Cover Caption: Scoliosis Rehabilitation with a Robotic Brace Powered by RL-based Impedance Control and Digital Twin: Adolescent Idiopathic Scoliosis (AIS) is commonly treated with traditional braces that rely solely on passive strap tensioning, lacking intelligent control strategies. This study proposes a reinforcement learning-based position-based impedance control (RLPIC) method for robotic braces to enable active human–robot interaction. To safely simulate and train the control system, a novel five-dimensional, three-layer digital twin (DT) model is developed, integrating physical modeling, digital modeling, bidirectional interaction, and optimization, enhanced by a neural network-based parameter estimator. Both numerical simulations and real-time experiments validate the DT and RLPIC framework, demonstrating improved tracking and interaction performance in AIS treatment.