia coli and Their Association with Multidrug Resistance in Miyun District, Beijing","authors":"ZHANG Wei Wei , ZHU Xiao Lin , DENG Le Le , HAN Ya Jun , LI Zhuo Wei , WANG Jin Long , CHEN Yong Liang , WANG Ao Lin , TIAN Er Li , CHENG Bin , XU Lin Hua , CHEN Yi Cong , TIAN Li Li , HE Guang Xue","doi":"10.3967/bes2023.050","DOIUrl":"https://doi.org/10.3967/bes2023.050","url":null,"abstract":"<div><h3>Objective</h3><p>To explore the genotyping characteristics of human fecal <em>Escherichia coli</em> (<em>E. coli</em>) and the relationships between antibiotic resistance genes (ARGs) and multidrug resistance (MDR) of <em>E. coli</em> in Miyun District, Beijing, an area with high incidence of infectious diarrheal cases but no related data.</p></div><div><h3>Methods</h3><p>Over a period of 3 years, 94 <em>E. coli</em> strains were isolated from fecal samples collected from Miyun District Hospital, a surveillance hospital of the National Pathogen Identification Network. The antibiotic susceptibility of the isolates was determined by the broth microdilution method. ARGs, multilocus sequence typing (MLST), and polymorphism trees were analyzed using whole-genome sequencing data (WGS).</p></div><div><h3>Results</h3><p>This study revealed that 68.09% of the isolates had MDR, prevalent and distributed in different clades, with a relatively high rate and low pathogenicity. There was no difference in MDR between the diarrheal (49/70) and healthy groups (15/24).</p></div><div><h3>Conclusion</h3><p>We developed a random forest (RF) prediction model of <em>TEM.1 + baeR + mphA + mphB + QnrS1 + AAC.3-IId</em> to identify MDR status, highlighting its potential for early resistance identification. The causes of MDR are likely mobile units transmitting the ARGs. In the future, we will continue to strengthen the monitoring of ARGs and MDR, and increase the number of strains to further verify the accuracy of the MDR markers.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 5","pages":"Pages 406-417"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49843900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ZHU Wen Li , ZENG Hua , HUANG Dan Ping , OUYANG Wei Jun , WEI Chun Shan , TONG Guang Dong
{"title":"The Potential Impact of EIF4E3 and LARP1 on Tumor Immunity in Hepatocellular Carcinoma","authors":"ZHU Wen Li , ZENG Hua , HUANG Dan Ping , OUYANG Wei Jun , WEI Chun Shan , TONG Guang Dong","doi":"10.3967/bes2023.057","DOIUrl":"10.3967/bes2023.057","url":null,"abstract":"","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 5","pages":"Pages 469-475"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9916363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mei ZHANG , Ke PENG , Xiao ZHANG , Yi Shu LIU , Xiao Ying LIU , Gui Yuan HAN , Yu SHI , Zheng Jing HUANG , Chun LI , Zhen Ping ZHAO , Li Min WANG , Yi Chong LI
Objective
To investigate the spatial patterns of the prevalence, awareness, treatment, and control rates of dyslipidemia at the provincial level in China.
Methods
A national and provincial representative cross-sectional survey was conducted among 178,558 Chinese adults in 31 provinces in mainland China in 2018–2019, using a multi-stage, stratified, cluster-randomized sampling design. Subjects, as households, were selected, followed by a home visit to collect information. Both descriptive and linear regression procedures were applied in the analyses.
Results
The overall prevalence of dyslipidemia was 35.6%, and wide geographic variations of prevalence, treatment, and control rates of dyslipidemia were identified among 178,558 eligible participants with a mean age of 55.1 ± 13.8 years. The highest-lowest difference regarding the provincial level prevalence rates were 19.7% vs. 2.1% for high low-density lipoprotein cholesterol, 16.7% vs. 2.5% for high total cholesterol, 35.9% vs. 5.4% for high triglycerides, and 31.4% vs. 10.5% for low high-density lipoprotein cholesterol. The treatment rate of dyslipidemia was correlated with the socio-demographic index (P < 0.001), urbanization rate (P = 0.01), and affordable basic technologies and essential medicines (P < 0.001).
Conclusion
Prevailing dyslipidemia among the Chinese population and its wide geographic variations in prevalence, treatment, and control suggest that China needs both integrated and localized public health strategies across provinces to improve lipid management.
{"title":"Geographic Variations in the Prevalence, Awareness, Treatment, and Control of Dyslipidemia among Chinese Adults in 2018–2019: A Cross-sectional Study","authors":"Mei ZHANG , Ke PENG , Xiao ZHANG , Yi Shu LIU , Xiao Ying LIU , Gui Yuan HAN , Yu SHI , Zheng Jing HUANG , Chun LI , Zhen Ping ZHAO , Li Min WANG , Yi Chong LI","doi":"10.3967/bes2023.037","DOIUrl":"10.3967/bes2023.037","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the spatial patterns of the prevalence, awareness, treatment, and control rates of dyslipidemia at the provincial level in China.</p></div><div><h3>Methods</h3><p>A national and provincial representative cross-sectional survey was conducted among 178,558 Chinese adults in 31 provinces in mainland China in 2018–2019, using a multi-stage, stratified, cluster-randomized sampling design. Subjects, as households, were selected, followed by a home visit to collect information. Both descriptive and linear regression procedures were applied in the analyses.</p></div><div><h3>Results</h3><p>The overall prevalence of dyslipidemia was 35.6%, and wide geographic variations of prevalence, treatment, and control rates of dyslipidemia were identified among 178,558 eligible participants with a mean age of 55.1 ± 13.8 years. The highest-lowest difference regarding the provincial level prevalence rates were 19.7% <em>vs.</em> 2.1% for high low-density lipoprotein cholesterol, 16.7% <em>vs.</em> 2.5% for high total cholesterol, 35.9% <em>vs.</em> 5.4% for high triglycerides, and 31.4% <em>vs.</em> 10.5% for low high-density lipoprotein cholesterol. The treatment rate of dyslipidemia was correlated with the socio-demographic index (<em>P</em> < 0.001), urbanization rate (<em>P</em> = 0.01), and affordable basic technologies and essential medicines (<em>P</em> < 0.001).</p></div><div><h3>Conclusion</h3><p>Prevailing dyslipidemia among the Chinese population and its wide geographic variations in prevalence, treatment, and control suggest that China needs both integrated and localized public health strategies across provinces to improve lipid management.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 4","pages":"Pages 313-323"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9738548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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