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Associations of Faith Community Rejection With Social Support and Health Outcomes Among LGBTQ+ Older Adults. LGBTQ+老年人信仰社区排斥与社会支持和健康结果的关系
IF 3.2 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-04-07 DOI: 10.1093/geronb/gbaf009
Nik M Lampe, Tara McKay

Objectives: Lesbian, gay, bisexual, transgender, and queer (LGBTQ+) older adults have varied experiences with faith communities, ranging from affirmation to religious trauma. We investigate how faith community rejection affects social support and health outcomes among LGBTQ+ older adults in the Southern United States.

Methods: We analyze Wave 1 data from the LGBTQ+ Social Networks, Aging, and Policy Study (QSNAPS), collected between April 2020 and September 2021. This sample included 1,256 LGBTQ+ adults aged 50+ residing in four Southern U.S. states. Bivariate and Poisson regression analyses were conducted to examine associations of LGBTQ-related faith community rejection with social support and health outcomes.

Results: Nearly half (44%) of QSNAPS respondents reported LGBTQ-related faith community rejection. Respondents who reported rejection were more likely to be: transgender or gender diverse (p < .01) and from a minoritized racial/ethnic background (p < .01). Compared with respondents who never experienced faith community rejection, respondents who experienced LGBTQ-related faith community rejection reported a lower prevalence of family support (APR = 0.80; p < .001); higher prevalence of symptoms related to moderate to severe psychological distress (APR = 1.27; p < .001); higher prevalence of poor sleep quality (APR = 1.17; p < .05); and high blood pressure diagnosis (APR = 1.13; p < .05). We also find a marginally statistically significant association between faith community rejection and higher prevalence of symptoms related to subjective cognitive decline (APR = 1.35; p < .10).

Discussion: Experiences of faith community rejection come with substantial social support and health costs for LGBTQ+ older adults. Our findings highlight the importance of integrating faith and promoting inclusion within affirming faith communities for LGBTQ+ aging-related care and prevention.

目的:女同性恋、男同性恋、双性恋、变性人和酷儿(LGBTQ+)老年人在信仰团体中有不同的经历,从肯定到宗教创伤。我们调查了信仰社区拒绝如何影响美国南部LGBTQ+老年人的社会支持和健康结果。方法:我们分析了LGBTQ+社交网络、老龄化和政策研究(QSNAPS)的第一波数据,这些数据收集于2020年4月至2021年9月。该样本包括居住在美国南部四个州的1,256名年龄在50岁以上的LGBTQ+成年人。采用双变量和泊松回归分析来检验与lgbtq相关的信仰社区排斥与社会支持和健康结果的关系。结果:近一半(44%)的QSNAPS受访者表示与lgbtq相关的信仰社区遭到拒绝。报告被拒绝的受访者更有可能是:跨性别者或性别多元化者(p讨论:对LGBTQ+老年人来说,信仰社区被拒绝的经历伴随着大量的社会支持和健康成本。我们的研究结果强调了在肯定信仰社区中整合信仰和促进包容对于LGBTQ+老龄化相关护理和预防的重要性。
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引用次数: 0
Key Predictors of Generativity in Adulthood: A Machine Learning Analysis. 成年期生育能力的关键预测因素:机器学习分析。
IF 4.8 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-03-12 DOI: 10.1093/geronb/gbae204
Mohsen Joshanloo

Objectives: This study aimed to explore a broad range of predictors of generativity in older adults. The study included over 60 predictors across multiple domains, including personality, daily functioning, socioeconomic factors, health status, and mental well-being.

Methods: A random forest machine learning algorithm was used. Data were drawn from the Midlife in the United States (MIDUS) survey.

Results: Social potency, openness, social integration, personal growth, and achievement orientation were the strongest predictors of generativity. Notably, many demographic (e.g., income) and health-related variables (e.g., chronic health conditions) were found to be much less predictive.

Discussion: This study provides new data-driven insights into the nature of generativity. The findings suggest that generativity is more closely associated with eudaimonic and plasticity-related variables (e.g., personal growth and social potency) rather than hedonic and homeostasis-oriented ones (e.g., life satisfaction and emotional stability). This indicates that generativity is an inherently dynamic construct, driven by a desire for exploration, social contribution, and personal growth.

目的:本研究旨在探索老年人生育能力的广泛预测因素。这项研究涵盖了多个领域的60多个预测因素,包括个性、日常功能、社会经济因素、健康状况和心理健康。方法:本研究采用了一种称为随机森林的机器学习算法。数据来自美国中年调查。结果:社会潜能、开放性、社会融合、个人成长和成就取向是生成性的最强预测因子。值得注意的是,许多人口(如收入)和健康相关变量(如慢性健康状况)的预测性要低得多。讨论:这项研究为生成性的本质提供了新的数据驱动的见解。研究结果表明,创造性与幸福感和可塑性相关的变量(如个人成长和社会效力)的关系更密切,而与享乐和自我平衡相关的变量(如生活满意度和情绪稳定性)的关系更密切。这表明,生成是一种内在的动态结构,由探索、社会贡献和个人成长的欲望驱动。
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引用次数: 0
Gender and Educational Trends in Lifetime Risk, Age at Onset, Expectancy, and Survival With Cardiovascular Disease in Finland, 1996-2020. 1996-2020年芬兰心血管疾病终生风险、发病年龄、预期和生存率的性别和教育趋势。
IF 4.8 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-03-12 DOI: 10.1093/geronb/gbaf007
Shubhankar Sharma, Pekka Martikainen, Mikko Myrskylä, Lasse Tarkiainen, Ulla Suulamo

Objectives: Cardiovascular disease (CVD) is the leading cause of mortality globally. Examining trends in CVD burden and associated sociodemographic disparities can contribute to tailoring policies that promote cardiovascular health and narrow health disparities. However, existing studies predominantly focus only on mortality. Therefore, we provide a more comprehensive understanding of CVD trends by studying the diverse aspects of CVD burden: lifetime risk, onset age, CVD-free and CVD life expectancy, and survival with CVD. We focus on the overall Finnish population in 1996-2020, as well as gender and educational disparities.

Methods: We use sociodemographic information from individual-level population registers, which are linked to hospital discharge and Death Registers, on the entire Finnish population aged 40-100 years in five five-year periods in 1996-2020 (N = 2,796,732-3,273,232). We employed multistate models to derive the study metrics.

Results: Overall, CVD's lifetime risk stabilizes at 72% following a rise, with onset age and CVD-free life expectancy increased by 3 years. Although men bear a higher CVD burden, they experience a greater increase in onset age and CVD-free expectancy than women. Educational disparities in CVD-free expectancy persist, exceeding 3.5 years for men and women. Furthermore, survival with CVD has extended by 2.8 years but educational disparities widen.

Discussion: Despite the encouraging CVD trends in the overall population and progress in narrowing gender disparities, there remains considerable room for further improvement. Persistent educational disparities in CVD burden underscore the need for more effective interventions to address enduring inequalities.

目的:心血管疾病(CVD)是全球死亡的主要原因。检查心血管疾病负担的趋势和相关的社会人口差异可有助于制定促进心血管健康和缩小健康差异的政策。然而,现有的研究主要集中在死亡率上。因此,我们通过研究CVD负担的各个方面:终生风险、发病年龄、无CVD和CVD预期寿命以及CVD生存期,对CVD趋势有了更全面的了解。我们关注1996-2020年的芬兰总人口,以及性别和教育差异。方法:我们使用来自个人层面人口登记的社会人口学信息,这些信息与出院和死亡登记有关,涉及1996-2020年五个五年期间40-100岁的芬兰全部人口(N=2,796,732-3,273,232)。我们采用多状态模型来推导研究指标。结果:总体而言,心血管疾病的终生风险稳定在72%,发病年龄和无心血管疾病预期寿命增加3年。尽管男性承受着更高的心血管疾病负担,但他们的发病年龄和无心血管疾病预期比女性增加得更多。无心血管疾病预期方面的教育差异仍然存在,男性和女性超过3.5岁。此外,心血管疾病患者的生存期延长了2.8年,但教育程度的差异扩大了。讨论:尽管总体人口中心血管疾病的趋势令人鼓舞,并且在缩小性别差异方面取得了进展,但仍有很大的改进空间。心血管疾病负担方面持续存在的教育差异突出表明,需要采取更有效的干预措施来解决持续存在的不平等现象。
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引用次数: 0
Employment Responses to a Partner's Disability Onset ("Care Shocks"): Do Working Conditions Matter? 雇主对伴侣残疾的反应(护理冲击):工作条件重要吗?
IF 4.8 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-03-12 DOI: 10.1093/geronb/gbae208
Constance Beaufils, Ben Baumberg Geiger, Karen Glaser

Objectives: This study examines employment responses to a partner's disability onset and how this is moderated by working conditions: job satisfaction and psychosocial job demands.

Methods: We use longitudinal nationally representative data from the English Longitudinal Study of Aging. Following the health shock literature, we identify individuals whose partners report the onset of difficulties in activities of daily living (ADL) or instrumental activities of daily living (IADL) between 2 waves (n = 1,020) as experiencing a "care shock." We combine coarsened exact matching and entropy balancing, and logistic modeling to estimate the impact of such a "care shock" on the probability of leaving paid work, working part-time, changing jobs, or looking for a new job. We also explore the moderating effect of gender and working conditions (i.e., job demands and job satisfaction) on the impact of a "care shock" on work transitions.

Results: Our findings show that "care shocks" significantly increase individuals' likelihood of leaving paid work. This effect is moderated by job demands and job satisfaction. Individuals who report high job demands and job dissatisfaction before the care shock are significantly more likely to leave paid work. In contrast, those with low job demands or job satisfaction show no significant difference in their likelihood of leaving paid work.

Discussion: Our study highlights the role of working conditions in moderating the impact of care shocks on paid work. It informs workplace policies, as our results suggest that adapting working conditions may facilitate participation in the labor market in late career stages.

目的:本研究考察了就业对伴侣残疾发病的反应,以及工作条件:工作满意度和心理社会工作需求如何调节这种反应。方法:我们使用英国老龄化纵向研究中具有全国代表性的纵向数据。根据健康休克文献,我们确定伴侣报告在两个波(n=1,020)之间出现日常生活活动(ADL)或工具性日常生活活动(IADL)困难的个体为经历“护理休克”。我们结合了粗糙的精确匹配和熵平衡,以及逻辑模型来估计这种“关怀冲击”对离开带薪工作、兼职工作、换工作或寻找新工作的概率的影响。我们还探讨了性别和工作条件(即工作需求和工作满意度)对“护理冲击”对工作过渡的影响的调节作用。结果:我们的研究结果表明,“护理冲击”显著增加了个人离开带薪工作的可能性。这种效应受工作需求和工作满意度的调节。在护理休克之前报告高工作要求和工作不满的个人更有可能离开带薪工作。相比之下,那些工作要求或工作满意度较低的人在离开带薪工作的可能性方面没有显着差异。讨论:我们的研究强调了工作条件在缓和护理冲击对带薪工作的影响中的作用。它为工作场所政策提供了信息,因为我们的研究结果表明,适应工作条件可能有助于在职业生涯后期参与劳动力市场。
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引用次数: 0
Resilience Factors Affecting Long-Term Trajectories of Depressive Symptoms in the Aftermath of the Great East Japan Earthquake and Tsunami Among Older Adults. 影响东日本大地震和海啸后老年人抑郁症状长期轨迹的复原力因素。
IF 3.2 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-03-12 DOI: 10.1093/geronb/gbae182
Aki Yazawa, Xiaoyu Li, Koichiro Shiba, Sakurako S Okuzono, Hiroyuki Hikichi, Jun Aida, Katsunori Kondo, Ichiro Kawachi

Objectives: We examined long-term trajectories of depressive symptoms among older adults following exposure to the 2011 Great East Japan Earthquake and Tsunami. We further characterized the pre- and post-disaster social relationship factors that predicted membership in each trajectory group.

Methods: Data from 4 time points (including pre-disaster data) were used to analyze the depression trajectories of 2,033 survivors through a group-based trajectory model. Multinomial logistic analysis was used to investigate the social relationship factors (i.e., social interactions with neighbors, social support, social participation, and social cohesion) that predicted membership to each trajectory group.

Results: Five distinct trajectories of depressive symptoms were identified; stably not depressed (12.4%), increased after the disaster (14.2%), decreased after the disaster (8.8%), persistent mild depressive symptoms (28.1%), and persistent severe depressive symptoms (36.5%). Compared to those who were stably not depressed, those who experienced an increase in symptoms were more likely to experience housing damage and not to participate in social activities. Compared to those who were stably mildly depressed, those who experienced a decrease in symptoms had higher pre-disaster social interactions with neighbors as well as higher post-disaster social support. Adults with persistent severe symptoms were physically, psychologically, and socially vulnerable preceding the disaster.

Discussion: The study revealed the heterogeneity of older adults experiencing depressive symptoms in the wake of major disaster. Those who experienced increased symptoms after the disaster showed a chronic rather than temporary rise, while those with pre-disaster depressive symptoms showed sustained symptoms regardless of disaster-related trauma.

研究目的我们研究了2011年东日本大地震和海啸后老年人抑郁症状的长期轨迹。我们进一步研究了预测各轨迹组别成员的灾前和灾后社会关系因素:我们利用四个时间点的数据(包括灾前数据),通过基于群体的轨迹模型分析了 2033 名幸存者的抑郁轨迹。多项式逻辑分析法用于研究预测各轨迹群体成员的社会关系因素(即与邻居的社会交往、社会支持、社会参与和社会凝聚力):研究发现了五种不同的抑郁症状轨迹:稳定未患抑郁症(12.4%)、灾后抑郁症状加重(14.2%)、灾后抑郁症状减轻(8.8%)、持续轻度抑郁症状(28.1%)和持续重度抑郁症状(36.5%)。与稳定的非抑郁症患者相比,症状加重的患者更有可能住房受损,也更有可能不参加社交活动。与稳定的轻度抑郁症患者相比,症状减轻的患者在灾前与邻居的社交互动较多,灾后的社会支持也较多。症状持续严重的成年人在灾前在身体、心理和社会方面都很脆弱:该研究揭示了老年人在重大灾难后出现抑郁症状的异质性。那些在灾后症状加重的人表现出的是慢性而非暂时性的加重,而那些在灾前就有抑郁症状的人则表现出持续的症状,与灾难相关的创伤无关。
{"title":"Resilience Factors Affecting Long-Term Trajectories of Depressive Symptoms in the Aftermath of the Great East Japan Earthquake and Tsunami Among Older Adults.","authors":"Aki Yazawa, Xiaoyu Li, Koichiro Shiba, Sakurako S Okuzono, Hiroyuki Hikichi, Jun Aida, Katsunori Kondo, Ichiro Kawachi","doi":"10.1093/geronb/gbae182","DOIUrl":"10.1093/geronb/gbae182","url":null,"abstract":"<p><strong>Objectives: </strong>We examined long-term trajectories of depressive symptoms among older adults following exposure to the 2011 Great East Japan Earthquake and Tsunami. We further characterized the pre- and post-disaster social relationship factors that predicted membership in each trajectory group.</p><p><strong>Methods: </strong>Data from 4 time points (including pre-disaster data) were used to analyze the depression trajectories of 2,033 survivors through a group-based trajectory model. Multinomial logistic analysis was used to investigate the social relationship factors (i.e., social interactions with neighbors, social support, social participation, and social cohesion) that predicted membership to each trajectory group.</p><p><strong>Results: </strong>Five distinct trajectories of depressive symptoms were identified; stably not depressed (12.4%), increased after the disaster (14.2%), decreased after the disaster (8.8%), persistent mild depressive symptoms (28.1%), and persistent severe depressive symptoms (36.5%). Compared to those who were stably not depressed, those who experienced an increase in symptoms were more likely to experience housing damage and not to participate in social activities. Compared to those who were stably mildly depressed, those who experienced a decrease in symptoms had higher pre-disaster social interactions with neighbors as well as higher post-disaster social support. Adults with persistent severe symptoms were physically, psychologically, and socially vulnerable preceding the disaster.</p><p><strong>Discussion: </strong>The study revealed the heterogeneity of older adults experiencing depressive symptoms in the wake of major disaster. Those who experienced increased symptoms after the disaster showed a chronic rather than temporary rise, while those with pre-disaster depressive symptoms showed sustained symptoms regardless of disaster-related trauma.</p>","PeriodicalId":56111,"journal":{"name":"Journals of Gerontology Series B-Psychological Sciences and Social Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11898207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mindfulness Interventions in Older Adults for Mental Health and Well-Being: A Meta-Analysis. 正念干预对老年人心理健康和幸福的影响:一项荟萃分析。
IF 4.8 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-03-12 DOI: 10.1093/geronb/gbae205
Paul Verhaeghen, Shelley N Aikman, Grazia Mirabito

Objectives: Mindfulness interventions are consistently associated with beneficial effects in younger adults. In this meta-analysis, we seek to quantify the effectiveness of mindfulness interventions for the mental health and well-being of older adults.

Methods: We include 46 studies that implemented a mindfulness intervention (MBSR = 20; MBCT = 9; ad hoc protocol = 17) with older adults (samples with an average age of 60 or older; healthy adults = 20; adults with underlying symptoms = 26), examining a wide range of outcome measures (e.g., stress, quality of life, sleep).

Results: Mindfulness interventions in older adults yielded an estimated Hedges' g of 0.25. Moderator analyses revealed three significant effects. Type of intervention mattered, with the effect size for MBSR not significantly different from zero (Hedges' g = 0.12) while the effect sizes for MBCT (Hedges' g = 0.33) and "other" interventions (Hedges' g = 0.36) were. Outcome measure mattered, with significant beneficial effect sizes for mental functioning (Hedges' g = 0.59), depression (Hedges' g = 0.35), sleep (Hedges' g = 0.39), anxiety (Hedges' g = 0.32), "other" (Hedges' g = 0.24), stress (Hedges' g = 0.22) and mindfulness (Hedges' g = 0.23). Finally, whether the outcome was targeted (e.g., measures of depression in a population suffering from major depressive disorder) mattered: variables that measured targeted outcomes yielded stronger effects (Hedges' g = 0.30).

Discussion: Mindfulness interventions with older adults are effective, but modestly so. The extant literature is limited by reliance on modified interventions that have not been evaluated for effectiveness.

目的:正念干预始终与年轻人的有益效果相关。在本荟萃分析中,我们试图量化正念干预对老年人心理健康和福祉的有效性。方法:我们纳入了46项实施正念干预的研究(MBSR = 20;MBCT = 9;AD hoc方案= 17)老年人(样本平均年龄为60岁或以上;健康成人= 20;有潜在症状的成人= 26),检查了广泛的结果测量(例如,压力、生活质量、睡眠)。结果:正念干预在老年人中产生的hedge ' g估计为0.25。调节因子分析显示了三个显著的影响。干预类型很重要,MBSR的效应值与零没有显著差异(Hedges' g = 0.12),而MBCT (Hedges' g = 0.33)和“其他”干预(Hedges' g = 0.36)的效应值与零没有显著差异。结果测量很重要,心理功能(赫奇斯的g = 0.59)、抑郁(赫奇斯的g = 0.35)、睡眠(赫奇斯的g = 0.39)、焦虑(赫奇斯的g = 0.32)、“其他”(赫奇斯的g = 0.24)、压力(赫奇斯的g = 0.22)和正念(赫奇斯的g = 0.23)的有益效应显著。最后,结果是否有针对性(例如,在患有重度抑郁症的人群中测量抑郁症)很重要:测量目标结果的变量产生了更强的效果(赫奇斯的g = 0.30)。讨论:正念干预对老年人是有效的,但效果有限。现有的文献是有限的,依赖于改良的干预措施,没有评估其有效性。
{"title":"Mindfulness Interventions in Older Adults for Mental Health and Well-Being: A Meta-Analysis.","authors":"Paul Verhaeghen, Shelley N Aikman, Grazia Mirabito","doi":"10.1093/geronb/gbae205","DOIUrl":"10.1093/geronb/gbae205","url":null,"abstract":"<p><strong>Objectives: </strong>Mindfulness interventions are consistently associated with beneficial effects in younger adults. In this meta-analysis, we seek to quantify the effectiveness of mindfulness interventions for the mental health and well-being of older adults.</p><p><strong>Methods: </strong>We include 46 studies that implemented a mindfulness intervention (MBSR = 20; MBCT = 9; ad hoc protocol = 17) with older adults (samples with an average age of 60 or older; healthy adults = 20; adults with underlying symptoms = 26), examining a wide range of outcome measures (e.g., stress, quality of life, sleep).</p><p><strong>Results: </strong>Mindfulness interventions in older adults yielded an estimated Hedges' g of 0.25. Moderator analyses revealed three significant effects. Type of intervention mattered, with the effect size for MBSR not significantly different from zero (Hedges' g = 0.12) while the effect sizes for MBCT (Hedges' g = 0.33) and \"other\" interventions (Hedges' g = 0.36) were. Outcome measure mattered, with significant beneficial effect sizes for mental functioning (Hedges' g = 0.59), depression (Hedges' g = 0.35), sleep (Hedges' g = 0.39), anxiety (Hedges' g = 0.32), \"other\" (Hedges' g = 0.24), stress (Hedges' g = 0.22) and mindfulness (Hedges' g = 0.23). Finally, whether the outcome was targeted (e.g., measures of depression in a population suffering from major depressive disorder) mattered: variables that measured targeted outcomes yielded stronger effects (Hedges' g = 0.30).</p><p><strong>Discussion: </strong>Mindfulness interventions with older adults are effective, but modestly so. The extant literature is limited by reliance on modified interventions that have not been evaluated for effectiveness.</p>","PeriodicalId":56111,"journal":{"name":"Journals of Gerontology Series B-Psychological Sciences and Social Sciences","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Loneliness and Biomarkers of Alzheimer's Disease, Axonal Damage, and Astrogliosis: A Coordinated Analysis of Two Longitudinal Cohorts. 阿尔茨海默病、轴突损伤和星形胶质增生的孤独和生物标志物:两个纵向队列的协调分析。
IF 3.2 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-03-12 DOI: 10.1093/geronb/gbaf006
Antonio Terracciano, Keenan A Walker, Yang An, Murat Bilgel, Angelina R Sutin, Martina Luchetti, Selin Karakose, Yannick Stephan, Kaj Blennow, Henrik Zetterberg, Nicholas J Ashton, Thomas K Karikari, Przemysław R Kac, Abhay R Moghekar, Madhav Thambisetty, Luigi Ferrucci, Susan M Resnick

Objectives: Loneliness is associated with an elevated risk of dementia. There is mixed evidence from imaging studies on whether loneliness is associated with neuropathology in dementia-free adults. This study tests whether loneliness is associated with plasma neurobiomarkers of amyloid (Aβ42/Aβ40), phosphorylated tau 181 (pTau181), neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) and imaging measures of amyloid and tau.

Methods: Participants were cognitively unimpaired older adults from the Baltimore Longitudinal Study on Aging (BLSA; N = 1,028 individuals and up to 2,277 neurobiomarker measurements; Baseline mean age = 66, SD = 15 years) and the UK Biobank (N = 1,263 individuals and up to 2,526 neurobiomarker measurements; Baseline mean age = 60, SD = 7 years). Single-item measures of loneliness and the Quanterix Single Molecule Array assays were used in both samples. In a subset of BLSA participants, positron emission tomography (PET) was used to assess cerebral amyloid burden (n = 220) and tau in the entorhinal cortex (n = 102).

Results: In both samples and meta-analyses, loneliness was unrelated to plasma measures of Aβ42/Aβ40, pTau181, NfL, and GFAP. Changes in loneliness were also unrelated to changes in the plasma neurobiomarkers, and no consistent evidence of moderation by age, sex, or APOE ε4 allele was found. Loneliness was also unrelated to PET-based measures of amyloid and tau.

Discussion: This study found no associations between loneliness and measures of Alzheimer's disease pathology, axonal damage, or astrogliosis.

目的:孤独与痴呆风险升高有关。在无痴呆的成年人中,关于孤独是否与神经病理学相关的影像学研究证据不一。本研究测试了孤独感是否与淀粉样蛋白(Aβ42/Aβ40)、磷酸化tau 181 (pTau181)、神经丝轻链(NfL)和胶质纤维酸性蛋白(GFAP)的血浆神经生物标志物以及淀粉样蛋白和tau的成像指标有关。方法:参与者是来自巴尔的摩老龄化纵向研究(BLSA;N= 1028个个体和多达2277个神经生物标志物测量;基线平均年龄=66岁,SD=15岁)和UK Biobank (N=1,263个人和多达2,526个神经生物标志物测量;基线平均年龄=60岁,SD=7岁)。在两个样本中使用了孤独感的单项测量和Quanterix单分子阵列测定。在一部分BLSA参与者中,正电子发射断层扫描(PET)用于评估大脑淀粉样蛋白负荷(n=220)和内嗅皮层的tau蛋白(n=102)。结果:在样本和荟萃分析中,孤独感与血浆中a- β42/ a- β40、pTau181、NfL和GFAP的测定无关。孤独感的变化也与血浆神经生物标志物的变化无关,并且没有发现与年龄、性别或APOE ε4等位基因有关的一致证据。孤独感也与基于PET的淀粉样蛋白和tau蛋白测量无关。讨论:本研究未发现孤独感与阿尔茨海默病病理、轴突损伤或星形胶质细胞增生之间存在关联。
{"title":"Loneliness and Biomarkers of Alzheimer's Disease, Axonal Damage, and Astrogliosis: A Coordinated Analysis of Two Longitudinal Cohorts.","authors":"Antonio Terracciano, Keenan A Walker, Yang An, Murat Bilgel, Angelina R Sutin, Martina Luchetti, Selin Karakose, Yannick Stephan, Kaj Blennow, Henrik Zetterberg, Nicholas J Ashton, Thomas K Karikari, Przemysław R Kac, Abhay R Moghekar, Madhav Thambisetty, Luigi Ferrucci, Susan M Resnick","doi":"10.1093/geronb/gbaf006","DOIUrl":"10.1093/geronb/gbaf006","url":null,"abstract":"<p><strong>Objectives: </strong>Loneliness is associated with an elevated risk of dementia. There is mixed evidence from imaging studies on whether loneliness is associated with neuropathology in dementia-free adults. This study tests whether loneliness is associated with plasma neurobiomarkers of amyloid (Aβ42/Aβ40), phosphorylated tau 181 (pTau181), neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) and imaging measures of amyloid and tau.</p><p><strong>Methods: </strong>Participants were cognitively unimpaired older adults from the Baltimore Longitudinal Study on Aging (BLSA; N = 1,028 individuals and up to 2,277 neurobiomarker measurements; Baseline mean age = 66, SD = 15 years) and the UK Biobank (N = 1,263 individuals and up to 2,526 neurobiomarker measurements; Baseline mean age = 60, SD = 7 years). Single-item measures of loneliness and the Quanterix Single Molecule Array assays were used in both samples. In a subset of BLSA participants, positron emission tomography (PET) was used to assess cerebral amyloid burden (n = 220) and tau in the entorhinal cortex (n = 102).</p><p><strong>Results: </strong>In both samples and meta-analyses, loneliness was unrelated to plasma measures of Aβ42/Aβ40, pTau181, NfL, and GFAP. Changes in loneliness were also unrelated to changes in the plasma neurobiomarkers, and no consistent evidence of moderation by age, sex, or APOE ε4 allele was found. Loneliness was also unrelated to PET-based measures of amyloid and tau.</p><p><strong>Discussion: </strong>This study found no associations between loneliness and measures of Alzheimer's disease pathology, axonal damage, or astrogliosis.</p>","PeriodicalId":56111,"journal":{"name":"Journals of Gerontology Series B-Psychological Sciences and Social Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11898208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Childhood Adversities, Midlife Health, and Elder Abuse Victimization: A Longitudinal Analysis Based on Cumulative Disadvantage Theory. 修正:童年逆境、中年健康与老年虐待受害:基于累积劣势理论的纵向分析。
IF 4.8 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-03-12 DOI: 10.1093/geronb/gbaf047
{"title":"Correction to: Childhood Adversities, Midlife Health, and Elder Abuse Victimization: A Longitudinal Analysis Based on Cumulative Disadvantage Theory.","authors":"","doi":"10.1093/geronb/gbaf047","DOIUrl":"https://doi.org/10.1093/geronb/gbaf047","url":null,"abstract":"","PeriodicalId":56111,"journal":{"name":"Journals of Gerontology Series B-Psychological Sciences and Social Sciences","volume":"80 4","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Childhood Adversity on Late-Life Cognition in Older Puerto Rican Adults. 童年逆境对波多黎各老年人晚年认知的影响。
IF 3.2 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-03-12 DOI: 10.1093/geronb/gbae199
James Lian, Michael Crowe, Kaarin J Anstey, Kim M Kiely, Ana Luisa Dávila, Ross Andel

Objectives: This study examined the association between childhood adversity and late-life cognitive outcomes among older Puerto Rican adults.

Methods: Data were from the Puerto Rican Elder: Health Conditions study, a population-based cohort of 3,713 older Puerto Rican adults (mean age 72.5 years; 60% female). Adverse childhood experiences were categorized into four factors: economic hardship, parental illiteracy, childhood illness, and neighborhood disadvantage. Cognition was assessed with the Mini-Mental Cabán (MMC). For our analyses, cognitive impairment was defined as scoring 1.5 standard deviations below the expected score, adjusted for age, sex, education, and reading ability. Ordinal logistic regression (baseline) and generalized linear mixed models (all 3 waves) analyzed MMC scores; generalized estimating equations assessed incident cognitive impairment (Waves 2 and 3).

Results: All four adversity factors were associated with poorer MMC scores at baseline. Parental illiteracy (β = -0.35, p < .001) and neighborhood disadvantage (β = -0.27, p < .001) showed stronger associations than economic hardship (β = -0.10, p = .003) and childhood illness (β = -0.21, p < .001). No factors were significantly related to changes in cognitive scores over time. Depressive symptoms and self-rated health partially mediated cross-sectional relationships, with depressive symptoms showing a stronger effect. All adversity factors except economic hardship were linked to baseline cognitive impairment (OR = 1.42 parent illiteracy, OR = 1.24 childhood illness, OR = 1.82 neighborhood disadvantage, p < .05). Only neighborhood disadvantage was associated with incident cognitive impairment (OR = 1.19, p = .003).

Discussion: This study highlights the lasting effect of childhood adversity on late-life cognitive health among older Puerto Ricans, suggesting that addressing early adversity may promote cognitive health later in life.

研究目的本研究探讨了波多黎各老年人童年逆境与晚年认知结果之间的关系:数据来自 PREHCO 研究,这是一项以人口为基础的队列研究,共有 3,713 名波多黎各老年人参加(平均年龄 72.5 岁;60% 为女性)。童年不良经历 (ACE) 被分为四个因素:经济困难、父母不识字、童年疾病和邻里关系不利。认知能力通过小型智力测验(MMC)进行评估。在我们的分析中,认知障碍被定义为低于预期得分 1.5 SD,并对年龄、性别、教育程度和阅读能力进行了调整。顺序逻辑回归(基线)和广义线性混合模型(所有三个波次)分析了MMC得分;广义估计方程评估了认知障碍事件(第2波次和第3波次):所有四个逆境因素都与基线时较低的MMC得分有关。父母不识字(β=-0.35,p讨论:这项研究强调了童年逆境对波多黎各老年人晚年认知健康的持久影响,表明解决早期逆境问题可促进晚年认知健康。
{"title":"Impact of Childhood Adversity on Late-Life Cognition in Older Puerto Rican Adults.","authors":"James Lian, Michael Crowe, Kaarin J Anstey, Kim M Kiely, Ana Luisa Dávila, Ross Andel","doi":"10.1093/geronb/gbae199","DOIUrl":"10.1093/geronb/gbae199","url":null,"abstract":"<p><strong>Objectives: </strong>This study examined the association between childhood adversity and late-life cognitive outcomes among older Puerto Rican adults.</p><p><strong>Methods: </strong>Data were from the Puerto Rican Elder: Health Conditions study, a population-based cohort of 3,713 older Puerto Rican adults (mean age 72.5 years; 60% female). Adverse childhood experiences were categorized into four factors: economic hardship, parental illiteracy, childhood illness, and neighborhood disadvantage. Cognition was assessed with the Mini-Mental Cabán (MMC). For our analyses, cognitive impairment was defined as scoring 1.5 standard deviations below the expected score, adjusted for age, sex, education, and reading ability. Ordinal logistic regression (baseline) and generalized linear mixed models (all 3 waves) analyzed MMC scores; generalized estimating equations assessed incident cognitive impairment (Waves 2 and 3).</p><p><strong>Results: </strong>All four adversity factors were associated with poorer MMC scores at baseline. Parental illiteracy (β = -0.35, p < .001) and neighborhood disadvantage (β = -0.27, p < .001) showed stronger associations than economic hardship (β = -0.10, p = .003) and childhood illness (β = -0.21, p < .001). No factors were significantly related to changes in cognitive scores over time. Depressive symptoms and self-rated health partially mediated cross-sectional relationships, with depressive symptoms showing a stronger effect. All adversity factors except economic hardship were linked to baseline cognitive impairment (OR = 1.42 parent illiteracy, OR = 1.24 childhood illness, OR = 1.82 neighborhood disadvantage, p < .05). Only neighborhood disadvantage was associated with incident cognitive impairment (OR = 1.19, p = .003).</p><p><strong>Discussion: </strong>This study highlights the lasting effect of childhood adversity on late-life cognitive health among older Puerto Ricans, suggesting that addressing early adversity may promote cognitive health later in life.</p>","PeriodicalId":56111,"journal":{"name":"Journals of Gerontology Series B-Psychological Sciences and Social Sciences","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Social Connectedness in Older Adults: The Potential of Social Internet Use to Maintain a Strong and Stable Personal Network. 老年人的社会联系:使用社交网络维持强大而稳定的个人网络的潜力。
IF 4.8 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-03-12 DOI: 10.1093/geronb/gbaf014
Jeroen H M Janssen, Theo G van Tilburg, Erik J van Ingen, Rense Corten, G M E E Geeske Peeters

Objectives: Maintaining a strong social network in later life can be challenging due to limited resources, life events, and changes in health. Social internet use provides an accessible way for communication that is less susceptible to age-related challenges. Although social internet use is increasingly used by older adults, we do not know how social internet use shapes older adults' offline networks. The purpose of this study is to examine whether social internet use can help maintain strong social relationships.

Methods: We used data from 3 waves (2012-2013, 2015-2016, and 2018-2019) of the Longitudinal Aging Study Amsterdam. Our sample included 2,266 older adults aged 55-99 (mean = 68.2 years, 54% female). We included the frequency of social internet use and computed personal network size, contact frequency, and the number of continued, gained, and lost ties over time. Hybrid models were applied to disentangle between within- and between-person associations.

Results: More frequent social internet users had significantly larger personal networks and, relative to the previous wave, more continued and gained network ties, compared to less frequent social internet users. A within-person increase in social internet use over time was associated with more continued and gained ties.

Discussion: Social internet use may help maintain a strong and stable network, which is important for social connectedness in later life. It allows for additional interaction opportunities, as well as network maintenance and growth. Social internet use thus proves to be a valuable addition to the social interaction resources of older adults.

目的:由于有限的资源、生活事件和健康状况的变化,在以后的生活中维持一个强大的社会网络可能是具有挑战性的。社交网络的使用提供了一种方便的沟通方式,不太容易受到年龄相关挑战的影响。虽然老年人越来越多地使用社交网络,但我们不知道社交网络的使用如何影响老年人的线下网络。本研究的目的是检验社交网络的使用是否有助于维持牢固的社会关系。方法:我们使用了阿姆斯特丹纵向老龄化研究的三波(2012-2013年、2015-2016年和2018-2019年)数据。我们的样本包括2266名年龄在55-99岁之间的老年人(平均68.2岁,54%为女性)。我们将社交网络使用的频率和计算的个人网络规模、联系频率以及随着时间的推移持续、获得和失去的联系的数量包括在内。混合模型被应用于理清人与人之间的联系。结果:与前一波相比,频繁使用社交网络的用户拥有更大的个人网络,与不频繁使用社交网络的用户相比,他们拥有更多持续和获得的网络联系。随着时间的推移,个人社交网络使用的增加与更持久和获得的联系有关。讨论:社交网络的使用可能有助于维持一个强大而稳定的网络,这对以后的社会联系很重要。它允许额外的交互机会,以及网络维护和增长。因此,社交网络的使用被证明是老年人社会互动资源的一个有价值的补充。
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Journals of Gerontology Series B-Psychological Sciences and Social Sciences
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