American Journal of Geriatric Psychiatry最新文献

{"title":"The Association of Life’s Crucial 9, Socioeconomic Status, and Social Isolation With Dementia","authors":"Jiao-Jiao Ren Ph.D. ,&nbsp;Shu-Fei Wu M.P.A. ,&nbsp;Wen-Fang Zhong M.D. ,&nbsp;Jian Gao M.D. ,&nbsp;Wei-Qi Song M.D. ,&nbsp;Chen Mao Ph.D.","doi":"10.1016/j.jagp.2025.11.003","DOIUrl":"10.1016/j.jagp.2025.11.003","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the association between Life’s Crucial 9 (LC9) and dementia, and the mediating and interaction effects of socioeconomic status or social isolation with LC9, as well as their joint association on dementia.</div></div><div><h3>Methods</h3><div>LC9 included diet, physical activity, body mass index, sleep duration, tobacco exposure, blood lipids, blood pressure, blood glucose, and psychological health. Socioeconomic status was derived from education, income, and employment status. Social isolation was based on household cohabitants, friend/family visit frequency, and weekly social activities. Cox proportional hazard models were performed to estimate the association of LC9 with dementia.</div></div><div><h3>Results</h3><div>Our analysis included 336,394 UK Biobank individuals. Compared with high LC9 category, the hazard ratio (95% confidence interval) with low LC9 category was 2.12 (1.72–2.62) for all-cause dementia. The association between LC9 and dementia was partially mediated by socioeconomic status or social isolation. A significant additive interaction was observed between LC9 and socioeconomic status on all-cause dementia (p &lt;0.05). Participants with low LC9 category, low socioeconomic status and social isolation had the highest risk of dementia compared with those with high LC9 category, high socioeconomic status and no social isolation (HR: 3.35, 95% CI: 2.79–4.01).</div></div><div><h3>Conclusions</h3><div>The low LC9 category was associated with a higher risk of dementia, and socioeconomic status or social isolation mediated a small proportion of this association. These results feature the importance of preserving an ideal LC9 as a potential prevention approach for dementia and emphasize the benefits of simultaneous and comprehensive intervention strategies in decreasing dementia risk.</div></div>","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 2","pages":"Pages 199-209"},"PeriodicalIF":3.8,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145644831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Stress on All-Cause Dementia: A Longitudinal Analysis From the Australian Longitudinal Study on Women’s Health","authors":"Kay Khaing M.Med. ,&nbsp;Xenia Dolja-Gore Ph.D. ,&nbsp;Balakrishnan R. Nair M.D. ,&nbsp;Julie Byles Ph.D. ,&nbsp;John Attia Ph.D.","doi":"10.1016/j.jagp.2025.11.005","DOIUrl":"10.1016/j.jagp.2025.11.005","url":null,"abstract":"<div><h3>Objectives</h3><div>Perceived stress has been linked to dementia, however the duration of perceived stress, as well as the timing of this exposure, on dementia has not been explored. This study aimed to assess the effect of transient versus prolonged versus persistent perceived stress and exposure to stressful life events (SLE), as well as time windows of exposure, on all-cause dementia.</div></div><div><h3>Design</h3><div>Cohort study.</div></div><div><h3>Setting</h3><div>The Australian Longitudinal Study on Women’s Health (ALSWH).</div></div><div><h3>Participants</h3><div>The oldest cohort (born 1921–26), and the middle cohort (born 1946–51), from the Australian Longitudinal Study on Women’s Health were used in this analysis.</div></div><div><h3>Measures</h3><div>Perceived stress and SLE were measured using a self-reported questionnaire. Dementia was defined as per International Classification of Disease – 10 (ICD 10) codes through linked datasets over a mean follow up of 16 years for the oldest and 20 years for the middle cohort.</div></div><div><h3>Results</h3><div>Transient, prolonged and persistent perceived stress were associated with increased risk of all-cause dementia (HR: 1.52, 95% CI: 1.04–2.23, HR: 1.63, 95% CI: 1.15–2.27, and HR: 1.65, 95% CI: 1.10–2.50 respectively) in the middle cohort. Higher risk of all-cause dementia was found among middle cohort exposed to four or more SLE, however the association was statistically insignificant in the fully adjusted model. Both perceived stress and SLE had no effect in the oldest cohort.</div></div><div><h3>Conclusion</h3><div>Transient, prolonged and persistent perceived stress were associated with higher risk of all-cause dementia in our middle cohort which suggests that stress may be a risk factor for dementia.</div></div>","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 3","pages":"Pages 269-280"},"PeriodicalIF":3.8,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145650814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Mental Health More Difficult to Improve Than Physical Function?","authors":"Steven M. Albert Ph.D.","doi":"10.1016/j.jagp.2025.11.004","DOIUrl":"10.1016/j.jagp.2025.11.004","url":null,"abstract":"","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 2","pages":"Pages 162-163"},"PeriodicalIF":3.8,"publicationDate":"2025-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145644834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring Apathy Through Computational Lenses: Behavioral and Physiological Signatures of Engagement in Virtual Reality","authors":"Daniel Harlev M.D. ,&nbsp;Ramit Ravona Springer M.D. ,&nbsp;Meir Plotnik Ph.D.,&nbsp;Noham Wolpe M.D., Ph.D.","doi":"10.1016/j.jagp.2025.10.012","DOIUrl":"10.1016/j.jagp.2025.10.012","url":null,"abstract":"","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 2","pages":"Pages 256-257"},"PeriodicalIF":3.8,"publicationDate":"2025-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145598324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioral and Physiological Signatures of Engagement in Virtual Reality: Comment","authors":"Hinpetch Daungsupawong PhD ,&nbsp;Viroj Wiwanitkit MD","doi":"10.1016/j.jagp.2025.11.001","DOIUrl":"10.1016/j.jagp.2025.11.001","url":null,"abstract":"","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 2","pages":"Pages 254-255"},"PeriodicalIF":3.8,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145592632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain Amyloid and Cognitive Decline in Late-Life Depression","authors":"Nunzio Pomara M.D.,&nbsp;Chelsea Reichert Plaska Ph.D.,&nbsp;Bruno Pietro Imbimbo Ph.D.","doi":"10.1016/j.jagp.2025.10.009","DOIUrl":"10.1016/j.jagp.2025.10.009","url":null,"abstract":"","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 2","pages":"Pages 262-263"},"PeriodicalIF":3.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145575195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to “Brain Amyloid and Cognitive Decline in Late-Life Depression”","authors":"Emma Rhodes Ph.D. ,&nbsp;Philip S. Insel Ph.D. ,&nbsp;Michelle Kassel Ph.D. ,&nbsp;Maria Kryza-Lacombe Ph.D. ,&nbsp;Meryl A. Butters Ph.D. ,&nbsp;David Bickford M.D. ,&nbsp;Duygu Tosun Ph.D. ,&nbsp;Ruth Morin Ph.D. ,&nbsp;Paul Aisen M.D. ,&nbsp;Howie Rosen M.D. ,&nbsp;Rema Raman Ph.D. ,&nbsp;Susan Landau Ph.D. ,&nbsp;Andrew Saykin Psy.D. ,&nbsp;Arthur W. Toga Ph.D. ,&nbsp;Clifford R. Jack M.D. ,&nbsp;Michael W. Weiner M.D. ,&nbsp;Craig Nelson M.D. ,&nbsp;R. Scott Mackin Ph.D.","doi":"10.1016/j.jagp.2025.10.010","DOIUrl":"10.1016/j.jagp.2025.10.010","url":null,"abstract":"","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 2","pages":"Pages 258-261"},"PeriodicalIF":3.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145644827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Psychoeducational and Exercise Training Intervention to Improve Mental Health and Physical Functioning in Late-Life: A Randomized Controlled Trial","authors":"Margarita Alegria Ph.D. ,&nbsp;Walter Frontera M.D., Ph.D ,&nbsp;Mario Cruz-Gonzalez Ph.D. ,&nbsp;Sheri Markle M.I.A. ,&nbsp;Aida Jimenez Ph.D. ,&nbsp;Zorangeli Ramos Ph.D. ,&nbsp;Taysha Bruno-Ortiz Ph.D. ,&nbsp;Larimar Fuentes Ph.D. ,&nbsp;Megan Cheung M.S.W. ,&nbsp;Yankau Josephine Wong Ph.D. ,&nbsp;Irene Falgas-Bague M.D., Ph.D. ,&nbsp;Patrick E Shrout Ph.D.","doi":"10.1016/j.jagp.2025.10.006","DOIUrl":"10.1016/j.jagp.2025.10.006","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the effectiveness of an enhanced psychoeducational and exercise training intervention (Positive Minds Strong Bodies-Enhanced [PMSB-E]) on depression and anxiety symptoms and physical functioning.</div></div><div><h3>Design</h3><div>Randomized trial of 427 participants, assigned to intervention or usual care.</div></div><div><h3>Setting</h3><div>51 community-based organizations and 17 clinics in Massachusetts, New York, Puerto Rico, and Maryland, US. Data collected from November 2020 to October 2024, at baseline and months 3, 6, and 12.</div></div><div><h3>Participants</h3><div>Adults aged 60+ or older with mild to severe depression or anxiety symptoms, minor to moderate mobility limitations, and fluency in English, Spanish, Mandarin, or Cantonese.</div></div><div><h3>Interventions</h3><div>Ten psychoeducational and 36 exercise sessions over 6 months compared to usual care (one-on-one phase; 1:1 ratio). Half of the intervention participants were offered an additional 6-month group maintenance phase (1:1 ratio). Control participants received up to 4 usual care calls.</div></div><div><h3>Measurements</h3><div>Primary outcome was change from baseline to month 12 in depression and anxiety symptoms (Hopkins Symptom Checklist-25 [HSCL-25]) and physical functioning (Short Physical Performance Battery [SPPB] and Late-Life Functioning and Disability Instrument [LLFDI]). Secondary outcome was change in month 6.</div></div><div><h3>Results</h3><div>Intervention participants showed improved SPPB scores in month 12 (standardized difference, 0.28; 95% CI, 0.07–0.49) and month 6 (0.34; 95% CI, 0.14–0.55). There were no effects on LLFDI or HSCL-25 scores, nor interaction effects by race and ethnicity. Completing the recommended number of sessions had a larger effect on SPPB scores.</div></div><div><h3>Conclusions</h3><div>PMSB-E replicated previous findings of improving objective physical functioning but not self-reported physical functioning or mental health symptoms. We believe this is due to virtual administration during the pandemic.</div></div>","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 2","pages":"Pages 147-161"},"PeriodicalIF":3.8,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145558873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Silencing of Science is a Call for Communications","authors":"Joseph K. Balintfy BA","doi":"10.1016/j.jagp.2025.10.007","DOIUrl":"10.1016/j.jagp.2025.10.007","url":null,"abstract":"","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 1","pages":"Pages 123-126"},"PeriodicalIF":3.8,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145566964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authorial Integrity in the Age of Artificial Intelligence: A Scientific Autobiography","authors":"Christopher C. Colenda M.D., M.P.H.","doi":"10.1016/j.jagp.2025.10.004","DOIUrl":"10.1016/j.jagp.2025.10.004","url":null,"abstract":"<div><div>Writing a scientific autobiography is challenging due to the many factors influencing an academic career, including personal experiences, the era of one’s career, research interests, available research tools, institutional environment, societal priorities, and mentorship. Despite changing contexts, certain obligations remain constant: scholars have an obligation to prioritize scientific and personal integrity above the pursuit of individual success, and they must ethically use research tools, including information technology search processes and writing technologies, as part of their scientific processes. The first obligation is built on personal integrity, which in turn characterizes how the second is implemented. My career spanned the last quarter of the 20th century through the first quarter of the 21st century. During this period, there were significant advancements in research methodologies, including the capability of internet search technologies to access scientific databases and desktop writing and referencing software. These advances pale in comparison to the meteoric rise of artificial intelligence large language models (AI LLMs) over the last 5 years, where information retrieval and writing tools have transformed how we access and use information – potentially placing our personal and authorial integrity at risk. Given this rapid transformation, my autobiography’s objectives are: 1) to share my developmental perspectives on personal and authorial integrity and examine the impact of early experiences where perceived plagiarism helped me define those principles; 2) to review professional guidelines concerning research integrity and policy recommendations for AI LLMs; 3) to discuss changes in my scholarly content resulting from evolving search strategies, writing tools, and journal growth; and 4) by using examples of AI-generated and AI-assisted writing samples, to address the influence of AI LLMs on authorial integrity, including practical risks, opportunities, and current recommended strategies for managing AI LLMs in scholarly writing. By sharing my perspectives, I hope to provide guidance for those pursuing scholarly careers that ensures their authorial integrity.</div></div>","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 2","pages":"Pages 235-244"},"PeriodicalIF":3.8,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145524988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}