Ageing Research Reviews最新文献_第3页

HMGB1, an evolving pleiotropic protein critical for cellular and tissue homeostasis: Role in aging and age-related diseases HMGB1，一种对细胞和组织稳态至关重要的不断演变的多效蛋白：在衰老和老年相关疾病中的作用。

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews

Pub Date : 2024-10-18 DOI: 10.1016/j.arr.2024.102550

Elena Ruggieri , Erika Di Domenico , Andrea Giacomo Locatelli , Flavio Isopo , Sarah Damanti , Rebecca De Lorenzo , Enrico Milan , Giovanna Musco , Patrizia Rovere-Querini , Simone Cenci , Emilie Vénéreau

Aging is a universal biological process characterized by a progressive, cumulative decline in homeostatic capabilities and physiological functions, which inevitably increases vulnerability to diseases. A number of molecular pathomechanisms and hallmarks of aging have been recognized, yet we miss a thorough understanding of their complex interconnectedness. This review explores the molecular and cellular mechanisms underlying human aging, with a focus on the multiple roles of high mobility group Box 1 protein (HMGB1), the archetypal damage-associated molecular pattern (DAMP) molecule. In the nucleus, this non-histone chromatin-associated protein functions as a DNA chaperone and regulator of gene transcription, influencing DNA structure and gene expression. Moreover, this versatile protein can translocate to the cytoplasm to orchestrate other processes, such as autophagy, or be unconventionally secreted into the extracellular environment, where it acts as a DAMP, combining inflammatory and regenerative properties. Notably, lower expression of HMGB1 within the cell and its heightened extracellular release have been associated with diverse age-associated traits, making it a suitable candidate as a universal biomarker of aging. In this review, we outline the evidence implicating HMGB1 in aging, also in light of an evolutionary perspective on its functional pleiotropy, and propose critical issues that need to be addressed to gauge the value of HMGB1 as a potential biomarker across age-related diseases and therapeutic target to promote healthy longevity.

衰老是一个普遍的生物学过程，其特点是体内平衡能力和生理功能的逐步累积衰退，这不可避免地增加了对疾病的脆弱性。人们已经认识到衰老的一些分子病理机制和特征，但我们对它们之间复杂的相互联系还缺乏透彻的了解。这篇综述探讨了人类衰老的分子和细胞机制，重点是高迁移率基团框 1 蛋白（HMGB1）的多重作用，它是典型的损伤相关分子模式（DAMP）分子。在细胞核中，这种非组蛋白染色质相关蛋白发挥着DNA伴侣和基因转录调节器的作用，影响着DNA结构和基因表达。此外，这种多用途蛋白质还能转运到细胞质中，协调自噬等其他过程，或以非传统方式分泌到细胞外环境中，在那里充当 DAMP，兼具炎症和再生特性。值得注意的是，HMGB1 在细胞内的低表达及其在细胞外的高释放与多种与年龄相关的特征有关，这使其成为衰老的通用生物标志物的合适候选者。在这篇综述中，我们概述了 HMGB1 与衰老有关的证据，还从进化的角度探讨了其功能的多义性，并提出了需要解决的关键问题，以衡量 HMGB1 作为跨年龄相关疾病的潜在生物标志物和促进健康长寿的治疗靶点的价值。

{"title":"HMGB1, an evolving pleiotropic protein critical for cellular and tissue homeostasis: Role in aging and age-related diseases","authors":"Elena Ruggieri , Erika Di Domenico , Andrea Giacomo Locatelli , Flavio Isopo , Sarah Damanti , Rebecca De Lorenzo , Enrico Milan , Giovanna Musco , Patrizia Rovere-Querini , Simone Cenci , Emilie Vénéreau","doi":"10.1016/j.arr.2024.102550","DOIUrl":"10.1016/j.arr.2024.102550","url":null,"abstract":"<div><div>Aging is a universal biological process characterized by a progressive, cumulative decline in homeostatic capabilities and physiological functions, which inevitably increases vulnerability to diseases. A number of molecular pathomechanisms and hallmarks of aging have been recognized, yet we miss a thorough understanding of their complex interconnectedness. This review explores the molecular and cellular mechanisms underlying human aging, with a focus on the multiple roles of high mobility group Box 1 protein (HMGB1), the archetypal damage-associated molecular pattern (DAMP) molecule. In the nucleus, this non-histone chromatin-associated protein functions as a DNA chaperone and regulator of gene transcription, influencing DNA structure and gene expression. Moreover, this versatile protein can translocate to the cytoplasm to orchestrate other processes, such as autophagy, or be unconventionally secreted into the extracellular environment, where it acts as a DAMP, combining inflammatory and regenerative properties. Notably, lower expression of HMGB1 within the cell and its heightened extracellular release have been associated with diverse age-associated traits, making it a suitable candidate as a universal biomarker of aging. In this review, we outline the evidence implicating HMGB1 in aging, also in light of an evolutionary perspective on its functional pleiotropy, and propose critical issues that need to be addressed to gauge the value of HMGB1 as a potential biomarker across age-related diseases and therapeutic target to promote healthy longevity.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"102 ","pages":"Article 102550"},"PeriodicalIF":12.5,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of sirtuin 1 in ageing and neurodegenerative disease: A molecular perspective Sirtuin 1 在衰老和神经退行性疾病中的作用：分子视角

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews

Pub Date : 2024-10-17 DOI: 10.1016/j.arr.2024.102545

Riya Thapa , Ehssan Moglad , Muhammad Afzal , Gaurav Gupta , Asif Ahmad Bhat , Waleed Hassan almalki , Imran Kazmi , Sami I. Alzarea , Kumud pant , Thakur Gurjeet Singh , Sachin Kumar Singh , Haider Ali

Sirtuin 1 (SIRT1), an NAD+-dependent deacetylase, has emerged as a key regulator of cellular processes linked to ageing and neurodegeneration. SIRT1 modulates various signalling pathways, including those involved in autophagy, oxidative stress, and mitochondrial function, which are critical in the pathogenesis of neurodegenerative diseases. This review explores the therapeutic potential of SIRT1 in several neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and Amyotrophic Lateral Sclerosis (ALS). Preclinical studies have demonstrated that SIRT1 activators, such as resveratrol, SRT1720, and SRT2104, can alleviate disease symptoms by reducing oxidative stress, enhancing autophagic flux, and promoting neuronal survival. Ongoing clinical trials are evaluating the efficacy of these SIRT1 activators, providing hope for future therapeutic strategies targeting SIRT1 in neurodegenerative diseases. This review explores the role of SIRT1 in ageing and neurodegenerative diseases, with a particular focus on its molecular mechanisms, therapeutic potential, and clinical applications.

Sirtuin 1（SIRT1）是一种依赖于 NAD+ 的去乙酰化酶，已成为与衰老和神经退行性疾病相关的细胞过程的关键调节因子。SIRT1 可调节各种信号通路，包括参与自噬、氧化应激和线粒体功能的信号通路，这些信号通路在神经退行性疾病的发病机制中至关重要。本综述探讨了 SIRT1 在几种神经退行性疾病中的治疗潜力，包括阿尔茨海默病（AD）、帕金森病（PD）、亨廷顿病（HD）和肌萎缩侧索硬化症（ALS）。临床前研究表明，白藜芦醇、SRT1720 和 SRT2104 等 SIRT1 激活剂可通过降低氧化应激、增强自噬通量和促进神经元存活来缓解疾病症状。目前正在进行的临床试验正在评估这些 SIRT1 激活剂的疗效，这为未来针对神经退行性疾病的 SIRT1 治疗策略带来了希望。这篇综述探讨了 SIRT1 在衰老和神经退行性疾病中的作用，尤其关注其分子机制、治疗潜力和临床应用。

{"title":"The role of sirtuin 1 in ageing and neurodegenerative disease: A molecular perspective","authors":"Riya Thapa , Ehssan Moglad , Muhammad Afzal , Gaurav Gupta , Asif Ahmad Bhat , Waleed Hassan almalki , Imran Kazmi , Sami I. Alzarea , Kumud pant , Thakur Gurjeet Singh , Sachin Kumar Singh , Haider Ali","doi":"10.1016/j.arr.2024.102545","DOIUrl":"10.1016/j.arr.2024.102545","url":null,"abstract":"<div><div>Sirtuin 1 (SIRT1), an NAD+-dependent deacetylase, has emerged as a key regulator of cellular processes linked to ageing and neurodegeneration. SIRT1 modulates various signalling pathways, including those involved in autophagy, oxidative stress, and mitochondrial function, which are critical in the pathogenesis of neurodegenerative diseases. This review explores the therapeutic potential of SIRT1 in several neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and Amyotrophic Lateral Sclerosis (ALS). Preclinical studies have demonstrated that SIRT1 activators, such as resveratrol, SRT1720, and SRT2104, can alleviate disease symptoms by reducing oxidative stress, enhancing autophagic flux, and promoting neuronal survival. Ongoing clinical trials are evaluating the efficacy of these SIRT1 activators, providing hope for future therapeutic strategies targeting SIRT1 in neurodegenerative diseases. This review explores the role of SIRT1 in ageing and neurodegenerative diseases, with a particular focus on its molecular mechanisms, therapeutic potential, and clinical applications.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"102 ","pages":"Article 102545"},"PeriodicalIF":12.5,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breaking new ground on human health and well-being with epigenetic clocks: A systematic review and meta-analysis of epigenetic age acceleration associations 利用表观遗传时钟为人类健康和福祉开辟新天地：表观遗传年龄加速相关性的系统回顾和荟萃分析。

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews

Pub Date : 2024-10-17 DOI: 10.1016/j.arr.2024.102552

Olga Chervova , Kseniia Panteleeva , Elizabeth Chernysheva , Tyas Arum Widayati , Žan Florjanic Baronik , Natálie Hrbková , Jadesada Louis Schneider , Martin Bobak , Stephan Beck , Vitaly Voloshin

Epigenetic clocks provide an accurate molecular readout of epigenetic age and epigenetic age acceleration (EAA) derived from DNA methylation data have shown promise as biomarkers of ageing. This systematic review synthesised research on associations between EAA measures and various physiological, cognitive, social, and environmental factors. A comprehensive search strategy identified 299 publications reporting 1050 unique EAA-factor associations based on 53 methylation clocks. Random-effects meta-analyses pooled results across studies for selected EAA-factor pairs. Significant pooled associations emerged, providing insights into relationships between specific factors and accelerated epigenetic ageing. We developed a novel four-level classification system to categorise this diverse range of factors and enable a structured synthesis. To aid further research planning in this rapidly evolving field, TEAPEE (Tracker of EAA Associations with Phenotype & Environmental Exposure) - an interactive, searchable web table detailing all EAA-factor associations - was developed, cataloguing the epigenetic clocks, associated factors, classification categories, and direct links to the original studies. This resource will empower future investigations into the multifaceted determinants of epigenetic ageing, contributing to a deeper understanding of the epigenome’s sensitivity to various life experiences and exposures.

表观遗传时钟提供了表观遗传年龄的精确分子读数，而从 DNA 甲基化数据中得出的表观遗传年龄加速度（EAA）有望成为老化的生物标志物。本系统综述综合了有关 EAA 测量与各种生理、认知、社会和环境因素之间关系的研究。通过综合搜索策略发现了 299 篇出版物，这些出版物基于 53 个甲基化时钟报告了 1,050 个独特的 EAA 因素关联。随机效应荟萃分析对选定的 EAA 因素对的研究结果进行了汇总。研究发现了一些重要的集合关联，为了解特定因素与表观遗传加速衰老之间的关系提供了线索。我们开发了一种新颖的四级分类系统来对这些不同的因素进行分类，并进行结构化综合。为了帮助这一快速发展领域的进一步研究规划，我们开发了 TEAPEE（表型与环境暴露的表观遗传加速老化关联追踪器）--一个详细列出所有表观遗传加速老化关联因素的可搜索互动式网络表格，对表观遗传时钟、关联因素、分类类别和原始研究的直接链接进行了编目。这一资源将有助于今后对表观遗传老化的多方面决定因素进行研究，有助于加深对表观基因组对各种生活经历和暴露的敏感性的理解。

{"title":"Breaking new ground on human health and well-being with epigenetic clocks: A systematic review and meta-analysis of epigenetic age acceleration associations","authors":"Olga Chervova , Kseniia Panteleeva , Elizabeth Chernysheva , Tyas Arum Widayati , Žan Florjanic Baronik , Natálie Hrbková , Jadesada Louis Schneider , Martin Bobak , Stephan Beck , Vitaly Voloshin","doi":"10.1016/j.arr.2024.102552","DOIUrl":"10.1016/j.arr.2024.102552","url":null,"abstract":"<div><div>Epigenetic clocks provide an accurate molecular readout of epigenetic age and epigenetic age acceleration (EAA) derived from DNA methylation data have shown promise as biomarkers of ageing. This systematic review synthesised research on associations between EAA measures and various physiological, cognitive, social, and environmental factors. A comprehensive search strategy identified 299 publications reporting 1050 unique EAA-factor associations based on 53 methylation clocks. Random-effects meta-analyses pooled results across studies for selected EAA-factor pairs. Significant pooled associations emerged, providing insights into relationships between specific factors and accelerated epigenetic ageing. We developed a novel four-level classification system to categorise this diverse range of factors and enable a structured synthesis. To aid further research planning in this rapidly evolving field, TEAPEE (<strong>T</strong>racker of <strong>E</strong>AA <strong>A</strong>ssociations with <strong>P</strong>henotype & <strong>E</strong>nvironmental <strong>E</strong>xposure) - an interactive, searchable web table detailing all EAA-factor associations - was developed, cataloguing the epigenetic clocks, associated factors, classification categories, and direct links to the original studies. This resource will empower future investigations into the multifaceted determinants of epigenetic ageing, contributing to a deeper understanding of the epigenome’s sensitivity to various life experiences and exposures.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"102 ","pages":"Article 102552"},"PeriodicalIF":12.5,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting inflammation and gut microbiota with antibacterial therapy: Implications for central nervous system health 以抗菌疗法针对炎症和肠道微生物群：对中枢神经系统健康的影响

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews

Pub Date : 2024-10-16 DOI: 10.1016/j.arr.2024.102544

Jing Wei , Chunmeng Liu , Dalian Qin , Fang Ren , Junguo Duan , Ting Chen , Anguo Wu

The complex symbiotic relationship between inflammation, the gut microbiota, and the central nervous system (CNS) has become a pivotal focus of contemporary biomedical research. Inflammation, as a physiological defense mechanism, plays a dual role as both a protective and pathological factor, and is intricately associated with gut microbiota homeostasis, often termed the "second brain." The gutbrain axis (GBA) exemplifies this multifaceted interaction, where gut health exerts significantly regulatory effects on CNS functions. Antibacterial therapies represent both promising and challenging strategies for modulating inflammation and gut microbiota composition to confer CNS benefits. However, while such therapies may exert positive modulatory effects on the gut microbiota, they also carry the potential to disrupt microbial equilibrium, potentially exacerbating neurological dysfunction. Recent advances have provided critical insights into the therapeutic implications of antibacterial interventions; nevertheless, the application of these therapies in the context of CNS health warrants a judicious and evidence-based approach. As research progresses, deeper investigation into the microbial–neural interface is essential to fully realize the potential of therapies targeting inflammation and the gut microbiota for CNS health. Future efforts should focus on refining antibacterial interventions to modulate the gut microbiota while minimizing disruption to microbial balance, thereby reducing risks and enhancing efficacy in CNS-related conditions. In conclusion, despite challenges, a more comprehensive understanding of the GBA, along with precise modulation through targeted antibacterial therapies, offers significant promise for advancing CNS disorder treatment. Continued research in this area will lead to innovative interventions and improved patient outcomes.

炎症、肠道微生物群和中枢神经系统（CNS）之间复杂的共生关系已成为当代生物医学研究的一个关键焦点。炎症作为一种生理防御机制，扮演着保护因素和病理因素的双重角色，并与肠道微生物群平衡错综复杂地联系在一起，通常被称为 "第二大脑"。肠脑轴（GBA）体现了这种多方面的相互作用，其中肠道健康对中枢神经系统功能具有显著的调节作用。抗菌疗法既是调节炎症和肠道微生物群组成以获得中枢神经系统益处的大有可为的策略，也是具有挑战性的策略。然而，虽然此类疗法可能会对肠道微生物群产生积极的调节作用，但也有可能破坏微生物平衡，从而加剧神经功能紊乱。最近的研究进展为了解抗菌干预措施的治疗意义提供了重要依据；然而，在中枢神经系统健康的背景下应用这些疗法需要采取审慎和循证的方法。随着研究的深入，必须对微生物-神经界面进行更深入的调查，以充分发挥针对炎症和肠道微生物群的疗法在促进中枢神经系统健康方面的潜力。未来的工作重点应该是完善抗菌干预措施，以调节肠道微生物群，同时最大限度地减少对微生物平衡的破坏，从而降低中枢神经系统相关疾病的风险并提高疗效。总之，尽管存在挑战，但更全面地了解肠道微生物区系以及通过靶向抗菌疗法进行精确调节，为中枢神经系统疾病的治疗带来了巨大希望。在这一领域的持续研究将带来创新性的干预措施，并改善患者的治疗效果。

{"title":"Targeting inflammation and gut microbiota with antibacterial therapy: Implications for central nervous system health","authors":"Jing Wei , Chunmeng Liu , Dalian Qin , Fang Ren , Junguo Duan , Ting Chen , Anguo Wu","doi":"10.1016/j.arr.2024.102544","DOIUrl":"10.1016/j.arr.2024.102544","url":null,"abstract":"<div><div>The complex symbiotic relationship between inflammation, the gut microbiota, and the central nervous system (CNS) has become a pivotal focus of contemporary biomedical research. Inflammation, as a physiological defense mechanism, plays a dual role as both a protective and pathological factor, and is intricately associated with gut microbiota homeostasis, often termed the \"second brain.\" The gut<img>brain axis (GBA) exemplifies this multifaceted interaction, where gut health exerts significantly regulatory effects on CNS functions. Antibacterial therapies represent both promising and challenging strategies for modulating inflammation and gut microbiota composition to confer CNS benefits. However, while such therapies may exert positive modulatory effects on the gut microbiota, they also carry the potential to disrupt microbial equilibrium, potentially exacerbating neurological dysfunction. Recent advances have provided critical insights into the therapeutic implications of antibacterial interventions; nevertheless, the application of these therapies in the context of CNS health warrants a judicious and evidence-based approach. As research progresses, deeper investigation into the microbial–neural interface is essential to fully realize the potential of therapies targeting inflammation and the gut microbiota for CNS health. Future efforts should focus on refining antibacterial interventions to modulate the gut microbiota while minimizing disruption to microbial balance, thereby reducing risks and enhancing efficacy in CNS-related conditions. In conclusion, despite challenges, a more comprehensive understanding of the GBA, along with precise modulation through targeted antibacterial therapies, offers significant promise for advancing CNS disorder treatment. Continued research in this area will lead to innovative interventions and improved patient outcomes.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"102 ","pages":"Article 102544"},"PeriodicalIF":12.5,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing Brainwave Entrainment: A Non-invasive Strategy To Alleviate Neurological Disorder Symptoms 利用脑波诱导：缓解神经紊乱症状的非侵入性策略。

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews

Pub Date : 2024-10-16 DOI: 10.1016/j.arr.2024.102547

Mehar Sahu , Rashmi K. Ambasta , Suman R. Das , Manoj K. Mishra , Anil Shanker , Pravir Kumar

From 1990–2019, the burden of neurological disorders varied considerably across countries and regions. Psychiatric disorders, often emerging in early to mid-adulthood, are linked to late-life neurodegenerative diseases like Alzheimer’s disease and Parkinson’s disease. Individuals with conditions such as Major Depressive Disorder, Anxiety Disorder, Schizophrenia, and Bipolar Disorder face up to four times higher risk of developing neurodegenerative disorders. Contrarily, 65 % of those with neurodegenerative conditions experience severe psychiatric symptoms during their illness. Further, the limitation of medical resources continues to make this burden a significant global and local challenge. Therefore, brainwave entrainment provides therapeutic avenues for improving the symptoms of diseases. Brainwaves are rhythmic oscillations produced either spontaneously or in response to stimuli. Key brainwave patterns include gamma, beta, alpha, theta, and delta waves, yet the underlying physiological mechanisms and the brain's ability to shift between these dynamic states remain areas for further exploration. In neurological disorders, brainwaves are often disrupted, a phenomenon termed "oscillopathy". However, distinguishing these impaired oscillations from the natural variability in brainwave activity across different regions and functional states poses significant challenges. Brainwave-mediated therapeutics represents a promising research field aimed at correcting dysfunctional oscillations. Herein, we discuss a range of non-invasive techniques such as non-invasive brain stimulation (NIBS), neurologic music therapy (NMT), gamma stimulation, and somatosensory interventions using light, sound, and visual stimuli. These approaches, with their minimal side effects and cost-effectiveness, offer potential therapeutic benefits. When integrated, they may not only help in delaying disease progression but also contribute to the development of innovative medical devices for neurological care.

从 1990 年到 2019 年，不同国家和地区的神经系统疾病负担差异很大。精神障碍通常在成年早中期出现，与阿尔茨海默病和帕金森病等晚年神经退行性疾病有关。患有重度抑郁症、焦虑症、精神分裂症和双相情感障碍等疾病的人罹患神经退行性疾病的风险要高出四倍。相反，65% 的神经退行性疾病患者在患病期间会出现严重的精神症状。此外，由于医疗资源的限制，这一负担仍然是全球和地方面临的重大挑战。因此，脑波诱导为改善疾病症状提供了治疗途径。脑电波是自发产生或在刺激下产生的有节奏的振荡。主要的脑电波模式包括伽马波、贝塔波、阿尔法波、θ波和δ波，但其潜在的生理机制和大脑在这些动态状态之间转换的能力仍有待进一步探索。在神经系统疾病中，脑电波通常会受到干扰，这种现象被称为 "振荡病"。然而，如何将这些受损的振荡与不同区域和功能状态下脑电波活动的自然变异性区分开来，是一项重大挑战。以脑电波为媒介的疗法是一个前景广阔的研究领域，旨在纠正功能失调的振荡。在此，我们将讨论一系列非侵入性技术，如非侵入性脑部刺激（NIBS）、神经音乐疗法（NMT）、伽马刺激以及使用光、声和视觉刺激的体感干预。这些方法副作用小、成本效益高，具有潜在的治疗效果。如果将这些方法结合起来，不仅有助于延缓疾病的发展，还有助于开发用于神经护理的创新医疗设备。

{"title":"Harnessing Brainwave Entrainment: A Non-invasive Strategy To Alleviate Neurological Disorder Symptoms","authors":"Mehar Sahu , Rashmi K. Ambasta , Suman R. Das , Manoj K. Mishra , Anil Shanker , Pravir Kumar","doi":"10.1016/j.arr.2024.102547","DOIUrl":"10.1016/j.arr.2024.102547","url":null,"abstract":"<div><div>From 1990–2019, the burden of neurological disorders varied considerably across countries and regions. Psychiatric disorders, often emerging in early to mid-adulthood, are linked to late-life neurodegenerative diseases like Alzheimer’s disease and Parkinson’s disease. Individuals with conditions such as Major Depressive Disorder, Anxiety Disorder, Schizophrenia, and Bipolar Disorder face up to four times higher risk of developing neurodegenerative disorders. Contrarily, 65 % of those with neurodegenerative conditions experience severe psychiatric symptoms during their illness. Further, the limitation of medical resources continues to make this burden a significant global and local challenge. Therefore, brainwave entrainment provides therapeutic avenues for improving the symptoms of diseases. Brainwaves are rhythmic oscillations produced either spontaneously or in response to stimuli. Key brainwave patterns include gamma, beta, alpha, theta, and delta waves, yet the underlying physiological mechanisms and the brain's ability to shift between these dynamic states remain areas for further exploration. In neurological disorders, brainwaves are often disrupted, a phenomenon termed \"oscillopathy\". However, distinguishing these impaired oscillations from the natural variability in brainwave activity across different regions and functional states poses significant challenges. Brainwave-mediated therapeutics represents a promising research field aimed at correcting dysfunctional oscillations. Herein, we discuss a range of non-invasive techniques such as non-invasive brain stimulation (NIBS), neurologic music therapy (NMT), gamma stimulation, and somatosensory interventions using light, sound, and visual stimuli. These approaches, with their minimal side effects and cost-effectiveness, offer potential therapeutic benefits. When integrated, they may not only help in delaying disease progression but also contribute to the development of innovative medical devices for neurological care.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"101 ","pages":"Article 102547"},"PeriodicalIF":12.5,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic clocks and programmatic aging 表观遗传时钟和程序性衰老

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews

Pub Date : 2024-10-15 DOI: 10.1016/j.arr.2024.102546

David Gems , Roop Singh Virk , João Pedro de Magalhães

The last decade has seen remarkable progress in the characterization of methylation clocks that can serve as indicators of biological age in humans and many other mammalian species. While the biological processes of aging that underlie these clocks have remained unclear, several clues have pointed to a link to developmental mechanisms. These include the presence in the vicinity of clock CpG sites of genes that specify development, including those of the Hox (homeobox) and polycomb classes. Here we discuss how recent advances in programmatic theories of aging provide a framework within which methylation clocks can be understood as part of a developmental process of aging. This includes how such clocks evolve, how developmental mechanisms cause aging, and how they give rise to late-life disease. The combination of ideas from evolutionary biology, biogerontology and developmental biology open a path to a new discipline, that of developmental gerontology (devo-gero). Drawing on the properties of methylation clocks, we offer several new hypotheses that exemplify devo-gero thinking. We suggest that polycomb controls a trade-off between earlier developmental fidelity and later developmental plasticity. We also propose the existence of an evolutionarily-conserved developmental sequence spanning ontogenesis, adult development and aging, that both constrains and determines the evolution of aging.

在过去的十年中，甲基化钟的研究取得了显著进展，甲基化钟可以作为人类和许多其他哺乳动物生物年龄的指标。虽然这些时钟所依据的衰老生物学过程仍不清楚，但有几条线索表明它们与发育机制有关。这些线索包括时钟 CpG 位点附近存在指定发育的基因，包括 Hox（homeobox）和 polycomb 类基因。在这里，我们将讨论衰老程序理论的最新进展如何提供了一个框架，在这个框架内，甲基化时钟可以被理解为衰老发育过程的一部分。这包括这种时钟如何进化、发育机制如何导致衰老以及它们如何引发晚年疾病。进化生物学、生物老年学和发育生物学的观点相结合，为发育老年学（devo-gero）这一新学科开辟了道路。借鉴甲基化钟的特性，我们提出了几项新的假设，体现了发展老年学的思想。我们认为，多聚酶控制着早期发育保真度与后期发育可塑性之间的权衡。我们还提出存在一个进化保守的发育序列，它跨越了本体发育、成人发育和衰老，既制约又决定了衰老的进化。

{"title":"Epigenetic clocks and programmatic aging","authors":"David Gems , Roop Singh Virk , João Pedro de Magalhães","doi":"10.1016/j.arr.2024.102546","DOIUrl":"10.1016/j.arr.2024.102546","url":null,"abstract":"<div><div>The last decade has seen remarkable progress in the characterization of methylation clocks that can serve as indicators of biological age in humans and many other mammalian species. While the biological processes of aging that underlie these clocks have remained unclear, several clues have pointed to a link to developmental mechanisms. These include the presence in the vicinity of clock CpG sites of genes that specify development, including those of the Hox (homeobox) and polycomb classes. Here we discuss how recent advances in programmatic theories of aging provide a framework within which methylation clocks can be understood as part of a developmental process of aging. This includes how such clocks evolve, how developmental mechanisms cause aging, and how they give rise to late-life disease. The combination of ideas from evolutionary biology, biogerontology and developmental biology open a path to a new discipline, that of <em>developmental gerontology</em> (<em>devo-gero</em>). Drawing on the properties of methylation clocks, we offer several new hypotheses that exemplify devo-gero thinking. We suggest that polycomb controls a trade-off between earlier developmental fidelity and later developmental plasticity. We also propose the existence of an evolutionarily-conserved <em>developmental sequence</em> spanning ontogenesis, adult development and aging, that both constrains and determines the evolution of aging.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"101 ","pages":"Article 102546"},"PeriodicalIF":12.5,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The aging heart in focus: The advanced understanding of heart failure with preserved ejection fraction 聚焦衰老的心脏：对射血分数保留型心力衰竭的深入了解

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews

Pub Date : 2024-10-12 DOI: 10.1016/j.arr.2024.102542

Zhewei Zhang , Yu Wang , Xiangqi Chen , Chuan Wu , Jingyue Zhou , Yan Chen , Xiaojing Liu , Xiaoqiang Tang

Heart failure with preserved ejection fraction (HFpEF) accounts for 50 % of heart failure (HF) cases, making it the most common type of HF, and its prevalence continues to increase in the aging society. HFpEF is a systemic syndrome resulting from many risk factors, such as aging, metabolic syndrome, and hypertension, and its clinical features are highly heterogeneous in different populations. HFpEF syndrome involves the dysfunction of multiple organs, including the heart, lung, muscle, and vascular system. The heart shows dysfunction of various cells, including cardiomyocytes, endothelial cells, fibroblasts, adipocytes, and immune cells. The complex etiology and pathobiology limit experimental research on HFpEF in animal models, delaying a comprehensive understanding of the mechanisms and making treatment difficult. Recently, many scientists and cardiologists have attempted to improve the clinical outcomes of HFpEF. Recent advances in clinically related animal models and systemic pathology studies have improved our understanding of HFpEF, and clinical trials involving sodium-glucose cotransporter 2 inhibitors have significantly enhanced our confidence in treating HFpEF. This review provides an updated comprehensive discussion of the etiology and pathobiology, molecular and cellular mechanisms, preclinical animal models, and therapeutic trials in animals and patients to enhance our understanding of HFpEF and improve clinical outcomes.

射血分数保留型心力衰竭（HFpEF）占心力衰竭（HF）病例的 50%，是最常见的心力衰竭类型，随着老龄化社会的到来，其发病率持续上升。HFpEF 是一种由多种风险因素（如衰老、代谢综合征和高血压）导致的全身性综合征，其临床特征在不同人群中具有高度异质性。HFpEF 综合征涉及多个器官的功能障碍，包括心脏、肺、肌肉和血管系统。心脏中的心肌细胞、内皮细胞、成纤维细胞、脂肪细胞和免疫细胞等多种细胞均出现功能障碍。复杂的病因和病理生物学限制了对高频心衰动物模型的实验研究，延迟了对其机制的全面了解，给治疗带来困难。最近，许多科学家和心脏病专家都在尝试改善 HFpEF 的临床疗效。与临床相关的动物模型和系统病理学研究的最新进展提高了我们对 HFpEF 的认识，而钠-葡萄糖共转运体 2 抑制剂的临床试验则大大增强了我们治疗 HFpEF 的信心。本综述对病因和病理生物学、分子和细胞机制、临床前动物模型以及动物和患者治疗试验进行了最新的全面讨论，以加深我们对 HFpEF 的理解并改善临床疗效。

{"title":"The aging heart in focus: The advanced understanding of heart failure with preserved ejection fraction","authors":"Zhewei Zhang , Yu Wang , Xiangqi Chen , Chuan Wu , Jingyue Zhou , Yan Chen , Xiaojing Liu , Xiaoqiang Tang","doi":"10.1016/j.arr.2024.102542","DOIUrl":"10.1016/j.arr.2024.102542","url":null,"abstract":"<div><div>Heart failure with preserved ejection fraction (HFpEF) accounts for 50 % of heart failure (HF) cases, making it the most common type of HF, and its prevalence continues to increase in the aging society. HFpEF is a systemic syndrome resulting from many risk factors, such as aging, metabolic syndrome, and hypertension, and its clinical features are highly heterogeneous in different populations. HFpEF syndrome involves the dysfunction of multiple organs, including the heart, lung, muscle, and vascular system. The heart shows dysfunction of various cells, including cardiomyocytes, endothelial cells, fibroblasts, adipocytes, and immune cells. The complex etiology and pathobiology limit experimental research on HFpEF in animal models, delaying a comprehensive understanding of the mechanisms and making treatment difficult. Recently, many scientists and cardiologists have attempted to improve the clinical outcomes of HFpEF. Recent advances in clinically related animal models and systemic pathology studies have improved our understanding of HFpEF, and clinical trials involving sodium-glucose cotransporter 2 inhibitors have significantly enhanced our confidence in treating HFpEF. This review provides an updated comprehensive discussion of the etiology and pathobiology, molecular and cellular mechanisms, preclinical animal models, and therapeutic trials in animals and patients to enhance our understanding of HFpEF and improve clinical outcomes.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"101 ","pages":"Article 102542"},"PeriodicalIF":12.5,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142446507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of ketogenic diets on insulin-like growth factor (IGF)-1 in humans: A systematic review and meta-analysis 生酮饮食对人体胰岛素样生长因子（IGF）-1 的影响：系统回顾和荟萃分析。

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews

Pub Date : 2024-10-11 DOI: 10.1016/j.arr.2024.102531

Gayathiri Rajakumar , Maria Lastra Cagigas , Tian Wang , Angela Y. Pan , Tiana Pelaia , Stephen J. Fuller , Luigi Fontana

Background

Insulin-like growth factor (IGF)-1 plays a role in aging and cancer biology, with fasting known to reduce serum IGF-1 levels in human adults. However, the impact of ad libitum ketogenic diets (KDs) on IGF-1 levels remains unclear.

Methods

Adhering to PRISMA guidelines, we conducted a meta-analysis of human trials by systematically searching Ovid, PubMed, Scopus, and CENTRAL Libraries until June 2023. Eligible studies prescribed KDs to adults of any health status, confirmed ketosis, and measured serum IGF-1. Protocols involving prescribed fasting or energy restriction were excluded. Mean differences (MD) and 95 % confidence intervals (CIs) were calculated longitudinally between pre- and post-intervention measurements for the KD groups.

Results

Among twelve publications meeting the inclusion criteria, 522 individuals participated, with 236 completing KDs. The intervention duration ranged from 1 to 20 weeks. Pooled results from ten trials showed a significant reduction in serum IGF-1 levels post-intervention (MD: −24.9 ng/mL [95 % CI −31.7 to −18.1]; p<0.0001) with low heterogeneity across studies (I²=27 %, p=0.19). KDs were also associated with significantly decreased fasting insulin (MD: −2.57 mU/L [95 % CI −4.41 to −0.74], p=0.006) and glucose (MD: −7.30 mg/dL [95 % CI −11.62 to −2.98], p=0.0009), although heterogeneity was significant. Subgroup analyses on study design, gender, dietary duration, and oncological status revealed no significant differences.

Conclusion

Ad libitum KDs (>55 % fat) effectively induce ketosis and can lower serum IGF-1 by 20 %, fasting glucose by 6 % and insulin by 29 %. This clinically notable reduction in IGF-1 can be attained without the need for a prescribed fasting or severe calorie restriction regimen. Further investigation is warranted to explore the impact of KDs on ageing biomarkers and cancer management.

背景：胰岛素样生长因子（IGF）-1在衰老和癌症生物学中发挥作用，已知禁食会降低成人血清中的IGF-1水平。然而，自由生酮饮食（KD）对 IGF-1 水平的影响仍不清楚：根据 PRISMA 指南，我们通过系统检索 Ovid、PubMed、Scopus 和 CENTRAL 图书馆，对截至 2023 年 6 月的人体试验进行了荟萃分析。符合条件的研究为任何健康状况的成人开具了酮病处方，确认了酮病，并测量了血清 IGF-1。涉及规定禁食或能量限制的方案被排除在外。纵向计算KD组干预前后测量值的平均差（MD）和95%置信区间（CI）：在12篇符合纳入标准的出版物中，共有522人参与，其中236人被分配到KD组。干预持续时间为 1-20 周不等。十项试验的汇总结果显示，干预后血清 IGF-1 水平显著降低（MD：-24.9ng/mL [95% CI -31.7 to -18.1]；P2=27%，P=0.19）。KDs还与空腹胰岛素（MD：-2.57 mU/L [95% CI -4.41 to -0.74]，p=0.006）和血糖（MD：-7.30mg/dL [95% CI -11.62 to -2.98]，p=0.0009）的显著下降有关，尽管异质性很明显。对研究设计、性别、膳食持续时间和肿瘤状况进行的亚组分析显示没有明显差异：结论：开食性酮症酸中毒（脂肪含量大于 55%）可有效诱导酮症，使血清 IGF-1 降低 20%，空腹血糖降低 6%，胰岛素降低 29%。临床上，IGF-1的显著降低无需规定禁食或严格限制卡路里摄入量即可实现。我们有必要进一步研究 KDs 对衰老生物标志物和癌症管理的影响。

{"title":"Effect of ketogenic diets on insulin-like growth factor (IGF)-1 in humans: A systematic review and meta-analysis","authors":"Gayathiri Rajakumar , Maria Lastra Cagigas , Tian Wang , Angela Y. Pan , Tiana Pelaia , Stephen J. Fuller , Luigi Fontana","doi":"10.1016/j.arr.2024.102531","DOIUrl":"10.1016/j.arr.2024.102531","url":null,"abstract":"<div><h3>Background</h3><div>Insulin-like growth factor (IGF)-1 plays a role in aging and cancer biology, with fasting known to reduce serum IGF-1 levels in human adults. However, the impact of <em>ad libitum</em> ketogenic diets (KDs) on IGF-1 levels remains unclear.</div></div><div><h3>Methods</h3><div>Adhering to PRISMA guidelines, we conducted a meta-analysis of human trials by systematically searching Ovid, PubMed, Scopus, and CENTRAL Libraries until June 2023. Eligible studies prescribed KDs to adults of any health status, confirmed ketosis, and measured serum IGF-1. Protocols involving prescribed fasting or energy restriction were excluded. Mean differences (MD) and 95 % confidence intervals (CIs) were calculated longitudinally between pre- and post-intervention measurements for the KD groups.</div></div><div><h3>Results</h3><div>Among twelve publications meeting the inclusion criteria, 522 individuals participated, with 236 completing KDs. The intervention duration ranged from 1 to 20 weeks. Pooled results from ten trials showed a significant reduction in serum IGF-1 levels post-intervention (MD: −24.9 ng/mL [95 % CI −31.7 to −18.1]; p<0.0001) with low heterogeneity across studies (I<sup>2</sup>=27 %, p=0.19). KDs were also associated with significantly decreased fasting insulin (MD: −2.57 mU/L [95 % CI −4.41 to −0.74], p=0.006) and glucose (MD: −7.30 mg/dL [95 % CI −11.62 to −2.98], p=0.0009), although heterogeneity was significant. Subgroup analyses on study design, gender, dietary duration, and oncological status revealed no significant differences.</div></div><div><h3>Conclusion</h3><div><em>Ad libitum</em> KDs (>55 % fat) effectively induce ketosis and can lower serum IGF-1 by 20 %, fasting glucose by 6 % and insulin by 29 %. This clinically notable reduction in IGF-1 can be attained without the need for a prescribed fasting or severe calorie restriction regimen. Further investigation is warranted to explore the impact of KDs on ageing biomarkers and cancer management.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"102 ","pages":"Article 102531"},"PeriodicalIF":12.5,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retrotransposon SINEs in age-related diseases: Mechanisms and therapeutic implications 逆转录转座子 SINEs 在老年相关疾病中的作用：机制和治疗意义。

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews

Pub Date : 2024-10-10 DOI: 10.1016/j.arr.2024.102539

Suleman Shah , Siyi Yu , Chen Zhang , Ilyas Ali , Xiufang Wang , Youhui Qian , Tian Xiao

Retrotransposons are self-replicating genomic elements that move from one genomic location to another using a “copy-and-paste” method involving RNA intermediaries. One family of retrotransposon that has garnered considerable attention for its association with age-related diseases and anti-aging interventions is the short interspersed nuclear elements (SINEs). This review summarizes current knowledge on the roles of SINEs in aging processes and therapies. To underscore the significant research on the involvement of SINEs in aging-related diseases, we commence by outlining compelling evidence on the classification and mechanism, highlighting implications in age-related phenomena. The intricate relationship between SINEs and diseases such as neurodegenerative disorders, heart failure, high blood pressure, atherosclerosis, type 2 diabetes mellitus, osteoporosis, visual system dysfunctions, and cancer is explored, emphasizing their roles in various age-related diseases. Recent investigations into the anti-aging potential of SINE-targeted treatments are examined, with particular attention to how SINE antisense RNA mitigate age-related alterations at the cellular and molecular levels, offering insights into potential therapeutic targets for age-related pathologies. This review aims to compile the most recent advances on the multifaceted roles of SINE retrotransposons in age-related diseases and anti-aging interventions, providing valuable insights into underlying mechanisms and therapeutic avenues for promoting healthy aging.

逆转录转座子是一种自我复制的基因组元件，它通过涉及 RNA 中间体的 "复制粘贴 "方法从一个基因组位置移动到另一个基因组位置。短穿插核元素（SINEs）是逆转录转座子的一个家族，因其与老年相关疾病和抗衰老干预措施有关而备受关注。本综述总结了目前有关 SINEs 在衰老过程和疗法中的作用的知识。为了强调有关 SINEs 参与衰老相关疾病的重要研究，我们首先概述了有关其分类和机制的有力证据，并强调了其对衰老相关现象的影响。我们探讨了 SINEs 与神经退行性疾病、心力衰竭、高血压、动脉粥样硬化、2 型糖尿病、骨质疏松症、视觉系统功能障碍和癌症等疾病之间错综复杂的关系，强调了它们在各种老年相关疾病中的作用。本综述还探讨了有关 SINE 靶向治疗抗衰老潜力的最新研究，尤其关注 SINE 反义 RNA 如何在细胞和分子水平上缓解与年龄相关的改变，从而为老年相关病症的潜在治疗靶点提供见解。这篇综述旨在汇集有关 SINE 逆转录座子在老年相关疾病和抗衰老干预中的多方面作用的最新进展，为促进健康老龄化的潜在机制和治疗途径提供有价值的见解。

{"title":"Retrotransposon SINEs in age-related diseases: Mechanisms and therapeutic implications","authors":"Suleman Shah , Siyi Yu , Chen Zhang , Ilyas Ali , Xiufang Wang , Youhui Qian , Tian Xiao","doi":"10.1016/j.arr.2024.102539","DOIUrl":"10.1016/j.arr.2024.102539","url":null,"abstract":"<div><div>Retrotransposons are self-replicating genomic elements that move from one genomic location to another using a “copy-and-paste” method involving RNA intermediaries. One family of retrotransposon that has garnered considerable attention for its association with age-related diseases and anti-aging interventions is the short interspersed nuclear elements (SINEs). This review summarizes current knowledge on the roles of SINEs in aging processes and therapies. To underscore the significant research on the involvement of SINEs in aging-related diseases, we commence by outlining compelling evidence on the classification and mechanism, highlighting implications in age-related phenomena. The intricate relationship between SINEs and diseases such as neurodegenerative disorders, heart failure, high blood pressure, atherosclerosis, type 2 diabetes mellitus, osteoporosis, visual system dysfunctions, and cancer is explored, emphasizing their roles in various age-related diseases. Recent investigations into the anti-aging potential of SINE-targeted treatments are examined, with particular attention to how SINE antisense RNA mitigate age-related alterations at the cellular and molecular levels, offering insights into potential therapeutic targets for age-related pathologies. This review aims to compile the most recent advances on the multifaceted roles of SINE retrotransposons in age-related diseases and anti-aging interventions, providing valuable insights into underlying mechanisms and therapeutic avenues for promoting healthy aging.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"101 ","pages":"Article 102539"},"PeriodicalIF":12.5,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142482789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of alcohol use among U.S. older adults with pain: A scoping review 美国患有疼痛的老年人饮酒的普遍程度：范围综述

IF 12.5 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews

Pub Date : 2024-10-10 DOI: 10.1016/j.arr.2024.102541

Lisa R. LaRowe , Heily Chavez Granados , Lisa L. Philpotts , Ana-Maria Vranceanu , Christine S. Ritchie

The majority of older adults in the United States (U.S.) have been bothered by pain in the past month and over one-third report pain that has persisted or recurred for >3 months (i.e., chronic pain). Accumulating evidence indicates that behavioral factors, such as alcohol use, can influence the impact of pain on health and functioning in older adults. However, most studies exploring the prevalence of alcohol use among individuals with pain have not focused on older adults, specifically. Therefore, the goal of this scoping review was to examine what is known about the prevalence of alcohol use in older adults with pain. Relevant articles published prior to April 2024 were identified through a comprehensive search strategy, developed in collaboration with content experts and a medical librarian. A total of 13 studies met inclusion criteria for this paper. Results indicated that 53–64 % of older adults with pain reported alcohol consumption, 11–28 % engaged in hazardous patterns of alcohol use, and 1–10 % had a documented alcohol use diagnosis. Moreover, there is evidence that pain severity is positively associated with likelihood of alcohol consumption among older adults. These findings are worrisome given evidence that alcohol use has been shown to lead to poorer pain outcomes, and that older adults may be at risk for experiencing detrimental alcohol-related effects at comparatively low doses, given unique challenges faced by this population (e.g., high rates of multimorbidity/polypharmacy). Collectively, findings underscore the need for enhanced assessment and treatment of alcohol use in older adults with pain.

在美国，大多数老年人在过去的一个月里都受到过疼痛的困扰，超过三分之一的老年人表示疼痛已经持续或复发了 3 个月（即慢性疼痛）。越来越多的证据表明，饮酒等行为因素会影响疼痛对老年人健康和功能的影响。然而，大多数探讨疼痛患者饮酒普遍性的研究并未特别关注老年人。因此，本次范围界定综述的目的是研究患有疼痛的老年人中酒精使用的普遍性。通过与内容专家和医学图书管理员合作制定的综合搜索策略，确定了 2024 年 4 月之前发表的相关文章。共有 13 项研究符合本文的纳入标准。结果表明，53-64%的疼痛老年人报告有饮酒行为，11-28%的老年人有危险饮酒行为，1-10%的老年人有饮酒诊断记录。此外，有证据表明，疼痛的严重程度与老年人饮酒的可能性呈正相关。这些发现令人担忧，因为有证据表明，饮酒会导致较差的疼痛结果，而且鉴于老年人群面临的独特挑战（如多病/多药高发率），饮酒剂量相对较低的老年人可能会面临酒精相关有害影响的风险。总之，研究结果强调，有必要加强对患有疼痛的老年人饮酒情况的评估和治疗。

{"title":"Prevalence of alcohol use among U.S. older adults with pain: A scoping review","authors":"Lisa R. LaRowe , Heily Chavez Granados , Lisa L. Philpotts , Ana-Maria Vranceanu , Christine S. Ritchie","doi":"10.1016/j.arr.2024.102541","DOIUrl":"10.1016/j.arr.2024.102541","url":null,"abstract":"<div><div>The majority of older adults in the United States (U.S.) have been bothered by pain in the past month and over one-third report pain that has persisted or recurred for >3 months (i.e., chronic pain). Accumulating evidence indicates that behavioral factors, such as alcohol use, can influence the impact of pain on health and functioning in older adults. However, most studies exploring the prevalence of alcohol use among individuals with pain have not focused on older adults, specifically. Therefore, the goal of this scoping review was to examine what is known about the prevalence of alcohol use in older adults with pain. Relevant articles published prior to April 2024 were identified through a comprehensive search strategy, developed in collaboration with content experts and a medical librarian. A total of 13 studies met inclusion criteria for this paper. Results indicated that 53–64 % of older adults with pain reported alcohol consumption, 11–28 % engaged in hazardous patterns of alcohol use, and 1–10 % had a documented alcohol use diagnosis. Moreover, there is evidence that pain severity is positively associated with likelihood of alcohol consumption among older adults. These findings are worrisome given evidence that alcohol use has been shown to lead to poorer pain outcomes, and that older adults may be at risk for experiencing detrimental alcohol-related effects at comparatively low doses, given unique challenges faced by this population (e.g., high rates of multimorbidity/polypharmacy). Collectively, findings underscore the need for enhanced assessment and treatment of alcohol use in older adults with pain.</div></div>","PeriodicalId":55545,"journal":{"name":"Ageing Research Reviews","volume":"101 ","pages":"Article 102541"},"PeriodicalIF":12.5,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142434320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0