Organoids-on-a-chip is a newly emerging and frontier field with a marriage of organoids and microfluidic organ-on-a-chip technology. The synergistic engineering strategies can be adopted to build organ model systems in high fidelity, and to hold great potential in studies of organ development, disease modeling, drug discovery and regenerative medicine. In this review, we introduce the origin, key features and recent progress of organoids-on-chips. The future opportunities and major challenges to advance organoids-on-a-chip systems are also discussed.
{"title":"Organoids-on-a-chip","authors":"Yaqing Wang, Tingting Tao, J. Qin","doi":"10.1360/ssv-2022-0027","DOIUrl":"https://doi.org/10.1360/ssv-2022-0027","url":null,"abstract":"Organoids-on-a-chip is a newly emerging and frontier field with a marriage of organoids and microfluidic organ-on-a-chip technology. The synergistic engineering strategies can be adopted to build organ model systems in high fidelity, and to hold great potential in studies of organ development, disease modeling, drug discovery and regenerative medicine. In this review, we introduce the origin, key features and recent progress of organoids-on-chips. The future opportunities and major challenges to advance organoids-on-a-chip systems are also discussed.","PeriodicalId":61900,"journal":{"name":"中国科学(生命科学)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41687024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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