首页 > 最新文献

American Journal of Sports Medicine最新文献

英文 中文
Tranexamic Acid for Rotator Cuff Repair: A Systematic Review and Meta-analysis of Randomized Controlled Trials. 氨甲环酸用于肩袖修复术:随机对照试验的系统回顾和元分析》。
IF 4.2 1区 医学 Q1 ORTHOPEDICS Pub Date : 2024-12-01 Epub Date: 2024-02-12 DOI: 10.1177/03635465231216336
Eoghan T Hurley, Kaitlyn Rodriguez, Mark P Karavan, Jay M Levin, Joshua Helmkamp, Oke Anakwenze, Michael J Alaia, Christopher S Klifto

Background: Several randomized controlled trials (RCTs) have been conducted to assess the use of tranexamic acid (TXA) in the setting of arthroscopic rotator cuff repair (ARCR). However, these studies have shown mixed results, with some showing improved intraoperative visualization, subsequent operative times, and pain levels, and others finding no difference.

Purpose: To perform a systematic review of the RCTs in the literature to evaluate the use of TXA on ARCR.

Study design: Meta-analysis; Level of evidence, 1.

Methods: Two independent reviewers performed the literature search based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, with a third author resolving any discrepancies. RCTs comparing TXA with a control in ARCR were included. Visualization, postoperative pain, operative time, pump pressures, and shoulder swelling were evaluated. A P value < .05 was deemed statistically significant.

Results: Six RCTs with 450 patients were included in this review. Overall, 5 studies evaluated intraoperative visualization, with 3 studies finding a significant difference in favor of TXA. With TXA, patients had a lower mean postoperative visual analog scale (VAS) score of 3.3, and with the control, patients had a mean VAS score of 4.1, which was statistically significant (P = .001). With TXA, the mean weighted operation time was 79.3 minutes, and with the control, the mean operation time was 88.8 minutes, which was statistically significant (P = .001). No study found any difference in intraoperative pump pressures or swelling.

Conclusion: TXA improved visualization, operative time, and subsequent postoperative pain levels in patients undergoing ARCR.

背景:已有多项随机对照试验(RCT)评估了在关节镜下肩袖修复术(ARCR)中使用氨甲环酸(TXA)的情况。目的:对文献中评估在 ARCR 中使用氨甲环酸的 RCT 进行系统回顾:研究设计:荟萃分析;证据等级,1.方法:两位独立审稿人根据PRISMA(系统综述和Meta分析首选报告项目)指南进行文献检索,由第三位作者解决任何差异。纳入了在 ARCR 中比较 TXA 与对照组的 RCT。对视野、术后疼痛、手术时间、泵压和肩部肿胀进行了评估。结果:本综述共纳入六项研究,450 名患者。共有 5 项研究对术中可视化进行了评估,其中 3 项研究发现 TXA 有显著差异。使用 TXA 时,患者术后的平均视觉模拟量表(VAS)评分较低,为 3.3 分,而使用对照组时,患者的平均视觉模拟量表评分为 4.1 分,差异有统计学意义(P = .001)。使用 TXA 时,平均加权手术时间为 79.3 分钟,而使用对照组时,平均手术时间为 88.8 分钟,差异有统计学意义(P = .001)。没有研究发现术中泵压或肿胀有任何差异:结论:TXA 可改善 ARCR 患者的视野、手术时间和术后疼痛程度。
{"title":"Tranexamic Acid for Rotator Cuff Repair: A Systematic Review and Meta-analysis of Randomized Controlled Trials.","authors":"Eoghan T Hurley, Kaitlyn Rodriguez, Mark P Karavan, Jay M Levin, Joshua Helmkamp, Oke Anakwenze, Michael J Alaia, Christopher S Klifto","doi":"10.1177/03635465231216336","DOIUrl":"10.1177/03635465231216336","url":null,"abstract":"<p><strong>Background: </strong>Several randomized controlled trials (RCTs) have been conducted to assess the use of tranexamic acid (TXA) in the setting of arthroscopic rotator cuff repair (ARCR). However, these studies have shown mixed results, with some showing improved intraoperative visualization, subsequent operative times, and pain levels, and others finding no difference.</p><p><strong>Purpose: </strong>To perform a systematic review of the RCTs in the literature to evaluate the use of TXA on ARCR.</p><p><strong>Study design: </strong>Meta-analysis; Level of evidence, 1.</p><p><strong>Methods: </strong>Two independent reviewers performed the literature search based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, with a third author resolving any discrepancies. RCTs comparing TXA with a control in ARCR were included. Visualization, postoperative pain, operative time, pump pressures, and shoulder swelling were evaluated. A <i>P</i> value < .05 was deemed statistically significant.</p><p><strong>Results: </strong>Six RCTs with 450 patients were included in this review. Overall, 5 studies evaluated intraoperative visualization, with 3 studies finding a significant difference in favor of TXA. With TXA, patients had a lower mean postoperative visual analog scale (VAS) score of 3.3, and with the control, patients had a mean VAS score of 4.1, which was statistically significant (<i>P</i> = .001). With TXA, the mean weighted operation time was 79.3 minutes, and with the control, the mean operation time was 88.8 minutes, which was statistically significant (<i>P</i> = .001). No study found any difference in intraoperative pump pressures or swelling.</p><p><strong>Conclusion: </strong>TXA improved visualization, operative time, and subsequent postoperative pain levels in patients undergoing ARCR.</p>","PeriodicalId":55528,"journal":{"name":"American Journal of Sports Medicine","volume":" ","pages":"3673-3679"},"PeriodicalIF":4.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139725094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing Clinical Outcomes and Knee Stability in Remnant-Preserving ACL Reconstruction Versus Standard ACL Reconstruction: A Systematic Review and Meta-analysis. 保留残余前交叉韧带重建与标准前交叉韧带重建的临床效果和膝关节稳定性比较:系统回顾与元分析》。
IF 4.2 1区 医学 Q1 ORTHOPEDICS Pub Date : 2024-12-01 Epub Date: 2024-03-29 DOI: 10.1177/03635465231225984
Felicitas Allende, Sachin Allahabadi, Divesh Sachdev, Varun Gopinatth, Rodrigo Saad Berreta, Robert F LaPrade, Jorge Chahla

Background: Anterior cruciate ligament reconstruction (ACLR) is one of the most frequently performed procedures in sports medicine, and undesirable outcomes still may range from 3-18%. One technique that has been explored to improve outcomes is preservation of the ACL remnant tibial stump, as opposed to stump debridement, at the time of reconstruction.

Purpose: To review current high-level evidence and compare remnant-preserving anterior cruciate ligament reconstruction (ACLR) versus standard ACLR in terms of clinical outcomes and measures of knee stability.

Hypothesis: ACLR with remnant preservation would result in improved clinical outcomes and knee stability measures.

Study design: Systematic review; Level of evidence, 2.

Methods: A systematic review of randomized controlled trials (RCTs) and cohort studies comparing remnant-preserving ACLR with standard ACLR with a minimum level of evidence of 2 was performed. Extracted data were summarized as general information, surgical characteristics, postoperative clinical outcomes, knee stability, graft evaluation, tunnel assessment, and postoperative complications. When feasible, a meta-analysis was performed.

Results: Seven RCTs and 5 cohort studies met the inclusion criteria. In total, 518 patients underwent remnant-preserving ACLR and 604 patients underwent standard ACLR. Ten studies performed the reconstruction with hamstring tendon (HT) autografts, 1 study with HT and bone-patellar tendon-bone autografts, and 1 study with HT and tibialis anterior allografts. On meta-analysis, remnant-preserving ACLR provided comparable outcomes with respect to International Knee Documentation Committee grades or Tegner scores. Even though there was a significant improvement in Lysholm scores (mean difference, -1.9; 95% CI, -2.89 to -0.91; P = .0002) with the remnant-preserving technique, this did not exceed previously reported minimal clinically important difference values. Remnant-preserving ACLR demonstrated superior knee stability in terms of patients achieving negative pivot shift when compared with the control group (88.89% vs 79.92%; P = .006). Although there was a significant improvement in the side-to-side difference in anterior tibial translation favoring remnant preservation (P = .004), the mean difference was 0.51 mm.

Conclusion: Remnant-preserving ACLR, primarily with HT autografts, results in comparable clinical outcome scores and significantly improved knee stability relative to standard ACLR without remnant preservation without increasing the complication rate. Further studies will help clarify if remnant-preserving ACLR also has benefits in terms of enhancing graft integration and maturation, improving proprioception, limiting tunnel enlargement, and reducing complications.

背景:前交叉韧带重建术(ACLR)是运动医学中最常进行的手术之一,但不良后果仍高达3%-18%。目的:回顾目前的高级别证据,比较保留残端前交叉韧带重建术(ACLR)与标准 ACLR 在临床疗效和膝关节稳定性方面的差异:研究设计:研究设计:系统综述;证据等级,2.方法:方法:对随机对照试验(RCT)和队列研究进行系统综述,比较保留残余前交叉韧带的前交叉韧带置换术与标准前交叉韧带置换术,证据等级至少为 2。提取的数据归纳为一般信息、手术特点、术后临床结果、膝关节稳定性、移植物评估、隧道评估和术后并发症。在可行的情况下,进行荟萃分析:结果:7 项研究性临床试验和 5 项队列研究符合纳入标准。共有 518 名患者接受了保留残余前交叉韧带重建术,604 名患者接受了标准前交叉韧带重建术。10项研究使用腘绳肌腱(HT)自体移植物进行重建,1项研究使用HT和骨-髌腱-骨自体移植物,1项研究使用HT和胫骨前肌异体移植物。根据荟萃分析,保留残余前交叉韧带的手术在国际膝关节文献委员会分级或 Tegner 评分方面具有可比性。尽管残余保留技术显著改善了Lysholm评分(平均差异为-1.9;95% CI为-2.89至-0.91;P = .0002),但这并没有超过之前报道的最小临床重要差异值。与对照组相比(88.89% vs 79.92%; P = .006),保留残余前交叉韧带重建术在实现负枢轴移位的患者膝关节稳定性方面更胜一筹。虽然胫骨前移的侧向差异有了明显改善(P = .004),但平均差异为 0.51 毫米:保留残余物的前交叉韧带置换术(主要使用 HT 自体移植物)与不保留残余物的标准前交叉韧带置换术相比,临床结果评分相当,膝关节稳定性明显改善,且不会增加并发症发生率。进一步的研究将有助于明确保留残余物的前交叉韧带置换术是否也能在增强移植物整合和成熟、改善本体感觉、限制隧道扩大和减少并发症等方面带来益处。
{"title":"Comparing Clinical Outcomes and Knee Stability in Remnant-Preserving ACL Reconstruction Versus Standard ACL Reconstruction: A Systematic Review and Meta-analysis.","authors":"Felicitas Allende, Sachin Allahabadi, Divesh Sachdev, Varun Gopinatth, Rodrigo Saad Berreta, Robert F LaPrade, Jorge Chahla","doi":"10.1177/03635465231225984","DOIUrl":"10.1177/03635465231225984","url":null,"abstract":"<p><strong>Background: </strong>Anterior cruciate ligament reconstruction (ACLR) is one of the most frequently performed procedures in sports medicine, and undesirable outcomes still may range from 3-18%. One technique that has been explored to improve outcomes is preservation of the ACL remnant tibial stump, as opposed to stump debridement, at the time of reconstruction.</p><p><strong>Purpose: </strong>To review current high-level evidence and compare remnant-preserving anterior cruciate ligament reconstruction (ACLR) versus standard ACLR in terms of clinical outcomes and measures of knee stability.</p><p><strong>Hypothesis: </strong>ACLR with remnant preservation would result in improved clinical outcomes and knee stability measures.</p><p><strong>Study design: </strong>Systematic review; Level of evidence, 2.</p><p><strong>Methods: </strong>A systematic review of randomized controlled trials (RCTs) and cohort studies comparing remnant-preserving ACLR with standard ACLR with a minimum level of evidence of 2 was performed. Extracted data were summarized as general information, surgical characteristics, postoperative clinical outcomes, knee stability, graft evaluation, tunnel assessment, and postoperative complications. When feasible, a meta-analysis was performed.</p><p><strong>Results: </strong>Seven RCTs and 5 cohort studies met the inclusion criteria. In total, 518 patients underwent remnant-preserving ACLR and 604 patients underwent standard ACLR. Ten studies performed the reconstruction with hamstring tendon (HT) autografts, 1 study with HT and bone-patellar tendon-bone autografts, and 1 study with HT and tibialis anterior allografts. On meta-analysis, remnant-preserving ACLR provided comparable outcomes with respect to International Knee Documentation Committee grades or Tegner scores. Even though there was a significant improvement in Lysholm scores (mean difference, -1.9; 95% CI, -2.89 to -0.91; <i>P</i> = .0002) with the remnant-preserving technique, this did not exceed previously reported minimal clinically important difference values. Remnant-preserving ACLR demonstrated superior knee stability in terms of patients achieving negative pivot shift when compared with the control group (88.89% vs 79.92%; <i>P</i> = .006). Although there was a significant improvement in the side-to-side difference in anterior tibial translation favoring remnant preservation (<i>P</i> = .004), the mean difference was 0.51 mm.</p><p><strong>Conclusion: </strong>Remnant-preserving ACLR, primarily with HT autografts, results in comparable clinical outcome scores and significantly improved knee stability relative to standard ACLR without remnant preservation without increasing the complication rate. Further studies will help clarify if remnant-preserving ACLR also has benefits in terms of enhancing graft integration and maturation, improving proprioception, limiting tunnel enlargement, and reducing complications.</p>","PeriodicalId":55528,"journal":{"name":"American Journal of Sports Medicine","volume":" ","pages":"3651-3661"},"PeriodicalIF":4.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140319959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Subscapularis Muscle Radiographic Integrity and Patient-Reported Outcomes Following Arthroscopic Anatomic Glenoid Reconstruction With Distal Tibial Allograft. 使用胫骨远端同种异体移植进行关节镜解剖盂成形术重建后肩胛下肌肉的放射学完整性和患者报告的结果
IF 4.2 1区 医学 Q1 ORTHOPEDICS Pub Date : 2024-12-01 Epub Date: 2024-11-14 DOI: 10.1177/03635465241291843
Jose Castillo de la Peña, Peter N Chalmers, Jie Ma, Ivan Wong

Background: Shoulder stabilization surgery has evolved over time, and bony augmentation procedures on the glenoid side are being performed more often. The Latarjet procedure modifies subscapularis anatomy because the conjoined tendon divides the subscapularis muscle fibers through a split/takedown, which has structural and functional implications. Arthroscopic anatomic glenoid reconstruction (AAGR) re-creates anatomy. This technique uses the Halifax portal to deploy and fix a distal tibial allograft (DTA) through the rotator interval, thus preserving the subscapularis anatomy.

Purpose/hypothesis: The purpose was to analyze the radiographic properties of the subscapularis muscle after AAGR. It was hypothesized that the subscapularis muscle structure remains preserved postoperatively.

Study design: Case series; Level of evidence, 4.

Methods: A retrospective review was performed comprising a consecutive series of patients treated with AAGR with DTA between November 2012 and April 2021 for traumatic anterior shoulder instability with glenoid bone loss. Patients were excluded if they had posterior instability, glenoid fracture, missing pre- or postoperative computed tomography (CT) scans, or only CT arthrogram available. Radiographic variables measured on CT scans included estimates of subscapularis muscle volume, subscapularis/infraspinatus muscle ratio, and fatty infiltration according to the Goutallier classification. Pre- and postoperative Western Ontario Shoulder Instability index scores were collected as a secondary outcome of this study.

Results: Ninety-three patients were included in the study with a clinical follow-up of 2.3 ± 1.5 years (mean ± SD). The subscapularis volume increased from 185.91 ± 45.85 mL preoperatively to 194.1 ± 49.0 mL postoperatively (P = .006). The subscapularis to infraspinatus muscle ratio showed a significant increase from 0.96 ± 0.27 to 1.05 ± 0.30 after surgery (P = .002). All patients had a Goutallier stage of 0 before and after surgery. The Western Ontario Shoulder Instability scores showed a significant improvement from 64.8 ± 15.5 preoperatively to 28.2 ± 24.0 postoperatively (P < .001).

Conclusion: Patients who undergo AAGR with DTA for traumatic shoulder instability with glenoid bone loss have a preserved subscapularis muscle volume with no fatty infiltration, while showing a significant improvement in clinical outcomes.

背景:随着时间的推移,肩部稳定手术也在不断发展,盂侧骨质增强手术也越来越多。Latarjet手术改变了肩胛下肌的解剖结构,因为连体肌腱通过分裂/撕脱将肩胛下肌纤维分开,这对结构和功能都有影响。关节镜解剖盂重建(AAGR)可重新创建解剖结构。该技术使用哈利法克斯门户,通过转子间隙展开并固定胫骨远端同种异体移植物(DTA),从而保留肩胛下肌的解剖结构:目的是分析 AAGR 术后肩胛下肌的影像学特性。假设术后仍保留肩胛下肌结构:研究设计:病例系列;证据等级,4.方法:方法:对2012年11月至2021年4月期间因外伤性肩关节前部不稳定伴盂骨缺失而接受AAGR和DTA治疗的患者进行回顾性分析。如果患者存在后方不稳、盂骨骨折、术前或术后计算机断层扫描(CT)缺失,或仅有CT关节造影可用,则将其排除在外。CT扫描测量的放射学变量包括肩胛下肌体积、肩胛下肌/冈下肌比例以及根据Goutallier分类法得出的脂肪浸润估计值。作为本研究的次要结果,还收集了术前和术后西安大略省肩关节不稳定性指数评分:研究共纳入 93 名患者,临床随访 2.3 ± 1.5 年(平均 ± SD)。肩胛下肌体积从术前的 185.91 ± 45.85 mL 增加到术后的 194.1 ± 49.0 mL(P = .006)。肩胛下肌与冈下肌的比例从术前的 0.96 ± 0.27 显著增加到术后的 1.05 ± 0.30(P = .002)。所有患者术前和术后的 Goutallier 阶段均为 0。西安大略省肩关节不稳定性评分从术前的 64.8 ± 15.5 显著改善到术后的 28.2 ± 24.0(P < .001):结论:接受AAGR和DTA治疗外伤性肩关节不稳定伴盂骨缺失的患者可保留肩胛下肌体积,且无脂肪浸润,同时临床疗效显著改善。
{"title":"Subscapularis Muscle Radiographic Integrity and Patient-Reported Outcomes Following Arthroscopic Anatomic Glenoid Reconstruction With Distal Tibial Allograft.","authors":"Jose Castillo de la Peña, Peter N Chalmers, Jie Ma, Ivan Wong","doi":"10.1177/03635465241291843","DOIUrl":"10.1177/03635465241291843","url":null,"abstract":"<p><strong>Background: </strong>Shoulder stabilization surgery has evolved over time, and bony augmentation procedures on the glenoid side are being performed more often. The Latarjet procedure modifies subscapularis anatomy because the conjoined tendon divides the subscapularis muscle fibers through a split/takedown, which has structural and functional implications. Arthroscopic anatomic glenoid reconstruction (AAGR) re-creates anatomy. This technique uses the Halifax portal to deploy and fix a distal tibial allograft (DTA) through the rotator interval, thus preserving the subscapularis anatomy.</p><p><strong>Purpose/hypothesis: </strong>The purpose was to analyze the radiographic properties of the subscapularis muscle after AAGR. It was hypothesized that the subscapularis muscle structure remains preserved postoperatively.</p><p><strong>Study design: </strong>Case series; Level of evidence, 4.</p><p><strong>Methods: </strong>A retrospective review was performed comprising a consecutive series of patients treated with AAGR with DTA between November 2012 and April 2021 for traumatic anterior shoulder instability with glenoid bone loss. Patients were excluded if they had posterior instability, glenoid fracture, missing pre- or postoperative computed tomography (CT) scans, or only CT arthrogram available. Radiographic variables measured on CT scans included estimates of subscapularis muscle volume, subscapularis/infraspinatus muscle ratio, and fatty infiltration according to the Goutallier classification. Pre- and postoperative Western Ontario Shoulder Instability index scores were collected as a secondary outcome of this study.</p><p><strong>Results: </strong>Ninety-three patients were included in the study with a clinical follow-up of 2.3 ± 1.5 years (mean ± SD). The subscapularis volume increased from 185.91 ± 45.85 mL preoperatively to 194.1 ± 49.0 mL postoperatively (<i>P</i> = .006). The subscapularis to infraspinatus muscle ratio showed a significant increase from 0.96 ± 0.27 to 1.05 ± 0.30 after surgery (<i>P</i> = .002). All patients had a Goutallier stage of 0 before and after surgery. The Western Ontario Shoulder Instability scores showed a significant improvement from 64.8 ± 15.5 preoperatively to 28.2 ± 24.0 postoperatively (<i>P</i> < .001).</p><p><strong>Conclusion: </strong>Patients who undergo AAGR with DTA for traumatic shoulder instability with glenoid bone loss have a preserved subscapularis muscle volume with no fatty infiltration, while showing a significant improvement in clinical outcomes.</p>","PeriodicalId":55528,"journal":{"name":"American Journal of Sports Medicine","volume":" ","pages":"3480-3487"},"PeriodicalIF":4.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Preoperative Factors That Affect the Alpha Angle of Screw Insertion After the Open Latarjet Procedure. 评估影响开放式 Latarjet 手术后螺钉插入 Alpha 角度的术前因素。
IF 4.2 1区 医学 Q1 ORTHOPEDICS Pub Date : 2024-12-01 Epub Date: 2024-11-15 DOI: 10.1177/03635465241290818
Hee Dong Lee, Su Cheol Kim, Yun Seong Choi, Dae Yeung Kim, Jae Chul Yoo

Background: The open Latarjet procedure yields excellent results as a treatment for anterior shoulder instability. The position of the bony fragment and the insertion angle of the screw (the alpha angle) are critical factors for a successful procedure. The alpha angle is considered overangulated at >25°, which is associated with poor bone fixation and healing.

Purpose: To assess preoperative patient anatomic factors that affect the alpha angle in the Latarjet procedure for anterior shoulder instability.

Study design: Case-control study; Level of evidence, 3.

Methods: In this retrospective study, 76 patients who underwent the open Latarjet procedure between October 2009 and December 2023 were included. Postoperative computed tomography scans were reviewed for the alpha angle, and patients were classified into 2 groups: group 1 (alpha angle ≥25°) and group 2 (alpha angle <25°). Preoperative patient characteristics and radiological parameters obtained from preoperative computed tomography scans were analyzed and compared between groups 1 and 2. We developed a novel method to measure the depth of the chest and the angle between the deltopectoral interval and the plane of screw insertion. We also measured the thickness of the pectoralis major and subscapularis muscles.

Results: Of the 76 patients in this study, 41 and 35 patients were included in groups 1 and 2, respectively. The mean alpha angles of groups 1 and 2 were 36° and 12°, respectively, and the body mass index was significantly higher in group 1 (P < .001). In addition, group 1 had a significantly longer distance from the anterior edge of the glenoid to the skin margin of the deltopectoral interval (P < .001). The angle between the deltopectoral interval and the plane of screw insertion (traction angle) was significantly larger in group 1 (P < .001), and the pectoralis major and subscapularis muscles were thicker in group 1 (P = .017 and P = .032, respectively).

Conclusion: The alpha angle after the Latarjet procedure was strongly related to the patient's weight, body mass index, depth of the chest, and the angle between the deltopectoral interval and the plane of screw insertion. To our knowledge, this is the first study in which the preoperative factors that facilitate proper screw fixation in the Latarjet procedure are reported.

背景:开放式Latarjet手术在治疗肩关节前方不稳定方面效果极佳。骨片的位置和螺钉的插入角度(α角)是手术成功的关键因素。目的:评估影响Latarjet术治疗肩关节前方不稳定的α角的术前患者解剖因素:研究设计:病例对照研究;证据级别:3:在这项回顾性研究中,纳入了在2009年10月至2023年12月期间接受开放式Latarjet手术的76名患者。对术后计算机断层扫描的α角进行复查,并将患者分为两组:第1组(α角≥25°)和第2组(α角≥25°),第3组(α角≥25°)和第4组(α角≥25°):本研究的 76 名患者中,第 1 组和第 2 组分别有 41 名和 35 名患者。第一组和第二组的平均α角分别为 36°和 12°,第一组的体重指数明显更高(P < .001)。此外,第1组从盂前缘到胸骨下间隙皮缘的距离明显更长(P < .001)。第1组的胸骨下间隙与螺钉插入平面之间的角度(牵引角)明显更大(P < .001),第1组的胸大肌和肩胛下肌更厚(分别为P = .017和P = .032):结论:Latarjet 手术后的α角与患者的体重、体重指数、胸廓深度以及胸骨后间隙与螺钉插入平面之间的角度密切相关。据我们所知,这是第一项报告有助于在 Latarjet 手术中正确固定螺钉的术前因素的研究。
{"title":"Evaluation of Preoperative Factors That Affect the Alpha Angle of Screw Insertion After the Open Latarjet Procedure.","authors":"Hee Dong Lee, Su Cheol Kim, Yun Seong Choi, Dae Yeung Kim, Jae Chul Yoo","doi":"10.1177/03635465241290818","DOIUrl":"10.1177/03635465241290818","url":null,"abstract":"<p><strong>Background: </strong>The open Latarjet procedure yields excellent results as a treatment for anterior shoulder instability. The position of the bony fragment and the insertion angle of the screw (the alpha angle) are critical factors for a successful procedure. The alpha angle is considered overangulated at >25°, which is associated with poor bone fixation and healing.</p><p><strong>Purpose: </strong>To assess preoperative patient anatomic factors that affect the alpha angle in the Latarjet procedure for anterior shoulder instability.</p><p><strong>Study design: </strong>Case-control study; Level of evidence, 3.</p><p><strong>Methods: </strong>In this retrospective study, 76 patients who underwent the open Latarjet procedure between October 2009 and December 2023 were included. Postoperative computed tomography scans were reviewed for the alpha angle, and patients were classified into 2 groups: group 1 (alpha angle ≥25°) and group 2 (alpha angle <25°). Preoperative patient characteristics and radiological parameters obtained from preoperative computed tomography scans were analyzed and compared between groups 1 and 2. We developed a novel method to measure the depth of the chest and the angle between the deltopectoral interval and the plane of screw insertion. We also measured the thickness of the pectoralis major and subscapularis muscles.</p><p><strong>Results: </strong>Of the 76 patients in this study, 41 and 35 patients were included in groups 1 and 2, respectively. The mean alpha angles of groups 1 and 2 were 36° and 12°, respectively, and the body mass index was significantly higher in group 1 (<i>P</i> < .001). In addition, group 1 had a significantly longer distance from the anterior edge of the glenoid to the skin margin of the deltopectoral interval (<i>P</i> < .001). The angle between the deltopectoral interval and the plane of screw insertion (traction angle) was significantly larger in group 1 (<i>P</i> < .001), and the pectoralis major and subscapularis muscles were thicker in group 1 (<i>P</i> = .017 and <i>P</i> = .032, respectively).</p><p><strong>Conclusion: </strong>The alpha angle after the Latarjet procedure was strongly related to the patient's weight, body mass index, depth of the chest, and the angle between the deltopectoral interval and the plane of screw insertion. To our knowledge, this is the first study in which the preoperative factors that facilitate proper screw fixation in the Latarjet procedure are reported.</p>","PeriodicalId":55528,"journal":{"name":"American Journal of Sports Medicine","volume":" ","pages":"3488-3494"},"PeriodicalIF":4.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kartogenin-Loaded Exosomes Derived From Bone Marrow Mesenchymal Stem Cells Enhance Chondrogenesis and Expedite Tendon Enthesis Healing in a Rat Model of Rotator Cuff Injury. 从骨髓间充质干细胞提取的Kartogenin-Loaded外泌体在大鼠肩袖损伤模型中增强软骨生成并加速肌腱假体愈合
IF 4.2 1区 医学 Q1 ORTHOPEDICS Pub Date : 2024-12-01 Epub Date: 2024-11-20 DOI: 10.1177/03635465241296141
Yue Wang, Ji-Zheng Qin, Chao-Yu Xie, Xin-Zhou Peng, Jian-Hua Wang, Shao-Jie Wang
<p><strong>Background: </strong>The insufficient regeneration of fibrocartilage at the tendon enthesis is the primary cause of retearing after surgical reattachment of the rotator cuff. Exosomes derived from bone marrow-derived mesenchymal stem cells (BMSC-Exos) and kartogenin (KGN) have been demonstrated to induce fibrocartilage formation. Loading drugs into exosomes may lead to a synergistic effect, significantly enhancing the inherent activity of both components. However, further investigation is necessary to determine whether loading KGN into BMSC-Exos could yield superior efficacy in promoting tendon enthesis healing.</p><p><strong>Purpose: </strong>To study the effect and mechanism of KGN-loaded BMSC-Exos (Kl-BMSC-Exos) on tendon enthesis repair and biomechanical properties in a rat rotator cuff injury (RCI) model.</p><p><strong>Study design: </strong>Controlled laboratory study.</p><p><strong>Methods: </strong>The characteristics and in vivo retention of exosomes were demonstrated using nanoflow cytometry, transmission electron microscopy, and in vivo imaging of a small animal. The differentiation markers of BMSCs were assessed through quantitative polymerase chain reaction and immunofluorescence assays. Unilateral supraspinatus tenotomy and repair were performed in rats to establish the RCI model. Gelatin sponges were utilized to contain and deliver exosomes. In total, 44 rats were randomly assigned to 4 groups: sham, RCI, BMSC-Exos, and Kl-BMSC-Exos. Tendon enthesis regeneration and biomechanical properties were evaluated 8 weeks after surgery. RNA sequencing of BMSCs was performed to elucidate the underlying mechanism through which Kl-BMSC-Exos enhance tendon enthesis healing.</p><p><strong>Results: </strong>No discernible disparities in fundamental characteristics were evident between BMSC-Exos and Kl-BMSC-Exos. Incorporating exosomes into a gelatin sponge extended the in vivo retention time from 7 to 14 days. Kl-BMSC-Exos were more effective in inducing differentiation markers of BMSCs, improving fibrocartilage regeneration, organizing collagen fiber arrangement, and enhancing the biomechanical properties of tendon enthesis. Furthermore, transcriptomics suggested that <i>Mospd1</i> was involved in Kl-BMSC-Exos-mediated tendon enthesis healing by enhancing fibrocartilage regeneration.</p><p><strong>Conclusion: </strong>The incorporation of exosomes into a gelatin sponge significantly enhances their in vivo retention time. Kl-BMSC-Exos can expedite the healing of RCI by enhancing chondrogenesis and fibrocartilage regeneration, providing more organized collagen fiber arrangement and superior biomechanical properties of the rotator cuff enthesis. The promotion of rotator cuff enthesis regeneration may contribute to enhancing the chondrogenic potential in BMSCs through Kl-BMSC-Exos-mediated upregulation of <i>Mospd1</i>.</p><p><strong>Clinical relevance: </strong>As a cell-free therapeutic approach, Kl-BMSC-Exos displayed a better therapeu
背景:肌腱接合处的纤维软骨再生不足是肩袖手术重新接合后再次撕裂的主要原因。从骨髓间充质干细胞(BMSC-Exos)和卡托原蛋白(KGN)中提取的外泌体已被证实能诱导纤维软骨的形成。将药物加入外泌体可能会产生协同效应,显著增强两种成分的固有活性。目的:研究KGN负载的BMSC-Exos(Kl-BMSC-Exos)对大鼠肩袖损伤(RCI)模型中肌腱假体修复和生物力学特性的影响和机制:研究设计:实验室对照研究:利用纳米流式细胞术、透射电子显微镜和小动物体内成像技术证明了外泌体的特征和体内存留情况。通过定量聚合酶链反应和免疫荧光检测评估了BMSCs的分化标记。对大鼠进行单侧冈上肌腱鞘切除和修复,以建立 RCI 模型。明胶海绵用于容纳和输送外泌体。总共 44 只大鼠被随机分配到 4 个组:假组、RCI 组、BMSC-Exos 组和 Kl-BMSC-Exos 组。术后 8 周对肌腱内膜再生和生物力学特性进行评估。对 BMSCs 进行了 RNA 测序,以阐明 Kl-BMSC-Exos 促进腱鞘愈合的内在机制:结果:BMSC-Exos和Kl-BMSC-Exos在基本特征上没有明显差异。将外泌体纳入明胶海绵可将体内保留时间从 7 天延长至 14 天。Kl-BMSC-Exos 在诱导 BMSCs 的分化标志物、改善纤维软骨再生、组织胶原纤维排列和增强肌腱合成的生物力学特性方面更为有效。此外,转录组学研究表明,Mospd1通过促进纤维软骨再生参与了Kl-BMSC-Exos介导的肌腱假体愈合:结论:将外泌体纳入明胶海绵可显著延长其体内存留时间。Kl-BMSC-Exos可通过促进软骨生成和纤维软骨再生来加快RCI的愈合,使肩袖假体的胶原纤维排列更有序,生物力学性能更优越。Kl-BMSC-Exos介导的 Mospd1 上调可能有助于增强 BMSCs 的软骨生成潜能,从而促进肩袖假体的再生:作为一种无细胞治疗方法,Kl-BMSC-Exos 对肌腱内膜愈合的治疗效果优于 BMSC-Exos,可作为一种生物增量剂用于增强肩袖内膜的愈合。
{"title":"Kartogenin-Loaded Exosomes Derived From Bone Marrow Mesenchymal Stem Cells Enhance Chondrogenesis and Expedite Tendon Enthesis Healing in a Rat Model of Rotator Cuff Injury.","authors":"Yue Wang, Ji-Zheng Qin, Chao-Yu Xie, Xin-Zhou Peng, Jian-Hua Wang, Shao-Jie Wang","doi":"10.1177/03635465241296141","DOIUrl":"10.1177/03635465241296141","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The insufficient regeneration of fibrocartilage at the tendon enthesis is the primary cause of retearing after surgical reattachment of the rotator cuff. Exosomes derived from bone marrow-derived mesenchymal stem cells (BMSC-Exos) and kartogenin (KGN) have been demonstrated to induce fibrocartilage formation. Loading drugs into exosomes may lead to a synergistic effect, significantly enhancing the inherent activity of both components. However, further investigation is necessary to determine whether loading KGN into BMSC-Exos could yield superior efficacy in promoting tendon enthesis healing.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;To study the effect and mechanism of KGN-loaded BMSC-Exos (Kl-BMSC-Exos) on tendon enthesis repair and biomechanical properties in a rat rotator cuff injury (RCI) model.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study design: &lt;/strong&gt;Controlled laboratory study.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The characteristics and in vivo retention of exosomes were demonstrated using nanoflow cytometry, transmission electron microscopy, and in vivo imaging of a small animal. The differentiation markers of BMSCs were assessed through quantitative polymerase chain reaction and immunofluorescence assays. Unilateral supraspinatus tenotomy and repair were performed in rats to establish the RCI model. Gelatin sponges were utilized to contain and deliver exosomes. In total, 44 rats were randomly assigned to 4 groups: sham, RCI, BMSC-Exos, and Kl-BMSC-Exos. Tendon enthesis regeneration and biomechanical properties were evaluated 8 weeks after surgery. RNA sequencing of BMSCs was performed to elucidate the underlying mechanism through which Kl-BMSC-Exos enhance tendon enthesis healing.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;No discernible disparities in fundamental characteristics were evident between BMSC-Exos and Kl-BMSC-Exos. Incorporating exosomes into a gelatin sponge extended the in vivo retention time from 7 to 14 days. Kl-BMSC-Exos were more effective in inducing differentiation markers of BMSCs, improving fibrocartilage regeneration, organizing collagen fiber arrangement, and enhancing the biomechanical properties of tendon enthesis. Furthermore, transcriptomics suggested that &lt;i&gt;Mospd1&lt;/i&gt; was involved in Kl-BMSC-Exos-mediated tendon enthesis healing by enhancing fibrocartilage regeneration.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The incorporation of exosomes into a gelatin sponge significantly enhances their in vivo retention time. Kl-BMSC-Exos can expedite the healing of RCI by enhancing chondrogenesis and fibrocartilage regeneration, providing more organized collagen fiber arrangement and superior biomechanical properties of the rotator cuff enthesis. The promotion of rotator cuff enthesis regeneration may contribute to enhancing the chondrogenic potential in BMSCs through Kl-BMSC-Exos-mediated upregulation of &lt;i&gt;Mospd1&lt;/i&gt;.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical relevance: &lt;/strong&gt;As a cell-free therapeutic approach, Kl-BMSC-Exos displayed a better therapeu","PeriodicalId":55528,"journal":{"name":"American Journal of Sports Medicine","volume":" ","pages":"3520-3535"},"PeriodicalIF":4.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel Description of Medial Meniscus Vascularization: A Multicenter Study Introducing the "Medial Meniscal Artery". 内侧半月板血管化的新描述:引入 "内侧半月板动脉 "的多中心研究。
IF 4.2 1区 医学 Q1 ORTHOPEDICS Pub Date : 2024-12-01 Epub Date: 2024-11-22 DOI: 10.1177/03635465241291802
Robert Śmigielski, Eric Azua, Safa Gursoy, Zeeshan A Khan, Enzo S Mameri, Beata Ciszkowska-Łysoń, Bogdan Ciszek, Mario Hevesi, Jakub Piękoś, Aleksandra Zielińska, Bertram Zarins, Jorge Chahla

Background: The microvasculature of the human meniscus has been previously described by Arnoczky and Warren. However, to date, the qualitative and quantitative extra-articular vascular anatomy of the medial meniscus has not been characterized.

Purposes: To perform a qualitative and quantitative anatomic study of the extra-articular medial meniscal vasculature and to introduce the novel "medial meniscal artery" (MMA), potentially providing future guidelines for the treatment of meniscal abnormalities.

Study design: Descriptive laboratory study.

Methods: A total of 33 unpaired, frozen human cadaveric knees were dissected. The femoral artery was identified and cannulated using an angiocatheter. The arteries were perfused with a red acrylic paint solution, allowing for improved visualization. Artery dimensions and distances were measured using a digital caliper. Perfused specimens were imaged using computed tomography and segmented using 3D reconstruction software to identify vessels and repeat artery measurements digitally.

Results: The MMA was consistently identified in all specimens. In 27 (82%) of 33 specimens, the MMA branched directly from the popliteal artery; in 5 (15%), the MMA shared a common trunk with the inferior medial genicular artery; and in 1 specimen (3%), the MMA shared a common branch with the inferior lateral genicular artery. The MMA was easily distinguishable from the superior, inferior, and middle genicular arteries, given its direct course to the medial joint line with terminal branches to the posterior horn of the medial meniscus and deep to the semimembranosus tendon. The MMA exhibited a consistently smaller vessel diameter relative to the genicular arteries.

Conclusion: This is the first study to identify and quantitatively describe the MMA in the human knee. The MMA can be identified consistently on gross anatomic dissection in cadaveric donors of varying demographics. Further research is needed to identify and characterize the artery in vivo and to determine the MMA's role in meniscus preservation surgery.

Clinical relevance: The findings of this study will provide future avenues of research toward understanding medial meniscus vascularization and the genesis of potential degenerative changes when vascularization is poor. This will help to further refine diagnostic and treatment options for meniscus revascularization and compartment preservation. Additionally, this study may help define safe zones in the knee during posterior approaches and expand the base of knowledge for emerging vascular procedures such as genicular artery embolization.

背景:Arnoczky 和 Warren 曾经描述过人体半月板的微血管。然而,迄今为止,内侧半月板关节外血管解剖的定性和定量研究尚未完成:对关节外内侧半月板血管进行定性和定量解剖研究,并引入新的 "内侧半月板动脉"(MMA),为未来治疗半月板异常提供指导:研究设计:描述性实验室研究:方法:解剖 33 个未配对的冷冻人体尸体膝关节。使用血管导管识别并插入股动脉。用红色丙烯酸涂料溶液灌注动脉,以提高可视度。使用数字卡尺测量动脉尺寸和距离。灌注标本使用计算机断层扫描成像,并使用三维重建软件进行分割,以识别血管并以数字方式重复动脉测量:结果:在所有标本中都能一致地识别出 MMA。在 33 个标本中,27 个标本(82%)的 MMA 直接从腘动脉分支;5 个标本(15%)的 MMA 与下内侧膝状动脉共用一条主干;1 个标本(3%)的 MMA 与下外侧膝状动脉共用一条分支。由于 MMA 直接通向内侧关节线,其末端分支通向内侧半月板后角和半膜肌腱深处,因此很容易与膝关节上动脉、膝关节下动脉和膝关节中动脉区分开来。与膝关节动脉相比,MMA 的血管直径一直较小:这是首次对人类膝关节中的 MMA 进行识别和定量描述的研究。在对不同人口统计学特征的尸体捐献者进行大体解剖时,可以一致地识别出 MMA。还需要进一步的研究来识别和描述体内动脉,并确定 MMA 在半月板保留手术中的作用:临床相关性:本研究的发现将为今后了解内侧半月板血管化以及血管化不良时潜在退行性病变的成因提供研究途径。这将有助于进一步完善半月板血管再通和隔间保留的诊断和治疗方案。此外,这项研究还有助于确定膝关节后路手术的安全区,并为膝关节动脉栓塞等新兴血管手术扩大知识基础。
{"title":"A Novel Description of Medial Meniscus Vascularization: A Multicenter Study Introducing the \"Medial Meniscal Artery\".","authors":"Robert Śmigielski, Eric Azua, Safa Gursoy, Zeeshan A Khan, Enzo S Mameri, Beata Ciszkowska-Łysoń, Bogdan Ciszek, Mario Hevesi, Jakub Piękoś, Aleksandra Zielińska, Bertram Zarins, Jorge Chahla","doi":"10.1177/03635465241291802","DOIUrl":"10.1177/03635465241291802","url":null,"abstract":"<p><strong>Background: </strong>The microvasculature of the human meniscus has been previously described by Arnoczky and Warren. However, to date, the qualitative and quantitative extra-articular vascular anatomy of the medial meniscus has not been characterized.</p><p><strong>Purposes: </strong>To perform a qualitative and quantitative anatomic study of the extra-articular medial meniscal vasculature and to introduce the novel \"medial meniscal artery\" (MMA), potentially providing future guidelines for the treatment of meniscal abnormalities.</p><p><strong>Study design: </strong>Descriptive laboratory study.</p><p><strong>Methods: </strong>A total of 33 unpaired, frozen human cadaveric knees were dissected. The femoral artery was identified and cannulated using an angiocatheter. The arteries were perfused with a red acrylic paint solution, allowing for improved visualization. Artery dimensions and distances were measured using a digital caliper. Perfused specimens were imaged using computed tomography and segmented using 3D reconstruction software to identify vessels and repeat artery measurements digitally.</p><p><strong>Results: </strong>The MMA was consistently identified in all specimens. In 27 (82%) of 33 specimens, the MMA branched directly from the popliteal artery; in 5 (15%), the MMA shared a common trunk with the inferior medial genicular artery; and in 1 specimen (3%), the MMA shared a common branch with the inferior lateral genicular artery. The MMA was easily distinguishable from the superior, inferior, and middle genicular arteries, given its direct course to the medial joint line with terminal branches to the posterior horn of the medial meniscus and deep to the semimembranosus tendon. The MMA exhibited a consistently smaller vessel diameter relative to the genicular arteries.</p><p><strong>Conclusion: </strong>This is the first study to identify and quantitatively describe the MMA in the human knee. The MMA can be identified consistently on gross anatomic dissection in cadaveric donors of varying demographics. Further research is needed to identify and characterize the artery in vivo and to determine the MMA's role in meniscus preservation surgery.</p><p><strong>Clinical relevance: </strong>The findings of this study will provide future avenues of research toward understanding medial meniscus vascularization and the genesis of potential degenerative changes when vascularization is poor. This will help to further refine diagnostic and treatment options for meniscus revascularization and compartment preservation. Additionally, this study may help define safe zones in the knee during posterior approaches and expand the base of knowledge for emerging vascular procedures such as genicular artery embolization.</p>","PeriodicalId":55528,"journal":{"name":"American Journal of Sports Medicine","volume":" ","pages":"3551-3560"},"PeriodicalIF":4.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Simple Clinical Predictive Model for Arthroscopic Mobility of Osteochondritis Dissecans Lesions of the Knee. 膝关节骨软骨炎失髁病变关节镜活动度的简单临床预测模型
IF 4.2 1区 医学 Q1 ORTHOPEDICS Pub Date : 2024-12-01 Epub Date: 2024-11-25 DOI: 10.1177/03635465241296133
Matthew D Milewski, Patricia E Miller, Emma C Gossman, Ryan P Coene, Marc A Tompkins, Christian N Anderson, Kathryn Bauer, Michael T Busch, James L Carey, Sasha Carsen, Henry G Chambers, Ryan P Coene, Eric W Edmonds, Jutta Ellermann, Henry B Ellis, John Erickson, Peter D Fabricant, Theodore J Ganley, Emma C Gossman, Daniel W Green, Benton E Heyworth, James Hoi Po Hui, Mininder S Kocher, Aaron J Krych, Kevin Latz, Roger M Lyon, Stephanie Mayer, Matthew D Milewski, Patricia E Miller, Bradley J Nelson, Jeffrey J Nepple, Jie C Nguyen, Carl W Nissen, James Lee Pace, Mark V Paterno, Andrew T Pennock, Crystal Perkins, John D Polousky, Paul Saluan, Kevin G Shea, Marc A Tompkins, Eric J Wall, Jennifer M Weiss, Clifton Willimon, Philip Wilson, Rick W Wright, Andy Zbojniewicz, Gregory D Myer

Background: Osteochondritis dissecans (OCD) of the knee is a focal idiopathic alteration of subchondral bone and/or its precursor with risk for instability and disruption of adjacent cartilage. Treatment options focused on preventing premature osteoarthritis vary depending on multiple patient and lesion characteristics, including lesion mobility.

Purpose: To differentiate lesion mobility before arthroscopy using a multivariable model that includes patient demographic characteristics and physical examination findings.

Study design: Cohort study (Diagnosis); Level of evidence, 2.

Methods: Demographic, preoperative physical examination, and radiographic data were collected from a multicenter national prospective cohort of patients with OCD of the knee. Inclusion criteria included patients <19 years of age and patients with arthroscopically confirmed mobility status based on the Research on Osteochondritis Dissecans of the Knee arthroscopy classification. Multivariable logistic regression analysis using stepwise model selection was used to determine factors associated with the likelihood of a mobile versus an immobile lesion. A 75% partition of the data was used for model training, and 25% was used as a validation cohort. Quantitative model fit statistics were computed using the holdout data, including sensitivity, specificity, and the area under the receiver operating characteristic curve (AUC), along with the corresponding 95% CI.

Results: A total of 407 patients in the prospective cohort met inclusion criteria, and 62% were male. The mean ± SD age was 13.7 ± 2.2 years, height 161.8 ± 5.3 cm, and weight 59.2 ± 42.2 kg. Arthroscopic evaluation yielded 235 immobile and 172 mobile lesions. Multivariable analysis determined that the best model to predict lesion mobility included chronologic age ≥14 years (P < .001), effusion on physical examination (P < .001), and any loss of range of motion on physical examination (P = .07), while controlling for male sex (P = .38) and weight >54.4 kg (P = .12). In the 25% holdout validation sample (n = 102), a sensitivity of 83%, a specificity of 82%, and an AUC of 0.89 (95% CI, 0.82-0.95) were achieved with these predictive factors.

Conclusion: Age, effusion, and loss of motion can predict knee OCD lesion mobility at the time of arthroscopy. Education about lesion mobility can help with surgical planning and patient and family counseling.

背景:膝关节骨软骨炎(Osteochondritis dissecans,OCD)是软骨下骨和/或其前体的局灶性特发性改变,具有不稳定性和破坏邻近软骨的风险。目的:使用包括患者人口统计学特征和体格检查结果在内的多变量模型,区分关节镜检查前的病变活动度:研究设计:队列研究(诊断);证据级别:2:从全国多中心前瞻性队列中收集膝关节OCD患者的人口统计学、术前体格检查和影像学数据。纳入标准包括患者前瞻性队列中共有 407 名患者符合纳入标准,其中 62% 为男性。平均年龄(13.7±2.2)岁,身高(161.8±5.3)厘米,体重(59.2±42.2)公斤。关节镜评估结果显示,不动病变为235例,活动病变为172例。多变量分析表明,预测病变活动度的最佳模型包括实际年龄≥14岁(P < .001)、体格检查有渗出(P < .001)和体格检查有任何活动范围减小(P = .07),同时控制男性性别(P = .38)和体重>54.4千克(P = .12)。在 25% 的保留验证样本(n = 102)中,这些预测因素的灵敏度为 83%,特异度为 82%,AUC 为 0.89(95% CI,0.82-0.95):结论:年龄、渗液和活动度丧失可预测关节镜检查时膝关节OCD病变的活动度。关于病变活动度的教育有助于手术规划和患者及家属咨询。
{"title":"A Simple Clinical Predictive Model for Arthroscopic Mobility of Osteochondritis Dissecans Lesions of the Knee.","authors":"Matthew D Milewski, Patricia E Miller, Emma C Gossman, Ryan P Coene, Marc A Tompkins, Christian N Anderson, Kathryn Bauer, Michael T Busch, James L Carey, Sasha Carsen, Henry G Chambers, Ryan P Coene, Eric W Edmonds, Jutta Ellermann, Henry B Ellis, John Erickson, Peter D Fabricant, Theodore J Ganley, Emma C Gossman, Daniel W Green, Benton E Heyworth, James Hoi Po Hui, Mininder S Kocher, Aaron J Krych, Kevin Latz, Roger M Lyon, Stephanie Mayer, Matthew D Milewski, Patricia E Miller, Bradley J Nelson, Jeffrey J Nepple, Jie C Nguyen, Carl W Nissen, James Lee Pace, Mark V Paterno, Andrew T Pennock, Crystal Perkins, John D Polousky, Paul Saluan, Kevin G Shea, Marc A Tompkins, Eric J Wall, Jennifer M Weiss, Clifton Willimon, Philip Wilson, Rick W Wright, Andy Zbojniewicz, Gregory D Myer","doi":"10.1177/03635465241296133","DOIUrl":"10.1177/03635465241296133","url":null,"abstract":"<p><strong>Background: </strong>Osteochondritis dissecans (OCD) of the knee is a focal idiopathic alteration of subchondral bone and/or its precursor with risk for instability and disruption of adjacent cartilage. Treatment options focused on preventing premature osteoarthritis vary depending on multiple patient and lesion characteristics, including lesion mobility.</p><p><strong>Purpose: </strong>To differentiate lesion mobility before arthroscopy using a multivariable model that includes patient demographic characteristics and physical examination findings.</p><p><strong>Study design: </strong>Cohort study (Diagnosis); Level of evidence, 2.</p><p><strong>Methods: </strong>Demographic, preoperative physical examination, and radiographic data were collected from a multicenter national prospective cohort of patients with OCD of the knee. Inclusion criteria included patients <19 years of age and patients with arthroscopically confirmed mobility status based on the Research on Osteochondritis Dissecans of the Knee arthroscopy classification. Multivariable logistic regression analysis using stepwise model selection was used to determine factors associated with the likelihood of a mobile versus an immobile lesion. A 75% partition of the data was used for model training, and 25% was used as a validation cohort. Quantitative model fit statistics were computed using the holdout data, including sensitivity, specificity, and the area under the receiver operating characteristic curve (AUC), along with the corresponding 95% CI.</p><p><strong>Results: </strong>A total of 407 patients in the prospective cohort met inclusion criteria, and 62% were male. The mean ± SD age was 13.7 ± 2.2 years, height 161.8 ± 5.3 cm, and weight 59.2 ± 42.2 kg. Arthroscopic evaluation yielded 235 immobile and 172 mobile lesions. Multivariable analysis determined that the best model to predict lesion mobility included chronologic age ≥14 years (<i>P</i> < .001), effusion on physical examination (<i>P</i> < .001), and any loss of range of motion on physical examination (<i>P</i> = .07), while controlling for male sex (<i>P</i> = .38) and weight >54.4 kg (<i>P</i> = .12). In the 25% holdout validation sample (n = 102), a sensitivity of 83%, a specificity of 82%, and an AUC of 0.89 (95% CI, 0.82-0.95) were achieved with these predictive factors.</p><p><strong>Conclusion: </strong>Age, effusion, and loss of motion can predict knee OCD lesion mobility at the time of arthroscopy. Education about lesion mobility can help with surgical planning and patient and family counseling.</p>","PeriodicalId":55528,"journal":{"name":"American Journal of Sports Medicine","volume":" ","pages":"3543-3550"},"PeriodicalIF":4.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High Variability of Lateral Extra-articular Tenodesis Femoral Tunnel Position With Landmark-Based Techniques. 基于地标技术的外侧关节外腱鞘股骨隧道位置的高变异性
IF 4.2 1区 医学 Q1 ORTHOPEDICS Pub Date : 2024-12-01 Epub Date: 2024-11-20 DOI: 10.1177/03635465241289417
Ajay C Kanakamedala, Bradley M Kruckeberg, Olivia M Jochl, Ryan J Whalen, Mark E Cinque, Thomas R Hackett, Jonathan A Godin, Armando F Vidal

Background: The utilization of lateral extra-articular tenodesis (LET) augmentation for anterior cruciate ligament reconstruction has increased. Various fixation points have been recommended based on tactile and anatomic landmarks; however, there is limited reporting of the accuracy or precision of these techniques in clinical practice.

Purpose/hypothesis: The purpose of this study was to evaluate whether LET fixation points identified using anatomic landmarks and tactile techniques would fall within a predefined radiographic zone. It was hypothesized that the majority of LET fixation points would be inside the radiographic zone.

Study design: Cross-sectional study; Level of evidence, 4.

Methods: Postoperative lateral knee radiographs of patients who underwent anterior cruciate ligament reconstruction with LET using a landmark-based technique without fluoroscopy between January 2018 and September 2023 were reviewed. Fixation points were measured by 2 raters based on their distance from an extension of the posterior femoral cortex line (PFCL) distally and a line perpendicular to the PFCL at the posterior condylar flare (PCF). Patients were excluded if the tunnel position could not be identified or if postoperative radiographs were malrotated. The mean LET position and percentage of points within the radiographic isometric zone, defined as 4 ± 4 mm posterior and 4 ± 3 mm anterior to the PFCL and 6 ± 4 mm distal and 20 ± 5 mm proximal to the PCF were calculated.

Results: Complete data sets were obtained for 47 cases. The mean LET position was 6.4 ± 7.1 mm (range, -9 to 27.3 mm) anterior to the PFCL and 1.8 ± 7.6 mm (range, -16.7 to 12.6 mm) proximal to the PCF. Overall, 53% of LET fixation points were within the predefined radiographic zone. Of the malpositioned tunnels (n = 22), their locations relative to the radiographic zone were anterior (n = 18), posterior (n = 2), proximal (n = 1), and anterior and distal (n = 1).

Conclusion: This study found large variation in the location of LET fixation points, and almost half of fixation points were outside the predefined radiographic zone. Accurate and precise tunnel placement is one of multiple factors that may be important to minimize the risk of lateral compartment overconstraint, anterior cruciate ligament graft failure, and anisometry leading to LET graft loosening.

背景:在前十字韧带重建中使用外侧关节外韧带增强术(LET)的情况越来越多。根据触觉和解剖标志推荐了各种固定点;然而,关于这些技术在临床实践中的准确性或精确性的报道却很有限:本研究的目的是评估使用解剖标志和触觉技术确定的 LET 固定点是否位于预定义的放射区域内。假设大多数 LET 固定点都在放射成像区域内:研究设计:横断面研究;证据级别:4:回顾了2018年1月至2023年9月期间使用基于地标的技术在无透视的情况下进行LET前交叉韧带重建的患者的术后膝关节侧位X光片。由两名评分员根据股骨后皮质线(PFCL)远端延长线和髁后外翻(PCF)处垂直于 PFCL 的线的距离测量固定点。如果无法确定隧道位置或术后X光片显示转位不良,则排除患者。计算了 LET 位置的平均值和在影像学等距区内的点的百分比,等距区的定义为 PFCL 后方 4 ± 4 mm,前方 4 ± 3 mm,PCF 远端 6 ± 4 mm,近端 20 ± 5 mm:获得了 47 个病例的完整数据集。平均 LET 位置为 PFCL 前方 6.4 ± 7.1 mm(范围为 -9 至 27.3 mm),PCF 近端 1.8 ± 7.6 mm(范围为 -16.7 至 12.6 mm)。总体而言,53% 的 LET 固定点位于预定义的放射区域内。在位置不正的隧道(22 个)中,其相对于放射区的位置分别为前方(18 个)、后方(2 个)、近端(1 个)以及前方和远端(1 个):本研究发现,LET 固定点的位置差异很大,近一半的固定点位于预定义的放射学区域之外。准确和精确的隧道位置是将侧室过度收缩、前交叉韧带移植失败以及导致LET移植松动的异常测量风险降至最低的多个重要因素之一。
{"title":"High Variability of Lateral Extra-articular Tenodesis Femoral Tunnel Position With Landmark-Based Techniques.","authors":"Ajay C Kanakamedala, Bradley M Kruckeberg, Olivia M Jochl, Ryan J Whalen, Mark E Cinque, Thomas R Hackett, Jonathan A Godin, Armando F Vidal","doi":"10.1177/03635465241289417","DOIUrl":"10.1177/03635465241289417","url":null,"abstract":"<p><strong>Background: </strong>The utilization of lateral extra-articular tenodesis (LET) augmentation for anterior cruciate ligament reconstruction has increased. Various fixation points have been recommended based on tactile and anatomic landmarks; however, there is limited reporting of the accuracy or precision of these techniques in clinical practice.</p><p><strong>Purpose/hypothesis: </strong>The purpose of this study was to evaluate whether LET fixation points identified using anatomic landmarks and tactile techniques would fall within a predefined radiographic zone. It was hypothesized that the majority of LET fixation points would be inside the radiographic zone.</p><p><strong>Study design: </strong>Cross-sectional study; Level of evidence, 4.</p><p><strong>Methods: </strong>Postoperative lateral knee radiographs of patients who underwent anterior cruciate ligament reconstruction with LET using a landmark-based technique without fluoroscopy between January 2018 and September 2023 were reviewed. Fixation points were measured by 2 raters based on their distance from an extension of the posterior femoral cortex line (PFCL) distally and a line perpendicular to the PFCL at the posterior condylar flare (PCF). Patients were excluded if the tunnel position could not be identified or if postoperative radiographs were malrotated. The mean LET position and percentage of points within the radiographic isometric zone, defined as 4 ± 4 mm posterior and 4 ± 3 mm anterior to the PFCL and 6 ± 4 mm distal and 20 ± 5 mm proximal to the PCF were calculated.</p><p><strong>Results: </strong>Complete data sets were obtained for 47 cases. The mean LET position was 6.4 ± 7.1 mm (range, -9 to 27.3 mm) anterior to the PFCL and 1.8 ± 7.6 mm (range, -16.7 to 12.6 mm) proximal to the PCF. Overall, 53% of LET fixation points were within the predefined radiographic zone. Of the malpositioned tunnels (n = 22), their locations relative to the radiographic zone were anterior (n = 18), posterior (n = 2), proximal (n = 1), and anterior and distal (n = 1).</p><p><strong>Conclusion: </strong>This study found large variation in the location of LET fixation points, and almost half of fixation points were outside the predefined radiographic zone. Accurate and precise tunnel placement is one of multiple factors that may be important to minimize the risk of lateral compartment overconstraint, anterior cruciate ligament graft failure, and anisometry leading to LET graft loosening.</p>","PeriodicalId":55528,"journal":{"name":"American Journal of Sports Medicine","volume":" ","pages":"3569-3577"},"PeriodicalIF":4.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Patient Resilience on Functional Outcomes After Anterior Cruciate Ligament Reconstruction. 患者复原力对前交叉韧带重建术后功能效果的影响
IF 4.2 1区 医学 Q1 ORTHOPEDICS Pub Date : 2024-12-01 Epub Date: 2024-11-14 DOI: 10.1177/03635465241293726
Adeeb Jacob Hanna, Gaston Davis, Rahul Muchintala, Alice He, Sean Bryan, Fotios P Tjoumakaris, Kevin B Freedman

Background: Previous studies have examined the relationship between patient resilience and functional outcome scores after anterior cruciate ligament reconstruction (ACLR). However, past studies have failed to explore the longitudinal relationship between preoperative resilience and functional outcomes 2 years after ACLR.

Purpose: To evaluate the relationship between preoperative patient resilience and functional outcomes 2 years after ACLR.

Study design: Cohort study; Level of evidence, 3.

Methods: Patients were identified who underwent ACLR for anterior cruciate ligament tears between January and June 2020 at a single institution. Those who completed the Brief Resilience Scale preoperatively as part of routine patient questionnaires were considered for inclusion. Patients were contacted a minimum of 2 years after ACLR to complete the short form of the Knee injury and Osteoarthritis Outcome Score (KOOS-JR), Single Assessment Numeric Evaluation (SANE), International Knee Documentation Committee (IKDC) Subjective Knee Form, and visual analog scale (VAS). Outcomes were compared among patients with low resilience (LR), normal resilience (NR), and high resilience (HR), as defined in a previous study.23.

Results: A total of 81 patients were included in the final analysis, with 14 patients in the low preoperative resilience group, 54 in normal, and 13 in high. The mean age of the cohort was 32.0 years, and there were no significant differences in age, sex, race, graft type, or psychiatric comorbidities among the resilience groups. Significantly increased postoperative KOOS-JR scores were observed in patients in the HR group as compared with those in the NR and LR groups (94.8, 86.7, and 79.6, respectively; P = .031). There were also significantly increased postoperative SANE scores in patients in the HR group versus those in the NR and LR groups (92.3, 83.5, and 69.2; P = .012). Patients with high preoperative resilience achieved the IKDC Patient Acceptable Symptom State at significantly higher rates (P = .003). No significant differences were observed in postoperative VAS (P = .364), IKDC (P = .072), or change in IKDC (P = .448) over time among resilience groups. Postoperatively, 30 patients (37.0%) changed resilience groups, with 13 moving down and 17 moving up in category (low, n = 12; normal, n = 55; high, n = 14).

Conclusion: Preoperative resilience correlated with KOOS-JR and SANE scores 2 years after ACLR but did not correlate with VAS, IKDC, or change in IKDC over the same period. Resilience was not static, with changes in resilience observed from initial to final evaluations. Resilience is not a strong predictor of postoperative patient-reported outcomes after ACLR.

背景:以往的研究探讨了患者复原力与前交叉韧带重建术(ACLR)后功能结果评分之间的关系。目的:评估患者术前恢复力与前交叉韧带重建术后 2 年功能结果之间的关系:研究设计:队列研究;证据级别:3:研究对象为 2020 年 1 月至 6 月期间在一家医疗机构接受前交叉韧带撕裂 ACLR 的患者。作为常规患者调查问卷的一部分,术前填写了简明复原力量表的患者被考虑纳入研究范围。在 ACLR 术后至少 2 年与患者联系,让他们完成膝关节损伤和骨关节炎结果评分 (KOOS-JR) 简表、单次数字评估 (SANE)、国际膝关节文献委员会 (IKDC) 主观膝关节表格和视觉模拟量表 (VAS)。根据之前研究的定义,比较了低复原力(LR)、正常复原力(NR)和高复原力(HR)患者的治疗效果:共有 81 名患者被纳入最终分析,其中术前复原力低的患者有 14 人,复原力正常的有 54 人,复原力高的有 13 人。组群的平均年龄为 32.0 岁,各复原力组在年龄、性别、种族、移植类型或精神疾病方面没有显著差异。与NR组和LR组相比,HR组患者术后KOOS-JR评分显著增加(分别为94.8、86.7和79.6;P = .031)。与 NR 组和 LR 组相比,HR 组患者的术后 SANE 评分也明显提高(分别为 92.3、83.5 和 69.2;P = .012)。术前复原力高的患者达到 IKDC 患者可接受症状状态的比例明显更高(P = .003)。术后 VAS(P = .364)、IKDC(P = .072)或 IKDC 随时间的变化(P = .448)在复原力组别中未观察到明显差异。术后,30 名患者(37.0%)改变了复原力组别,其中 13 名患者的组别下降,17 名患者的组别上升(低,n = 12;正常,n = 55;高,n = 14):结论:术前恢复力与前交叉韧带置换术后2年的KOOS-JR和SANE评分相关,但与VAS、IKDC或同期IKDC的变化无关。复原力并非一成不变,从最初评估到最终评估,复原力都在发生变化。复原力并不是 ACLR 术后患者报告结果的有力预测因素。
{"title":"Effect of Patient Resilience on Functional Outcomes After Anterior Cruciate Ligament Reconstruction.","authors":"Adeeb Jacob Hanna, Gaston Davis, Rahul Muchintala, Alice He, Sean Bryan, Fotios P Tjoumakaris, Kevin B Freedman","doi":"10.1177/03635465241293726","DOIUrl":"10.1177/03635465241293726","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have examined the relationship between patient resilience and functional outcome scores after anterior cruciate ligament reconstruction (ACLR). However, past studies have failed to explore the longitudinal relationship between preoperative resilience and functional outcomes 2 years after ACLR.</p><p><strong>Purpose: </strong>To evaluate the relationship between preoperative patient resilience and functional outcomes 2 years after ACLR.</p><p><strong>Study design: </strong>Cohort study; Level of evidence, 3.</p><p><strong>Methods: </strong>Patients were identified who underwent ACLR for anterior cruciate ligament tears between January and June 2020 at a single institution. Those who completed the Brief Resilience Scale preoperatively as part of routine patient questionnaires were considered for inclusion. Patients were contacted a minimum of 2 years after ACLR to complete the short form of the Knee injury and Osteoarthritis Outcome Score (KOOS-JR), Single Assessment Numeric Evaluation (SANE), International Knee Documentation Committee (IKDC) Subjective Knee Form, and visual analog scale (VAS). Outcomes were compared among patients with low resilience (LR), normal resilience (NR), and high resilience (HR), as defined in a previous study.<sup>23</sup>.</p><p><strong>Results: </strong>A total of 81 patients were included in the final analysis, with 14 patients in the low preoperative resilience group, 54 in normal, and 13 in high. The mean age of the cohort was 32.0 years, and there were no significant differences in age, sex, race, graft type, or psychiatric comorbidities among the resilience groups. Significantly increased postoperative KOOS-JR scores were observed in patients in the HR group as compared with those in the NR and LR groups (94.8, 86.7, and 79.6, respectively; <i>P</i> = .031). There were also significantly increased postoperative SANE scores in patients in the HR group versus those in the NR and LR groups (92.3, 83.5, and 69.2; <i>P</i> = .012). Patients with high preoperative resilience achieved the IKDC Patient Acceptable Symptom State at significantly higher rates (<i>P</i> = .003). No significant differences were observed in postoperative VAS (<i>P</i> = .364), IKDC (<i>P</i> = .072), or change in IKDC (<i>P</i> = .448) over time among resilience groups. Postoperatively, 30 patients (37.0%) changed resilience groups, with 13 moving down and 17 moving up in category (low, n = 12; normal, n = 55; high, n = 14).</p><p><strong>Conclusion: </strong>Preoperative resilience correlated with KOOS-JR and SANE scores 2 years after ACLR but did not correlate with VAS, IKDC, or change in IKDC over the same period. Resilience was not static, with changes in resilience observed from initial to final evaluations. Resilience is not a strong predictor of postoperative patient-reported outcomes after ACLR.</p>","PeriodicalId":55528,"journal":{"name":"American Journal of Sports Medicine","volume":" ","pages":"3595-3601"},"PeriodicalIF":4.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment and Early Outcomes of Capitellar Osteochondritis Dissecans. 髌骨软骨炎脱落症的治疗和早期疗效。
IF 4.2 1区 医学 Q1 ORTHOPEDICS Pub Date : 2024-12-01 Epub Date: 2024-11-15 DOI: 10.1177/03635465241289939
Evan T Zheng, Koya Osada, Kathryn A Williams, Donald S Bae

Background: Treatment for osteochondritis dissecans (OCD) of the humeral capitellum has been predominantly guided by fragment stability and articular cartilage integrity. Nonoperative management is recommended for stable lesions, whereas surgical intervention is indicated for unstable lesions and those that fail nonoperative care. Several surgical options may be considered, although limited information is available regarding indications for specific surgical techniques and comparative postoperative results.

Purpose: To assess surgical outcomes of patients with capitellar OCD treated according to a decision-making approach focused on subchondral bone involvement.

Study design: Cohort study; Level of evidence, 3.

Methods: Patients diagnosed with capitellar OCD at a tertiary academic center were enrolled in a prospective longitudinal cohort study. Patient information was collected at the time of enrollment, and OCD lesions were classified according to the Nelson grade. Clinical and radiologic data were collected both pre- and postoperatively for those undergoing surgical treatment. Surgical procedures were performed based on an evolving treatment framework that included considerations specifically for lesion containment and depth of subchondral bone disease. Timmerman scores were obtained to assess patient functional outcomes.

Results: A total of 154 patients were prospectively enrolled, 19 of whom had bilateral disease. The mean age at presentation was 13.7 years; 39% were gymnasts and 28.5% were primary baseball or softball athletes. Surgery was performed on 145 elbows, including 43 drilling/microfracture procedures, 21 internal fixations, and 63 autologous osteochondral grafting (OG) procedures. Clinically, there were significant improvements in pain, elbow motion, and mechanical symptoms. Timmerman scores significantly improved after each type of surgical procedure. A total of 76% of patients returned to their primary sport. When stratified by the Nelson grade, patients with OG had lower revision surgery rates than those treated with drilling/microfracture and fixation. Furthermore, for Nelson grade 2 lesions, patients treated with OG had significantly better postoperative elbow motion and higher Timmerman scores compared with those treated with other procedures.

Conclusion: Using a treatment framework incorporating lesion containment and depth of subchondral bone disease, surgery for capitellar OCD provides clinical, radiologic, and functional improvements. Patients treated with OG may have lower revision rates and better functional outcomes compared with those treated with other surgical techniques, with OG warranting consideration even for lower-grade OCD lesions.

背景:肱骨岬骨软骨炎(OCD)的治疗主要以骨片稳定性和关节软骨完整性为指导。对于稳定的病变建议采用非手术治疗,而对于不稳定的病变和非手术治疗无效的病变则应进行手术治疗。目的:评估根据软骨下骨受累的决策方法治疗帽状腱膜 OCD 患者的手术效果:研究设计:队列研究;证据级别:3.方法:诊断为帽状腱膜强迫症的患者进行手术治疗:一项前瞻性纵向队列研究纳入了在一家三级学术中心确诊的帽状腱膜强迫症患者。入组时收集患者信息,并根据纳尔逊分级对OCD病变进行分类。对接受手术治疗的患者收集了术前和术后的临床和放射学数据。外科手术是根据不断发展的治疗框架进行的,其中包括对病变控制和软骨下骨病深度的具体考虑。通过Timmerman评分来评估患者的功能效果:共有154名患者接受了前瞻性治疗,其中19人患有双侧疾病。患者的平均年龄为13.7岁,39%为体操运动员,28.5%为棒球或垒球运动员。对145名患者的肘部进行了手术,包括43例钻孔/微骨折手术、21例内固定手术和63例自体骨软骨移植(OG)手术。在临床上,疼痛、肘关节活动度和机械症状均有明显改善。每种手术治疗后,Timmerman评分都有明显改善。共有76%的患者恢复了主要运动。根据纳尔逊分级进行分层后,OG患者的翻修手术率低于钻孔/微骨折和固定治疗的患者。此外,对于纳尔逊2级病变,与采用其他治疗方法的患者相比,采用OG治疗的患者术后肘关节活动度明显更好,Timmerman评分也更高:结论:通过结合病变控制和软骨下骨病变深度的治疗框架,手术治疗帽状腱膜OCD可改善临床、放射学和功能。与采用其他手术技术治疗的患者相比,采用OG治疗的患者翻修率更低,功能效果更好,即使是低级别OCD病变也值得考虑OG。
{"title":"Treatment and Early Outcomes of Capitellar Osteochondritis Dissecans.","authors":"Evan T Zheng, Koya Osada, Kathryn A Williams, Donald S Bae","doi":"10.1177/03635465241289939","DOIUrl":"10.1177/03635465241289939","url":null,"abstract":"<p><strong>Background: </strong>Treatment for osteochondritis dissecans (OCD) of the humeral capitellum has been predominantly guided by fragment stability and articular cartilage integrity. Nonoperative management is recommended for stable lesions, whereas surgical intervention is indicated for unstable lesions and those that fail nonoperative care. Several surgical options may be considered, although limited information is available regarding indications for specific surgical techniques and comparative postoperative results.</p><p><strong>Purpose: </strong>To assess surgical outcomes of patients with capitellar OCD treated according to a decision-making approach focused on subchondral bone involvement.</p><p><strong>Study design: </strong>Cohort study; Level of evidence, 3.</p><p><strong>Methods: </strong>Patients diagnosed with capitellar OCD at a tertiary academic center were enrolled in a prospective longitudinal cohort study. Patient information was collected at the time of enrollment, and OCD lesions were classified according to the Nelson grade. Clinical and radiologic data were collected both pre- and postoperatively for those undergoing surgical treatment. Surgical procedures were performed based on an evolving treatment framework that included considerations specifically for lesion containment and depth of subchondral bone disease. Timmerman scores were obtained to assess patient functional outcomes.</p><p><strong>Results: </strong>A total of 154 patients were prospectively enrolled, 19 of whom had bilateral disease. The mean age at presentation was 13.7 years; 39% were gymnasts and 28.5% were primary baseball or softball athletes. Surgery was performed on 145 elbows, including 43 drilling/microfracture procedures, 21 internal fixations, and 63 autologous osteochondral grafting (OG) procedures. Clinically, there were significant improvements in pain, elbow motion, and mechanical symptoms. Timmerman scores significantly improved after each type of surgical procedure. A total of 76% of patients returned to their primary sport. When stratified by the Nelson grade, patients with OG had lower revision surgery rates than those treated with drilling/microfracture and fixation. Furthermore, for Nelson grade 2 lesions, patients treated with OG had significantly better postoperative elbow motion and higher Timmerman scores compared with those treated with other procedures.</p><p><strong>Conclusion: </strong>Using a treatment framework incorporating lesion containment and depth of subchondral bone disease, surgery for capitellar OCD provides clinical, radiologic, and functional improvements. Patients treated with OG may have lower revision rates and better functional outcomes compared with those treated with other surgical techniques, with OG warranting consideration even for lower-grade OCD lesions.</p>","PeriodicalId":55528,"journal":{"name":"American Journal of Sports Medicine","volume":" ","pages":"3466-3472"},"PeriodicalIF":4.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
American Journal of Sports Medicine
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1