Aging Male最新文献

Background: The link between obstructive sleep apnea (OSA) and serum testosterone levels is still unclear.

Method: This cross-sectional study analyzed data from the 2015-2016 NHANES cycle and an independent polysomnography (PSG) cohort (validation cohort). We examined associations between OSA severity and risks of testosterone deficiency. Additionally, we quantified the capacity of BOADAI and apnea-hypopnea index to assess testosterone deficiency in OSA patients.

Results: The study included 2,359 participants from the NHANES cohort and 172 from the standardized PSG cohort. A negative correlation was identified between OSA and serum testosterone levels. After multivariable adjustment, OSA patients exhibited a 31% increased risk of testosterone deficiency (odds ratio [OR] = 1.31, 95% confidence interval [CI]: (1.02, 1.70), p = 0.03). This risk escalated to 67% in severe OSA (OR = 1.67, 95% CI: (1.04-2.68), p = 0.03) versus controls. The BOADAI showed stronger inverse correlation with testosterone(r = -0.37) and remained independently associated with testosterone deficiency (OR = 2.37, 95% CI:(1.12-5.32), p = 0.01).

Conclusions: This study provided evidence of a negative association between OSA and serum testosterone levels. The BOADAI, measurable at home via a finger-clip oximeter, provides an effective and more convenient monitoring alternative for monitoring testosterone levels in OSA management.

Objective: Peyronie's disease and hypogonadism are believed to have a linear association; however, research has yielded conflicting results. This is the first histopathological study on this topic.

Methodology: This study randomly assigned 40 three-month-old male Sprague-Dawley rats to five groups. We established Peyronie's model by injecting intratunical TGF-beta and 3% disodium phosphate dihydrate into four groups. One group received intratunical saline. The control group for the Peyronie's disease model was one group. In the other groups, the first had castration orchiectomy. The second group was the Peyronie's disease model control. The third group received intratunical saline injections. The fourth group received intraperitoneal testosterone injections, while the fifth received 0.5 mg of 5-alpha reductase inhibitor orally daily. We excised penile tissue for histopathology after a 30-day follow-up. Masson's trichrome staining found collagen and smooth muscle, picro-sirius staining found collagen III and collagen I, and hematoxylin and eosin staining found fibrosis.

Results: Histopathological examination revealed significant differences in fibrosis, smooth muscle/collagen ratios, and collagen III/collagen I ratios. Comparing groupings without a control group revealed no statistically significant differences.

Conclusion: This study explored testosterone's effect on Peyronie's disease in rats. Fibrosis was analyzed, but no significant changes were observed.

Objective: To evaluate the causal relationship between air pollution and erectile dysfunction (ED).

Methods: This study was evaluated by the method of double sample Mendelian random grouping (MR). The exposure data were from the GWAS data set of British biological bank (n = 461). Results the data were integrated into three cohorts (223805 healthy controls and 6175 ED patients). Inverse variance weighted (IVW) analysis was mainly used, supplemented by Mr egger regression, weighted median and Cochran's Q test. One analysis was reserved for quality control, and Bonferroni correction was used for multiple tests.

Results: The increase of PM2.5 predicted by gene was significantly correlated with the increased risk of ED (IVW or = 1.65, 95% CI = 1.12 - 2.43, P = 0.010), which was still significant after Bonferroni correction (p < 1.67 × 10^-2) After adjusting for confounding factors, multivariate MR analysis confirmed that PM2.5 had an independent causal effect on ed. Mr egger regression showed no horizontal pleiotropy (intercept P > 0.05), and no heterogeneity or abnormal single nucleotide polymorphisms were found.

Conclusion: This is the first genetic evidence that PM2.5 is an independent risk factor for ED. it is emphasized that air pollution control is the key public health strategy for global ed prevention.

Background: Exercise prescription can promote the rehabilitation of patients with prostate cancer (PCa). However, the effect of exercise intervention onserum levels of prostate-specific antigen (PSA) and testosterone remains unclear.

Methods: The primary outcome was the effect of exercise prescription on PSA level. The secondary outcome was the effect of exercise training on testosterone level. The pooled standardized mean difference (SMD) with 95% confidence interval (CI) was selected as the indicator. Meta-regression was conducted to assess the relationship between covariates and outcomes. Publication bias was evaluated using funnel plots and Egger's test.

Results: The data of 594 patients from 8 randomized controlled trials (RCTs) were included and analyzed. Pooled effect of exercise intervention on PSA was 0.13 (95% CI: -0.04 to 0.29, I² = 0.0%, p = 0.984), while the pooled effect on testosterone was 0.19 (95% CI: -0.00 to 0.39, I² = 0.0%, p = 0.435). The meta-regression showed there was no significant association of age, body mass index, and the exercise duration with PSA or testosterone. No significant publication bias was detected in meta-analysis.

Conclusions: Although many benefits were documented, exercise intervention have no significant effect on PSA and testosterone levels in PCa patients.

Background: Clinical observational studies have demonstrated a high prevalence of obstructive sleep apnea (OSA) in patients with atrial fibrillation (AF), indicating a significant comorbidity between the two conditions. This study applies transcriptome data to investigate shared molecular mechanisms underlying AF and OSA comorbidity and develops a robust diagnostic model to evaluate OSA risk in AF patients.

Methods: Transcriptomic datasets for AF (GSE79768) and OSA (GSE135917) were retrieved from the the Gene Expression Omnibus(GEO) database. Differentially expressed genes (DEGs) associated with OSA and AF comorbidity were identified using weighted gene co-expression network analysis (WGCNA). Protein-protein interaction (PPI) networks were constructed using Cytoscape, and hub genes were identified with the CytoHubba plug-in. A diagnostic model was then built based on these hub genes, and its performance was evaluated using receiver operating characteristic (ROC) curves in both the test and validation datasets. Immune cell infiltration analysis was conducted using CIBERSORT.

Results: A total of 1,462 differentially expressed genes (DEGs) were identified for the comorbidity of AF and OSA. Five hub genes were selected: IFNG, IL4, IL15, CD19, and FASLG. Immunoassay infiltration analysis revealed elevated levels of activated macrophages in both OSA and AF samples. The diagnostic model we developed demonstrated excellent predictive performance in the validation set.

Conclusion: We identified five hub genes common to both OSA and AF: IFNG, IL4, IL15, CD19, and FASLG. Moreover, a diagnostic model based on these five hub genes can predict the risk of OSA in patients with AF.

Background: In the elderly, diagnosing and treating functional dyspepsia may be more challenging. The objectives of the study were to evaluate the prevalence and association of functional dyspepsia in adult individuals and elderly populations (especially ≥64 years) in the year 2024-2025 literature available.

Methods: The study included a search of electronic articles, electronic books, and electronic book chapters using the keywords "dyspepsia" and "age" in PubMed, PubMed Central, and Google.

Results: A total of 27.5 ± 21.39%, 24.8 ± 21.86%, 23.83 ± 23.54%, 23.5 ± 25.06%, and 21.9 ± 24.63% are reported prevalence of dyspepsia in all study populations (1-100 years; 23 articles), for patients ≥50 years (20 articles), for patients >55 years (15 articles), for patients ≥64 years (15 articles), and for patients >70 years (12 articles), respectively. Mostly gastric symptoms, specific treatments, older age, and female gender were associated with functional dyspepsia.

Conclusions: One in four individuals in every age group has functional dyspepsia among the included patients (25% of patients). The study reported a 23.5 ± 25.06% prevalence of functional dyspepsia for ≥64 years patients regardless of the definition used. Helicobacter pylori infection, specific treatments, female gender, poorer sleep quality, and smoking are independent factors for the prevalence of functional dyspepsia in ≥64 years patients.

Background: Testosterone deficiency (TD) is a prevalent condition that negatively impacts health, with diet quality being a potential modifiable risk factor. Using cross-sectional NHANES 2011-2016 data, we evaluated the association between diet quality and TD.

Methods: This cross-sectional study analyzed 3262 male adults aged ≥20 years from NHANES (2011-2016). Diet quality was assessed using the Healthy Eating Index (HEI-2020) and the Comprehensive Dietary Antioxidant Index (CDAI). Logistic regression analysis was performed to assess the association between diet quality and TD.

Results: Participants with TD had significantly lower HEI-2020 scores compared to non-TD participants (48.64 vs. 49.38, p = 0.038). In the fully adjusted model (age, race, BMI, etc.), participants in the highest tertile of CDAI had a significantly lower risk of TD (OR = 0.85, 95% CI: 0.76-0.96, p = 0.014). After adjusting for potential confounders (age, race, BMI, etc.), individuals in the highest tertile of HEI-2020 also showed a reduced odds of TD (OR = 0.87, 95% CI: 0.77-0.98, p = 0.011).

Conclusions: Better adherence to diet quality indices, as measured by HEI-2020 and CDAI, is associated with a lower risk of TD.

Purpose: This study evaluates the effectiveness of artificial urinary sphincter (AUS) implantation following transperineal reanastomosis in men with vesicourethral anastomotic stenosis (VUAS) and stress urinary incontinence (SUI) after radical prostatectomy (RP), focusing on long-term explantation rates and urinary continence.

Methods: Patients treated between 2009 and 2020 were retrospectively analyzed. Those undergoing AUS implantation post-transperineal reanastomosis for recurrent VUAS, excluding cases with prior pelvic irradiation and overactive bladder, were included. Primary outcomes were AUS explantation rates and patient-reported continence. Median follow-up was calculated using reverse Kaplan-Meier estimates, and explantation-free survival illustrated via Kaplan-Meier analyses.

Results: At final follow-up, 19 patients were included at a median follow-up of 79 months. Explantation occurred in 16% (N = 3) of cases, with a median time to explantation of 107 months. No urethral erosion was observed. Explantation-free survival at 2, 5, and 10 years was 100%, 87%, and 73%, respectively. The median number of pads/day decreased significantly postoperatively, with 78% (N = 14) reporting subjective continence and 89% (N = 16) achieving social continence.

Conclusion: AUS implantation following transperineal reanastomosis for VUAS post-RP offers favorable long-term outcomes, with low explantation rates and no erosion, making it a viable management strategy.