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On a subdiffusive tumour growth model with fractional time derivative 一个具有分数时间导数的次扩散肿瘤生长模型
IF 1.2 4区 数学 Q3 Mathematics Pub Date : 2021-06-01 DOI: 10.1093/imamat/hxab009
Marvin Fritz;Christina Kuttler;Mabel L Rajendran;Barbara Wohlmuth;Laura Scarabosio
In this work, we present and analyse a system of coupled partial differential equations, which models tumour growth under the influence of subdiffusion, mechanical effects, nutrient supply and chemotherapy. The subdiffusion of the system is modelled by a time fractional derivative in the equation governing the volume fraction of the tumour cells. The mass densities of the nutrients and the chemotherapeutic agents are modelled by reaction diffusion equations. We prove the existence and uniqueness of a weak solution to the model via the Faedo–Galerkin method and the application of appropriate compactness theorems. Lastly, we propose a fully discretized system and illustrate the effects of the fractional derivative and the influence of the fractional parameter in numerical examples.
在这项工作中,我们提出并分析了一个耦合偏微分方程组,该方程组模拟了在亚扩散、机械效应、营养供应和化疗影响下的肿瘤生长。系统的亚扩散通过控制肿瘤细胞体积分数的方程中的时间分数导数来建模。营养物质和化学治疗剂的质量密度通过反应扩散方程进行建模。通过Faedo–Galerkin方法和适当紧性定理的应用,证明了该模型弱解的存在性和唯一性。最后,我们提出了一个完全离散化的系统,并在数值例子中说明了分数导数的影响和分数参数的影响。
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引用次数: 15
The maximum likelihood ensemble filter for computational flame and fluid dynamics 计算火焰与流体动力学的最大似然集合滤波器
IF 1.2 4区 数学 Q3 Mathematics Pub Date : 2021-06-01 DOI: 10.1093/imamat/hxab010
Yijun Wang;Stephen Guzik;Milija Zupanski;Xinfeng Gao
The numerical solution of partial differential equations that govern fluid dynamics with turbulence and combustion is challenging due to the multiscale nature of the dynamical system and the need to resolve small-scale physical features. In addition, the uncertainties in the dynamical system, including those in the physical models and parameters, initial and boundary conditions and numerical methods, impact the computational fluid dynamics (CFD) prediction of turbulence and chemical reactions. To improve the CFD prediction, this study focuses on the development and application of a maximum likelihood ensemble filter (MLEF), an ensemble-based data assimilation (DA), for flows featuring combustion and/or turbulence. MLEF finds the optimal analysis and its uncertainty by maximizing the posterior probability density function. The novelty of the study lies in the combination of advanced DA and CFD methods for a new comprehensive application to predict engineering fluid dynamics. The study combines important aspects, including an ensemble-based DA with analysis and uncertainty estimation, an augmented control vector that simultaneously adjusts initial conditions and model empirical parameters and an application of DA to CFD modeling of combustion and flows with complex geometry. The DA performance is validated by a turbulent Couette flow. The new CFD–DA system is then applied to solve the time-evolving shear-layer mixing with methane-air combustion and the turbulent flow over a bluff-body geometry. Results demonstrate the improvement of estimates of model parameters and the uncertainty reduction in initial conditions (ICs) for CFD modeling of flames and flows by the MLEF method.
由于动力学系统的多尺度性质和解决小尺度物理特征的需要,控制湍流和燃烧流体动力学的偏微分方程的数值求解具有挑战性。此外,动力学系统中的不确定性,包括物理模型和参数、初始和边界条件以及数值方法中的不确定因素,影响湍流和化学反应的计算流体动力学(CFD)预测。为了改进CFD预测,本研究重点开发和应用最大似然集合滤波器(MLEF),一种基于集合的数据同化(DA),用于以燃烧和/或湍流为特征的流动。MLEF通过最大化后验概率密度函数来找到最优分析及其不确定性。该研究的新颖之处在于将先进的DA和CFD方法相结合,为预测工程流体动力学提供了新的综合应用。该研究结合了重要方面,包括基于集成的DA与分析和不确定性估计,同时调整初始条件和模型经验参数的增强控制向量,以及DA在复杂几何形状的燃烧和流动CFD建模中的应用。通过湍流Couette流验证了DA性能。然后,将新的CFD–DA系统应用于求解随时间变化的剪切层与甲烷-空气燃烧的混合以及钝体几何形状上的湍流。结果表明,使用MLEF方法对火焰和流动进行CFD建模,可以改进模型参数的估计,并降低初始条件(IC)的不确定性。
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引用次数: 1
Stability of Fixed Points in an Approximate Solution of the Spring-mass Running Model 弹簧质量运行模型近似解中不动点的稳定性
IF 1.2 4区 数学 Q3 Mathematics Pub Date : 2021-05-15 DOI: 10.21203/RS.3.RS-563354/V1
Zofia Wr'oblewska, P. Kowalczyk, Lukasz Plociniczak
We consider a classical spring-mass model of human running which is built upon an inverted elastic pendulum. Based on our previous results concerning asymptotic solutions for large spring constant (or small angle of attack), we construct analytical approximations of solutions in the considered model. The model itself consists of two sets of differential equations - one set describes the motion of the centre of mass of a runner in contact with the ground (support phase), and the second set describes the phase of no contact with the ground (flight phase). By appropriately concatenating asymptotic solutions for the two phases we are able to reduce the dynamics to a one-dimensional apex to apex return map. We find sufficient conditions for this map to have a unique stable fixed point. By numerical continuation of fixed points with respect to energy, we find a transcritical bifurcation in our model system.
我们考虑了一个建立在倒立弹性摆上的经典人体跑步弹簧质量模型。基于我们之前关于大弹簧常数(或小迎角)渐近解的结果,我们构造了所考虑模型中解的解析近似。模型本身由两组微分方程组成——一组描述了与地面接触的转轮质心的运动(支撑阶段),第二组描述了不与地面接触阶段(飞行阶段)。通过适当地串联两个阶段的渐近解,我们能够将动力学简化为一维顶点到顶点的返回图。我们找到了这个映射具有唯一稳定不动点的充分条件。通过对不动点相对于能量的数值延拓,我们发现了模型系统中的跨临界分岔。
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引用次数: 0
On the instability, nonexistence and spatial behaviour of the one-dimensional response of a new class of elastic bodies 一类新弹性体一维响应的不稳定性、不存在性和空间行为
IF 1.2 4区 数学 Q3 Mathematics Pub Date : 2021-04-01 DOI: 10.1093/imamat/hxab014
R Quintanilla;K R Rajagopal
In this note we consider 1D problems within the context of a new class of elastic bodies. Under suitable conditions on the constitutive equations we prove instability and nonexistence of solutions similar to those in place for the linearized theory. The last section is devoted to describing the spatial behavior of the solutions.
在这篇笔记中,我们考虑一类新的弹性体背景下的一维问题。在适当的条件下,我们证明了本构方程解的不稳定性和不存在性与线性化理论解的不存在性相似。最后一节致力于描述解的空间行为。
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引用次数: 0
An initial-boundary value problem for the general three-component nonlinear Schrödinger equations on a finite interval 有限区间上一般三分量非线性Schrödinger方程的初边值问题
IF 1.2 4区 数学 Q3 Mathematics Pub Date : 2021-04-01 DOI: 10.1093/imamat/hxab007
Zhenya Yan
The general three-component nonlinear Schrödinger (gtc-NLS) equations are completely integrable and contain the self-focusing, defocusing and mixed cases, which are applied in many physical fields. In this paper, we would like to use the Fokas method to explore the initial-boundary value (IBV) problem for the gtc-NLS equations with a $4times 4$ matrix Lax pair on a finite interval based on the inverse scattering transform. The solutions of the gtc-NLS equations can be expressed using the solution of a $4times 4$ matrix Riemann–Hilbert (RH) problem constructed in the complex $k$-plane. The jump matrices of the RH problem can be explicitly found in terms of three spectral functions related to the initial data, and the Dirichlet–Neumann boundary data, respectively. The global relation between the distinct spectral functions is also proposed to derive two distinct but equivalent types of representations of the Dirichlet–Neumann boundary value problems. Particularly, the relevant formulae for the boundary value problems on the finite interval can generate ones on the half-line as the length of the interval closes to infinity. Finally, we also analyse the linearizable boundary conditions for the Gel'fand–Levitan–Marchenko representation. These results will be useful to further study the solution properties of the IBV problem of the gtc-NLS system by using the Deift–Zhou's nonlinear steepest descent method and some numerical methods.
一般的三分量非线性薛定谔(gtc-NLS)方程是完全可积的,包含自聚焦、散焦和混合情况,在许多物理领域都有应用。本文利用Fokas方法,基于逆散射变换,研究了有限区间上矩阵Lax对为$4×4$的gtc-NLS方程的初边值问题。gtc-NLS方程的解可以使用在复$k$-平面上构造的$4times 4$矩阵Riemann-Hilbert(RH)问题的解来表示。RH问题的跳跃矩阵可以分别根据与初始数据和Dirichlet–Neumann边界数据相关的三个谱函数明确地找到。还提出了不同谱函数之间的全局关系,以导出Dirichlet–Neumann边值问题的两种不同但等价的表示类型。特别地,当区间长度接近无穷大时,有限区间上的边值问题的相关公式可以在半线上生成。最后,我们还分析了Gel’fand–Levitan–Marchenko表示的可线性化边界条件。这些结果将有助于利用Deift–Zhou的非线性最速下降方法和一些数值方法进一步研究gtc-NLS系统IBV问题的解性质。
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引用次数: 11
Steady slip flow of Newtonian fluids through tangential polygonal microchannels 牛顿流体通过切向多边形微通道的稳态滑移流
IF 1.2 4区 数学 Q3 Mathematics Pub Date : 2021-04-01 DOI: 10.1093/imamat/hxab008
Grant Keady
The concern in this paper is the problem of finding—or, at least, approximating—functions, defined within and on the boundary of a tangential polygon, functions whose Laplacian is $-1$ and which satisfy a homogeneous Robin boundary condition on the boundary. The parameter in the Robin condition is denoted by $beta $. The integral of the solution over the interior, denoted by $Q$, is, in the context of flows in a microchannel, the volume flow rate. A variational estimate of the dependence of $Q$ on $beta $ and the polygon's geometry is studied. Classes of tangential polygons treated include regular polygons and triangles, especially isosceles: the variational estimate $R(beta)$ is a rational function which approximates $Q(beta)$ closely.
本文关注的是寻找——或者至少是近似——在切向多边形的边界内和边界上定义的函数的问题,这些函数的拉普拉斯算子为$1$,并且在边界上满足齐次Robin边界条件。Robin条件中的参数用$beta$表示。溶液在内部的积分,用$Q$表示,在微通道中流动的情况下,是体积流速。研究了$Q$对$beta$和多边形几何的依赖性的变分估计。处理的切向多边形包括正多边形和三角形,尤其是等腰多边形:变分估计$R(beta)$是一个接近$Q(beta)$的有理函数。
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引用次数: 5
Steady states and pattern formation of the density-suppressed motility model 密度抑制运动模型的稳态和模式形成
IF 1.2 4区 数学 Q3 Mathematics Pub Date : 2021-04-01 DOI: 10.1093/imamat/hxab006
Zhi-An Wang;Xin Xu
This paper considers the stationary problem of density-suppressed motility models proposed in Fu et al. (2012) and Liu et al. (2011) in one dimension with Neumman boundary conditions. The models consist of parabolic equations with cross-diffusion and degeneracy. We employ the global bifurcation theory and Helly compactness theorem to explore the conditions under which non-constant stationary (pattern) solutions exist and asymptotic profiles of solutions as some parameter value is small. When the cell growth is not considered, we are able to show the monotonicity of solutions and hence achieve a global bifurcation diagram by treating the chemical diffusion rate as a bifurcation parameter. Furthermore, we show that the solutions have boundary spikes as the chemical diffusion rate tends to zero and identify the conditions for the non-existence of non-constant solutions. When transformed to specific motility functions, our results indeed give sharp conditions on the existence of non-constant stationary solutions. While with the cell growth, the structure of global bifurcation diagram is much more complicated and in particular the solution loses the monotonicity property. By treating the growth rate as a bifurcation parameter, we identify a minimum range of growth rate in which non-constant stationary solutions are warranted, while a global bifurcation diagram can still be attained in a special situation. We use numerical simulations to test our analytical results and illustrate that patterns can be very intricate and stable stationary solutions may not exist when the parameter value is outside the minimal range identified in our paper.
本文考虑Fu et al.(2012)和Liu et al.(2011)提出的密度抑制运动模型在一维具有Neumman边界条件的平稳性问题。该模型由具有交叉扩散和简并的抛物型方程组成。利用全局分岔理论和Helly紧性定理,探讨了非常平稳(模式)解存在的条件和当某参数值较小时解的渐近轮廓。当不考虑细胞生长时,我们可以将化学扩散速率作为分岔参数来显示解的单调性,从而得到全局分岔图。进一步,我们证明了当化学扩散速率趋于零时,解具有边界尖峰,并确定了非常数解不存在的条件。当转化为具体的运动函数时,我们的结果确实给出了非常平稳解存在的尖锐条件。但随着细胞的增长,全局分岔图的结构变得复杂,特别是解的单调性逐渐丧失。通过将增长率作为分岔参数,我们确定了增长率的最小范围,在此范围内保证了非常平稳解,而在特殊情况下仍然可以得到全局分岔图。我们使用数值模拟来测试我们的分析结果,并说明模式可能非常复杂,当参数值超出我们论文中确定的最小范围时,稳定的固定解可能不存在。
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引用次数: 18
A method-of-lines formulation for a model of reactive settling in tanks with varying cross-sectional area 变截面储罐反应沉降模型的线性公式化方法
IF 1.2 4区 数学 Q3 Mathematics Pub Date : 2021-04-01 DOI: 10.1093/imamat/hxab012
Raimund Bürger;Julio Careaga;Stefan Diehl
Reactive settling denotes the process of sedimentation of small solid particles dispersed in a viscous fluid with simultaneous reactions between the components that constitute the solid and liquid phases. This process is of particular importance for the simulation and control of secondary settling tanks (SSTs) in water resource recovery facilities (WRRFs), formerly known as wastewater treatment plants. A spatially 1D model of reactive settling in an SST is formulated by combining a mechanistic model of sedimentation with compression with a model of biokinetic reactions. In addition, the cross-sectional area of the tank is allowed to vary as a function of height. The final model is a system of strongly degenerate parabolic, nonlinear partial differential equations that include discontinuous coefficients to describe the feed, underflow and overflow mechanisms, as well as singular source terms that model the feed mechanism. A finite difference scheme for the final model is developed by first deriving a method-of-lines formulation (discrete in space, continuous in time) and then passing to a fully discrete scheme by a time discretization. The advantage of this formulation is its compatibility with common practice in development of software for WRRFs. The main mathematical result is an invariant-region property, which implies that physically relevant numerical solutions are produced. Simulations of denitrification in SSTs in WRRFs illustrate the model and its discretization.
反应沉降是指分散在粘性流体中的小固体颗粒的沉降过程,构成固相和液相的组分之间同时发生反应。该过程对于水资源回收设施(WRRF)中的二次沉淀池(SST)的模拟和控制具有特别重要的意义,该设施以前被称为废水处理厂。通过将沉降和压缩的机理模型与生物动力学反应模型相结合,建立了SST中反应沉降的空间1D模型。此外,允许储罐的横截面积作为高度的函数而变化。最后的模型是一个强退化抛物型非线性偏微分方程组,该方程组包括描述进给、下溢和溢流机制的不连续系数,以及对进给机制建模的奇异源项。最终模型的有限差分格式是通过首先推导线公式化方法(空间上离散,时间上连续),然后通过时间离散化传递到完全离散格式来开发的。这种公式的优点是它与WRRF软件开发中的常见做法兼容。主要的数学结果是不变区域性质,这意味着产生了物理相关的数值解。WRRFs中SST中反硝化作用的模拟说明了该模型及其离散化。
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引用次数: 5
A dual self-monitored reconstruction scheme on the TV-regularized inverse conductivity problem TV正则化反导问题的对偶自监测重构方案
IF 1.2 4区 数学 Q3 Mathematics Pub Date : 2021-04-01 DOI: 10.1093/imamat/hxab011
Vanessa Markaki;Drosos Kourounis;Antonios Charalambopoulos
Recently in Charalambopoulos et al. (2020), we presented a methodology aiming at reconstructing bounded total variation ($TV$) conductivities via a technique simulating the so-called half-quadratic minimization approach, encountered in Aubert & Kornprobst (2002, Mathematical Problems in Image Processing. New York, NY: Springer). The method belongs to a duality framework, in which the auxiliary function $omega (x)$ was introduced, offering a tool for smoothing the members of the admissible set of conductivity profiles. The dual variable $omega (x)$, in that approach, after every external update, served in the formation of an intermediate optimization scheme, concerning exclusively the sought conductivity $alpha (x)$. In this work, we develop a novel investigation stemming from the previous approach, having though two different fundamental components. First, we do not detour herein the $BV$-assumption on the conductivity profile, which means that the functional under optimization contains the $TV$ of $alpha (x)$ itself. Secondly, the auxiliary dual variable $omega (x)$ and the conductivity $alpha (x)$ acquire an equivalent role and concurrently, a parallel pacing in the minimization process. A common characteristic between these two approaches is that the function $omega (x)$ is an indicator of the conductivity's ‘jump’ set. A fortiori, this crucial property has been ameliorated herein, since the reciprocal role of the elements of the pair $(alpha ,omega )$ offers a self-monitoring structure very efficient to the minimization descent.
最近,在Charalambopoulos等人(2020)中,我们提出了一种方法,旨在通过模拟Aubert&Kornprobst(2002,图像处理中的数学问题。纽约:施普林格)中遇到的所谓半二次最小化方法的技术来重建有界总变率($TV$)。该方法属于对偶框架,其中引入了辅助函数$omega(x)$,为平滑可容许电导率分布集的成员提供了一个工具。在该方法中,在每次外部更新之后,对偶变量$omega(x)$用于形成中间优化方案,仅涉及所寻求的电导率$alpha(x)$。在这项工作中,我们在之前的方法基础上发展了一项新的研究,尽管有两个不同的基本组成部分。首先,我们在这里没有绕过关于电导率分布的$BV$假设,这意味着优化下的函数包含$alpha(x)$本身的$TV$。其次,辅助对偶变量$omega(x)$和电导率$alpha(x)美元在最小化过程中获得了等效的作用,同时也获得了并行的起搏。这两种方法的共同特点是函数$omega(x)$是电导率“跳跃”集的指标。更重要的是,这一关键性质在本文中得到了改进,因为对$(alpha,omega)$的元素的相互作用提供了一种对最小化下降非常有效的自监测结构。
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引用次数: 1
Longitudinal thermocapillary slip about a dilute periodic mattress of protruding bubbles 纵向热毛细血管围绕一个稀的周期性的突出气泡垫滑动
IF 1.2 4区 数学 Q3 Mathematics Pub Date : 2021-04-01 DOI: 10.1093/imamat/hxab004
Ehud Yariv;Toby L Kirk
A common realization of superhydrophobic surfaces comprises of a periodic array of cylindrical bubbles which are trapped in a periodically grooved solid substrate. We consider the thermocapillary animation of liquid motion by a macroscopic temperature gradient which is longitudinally applied over such a bubble mattress. Assuming a linear variation of the interfacial tension with the temperature, at slope $sigma _T$, we seek the effective velocity slip attained by the liquid at large distances away from the mattress. We focus upon the dilute limit, where the groove width $2c$ is small compared with the array period $2l$. The requisite velocity slip in the applied-gradient direction, determined by a local analysis about a single bubble, is provided by the approximation $$begin{align*}& pi frac{Gsigma_T c^2}{mu l} I(alpha), end{align*}$$ wherein $G$ is the applied-gradient magnitude, $mu $ is the liquid viscosity and $I(alpha )$, a non-monotonic function of the protrusion angle $alpha $, is provided by the quadrature, $$begin{align*}& I(alpha) = frac{2}{sinalpha} int_0^inftyfrac{sinh salpha}{ cosh s(pi-alpha) sinh s pi} , textrm{d} s. end{align*}$$
超疏水表面的一种常见实现包括捕获在周期性槽状固体衬底中的圆柱形气泡的周期性阵列。我们考虑了液体运动的热毛细动画的宏观温度梯度,这是纵向施加在这种气泡床垫。假设界面张力随温度呈线性变化,斜率为$sigma _T$,我们寻求液体在远离床垫很远的地方获得的有效速度滑移。我们将重点放在稀释极限上,其中槽宽$2c$与阵列周期$2l$相比较小。在施加梯度方向上所需的速度滑移,由对单个气泡的局部分析确定,由近似$$begin{align*}& pi frac{Gsigma_T c^2}{mu l} I(alpha), end{align*}$$提供,其中$G$是施加梯度幅度,$mu $是液体粘度,$I(alpha )$是突出角$alpha $的非单调函数,由正交函数提供。 $$begin{align*}& I(alpha) = frac{2}{sinalpha} int_0^inftyfrac{sinh salpha}{ cosh s(pi-alpha) sinh s pi} , textrm{d} s. end{align*}$$
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引用次数: 5
期刊
IMA Journal of Applied Mathematics
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