Photoacoustics最新文献

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IF 6.8 1区医学 Q1 ENGINEERING, BIOMEDICAL

Photoacoustics

Pub Date : 2026-01-01

引用次数: 0

IF 6.8 1区医学 Q1 ENGINEERING, BIOMEDICAL

Photoacoustics

Pub Date : 2026-01-01

引用次数: 0

IF 6.8 1区医学 Q1 ENGINEERING, BIOMEDICAL

Photoacoustics

Pub Date : 2026-01-01

引用次数: 0

IF 6.8 1区医学 Q1 ENGINEERING, BIOMEDICAL

Photoacoustics

Pub Date : 2026-01-01

引用次数: 0

Vascular graph network for ovarian lesion classification using optical-resolution photoacoustic microscopy 使用光学分辨率光声显微镜进行卵巢病变分类的血管图网络

IF 6.8 1区医学 Q1 ENGINEERING, BIOMEDICAL

Photoacoustics

Pub Date : 2025-12-30 DOI: 10.1016/j.pacs.2025.100794

Yixiao Lin , Lukai Wang , Ian S. Hagemann , Lindsay M. Kuroki , Brooke E. Sanders , Andrea R. Hagemann , Cary Siegel , Matthew A. Powell , Quing Zhu

Diagnosing ovarian lesions is challenging because of their heterogeneous clinical presentations. Some benign ovarian conditions, such as endometriosis, can have features that mimic cancer. We use optical-resolution photoacoustic microscopy (OR-PAM) to study the differences in ovarian vasculature between cancer and various benign conditions. In this study, we converted OR-PAM vascular data into vascular graphs augmented with physical vascular properties. From 94 ovarian specimens, a custom vascular graph network (VGN) was developed to classify each graph as either normal ovary, one of three benign pathologies, or cancer. We demonstrated for the first time that, by leveraging the intrinsic similarity between vascular networks and graph constructs, VGN provides stable predictions from sampling surface areas as small as 3 mm× 0.12 mm. In diagnosing cancer, VGN achieved 79.5 % accuracy and an area under the receiver operating characteristic curve (AUC) of 0.877. Overall, VGN achieved a five-class classification accuracy of 73.4 %.

诊断卵巢病变是具有挑战性的，因为他们的异质临床表现。一些良性卵巢疾病，如子宫内膜异位症，可能具有类似癌症的特征。我们使用光学分辨率光声显微镜（OR-PAM）来研究卵巢血管在癌症和各种良性疾病之间的差异。在这项研究中，我们将OR-PAM血管数据转换成血管图形，并增强了血管的物理特性。从94个卵巢标本中，开发了一个自定义血管图网络（VGN），将每个图分类为正常卵巢、三种良性病理之一或癌症。我们首次证明，通过利用血管网络和图结构之间的内在相似性，VGN可以从小至3 mmx 0.12 mm的采样表面积中提供稳定的预测。在诊断癌症方面，VGN的准确率为79.5 %，受者工作特征曲线下面积（AUC）为0.877。总体而言，VGN实现了73.4 %的五类分类准确率。

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引用次数: 0

Application of a virtual imaging framework for investigating a deep learning-based reconstruction method for 3D quantitative photoacoustic computed tomography 应用虚拟成像框架研究基于深度学习的三维定量光声计算机断层成像重建方法

IF 6.8 1区医学 Q1 ENGINEERING, BIOMEDICAL

Photoacoustics

Pub Date : 2025-12-29 DOI: 10.1016/j.pacs.2025.100792

Refik Mert Cam , Seonyeong Park , Umberto Villa , Mark A. Anastasio

Quantitative photoacoustic computed tomography (qPACT) is a promising imaging modality for estimating physiological parameters such as blood oxygen saturation. However, developing robust qPACT reconstruction methods remains challenging due to computational demands, modeling difficulties, and experimental uncertainties. Learning-based methods have been proposed to address these issues but remain largely unvalidated. Virtual imaging (VI) studies are essential for validating such methods early in development, before proceeding to less-controlled phantom or in vivo studies. Effective VI studies must employ ensembles of stochastically generated numerical phantoms that accurately reflect relevant anatomy and physiology. Yet, most prior VI studies for qPACT relied on overly simplified phantoms. In this work, a realistic VI testbed is employed for the first time to assess a representative 3D learning-based qPACT reconstruction method for breast imaging. The method is evaluated across subject variability and physical factors such as measurement noise and acoustic aberrations, offering insights into its strengths and limitations.

定量光声计算机断层扫描（qPACT）是一种很有前途的成像方式，用于估计生理参数，如血氧饱和度。然而，由于计算需求、建模困难和实验不确定性，开发鲁棒的qPACT重建方法仍然具有挑战性。已经提出了基于学习的方法来解决这些问题，但在很大程度上仍未得到验证。虚拟成像（VI）研究对于在开发早期验证这些方法至关重要，然后再进行较少控制的幻影或体内研究。有效的VI研究必须采用随机生成的数字幻象集合，以准确反映相关的解剖学和生理学。然而，大多数先前的qPACT的VI研究依赖于过于简化的幻影。在这项工作中，首次使用现实的VI测试平台来评估具有代表性的基于3D学习的乳房成像qPACT重建方法。对该方法进行了跨主题可变性和物理因素（如测量噪声和声像差）的评估，从而深入了解其优势和局限性。

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引用次数: 0

Mapping glucose-induced hemodynamics in white fat depots with label-free optoacoustics 用无标签光声学技术测绘白色脂肪库中葡萄糖诱导的血流动力学

IF 6.8 1区医学 Q1 ENGINEERING, BIOMEDICAL

Photoacoustics

Pub Date : 2025-12-23 DOI: 10.1016/j.pacs.2025.100793

Nikolina-Alexia Fasoula , Nikoletta Katsouli , Michael Kallmayer , Vasilis Ntziachristos , Angelos Karlas

Subcutaneous adipose tissue (SAT) hemodynamics is an indicator of cardiometabolic health. Herein, we demonstrate a non-invasive approach for imaging SAT hemodynamics in humans using multispectral optoacoustic tomography (MSOT). We evaluated different SAT depots in individuals with low (< 24 kg/m²) and high (≥ 24 kg/m²) BMI, with each group consisting of 8 participants, during oral glucose challenges. Our results indicate a significant decrease in glucose-induced hyperemic responses within SAT for individuals with higher BMI, at 60 min postprandially. MSOT also revealed that abdominal SAT exhibited a more active hemodynamic status compared to femoral SAT in both groups when compared to baseline measurements. MSOT readouts were further validated against longitudinal blood tests of triglycerides, glucose, lactate, and cholesterol. We introduce MSOT as a new method for studying SAT hemodynamics across multiple depots in a single test, providing invaluable insights into SAT physiology related to BMI fluctuations and general cardiometabolic health.

皮下脂肪组织（SAT）血流动力学是心脏代谢健康的一个指标。在此，我们展示了一种使用多光谱光声断层扫描（MSOT）成像人类SAT血流动力学的非侵入性方法。我们评估了低BMI （< 24 kg/m²）和高BMI（≥24 kg/m²）个体在口服葡萄糖挑战期间的不同SAT水平，每组由8名参与者组成。我们的研究结果表明，在餐后60 min时，BMI较高的个体在SAT中葡萄糖诱导的充血反应显著降低。MSOT还显示，与基线测量相比，两组腹部SAT表现出更活跃的血流动力学状态。MSOT读数与甘油三酯、葡萄糖、乳酸盐和胆固醇的纵向血液测试进一步验证。我们将MSOT作为一种新的方法，在一次测试中跨多个仓库研究SAT血液动力学，为与BMI波动和一般心脏代谢健康相关的SAT生理学提供宝贵的见解。

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引用次数: 0

Detecting parts-per-billion carbon monoxide with an ultra-enhanced near-infrared photoacoustic sensor 用超增强型近红外光声传感器检测十亿分之一的一氧化碳

IF 6.8 1区医学 Q1 ENGINEERING, BIOMEDICAL

Photoacoustics

Pub Date : 2025-12-18 DOI: 10.1016/j.pacs.2025.100790

Yaopeng Cheng , Ting Chen , Ruili Zhang , Sailing He

An ultra-enhanced near-infrared (NIR) photoacoustic gas sensor was developed by integrating three enhancing techniques: (a) boosting the excitation power up to 2 W via a custom-built large-mode erbium doped fiber amplifier (EDFA), (b) exploiting the acoustic resonance amplification of a hyperbolic nonlinear resonator (HNR), and (c) increasing the effective absorption path length by using a near-concentric multipass cavity (MPC) with 20 reflections. A weak CO absorption line at 1566.64 nm with the intensity of 2.074 × 10⁻²³ cm/molecule was selected. The photoacoustic signal was enhanced 396 times. A minimum detection limit (MDL) of 190 ppb at 10 s was achieved and can be improved to be 11.4 ppb according to the Allan analysis, which was comparable to a mid-infrared (MIR) photoacoustic sensor. The ultra-enhanced NIR photoacoustic sensor is a cost-effective solution for the ppb-level trace gas detection, offering a price that is less than one-third that of MIR photoacoustic sensors.

通过集成三种增强技术，开发了一种超增强近红外（NIR）光声气体传感器：(a)通过定制的大模掺铒光纤放大器（EDFA）将激发功率提高到2 W， (b)利用双曲非线性谐振器（HNR）的声共振放大，以及(c)通过使用近同心多通腔（MPC）增加有效吸收路径长度。在1566.64 nm处，选择了一条强度为2.074 × 10−23 cm/分子的弱CO吸收谱线。光声信号增强396倍。在10 s下实现了190 ppb的最小检测限（MDL），根据Allan分析可以提高到11.4 ppb，这与中红外（MIR）光声传感器相当。超增强型近红外光声传感器是一种具有成本效益的解决方案，用于ppb级痕量气体检测，其价格不到MIR光声传感器的三分之一。

引用次数: 0

Dual-comb photoacoustic and photothermal spectroscopy: A comprehensive review 双梳光声光热光谱学综述

IF 6.8 1区医学 Q1 ENGINEERING, BIOMEDICAL

Photoacoustics

Pub Date : 2025-12-12 DOI: 10.1016/j.pacs.2025.100789

Chenghong Zhang , Jacopo Pelini , Stefano Dello Russo , Paolo De Natale , Mario Siciliani de Cumis , Simone Borri

Dual-comb spectroscopy is one of the most powerful techniques for multispecies trace-gas sensing, attracting growing attention in both theoretical and experimental research. Firstly demonstrated and usually applied with direct absorption spectroscopy schemes, the dual-comb approach has been successfully combined with techniques like photoacoustic (PA) and photothermal (PT) spectroscopy in recent years. These techniques have been demonstrated to be particularly attractive because of their wavelength-independent and background-free detection, two key features allowing for the achievement of unprecedented dynamic range and flexibility. The integration of these techniques with dual-comb spectroscopy allows a significant enhancement in spectral resolution and bandwidth while preserving the peculiar features of PA and PT spectroscopy. Since the first proof-of-principle demonstration of dual-comb PA spectroscopy, several solutions based on acoustic transducers and optical cavities have been proposed to enhance the final sensitivity and optimize both detection bandwidth and spectral resolution. Starting from the description of the physical principles behind dual-comb PA and PT spectroscopy, this work presents a comprehensive review of the available state-of-the-art, focusing both on the different experimental setups and on a systematic comparison of the achieved results. Finally, the main challenges and prospects will be discussed, offering insights into potential directions for further innovation.

双梳光谱技术是多组分痕量气体传感技术中最强大的技术之一，在理论和实验研究中都受到越来越多的关注。近年来，双梳方法与光声（PA）、光热（PT）等技术成功结合，首次在直接吸收光谱方案中得到验证并得到应用。这些技术被证明是特别有吸引力的，因为它们的波长无关和无背景检测，两个关键特征允许实现前所未有的动态范围和灵活性。这些技术与双梳光谱的集成可以显著提高光谱分辨率和带宽，同时保留PA和PT光谱的特有特征。自首次双梳PA光谱原理验证以来，已经提出了几种基于声换能器和光学腔的解决方案，以提高最终灵敏度，优化检测带宽和光谱分辨率。从描述双梳PA和PT光谱背后的物理原理开始，这项工作对现有的最先进技术进行了全面的回顾，重点是不同的实验设置和已取得结果的系统比较。最后，将讨论主要挑战和前景，并提供进一步创新的潜在方向。

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引用次数: 0

Design and characterisation of intervertebral disc mimicking phantoms for photoacoustic imaging 用于光声成像的椎间盘模拟幻象的设计和表征

IF 6.8 1区医学 Q1 ENGINEERING, BIOMEDICAL

Photoacoustics

Pub Date : 2025-12-10 DOI: 10.1016/j.pacs.2025.100783

Roman Allais , Valentin Espinas , Antoine Capart , Anabela Da Silva , Olivier Boiron

Photoacoustics has gained momentum as a new medical imaging technique owing to its ability to benefit from good optical contrast and acoustic resolution. To ease transfer into clinical settings and validate the algorithms, calibrated tissue-mimicking materials (TMM) are required. This paper describes a complete photoacoustic characterisation of a line of titanium dioxide (TiO₂) doped agarose hydrogels whose optical absorption (490–835 nm), reduced scattering (590–815 nm), isobaric heat capacity, mass density, speed of sound and acoustic attenuation were quantified for an agarose concentration up to 4% w/w and a TiO₂ concentration ranging from 0.25 to 1 mg/mL. Empirical constitutive laws as a function of the concentrations of the components were derived, enabling the creation of TMM with tailored properties. Results showed that these phantoms are suitable candidates to mimic the photoacoustic properties of various soft tissues including intervertebral discs (IVD). Photoacoustic probings performed on an IVD-mimicking phantom and six healthy porcine discs demonstrated the ability of these TMM to accurately replicate healthy IVD properties; this could serve as a first step towards an application of photoacoustic imaging to quantifying disc degeneration.

光声学作为一种新的医学成像技术，由于其具有良好的光学对比度和声学分辨率而获得了发展势头。为了便于转移到临床环境并验证算法，需要校准的组织模拟材料（TMM）。本文描述了一系列二氧化钛（TiO2）掺杂琼脂糖水凝胶的完整光声表征，其光吸收（490-835 nm），减少散射（590-815 nm），等压热容，质量密度，声速和声衰减在琼脂糖浓度高达4% w/w和TiO2浓度范围为0.25至1 mg/mL时被量化。经验本构定律作为成分浓度的函数被推导出来，使TMM具有量身定制的特性。结果表明，这些幻象是模拟包括椎间盘在内的各种软组织的光声特性的合适候选者。在模拟IVD的假体和六个健康的猪椎间盘上进行的光声探测表明，这些TMM能够准确地复制健康的IVD特性；这可以作为应用光声成像定量椎间盘退变的第一步。

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Photoacoustics

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