Aging Male最新文献

Aims: Epidemiological studies indicate a heightened risk of pancreatic adenocarcinoma (PAAD) in patients with type 2 diabetes mellitus (T2DM). This study investigates the molecular mechanisms underlying their comorbidity.

Materials and methods: Common DEGs between T2DM and PAAD were identified from GEO datasets. Functional and pathway enrichment analyses were performed via PPI, GO, and KEGG. Core genes were screened and their diagnostic value was validated by ROC curves. Immune infiltration and TF-mRNA-miRNA regulatory networks were constructed to explore disease mechanisms. Core gene expression and prognostic significance in PAAD were assessed using GEPIA2 and HPA. Potential therapeutics targeting core genes were predicted via the Therapeutic Target Database.

Results: A total of 35 DEGs were identified. GO analysis linked these genes to cell adhesion and extracellular matrix (ECM) components. KEGG enrichment highlighted ECM-receptor interaction as the top pathway. Key ECM-related molecules-ITGA3, FN1, LAMB3, ITGA2, and LAMC2-were upregulated in both T2DM and PAAD. Six potential therapeutic agents targeting ITGA2, LAMB3, and FN1 were identified.

Conclusion: Three genes and associated known drugs identified in this study may serve as potential targets for treating the coexistence of the two diseases.

Objectives: This study aimed to elucidate the correlation of Visceral Adiposity Index (VAI) with prostate cancer (PCa) among men aged 40 years and older in the United States.

Methods: Analysis included multivariate linear and logistic regression, smoothing curve fitting, and threshold effect evaluation using 2003-2010 National Health and Nutrition Examination Survey (NHANES) data. The stability of this relationship across demographic groups was assessed via subgroup analyses and interaction tests.

Results: Among 2,768 participants, those with elevated VAI displayed lower total prostate-specific antigen (tPSA) levels and reduced PCa risk. Each VAI unit elevation corresponded to a 0.075 ng/mL tPSA reduction [-0.075 (-0.145, -0.005)] and 18.8% PCa risk reduction [0.812 (0.687, 0.960)]. Top-quartile VAI individuals exhibited 0.282 ng/mL reduced tPSA [-0.282 (-0.557, -0.007)] and 49.7% reduced PCa risk [0.503 (0.282, 0.896)] relative to bottom-quartile counterparts. This inverse relationship was more pronounced in men ≥70 years. Moreover, VAI-tPSA in other races demonstrated a U-shaped pattern, with a 2.09 inflection point. At the same time, a Mexican American subgroup exhibited an inverted U-shape for VAI and PCa risk, with a 1.42 inflection point.

Conclusion: In men aged ≥70, VAI indicates an inverse PCa relationship. However, PSA-based PCa screening may be influenced in visceral-obese individuals aged <70.

Background: Benign prostatic hyperplasia (BPH) is a common condition that affects elderly men, but its relationship with central obesity in the American population has not been adequately elucidated.

Methods: In this study, we included a total of 4,625 participants from the National Health and Nutrition Examination Survey (NHANES) database spanning from 2001 to 2008. We calculated indices related to central obesity for each participant and then employed univariate logistic regression, multivariate logistic regression, restricted cubic splines (RCS), and Akaike's Information Criterion (AIC) analysis.

Results: we found that the indices of Weight, Waist Circumference (WC), waist-to-Height Ratio (WHtR), and Body Roundness Index (BRI) were significantly elevated in the BPH group. In terms of dietary intake, we found that the intake of total fat, saturated fatty acids, monounsaturated fatty acids, polyunsaturated fatty acids, and cholesterol was significantly higher in the BPH group, with polyunsaturated fatty acids and cholesterol meeting the criteria for both univariate and multivariate regression analyses.

Conclusion: Weight, WC, WHtR, and BRI can effectively improve the prediction of BPH, which may be associated with the high intake of polyunsaturated fatty acids and cholesterol. Appropriately adjusting the types and total amount of fat intake may prevent the occurrence of prostatic hyperplasia.

Background: The association between preventive aspirin use and urinary incontinence (UI) among male adults remains poorly understand.

Methods: In this study, we analyzed data from the National Health and Nutrition Examination Survey (NHANES) collected in the 2011 ∼ 2018 cycle among US male adults, with aspirin use was defined as individuals self-reported use of aspirin. Multi-variable adjusted logistic regression models were used to analysis the association between aspirin use and UI.

Results: A total of 6844 male participants were evaluated in the study. Compared to participants without aspirin use, the individuals on aspirin with or without coronary heart disease (CVD), respectively, had higher incidences of urinary dysfunction including UI, urgent micturition, and nocturia. In addition, in multivariable logistic adjusted models, the risk of UI (OR = 2.44; 95%CI = 2.10-2.83; P-value = 0.0000) and urgent micturition (OR = 1.57; 95% CI = 1.35-1.83; P-value = 0.0000) in use participants was significantly greater versus the reference those who not taken aspirin.

Conclusions: The results of this study suggest that men who took aspirin were more likely to report symptoms of UI and urgent micturition. Therefore, reasonable use of aspirin may support the prevent and prevention of UI.

Background: Falls are an important health concern among older persons. This study attempted to evaluate the characteristics and risk factors of falls in older persons attending a geriatric falls clinic in Qatar, with a particular emphasis on the impact of the COVID-19 epidemic.

Methods: A retrospective analysis was performed on 265 patients aged ≥ 65 years who visited the Falls Clinic between January 1, 2019, and November 28, 2021.

Results: The study population showed a significant prevalence of chronic diseases, with hypertension (94.3%) and diabetes (87.5%) being the most common diseases. A substantial percentage of people reported functional difficulties, such as falls during the recent year and injuries. Interestingly, people recruited during the pandemic used assistive devices at a far higher proportion (46.9% vs. 5.5% previously). This group also reported higher rates of dizziness (54.9% vs. 26.7%, respectively) and pain (50.2% vs. 20.0%, respectively). Participants recruited during the epidemic had significantly elevated systolic blood pressure.

Conclusion: This study showed an increased incidence of comorbidities and functional impairments in older adults who visited a fall prevention clinic in Qatar. These findings suggest that the pandemic may exacerbate population vulnerability.

Background and objectives: Type 2 diabetes mellitus (T2DM) is a common chronic disease in the elderly. Comorbidities, especially neuropathy and retinopathy, significantly increase fall risk in this group. This study aimed to identify fall risk factors in older adults with T2DM.

Materials and methods: From January to June 2024, 242 T2DM patients aged 65 and older were followed at the internal medicine outpatient clinic. Fall risk was assessed using the Performance Oriented Mobility Assessment (POMA), Hendrich II Fall Risk Model (HIIFRM), Barthel Activities of Daily Living Index, and Clinical Frailty Scale (CFS).

Results: Among the patients (median age = 70 years), 41.3% had experienced at least one fall in the previous year. Factors, such as age and diabetes duration were associated with falls. Notably, hypoglycemia (aPR: 1.90, p = 0.017), polypharmacy (aPR: 2.39, p = 0.004), osteoarthritis (aPR: 2.48, p = 0.017), (aPR: 1.70, p = 0.025), and malnutrition (aPR: 1.90, p = 0.007) were independently associated with fall risk.

Conclusions: Fall risk in elderly outpatients with T2DM was linked to various factors, including hospitalization, malnutrition, osteoarthritis, polypharmacy, neuropathy, and hypoglycemia. To mitigate this risk, patient-specific care plans are recommended.

Background: Elevated serum LH levels have been identified in both men and women between the ages of 40 and 70. In previous studies LHCG receptor was detected in the mouse and human penis both in corpus cavernosum penis and corpus spongiosum penis and in the mouse vulva. There is no information about the expression of LHCG receptor in the human vulva up to now. The aim of this study is to examine the expression of the LHCG receptor in the human vulvar tissue to determine whether LH could have an effect on the vulva.

Materials and methods: Vulva tissue was obtained from three patients (ages 68, 76 and 71) undergoing surgery due to squamous cell carcinoma of the vulva. Immunohistochemistry was used for the detection of the LHCG receptor.

Results: Positive immunoreaction for LHCG receptor was detected in the different cell types of the human vulva.

Conclusions: This study provides clear evidence of LHCG receptor expression in various cell types within the human vulva. These findings reinforce the idea that elevated postmenopausal gonadotropin levels may directly impact vulvar tissue. Further studies are indicated.

Objective: Sexual function preservation is a paramount concern for patients undergoing benign prostatic hyperplasia (BPH) surgery, increasingly recognized by physicians. Blue laser vaporization, a novel approach for BPH treatment, has yet to be thoroughly investigated for its effects on sexual function. This prospective study assesses the impact of blue laser vaporization on sexual function in BPH patients, focusing on patient perceptions.

Methods: This study prospectively enrolled BPH patients undergoing blue laser vaporization at our hospital since January 2023. We evaluated the treatment's effectiveness and its impact on preserving sexual function using standardized questionnaires. These included the International Index of Erectile Function (IIEF-5), the Male Sexual Health Questionnaire for Ejaculatory Dysfunction (MSHQ-EjD), and both the International Consultation on Incontinence Modular Questionnaire for Male Lower Urinary Tract Symptoms (ICIQ-MLUTS) and its sexual function component (ICIQ-MLUTSsex).

Results: We included 67 BPH patients with a median age of 65 years in this study, monitoring them for over three months. The results indicate that blue laser vaporization significantly improved International Prostate Symptom Score, Quality of Life, and ICIQ-MLUTS scores in BPH patients (p < 0.001), along with a reduction in post-void residual volume (p < 0.001). Importantly, there were no significant changes in the IIEF-5 score, MSHQ-EjD score, and ICIQ-MLUTSsex score, indicating preservation of sexual function post-surgery.

Conclusion: Blue laser vaporization effectively alleviates lower urinary tract symptoms in BPH patients while preserving erectile and ejaculatory functions.

Background: The relationship between the composition of dietary macronutrient intake and male reproductive health (MRH) has been a topic of interest in public health. This study aimed to evaluate the causal effects of dietary macronutrient composition on MRH.

Methods: Data on the four relative macronutrients intake and seven MRH outcomes were obtained from large genome-wide association studies (GWAS) and FinnGen Biobank. Multiple MR (Mendelian Randomization) methods were utilized in our study, including inverse variance weighted (IVW), MR-Egger, weighted median (WM), and MR-pleiotropy residual sum and outlier (MR-PRESSO).

Results: Our results revealed that a higher relative intake of carbohydrates (RC) was associated with a reduced risk of erectile dysfunction [OR = 0.43; CI = 0.18-1.00; p = 0.0049]. Additionally, a higher relative intake of fat was observed to be a risk factor for abnormal spermatozoa [OR = 19.98; CI = 1.16-345.25; p = 0.039]. The relative intake of sugar (RS) was positively correlated with levels of bioavailable testosterone [OR = 1.23; CI = 1.03-1.47; p = 0.022].

Conclusion: These findings contribute to the evidence of a causal relationship between four relative macronutrients intake and MRH. However, further confirmation of these causal effects through clinical trials is warranted.