American Journal of Geriatric Psychiatry最新文献

{"title":"Commentary: The Effect of Stress on All-Cause Dementia: A Longitudinal Analysis from the Australian Longitudinal Study on Women’s Health","authors":"Robert H. Pietrzak Ph.D., M.P.H. , Peter J. Na M.D., M.P.H. , Yen Ying Lim Ph.D.","doi":"10.1016/j.jagp.2025.12.001","DOIUrl":"10.1016/j.jagp.2025.12.001","url":null,"abstract":"","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 3","pages":"Pages 281-283"},"PeriodicalIF":3.8,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145852203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Music Listening as a Low-Risk Adjunct to Delirium Prevention: Translating Evidence to the Ward","authors":"Chenlei Sun Ph.D. , Ke Meng Ph.D. , Xiaomeng Zhu Ph.D.","doi":"10.1016/j.jagp.2025.11.020","DOIUrl":"10.1016/j.jagp.2025.11.020","url":null,"abstract":"","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 3","pages":"Pages 397-398"},"PeriodicalIF":3.8,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145937368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which Type of Group Activity has the Greatest Impact on the Well-Being of Persons With Dementia? An Exploration of a Study of Enhanced Group Activity Kits","authors":"Jiska Cohen-Mansfield Ph.D.","doi":"10.1016/j.jagp.2025.12.003","DOIUrl":"10.1016/j.jagp.2025.12.003","url":null,"abstract":"<div><h3>Objectives</h3><div>Group activities for persons living with dementia (PLwD) can enhance their well-being, mental health, and affect; however, little is known about how activity type influences outcomes. This study examines the relative impact of activity type on well-being within the context of Enhanced Group Activity Kits (EGAKs).</div></div><div><h3>Design</h3><div>This is a secondary analysis of a stepped wedge clustered trial introducing EGAKs sequentially across settings.</div></div><div><h3>Settings</h3><div>Six nursing care units and four senior day center units in Israel.</div></div><div><h3>Participants</h3><div>One hundred fifteen PLwD who resided in or attended these settings.</div></div><div><h3>Intervention</h3><div>Forty seven EGAK-facilitated group activities in eight categories, including singing, creative arts, reading and discussion, and travel around the world, led by staff members.</div></div><div><h3>Measurements</h3><div>Research observers and activity leaders independently rated participants’ responses via the group observational measurement of engagement, from which the well-being index was derived. Mixed models analyses compared well-being across categories and within categories, controlling for participants’ cognitive function.</div></div><div><h3>Results</h3><div>All 47 EGAKs yielded maximum well-being scores for at least one participant. Significant differences emerged across categories: physical exercise, creative arts, singing, and Jewish texts reading/discussion achieved the highest well-being, whereas travel around the world and art history elicited the lowest. Within-category analyses showed significant variations within six of the eight categories. Correspondingly, the ranking of mean well-being for some kits diverged from others within their category.</div></div><div><h3>Conclusions</h3><div>While certain categories consistently promoted well-being, effectiveness depended on activity characteristics, such as personal relevance and cognitive accessibility. These findings suggest that tailoring activity content and delivery may be more important than activity type in enhancing well-being for PLwD.</div></div>","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 3","pages":"Pages 337-347"},"PeriodicalIF":3.8,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145968321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lost and Found: A 78th Birthday Meditation","authors":"David L. Coulter M.D.","doi":"10.1016/j.jagp.2025.08.009","DOIUrl":"10.1016/j.jagp.2025.08.009","url":null,"abstract":"","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 1","pages":"Pages 144-145"},"PeriodicalIF":3.8,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information for Subscribers","authors":"","doi":"10.1016/S1064-7481(25)00514-7","DOIUrl":"10.1016/S1064-7481(25)00514-7","url":null,"abstract":"","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 1","pages":"Page A1"},"PeriodicalIF":3.8,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145594787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Substance use disorders in later life: a review and synthesis of the literature of an emerging public health concern” Am J Geriatr Psychiatry, 2020, 28(2): 226–236","authors":"Stephanie Yarnell M.D., Ph.D ,&nbsp;Luming Li M.D., M.H.S. ,&nbsp;Brian MacGrory MB BCh BAO, M.H.S., MRCP ,&nbsp;Louis Trevisan M.D. ,&nbsp;Paul Kirwin M.D.","doi":"10.1016/j.jagp.2025.11.012","DOIUrl":"10.1016/j.jagp.2025.11.012","url":null,"abstract":"","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 2","pages":"Page 267"},"PeriodicalIF":3.8,"publicationDate":"2025-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145752457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reflections on a Study of Low-Dose Agomelatine as Add-on for Agitation in Alzheimer’s Disease","authors":"Sumedha Saha M.B.B.S.,&nbsp;Skarma Spalzang M.D.,&nbsp;Susanta Kumar Padhy M.D.,&nbsp;Arpit Parmar M.D., D.M.","doi":"10.1016/j.jagp.2025.11.011","DOIUrl":"10.1016/j.jagp.2025.11.011","url":null,"abstract":"","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 3","pages":"Pages 405-406"},"PeriodicalIF":3.8,"publicationDate":"2025-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145759377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain, Body, and Equity: A Pathway to Healthy Aging","authors":"Hanadi Ajam Oughli M.D.,&nbsp;Helen Lavretsky M.D., M.S.","doi":"10.1016/j.jagp.2025.11.008","DOIUrl":"10.1016/j.jagp.2025.11.008","url":null,"abstract":"","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 2","pages":"Pages 164-166"},"PeriodicalIF":3.8,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145717195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dronabinol for Agitation in Alzheimer’s Disease","authors":"Rajesh R. Tampi M.D., M.S., D.F.A.P.A., D.F.A.A.G.P.","doi":"10.1016/j.jagp.2025.11.006","DOIUrl":"10.1016/j.jagp.2025.11.006","url":null,"abstract":"","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 2","pages":"Pages 180-182"},"PeriodicalIF":3.8,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145688918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomized Controlled Trial of the Safety and Efficacy of Dronabinol for Agitation in Alzheimer’s Disease","authors":"Paul B. Rosenberg M.D. ,&nbsp;Halima Amjad M.D., M.P.H., Ph.D. ,&nbsp;Haroon Burhanullah M.D. ,&nbsp;Milap Nowrangi M.D. ,&nbsp;Ryan Vandrey Ph.D. ,&nbsp;Mersania Jn Pierre B.A. ,&nbsp;John D. Outen M.S. ,&nbsp;Meghan Schultz R.N., M.S.N ,&nbsp;Christopher Marano M.D. ,&nbsp;Marc Agronin M.D. ,&nbsp;James M. Wilkins M.D., D.Phil. ,&nbsp;David Harper Ph.D. ,&nbsp;Todd Laffaye B.A. ,&nbsp;Eilis Reardon B.A. ,&nbsp;Kathryn Turner B.A. ,&nbsp;Rosain Ozonsi B.S. ,&nbsp;Mia Drury B.A. ,&nbsp;Andre Nguyen B.S. ,&nbsp;Tuna Hasoğlu M.D. ,&nbsp;Julia Cromwell M.D. ,&nbsp;Brent P. Forester M.D., M.Sc.","doi":"10.1016/j.jagp.2025.10.011","DOIUrl":"10.1016/j.jagp.2025.10.011","url":null,"abstract":"<div><h3>Importance</h3><div>Agitation in Alzheimer’s disease (AD) is a great source of distress for patients and caregivers and a major public health burden. Current treatments are only modestly effective and many have safety issues including mortality risk. Novel therapeutic options are needed. There is preliminary evidence for the safety and efficacy of dronabinol (tetrahydrocannabinol, THC) for agitation in AD.</div></div><div><h3>Objective</h3><div>Assess the safety and efficacy of dronabinol (THC) to decrease agitation in AD.</div></div><div><h3>Design</h3><div>THC-AD was a 3-week randomized parallel double-blind placebo-controlled clinical trial, conducted between 2017 and 2024.</div></div><div><h3>Setting</h3><div>5 inpatient and outpatient academic clinical research centers in the Eastern U.S.</div></div><div><h3>Participants</h3><div>Volunteer sample of 75 participants meeting inclusion criteria for agitation of AD (International Psychogeriatric Association Provision Criteria) with Neuropsychiatric Inventory Clinician Version Agitation or Aggression (NPI-C A/A) domains total score of 4 or greater. Major exclusion criteria included seizure disorder, delirium, and non-AD dementia.</div></div><div><h3>Interventions</h3><div>3 weeks dronabinol vs. placebo titrated up to target dose of 10 mg daily in divided twice-daily.</div></div><div><h3>Main Outcomes and Measures</h3><div>Prespecified co-primary agitation outcomes were the Pittsburgh Agitation Scale (PAS) and NPI-C A/A total score.</div></div><div><h3>Results</h3><div>The majority of participants were female and were taking concomitant psychotropic medications (antidepressants and antipsychotics) at baseline. Study participants were moderately agitated at baseline, were diverse in ethnic background (9% Black, 11% Hispanic/Latina/Latino), and had severe cognitive impairment evidenced by MMSE or SIB-8. 84% completed the 3-week trial. Dronabinol decreased agitation on both primary outcomes greater than placebo to a clinically relevant extent. The fitted between-arm difference in PAS decline/week was −0.74 (SE 0.3, p = 0.015, effect size = 0.53) and for NPI-C A/A the decline was not significant at −1.26 (SE 0.67, p = 0.094, effect size = 0.36). No secondary outcomes differed between treatment arms including sleep, activities of daily living, Cohen-Mansfield Agitation Inventory (CMAI), cognition, intoxication, or use of ‘as-needed’ lorazepam or trazodone. Dronabinol treatment was not associated with greater intoxication nor with other adverse events (AEs) except for somnolence.</div></div><div><h3>Conclusions and Relevance</h3><div>Adjunctive dronabinol treatment was safe and effective for treating agitation in AD.</div></div><div><h3>Clinical Trials Registration</h3><div>NCT02792257</div></div>","PeriodicalId":55534,"journal":{"name":"American Journal of Geriatric Psychiatry","volume":"34 2","pages":"Pages 167-179"},"PeriodicalIF":3.8,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145688911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}