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A Bio-inspired Low-frequency Vibration Isolator Based on Loofah Sponge Structure 基于丝瓜海绵结构的仿生低频隔振器
IF 5.8 3区 计算机科学 Q1 ENGINEERING, MULTIDISCIPLINARY Pub Date : 2026-02-11 DOI: 10.1007/s42235-026-00855-4
Weijun Tian, Xu Li, Xiaoli Wu, Haoran Huang, Linghua Kong

Inspired by the loofah sponge’s axially continuous porous core and peripheral hexagonal scaffold, we propose a compact bio-inspired low-frequency vibration isolator. An analytical static model reveals a Quasi-Zero-Stiffness (QZS) region produced by parallel coupling of an axial positive-stiffness spring and a nonlinear hexagonal link–spring unit. A Lagrangian dynamic model and ADAMS multibody simulations predict resonance and transmissibility and are validated by sinusoidal base-displacement tests. With a 5.775 kg payload, the prototype achieves effective isolation above ~ 5 Hz and ~ 25–30 dB attenuation at 20–22 Hz while retaining comparable load capacity to linear references of similar size. Compared with linear isolators, the designed bio-inspired low-frequency vibration isolator exhibits a lower isolation onset and a broader useful bandwidth under a compact footprint, offering tunable low-frequency isolation via geometric and stiffness parameters (α, k1, k3, l).

受丝瓜海绵轴向连续多孔核心和外围六边形支架的启发,我们提出了一种紧凑型仿生低频隔振器。解析静力模型揭示了轴向正刚度弹簧与非线性六边形连杆弹簧并联耦合产生的准零刚度区域。拉格朗日动力学模型和ADAMS多体模拟预测了共振和透射率,并通过正弦基位移试验进行了验证。该样机的有效载荷为5.775 kg,在20-22 Hz时实现了~ 5 Hz以上的有效隔离和~ 25-30 dB的衰减,同时保持了与类似尺寸的线性基准相当的负载能力。与线性隔振器相比,设计的仿生低频隔振器在紧凑的占地面积下具有更低的隔离起始时间和更宽的有用带宽,并通过几何和刚度参数(α, k1, k3, l)提供可调的低频隔离。
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引用次数: 0
Biomimetic Superhydrophobic Anti-icing Materials: Principles, Fabrication, Engineering Applications, and Challenges 仿生超疏水防冰材料:原理、制造、工程应用和挑战
IF 5.8 3区 计算机科学 Q1 ENGINEERING, MULTIDISCIPLINARY Pub Date : 2026-02-11 DOI: 10.1007/s42235-026-00839-4
Lina Hu, Jingxiao Yang, Yuhang Lei

Icing is a common natural phenomenon. However, it is widespread in various fields, including aerospace, power facilities, and others, where it can lead to equipment failure, reduced energy efficiency, and even severe safety accidents. In recent years, biomimetic superhydrophobic materials inspired by the surface of lotus leaves have shown significant potential for applications in anti-icing and de-icing due to their excellent hydrophobicity and low surface energy. This paper systematically introduces the anti-icing mechanisms of superhydrophobic coatings and provides a review of recent research progress on superhydrophobic materials in the field of anti-icing. Additionally, the application of these materials in three scenarios: wind turbine blades, power transmission lines, and aerospace equipment, was analysed to assess their prospects and feasibility in engineering projects. Finally, the current status of superhydrophobic anti-icing materials and the challenges they face are summarised, highlighting existing issues and offering perspectives for future research directions.

结冰是一种常见的自然现象。然而,它在各个领域广泛存在,包括航空航天,电力设施等,它可能导致设备故障,降低能源效率,甚至严重的安全事故。近年来,以荷叶表面为灵感的仿生超疏水材料由于其优异的疏水性和低表面能,在防冰和除冰方面显示出巨大的应用潜力。本文系统地介绍了超疏水涂层的防冰机理,综述了近年来超疏水材料在防冰领域的研究进展。此外,还分析了这些材料在三种场景中的应用:风力涡轮机叶片、输电线路和航空航天设备,以评估它们在工程项目中的前景和可行性。最后,总结了超疏水防冰材料的研究现状及面临的挑战,指出了存在的问题,并对未来的研究方向提出了展望。
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引用次数: 0
A Fast Integrated Gait, Footstep, and Motion Planning Framework for Wheeled-legged Robots 轮式腿机器人快速集成步态、脚步和运动规划框架
IF 5.8 3区 计算机科学 Q1 ENGINEERING, MULTIDISCIPLINARY Pub Date : 2026-02-10 DOI: 10.1007/s42235-025-00830-5
Renjie Li, Wei Dong, Jiarui Sun, Wenhao Li, Hui Dong, Yongzhuo Gao, Qijun Wu, Yi Long

Biological systems such as mountain goats and felines exhibit remarkable agility and adaptability when traversing complex terrains. Inspired by these capabilities, quadruped robots have been developed to mimic legged locomotion and improve mobility over uneven environments. To further enhance locomotion efficiency and terrain versatility, wheeled-legged robots integrate wheels and legs into a hybrid platform, enabling both high-speed traversal and robust ground contact in unstructured terrain. However, planning coordinated locomotion across diverse terrains remains challenging due to the nonlinear dynamics, complex terrain contact constraints, and multimodal locomotion capabilities. In this paper, we propose a real-time, integrated planning framework that jointly optimizes gait scheduling, footstep placement, and whole-body motion trajectories. Our method adopts a two-stage approach. First, a sampling-based planner generates candidate gait sequences and nominal footstep targets based on terrain features and kinematic feasibility. Second, a constrained trajectory optimizer reformulates the planning problem as a Quadratic Programming (QP) task to compute dynamically feasible base trajectories and corresponding ground reaction forces. This hybrid formulation balances planning efficiency and physical realism. The planned trajectories and contact forces are tracked using a hierarchical control architecture combining Model Predictive Control (MPC) and Whole-Body Control (WBC), enabling fast and stable execution on real hardware. Simulation and real-world experiments demonstrate that our approach enables adaptive gait transitions and improves terrain adaptability compared to traditional planners.

在穿越复杂地形时,山羊和猫科动物等生物系统表现出非凡的敏捷性和适应性。受这些能力的启发,四足机器人被开发出来模仿腿的运动,提高在不平坦环境中的机动性。为了进一步提高运动效率和地形通用性,轮腿机器人将车轮和腿集成到一个混合平台中,使其能够在非结构化地形中高速穿越和强大的地面接触。然而,由于非线性动力学、复杂的地形接触约束和多模式运动能力,规划跨不同地形的协调运动仍然具有挑战性。在本文中,我们提出了一个实时、集成的规划框架,共同优化步态调度、脚步放置和全身运动轨迹。我们的方法采用两阶段方法。首先,基于采样的规划器根据地形特征和运动可行性生成候选步态序列和标称步态目标。其次,约束轨迹优化器将规划问题重新表述为二次规划(QP)任务,以计算动态可行的基础轨迹和相应的地面反作用力。这种混合配方平衡了规划效率和物理现实性。使用结合模型预测控制(MPC)和全身控制(WBC)的分层控制体系结构跟踪规划的轨迹和接触力,从而在实际硬件上实现快速稳定的执行。仿真和现实世界的实验表明,与传统的规划器相比,我们的方法能够自适应步态转换,提高地形适应性。
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引用次数: 0
Design and Experiment of a Multi-driving Mode Bionic Hydraulic Knee Joint for Lower Limb Prosthesis 多驱动模式仿生液压下肢假体膝关节的设计与实验
IF 5.8 3区 计算机科学 Q1 ENGINEERING, MULTIDISCIPLINARY Pub Date : 2026-02-04 DOI: 10.1007/s42235-025-00831-4
Haisen Zeng, Xiangjuan Bai, Yiming Zhu, Zirong Luo

Achieving high drive efficiency remains a significant challenge in active knee prosthesis design. Inspired by human knee biomechanics, this study presents a novel biomimetic hydraulic drive system integrated with three human-like mechanisms: antagonistic muscle driving mechanism, dynamic simulation of muscle forces, and multi-stage collaborative energy supply. The system features a multi-stage hydraulic-rope hybrid transmission enabling adjustable damping and compliant motion control, coupled with a dual-cylinder configuration that boosts driving efficiency while delivering 29.7 Nm peak torque. A pump-valve hybrid control strategy is developed to dynamically adjust the flow and driving torque across gait phases, enhancing response speed and angular tracking accuracy. Through computational modeling, simulation, and prototype validation, we demonstrate that the proposed hydraulic drive system achieves efficient and responsive knee flexion and extension while meeting functional demands, reducing energy consumption by 20–50% compared to traditional pump-controlled systems. This study introduces a novel strategy for developing multimodal muscle-joint collaborative mechanisms, establishing a foundational framework for next-generation, high-performance bioinspired prostheses.

实现高驱动效率仍然是主动膝关节假体设计的重大挑战。受人类膝关节生物力学的启发,本研究提出了一种新型仿生液压驱动系统,该系统集成了三种类人机制:肌肉拮抗驱动机制、肌肉动力动态模拟机制和多级协同供能机制。该系统采用多级液压-绳索混合传动,可调节阻尼和柔性运动控制,再加上双缸配置,可提高驾驶效率,同时提供29.7 Nm的峰值扭矩。提出了一种泵-阀混合控制策略,在不同的步态阶段动态调节流量和驱动力矩,提高响应速度和角度跟踪精度。通过计算建模、仿真和原型验证,我们证明了所提出的液压驱动系统在满足功能需求的同时,实现了高效、灵敏的膝关节屈伸,与传统的泵控系统相比,能耗降低了20-50%。本研究介绍了一种开发多模态肌肉关节协作机制的新策略,为下一代高性能生物仿生假肢建立了基础框架。
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引用次数: 0
From Skin to Brain Activation: Decoding Frictional Pain in Amputees Versus Healthy Individuals 从皮肤到大脑激活:解码截肢者与健康人的摩擦性疼痛
IF 5.8 3区 计算机科学 Q1 ENGINEERING, MULTIDISCIPLINARY Pub Date : 2026-02-03 DOI: 10.1007/s42235-026-00842-9
Xingxing Fang, Wei Tang, Shousheng Zhang, Yanze Wu

The pain induced by the friction between residual limb and prosthetic socket is the significant issue that influence the comfort of prostheses. In this study, to reveal and compare the pain generation and processing mechanisms in amputees and healthy individuals, the skin friction, electroencephalogram, and functional Near-Infrared Spectroscopy tests were carried out. The Hodgkin-Huxley and Gate Control Theory models were used to reveal the neural transduction and transmission of frictional pain and connect the surface friction and brain activation of pain. The skin friction and subjective evaluation tests showed that compared with healthy skin, the residual limb skin exhibited poorer elastic properties, lower friction coefficients and higher frictional pain thresholds. The results showed that the hemodynamic response of amputees was insignificant and brain regions of amputees related with γ oscillations was smaller compared with healthy individuals. The changes of skin mechanical properties and neural reorganization may responsible for the difference in frictional pain response between amputees and healthy individuals. The results also showed that the increasing intensity of frictional pain can induce the increase of T-cell potential, resulting in the increasing HbO concentration and γ oscillations. This study provides a better understanding of pain generation mechanisms from skin surface to brain response using mathematical models. It also reveals the differences in frictional pain between amputees and healthy individuals.

残肢与义肢窝间摩擦引起的疼痛是影响义肢舒适性的重要问题。在本研究中,为了揭示和比较截肢者和健康者的疼痛产生和加工机制,我们进行了皮肤摩擦、脑电图和功能近红外光谱测试。采用霍奇金-赫胥黎和门控制理论模型揭示了摩擦性疼痛的神经传导和传递,并将疼痛的表面摩擦与大脑激活联系起来。皮肤摩擦和主观评价试验表明,与健康皮肤相比,残肢皮肤弹性性能差,摩擦系数低,摩擦痛阈值高。结果表明,截肢者的血流动力学反应不显著,与γ振荡相关的脑区比健康人小。皮肤力学特性和神经结构的变化可能是截肢者与健康人摩擦痛反应差异的主要原因。结果还表明,摩擦疼痛强度的增加可以诱导t细胞电位的增加,导致HbO浓度和γ振荡的增加。该研究利用数学模型更好地理解了从皮肤表面到大脑反应的疼痛产生机制。它还揭示了截肢者和健康人在摩擦性疼痛方面的差异。
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引用次数: 0
Analysis of a Mirror-based Assist-as-needed Strategy via Task-performance-based Adaptive Impedance Control 基于任务性能的自适应阻抗控制的镜像辅助策略分析
IF 5.8 3区 计算机科学 Q1 ENGINEERING, MULTIDISCIPLINARY Pub Date : 2026-01-29 DOI: 10.1007/s42235-026-00847-4
Qing Sun, Qingfeng Li, Xiaolong Yang, Shuai Guo, Jianwei Niu

Mirror-assisted strategies are commonly used in the rehabilitation training of patients with hemiparesis in the upper limbs following a stroke. Traditional robotic mirror assistance focuses on achieving high-precision mirror trajectory tracking, often neglecting the issue of active movement in the affected side. This paper proposes a task performance-based adaptive impedance control, where the robot assists the affected side in an assist-as-needed manner, thereby encouraging the patient to perform active movements. To account for inter-individual variability, a method for assessing the affected side’s motor performance, based on the healthy side’s movement level, is introduced. Adaptive impedance control is then constructed based on the motor performance of the affected side, enabling the robot to provide adaptive assistance force. Eight healthy participants were recruited for experimental testing. Experimental results show that when the robot provides mirror-based assist-as-needed to the affected side, the robot’s stiffness coefficient and assistance force are positively correlated with the motor assessment coefficient of the affected side, thereby verifying the feasibility of the proposed strategy. This study offers a robotic-assisted rehabilitation strategy for stroke patients that balances active participation and individual adaptability, with the potential to enhance rehabilitation outcomes and enable precise rehabilitation interventions.

镜像辅助策略通常用于中风后上肢偏瘫患者的康复训练。传统的机器人反射镜辅助侧重于实现高精度的反射镜轨迹跟踪,往往忽略了受影响侧的主动运动问题。本文提出了一种基于任务性能的自适应阻抗控制,其中机器人以需要的方式辅助患处,从而鼓励患者进行主动运动。为了考虑个体间的差异,介绍了一种基于健康侧运动水平来评估患病侧运动表现的方法。然后根据受影响侧的电机性能构建自适应阻抗控制,使机器人能够提供自适应辅助力。招募了8名健康参与者进行实验测试。实验结果表明,当机器人对受影响侧提供基于镜像的按需辅助时,机器人的刚度系数和辅助力与受影响侧的运动评估系数呈正相关,从而验证了所提策略的可行性。这项研究为中风患者提供了一种机器人辅助康复策略,平衡了积极参与和个体适应性,具有提高康复效果和实现精确康复干预的潜力。
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引用次数: 0
Enhancing Lower Limb Exoskeleton Control in Rehabilitation Through Traditional Machine Learning Techniques: A Review 通过传统机器学习技术增强下肢外骨骼康复控制:综述
IF 5.8 3区 计算机科学 Q1 ENGINEERING, MULTIDISCIPLINARY Pub Date : 2026-01-28 DOI: 10.1007/s42235-025-00836-z
Javlonbek Rakhmatillaev, Nodirbek Kimsanboev, Umidjon Takabaev, Vytautas Bučinskas, Zafar Juraev

This review explores the potential of incorporating Machine Learning (ML) and Artificial Intelligence (AI) into the control systems of Lower Limb Rehabilitation Exoskeletons (LLREs), with a focus on its capacity to advance the field of rehabilitation robotics. It examines applications in optimizing personalized control supporting trajectory adaptation and key metrics in rehabilitation and discusses the challenges and limitations of traditional ML control methods supervised, unsupervised, and Reinforcement Learning (RL) in LLRE control. We analyze the specific aspects of traditional ML techniques in controlling the rehabilitation exoskeleton. Finally, the results of scientific solutions and developments in the implementation of gait parameters for personalized control that support the trajectory adaptation of the rehabilitation process are studied. Clinical applications and case studies directly describe the shortcomings and advantages of the field.

本文探讨了将机器学习(ML)和人工智能(AI)纳入下肢康复外骨骼(LLREs)控制系统的潜力,重点是其推进康复机器人领域的能力。它研究了在优化个性化控制方面的应用,支持康复中的轨迹适应和关键指标,并讨论了传统ML控制方法在LLRE控制中的挑战和局限性,包括监督、无监督和强化学习(RL)。我们分析了传统机器学习技术在康复外骨骼控制中的具体方面。最后,研究了支持康复过程轨迹适应的个性化控制步态参数的科学解决方案和实施进展的结果。临床应用和案例研究直接描述了该领域的缺点和优点。
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引用次数: 0
Fatigue Detection with Multimodal Physiological Signals via Uncertainty-Aware Deep Transfer Learning 基于不确定性感知深度迁移学习的多模态生理信号疲劳检测
IF 5.8 3区 计算机科学 Q1 ENGINEERING, MULTIDISCIPLINARY Pub Date : 2026-01-13 DOI: 10.1007/s42235-025-00827-0
Kourosh Kakhi, Hamzeh Asgharnezhad, Abbas Khosravi, Roohallah Alizadehsani, U. Rajendra Acharya

Accurate detection of driver fatigue is essential for improving road safety. This study investigates the effectiveness of using multimodal physiological signals for fatigue detection while incorporating uncertainty quantification to enhance the reliability of predictions. Physiological signals, including Electrocardiogram (ECG), Galvanic Skin Response (GSR), and Electroencephalogram (EEG), were transformed into image representations and analyzed using pretrained deep neural networks. The extracted features were classified through a feedforward neural network, and prediction reliability was assessed using uncertainty quantification techniques such as Monte Carlo Dropout (MCD), model ensembles, and combined approaches. Evaluation metrics included standard measures (sensitivity, specificity, precision, and accuracy) along with uncertainty-aware metrics such as uncertainty sensitivity and uncertainty precision. Across all evaluations, ECG-based models consistently demonstrated strong performance. The findings indicate that combining multimodal physiological signals, Transfer Learning (TL), and uncertainty quantification can significantly improve both the accuracy and trustworthiness of fatigue detection systems. This approach supports the development of more reliable driver assistance technologies aimed at preventing fatigue-related accidents.

准确检测驾驶员疲劳对提高道路安全至关重要。本研究探讨了使用多模态生理信号进行疲劳检测的有效性,同时结合不确定性量化来提高预测的可靠性。将包括心电图(ECG)、皮肤电反应(GSR)和脑电图(EEG)在内的生理信号转换为图像表示,并使用预训练的深度神经网络进行分析。通过前馈神经网络对提取的特征进行分类,并使用蒙特卡罗Dropout (MCD)、模型集成和综合方法等不确定性量化技术评估预测可靠性。评估度量包括标准度量(灵敏度、特异性、精密度和准确性)以及不确定性感知度量(如不确定性灵敏度和不确定性精度)。在所有的评估中,基于脑电图的模型始终表现出强大的性能。研究结果表明,将多模态生理信号、迁移学习(TL)和不确定性量化相结合可以显著提高疲劳检测系统的准确性和可信度。这种方法支持开发更可靠的驾驶员辅助技术,旨在防止疲劳相关的事故。
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引用次数: 0
The Modeling and Nonlinear Dynamic Analysis of Volume-Controlled Hydraulic Artificial Muscles 容积控制液压人工肌肉的建模与非线性动力学分析
IF 5.8 3区 计算机科学 Q1 ENGINEERING, MULTIDISCIPLINARY Pub Date : 2026-01-13 DOI: 10.1007/s42235-025-00835-0
Jialin Dou, Jun Li, Yanbo Wang, Hongzhou Jiang

Hydraulic artificial muscles offer higher stiffness and faster response. Unlike pneumatic artificial muscles, which rely on pressure control, hydraulic artificial muscles are more suitable for volume control. This study focuses on the modeling and nonlinear dynamic analysis of volume-controlled McKibben hydraulic artificial muscles. To address the limitations of existing models, a hierarchical semi-empirical modeling method is adopted to construct a static model with constant volume, which integrates a geometric model and a static force model. This model supports not only pressure control, but also volume control, and considers the end effects, the effective bulk modulus, and the nonlinear dependence of artificial muscles on Young’s modulus. Furthermore, a dynamic model encompassing four state parameters is established by combining the static model with fluid continuity equations, enabling the characterization of dynamic responses under volume control. Experimental methods were employed to determine the parameters in the formulas, significantly improving the accuracy of calculating the required injected volume for the given contraction ratio and load force. Nonlinear dynamics analysis reveals that HAM exhibit significant nonlinear damping, and the initial volume of connecting pipes significantly affects static pressure and working performance. Experimental validation shows that the static model achieves a maximum relative error of 2.05% in contraction ratio, while the dynamic model accurately captures the second-order oscillatory characteristics of force and pressure responses. This research provides a comprehensive modeling framework for volume-controlled HAM and deepens the understanding of their nonlinear dynamic behavior, facilitating engineering applications in robotics and rehabilitation devices.

液压人造肌肉提供更高的刚度和更快的响应。与气动人工肌肉依靠压力控制不同,液压人工肌肉更适合于体积控制。本文主要研究了体积控制McKibben液压人工肌肉的建模和非线性动力学分析。针对现有模型的局限性,采用分层半经验建模方法构建几何模型和静力模型相结合的等体积静态模型。该模型不仅支持压力控制,还支持体积控制,并考虑了末端效应、有效体积模量以及人工肌肉对杨氏模量的非线性依赖关系。此外,将静态模型与流体连续性方程相结合,建立了包含4个状态参数的动态模型,实现了体积控制下的动态响应表征。采用实验方法确定公式中的参数,显著提高了给定收缩比和载荷力下所需注入体积的计算精度。非线性动力学分析表明,连接管具有显著的非线性阻尼,连接管初始体积对管道静压和工作性能有显著影响。实验验证表明,静态模型在收缩比上的最大相对误差为2.05%,而动态模型准确地捕捉了力和压力响应的二阶振荡特性。本研究为体控人工智能提供了一个全面的建模框架,加深了对其非线性动力学行为的理解,有助于在机器人和康复设备方面的工程应用。
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引用次数: 0
Bionic Design of Copper-doped Mesoporous Silica with Enhanced Hydrogel Mechanical Properties and its Promising Application in Bone-defect Regeneration 增强水凝胶力学性能的铜掺杂介孔二氧化硅仿生设计及其在骨缺损再生中的应用前景
IF 5.8 3区 计算机科学 Q1 ENGINEERING, MULTIDISCIPLINARY Pub Date : 2026-01-13 DOI: 10.1007/s42235-025-00821-6
Han Yang, Ya Fang, Jiaming Cui, Xueheng Sun, Tianchang Wang, Liang Feng, Hao Yang, Changru Zhang, Bide Xu, Xiaojun Zhou, Jinwu Wang, Xudong Wang

Treating bone defects complicated by bacterial infections remains a significant clinical challenge. Drawing inspiration from the human body’s bone repair mechanisms, the use of biomimetic methods to design tissue engineering scaffolds is of great significance for bone repair. This study synthesized copper (Cu)-doped mesoporous silica nanoparticles (Cu@MSN) modified with hydroxyethyl methacrylate to obtain methacrylated Cu@MSN (Cu@MSNMA). Furtheremore, biomimetic nanocomposite hydrogels were prepared by adding Cu@MSNMA to a GelMA/gelatin solution. This hydrogel achieves multi-modal bone tissue biomimicry: (i) GelMA/gelatin mimics the matrix components in bone ECM, ensuring biocompatibility while promoting cellular behavior (such as adhesion, proliferation, and differentiation); (ii) GelMA/gelatin and the crosslinking sites introduced by Cu@MSNMA form a stable porous network structure, achieving structural and mechanical biomimicry to provide necessary support for bone defects; (iii) The elemental biomimicry of Si and Cu in Cu@MSNMA achieves efficient osteogenic induction. The effect of different proportions of Cu@MSNMA on the physical properties of the composite hydrogels was investigated to determine the optimal proportion. The results indicated that the mechanical properties of hydrogel were enhanced with the increasing Cu@MSNMA mass ratio. Notably, 5% NPs/GelMA/gelatin hydrogel exhibited excellent mechanical property compared to the GelMA/gelatin hydrogel. In vitro and vivo cellular experiments demonstrated a significant enhancement in antibacterial and osteogenic induction with Cu@MSNMA addition. In conclusion, the proposed nanocomposite hydrogel with biomimetic components and ion-regulating properties can serve as a multifunctional scaffold, offering antimicrobial properties for infected bone regeneration, and guide for future research in bone regeneration and three-dimensional printing.

治疗合并细菌感染的骨缺损仍然是一个重大的临床挑战。从人体骨修复机制中汲取灵感,利用仿生方法设计组织工程支架对骨修复具有重要意义。本研究合成了掺杂铜(Cu)的介孔二氧化硅纳米颗粒(Cu@MSN),并用甲基丙烯酸羟乙酯修饰得到甲基丙烯酸化Cu@MSN (Cu@MSNMA)。在凝胶/明胶溶液中加入Cu@MSNMA制备仿生纳米复合水凝胶。这种水凝胶实现了多模态骨组织仿生学:(i) GelMA/明胶模拟骨ECM中的基质成分,在促进细胞行为(如粘附、增殖和分化)的同时确保生物相容性;(ii) GelMA/明胶与Cu@MSNMA引入的交联位点形成稳定的多孔网络结构,实现结构和机械仿生学,为骨缺损提供必要的支撑;(iii) Cu@MSNMA中Si和Cu元素的仿生学实现了高效的成骨诱导。研究了Cu@MSNMA不同配比对复合水凝胶物理性能的影响,确定了最佳配比。结果表明:随着Cu@MSNMA质量比的增大,水凝胶的力学性能得到增强。值得注意的是,与GelMA/明胶水凝胶相比,5% NPs/GelMA/明胶水凝胶表现出优异的力学性能。体外和体内细胞实验表明,添加Cu@MSNMA可显著增强抗菌和成骨诱导作用。综上所述,具有仿生成分和离子调节特性的纳米复合水凝胶可作为一种多功能支架,为感染骨再生提供抗菌性能,并为未来骨再生和三维打印的研究提供指导。
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引用次数: 0
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Journal of Bionic Engineering
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