Aging Male最新文献

Purpose: This study investigated the causal effect of 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) on erectile dysfunction (ED) and elucidated its underlying molecular mechanisms through multi-omics integration.

Methods: Mendelian randomization (MR) was applied to evaluate the causal effects of CMPF on ED and metabolic risk factors. Network pharmacology was used to identify overlapping molecular targets, followed by molecular docking to assess binding affinity. Multi-omics validation incorporated Summary-data-based MR (SMR) analyses of expression and protein quantitative trait loci (eQTL/pQTL) to confirm genetically regulated CMPF-related targets.

Results: MR analyses demonstrated a protective effect of CMPF on ED in both discovery (OR: 0.78, 95% CI: 0.62-0.98) and replication cohorts (OR: 0.82, 95% CI: 0.69-0.98), along with favorable associations with glucose metabolism, blood pressure, and lipid traits. Network analysis identified 42 shared targets, with DPP4, LGALS3, and NR3C2 as hub targets. Molecular docking showed strong binding affinities (≤-6.0 kcal/mol). SMR analyses highlighted LGALS3 as a key genetic mediator, supported by consistent eQTL and pQTL signals.

Conclusions: CMPF exerts protective effects against ED and metabolic dysfunction through multi-target modulation, with LGALS3, DPP4, and NR3C2 as central regulators. These findings support CMPF as a diet-derived bioactive metabolite with potential for nutritional interventions and multi-target therapeutic strategies in ED.

Background: The ZJU index is a composite metric incorporating triglyceride (TG), fasting plasma glucose (FPG), the alanine aminotransferase (ALT) to aspartate aminotransferase ratio (AST) (ALT/AST), and body mass index (BMI). This study aimed to investigate the relationship between the ZJU index and the risk of erectile dysfunction (ED).

Methods: This analysis utilized data from 1,906 participants in the 2001-2004 National Health and Nutrition Examination Survey (NHANES) dataset. We employed logistic regression modeling, smooth curve fitting, subgroup analysis, and threshold effect analysis to evaluate the association between the ZJU index and ED. The missing values in the covariates were filled by multiple interpolation.

Results: A significant positive association was observed between the ZJU index and ED risk (OR [95% CI] = 1.03 [1.01,1.05]). Analysis revealed a threshold at a ZJU index of 33.4, above which ED risk increased markedly, while the association was not significant below this value. Subgroup analysis indicated a stronger association in participants under 60 years of age.

Conclusion: Higher ZJU index values are positively associated with an increased risk of erectile dysfunction, particularly among individuals under 60 years old. These findings suggest the potential utility of the ZJU index as a screening tool for ED risk assessment.

Background: Prostate cancer (PC) is a common malignancy in older adults. We aimed to construct a nomogram for the overall survival (OS) of elderly patients with locally advanced PC who received radiotherapy and surgery.

Methods: Clinical and pathological information was downloaded from the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2015. The selected patients were randomly divided into a training cohort and a validation cohort at a ratio of 7:3. Univariate, multivariate Cox, and stepwise backward regression analyses were used to identify independent risk factors for OS.

Results: A total of 2810 elderly patients with locally advanced PC who received radiotherapy and surgery from 2010 to 2015 were included in this study. Age, marital status, Gleason score, tumor stage were identified as independent risk factors for PC patients. Age and marital status primarily reflect background mortality risk. The nomogram demonstrated favorable discrimination and calibration, with AUCs of 0.676-0.774 for 3-, 5-, and 8-year OS, indicating good predictive performance. Decision curve analysis further confirmed its superior clinical net benefit compared with the traditional tumor-node-metastasis staging model.

Conclusions: We developed a new nomogram to predict OS in elderly patients with locally advanced PC treated with radiotherapy and surgery.

Objective: This study sought to delineate a putative synergistic interplay between vitamin D and testosterone and their conjoint associations with sexual function and quality of life in men presenting with symptoms of hypogonadism.

Methods: A retrospective cohort analysis was performed in men attending the andrological clinic of the University Hospital Münster (Germany) between 2016 and 2021. Individuals exhibited complete biochemical, clinical, and questionnaire datasets. Endocrine parameters, validated psychometric instruments, and demographic variables were systematically evaluated.

Results: Among 5,324 screened men, 2,059 fulfilled inclusion criteria (mean age 43.9 years). The cohort displayed a pronounced symptom burden (mitigated wellbeing and erectile function). 25-hydroxyvitamin D and testosterone concentrations resided predominantly within suboptimal ranges. Both vitamin D and testosterone correlated inversely with BMI and AMS scores, and positively with IIEF-EF scores (all p < 0.001). Effect size analyses and multiples regressions indicated a robust dependency of symptom severity on vitamin D as well as testosterone status across somatic, sexual, and metabolic indices, underscoring an interdependent relationship between vitamin D and testosterone in shaping sexual function and well-being.

Conclusion: Albeit causality cannot be inferred, this analysis highlights a clinical convergence of vitamin D and testosterone in modulating sexual health and quality of life in men.

Background: Understanding aging men's perspective on functional ability is of utmost importance to tailor the delivery of medical care and to inform policy makers about aging men's primary health concerns.

Methods: The purpose of this analysis was to describe trends in self-perceived physical and mental health problems causing functional limitations in US men aged ≥60 years based on National Health and Nutrition Examination Surveys data from 2011 to 2018.

Results: Data from 2,494 males with a mean age of 68.56 years was analyzed. Participants reported a median number of 1 health problem causing functional limitations. With 20.54% and 17.75%, respectively, arthritis/rheumatism and back/neck problems emerged as the main problems. The predicted prevalence of arthritis/rheumatism causing functional limitations increased significantly from 2011-2012 to 2017-2018 by 9% (p = 0.028). Back/neck problems increased by 10% from 2011-2012 to 2015-2016 (p = 0.004). The predicted number of health problems causing functional difficulties was 1.81 times higher in those aged ≥80 years when compared to those aged 60 years (p < 0.001).

Conclusions: Health conditions which attract higher attention from a public health point of view (e.g. cardiovascular disease or metabolic disorders) are less frequently reported among aging men when it comes to functional disabilities and physical functioning.

Background: To investigate the associations between various patterns of physical activity (PA) and risk of hip fracture in Chinese middle-aged and older adults.

Methods: Data were obtained from the China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2020. PA levels, including moderate-to-vigorous (MVPA), vigorous (VPA), moderate (MPA), low (LPA), and total physical activity (TPA), were assessed using the International Physical Activity Questionnaire. Cox proportional hazard models were used to estimate hazard ratios (HRs), and a restricted cubic spline analyzed the dose-response relationship between TPA and hip fracture.

Results: Among 6,193 participants (mean age 59.3; 54.0% female), 264 hip fractures occurred during follow-up. Meeting WHO-recommended MVPA levels ≥150 min/week) was not associated with reduced risk (HR 1.04, 95% CI 0.80-1.35). Similarly, no significant associations were observed for VPA (≥75 min/week), MPA (≥150 min/week), LPA (≥300 min/week), or TPA (≥600 MET-min/week). Dose-response analysis also showed no association between total PA and hip fracture.

Conclusion: This study does not support the WHO recommendation of ≥ 150 min/week of MVPA for reducing hip fracture risk in this demographic. As PA was self-reported and largely work-related, future research should investigate leisure-time and objectively-measured PA.

Background: The association between hypertension and kidney stones remains inconsistent. This research investigated the relationship between hypertension and the risk and progression of kidney stones.

Methods: A cross-sectional analysis was performed using data from the National Health and Nutrition Examination Survey (NHANES). The association was assessed with a multivariable logistic regression model. Furthermore, a two-sample Mendelian randomization (MR) analysis was conducted to evaluate causality. Methods included inverse-variance weighted (IVW), weighted median, and sensitivity analyses. Summary-level data for kidney stones were obtained from the UK Biobank, and for hypertension from a genome-wide association study (GWAS)analysis.

Results: The NHANES analysis included 21,740 participants. After full adjustment, hypertension was significantly associated with a higher prevalence of kidney stones (odds ratio [OR] = 1.36, 95% confidence interval [CI]: 1.19-1.56, p < 0.001). In the MR analysis, the IVW method indicated a causal effect of hypertension on kidney stones (OR = 1.01, 95% CI: 1.00-1.01, p = 0.013), supported by the weighted median method (OR = 1.01, 95% CI: 1.00-1.02, p = 0.002). Sensitivity analyses revealed no significant heterogeneity or pleiotropy.

Conclusions: Our investigation revealed a heightened risk of kidney stones linked to hypertension, which necessitates validation through further large-scale prospective cohort studies.

Background: The Charlson Comorbidity Index (CCI) quantifies multimorbidity, but its link to erectile dysfunction (ED) remains underexplored.

Methods: Using data from the National Health and Nutrition Examination Survey (NHANES), our study investigated the association between CCI and ED. Our analysis involved weighted multivariate regression, subgroup analyses, restricted cubic spline (RCS) analyses, and propensity score matching (PSM) analyses.

Results: Among the 2295 adults included in this study, 863 (37.6%) were diagnosed with ED. Weighted multivariate regression analyses revealed a significant positive association between the CCI and the risk of ED. Each additional point on the CCI was associated with a 32% higher risk of ED (OR 1.32, 95% CI 1.18-1.47). Furthermore, when participants were categorized into two groups based on CCI scores (CCI = 0 and CCI ≥ 1), the risk of ED was notably higher for those with CCI ≥ 1, showing a 122% increased risk compared to those with CCI = 0 (OR 2.22, 95% CI 1.62-3.05). Sensitivity analyses, including subgroup analyses and PSM, consistently supported the strong positive correlation between the CCI and ED.

Conclusion: Our study indicates that a higher CCI is positively correlated with an increased risk of ED, suggesting that lower CCI scores are associated with lower risk of ED.

Background: The current study aimed to explore the potential associations between Phenotypic Age (PhenoAge)/PhenoAge acceleration (PhenoAgeAccel) and erectile dysfunction (ED).

Methods: We carried out a cross-sectional study based on data from 2360 male participants from the National Health and Nutrition Examination Survey program in the year 2001-2004. ED was evaluated according to a self-administered questionnaire. PhenoAge and PhenoAgeAccel were employed to evaluate the biological aging speed as previously reported. Weighted logistic regression analyses were performed to reveal the association between either PhenoAge or PhenoAgeAccel and ED. We also applied restricted cubic spline (RCS) models to explore the non-linearity in such associations. Sensitivity analyses were performed to detect the robustness of the main finding.

Results: Significantly higher PhenoAge and PhenoAgeAccel were observed in participants with ED compared with no ED group (both p < 0.0001). Multivariate logistic analyses exhibited significant associations of both PhenoAge and PhenoAgeAccel, either in continuous or categorical forms, with ED, with comprehensive adjustment. RCS models revealed the non-linear relationship between either PhenoAge or PhenoAgeAccel and ED. Sensitivity analyses showed the associations between PhenoAge/PhenoAgeAccel and ED remained significant.

Conclusions: Our results suggested a significantly positive association between either PhenoAge or PhenoAgeAccel and ED. Future researches are needed to verify our findings.