Yu Chen JIN , Li Juan DONG , Qin Yue YANG , Wei Ning XIONG , Wei Yi WANG , Xian Hong FENG , Wei YU , Wei HUANG , Bi Feng CHEN
Objective
To investigate the effects of the B7-H4 gene rs10754339 and miR-125a gene rs12976445 on cancer susceptibility through a case-control study and meta-analysis.
Methods
A total of 1,490 cancer patients (lung/gastric/liver/: 550/460/480) and 800 controls were recruited in this case-control study. The meta-analysis was performed by pooling the data from previous related studies and the present study.
Results
The results of this study showed that in the Hubei Han Chinese population, the rs10754339 gene was significantly associated with the risk of lung and gastric cancer but not liver cancer, and the rs12976445 gene was significantly associated with the risk of lung cancer but not liver or gastric cancer. The meta-analysis results indicated that rs10754339 and rs12976445 contributed to cancer susceptibility in the Chinese population and also revealed a significant association between rs10754339 and breast cancer risk, as well as between rs12976445 and lung cancer risk.
Conclusion
The B7-H4 gene rs10754339 and miR-125a gene rs12976445 may be the potential genetic markers for cancer susceptibility in the Chinese population, which should be validated in future studies with larger sample sizes in other ethnic populations.
{"title":"An Investigation of the Effects of B7-H4 Gene rs10754339 and miR-125a Gene rs12976445 on Cancer Susceptibility","authors":"Yu Chen JIN , Li Juan DONG , Qin Yue YANG , Wei Ning XIONG , Wei Yi WANG , Xian Hong FENG , Wei YU , Wei HUANG , Bi Feng CHEN","doi":"10.3967/bes2023.074","DOIUrl":"https://doi.org/10.3967/bes2023.074","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the effects of the <em>B7-H4</em> gene rs10754339 and <em>miR-125a</em> gene rs12976445 on cancer susceptibility through a case-control study and meta-analysis.</p></div><div><h3>Methods</h3><p>A total of 1,490 cancer patients (lung/gastric/liver/: 550/460/480) and 800 controls were recruited in this case-control study. The meta-analysis was performed by pooling the data from previous related studies and the present study.</p></div><div><h3>Results</h3><p>The results of this study showed that in the Hubei Han Chinese population, the rs10754339 gene was significantly associated with the risk of lung and gastric cancer but not liver cancer, and the rs12976445 gene was significantly associated with the risk of lung cancer but not liver or gastric cancer. The meta-analysis results indicated that rs10754339 and rs12976445 contributed to cancer susceptibility in the Chinese population and also revealed a significant association between rs10754339 and breast cancer risk, as well as between rs12976445 and lung cancer risk.</p></div><div><h3>Conclusion</h3><p>The <em>B7-H4</em> gene rs10754339 and <em>miR-125a</em> gene rs12976445 may be the potential genetic markers for cancer susceptibility in the Chinese population, which should be validated in future studies with larger sample sizes in other ethnic populations.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 9","pages":"Pages 814-825"},"PeriodicalIF":3.5,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49749091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shuang MENG , Bei Bei MIAO , Jie LI , Jian Wen YIN , Ze Liang LIU , Xue Qi JIANG , Xin Yi GONG , Juan LI
Leclercia adecarboxylata is a Gram-negative bacterium belonging to the Enterobacteriaceae family. To our knowledge, this is the first report of a carbapenem-resistant L. adecarboxylata strain isolated from a healthy newborn. The L. adecarboxylata strain isolated in this study carried four plasmids that may serve as reservoirs for antibiotic resistance genes. Plasmids 2 and 4 did not harbor any antimicrobial resistance genes. Plasmid 3 is a novel plasmid containing three resistance genes. The bla IMP gene harbored in the strain was most similar to bla IMP-79 at the nucleotide level, with a similarity of 99.4% (737/741). This case highlights the importance of considering L. adecarboxylata as a potential cause of infections in children.
{"title":"Isolation of Leclercia adecarboxylata Producing Carbapenemases in A Newborn Female","authors":"Shuang MENG , Bei Bei MIAO , Jie LI , Jian Wen YIN , Ze Liang LIU , Xue Qi JIANG , Xin Yi GONG , Juan LI","doi":"10.3967/bes2023.104","DOIUrl":"https://doi.org/10.3967/bes2023.104","url":null,"abstract":"Leclercia adecarboxylata is a Gram-negative bacterium belonging to the Enterobacteriaceae family. To our knowledge, this is the first report of a carbapenem-resistant L. adecarboxylata strain isolated from a healthy newborn. The L. adecarboxylata strain isolated in this study carried four plasmids that may serve as reservoirs for antibiotic resistance genes. Plasmids 2 and 4 did not harbor any antimicrobial resistance genes. Plasmid 3 is a novel plasmid containing three resistance genes. The bla IMP gene harbored in the strain was most similar to bla IMP-79 at the nucleotide level, with a similarity of 99.4% (737/741). This case highlights the importance of considering L. adecarboxylata as a potential cause of infections in children.","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 9","pages":"Pages 874-879"},"PeriodicalIF":3.5,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49758945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chao WU , Qiong Yu ZHANG , Ling LI , Xu Xia ZHANG , Yong Chen CAI , Jin Gang YANG , Hai Yan XU , Yan Yan ZHAO , Yang WANG , Wei LI , Chen JIN , Xiao Jin GAO , Yue Jin YANG , Shu Bin QIAO
Objective
To evaluate the long-term prognosis of patients with ST-segment elevation myocardial infarction (STEMI) treated with different reperfusion strategies in Chinese county-level hospitals
Methods
A total of 2,514 patients with STEMI from 32 hospitals participated in the China Acute Myocardial Infarction registry between January 2013 and September 2014. The success of fibrinolysis was assessed according to indirect measures of vascular recanalization. The primary outcome was 2-year mortality.
Results
Reperfusion therapy was used in 1,080 patients (42.9%): fibrinolysis (n = 664, 61.5%) and primary percutaneous coronary intervention (PCI) (n = 416, 38.5%). The most common reason for missing reperfusion therapy was a prehospital delay > 12 h (43%). Fibrinolysis [14.5%, hazard ratio (HR): 0.59, 95% confidence interval (CI) 0.44–0.80] and primary PCI (6.8%, HR = 0.32, 95% CI: 0.22–0.48) were associated with lower 2-year mortality than those with no reperfusion (28.5%). Among fibrinolysis-treated patients, 510 (76.8%) achieved successful clinical reperfusion; only 17.0% of those with failed fibrinolysis underwent rescue PCI. There was no difference in 2-year mortality between successful fibrinolysis and primary PCI (8.8% vs. 6.8%, HR = 1.53, 95% CI: 0.85–2.73). Failed fibrinolysis predicted a similar mortality (33.1%) to no reperfusion (33.1% vs. 28.5%, HR = 1.30, 95% CI: 0.93–1.81).
Conclusion
In Chinese county-level hospitals, only approximately 2/5 of patients with STEMI underwent reperfusion therapy, largely due to prehospital delay. Approximately 30% of patients with failed fibrinolysis and no reperfusion therapy did not survive at 2 years. Quality improvement initiatives are warranted, especially in public health education and fast referral for mechanical revascularization in cases of failed fibrinolysis.
{"title":"Long-Term Prognosis of Different Reperfusion Strategies for ST-Segment Elevation Myocardial Infarction in Chinese County-Level Hospitals: Insight from China Acute Myocardial Infarction Registry","authors":"Chao WU , Qiong Yu ZHANG , Ling LI , Xu Xia ZHANG , Yong Chen CAI , Jin Gang YANG , Hai Yan XU , Yan Yan ZHAO , Yang WANG , Wei LI , Chen JIN , Xiao Jin GAO , Yue Jin YANG , Shu Bin QIAO","doi":"10.3967/bes2023.110","DOIUrl":"10.3967/bes2023.110","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the long-term prognosis of patients with ST-segment elevation myocardial infarction (STEMI) treated with different reperfusion strategies in Chinese county-level hospitals</p></div><div><h3>Methods</h3><p>A total of 2,514 patients with STEMI from 32 hospitals participated in the China Acute Myocardial Infarction registry between January 2013 and September 2014. The success of fibrinolysis was assessed according to indirect measures of vascular recanalization. The primary outcome was 2-year mortality.</p></div><div><h3>Results</h3><p>Reperfusion therapy was used in 1,080 patients (42.9%): fibrinolysis (<em>n</em> = 664, 61.5%) and primary percutaneous coronary intervention (PCI) (<em>n</em> = 416, 38.5%). The most common reason for missing reperfusion therapy was a prehospital delay > 12 h (43%). Fibrinolysis [14.5%, hazard ratio (<em>HR</em>): 0.59, 95% confidence interval (<em>CI</em>) 0.44–0.80] and primary PCI (6.8%, <em>HR</em> = 0.32, 95% <em>CI</em>: 0.22–0.48) were associated with lower 2-year mortality than those with no reperfusion (28.5%). Among fibrinolysis-treated patients, 510 (76.8%) achieved successful clinical reperfusion; only 17.0% of those with failed fibrinolysis underwent rescue PCI. There was no difference in 2-year mortality between successful fibrinolysis and primary PCI (8.8% <em>vs.</em> 6.8%, <em>HR</em> = 1.53, 95% <em>CI</em>: 0.85–2.73). Failed fibrinolysis predicted a similar mortality (33.1%) to no reperfusion (33.1% <em>vs.</em> 28.5%, <em>HR</em> = 1.30, 95% <em>CI</em>: 0.93–1.81).</p></div><div><h3>Conclusion</h3><p>In Chinese county-level hospitals, only approximately 2/5 of patients with STEMI underwent reperfusion therapy, largely due to prehospital delay. Approximately 30% of patients with failed fibrinolysis and no reperfusion therapy did not survive at 2 years. Quality improvement initiatives are warranted, especially in public health education and fast referral for mechanical revascularization in cases of failed fibrinolysis.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 9","pages":"Pages 826-836"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41125234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
De E YU , Yu Jun XU , Mu LI , Yuan YANG , Hua Yue LIANG , Shan Mei ZHONG , Cai QIN , Ya Nan LAN , Da Wei LI , Ji Peng YU , Yuan PANG , Xue Qiu QIN , Hao LIANG , Kao Kao ZHU , Li YE , Bing Yu LIANG
Objective
This study aimed to determine the HIV-1 subtype distribution and HIV drug resistance (HIVDR) in patients with ART failure from 2014 to 2020 in Hainan, China.
Methods
A 7-year cross-sectional study was conducted among HIV/AIDS patients with ART failure in Hainan. We used online subtyping tools and the maximum likelihood phylogenetic tree to confirm the HIV subtypes with pol sequences. Drug resistance mutations (DRMs) were analyzed using the Stanford University HIV Drug Resistance Database.
Results
A total of 307 HIV-infected patients with ART failure were included, and 241 available pol sequences were obtained. Among 241 patients, CRF01_AE accounted for 68.88%, followed by CRF07_BC (17.00%) and eight other subtypes (14.12%). The overall prevalence of HIVDR was 61.41%, and the HIVDR against non-nucleoside reverse transcriptase inhibitors (NNRTIs), nucleotide reverse transcriptase inhibitors (NRTIs), and protease inhibitors (PIs) were 59.75%, 45.64%, and 2.49%, respectively. Unemployed patients, hypoimmunity or opportunistic infections in individuals, and samples from 2017 to 2020 increased the odd ratios of HIVDR. Also, HIVDR was less likely to affect female patients. The common DRMs to NNRTIs were K103N (21.99%) and Y181C (20.33%), and M184V (28.21%) and K65R (19.09%) were the main DRMs against NRTIs.
Conclusion
The present study highlights the HIV-1 subtype diversity in Hainan and the importance of HIVDR surveillance over a long period.
{"title":"HIV-1 Subtype Diversity and Factors Affecting Drug Resistance among Patients with Virologic Failure in Antiretroviral Therapy in Hainan Province, China, 2014–2020","authors":"De E YU , Yu Jun XU , Mu LI , Yuan YANG , Hua Yue LIANG , Shan Mei ZHONG , Cai QIN , Ya Nan LAN , Da Wei LI , Ji Peng YU , Yuan PANG , Xue Qiu QIN , Hao LIANG , Kao Kao ZHU , Li YE , Bing Yu LIANG","doi":"10.3967/bes2023.077","DOIUrl":"10.3967/bes2023.077","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to determine the HIV-1 subtype distribution and HIV drug resistance (HIVDR) in patients with ART failure from 2014 to 2020 in Hainan, China.</p></div><div><h3>Methods</h3><p>A 7-year cross-sectional study was conducted among HIV/AIDS patients with ART failure in Hainan. We used online subtyping tools and the maximum likelihood phylogenetic tree to confirm the HIV subtypes with <em>pol</em> sequences. Drug resistance mutations (DRMs) were analyzed using the Stanford University HIV Drug Resistance Database.</p></div><div><h3>Results</h3><p>A total of 307 HIV-infected patients with ART failure were included, and 241 available <em>pol</em> sequences were obtained. Among 241 patients, CRF01_AE accounted for 68.88%, followed by CRF07_BC (17.00%) and eight other subtypes (14.12%). The overall prevalence of HIVDR was 61.41%, and the HIVDR against non-nucleoside reverse transcriptase inhibitors (NNRTIs), nucleotide reverse transcriptase inhibitors (NRTIs), and protease inhibitors (PIs) were 59.75%, 45.64%, and 2.49%, respectively. Unemployed patients, hypoimmunity or opportunistic infections in individuals, and samples from 2017 to 2020 increased the odd ratios of HIVDR. Also, HIVDR was less likely to affect female patients. The common DRMs to NNRTIs were K103N (21.99%) and Y181C (20.33%), and M184V (28.21%) and K65R (19.09%) were the main DRMs against NRTIs.</p></div><div><h3>Conclusion</h3><p>The present study highlights the HIV-1 subtype diversity in Hainan and the importance of HIVDR surveillance over a long period.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 9","pages":"Pages 800-813"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41175599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mun Khin Alson LOH , Zhen Yun SIEW , Pooi Pooi LEONG , Rhun Yian KOH , Soi Moi CHYE , Siew Tung WONG , Kenny VOON
Pteropine orthoreovirus (PRV) is a non-enveloped double-stranded RNA (dsRNA) virus of the genus Orthoreovirus under the family Reoviridae
{"title":"Pteropine Orthoreovirus (PRV7S) does not Establish Persistent Infection in NP460 Cells but with Inflammatory Response Triggered","authors":"Mun Khin Alson LOH , Zhen Yun SIEW , Pooi Pooi LEONG , Rhun Yian KOH , Soi Moi CHYE , Siew Tung WONG , Kenny VOON","doi":"10.3967/bes2023.114","DOIUrl":"10.3967/bes2023.114","url":null,"abstract":"Pteropine orthoreovirus (PRV) is a non-enveloped double-stranded RNA (dsRNA) virus of the genus Orthoreovirus under the family Reoviridae","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 9","pages":"Pages 886-891"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41144869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shan WANG , Yu Bing ZENG , Pei PEI , Xue Jia HE , Fan LIU , Yi WANG , Ting ZHANG
Objective
Circular RNAs (circRNAs) participate in several important pathological processes and have been used in the diagnosis and treatment of various diseases. This study aimed to investigate the role of circRNAs in neural tube defects (NTDs).
Method
We characterized circRNA-associated competitive endogenous RNA (ceRNA) networks in brain tissue of low folate -induced NTDs mouse at embryonic day 13.5 by high-throughput sequencing. The expression levels of Circzfp644, miR-20-5p and Gas7 were detected by RT-PCR. Gas7 and Circzfp644 functions were determined by miRNA-mimics and inhibitors in mouse teratocarcinoma cells (F9 cells), and luciferase gene reporter assay was assessed in the F9 cells. In addition, the expression levels of Circzfp644, miR-20-5p and Gas7 were determined by Nanostring in human NTDs tissues.
Results
We detected 57 circRNA transcripts, 16 miRNAs, and 148 mRNAs that were significantly dysregulated in NTDs brain tissues compared with their expression levels in control (normal) tissues. Circzfp644 shared miRNA response elements with the growth arrest specific 7 (Gas7) gene and competitively bound with miR-20-5p to increase the expression of Gas7. Downregulation of Circzfp644 and Gas7 and upregulation of miR-20-5p were found in human NTD tissue.
Conclusion
This study provides new perspectives on the role of circRNAs in nervous system development and the pathogenesis of NTDs.
{"title":"Characterization of CircRNA-Associated CeRNA Networks in Folate Deficiency-Induced Neural Tube Defects","authors":"Shan WANG , Yu Bing ZENG , Pei PEI , Xue Jia HE , Fan LIU , Yi WANG , Ting ZHANG","doi":"10.3967/bes2023.071","DOIUrl":"10.3967/bes2023.071","url":null,"abstract":"<div><h3>Objective</h3><p>Circular RNAs (circRNAs) participate in several important pathological processes and have been used in the diagnosis and treatment of various diseases. This study aimed to investigate the role of circRNAs in neural tube defects (NTDs).</p></div><div><h3>Method</h3><p>We characterized circRNA-associated competitive endogenous RNA (ceRNA) networks in brain tissue of low folate -induced NTDs mouse at embryonic day 13.5 by high-throughput sequencing. The expression levels of Circzfp644, miR-20-5p and <em>Gas7</em> were detected by RT-PCR. <em>Gas7</em> and Circzfp644 functions were determined by miRNA-mimics and inhibitors in mouse teratocarcinoma cells (F9 cells), and luciferase gene reporter assay was assessed in the F9 cells. In addition, the expression levels of Circzfp644, miR-20-5p and <em>Gas7</em> were determined by Nanostring in human NTDs tissues.</p></div><div><h3>Results</h3><p>We detected 57 circRNA transcripts, 16 miRNAs, and 148 mRNAs that were significantly dysregulated in NTDs brain tissues compared with their expression levels in control (normal) tissues. Circzfp644 shared miRNA response elements with the growth arrest specific 7 (<em>Gas7</em>) gene and competitively bound with miR-20-5p to increase the expression of <em>Gas7</em>. Downregulation of Circzfp644 and <em>Gas7</em> and upregulation of miR-20-5p were found in human NTD tissue.</p></div><div><h3>Conclusion</h3><p>This study provides new perspectives on the role of circRNAs in nervous system development and the pathogenesis of NTDs.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 9","pages":"Pages 837-849"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41157963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jian ZHAO, Yu Lin SHI, Yu Tong WANG, Fei Ling AI, Xue Wei WANG, Wen Yi YANG, Jing Xin WANG, Li Mei AI, Kui Ru HU, Xia WAN
Objective
No consensus exists on the relative risk (RR) of lung cancer (LC) attributable to active smoking in China. This study aimed to evaluate the unified RR of LC attributable to active smoking among the Chinese population.
Methods
A systematic literature search of seven databases was conducted to identify studies reporting active smoking among smokers versus nonsmokers in China. Primary articles on LC providing risk estimates with their 95% confidence intervals (CIs) for “ever” “former” or “current” smokers from China were selected. Meta-analysis was used to estimate the pooled RR of active smoking.
Results
Forty-four unique studies were included. Compared with that of nonsmokers, the pooled RR (95% CI) for “ever” “former” and “current” smokers were 3.26 (2.79–3.82), 2.95 (1.71–5.08), and 5.16 (2.58–10.34) among men, 3.18 (2.78–3.63), 2.70 (2.08–3.51), and 4.27 (3.61–5.06) among women, and 2.71 (2.12–3.46), 2.66 (2.45–2.88), and 4.21 (3.25–5.45) in both sexes combined, respectively.
Conclusion
The RR of LC has remained relatively stable (range, 2–6) over the past four decades in China. Early quitting of smoking could reduce the RR to some extent; however, completely refraining from smoking is the best way to avoid its adverse effects.
{"title":"Lung Cancer Risk Attributable to Active Smoking in China: A Systematic Review and Meta-Analysis","authors":"Jian ZHAO, Yu Lin SHI, Yu Tong WANG, Fei Ling AI, Xue Wei WANG, Wen Yi YANG, Jing Xin WANG, Li Mei AI, Kui Ru HU, Xia WAN","doi":"10.3967/bes2023.075","DOIUrl":"10.3967/bes2023.075","url":null,"abstract":"<div><h3>Objective</h3><p>No consensus exists on the relative risk (<em>RR</em>) of lung cancer (LC) attributable to active smoking in China. This study aimed to evaluate the unified <em>RR</em> of LC attributable to active smoking among the Chinese population.</p></div><div><h3>Methods</h3><p>A systematic literature search of seven databases was conducted to identify studies reporting active smoking among smokers <em>versus</em> nonsmokers in China. Primary articles on LC providing risk estimates with their 95% confidence intervals (<em>CI</em>s) for “ever” “former” or “current” smokers from China were selected. Meta-analysis was used to estimate the pooled <em>RR</em> of active smoking.</p></div><div><h3>Results</h3><p>Forty-four unique studies were included. Compared with that of nonsmokers, the pooled <em>RR</em> (95% <em>CI</em>) for “ever” “former” and “current” smokers were 3.26 (2.79–3.82), 2.95 (1.71–5.08), and 5.16 (2.58–10.34) among men, 3.18 (2.78–3.63), 2.70 (2.08–3.51), and 4.27 (3.61–5.06) among women, and 2.71 (2.12–3.46), 2.66 (2.45–2.88), and 4.21 (3.25–5.45) in both sexes combined, respectively.</p></div><div><h3>Conclusion</h3><p>The <em>RR</em> of LC has remained relatively stable (range, 2–6) over the past four decades in China. Early quitting of smoking could reduce the <em>RR</em> to some extent; however, completely refraining from smoking is the best way to avoid its adverse effects.</p></div>","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 9","pages":"Pages 850-861"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41174593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shuang MENG , Bei Bei MIAO , Jie LI , Jian Wen YIN , Ze Liang LIU , Xue Qi JIANG , Xin Yi GONG , Juan LI
{"title":"Isolation of Leclercia adecarboxylata Producing Carbapenemases in A Newborn Female","authors":"Shuang MENG , Bei Bei MIAO , Jie LI , Jian Wen YIN , Ze Liang LIU , Xue Qi JIANG , Xin Yi GONG , Juan LI","doi":"10.3967/bes2023.104","DOIUrl":"https://doi.org/10.3967/bes2023.104","url":null,"abstract":"","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 9","pages":"Pages 874-879"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49894469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dietary Guide for Hyperuricemia and Gout Patients (WS/T 560—2017)","authors":"","doi":"10.3967/bes2023.118","DOIUrl":"10.3967/bes2023.118","url":null,"abstract":"","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 9","pages":"Pages 897-898"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41144868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Li LIU , Yu Han SHAO , En Qiang FENG , Zhu Gang SHAO , Dong Ming XING
{"title":"Risk of Developing Non-Alcoholic Fatty Liver Disease Over Time in a Cohort of the Elderly in Qingdao, China","authors":"Li LIU , Yu Han SHAO , En Qiang FENG , Zhu Gang SHAO , Dong Ming XING","doi":"10.3967/bes2023.101","DOIUrl":"10.3967/bes2023.101","url":null,"abstract":"","PeriodicalId":55364,"journal":{"name":"Biomedical and Environmental Sciences","volume":"36 8","pages":"Pages 760-767"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10284862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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