Journal of Chemical Sciences最新文献

A new azo-Schiff base derivative compounds have been synthesized and characterized by FTIR, ¹HNMR, ¹³CNMR and elemental analysis techniques. The azo-Schiff base compounds were evaluated for their cytotoxicity against human epithelial breast adenocarcinoma (MCF7) and human epithelial cervix adenocarcinoma (HeLa) cell lines using the MTT assay. Compound 4a exhibited potent in vitro antiproliferative activity with IC₅₀ 120.0 and 140.8 μM against HeLa and MCF7 cell lines, respectively. As a result of the cell migration study, compound 4a achieved 38%, recovery in HeLa cells at 48 hours and 59% in MCF7 cells at 48 hours. Compound 4b achieved 12% recovery in HeLa cells at 48 hours and 49% in MCF7 cells at 48 hours. Apoptosis analysis studies show that the synthesized compounds (4a-b) can induce apoptosis in the HeLa and MCF7 cells.

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The IC₅₀ dose of compound 4a was found to be 120.0 µL in the HeLa cell line and 140.8 µL in the MCF7 cell line. Furthermore, it has also been observed that compounds 4a and 4b can increase the apoptotic effect in both cell lines significantly compared with control group.

Pyridine fused heterocycles are vital in material sciences, medicinal chemistry, and organic synthesis due to their distinct structural feature. These compounds, consisting of two or more heterocyclic rings, share one or more hetero atoms. They exhibit enhanced stability, varied electronic properties, and improved biological activity compared to their non-fused counterparts. The fusion of heterocyclic rings often leads to a rigid, planar structure that can interact more efficiently with biological targets, making them valued in advancing pharmaceuticals, particularly for intricate diseases. Additionally, fused heterocycles are important in designing functional materials, such as organic semiconductors and catalysts, due to their ability to impart desired electronic and optical properties. Their broad pertinence and the ability to fine-tune their characteristics through synthetic modifications continue to drive advancements in basic and applied chemistry. The fused heterocycles discussed in this review are furo-pyridine, pyrrolo-pyridine, and other assorted fused heterocycles. Their biological importance and synthetic procedures have been discussed.

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The fused heterocycles discussed are furo-pyridine, pyrrolo-pyridine, and other assorted fused heterocycles. The biological importance and synthetic procedures of these fused heterocycles have been discussed. Pyridine fused heterocycles are vital in material sciences, medicinal chemistry, and organic synthesis due to their distinct structural feature.

Phase-pure CeO₂ was synthesized by the solution combustion method, which crystallized in its cubic fluorite structure. The synthesized catalyst was characterized by SEM, EDX analysis, powder XRD, H₂-TPR and FTIR to confirm its structure. This precious metal-free catalyst shows excellent activity towards the ligand-free Suzuki–Miyaura coupling reaction in aqueous media. Various biaryls, such as symmetrical, asymmetrical and heterocyclic moieties were obtained from corresponding aryl halides and arylboronic acid with good yields. The ceria can be coated on cordierite monolith, which acts as a catalyst cartridge, employed with ease in recycling experiments. An attempt for scale-up reaction is also carried out with a good yield.

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The phase pure CeO₂ was synthesized by the solution combustion method which crystallized in its cubic fluorite structure. This precious metal-free catalyst shows excellent activity towards the ligand-free Suzuki-Miyaura coupling reaction in aqueous media. Recycling and scale-up reactions are carried out by employing catalyst coated cordierite monolith with ease.

The orange flavour, n-octyl acetate, was synthesized in the presence of ultrasound (US) over an H₅PW₁₀V₂O₄₀ /FAC catalyst. The effect of parameters such as temperature (A), alcohol to acid ratio (B), duty cycle (C) and ultrasound power (D) on the conversion was optimised using response surface methodology. Various experiments were designed as per the central composite design method using the design of expert software. The relation between operating variables and conversion was established by a quadratic mathematical model equation. The relation of independent variables and their effect on conversion was explained by executing the statistical analysis and analysis of variance. The optimum solution of the maximum conversion of 78.2% in 180 minutes was obtained in the presence of US horn at parameters viz temperature (373 K), mole ratio (n-octyl alcohol to acetic acid) (2), duty cycle (80%) and ultrasound power (100 W). The intensification by US horn was compared to conventional processes.

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The n-octyl acetate was synthesized over an H₅PW₁₀V₂O₄₀/FAC catalyst in the presence of ultrasound irradiation. It has many applications in cosmetics, hair products, and skin locations. The synthesis of n-octyl acetate in the ultrasound process was compared with the conventional synthesis. There was a considerable reduction in reaction time in ultrasound-assisted synthesis.

Meso tetra-anthracenyl porphyrin (TAP) was synthesized by pyrrole and 9-anthraldehyde (9-anthracene carboxaldehyde) in different yields. In the current synthetic methods, meso tetra-anthracenyl porphyrin (TAP) was synthesized with 8% yields. The first method involved iodine (I₂) as Lewis acid, and in the second method, hydroxyl ammonium chloride (NH₂OH·HCl) was used as a Lewis acid and proceeded in the presence of nitrobenzene. The formation of the product was confirmed with the help of various characterizations i.e., UV-visible, ¹H NMR, ¹³C NMR and mass spectrometry.

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The 5,10,15,20-tetra(9-anthracenyl) porphyrin (TAP) was synthesized by two newer methods in high yield (8% yield). The first method involved iodine (I₂) as a catalyst which proceeded at room temperature, and in the second method, hydroxyl ammonium chloride (NH₂OH·HCl) was used as a Lewis acid and proceeded in the presence of nitrobenzene. The various UV-vis studies of TAP were studies with different salts and acids.

A rapid and environmentally friendly method was developed for synthesizing 1,5-benzodiazepine derivatives, utilizing catalytic quantities of thiamine hydrochloride in an aqueous media. The desired compounds were acquired with notable yields by amalgamating variously substituted aryl aldehydes with dimedone and o-phenylene diamine using thiamine hydrochloride as a catalyst. This approach presents several benefits, including swift reaction kinetics, utilization of eco-friendly solvents, straightforward workup procedures and a facile purification process, ensuring energy conservation and extensive compatibility with diverse substrates.

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Synopsis. A green, rapid, and efficient method for synthesizing 1,5-benzodiazepine derivatives was developed using thiamine hydrochloride as a catalyst in water. This environmentally benign approach achieved excellent yields, compatibility with diverse substrates, and minimal reaction times, highlighting its potential as a sustainable alternative in heterocyclic compound synthesis.

In this work, sulfonic acid group modified ZSM-5 (SFZ-x, x presents the weight percentage of mercaptopropyltrimethoxysilane during preparation) has been prepared by introducing sulfydryl on ZSM-5 and then oxidizing them into the sulfonic acid group. The obtained samples were characterized by XRD, N₂ adsorption/desorption, FTIR, and SEM and studied the catalytic performance in the hydration of cyclohexene to produce cyclohexanol. The characterization results showed that with the introduction of -SO₃H, the crystallinity of SFZ-15 decreased slightly, and the Brønsted acid sites obviously increased, while the pore structure was almost unchanged inside the ZSM-5 zeolites. Therefore, SFZ-15 exhibits better catalytic performance in the hydration of cyclohexene to produce cyclohexanol compared to commercial ZSM-5. Furthermore, this SFZ-15 catalyst kept the conversion of cyclohexene over 12% and the selectivity of cyclohexanol over 99% even after five runs, demonstrating the benefit of –SO₃H functionalization on the activity improvement of traditional ZSM-5 catalyst.

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The sulfonic acid group modified ZSM-5 zeolite has been prepared by introducing sulfydryl on ZSM-5 and then oxidizing them into the sulfonic acid group. The prepared catalyst exhibits excellent catalytic performance in the hydration of cyclohexene to produce cyclohexanol.

Topological descriptors are quantitative parameters that correlate the attributes of molecular structures, providing insights into their chemical properties and behavior. With the increasing significance of dendrimers in drug design, driven by advancements in technology, our study focuses on the topological analysis of non-conjugated ethylene oxide cored dendrimer decorated with tetraphenylethylene. We derive key degree-based descriptors, including degree, neighborhood degree, and reverse degree, using the novel M-polynomial approach. This innovative method not only facilitates the calculation of these descriptors but also has the potential to generate additional descriptors. Our results demonstrate the applicability of these descriptors in Quantitative Structure-Property Relationship (QSPR) and Quantitative Structure-Activity Relationship (QSAR) models, predicting properties across different generations of the dendrimer. Furthermore, a graphical comparison is provided to enhance the understanding and analysis of the derived descriptors. This work represents a significant step forward in the mathematical modeling of dendritic structures, offering new tools for researchers in the field of chemical graph theory and molecular chemistry.

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This study presents a computational framework for predicting molecular properties without experimental research. Molecular descriptors, including degree based and entropy measures, are utilized in QSPR analysis. Statistical tools and regression models facilitate property prediction, offering valuable insights into molecular structures and their characteristics through topological descriptors.

We developed a mild protocol for the formal insertion of diazo compounds into the C–H bond of electron deficient 1,3-dicarbonyl compounds. The Lewis acid-catalyzed reaction proceeds through protonation of the diazo compound followed by nucleophilic substitution of diazo-N₂ with dicarbonyl substrate. The reaction is notable for its mild conditions, wide substrate scope and high yields of the products.

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A facile and efficient synthesis of polysubstituted pyridin-2(1H)-ones has been developed via a formal [4+2] annulation of readily available α-functionalized β-aminoacrylamides and malononitrile in the presence of potassium carbonate (K₂CO₃) in dimethylsulfoxide (DMSO).

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