{"title":"Follicular Dendritic Cell Sarcoma: A Rare Case Study of Meta-Synchronous Double Primary Cancers Follicular Dendritic Sarcoma and Invasive Breast Cancer","authors":"E. Barsoum, Sara El Sherif, M. Ashour, M. Barsoum","doi":"10.4236/jct.2022.136029","DOIUrl":"https://doi.org/10.4236/jct.2022.136029","url":null,"abstract":"","PeriodicalId":66197,"journal":{"name":"癌症治疗(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70994081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sara Anane, A. Ghanam, M. Azizi, A. Bennani, H. Benhaddou, I. Kamaoui, N. Benajiba
{"title":"Pleural Effusion Revealing Bone Ewing Sarcoma: About Three Cases","authors":"Sara Anane, A. Ghanam, M. Azizi, A. Bennani, H. Benhaddou, I. Kamaoui, N. Benajiba","doi":"10.4236/jct.2022.135024","DOIUrl":"https://doi.org/10.4236/jct.2022.135024","url":null,"abstract":"","PeriodicalId":66197,"journal":{"name":"癌症治疗(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70994085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.4236/jct.2022.1312059
Nicola Sarandria
{"title":"A Literature Review in Immuno-Oncology: Pathophysiological and Clinical Features of Colorectal Cancer and the Role of the Doctor-Patient Interaction","authors":"Nicola Sarandria","doi":"10.4236/jct.2022.1312059","DOIUrl":"https://doi.org/10.4236/jct.2022.1312059","url":null,"abstract":"","PeriodicalId":66197,"journal":{"name":"癌症治疗(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70993274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Doumbia, M. Amadou, B. Amadou, S. Zakari, Coulibaly Bourama, Diarra Bourama, T. Adégné
{"title":"Primitive Brelast Lymphoma about a Case: Literature Review","authors":"A. Doumbia, M. Amadou, B. Amadou, S. Zakari, Coulibaly Bourama, Diarra Bourama, T. Adégné","doi":"10.4236/jct.2022.133014","DOIUrl":"https://doi.org/10.4236/jct.2022.133014","url":null,"abstract":"","PeriodicalId":66197,"journal":{"name":"癌症治疗(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70993568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Benali, T. Kebdani, K. Hassouni, S. Majjaoui, H. Kacemi, N. Benjaafar
Background: Sarcomatoid carcinoma is a rare biphasic malignancy with an epithelial and mesenchymal component. Given its histological particularity, the diagnosis of this tumor still represents a challenge for pathologists and surgeons. Sarcomatoid carcinoma of the mandible is a very rare and aggressive entity. To date, only sporadic cases have been reported in the literature. Aim: To report a rare case of aggressive mandibular sarcomatoid carcinoma treated with radical surgery and adjuvant chemoradiation, and discuss the re-lated literature. Case Report: We introduce a rare case of mandibular sarcomatoid carcinoma occurring in a 34-year-old woman. Treatment consisted of radical surgery and re-excision for positive margins, adjuvant radiation therapy (66 Gy in 33 fractions in simultaneous integrated boost delivered using Volumetric Modulated Arc Therapy) and Cisplatin-based concurrent chemotherapy. The tumor displayed aggressive behavior and high metastatic po-tential, causing tumour recurrence and extensive lung metastasis. Conclu-sion: Sarcomatoid carcinoma of the mandible is an extremely rare malignant entity, with a high tendency for local recurrence, distant metastasis. Treatment involves radical surgery and adjuvant chemoradiation, although the outcome and prognosis might be poor.
{"title":"Sarcomatoid Carcinoma of the Mandible: A Case Report and Literature Review","authors":"K. Benali, T. Kebdani, K. Hassouni, S. Majjaoui, H. Kacemi, N. Benjaafar","doi":"10.4236/jct.2022.136028","DOIUrl":"https://doi.org/10.4236/jct.2022.136028","url":null,"abstract":"Background: Sarcomatoid carcinoma is a rare biphasic malignancy with an epithelial and mesenchymal component. Given its histological particularity, the diagnosis of this tumor still represents a challenge for pathologists and surgeons. Sarcomatoid carcinoma of the mandible is a very rare and aggressive entity. To date, only sporadic cases have been reported in the literature. Aim: To report a rare case of aggressive mandibular sarcomatoid carcinoma treated with radical surgery and adjuvant chemoradiation, and discuss the re-lated literature. Case Report: We introduce a rare case of mandibular sarcomatoid carcinoma occurring in a 34-year-old woman. Treatment consisted of radical surgery and re-excision for positive margins, adjuvant radiation therapy (66 Gy in 33 fractions in simultaneous integrated boost delivered using Volumetric Modulated Arc Therapy) and Cisplatin-based concurrent chemotherapy. The tumor displayed aggressive behavior and high metastatic po-tential, causing tumour recurrence and extensive lung metastasis. Conclu-sion: Sarcomatoid carcinoma of the mandible is an extremely rare malignant entity, with a high tendency for local recurrence, distant metastasis. Treatment involves radical surgery and adjuvant chemoradiation, although the outcome and prognosis might be poor.","PeriodicalId":66197,"journal":{"name":"癌症治疗(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70994031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manju Domnick, Martin Domnick, I. Ernst, F. Müller, Viktor Rempel, N. Bitterlich, H. Sahinbas, S. Könemann, S. Philippou
{"title":"Observations from the Working Group Peritoneal Carcinosis","authors":"Manju Domnick, Martin Domnick, I. Ernst, F. Müller, Viktor Rempel, N. Bitterlich, H. Sahinbas, S. Könemann, S. Philippou","doi":"10.4236/jct.2022.138045","DOIUrl":"https://doi.org/10.4236/jct.2022.138045","url":null,"abstract":"","PeriodicalId":66197,"journal":{"name":"癌症治疗(英文)","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70994714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuru Chen, Jing Feng, Juan Liu, Baochuan Pang, Defa Cao, Cheng Li
Lung cancer is one of the greatest threats to human health. It is a very effective way to detect lung cancer by pathological pictures of lung cancer cells. Therefore, improving the accuracy and stability of diagnosis is very impor-tant. In this study, we develop an automatic detection scheme for lung cancer cells based on convolutional neural networks and Swin Transformer. Microscopic images of patients’ lung cells are first segmented using a Mask R-CNN-based network, resulting in a separate image for each cell. Part of the background information is preserved by Gaussian blurring of surrounding cells, while the target cells are highlighted. The classification model based on Swin Transformer not only reduces the computation but also achieves better results than the classical CNN model, ResNet50. The final results show that the accuracy of the method proposed in this paper reaches 96.16%. Therefore, this method is helpful for the detection and classification of lung cancer cells.
肺癌是人类健康的最大威胁之一。通过肺癌细胞的病理图像检测肺癌是一种非常有效的方法。因此，提高诊断的准确性和稳定性非常重要。在这项研究中，我们开发了一种基于卷积神经网络和Swin Transformer的肺癌细胞自动检测方案。首先使用基于Mask r - cnn的网络对患者肺细胞的显微图像进行分割，从而为每个细胞生成单独的图像。对周围细胞进行高斯模糊处理，保留部分背景信息，突出显示目标细胞。基于Swin Transformer的分类模型不仅减少了计算量，而且取得了比经典CNN模型ResNet50更好的分类效果。最终结果表明，本文方法的准确率达到96.16%。因此，该方法有助于肺癌细胞的检测和分类。
{"title":"Detection and Classification of Lung Cancer Cells Using Swin Transformer","authors":"Yuru Chen, Jing Feng, Juan Liu, Baochuan Pang, Defa Cao, Cheng Li","doi":"10.4236/jct.2022.137041","DOIUrl":"https://doi.org/10.4236/jct.2022.137041","url":null,"abstract":"Lung cancer is one of the greatest threats to human health. It is a very effective way to detect lung cancer by pathological pictures of lung cancer cells. Therefore, improving the accuracy and stability of diagnosis is very impor-tant. In this study, we develop an automatic detection scheme for lung cancer cells based on convolutional neural networks and Swin Transformer. Microscopic images of patients’ lung cells are first segmented using a Mask R-CNN-based network, resulting in a separate image for each cell. Part of the background information is preserved by Gaussian blurring of surrounding cells, while the target cells are highlighted. The classification model based on Swin Transformer not only reduces the computation but also achieves better results than the classical CNN model, ResNet50. The final results show that the accuracy of the method proposed in this paper reaches 96.16%. Therefore, this method is helpful for the detection and classification of lung cancer cells.","PeriodicalId":66197,"journal":{"name":"癌症治疗(英文)","volume":"123 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70994743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Liping Zhang, Qiaoling Zhong, Liling Han, Lijuan Zhang, QingHua Luo, Xinhua Xie, Zeyu Shuang, Na Li
{"title":"Comprehensive Online Management Based on Cloud Platform for Breast Cancer Patients Using Dual-Targeted Therapy with Macromolecular Monoclonal Antibodies","authors":"Liping Zhang, Qiaoling Zhong, Liling Han, Lijuan Zhang, QingHua Luo, Xinhua Xie, Zeyu Shuang, Na Li","doi":"10.4236/jct.2022.139053","DOIUrl":"https://doi.org/10.4236/jct.2022.139053","url":null,"abstract":"","PeriodicalId":66197,"journal":{"name":"癌症治疗(英文)","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70995577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-15DOI: 10.4236/jct.2021.1210045
T. Shouman, A. N. Taher, A. Helal, Ahmed Charaf
Objective: Concurrent chemoradiation value of the resected salivary tumor adjuvant context against regular radiation therapy alone. Design: Prospective randomized clinical trial. Patients: 48 patients were randomized to either adjuvant postoperative radiology alone versus concurrent chemoradiotherapy (weekly cisplatin 40 mg/m2 for 6 cycles) “with resected high-risk salivary tumors of the large and minor salivary gland”. Main Outcome Measures: Recurrent locoregional Free survival, distant free survival, and overall survival. Results: Out of the 48 participants in the study 31 patients had parotid gland tumors. 23 patients received solely adjuvant radiation while 25 patients received concurrent chemoradiotherapy. In the chemoradiation group, platinum-based regimens were employed in all. The mean age in both groups was 48 years. Adenoid cystic carcinoma was the primary pathogenic form of both arms 56% (28 cases). Stage II patients were 35% and 32%, stage III was 39% and 48% and stage VIa were 26% and 20% in the radiation arm and chemoradiotherapy arm respectively. 40 of 48 patients (83%) had close or positive surgical margins and 30 of 48 patients (62%) have a perineural invasion. Both risk variables are more or less well balanced in both arms with no statistical difference. The 2- and 4-year estimates of the locoregional recurrence-free survival rate in the chemoradiation group were 95% and 73%, compared to 77.4% and 43.6% in the radiation arm respectively (p = 007). In the two-and four-year-old chemoradiation arm distant free metastases were 100% and 59% compared to 68% and 39% respectively in the radiation arm (p = 0.08). The overall survival estimates for 2 and 4 years were 93% and 78% respectively in the Chemoradiation Group but in the radiation-alone group were 95% and 48% respectively. The statistically significant differences were p = 0.009 by log-rank testing. Treatment was generally tolerated, although, in the chemoradiation group adverse symptoms, mainly mucositis increased. Conclusions: Adding weekly cisplatin as a radiosensitizer for locally advanced stage or high-grade salivary gland cancer with adjuvant conventional radiation looks to be helpful and justifies further exploration in selected patients.
{"title":"Salivary Gland Tumors: Randomized Study of Adjuvant Chemo-Radiotherapy versus Radiotherapy Alone","authors":"T. Shouman, A. N. Taher, A. Helal, Ahmed Charaf","doi":"10.4236/jct.2021.1210045","DOIUrl":"https://doi.org/10.4236/jct.2021.1210045","url":null,"abstract":"Objective: Concurrent chemoradiation value of the resected salivary tumor adjuvant \u0000context against regular radiation therapy alone. Design: Prospective \u0000randomized clinical trial. Patients: 48 patients were randomized to \u0000either adjuvant postoperative radiology alone versus concurrent \u0000chemoradiotherapy (weekly cisplatin 40 mg/m2 for 6 cycles) “with \u0000resected high-risk salivary tumors of the large and minor salivary gland”. Main Outcome Measures: Recurrent locoregional Free survival, distant \u0000free survival, and overall survival. Results: Out of the 48 participants \u0000in the study 31 patients had parotid gland tumors. 23 patients received solely \u0000adjuvant radiation while 25 patients received concurrent chemoradiotherapy. In \u0000the chemoradiation group, platinum-based regimens were employed in all. The mean \u0000age in both groups was 48 years. Adenoid cystic carcinoma was the primary \u0000pathogenic form of both arms 56% (28 cases). Stage II patients were 35% and \u000032%, stage III was 39% and 48% and stage VIa were 26% and 20% in the radiation \u0000arm and chemoradiotherapy arm respectively. 40 of 48 patients (83%) had close \u0000or positive surgical margins and 30 of 48 patients (62%) have a perineural \u0000invasion. Both risk variables are more or less well balanced in both arms with \u0000no statistical difference. The 2- and 4-year estimates of the locoregional \u0000recurrence-free survival rate in the chemoradiation group were 95% and 73%, \u0000compared to 77.4% and 43.6% in the radiation arm respectively (p = 007). In the \u0000two-and four-year-old chemoradiation arm distant free metastases were 100% and \u000059% compared to 68% and 39% respectively in the radiation arm (p = 0.08). The \u0000overall survival estimates for 2 and 4 years were 93% and 78% respectively in \u0000the Chemoradiation Group but in the radiation-alone group were 95% and 48% \u0000respectively. The statistically significant differences were p = 0.009 by \u0000log-rank testing. Treatment was generally tolerated, although, in the \u0000chemoradiation group adverse symptoms, mainly mucositis increased. Conclusions: Adding weekly cisplatin as a radiosensitizer for locally advanced stage or \u0000high-grade salivary gland cancer with adjuvant conventional radiation looks to \u0000be helpful and justifies further exploration in selected patients.","PeriodicalId":66197,"journal":{"name":"癌症治疗(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42010666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mayson A. Alameen, A. Ibrahim, Touqeer Ahmed Siddiqui, Mervat Mohrous, Fadhel Alotaibi, Abdel Aziz Al Hamad, Hussein Farghaly
Primary isolated esophageal Hodgkin’s lymphoma is seldom in localization and when seen, it is usually the non-Hodgkin’s type. We reported a 68-year-old, diabetic and ex-smoker, presented to our hospital complaining of progressive difficulty of swallowing for nine months for both solid and liquid. He was on proton pump inhibitors. Recently, he had fever and drenching night sweat and significant loss of weight. He was diagnosed as a case of isolated esophageal Hodgkin’s lymphoma that was diagnosed based on endoscopic and radiological findings. Clinical manifestations, radiological imagines and histopathological features were described. Clinical management, fellow-up and outcome were precisely discussed.
{"title":"Primary Isolated Extra Nodal Esophageal Hodgkin Lymphoma in Diabetic Patient","authors":"Mayson A. Alameen, A. Ibrahim, Touqeer Ahmed Siddiqui, Mervat Mohrous, Fadhel Alotaibi, Abdel Aziz Al Hamad, Hussein Farghaly","doi":"10.4236/jct.2021.129043","DOIUrl":"https://doi.org/10.4236/jct.2021.129043","url":null,"abstract":"Primary \u0000isolated esophageal Hodgkin’s lymphoma is seldom in localization and when seen, it is usually the non-Hodgkin’s \u0000type. We reported a 68-year-old, diabetic and ex-smoker, presented to \u0000our hospital complaining of progressive difficulty of swallowing for nine months for both solid and liquid. \u0000He was on proton pump inhibitors. Recently, he had fever and drenching night sweat and significant loss of weight. He was diagnosed as a case of isolated esophageal \u0000Hodgkin’s lymphoma that was diagnosed based on endoscopic and radiological findings. Clinical \u0000manifestations, radiological imagines and histopathological features were \u0000described. Clinical management, fellow-up and outcome were precisely discussed.","PeriodicalId":66197,"journal":{"name":"癌症治疗(英文)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43079985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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